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ANKRD20A3 Gene

protein-coding   GIFtS: 38
GCID: GC09M043085

Ankyrin Repeat Domain 20 Family, Member A3

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ankyrin Repeat Domain 20 Family, Member A31 2
Ankyrin Repeat Domain 20A-Related2
Ankyrin Repeat Domain-Containing Protein 20A32

External Ids:    HGNC: 319811   Entrez Gene: 4414252   Ensembl: ENSG000001324987   UniProtKB: Q5VUR73   

Export aliases for ANKRD20A3 gene to outside databases

Previous GC identifers: GC09M045122 GC09M043079


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ANKRD20A3 Gene:
ANKRD20A3 (ankyrin repeat domain 20 family, member A3) is a protein-coding gene. An important paralog of this gene is POTEF.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000009.11  NT_078055.5  NC_018920.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ANKRD20A3 gene promoter:
         TBP   FOXO3   YY1   FOXO3b   Evi-1   POU2F1   POU2F1a   FOXO3a   POU2F1c   TGIF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidANKRD20A3 promoter sequence
   Search Chromatin IP Primers for ANKRD20A3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ANKRD20A3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p12   Ensembl cytogenetic band:  9p12   HGNC cytogenetic band: 9q12

ANKRD20A3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ANKRD20A3 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M043085:  view genomic region     (about GC identifiers)

Start:
43,064,966 bp from pter      End:
43,133,544 bp from pter
Size:
68,579 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: A20A3_HUMAN, Q5VUR7 (See protein sequence)
Recommended Name: Ankyrin repeat domain-containing protein 20A3  
Size: 823 amino acids; 94108 Da

Explore the universe of human proteins at neXtProt for ANKRD20A3: NX_Q5VUR7

Explore proteomics data for ANKRD20A3 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ANKRD20A3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001012419.1  
    ENSEMBL proteins: 
     ENSP00000464984   ENSP00000254835  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ANKRD: Ankyrin repeat domain containing

    2 InterPro protein domains:
     IPR002110 Ankyrin_rpt
     IPR020683 Ankyrin_rpt-contain_dom

    Graphical View of Domain Structure for InterPro Entry Q5VUR7

    ProtoNet protein and cluster: Q5VUR7

    UniProtKB/Swiss-Prot: A20A3_HUMAN, Q5VUR7
    Similarity: Contains 5 ANK repeats


    Find genes that share domains with ANKRD20A3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    Find genes that share ontologies with ANKRD20A3           About GenesLikeMe


    Animal Models:
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    nucleus3
    cytosol2

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ANKRD20A3
    Interactions:

        Search GeneGlobe Interaction Network for ANKRD20A3

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ANKRD20A3 (A20A3)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ANKRD20A3 gene: 
    NM_001012419.2  

    Unigene Cluster for ANKRD20A3:

    Ankyrin repeat domain 20 family, member A3
    Hs.632663  [show with all ESTs]
    Unigene Representative Sequence: NM_001012419
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000417703 ENST00000344538 ENST00000254835(uc004acw.1 uc010mna.1)
    ENST00000473324 ENST00000485255
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    Additional mRNA sequence: 

    BC140809.1 BC171793.1 

    2 DOTS entries:

    DT.121156750  DT.95241138 

    14 AceView cDNA sequences:

    AW182400 M79082 NM_032250 BP349185 BM984472 BU569565 AA363705 AL136793 
    BU852794 BX478214 BI035374 BE072622 BG209427 BF360942 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ANKRD20A3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ANKRD20A3 Expression
    About this image

    ANKRD20A3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ANKRD20A3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.632663
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ANKRD20A3 gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves --
    Uncharacterized protein
    18(a)
    1 → many
    1(24064036-24111623)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    41(a)
    many ↔ many
    GL344195.1(38786-58936)
    zebrafish
    (Danio rerio)
    Actinopterygii ANKRD76
    ankyrin repeat domain 7
    9(a)
    1 → many
    25(3581527-3655709) ENSDARG00000013015
            Species with no ortholog for ANKRD20A3

    ENSEMBL Gene Tree for ANKRD20A3 (if available)
    TreeFam Gene Tree for ANKRD20A3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ANKRD20A3 gene
    ANKRD20A21 2  ANKRD20A11 2  ANKRD20A41 2  POTEF2  POTEI2  ANKRD30A2  POTEB22  ANKRD362  
    ANKRD72  POTEB2  ANKRD30BL2  POTEH2  ANKRD30B2  LOC6442492  ENSG000002663022  ANKRD36C2  
    POTEJ2  POTEC2  ANKRD262  POTEG2  ANKRD622  ANKRD18A2  POTEM2  CCDC144A2  
    POTED2  POTEE2  ANKRD18B2  LOC1002889662  
    11 SIMAP similar genes for ANKRD20A3 using alignment to 2 protein entries:     A20A3_HUMAN (see all proteins):
    ANKRD20A1    ANKRD20A2    ANKRD20A4    ANKRD20A8P    ANKRD19P    MGC26718
    ANKRD18A    ANKRD36BP1    ANKRD36    ANKRD62    ANKRD18B

    Find genes that share paralogs with ANKRD20A3           About GenesLikeMe


    5 Pseudogenes.org Pseudogenes for ANKRD20A3
    PGOHUM00000248331 PGOHUM00000239111 PGOHUM00000239143 PGOHUM00000235855 PGOHUM00000233940


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ANKRD20A3 (see all 139)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1999271281,2
    --43090070(+) CTCTT-/ACTTACA 1 -- ut310--------
    rs1863663861,2
    --43093133(+) TTTGCG/TATTGC 1 -- int10--------
    rs625523111,2
    C--43101400(+) AAGTAG/AAATAA 1 -- int11Minor allele frequency- A:0.50NA 2
    rs1831837551,2
    --43101414(+) ACATAA/CACTGT 1 -- int10--------
    rs117929511,2
    H--43101447(-) AGAAAA/CAGTGT 1 -- int10--------
    rs3714457271,2
    C--43101512(+) GTTGC-/TGT/  
      TGTTGT
    TGTTG
    3 -- int1 cds10--------
    rs2011841371,2
    C--43101543(+) TGTTG-/TGGTTGA 1 -- int10--------
    rs287187561,2
    C--43101607(+) TCACCA/GCAACT 1 -- int10--------
    rs49294111,2
    C,A,H--43101775(+) tgcccG/Acctca 1 -- int11Minor allele frequency- A:0.00NA 2
    rs49295061,2
    C,A,H--43101793(+) aaagtG/Actggg 1 -- int12Minor allele frequency- A:0.00NA 4

    HapMap Linkage Disequilibrium report for ANKRD20A3 (43064966 - 43133544 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for ANKRD20A3 (see all 20):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2738445CNV Deletion23290073
    esv2738489CNV Deletion23290073
    esv1000243CNV Deletion20482838
    esv2677102CNV Deletion23128226
    nsv8485CNV Loss18304495
    dgv8236n71CNV Loss21882294
    nsv893391CNV Loss21882294
    nsv893390CNV Loss21882294
    nsv893356CNV Gain21882294
    nsv893386CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ANKRD20A3 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with ANKRD20A3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (Nature 2004)
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 441425 HGNC: 31981 AceView: LOC441424 Ensembl:ENSG00000132498 euGenes: HUgn441425
    ECgene: ANKRD20A3 H-InvDB: ANKRD20A3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ANKRD20A3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ANKRD20A3 gene:
    Search GeneIP for patents involving ANKRD20A3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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