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ANKRD20A2 Gene

protein-coding   GIFtS: 31
GCID: GC09P042358

Ankyrin Repeat Domain 20 Family, Member A2

  Search for ANKRD20A2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ankyrin Repeat Domain 20 Family, Member A21 2
Ankyrin Repeat Domain-Containing Protein 20A22

External Ids:    HGNC: 319791   Entrez Gene: 4414302   Ensembl: ENSG000001831487   UniProtKB: Q5SQ803   

Export aliases for ANKRD20A2 gene to outside databases

Previous GC identifer: GC09P045519


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ANKRD20A2 Gene:
ANKRD20A2 (ankyrin repeat domain 20 family, member A2) is a protein-coding gene. An important paralog of this gene is POTEF.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the ANKRD20A2 gene promoter:
         TBP   FOXO3   YY1   FOXO3b   Evi-1   POU2F1   POU2F1a   FOXO3a   POU2F1c   TGIF   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ANKRD20A2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p12   Ensembl cytogenetic band:  9p12   HGNC cytogenetic band: 9p12

ANKRD20A2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ANKRD20A2 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P042358:  view genomic region     (about GC identifiers)

Start:
42,368,303 bp from pter      End:
42,411,410 bp from pter
Size:
43,108 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: A20A2_HUMAN, Q5SQ80 (See protein sequence)
Recommended Name: Ankyrin repeat domain-containing protein 20A2  
Size: 823 amino acids; 94087 Da

Explore the universe of human proteins at neXtProt for ANKRD20A2: NX_Q5SQ80

Explore proteomics data for ANKRD20A2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ANKRD20A2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001012421.1  
    ENSEMBL proteins: 
     ENSP00000366826  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ANKRD: Ankyrin repeat domain containing

    2 InterPro protein domains:
     IPR002110 Ankyrin_rpt
     IPR020683 Ankyrin_rpt-contain_dom

    Graphical View of Domain Structure for InterPro Entry Q5SQ80

    ProtoNet protein and cluster: Q5SQ80

    UniProtKB/Swiss-Prot: A20A2_HUMAN, Q5SQ80
    Similarity: Contains 5 ANK repeats


    ANKRD20A2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    ANKRD20A2 for ontologies           About GeneDecksing


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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ANKRD20A2
    Interactions:

        Search GeneGlobe Interaction Network for ANKRD20A2

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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      Browse compounds at ApexBio 

    Browse Tocris compounds for ANKRD20A2 (A20A2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ANKRD20A2 gene: 
    NM_001012421.1  

    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000377601(uc004acd.3 uc010mmv.3) ENST00000477139
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    Selected AceView cDNA sequences (see all 69):

    CR605783 AW026376 AA349996 AL043509 AL833349 AW182400 AA864338 BF941442 
    CB853646 CD251944 BI711552 CD299935 CK820439 M79082 AL534157 AL136793 
    BE794730 BC064148 AI126131 AI452545 BM984472 BU569565 AK125850 BI913628 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ANKRD20A2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ANKRD20A2 Expression
    About this image

    ANKRD20A2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ANKRD20A2 Protein Expression
        Custom PCR Arrays for ANKRD20A2
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ANKRD20A2 gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves --
    Uncharacterized protein
    18(a)
    1 → many
    1(24064036-24111623)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    41(a)
    many ↔ many
    GL344195.1(38786-58936)
    zebrafish
    (Danio rerio)
    Actinopterygii ANKRD76
    ankyrin repeat domain 7
    9(a)
    1 → many
    25(3581527-3655709) ENSDARG00000013015
            Species with no ortholog for ANKRD20A2

    ENSEMBL Gene Tree for ANKRD20A2 (if available)
    TreeFam Gene Tree for ANKRD20A2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ANKRD20A2 gene
    ANKRD20A31 2  ANKRD20A11 2  ANKRD20A41 2  POTEF2  POTEI2  ANKRD30A2  POTEB22  ANKRD362  
    ANKRD72  POTEB2  ANKRD30BL2  POTEH2  ANKRD30B2  LOC6442492  ENSG000002663022  ANKRD36C2  
    POTEJ2  POTEC2  ANKRD262  POTEG2  ANKRD622  ANKRD18A2  POTEM2  CCDC144A2  
    POTED2  POTEE2  ANKRD18B2  LOC1002889662  
    18 SIMAP similar genes for ANKRD20A2 using alignment to 2 protein entries:     A20A2_HUMAN (see all proteins):
    ANKRD20A1    ANKRD20A3    ANKRD20A4    ANKRD20A8P    ANKRD19P    ANKRD30BL
    MGC26718    DKFZp781D1722    ANKRD36BP1    PRED4    POTEG    ANKRD62
    ANKRD18B    POTEA    ANKRD18A    PSMD10    POTED    POTEB

    ANKRD20A2 for paralogs           About GeneDecksing


    Selected Pseudogenes.org Pseudogenes for ANKRD20A2 (see all 8)
    PGOHUM00000244178 PGOHUM00000244187 PGOHUM00000244891 PGOHUM00000244902 PGOHUM00000239106


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ANKRD20A2 (see all 182)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2009845881,2
    C--42366347(+) TATTAC/GAAAAT 1 -- us2k10--------
    rs1880202721,2
    C--42366663(+) AAATAG/AGTAGA 1 -- us2k11Minor allele frequency- A:0.00EU 385
    rs1126506941,2
    C--42366702(+) CCGTAC/TCTTGC 1 -- us2k10--------
    rs1121423991,2
    C,F--42366723(+) CAGGCC/GGAGGA 1 -- us2k11Minor allele frequency- G:0.08EU 201
    rs1832932661,2
    C--42366898(+) GGCTAC/TGCTAG 1 -- us2k10--------
    rs801303091,2
    C--42367925(+) GCACCG/CTATCT 1 -- us2k11Minor allele frequency- C:0.00NA 2
    rs745565851,2
    C,F--42368061(+) GCGCAT/CGCCCA 1 -- us2k12Minor allele frequency- C:0.25NA 4
    rs787415011,2
    C--42368099(+) GCCGCT/CAGGGA 1 -- us2k12Minor allele frequency- C:0.25NA 4
    rs745367591,2
    C--42368113(+) TCTTCC/TGGGAG 1 -- us2k12Minor allele frequency- T:0.25NA 4
    rs786650081,2
    C--42368172(+) TCACTC/TGGTCT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ANKRD20A2 (42368303 - 42411410 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for ANKRD20A2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2738445CNV Deletion23290073
    esv2677102CNV Deletion23128226
    nsv8485CNV Loss18304495
    nsv893173CNV Gain21882294
    dgv8190n71CNV Gain+Loss21882294
    nsv893172CNV Gain+Loss21882294
    dgv2362e1CNV Complex17122850

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ANKRD20A2 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with ANKRD20A2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (Nature 2004)
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 441430 HGNC: 31979 AceView: LOC441430 Ensembl:ENSG00000183148 euGenes: HUgn441430
    ECgene: ANKRD20A2 H-InvDB: ANKRD20A2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ANKRD20A2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ANKRD20A2 gene:
    Search GeneIP for patents involving ANKRD20A2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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