Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ANKRD2 Gene

protein-coding   GIFtS: 52
GCID: GC10P099322

ankyrin repeat domain 2 (stretch responsive muscle)
 Explore 16 diseases affiliated with
ANKRD2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ANKRD2    

Aliases
for ANKRD2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Ankyrin Repeat Domain 2 (Stretch Responsive Muscle)1 2
ARPP1 2 3 5
Skeletal Muscle Ankyrin Repeat Protein2 3
HArpp1
Ankyrin Repeat Domain-Containing Protein 22
Ankyrin-Repeat Protein2

External Ids:    HGNC: 4951   Entrez Gene: 262872   Ensembl: ENSG000001658877   OMIM: 6107345   UniProtKB: Q9GZV13   

Export aliases for ANKRD2 gene to outside databases

Previous GC identifers: GC10P098225 GC10P098565 GC10P099463 GC10P098996 GC10P092958


Summaries
for ANKRD2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for ANKRD2:
ANKRD2 belongs to the conserved muscle ankyrin repeat protein (MARP) family. Expression of MARPs is induced in response
to physiologic stress, injury, and hypertrophy (Miller et al., 2003 (PubMed 14583192)).(supplied by OMIM, Mar 2008)

UniProtKB/Swiss-Prot: ANKR2_HUMAN, Q9GZV1
Function: May play an important role in skeletal muscle hypertrophy

Gene Wiki entry for ANKRD2


Genomic Views
for ANKRD2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NC_018921.1  NT_030059.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ANKRD2 gene promoter:
         Max   MyoD   MIF-1   c-Myc   GATA-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ANKRD2 promoter sequence
   Search SABiosciences Chromatin IP Primers for ANKRD2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ANKRD2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q23   Ensembl cytogenetic band:  10q24.2   HGNC cytogenetic band: 10q23

ANKRD2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ANKRD2 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P099322:  view genomic region     (about GC identifiers)

Start:
 99,332,198 bp from pter      End:
 99,343,641 bp from pter
Size:
 11,444 bases      Orientation:
 plus strand

Proteins
for ANKRD2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ANKR2_HUMAN, Q9GZV1 (See protein sequence)
Recommended Name: Ankyrin repeat domain-containing protein 2  
Size: 360 amino acids; 39859 Da
Subunit: Interacts with TTN/titin
Sequence caution: Sequence=AAH20817.2; Type=Erroneous initiation; Sequence=AK056990; Type=Erroneous termination;
Positions=210; Note=Translated as Gln; Sequence=BAB60958.1; Type=Erroneous initiation; Sequence=CAC19411.1;
Type=Erroneous initiation; Sequence=CAC19412.1; Type=Erroneous initiation; Sequence=CAE47432.1; Type=Erroneous
initiation; Sequence=CAI14194.1; Type=Erroneous initiation; Sequence=CAI15463.1; Type=Erroneous initiation;
Secondary accessions: Q3B778 Q5T456 Q70EZ9 Q8WUD7 Q96MG0 Q9NQC9
Alternative splicing: 2 isoforms:  Q9GZV1-1   Q9GZV1-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ANKRD2: NX_Q9GZV1

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9GZV1

    • ANKRD2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001123453.1  NP_065082.2  

    ENSEMBL proteins: 
     ENSP00000359689   ENSP00000403114   ENSP00000306163   ENSP00000298808  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: ANKRD2
    OriGene Protein Over-expression Lysate (see all 2): ANKRD2
    OriGene Custom Protein Services for ANKRD2 
    GenScript Custom Purified and Recombinant Proteins Services for ANKRD2
    Novus Biologicals ANKRD2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for ANKRD2

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0030016myofibril ----
    GO:0030017sarcomere ----
    GO:0031674I band IEA--
    GO:0043231intracellular membrane-bounded organelle IDA--


    ANKRD2 for ontologies           About GeneDecksing



    ANKRD2 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for ANKRD2 
    GenScript Custom Superior Antibodies Services for ANKRD2
    Novus Biologicals ANKRD2 Antibodies
    Abcam antibodies for ANKRD2 
    Uscn Antibodies for ANKRD2
    Search ThermoFisher Antibodies for ANKRD2

    Assay Products for ANKRD2: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ANKRD2
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for ANKRD2

    Protein Domains /
    Families
    for ANKRD2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ANKRD2 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR020683 Ankyrin_rpt-contain_dom
     IPR002110 Ankyrin_rpt

    Graphical View of Domain Structure for InterPro Entry Q9GZV1

    ProtoNet protein and cluster: Q9GZV1

    1 Blocks protein family: IPB002110 Ankyrin repeat signature

    UniProtKB/Swiss-Prot: ANKR2_HUMAN, Q9GZV1
    Similarity: Contains 5 ANK repeats


    Function
    for ANKRD2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: ANKR2_HUMAN, Q9GZV1
    Function: May play an important role in skeletal muscle hypertrophy

    miRNA
    Products:            		 OriGene 3'-UTR Clone (see all 2): ANKRD2
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ANKRD2
    1 QIAGEN miScript miRNA Assays for microRNA that regulate ANKRD2:
    hsa-miR-548p
    SwitchGear 3'UTR luciferase reporter plasmid: ANKRD2 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ANKRD2 (see all 7)
    OriGene shRNA RFP: ANKRD2
    OriGene siRNA: ANKRD2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ANKRD2

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for ANKRD2

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ANKRD2 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ANKRD2 (see all 4)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: ANKRD2 (NM_014915)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ANKRD2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ANKRD2 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for ANKRD2
    Search LifeMap BioReagents cell lines for ANKRD2

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANKRD2

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008307structural constituent of muscle NAS11444853
    GO:0031432titin binding IEA--


    ANKRD2 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for ANKRD2:
     Cell division defect  Increased G2M DNA content 

    Animal Models:
         Mouse knock-out Ankrd2tm1Krc for ANKRD2
         1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Ankrd2):
     muscle 

    ANKRD2 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for ANKRD2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ANKRD2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    5/9 Interacting proteins for ANKRD2 (Q9GZV13 ENSP000003061634) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PMLP295903, ENSP000002680584I2D: score=2 STRING: ENSP00000268058
    TP53P046373, ENSP000002693054I2D: score=2 STRING: ENSP00000269305
    HBP1O603813, ENSP000002225744I2D: score=1 STRING: ENSP00000222574
    TCAPO152733, ENSP000003126244I2D: score=2 STRING: ENSP00000312624
    YBX1P678093, ENSP000003616264I2D: score=2 STRING: ENSP00000361626
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006936muscle contraction NAS10873377
    GO:0007517muscle organ development NAS11444853


    ANKRD2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for ANKRD2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ANKRD2
    Search CenterWatch for drugs/clinical trials and news about ANKRD2 / ANKR2 

    Transcripts
    for ANKRD2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ANKRD2 gene (2 alternative transcripts): 
    NM_001129981.1  NM_020349.2  

    Unigene Cluster for ANKRD2:

    Ankyrin repeat domain 2 (stretch responsive muscle)
    Hs.73708  [show with all ESTs]
    Unigene Representative Sequence: AJ583444
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000370655(uc001knw.3 uc009xvu.3) ENST00000455090 ENST00000307518
    ENST00000298808

    miRNA
    Products:             		 OriGene 3'-UTR Clone (see all 2): ANKRD2
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ANKRD2
    1 QIAGEN miScript miRNA Assays for microRNA that regulate ANKRD2:
    hsa-miR-548p
    SwitchGear 3'UTR luciferase reporter plasmid: ANKRD2 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ANKRD2 (see all 7)
    OriGene shRNA RFP: ANKRD2
    OriGene siRNA: ANKRD2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ANKRD2
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ANKRD2 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ANKRD2 (see all 4)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: ANKRD2 (NM_014915)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ANKRD2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ANKRD2 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ANKRD2
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ANKRD2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ANKRD2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ANKRD2

    Additional cDNA sequence: 

    AB058599.1 AJ249975.1 AJ304805.1 AJ583444.1 AK056990.1 AK314763.1 BC020817.1 BC107759.1 

    2 DOTS entries:

    DT.408816  DT.95212230 

    24/86 AceView cDNA sequences (see all 86):

    AJ345979 AJ346216 NM_020349 F26754 AI684954 AJ346055 AJ345972 AJ571966 
    AB058599 F24152 AJ346249 AJ346507 AJ346764 AA179959 AJ346480 F34910 
    F32675 BC020817 AJ346337 BE926721 AA180314 AI936300 AA311094 BF790486 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for ANKRD2    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b
    SP1:                                                                  
    SP2:                                            -                     


    ECgene alternative splicing isoforms for ANKRD2

    Expression
    for ANKRD2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ANKRD2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ATCCAGGAGC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    ANKRD2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    10/15 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 15) 
    Tissue Anatomical Compartment CellCategory (developmental path)
    LimbForelimb Dorsal MusclesMultinuclear MyocytesSkeletal Muscle
    LimbForelimb Ventral MusclesMultinuclear MyocytesSkeletal Muscle
    LimbHindlimb Dorsal MuscleMultinuclear MyocytesSkeletal Muscle
    LimbHindlimb Ventral MuscleMultinuclear MyocytesSkeletal Muscle
    Skeletal MuscleAnterior Neck MusclesMultinuclear MyocytesSkeletal Muscle
    Skeletal MuscleCervical Back MusclesMultinuclear MyocytesSkeletal Muscle
    Skeletal MuscleLumbar Back MusclesMultinuclear MyocytesSkeletal Muscle
    Skeletal MuscleLumbar Vertebrae Column MusclesMultinuclear MyocytesSkeletal Muscle
    Skeletal MusclePelvic MusclesMultinuclear MyocytesSkeletal Muscle
    Skeletal MusclePosterior Neck MusclesMultinuclear MyocytesSkeletal Muscle
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See ANKRD2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ANKRD2

    SOURCE GeneReport for Unigene cluster: Hs.73708

    UniProtKB/Swiss-Prot: ANKR2_HUMAN, Q9GZV1
    Tissue specificity: Expressed in skeletal and cardiac muscles. Found in slow fibers. Also expressed in kidney, but to a
    lower extent

        SABiosciences Custom PCR Arrays for ANKRD2
    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ANKRD2
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ANKRD2
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ANKRD2
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ANKRD2
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANKRD2

    Orthologs
    for ANKRD2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for ANKRD2 gene from 5/18 species (see all 18)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Ankrd21 , 5 ankyrin repeat domain 2 (stretch responsive muscle)1, 5 85.47(n)1
    89.33(a)1    		   19 (35.65 cM)5
    566421  NM_020033.11  NP_064417.11 
     420360385 
    chicken
    (Gallus gallus)    		 Aves ANKRD21 ankyrin repeat domain 2 (stretch responsive muscle) 71.72(n)
    68.35(a)    		   423841  XM_421709.3  XP_421709.3 
    lizard
    (Anolis carolinensis)    		 Reptilia ANKRD26
    		 --
    		 63(a)
    		 1 ↔ 1
    		 3(39245142-39255166)
    African clawed frog
    (Xenopus laevis)    		 Amphibia ankrd2-prov2 ankyrin repeat domain 2 (stretch responsive muscle) 74.82(n)    BC044065.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii ankrd26
    		 ankyrin repeat domain 2 (stretch responsive muscle...
    		 51(a)
    		 1 ↔ 1
    		 13(41341677-41353079)


    ENSEMBL Gene Tree for ANKRD2 (if available)
    TreeFam Gene Tree for ANKRD2 (if available) 

    Paralogs
    for ANKRD2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ANKRD2 gene
    PSMD102  ANKRD232  ANKRD12  
    9 SIMAP similar genes for ANKRD2 using alignment to 2 protein entries:     ANKR2_HUMAN (see all proteins):
    ANKRD1    CDKN2C    ANKRD23    ANKDD1A    IkBa    CDKN2D
    DKFZp761E1322    MTPN    PSMD10

    ANKRD2 for paralogs           About GeneDecksing



    Genomic Variants
    for ANKRD2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/274 NCBI SNPs in ANKRD2 are shown (see all 274)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 10 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1137209981,2
    		C,--92956446(+) TGAGCC/TGTGAA 1 -- ut312Minor allele frequency- T:0.06CSA WA 120
    rs412961251,2
    		--92956607(+) CAACCA/GGGAGG 1 -- ut310--------
    rs1137657371,2
    		C--92968511(+) CCTGGA/C/TAAGCT 2 -- us2k11CSA 1
    rs616351541,2
    		C,--92968724(+) AGAGAC/TAGCAG 2 -- us2k11Minor allele frequency- T:0.50WA 2
    rs786980591,2
    		C,F,--92968931(+) GGAAGG/AGGAAG 2 -- us2k12Minor allele frequency- A:0.04WA EA 238
    rs122433251,2
    		C,F,H,--92968954(+) CACCTT/CGGACT 2 -- us2k113Minor allele frequency- C:0.06NA NS EA WA CSA 688
    rs413144711,2
    		--92969993(+) GTCACA/C/GTGGCT 2 -- us2k10--------
    rs1471193771,2
    		C,F,--99330289(+) GCCCAC/TGGACC 2 -- us2k11Minor allele frequency- T:0.00EU 1317
    rs1148880221,2
    		--99330495(+) TGTCAG/AAGAAA 2 -- us2k11Minor allele frequency- A:0.01WA 118
    rs1385114211,2
    		--99330504(+) AAAGGC/TGAACA 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for ANKRD2 (99332198 - 99343641 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for ANKRD2
         1 CNV: 10339

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ANKRD2
    DNA2.0 Custom Variant and Variant Library Synthesis for ANKRD2

    Disorders / Diseases
    for ANKRD2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ANKRD2 for disorders           About GeneDecksing

    OMIM gene information: 610734    OMIM disorders: --

    16 diseases for ANKRD2:    About MalaCards
    dubin-johnson syndrome    amyotrophic lateral sclerosis    lateral sclerosis    muscle hypertrophy
    epithelioid sarcoma    renal oncocytoma    dilated cardiomyopathy    renal cell carcinoma
    paralysis    cardiomyopathy    rhabdomyosarcoma    sarcoma
    alzheimer's disease    blindness    hypoxia    carcinoma

    2 Novoseek disease relationships for ANKRD2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hypertrophy 26 3 15136035 (2)
    tumors 0 9 16021567 (3), 15136035 (1)

    Human Genome Epidemiology (HuGE) Navigator: ANKRD2 (1 document)

    Export disorders for ANKRD2 gene to outside databases

    Publications
    for ANKRD2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ANKRD2 gene, integrated from 9 sources (see all 31):
    (articles sorted by number of sources associating them with ANKRD2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of Ankrd2, a novel skeletal muscle gene coding for a stretch-responsive ankyrin-repeat protein. (PubMed id 10873377)1, 2, 3, 9 Kemp T.J.... Coulton G.R. (2000)
    2. The Ankrd2 protein, a link between the sarcomere and the nucleus in skeletal muscle. (PubMed id 15136035)1, 3, 9 Kojic S....Faulkner G. (2004)
    3. Expression of Ankrd2 in fast and slow muscles and its response to stretch are consistent with a role in slow muscle function. (PubMed id 15677738)1, 3 Mckoy G....Coulton G.R. (2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (2004)
    7. The muscle ankyrin repeat proteins: CARP, ankrd2/Arpp and DARP as a family of titin filament-based stress response molecules. (PubMed id 14583192)1, 2 Miller M.K.... Labeit S. (2003)
    8. Identification of a novel human ankyrin-repeated protein homologous to CARP. (PubMed id 11453652)1, 2 Moriyama M.... Ito H. (2001)
    9. Characterization of human skeletal muscle Ankrd2. (PubMed id 11444853)1, 2 Pallavicini A.... Valle G. (2001)
    10. Immunohistochemical analysis of a muscle ankyrin-repeat protein, Arpp, in paraffin-embedded tumors: evaluation of Arpp as a tumor marker for rhabdomyosarcoma. (PubMed id 16021567)1, 9 Ishiguro N....Yoshida H. (2005)

    External Searches for ANKRD2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing ANKRD2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 26287 HGNC: 495 AceView: ANKRD2 Ensembl:ENSG00000165887 euGenes: HUgn26287
    ECgene: ANKRD2 H-InvDB: ANKRD2

    Other Databases showing ANKRD2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ANKRD2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ANKRD2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for ANKRD2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ANKRD2 gene:
    Search GeneIP for patents involving ANKRD2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for ANKRD2 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for ANKRD2  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ANKRD2   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ANKRD2  
     OriGene Protein Over-expression Lysate for ANKRD2   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for ANKRD2   OriGene 3'-UTR Clone for ANKRD2  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ANKRD2   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ANKRD2  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for ANKRD2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ANKRD2   OriGene Custom Protein Services for ANKRD2  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ANKRD2
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ANKRD2
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ANKRD2
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ANKRD2
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ANKRD2
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ANKRD2
     GenScript Custom Purified and Recombinant Proteins Services for ANKRD2 GenScript cDNA clones with any tag delivered in your preferred vector for ANKRD2
     GenScript Custom Assay Services for ANKRD2 GenScript Custom Superior Antibodies Services for ANKRD2
     GenScript Custom overexpressing Cell Line Services for ANKRD2 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in ANKRD2 promoter
     Search Chromatin IP Primers for ANKRD2
     RT2 qPCR Primer Assay in human, mouse, rat ANKRD2
     GNC Network for ANKRD2
     SABiosciences Custom PCR Arrays for ANKRD2
     Search Tocris compounds for ANKRD2
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     ANKRD2 antibodies
     ANKRD2 lysates
     Antibodies for ANKRD2
     See all of Abcam's Antibodies, Kits and Proteins for ANKRD2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     ANKRD2 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for ANKRD2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANKRD2
     SwitchGear 3'UTR luciferase reporter plasmids for ANKRD2
     SwitchGear Promoter luciferase reporter plasmids for ANKRD2
     Search ThermoFisher Antibodies for ANKRD2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ANKRD2
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      ANKRD2 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4