Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ANKRD2 Gene

Aliases for ANKRD2 Gene

  • Ankyrin Repeat Domain 2 (Stretch Responsive Muscle) 2 3
  • ARPP 3 4 6
  • Skeletal Muscle Ankyrin Repeat Protein 3 4
  • Ankyrin Repeat Domain-Containing Protein 2 3
  • HArpp 4

External Ids for ANKRD2 Gene

Previous GeneCards Identifiers for ANKRD2 Gene

  • GC10P098225
  • GC10P098565
  • GC10P099463
  • GC10P098996
  • GC10P099322
  • GC10P092958

Summaries for ANKRD2 Gene

Entrez Gene Summary for ANKRD2 Gene

  • This gene encodes a protein that belongs to the muscle ankyrin repeat protein (MARP) family. A similar gene in rodents is a component of a muscle stress response pathway and plays a role in the stretch-response associated with slow muscle function. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2014]

GeneCards Summary for ANKRD2 Gene

ANKRD2 (Ankyrin Repeat Domain 2 (Stretch Responsive Muscle)) is a Protein Coding gene. Diseases associated with ANKRD2 include dubin-johnson syndrome. GO annotations related to this gene include structural constituent of muscle and titin binding. An important paralog of this gene is ANKRD1.

UniProtKB/Swiss-Prot for ANKRD2 Gene

  • Functions as a negative regulator of myocyte differentiation. May interact with both sarcoplasmic structural proteins and nuclear proteins to regulate gene expression during muscle development and in response to muscle stress.

Gene Wiki entry for ANKRD2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANKRD2 Gene

Genomics for ANKRD2 Gene

Regulatory Elements for ANKRD2 Gene

Genomic Location for ANKRD2 Gene

Start:
97,572,499 bp from pter
End:
97,583,884 bp from pter
Size:
11,386 bases
Orientation:
Plus strand

Genomic View for ANKRD2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ANKRD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANKRD2 Gene

Proteins for ANKRD2 Gene

  • Protein details for ANKRD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9GZV1-ANKR2_HUMAN
    Recommended name:
    Ankyrin repeat domain-containing protein 2
    Protein Accession:
    Q9GZV1
    Secondary Accessions:
    • Q3B778
    • Q5T456
    • Q70EZ9
    • Q8WUD7
    • Q96MG0
    • Q9NQC9

    Protein attributes for ANKRD2 Gene

    Size:
    360 amino acids
    Molecular mass:
    39859 Da
    Quaternary structure:
    • Interacts with ID3; both proteins cooperate in myoblast differentiation (By similarity). Interacts with TTN/titin. Interacts (via ANK repeats) with TCAP; the interaction is direct. Interacts with TJP1 (via PDZ domains). Interacts with PML; the interaction is direct. Interacts with p53/TP53. Interacts with YBX1. Interacts with AKT2.
    SequenceCaution:
    • Sequence=AK056990; Type=Erroneous termination; Positions=210; Note=Translated as Gln.; Evidence={ECO:0000305}; Sequence=BAB60958.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAC19411.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAC19412.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAE47432.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for ANKRD2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ANKRD2 Gene

Proteomics data for ANKRD2 Gene at MOPED

Post-translational modifications for ANKRD2 Gene

  • Phosphorylation at Ser-99 by PKB/AKT2 in response to oxidative stress induces translocation to the nucleus and negatively regulates myoblast differentiation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ANKRD2 Gene

No data available for DME Specific Peptides for ANKRD2 Gene

Domains for ANKRD2 Gene

Gene Families for ANKRD2 Gene

HGNC:
  • ANKRD :Ankyrin repeat domain containing

Protein Domains for ANKRD2 Gene

Suggested Antigen Peptide Sequences for ANKRD2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9GZV1

UniProtKB/Swiss-Prot:

ANKR2_HUMAN :
  • Q9GZV1
Similarity:
  • Contains 5 ANK repeats.
genes like me logo Genes that share domains with ANKRD2: view

Function for ANKRD2 Gene

Molecular function for ANKRD2 Gene

UniProtKB/Swiss-Prot Function: Functions as a negative regulator of myocyte differentiation. May interact with both sarcoplasmic structural proteins and nuclear proteins to regulate gene expression during muscle development and in response to muscle stress.

Gene Ontology (GO) - Molecular Function for ANKRD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0008307 structural constituent of muscle NAS 11444853
GO:0031432 titin binding IBA --
GO:0043422 protein kinase B binding IPI 21737686
GO:0061629 RNA polymerase II sequence-specific DNA binding transcription factor binding IDA 24434510
genes like me logo Genes that share ontologies with ANKRD2: view

Phenotypes for ANKRD2 Gene

MGI mutant phenotypes for ANKRD2:
inferred from 1 alleles
GenomeRNAi human phenotypes for ANKRD2:
genes like me logo Genes that share phenotypes with ANKRD2: view

Animal Models for ANKRD2 Gene

MGI Knock Outs for ANKRD2:

Animal Model Products

CRISPR Products

miRNA for ANKRD2 Gene

miRTarBase miRNAs that target ANKRD2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ANKRD2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for ANKRD2 Gene

Localization for ANKRD2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ANKRD2 Gene

Cytoplasm, myofibril, sarcomere, I band. Cytoplasm, cytosol. Nucleus. Nucleus, PML body. Note=In the sarcoplasm of differentiated striated muscle cells, where it is cytosolic and enriched in the I band. In nucleus and PML bodies of proliferating and undifferentiated myoblasts. Associates with the euchromatin in the nucleus of myocytes upon muscle stress.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ANKRD2 Gene COMPARTMENTS Subcellular localization image for ANKRD2 gene
Compartment Confidence
cytosol 3
nucleus 2
cytoskeleton 1
extracellular 1

Gene Ontology (GO) - Cellular Components for ANKRD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000791 euchromatin ISS --
GO:0005634 nucleus IDA 21737686
GO:0005829 cytosol IDA 21737686
GO:0016605 PML body IEA --
GO:0030016 myofibril --
genes like me logo Genes that share ontologies with ANKRD2: view

Pathways for ANKRD2 Gene

SuperPathways for ANKRD2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ANKRD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IGI 24434510
GO:0006936 muscle contraction NAS 10873377
GO:0007517 muscle organ development NAS 11444853
GO:0035914 skeletal muscle cell differentiation IEA --
GO:0043619 regulation of transcription from RNA polymerase II promoter in response to oxidative stress IDA 24434510
genes like me logo Genes that share ontologies with ANKRD2: view

No data available for Pathways by source for ANKRD2 Gene

Transcripts for ANKRD2 Gene

Unigene Clusters for ANKRD2 Gene

Ankyrin repeat domain 2 (stretch responsive muscle):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ANKRD2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ANKRD2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b
SP1:
SP2: -

Relevant External Links for ANKRD2 Gene

GeneLoc Exon Structure for
ANKRD2
ECgene alternative splicing isoforms for
ANKRD2

Expression for ANKRD2 Gene

mRNA expression in normal human tissues for ANKRD2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ANKRD2 Gene

This gene is overexpressed in Muscle - Skeletal (30.8) and Heart - Left Ventricle (18.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ANKRD2 Gene

SOURCE GeneReport for Unigene cluster for ANKRD2 Gene Hs.73708

mRNA Expression by UniProt/SwissProt for ANKRD2 Gene

Q9GZV1-ANKR2_HUMAN
Tissue specificity: Mostly expressed in skeletal and cardiac muscles. Found in slow fibers. Also expressed in kidney, but to a lower extent (at protein level).
genes like me logo Genes that share expressions with ANKRD2: view

In Situ Assay Products

Orthologs for ANKRD2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ANKRD2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ANKRD2 35
  • 99.35 (n)
  • 99.17 (a)
ANKRD2 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ANKRD2 35
  • 86.87 (n)
  • 89.64 (a)
ANKRD2 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ANKRD2 35
  • 87.96 (n)
  • 90.28 (a)
ANKRD2 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ankrd2 35
  • 85.47 (n)
  • 89.33 (a)
Ankrd2 16
Ankrd2 36
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ANKRD2 36
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ANKRD2 36
  • 81 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ankrd2 35
  • 83.64 (n)
  • 88.41 (a)
chicken
(Gallus gallus)
Aves ANKRD2 35
  • 69.69 (n)
  • 65.77 (a)
ANKRD2 36
  • 59 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ANKRD2 36
  • 63 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia ankrd2-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia ankrd2 35
  • 64.42 (n)
  • 65.99 (a)
Str.12117 35
zebrafish
(Danio rerio)
Actinopterygii ankrd2 36
  • 51 (a)
OneToOne
LOC101886079 35
  • 56.64 (n)
  • 52.03 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 27 (a)
OneToMany
Species with no ortholog for ANKRD2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ANKRD2 Gene

ENSEMBL:
Gene Tree for ANKRD2 (if available)
TreeFam:
Gene Tree for ANKRD2 (if available)

Paralogs for ANKRD2 Gene

Paralogs for ANKRD2 Gene

Selected SIMAP similar genes for ANKRD2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ANKRD2: view

Variants for ANKRD2 Gene

Sequence variations from dbSNP and Humsavar for ANKRD2 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs1018727 -- 97,579,848(-) aggcc(A/G)aggtg intron-variant
rs1475757 -- 97,582,040(-) TAATA(G/T)ATGTC intron-variant
rs2275588 -- 97,581,428(+) AAAAC(A/G)CTCAG intron-variant
rs4244322 -- 97,576,631(+) ATAAT(C/T)ATTTC intron-variant
rs4244323 -- 97,576,720(+) GAGAC(C/T)GAGTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ANKRD2 Gene

Variant ID Type Subtype PubMed ID
nsv7509 CNV Insertion 18451855
nsv818782 CNV Loss 17921354

Relevant External Links for ANKRD2 Gene

HapMap Linkage Disequilibrium report
ANKRD2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANKRD2 Gene

Disorders for ANKRD2 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for ANKRD2 Gene including...

Search for ANKRD2 Gene in MalaCards »

(1) University of Copenhagen DISEASES for ANKRD2 Gene

(2) Novoseek inferred disease relationships for ANKRD2 Gene

Disease -log(P) Hits PubMed IDs
hypertrophy 26 2
tumors 0 4

Relevant External Links for ANKRD2

Genetic Association Database (GAD)
ANKRD2
Human Genome Epidemiology (HuGE) Navigator
ANKRD2
genes like me logo Genes that share disorders with ANKRD2: view

No data available for UniProtKB/Swiss-Prot for ANKRD2 Gene

Publications for ANKRD2 Gene

  1. Identification of Ankrd2, a novel skeletal muscle gene coding for a stretch-responsive ankyrin-repeat protein. (PMID: 10873377) Kemp T.J. … Coulton G.R. (Genomics 2000) 2 3 4 23
  2. The Ankrd2 protein, a link between the sarcomere and the nucleus in skeletal muscle. (PMID: 15136035) Kojic S. … Faulkner G. (J. Mol. Biol. 2004) 2 3 4 23
  3. Arpp, a new homolog of carp, is preferentially expressed in type 1 skeletal muscle fibers and is markedly induced by denervation. (PMID: 12004005) Tsukamoto Y. … Moriyama M. (Lab. Invest. 2002) 3 23
  4. Immunohistochemical analysis of a muscle ankyrin-repeat protein, Arpp, in paraffin-embedded tumors: evaluation of Arpp as a tumor marker for rhabdomyosarcoma. (PMID: 16021567) Ishiguro N. … Yoshida H. (Hum. Pathol. 2005) 3 23
  5. Characterization of human skeletal muscle Ankrd2. (PMID: 11444853) Pallavicini A. … Valle G. (Biochem. Biophys. Res. Commun. 2001) 3 4

Products for ANKRD2 Gene

Sources for ANKRD2 Gene

Back to Top

Content