ANKRD18B Gene
protein-coding GIFtS: 33
GCID: GC09P033518
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ankyrin repeat domain 18B
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Aliases
for ANKRD18B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Ankyrin Repeat Domain 18B1 2 | | BA255A11.31 | | Ankyrin Repeat Domain-Containing Protein 18B2 | | BA255A11.51 |
Export aliases for ANKRD18B gene to outside databasesPrevious GC identifers: GC09P033516 GC09U900806 |
Summaries
for ANKRD18B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for ANKRD18B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000009.11 NC_018920.1 NT_008413.18
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ANKRD18B gene promoter:
HFH-3 Cdc5 GATA-1 FOXI1 E2F E2F-1 GATA-6 POU2F1 POU2F1a ATF
Other transcription factors
Search SABiosciences Chromatin IP Primers for ANKRD18B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ANKRD18B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 9p13.3 Ensembl cytogenetic band: 9p13.3 HGNC cytogenetic band: 9p13.3ANKRD18B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 9 GeneLoc Exon Structure GeneLoc location for GC09P033518: view genomic region
(about GC identifiers)
Start:
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33,523,927 bp from pter |
End:
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33,573,007 bp from pter |
Size:
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49,081 bases |
Orientation:
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plus strand |
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Proteins
for ANKRD18B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: AN18B_HUMAN, A2A2Z9 (See
protein sequence)Recommended Name: Ankyrin repeat domain-containing protein 18B Size: 1011 amino acids; 118231 DaExplore the universe of human proteins at neXtProt for ANKRD18B: NX_A2A2Z9
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_A2A2Z9
ANKRD18B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001231681.1
ENSEMBL proteins: ENSP00000290943 ENSP00000350607
Human Recombinant Protein Products:
ANKRD18B Antibody Products:
Assay Products for ANKRD18B: |
Protein
Domains /
Families
for ANKRD18B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ANKRD18B for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry A2A2Z9ProtoNet protein and cluster: A2A2Z9 UniProtKB/Swiss-Prot: AN18B_HUMAN, A2A2Z9Similarity: Contains 5 ANK repeats |
Function
for ANKRD18B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANKRD18B |
|
Pathways & Interactions
for ANKRD18B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ANKRD18B
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for ANKRD18B (ENSP000002909434) via UniProtKB, MINT, STRING, and/or I2DAbout this table
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Drugs & Compounds
for ANKRD18B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ANKRD18B
Search CenterWatch for drugs/clinical trials and news about ANKRD18B / AN18B 
|
Transcripts
for ANKRD18B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ANKRD18B gene (2 alternative transcripts): NM_001244752.1 NM_001013728.1 Unigene Cluster for ANKRD18B: Ankyrin repeat domain 18B Hs.493710 [show with all ESTs]Unigene Representative Sequence: NM_0012447527 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000290943(uc010mjw.2) ENST00000496561 ENST00000474881 ENST00000484634
ENST00000357927 ENST00000426460 ENST00000465094
Primer
Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ANKRD18B
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat ANKRD18B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ANKRD18B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ANKRD18B |
Additional cDNA sequence: BC009440.1 5 DOTS entries: DT.95256986 DT.40240129 DT.92416099 DT.100649256 DT.121197803 1 AceView cDNA sequence: CD654308
GeneLoc Exon Structure
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Expression
for ANKRD18B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ANKRD18B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAGAATTCAG
About this image
See ANKRD18B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ANKRD18B
SOURCE GeneReport for Unigene cluster: Hs.493710
SABiosciences Custom PCR Arrays for ANKRD18B
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ANKRD18B
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat ANKRD18B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ANKRD18B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ANKRD18B | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANKRD18B |
Orthologs
for ANKRD18B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for ANKRD18B gene from 3/7 species (see all 7) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
ANKRD626 |
Uncharacterized protein |
33(a) |
1 → many |
1(26091172-26138404) |
lizard
(Anolis carolinensis) |
Reptilia |
ANKRD626 |
-- |
44(a) |
1 → many |
GL344195.1(39104-48393) |
zebrafish
(Danio rerio) |
Actinopterygii |
si:ch211-272n13.36 |
si:ch211-272n13.3 |
11(a) |
1 → many |
25(3581527-3655709) |
ENSEMBL Gene Tree for ANKRD18B (if available)
TreeFam Gene Tree for ANKRD18B (if available) |
Paralogs
for ANKRD18B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ANKRD18B gene
- POTEF2 POTEI2 ANKRD30A2 ANKRD362 ANKRD72 POTEB2 ANKRD30BL2 ANKRD20A32
- POTEH2 ENSG000001552822 ANKRD30B2 ENSG000002663022 ANKRD36C2 POTEJ2 POTEC2 ANKRD20A22
- POTEG2 ANKRD262 ANKRD622 ANKRD18A2 ENSG000001882192 POTEM2 ANKRD20A12 LOC1009963312
- CCDC144A2 POTED2 ANKRD20A42 LOC1002889662
17 SIMAP similar genes for ANKRD18B using alignment to 2 protein entries: AN18B_HUMAN (see all proteins):ANKRD19P ANKRD18A LOC644249 ANKRD30BL ANKRD36BP1 DKFZp781D1722
ANKRD26 POTEG ANKRD20A8P PRED4 ANKRD20A2 ANKRD20A1
ANKRD20A3 ANKRD20A4 CCDC144A POTEA POTEB
ANKRD18B for paralogs About GeneDecksing
5 Pseudogenes.org Pseudogenes for ANKRD18B
PGOHUM00000259666 PGOHUM00000237916 PGOHUM00000260103 PGOHUM00000243614 PGOHUM00000260530
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Genomic Variants
for ANKRD18B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 9 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ANKRD18B (33523927 - 33573007 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ANKRD18B: -- | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for ANKRD18B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for ANKRD18B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ANKRD18B gene integrated from 9 sources:
(articles sorted by number of sources associating them with ANKRD18B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)2 Humphray S.J.... Dunham I. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for ANKRD18B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing ANKRD18B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ANKRD18B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ANKRD18B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ANKRD18B | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for ANKRD18B gene:
Search GeneIP for patents involving ANKRD18B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ANKRD18B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ANKRD18B | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ANKRD18B | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ANKRD18B | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ANKRD18B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ANKRD18B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ANKRD18B |
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 | | | ANKRD18B Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANKRD18B |
|  |  |  | | | | Search ThermoFisher Antibodies for ANKRD18B |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ANKRD18B |
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