Aliases for ANKRD18B Gene
Aliases for ANKRD18B Gene
External Ids for ANKRD18B Gene
- HGNC: 23644
- Entrez Gene: 441459
- Ensembl: ENSG00000230453
- UniProtKB: A2A2Z9
Previous GeneCards Identifiers for ANKRD18B Gene
- GC09P033516
- GC09U900806
Summaries for ANKRD18B Gene
GeneCards Summary for ANKRD18B Gene
ANKRD18B (Ankyrin Repeat Domain 18B) is a Protein Coding gene. GO annotations related to this gene include nucleotide binding. An important paralog of this gene is ANKRD18A.
No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANKRD18B Gene
Genomics for ANKRD18B Gene
Regulatory Elements for ANKRD18B Gene
Enhancers for ANKRD18B Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH09G033472 | 1.4 | ENCODE dbSUPER | 10.5 | -50.8 | -50801 | 2.9 | HDGF PKNOX1 CREB3L1 ZFP64 ARID4B SIN3A DMAP1 FEZF1 YY1 ZNF302 | SMU1 TOPORS ASS1P12 TCEA1P4 ENSG00000228352 DFFBP1 GVQW1 ANKRD18B NOL6 AQP7 |
| GH09G033523 | 1 | ENCODE | 12.7 | -0.3 | -259 | 1.7 | SIN3A ZNF2 ZNF48 GLIS2 KLF7 ZNF263 SP3 REST ZNF579 GLIS1 | ANKRD18B AQP3 CYP4F26P ENSG00000228072 |
| GH09G033510 | 1 | ENCODE | 12.5 | -13.3 | -13301 | 1.9 | PKNOX1 ATF1 CREB3L1 SIN3A DMAP1 FEZF1 ZNF2 ZNF48 YY1 ZNF121 | ANKRD18B PRSS3 PIR50034 SUGT1P1 |
| GH09G033452 | 1.4 | Ensembl ENCODE dbSUPER | 8.9 | -70.7 | -70655 | 2.6 | ELF3 HDGF MLX ZFP64 ARID4B ZNF48 ZBTB7B RAD21 RARA ZNF335 | AQP3 NOL6 ANKRD18B CYP4F26P PTENP1 GC09P033453 MIR6851 |
| GH09G033505 | 1.1 | Ensembl ENCODE | 9.4 | -17.2 | -17244 | 2.3 | SIN3A GATA2 FOS USF2 CEBPB ZEB2 ZNF592 SMARCA4 IKZF1 KDM1A | NOL6 AQP3 ANKRD18B PIR50034 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around ANKRD18B on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for ANKRD18B Gene
- Chromosome:
- 9
- Start:
- 33,524,353 bp from pter
- End:
- 33,575,969 bp from pter
- Size:
- 51,617 bases
- Orientation:
- Plus strand
Genomic View for ANKRD18B Gene
Genes around ANKRD18B on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 9p13.3 by Ensembl
- 9p13.3 by Entrez Gene
- 9p13.3 by HGNC
ANKRD18B Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ANKRD18B Gene
Proteins for ANKRD18B Gene
-
Protein details for ANKRD18B Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- A2A2Z9-AN18B_HUMAN
- Recommended name:
- Ankyrin repeat domain-containing protein 18B
- Protein Accession:
- A2A2Z9
Protein attributes for ANKRD18B Gene
- Size:
- 1011 amino acids
- Molecular mass:
- 118231 Da
- Quaternary structure:
- No Data Available
Protein Expression for ANKRD18B Gene
Post-translational modifications for ANKRD18B Gene
Other Protein References for ANKRD18B Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for ANKRD18B
-
Abcam antibodies for ANKRD18B
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Protein Products
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Assay Products
No data available for DME Specific Peptides for ANKRD18B Gene
Domains & Families for ANKRD18B Gene
Gene Families for ANKRD18B Gene
Protein Domains for ANKRD18B Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for ANKRD18B Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for ANKRD18B Gene
Function for ANKRD18B Gene
Animal Model Products
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-
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CRISPR Products
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-
Santa Cruz Biotechnology (SCBT) CRISPR for ANKRD18B
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miRNA Products
- Search ViGene Biosciences for ANKRD18B
Inhibitory RNA Products
- Origene RNAi and shRNA products in human, mouse, rat for ANKRD18B
- Browse OriGene Inhibitory RNA Products For ANKRD18B
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Clone Products
- VectorBuilder custom plasmid, inducible vectors for ANKRD18B
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ANKRD18B
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ANKRD18B Gene
Localization for ANKRD18B Gene
| Compartment | Confidence |
|---|---|
| nucleus | 3 |
| mitochondrion | 2 |
| cytosol | 2 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ANKRD18B Gene
Pathways & Interactions for ANKRD18B Gene
No Data Available
No data available for Pathways by source and SIGNOR curated interactions for ANKRD18B Gene
Transcripts for ANKRD18B Gene
mRNA/cDNA for ANKRD18B Gene
- (6) REFSEQ mRNAs :
- (1) Additional mRNA sequences :
- (1) Selected AceView cDNA sequences:
- (8) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for ANKRD18B Gene
- Ankyrin repeat domain 18B:
- Representative Sequences:
CRISPR Products
- Browse CRISPR knockouts for ANKRD18B
-
Santa Cruz Biotechnology (SCBT) CRISPR for ANKRD18B
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miRNA Products
- Search ViGene Biosciences for ANKRD18B
Inhibitory RNA Products
- Origene RNAi and shRNA products in human, mouse, rat for ANKRD18B
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- Search ViGene Biosciences for ANKRD18B
Clone Products
- VectorBuilder custom plasmid, inducible vectors for ANKRD18B
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ANKRD18B
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
Expression for ANKRD18B Gene
mRNA differential expression in normal tissues according to GTEx for ANKRD18B Gene
This gene is overexpressed in Brain - Cerebellum (x11.2), Brain - Cerebellar Hemisphere (x9.5), and Testis (x5.4).
This gene is overexpressed in Tlymphocyte (37.8) and Plasma (29.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ANKRD18B Gene
NURSA nuclear receptor signaling pathways regulating expression of ANKRD18B Gene:
ANKRD18BSOURCE GeneReport for Unigene cluster for ANKRD18B Gene:
Hs.493710Primer Products
-
OriGene qPCR primer pairs for ANKRD18B
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ANKRD18B Gene
Orthologs for ANKRD18B Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | LOC746826 34 |
|
||
| ANKRD18B 35 |
|
OneToOne | |||
| dog (Canis familiaris) |
Mammalia | -- 35 |
|
ManyToMany | |
| -- 35 |
|
ManyToMany | |||
| -- 35 |
|
ManyToMany | |||
| -- 35 |
|
ManyToMany | |||
| -- 35 |
|
ManyToMany | |||
| -- 35 |
|
ManyToMany | |||
| -- 35 |
|
ManyToMany | |||
| -- 35 |
|
ManyToMany | |||
| mouse (Mus musculus) |
Mammalia | Gm1758 35 |
|
ManyToMany | |
| cow (Bos Taurus) |
Mammalia | -- 35 |
|
OneToMany | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 35 |
|
OneToMany | |
| chicken (Gallus gallus) |
Aves | -- 35 |
|
OneToMany | |
| lizard (Anolis carolinensis) |
Reptilia | -- 35 |
|
ManyToMany | |
| zebrafish (Danio rerio) |
Actinopterygii | ANKRD7 35 |
|
OneToMany |
- Species where no ortholog for ANKRD18B was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for ANKRD18B Gene
Paralogs for ANKRD18B Gene
- ANKRD18A 5
- ANKRD26 5
- ANKRD20A3 5
- ANKRD20A4 5
- ANKRD20A1 5
- ANKRD20A2 5
- ANKRD62 5
- ANKRD36 5
- ANKRD36C 5
- ANKRD36B 5
- ANKRD30B 5
- ANKRD30A 5
- ENSG00000266302 5
- CCDC144A 5
- POTEE 5
- POTEF 5
- POTEI 5
- POTEJ 5
- POTEA 5
- POTEB3 5
- LOC102723502 5
- POTEB2 5
- POTED 5
- POTEB 5
- LOC100288966 5
- POTEC 5
- POTEG 5
- POTEH 5
- POTEM 5
- ANKRD30BL 5
- ANKRD7 5
(17) SIMAP similar genes for ANKRD18B Gene using alignment to 4 proteins:
Pseudogenes.org Pseudogenes for ANKRD18B Gene
- PGOHUM00000291855
- PGOHUM00000294741
- PGOHUM00000296956
- PGOHUM00000297213
- PGOHUM00000306000
- PGOHUM00000298005
- PGOHUM00000299323
- PGOHUM00000299819
- PGOHUM00000300203
- PGOHUM00000301229
- PGOHUM00000301785
- PGOHUM00000303909
- PGOHUM00000306162
- PGOHUM00000304228
- PGOHUM00000304273
- PGOHUM00000304317
- PGOHUM00000304388
Variants for ANKRD18B Gene
| SNP ID | Clin | Chr 09 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000030004 | -- | 33,563,190(+) | TGCTA(A/C)CTAAG | intron-variant | |
| rs1000080755 | -- | 33,527,458(+) | CTGGG(A/G)TTACA | intron-variant | |
| rs1000081834 | -- | 33,562,914(+) | TAAAT(A/G)TCTGA | intron-variant | |
| rs1000231664 | -- | 33,557,431(+) | CTTAT(A/G)TTTAC | intron-variant | |
| rs1000332506 | -- | 33,550,878(+) | TAGAT(A/G)ATTTC | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3576648 | CNV | gain | 25503493 |
| nsv1024207 | CNV | gain | 25217958 |
| nsv1125318 | OTHER | inversion | 24896259 |
| nsv973205 | CNV | duplication | 23825009 |
| nsv973207 | CNV | duplication | 23825009 |
| nsv982208 | CNV | duplication | 23825009 |
Gene Damage Index Score:
5.81;
73.78% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for ANKRD18B Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- ANKRD18B
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANKRD18B Gene
Disorders for ANKRD18B Gene
Relevant External Links for ANKRD18B
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- ANKRD18B
No disorders were found for ANKRD18B Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANKRD18B Gene
Publications for ANKRD18B Gene
- Epigenetic regulation of ANKRD18B in lung cancer. (PMID: 24249358) Liu W.B. … Liu J.Y. (Mol. Carcinog. 2015) 3 64
- Initial characterization of the human central proteome. (PMID: 21269460) Burkard T.R. … Colinge J. (BMC Syst. Biol. 2011) 4 64
- DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 4 64
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64
Products for ANKRD18B Gene
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- VectorBuilder custom plasmid, inducible vectors for ANKRD18B
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ANKRD18B
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for ANKRD18B Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
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- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
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- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
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- (81) Reactome
- (82) GeneGo (Thomson Reuters)
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