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ANKRD18B Gene

protein-coding   GIFtS: 34
GCID: GC09P033518

Ankyrin Repeat Domain 18B

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ankyrin Repeat Domain 18B1 2
Ankyrin Repeat Domain-Containing Protein 18B2
bA255A11.32
bA255A11.52

External Ids:    HGNC: 236441   Entrez Gene: 4414592   Ensembl: ENSG000002304537   UniProtKB: A2A2Z93   

Export aliases for ANKRD18B gene to outside databases

Previous GC identifers: GC09P033516 GC09U900806


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ANKRD18B Gene:
ANKRD18B (ankyrin repeat domain 18B) is a protein-coding gene. An important paralog of this gene is POTEF.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000009.11  NC_018920.2  NT_008413.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the ANKRD18B gene promoter:
         HFH-3   Cdc5   GATA-1   FOXI1   E2F   E2F-1   GATA-6   POU2F1   POU2F1a   ATF   
         Other transcription factors

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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ANKRD18B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p13.3   Ensembl cytogenetic band:  9p13.3   HGNC cytogenetic band: 9p13.3

ANKRD18B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ANKRD18B gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P033518:  view genomic region     (about GC identifiers)

Start:
33,524,392 bp from pter      End:
33,573,007 bp from pter
Size:
48,616 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: AN18B_HUMAN, A2A2Z9 (See protein sequence)
Recommended Name: Ankyrin repeat domain-containing protein 18B  
Size: 1011 amino acids; 118231 Da

Explore the universe of human proteins at neXtProt for ANKRD18B: NX_A2A2Z9

Explore proteomics data for ANKRD18B at MOPED


See ANKRD18B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_001231681.1  
ENSEMBL proteins: 
 ENSP00000290943   ENSP00000474332   ENSP00000350607   ENSP00000473566  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
ANKRD: Ankyrin repeat domain containing

3 InterPro protein domains:
 IPR002110 Ankyrin_rpt
 IPR021885 DUF3496
 IPR020683 Ankyrin_rpt-contain_dom

Graphical View of Domain Structure for InterPro Entry A2A2Z9

ProtoNet protein and cluster: A2A2Z9

UniProtKB/Swiss-Prot: AN18B_HUMAN, A2A2Z9
Similarity: Contains 5 ANK repeats


Find genes that share domains with ANKRD18B           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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     Gene Ontology (GO): 2 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0000166nucleotide binding ----
GO:0005515protein binding ----
     
Find genes that share ontologies with ANKRD18B           About GenesLikeMe


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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
nucleus3
cytosol2
mitochondrion2

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ANKRD18B
Interactions:

    Search GeneGlobe Interaction Network for ANKRD18B

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

1 Interacting protein for ANKRD18B (ENSP000002909434) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
UBCENSP000003448184STRING: ENSP00000344818
About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for ANKRD18B (AN18B)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for ANKRD18B gene (2 alternative transcripts): 
NM_001244752.1  NM_001013728.1  

Unigene Cluster for ANKRD18B:

Ankyrin repeat domain 18B
Hs.493710  [show with all ESTs]
Unigene Representative Sequence: NM_001244752
8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000290943(uc010mjw.2) ENST00000496561 ENST00000474881 ENST00000484634
ENST00000605687 ENST00000357927 ENST00000426460 ENST00000465094
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Additional mRNA sequence: BC009440.1 

5 DOTS entries:

DT.95256986  DT.40240129  DT.92416099  DT.100649256  DT.121197803 

1 AceView cDNA sequence:

CD654308 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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ANKRD18B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: AAGAATTCAG
ANKRD18B Expression
About this image

ANKRD18B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

ANKRD18B Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.493710
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for ANKRD18B gene from Selected species (see all 8)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
chicken
(Gallus gallus)
Aves --
Uncharacterized protein
18(a)
1 → many
1(24064036-24111623)
lizard
(Anolis carolinensis)
Reptilia --
Uncharacterized protein
42(a)
many ↔ many
GL344195.1(38786-58936)
zebrafish
(Danio rerio)
Actinopterygii ANKRD76
ankyrin repeat domain 7
12(a)
1 → many
25(3581527-3655709) ENSDARG00000013015
        Species with no ortholog for ANKRD18B

ENSEMBL Gene Tree for ANKRD18B (if available)
TreeFam Gene Tree for ANKRD18B (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for ANKRD18B gene
POTEF2  POTEI2  ANKRD30A2  POTEB22  ANKRD362  ANKRD72  POTEB2  ANKRD30BL2  
ANKRD20A32  POTEH2  ANKRD30B2  LOC6442492  ENSG000002663022  ANKRD36C2  POTEJ2  POTEC2  
ANKRD20A22  ANKRD262  POTEG2  ANKRD622  ANKRD18A2  POTEM2  ANKRD20A12  CCDC144A2  
POTED2  POTEE2  ANKRD20A42  LOC1002889662  
17 SIMAP similar genes for ANKRD18B using alignment to 4 protein entries:     AN18B_HUMAN (see all proteins):
ANKRD19P    ANKRD18A    LOC644249    ANKRD30BL    ANKRD36BP1    ANKRD26
DKFZp781D1722    POTEG    ANKRD20A8P    PRED4    ANKRD20A2    ANKRD20A1
ANKRD20A3    ANKRD20A4    CCDC144A    POTEA    POTEB

Find genes that share paralogs with ANKRD18B           About GenesLikeMe


5 Pseudogenes.org Pseudogenes for ANKRD18B
PGOHUM00000259666 PGOHUM00000237916 PGOHUM00000260103 PGOHUM00000243614 PGOHUM00000260530


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for ANKRD18B (see all 1094)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 9 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs81811101,2
C--33522493(+) cttttG/Tctcag 1 -- us2k10--------
rs1825880561,2
--33522499(+) CTCAGC/TCAATA 1 -- us2k10--------
rs121642431,2
H--33522536(+) atctaT/Cgttta 1 -- us2k12Minor allele frequency- C:0.00NS 210
rs81812141,2
C--33522544(+) ttattC/Tattct 1 -- us2k10--------
rs2006148261,2
C--33522566(+) ACCTTC/TTATTT 1 -- us2k10--------
rs1478515261,2
C--33522575(+) TTTATG/TGATTT 1 -- us2k10--------
rs803126771,2
C--33522637(+) TAGTC-/TTTTTT 1 -- us2k10--------
rs1870566711,2
--33522670(+) GTATAC/GAGTGC 1 -- us2k10--------
rs779310411,2
C--33522675(+) GAGTGA/CGGATA 1 -- us2k11Minor allele frequency- C:0.00NA 2
rs727096351,2
C--33522676(+) AGTGCG/AGATAT 1 -- us2k13Minor allele frequency- A:0.11WA NA 240

HapMap Linkage Disequilibrium report for ANKRD18B (33524392 - 33573007 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for ANKRD18B: --
Site Specific Mutation Identification with PCR Assays
Search QIAGEN SeqTarget long-range PCR primers for resequencing ANKRD18B
DNA2.0 Custom Variant and Variant Library Synthesis for ANKRD18B

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for ANKRD18B gene integrated from 10 sources:
(articles sorted by number of sources associating them with ANKRD18B)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
  2. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
  3. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)2 Humphray S.J.... Dunham I. (Nature 2004)
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 441459 HGNC: 23644 AceView: LOC441459 Ensembl:ENSG00000230453 euGenes: HUgn441459
ECgene: ANKRD18B H-InvDB: ANKRD18B

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for ANKRD18B Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for ANKRD18B gene:
Search GeneIP for patents involving ANKRD18B

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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 inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ANKRD18B
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GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

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