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Aliases for ANKRD18B Gene

Aliases for ANKRD18B Gene

  • Ankyrin Repeat Domain 18B 2 3 5
  • Ankyrin Repeat Domain-Containing Protein 18B 3
  • BA255A11.3 3
  • BA255A11.5 3

External Ids for ANKRD18B Gene

Previous GeneCards Identifiers for ANKRD18B Gene

  • GC09P033516
  • GC09U900806

Summaries for ANKRD18B Gene

GeneCards Summary for ANKRD18B Gene

ANKRD18B (Ankyrin Repeat Domain 18B) is a Protein Coding gene. GO annotations related to this gene include nucleotide binding. An important paralog of this gene is ANKRD18A.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANKRD18B Gene

Genomics for ANKRD18B Gene

Regulatory Elements for ANKRD18B Gene

Enhancers for ANKRD18B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09G033472 1.4 ENCODE dbSUPER 10.5 -50.8 -50801 2.9 HDGF PKNOX1 CREB3L1 ZFP64 ARID4B SIN3A DMAP1 FEZF1 YY1 ZNF302 SMU1 TOPORS ASS1P12 TCEA1P4 ENSG00000228352 DFFBP1 GVQW1 ANKRD18B NOL6 AQP7
GH09G033523 1 ENCODE 12.7 -0.3 -259 1.7 SIN3A ZNF2 ZNF48 GLIS2 KLF7 ZNF263 SP3 REST ZNF579 GLIS1 ANKRD18B AQP3 CYP4F26P ENSG00000228072
GH09G033510 1 ENCODE 12.5 -13.3 -13301 1.9 PKNOX1 ATF1 CREB3L1 SIN3A DMAP1 FEZF1 ZNF2 ZNF48 YY1 ZNF121 ANKRD18B PRSS3 SUGT1P1 PIR50034
GH09G033452 1.4 Ensembl ENCODE dbSUPER 8.9 -70.7 -70655 2.6 ELF3 HDGF MLX ZFP64 ARID4B ZNF48 ZBTB7B RAD21 RARA ZNF335 AQP3 NOL6 ANKRD18B CYP4F26P PTENP1 GC09P033453 MIR6851
GH09G033505 1.1 Ensembl ENCODE 9.4 -17.2 -17244 2.3 SIN3A GATA2 FOS USF2 CEBPB ZEB2 ZNF592 SMARCA4 IKZF1 KDM1A NOL6 AQP3 ANKRD18B PIR50034
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ANKRD18B on UCSC Golden Path with GeneCards custom track

Promoters for ANKRD18B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000234413 47 1601 SIN3A ZNF2 ZNF48 GLIS2 ZNF263 SP3 REST ZNF579 GLIS1 SP7

Genomic Location for ANKRD18B Gene

Chromosome:
9
Start:
33,524,353 bp from pter
End:
33,575,969 bp from pter
Size:
51,617 bases
Orientation:
Plus strand

Genomic View for ANKRD18B Gene

Genes around ANKRD18B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANKRD18B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANKRD18B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANKRD18B Gene

Proteins for ANKRD18B Gene

  • Protein details for ANKRD18B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A2A2Z9-AN18B_HUMAN
    Recommended name:
    Ankyrin repeat domain-containing protein 18B
    Protein Accession:
    A2A2Z9

    Protein attributes for ANKRD18B Gene

    Size:
    1011 amino acids
    Molecular mass:
    118231 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ANKRD18B Gene

Post-translational modifications for ANKRD18B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ANKRD18B Gene

No data available for DME Specific Peptides for ANKRD18B Gene

Domains & Families for ANKRD18B Gene

Gene Families for ANKRD18B Gene

Protein Domains for ANKRD18B Gene

Suggested Antigen Peptide Sequences for ANKRD18B Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ANKRD18B: view

No data available for UniProtKB/Swiss-Prot for ANKRD18B Gene

Function for ANKRD18B Gene

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ANKRD18B Gene

Localization for ANKRD18B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ANKRD18B gene
Compartment Confidence
nucleus 3
mitochondrion 2
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ANKRD18B Gene

Pathways & Interactions for ANKRD18B Gene

SuperPathways for ANKRD18B Gene

No Data Available

Gene Ontology (GO) - Biological Process for ANKRD18B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ANKRD18B Gene

Drugs & Compounds for ANKRD18B Gene

No Compound Related Data Available

Transcripts for ANKRD18B Gene

mRNA/cDNA for ANKRD18B Gene

(6) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(8) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ANKRD18B Gene

Ankyrin repeat domain 18B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ANKRD18B Gene

No ASD Table

Relevant External Links for ANKRD18B Gene

GeneLoc Exon Structure for
ANKRD18B
ECgene alternative splicing isoforms for
ANKRD18B

Expression for ANKRD18B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ANKRD18B Gene

mRNA differential expression in normal tissues according to GTEx for ANKRD18B Gene

This gene is overexpressed in Brain - Cerebellum (x11.2), Brain - Cerebellar Hemisphere (x9.5), and Testis (x5.4).

Protein differential expression in normal tissues from HIPED for ANKRD18B Gene

This gene is overexpressed in Tlymphocyte (37.8) and Plasma (29.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ANKRD18B Gene



Protein tissue co-expression partners for ANKRD18B Gene

NURSA nuclear receptor signaling pathways regulating expression of ANKRD18B Gene:

ANKRD18B

SOURCE GeneReport for Unigene cluster for ANKRD18B Gene:

Hs.493710
genes like me logo Genes that share expression patterns with ANKRD18B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ANKRD18B Gene

Orthologs for ANKRD18B Gene

This gene was present in the common ancestor of chordates.

Orthologs for ANKRD18B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC746826 34
  • 98.94 (n)
ANKRD18B 35
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 35
  • 45 (a)
ManyToMany
-- 35
  • 44 (a)
ManyToMany
-- 35
  • 42 (a)
ManyToMany
-- 35
  • 33 (a)
ManyToMany
-- 35
  • 21 (a)
ManyToMany
-- 35
  • 21 (a)
ManyToMany
-- 35
  • 20 (a)
ManyToMany
-- 35
  • 13 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Gm1758 35
  • 37 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia -- 35
  • 27 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 14 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 35
  • 18 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 42 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii ANKRD7 35
  • 12 (a)
OneToMany
Species where no ortholog for ANKRD18B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ANKRD18B Gene

ENSEMBL:
Gene Tree for ANKRD18B (if available)
TreeFam:
Gene Tree for ANKRD18B (if available)

Paralogs for ANKRD18B Gene

genes like me logo Genes that share paralogs with ANKRD18B: view

Variants for ANKRD18B Gene

Sequence variations from dbSNP and Humsavar for ANKRD18B Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1000030004 -- 33,563,190(+) TGCTA(A/C)CTAAG intron-variant
rs1000080755 -- 33,527,458(+) CTGGG(A/G)TTACA intron-variant
rs1000081834 -- 33,562,914(+) TAAAT(A/G)TCTGA intron-variant
rs1000231664 -- 33,557,431(+) CTTAT(A/G)TTTAC intron-variant
rs1000332506 -- 33,550,878(+) TAGAT(A/G)ATTTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ANKRD18B Gene

Variant ID Type Subtype PubMed ID
esv3576648 CNV gain 25503493
nsv1024207 CNV gain 25217958
nsv1125318 OTHER inversion 24896259
nsv973205 CNV duplication 23825009
nsv973207 CNV duplication 23825009
nsv982208 CNV duplication 23825009

Variation tolerance for ANKRD18B Gene

Gene Damage Index Score: 5.81; 73.78% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ANKRD18B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ANKRD18B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANKRD18B Gene

Disorders for ANKRD18B Gene

Relevant External Links for ANKRD18B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ANKRD18B

No disorders were found for ANKRD18B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANKRD18B Gene

Publications for ANKRD18B Gene

  1. Epigenetic regulation of ANKRD18B in lung cancer. (PMID: 24249358) Liu W.B. … Liu J.Y. (Mol. Carcinog. 2015) 3 64
  2. Initial characterization of the human central proteome. (PMID: 21269460) Burkard T.R. … Colinge J. (BMC Syst. Biol. 2011) 4 64
  3. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 4 64
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for ANKRD18B Gene

Sources for ANKRD18B Gene

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