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Aliases for ANKRD18A Gene

Aliases for ANKRD18A Gene

  • Ankyrin Repeat Domain 18A 2 3 5
  • KIAA2015 4

External Ids for ANKRD18A Gene

Previous GeneCards Identifiers for ANKRD18A Gene

  • GC09U900260
  • GC09M038531
  • GC09M038532
  • GC09M038544
  • GC09M038524
  • GC09M038546
  • GC09M038549
  • GC09M038555
  • GC09M038563
  • GC09M038588
  • GC09M038603
  • GC09M038620
  • GC09M038642

Summaries for ANKRD18A Gene

GeneCards Summary for ANKRD18A Gene

ANKRD18A (Ankyrin Repeat Domain 18A) is a Protein Coding gene. An important paralog of this gene is POTEJ.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANKRD18A Gene

Genomics for ANKRD18A Gene

Regulatory Elements for ANKRD18A Gene

Genomic Location for ANKRD18A Gene

Chromosome:
9
Start:
38,542,965 bp from pter
End:
38,620,660 bp from pter
Size:
77,696 bases
Orientation:
Minus strand

Genomic View for ANKRD18A Gene

Genes around ANKRD18A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANKRD18A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANKRD18A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANKRD18A Gene

Proteins for ANKRD18A Gene

  • Protein details for ANKRD18A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IVF6-AN18A_HUMAN
    Recommended name:
    Ankyrin repeat domain-containing protein 18A
    Protein Accession:
    Q8IVF6
    Secondary Accessions:
    • A7MD11
    • A8MVU5
    • Q5SY86
    • Q7Z468
    • Q8NA88

    Protein attributes for ANKRD18A Gene

    Size:
    992 amino acids
    Molecular mass:
    115597 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH56266.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAC23111.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ANKRD18A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ANKRD18A Gene

Proteomics data for ANKRD18A Gene at MOPED

Post-translational modifications for ANKRD18A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ANKRD18A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ANKRD18A Gene

Domains & Families for ANKRD18A Gene

Gene Families for ANKRD18A Gene

Protein Domains for ANKRD18A Gene

Suggested Antigen Peptide Sequences for ANKRD18A Gene

Graphical View of Domain Structure for InterPro Entry

Q8IVF6

UniProtKB/Swiss-Prot:

AN18A_HUMAN :
  • Contains 5 ANK repeats.
Similarity:
  • Contains 5 ANK repeats.
genes like me logo Genes that share domains with ANKRD18A: view

Function for ANKRD18A Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ANKRD18A Gene

Localization for ANKRD18A Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ANKRD18A Gene COMPARTMENTS Subcellular localization image for ANKRD18A gene
Compartment Confidence
cytosol 2
nucleus 2
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ANKRD18A Gene

Pathways & Interactions for ANKRD18A Gene

SuperPathways for ANKRD18A Gene

No Data Available

Gene Ontology (GO) - Biological Process for ANKRD18A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ANKRD18A Gene

Drugs & Compounds for ANKRD18A Gene

No Compound Related Data Available

Transcripts for ANKRD18A Gene

Unigene Clusters for ANKRD18A Gene

Ankyrin repeat domain 18A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ANKRD18A Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b
SP1:
SP2: -
SP3:
SP4:

Relevant External Links for ANKRD18A Gene

GeneLoc Exon Structure for
ANKRD18A
ECgene alternative splicing isoforms for
ANKRD18A

Expression for ANKRD18A Gene

mRNA expression in normal human tissues for ANKRD18A Gene

mRNA differential expression in normal tissues according to GTEx for ANKRD18A Gene

This gene is overexpressed in Testis (x7.5) and Brain - Spinal cord (cervical c-1) (x5.6).

Protein differential expression in normal tissues from HIPED for ANKRD18A Gene

This gene is overexpressed in Plasma (33.9) and Urine (26.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ANKRD18A Gene



SOURCE GeneReport for Unigene cluster for ANKRD18A Gene Hs.644630

genes like me logo Genes that share expression patterns with ANKRD18A: view

Protein tissue co-expression partners for ANKRD18A Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for ANKRD18A Gene

Orthologs for ANKRD18A Gene

This gene was present in the common ancestor of chordates.

Orthologs for ANKRD18A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ANKRD18A 35
  • 98.69 (n)
  • 96.87 (a)
ANKRD18A 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 28 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 12 (a)
ManyToMany
-- 36
  • 41 (a)
ManyToMany
-- 36
  • 19 (a)
ManyToMany
-- 36
  • 20 (a)
ManyToMany
-- 36
  • 21 (a)
ManyToMany
-- 36
  • 33 (a)
ManyToMany
-- 36
  • 40 (a)
ManyToMany
-- 36
  • 44 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Gm1758 36
  • 35 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 14 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 36
  • 17 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 42 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii ANKRD7 36
  • 12 (a)
OneToMany
Species with no ortholog for ANKRD18A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ANKRD18A Gene

ENSEMBL:
Gene Tree for ANKRD18A (if available)
TreeFam:
Gene Tree for ANKRD18A (if available)

Paralogs for ANKRD18A Gene

Pseudogenes.org Pseudogenes for ANKRD18A Gene

genes like me logo Genes that share paralogs with ANKRD18A: view

Variants for ANKRD18A Gene

Sequence variations from dbSNP and Humsavar for ANKRD18A Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1832313 - 38,615,701(-) ACATT(A/G)AGGAT reference, missense
rs632200 - 38,603,191(-) GCCTG(A/C)AAATT reference, missense
rs2996347 - 38,595,889(+) AGGTA(C/T)TGAAC reference, missense
rs2799163 - 38,588,605(-) GAACT(A/G)TACTG reference, missense
rs11999308 - 38,575,615(+) GCCTT(A/G)TAGGA reference, missense

Structural Variations from Database of Genomic Variants (DGV) for ANKRD18A Gene

Variant ID Type Subtype PubMed ID
nsv8445 CNV Gain+Loss 18304495
nsv893067 CNV Gain 21882294
nsv428211 CNV Loss 18775914
dgv261e55 CNV Loss 17911159
dgv2312e1 CNV Complex 17122850
dgv2313e1 CNV Complex 17122850
nsv6539 CNV Insertion 18451855
esv27275 CNV Loss 19812545

Variation tolerance for ANKRD18A Gene

Gene Damage Index Score: 13.27; 95.29% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ANKRD18A Gene

HapMap Linkage Disequilibrium report
ANKRD18A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANKRD18A Gene

Disorders for ANKRD18A Gene

Relevant External Links for ANKRD18A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ANKRD18A

No disorders were found for ANKRD18A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANKRD18A Gene

Publications for ANKRD18A Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 67
  2. Cross-disorder genome-wide analyses suggest a complex genetic relationship between Tourette's syndrome and OCD. (PMID: 25158072) Yu D. … Pauls D.L. (Am J Psychiatry 2015) 3
  3. ANKRD18A as a novel epigenetic regulation gene in lung cancer. (PMID: 23131552) Liu W.B. … Liu J.Y. (Biochem. Biophys. Res. Commun. 2012) 3
  4. Proteomic and biochemical analysis of 14-3-3-binding proteins during C2-ceramide-induced apoptosis. (PMID: 20618440) Pozuelo-Rubio M. (FEBS J. 2010) 3
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for ANKRD18A Gene

Sources for ANKRD18A Gene

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