Aliases for ANKRD17 Gene
External Ids for ANKRD17 Gene
Previous GeneCards Identifiers for ANKRD17 Gene
This gene encodes a protein with ankyrin repeats, which are associated with protein-protein interactions. Studies in mice suggest that this protein is involved in liver development. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]
GeneCards Summary for ANKRD17 Gene
ANKRD17 (Ankyrin Repeat Domain 17) is a Protein Coding gene. Diseases associated with ANKRD17 include hand, foot and mouth disease and breast cancer. GO annotations related to this gene include RNA binding. An important paralog of this gene is TANC1.
UniProtKB/Swiss-Prot for ANKRD17 Gene
Could play pivotal roles in cell cycle and DNA regulation (PubMed:19150984). Involved in innate immune defense against viruse by positively regulating the viral dsRNA receptors DDX58 and IFIH1 signaling pathways (PubMed:22328336). Involves in NOD2- and NOD1-mediated responses to bacteria suggesting a role in innate antibacterial immune pathways too (PubMed:23711367). Target of enterovirus 71 which is the major etiological agent of HFMD (hand, foot and mouth disease) (PubMed:17276651). Could play a central role for the formation and/or maintenance of the blood vessels of the circulation system (By similarity).