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Aliases for ANKRD17 Gene

Aliases for ANKRD17 Gene

  • Ankyrin Repeat Domain 17 2 3 5
  • Serologically Defined Breast Cancer Antigen NY-BR-16 3 4
  • Gene Trap Ankyrin Repeat Protein 3 4
  • GTAR 3 4
  • NY-BR-16 3
  • KIAA0697 4
  • MASK2 3

External Ids for ANKRD17 Gene

Previous GeneCards Identifiers for ANKRD17 Gene

  • GC04M074407
  • GC04M074406
  • GC04M074305
  • GC04M074159
  • GC04M073940
  • GC04M069746

Summaries for ANKRD17 Gene

Entrez Gene Summary for ANKRD17 Gene

  • The protein encoded by this gene belongs to the family of ankyrin repeat-containing proteins, and contains two distinct arrays of ankyrin repeats in its amino-terminal region, one with 15 ankyrin repeats, and the other with 10 ankyrin repeats. It also contains a nuclear export signal, nuclear localization signal, and a cyclin-binding RXL motif. Localization of this protein to the nucleus has been shown experimentally, and interactions between this protein and cyclin-dependent kinase 2 have been observed. It has been suggested that this protein plays a role in both DNA replication and in both anti-viral and anti-bacterial innate immune pathways. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]

GeneCards Summary for ANKRD17 Gene

ANKRD17 (Ankyrin Repeat Domain 17) is a Protein Coding gene. Diseases associated with ANKRD17 include mouth disease. GO annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is TANC1.

UniProtKB/Swiss-Prot for ANKRD17 Gene

  • Could play pivotal roles in cell cycle and DNA regulation (PubMed:19150984). Involved in innate immune defense against viruse by positively regulating the viral dsRNA receptors DDX58 and IFIH1 signaling pathways (PubMed:22328336). Involves in NOD2- and NOD1-mediated responses to bacteria suggesting a role in innate antibacterial immune pathways too (PubMed:23711367). Target of enterovirus 71 which is the major etiological agent of HFMD (hand, foot and mouth disease) (PubMed:17276651). Could play a central role for the formation and/or maintenance of the blood vessels of the circulation system (By similarity).

Gene Wiki entry for ANKRD17 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANKRD17 Gene

Genomics for ANKRD17 Gene

Regulatory Elements for ANKRD17 Gene

Enhancers for ANKRD17 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ANKRD17 on UCSC Golden Path with GeneCards custom track

Promoters for ANKRD17 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ANKRD17 on UCSC Golden Path with GeneCards custom track

Genomic Location for ANKRD17 Gene

Chromosome:
4
Start:
73,073,376 bp from pter
End:
73,259,142 bp from pter
Size:
185,767 bases
Orientation:
Minus strand

Genomic View for ANKRD17 Gene

Genes around ANKRD17 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANKRD17 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANKRD17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANKRD17 Gene

Proteins for ANKRD17 Gene

  • Protein details for ANKRD17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75179-ANR17_HUMAN
    Recommended name:
    Ankyrin repeat domain-containing protein 17
    Protein Accession:
    O75179
    Secondary Accessions:
    • E7EUV3
    • G5E964
    • Q6PJ85
    • Q6PK85
    • Q6PKA2
    • Q86XI3
    • Q8NDR5
    • Q96I86
    • Q9H288
    • Q9H6J9

    Protein attributes for ANKRD17 Gene

    Size:
    2603 amino acids
    Molecular mass:
    274258 Da
    Quaternary structure:
    • Interacts with VP1 capsid protein of enterovirus 71 (EV71). Interacts (via N-terminus) with NOD2. Interacts with CDK2, MCM3, MCM5, MCM7, CDC6 and PCNA. Interacts with MAVS and IFIH1. Interacts (via the second ankyrin repeat cluster) with DDX58.
    SequenceCaution:
    • Sequence=AAG48253.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305}; Sequence=AAH04173.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAB15260.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB15260.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

    Alternative splice isoforms for ANKRD17 Gene

neXtProt entry for ANKRD17 Gene

Proteomics data for ANKRD17 Gene at MOPED

Post-translational modifications for ANKRD17 Gene

Other Protein References for ANKRD17 Gene

No data available for DME Specific Peptides for ANKRD17 Gene

Domains & Families for ANKRD17 Gene

Gene Families for ANKRD17 Gene

Protein Domains for ANKRD17 Gene

Graphical View of Domain Structure for InterPro Entry

O75179

UniProtKB/Swiss-Prot:

ANR17_HUMAN :
  • Contains 1 KH domain.
  • Contains 25 ANK repeats.
Domain:
  • Contains 1 KH domain.
Similarity:
  • Contains 25 ANK repeats.
genes like me logo Genes that share domains with ANKRD17: view

Function for ANKRD17 Gene

Molecular function for ANKRD17 Gene

UniProtKB/Swiss-Prot Function:
Could play pivotal roles in cell cycle and DNA regulation (PubMed:19150984). Involved in innate immune defense against viruse by positively regulating the viral dsRNA receptors DDX58 and IFIH1 signaling pathways (PubMed:22328336). Involves in NOD2- and NOD1-mediated responses to bacteria suggesting a role in innate antibacterial immune pathways too (PubMed:23711367). Target of enterovirus 71 which is the major etiological agent of HFMD (hand, foot and mouth disease) (PubMed:17276651). Could play a central role for the formation and/or maintenance of the blood vessels of the circulation system (By similarity).

Gene Ontology (GO) - Molecular Function for ANKRD17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IDA 19150984
genes like me logo Genes that share ontologies with ANKRD17: view
genes like me logo Genes that share phenotypes with ANKRD17: view

Animal Models for ANKRD17 Gene

MGI Knock Outs for ANKRD17:

Animal Model Products

  • Taconic Biosciences Mouse Models for ANKRD17

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ANKRD17 Gene

Localization for ANKRD17 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ANKRD17 Gene

Cytoplasm. Nucleus. Note=Detected around the nucleolus. Localized on chromatin in a cell cycle-dependent manner. {ECO:0000269 PubMed:17276651, ECO:0000269 PubMed:19150984}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ANKRD17 Gene COMPARTMENTS Subcellular localization image for ANKRD17 gene
Compartment Confidence
nucleus 5
cytosol 4
plasma membrane 3
endoplasmic reticulum 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for ANKRD17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with ANKRD17: view

Pathways & Interactions for ANKRD17 Gene

SuperPathways for ANKRD17 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ANKRD17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016032 viral process IEA --
GO:0045087 innate immune response IDA 23711367
GO:0051151 negative regulation of smooth muscle cell differentiation IEA --
GO:1900087 positive regulation of G1/S transition of mitotic cell cycle IMP 19150984
GO:1900245 positive regulation of MDA-5 signaling pathway IDA 22328336
genes like me logo Genes that share ontologies with ANKRD17: view

No data available for Pathways by source and SIGNOR curated interactions for ANKRD17 Gene

Drugs & Compounds for ANKRD17 Gene

No Compound Related Data Available

Transcripts for ANKRD17 Gene

Unigene Clusters for ANKRD17 Gene

Ankyrin repeat domain 17:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ANKRD17 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17a · 17b ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^
SP1: -
SP2:
SP3: - -
SP4: -
SP5: - -
SP6: - - - - - - - - - - - -

ExUns: 24 ^ 25 ^ 26a · 26b ^ 27 ^ 28 ^ 29 ^ 30 ^ 31a · 31b ^ 32 ^ 33 ^ 34 ^ 35a · 35b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6: - - - - - - - - -

Relevant External Links for ANKRD17 Gene

GeneLoc Exon Structure for
ANKRD17
ECgene alternative splicing isoforms for
ANKRD17

Expression for ANKRD17 Gene

mRNA expression in normal human tissues for ANKRD17 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ANKRD17 Gene

This gene is overexpressed in Lung (18.9), Platelet (15.4), Retina (8.4), and Fetal Brain (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ANKRD17 Gene



SOURCE GeneReport for Unigene cluster for ANKRD17 Gene Hs.601206

mRNA Expression by UniProt/SwissProt for ANKRD17 Gene

O75179-ANR17_HUMAN
Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expression patterns with ANKRD17: view

Protein tissue co-expression partners for ANKRD17 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for ANKRD17 Gene

Orthologs for ANKRD17 Gene

This gene was present in the common ancestor of animals.

Orthologs for ANKRD17 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ANKRD17 35
  • 95.61 (n)
  • 98.19 (a)
ANKRD17 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ANKRD17 35
  • 96.5 (n)
  • 98.94 (a)
ANKRD17 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ankrd17 35
  • 92.9 (n)
  • 96.47 (a)
Ankrd17 16
Ankrd17 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ANKRD17 35
  • 99.81 (n)
  • 99.85 (a)
ANKRD17 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ankrd17 35
  • 92.29 (n)
  • 96.7 (a)
oppossum
(Monodelphis domestica)
Mammalia ANKRD17 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ANKRD17 36
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves ANKRD17 35
  • 84.48 (n)
  • 93.55 (a)
ANKRD17 36
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ANKRD17 36
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ankrd17 35
  • 76.43 (n)
  • 84.44 (a)
Str.15599 35
fruit fly
(Drosophila melanogaster)
Insecta mask 36
  • 28 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.13317 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 69 (a)
OneToMany
Species with no ortholog for ANKRD17:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ANKRD17 Gene

ENSEMBL:
Gene Tree for ANKRD17 (if available)
TreeFam:
Gene Tree for ANKRD17 (if available)

Paralogs for ANKRD17 Gene

genes like me logo Genes that share paralogs with ANKRD17: view

Variants for ANKRD17 Gene

Sequence variations from dbSNP and Humsavar for ANKRD17 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs2306059 - 73,077,014(+) AGCAT(A/G)AGGGC reference, missense
rs10092 -- 73,075,026(-) TGTCA(C/T)GAAGA utr-variant-3-prime
rs1534450 -- 73,149,092(+) CATTA(A/C)AAAAA intron-variant
rs1996057 -- 73,221,476(+) TCAAA(C/T)AGATT intron-variant
rs1913149 -- 73,105,335(+) ACATA(C/T)ACCTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ANKRD17 Gene

Variant ID Type Subtype PubMed ID
nsv523169 CNV Gain 19592680
dgv5634n71 CNV Loss 21882294
dgv5635n71 CNV Loss 21882294

Variation tolerance for ANKRD17 Gene

Residual Variation Intolerance Score: 0.175% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.36; 41.88% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ANKRD17 Gene

HapMap Linkage Disequilibrium report
ANKRD17

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANKRD17 Gene

Disorders for ANKRD17 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ANKRD17 Gene - From: GeneCards

Disorder Aliases PubMed IDs
mouth disease
  • mouth diseases
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ANKRD17

Genetic Association Database (GAD)
ANKRD17
Human Genome Epidemiology (HuGE) Navigator
ANKRD17
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ANKRD17
genes like me logo Genes that share disorders with ANKRD17: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ANKRD17 Gene

Publications for ANKRD17 Gene

  1. Identification and functional analysis of a novel cyclin e/cdk2 substrate ankrd17. (PMID: 19150984) Deng M. … Ye X. (J. Biol. Chem. 2009) 3 4 23 67
  2. A gene trap integration provides an early in situ marker for hepatic specification of the foregut endoderm. (PMID: 11165478) Watt A.J. … Forrester L.M. (Mech. Dev. 2001) 2 3
  3. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. (PMID: 25609649) Li X. … Chen J. (Mol. Syst. Biol. 2015) 3
  4. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for ANKRD17 Gene

Sources for ANKRD17 Gene

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