Aliases for ANKRD17 Gene
Aliases for ANKRD17 Gene
External Ids for ANKRD17 Gene
- HGNC: 23575
- Entrez Gene: 26057
- Ensembl: ENSG00000132466
- OMIM: 615929
- UniProtKB: O75179
Previous GeneCards Identifiers for ANKRD17 Gene
- GC04M074407
- GC04M074406
- GC04M074305
- GC04M074159
- GC04M073940
- GC04M069746
Summaries for ANKRD17 Gene
-
The protein encoded by this gene belongs to the family of ankyrin repeat-containing proteins, and contains two distinct arrays of ankyrin repeats in its amino-terminal region, one with 15 ankyrin repeats, and the other with 10 ankyrin repeats. It also contains a nuclear export signal, nuclear localization signal, and a cyclin-binding RXL motif. Localization of this protein to the nucleus has been shown experimentally, and interactions between this protein and cyclin-dependent kinase 2 have been observed. It has been suggested that this protein plays a role in both DNA replication and in both anti-viral and anti-bacterial innate immune pathways. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]
GeneCards Summary for ANKRD17 Gene
ANKRD17 (Ankyrin Repeat Domain 17) is a Protein Coding gene. Diseases associated with ANKRD17 include Mouth Disease. GO annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is ANKHD1-EIF4EBP3.
UniProtKB/Swiss-Prot for ANKRD17 Gene
-
Could play pivotal roles in cell cycle and DNA regulation (PubMed:19150984). Involved in innate immune defense against viruse by positively regulating the viral dsRNA receptors DDX58 and IFIH1 signaling pathways (PubMed:22328336). Involves in NOD2- and NOD1-mediated responses to bacteria suggesting a role in innate antibacterial immune pathways too (PubMed:23711367). Target of enterovirus 71 which is the major etiological agent of HFMD (hand, foot and mouth disease) (PubMed:17276651). Could play a central role for the formation and/or maintenance of the blood vessels of the circulation system (By similarity).
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANKRD17 Gene
Genomics for ANKRD17 Gene
Regulatory Elements for ANKRD17 Gene
Enhancers for ANKRD17 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around ANKRD17 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the ANKRD17 gene promoter:
Regulatory Element Products
Genomic Location for ANKRD17 Gene
- Chromosome:
- 4
- Start:
- 73,073,376 bp from pter
- End:
- 73,259,142 bp from pter
- Size:
- 185,767 bases
- Orientation:
- Minus strand
Genomic View for ANKRD17 Gene
Genes around ANKRD17 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 4q13.3 by Ensembl
- 4q13.3 by Entrez Gene
- 4q13.3 by HGNC
ANKRD17 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ANKRD17 Gene
Proteins for ANKRD17 Gene
-
Protein details for ANKRD17 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O75179-ANR17_HUMAN
- Recommended name:
- Ankyrin repeat domain-containing protein 17
- Protein Accession:
- O75179
- E7EUV3
- G5E964
- Q6PJ85
- Q6PK85
- Q6PKA2
- Q86XI3
- Q8NDR5
- Q96I86
- Q9H288
- Q9H6J9
Protein attributes for ANKRD17 Gene
- Size:
- 2603 amino acids
- Molecular mass:
- 274258 Da
- Quaternary structure:
-
- Interacts with VP1 capsid protein of enterovirus 71 (EV71). Interacts (via N-terminus) with NOD2. Interacts with CDK2, MCM3, MCM5, MCM7, CDC6 and PCNA. Interacts with MAVS and IFIH1. Interacts (via the second ankyrin repeat cluster) with DDX58.
- SequenceCaution:
-
- Sequence=AAG48253.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305}; Sequence=AAH04173.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAB15260.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB15260.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};
Protein Expression for ANKRD17 Gene
Post-translational modifications for ANKRD17 Gene
- Phosphorylated by CDK2.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for ANKRD17 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for ANKRD17
-
Abcam antibodies for ANKRD17
- Invitrogen Antibodies for ANKRD17
- antibodies-online Antibodies for ANKRD17: See all 32
- Search GeneTex for Antibodies for ANKRD17
Protein Products
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- Origene Custom Protein Services for ANKRD17
- antibodies-online Proteins for ANKRD17: See all 4
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- Search GeneTex for Proteins for ANKRD17
-
Abcam proteins for ANKRD17
Assay Products
- antibodies-online Kits for ANKRD17: See all 9
No data available for DME Specific Peptides for ANKRD17 Gene
Domains & Families for ANKRD17 Gene
Gene Families for ANKRD17 Gene
Protein Domains for ANKRD17 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for ANKRD17 Gene
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for ANKRD17 Gene
Function for ANKRD17 Gene
Molecular function for ANKRD17 Gene
- UniProtKB/Swiss-Prot Function:
- Could play pivotal roles in cell cycle and DNA regulation (PubMed:19150984). Involved in innate immune defense against viruse by positively regulating the viral dsRNA receptors DDX58 and IFIH1 signaling pathways (PubMed:22328336). Involves in NOD2- and NOD1-mediated responses to bacteria suggesting a role in innate antibacterial immune pathways too (PubMed:23711367). Target of enterovirus 71 which is the major etiological agent of HFMD (hand, foot and mouth disease) (PubMed:17276651). Could play a central role for the formation and/or maintenance of the blood vessels of the circulation system (By similarity).
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003676 | nucleic acid binding | IEA | -- |
| GO:0003682 | chromatin binding | IDA | 19150984 |
| GO:0003723 | RNA binding | IDA | 22658674 |
| GO:0005515 | protein binding | IPI | 19150984 |
Phenotypes for ANKRD17 Gene
- MGI mutant phenotypes for ANKRD17:
- inferred from 3 alleles
- GenomeRNAi human phenotypes for ANKRD17:
-
- Increased vaccinia virus (VACV) infection
- shRNA abundance <= 50%
- Lamellipodia cells
- Decreased ionizing radiation sensitivity
- Dynamic nuclei (hole, folded or small irregular)
- Resistant to vaccinia virus (VACV-A4L) infection
- Decreased shRNA abundance (Z-score < -2)
- Increased shRNA abundance (Z-score > 2)
- Decreased vaccinia virus (VACV-LREV ) gene expression
Animal Models for ANKRD17 Gene
- MGI Knock Outs for ANKRD17:
-
- Ankrd17 tm1.1Yty
Animal Model Products
-
Taconic Biosciences Mouse Models for ANKRD17
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-
-
ViGene Biosciences lentiviral particle packaged cDNA for ANKRD17 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for ANKRD17 gene
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CRISPR Products
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OriGene CRISPR knockouts for ANKRD17
-
Santa Cruz Biotechnology (SCBT) CRISPR for ANKRD17
- GenScript: Design CRISPR guide RNA sequences for ANKRD17
miRNA for ANKRD17 Gene
- miRTarBase miRNAs that target ANKRD17
-
- hsa-mir-23b-3p (MIRT023473)
- hsa-mir-1-3p (MIRT023980)
- hsa-mir-16-5p (MIRT031910)
- hsa-mir-424-5p (MIRT042449)
- hsa-mir-186-5p (MIRT045049)
- hsa-let-7c-5p (MIRT051812)
- hsa-let-7b-5p (MIRT052283)
- hsa-let-7a-5p (MIRT052463)
- hsa-mir-664b-3p (MIRT449010)
- hsa-mir-579-3p (MIRT449011)
- hsa-mir-549a (MIRT449012)
- hsa-mir-4699-3p (MIRT449013)
- hsa-mir-582-5p (MIRT449014)
- hsa-mir-101-3p (MIRT449015)
- hsa-mir-885-5p (MIRT449016)
- hsa-mir-6504-3p (MIRT449017)
miRNA Products
- Search ViGene Biosciences for ANKRD17
Inhibitory RNA Products
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Clone Products
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for ANKRD17
-
ViGene Biosciences adenoviral particle packaged cDNA for ANKRD17 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for ANKRD17 gene
-
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Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ANKRD17 Gene
Localization for ANKRD17 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ANKRD17 Gene
- Cytoplasm. Nucleus. Note=Detected around the nucleolus. Localized on chromatin in a cell cycle-dependent manner. {ECO:0000269 PubMed:17276651, ECO:0000269 PubMed:19150984}.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 4 |
| plasma membrane | 3 |
| mitochondrion | 1 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000785 | chromatin | IDA | 19150984 |
| GO:0005634 | nucleus | IEA,IDA | 19150984 |
| GO:0005737 | cytoplasm | IDA,IEA | 22328336 |
| GO:0016020 | membrane | IDA | 19946888 |
| GO:0031965 | nuclear membrane | IDA | -- |
Pathways & Interactions for ANKRD17 Gene
No Data Available
Interacting Proteins for ANKRD17 Gene
Selected Interacting proteins:
ENSP00000351416
O75179-ANR17_HUMAN
for ANKRD17 Gene via
STRING
MINT
IID
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001955 | blood vessel maturation | IEA | -- |
| GO:0002376 | immune system process | IEA | -- |
| GO:0006275 | regulation of DNA replication | IMP | 19150984 |
| GO:0016032 | viral process | IEA | -- |
| GO:0042742 | defense response to bacterium | IDA | 23711367 |
No data available for Pathways by source and SIGNOR curated interactions for ANKRD17 Gene
Transcripts for ANKRD17 Gene
mRNA/cDNA for ANKRD17 Gene
- (14) REFSEQ mRNAs :
- (18) Additional mRNA sequences :
- (351) Selected AceView cDNA sequences:
- (11) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for ANKRD17 Gene
CRISPR Products
-
OriGene CRISPR knockouts for ANKRD17
-
Santa Cruz Biotechnology (SCBT) CRISPR for ANKRD17
- GenScript: Design CRISPR guide RNA sequences for ANKRD17
miRNA Products
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Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for ANKRD17
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-
ViGene Biosciences ready-to-package AAV shRNAs for ANKRD17 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for ANKRD17
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ANKRD17
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16a | · | 16b | ^ | 17a | · | 17b | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 | ^ | 22 | ^ | 23 | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | - | - | - | - | - | - | - |
| ExUns: | 24 | ^ | 25 | ^ | 26a | · | 26b | ^ | 27 | ^ | 28 | ^ | 29 | ^ | 30 | ^ | 31a | · | 31b | ^ | 32 | ^ | 33 | ^ | 34 | ^ | 35a | · | 35b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||||||||||||||||||
| SP2: | |||||||||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||||||
| SP5: | |||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | - | - | - | - |
Expression for ANKRD17 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Gonad (Reproductive System)
- Testis Somatic Cells Primitive Gonad
-
Testis (Reproductive System)
- Testis Somatic Cells Primitive Gonad
This gene is overexpressed in Lung (18.9), Platelet (15.4), Retina (8.4), and Fetal Brain (6.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ANKRD17 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of ANKRD17 Gene:
ANKRD17SOURCE GeneReport for Unigene cluster for ANKRD17 Gene:
Hs.601206mRNA Expression by UniProt/SwissProt for ANKRD17 Gene:
O75179-ANR17_HUMAN
Tissue specificity:
Ubiquitously expressed.
Evidence on tissue expression from TISSUES for ANKRD17 Gene
- Nervous system(4.9)
- Liver(4.3)
- Muscle(4.3)
- Lung(2.3)
Primer Products
-
OriGene qPCR primer pairs for ANKRD17
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ANKRD17 Gene
Orthologs for ANKRD17 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ANKRD17 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | ANKRD17 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | ANKRD17 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Ankrd17 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Ankrd17 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | ANKRD17 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | ANKRD17 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | ANKRD17 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | ANKRD17 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | ankrd17 34 |
|
||
| Str.15599 34 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | mask 35 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
OneToMany | |
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.13317 34 |
|
- Species where no ortholog for ANKRD17 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for ANKRD17 Gene
Paralogs for ANKRD17 Gene
(14) SIMAP similar genes for ANKRD17 Gene using alignment to 5 proteins:
Variants for ANKRD17 Gene
| SNP ID | Clin | Chr 04 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000023133 | -- | 73,177,997(+) | TATCA(C/T)TATCA | intron-variant | |
| rs1000028889 | -- | 73,220,013(+) | TTTCA(C/T)GTTTT | intron-variant | |
| rs1000040193 | -- | 73,110,467(+) | CCAGT(C/T)TTCTG | intron-variant | |
| rs1000050398 | -- | 73,252,783(+) | TTCAG(C/T)ATGAA | intron-variant | |
| rs1000075269 | -- | 73,088,146(+) | TAAAA(A/G)CAGAT | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3600984 | CNV | gain | 21293372 |
| esv3600985 | CNV | gain | 21293372 |
| esv3600989 | CNV | loss | 21293372 |
| esv3600990 | CNV | loss | 21293372 |
| esv3600991 | CNV | loss | 21293372 |
| nsv1000509 | CNV | gain | 25217958 |
| nsv523169 | CNV | gain | 19592680 |
| nsv966284 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
0.175% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.36;
41.88% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for ANKRD17 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- ANKRD17
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANKRD17 Gene
Disorders for ANKRD17 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| mouth disease |
|
|
Search ANKRD17 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for ANKRD17
No data available for UniProtKB/Swiss-Prot and Genatlas for ANKRD17 Gene
Publications for ANKRD17 Gene
- Identification and functional analysis of a novel cyclin e/cdk2 substrate ankrd17. (PMID: 19150984) Deng M. … Ye X. (J. Biol. Chem. 2009) 3 4 22 64
- A role for the Ankyrin repeat containing protein Ankrd17 in Nod1- and Nod2-mediated inflammatory responses. (PMID: 23711367) Menning M. … Kufer T.A. (FEBS Lett. 2013) 3 4 64
- Ankrd17 positively regulates RIG-I-like receptor (RLR)-mediated immune signaling. (PMID: 22328336) Wang Y. … Ye X. (Eur. J. Immunol. 2012) 3 4 64
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
- The VP1 structural protein of enterovirus 71 interacts with human ornithine decarboxylase and gene trap ankyrin repeat. (PMID: 17276651) Yeo W.M. … Chow V.T.K. (Microb. Pathog. 2007) 3 4 64
Products for ANKRD17 Gene
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- VectorBuilder custom plasmid, inducible vectors for ANKRD17
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ANKRD17
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for ANKRD17 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
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