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Aliases for ANKRD17 Gene

Aliases for ANKRD17 Gene

  • Ankyrin Repeat Domain 17 2 3
  • Serologically Defined Breast Cancer Antigen NY-BR-16 3 4
  • Gene Trap Ankyrin Repeat Protein 3 4
  • GTAR 3 4
  • Ankyrin Repeat Domain-Containing Protein 17 3
  • NY-BR-16 3
  • KIAA0697 4
  • MASK2 3

External Ids for ANKRD17 Gene

Summaries for ANKRD17 Gene

Entrez Gene Summary for ANKRD17 Gene

  • This gene encodes a protein with ankyrin repeats, which are associated with protein-protein interactions. Studies in mice suggest that this protein is involved in liver development. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]

GeneCards Summary for ANKRD17 Gene

ANKRD17 (Ankyrin Repeat Domain 17) is a Protein Coding gene. Diseases associated with ANKRD17 include hand, foot and mouth disease and breast cancer. GO annotations related to this gene include RNA binding. An important paralog of this gene is TANC1.

UniProtKB/Swiss-Prot for ANKRD17 Gene

  • Could play pivotal roles in cell cycle and DNA regulation (PubMed:19150984). Involved in innate immune defense against viruse by positively regulating the viral dsRNA receptors DDX58 and IFIH1 signaling pathways (PubMed:22328336). Involves in NOD2- and NOD1-mediated responses to bacteria suggesting a role in innate antibacterial immune pathways too (PubMed:23711367). Target of enterovirus 71 which is the major etiological agent of HFMD (hand, foot and mouth disease) (PubMed:17276651). Could play a central role for the formation and/or maintenance of the blood vessels of the circulation system (By similarity).

Gene Wiki entry for ANKRD17 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANKRD17 Gene

Genomics for ANKRD17 Gene

Genomic Location for ANKRD17 Gene

Start:
73,073,376 bp from pter
End:
73,259,141 bp from pter
Size:
185,766 bases
Orientation:
Minus strand

Genomic View for ANKRD17 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ANKRD17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANKRD17 Gene

Regulatory Elements for ANKRD17 Gene

Proteins for ANKRD17 Gene

  • Protein details for ANKRD17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75179-ANR17_HUMAN
    Recommended name:
    Ankyrin repeat domain-containing protein 17
    Protein Accession:
    O75179
    Secondary Accessions:
    • E7EUV3
    • G5E964
    • Q6PJ85
    • Q6PK85
    • Q6PKA2
    • Q86XI3
    • Q8NDR5
    • Q96I86
    • Q9H288
    • Q9H6J9

    Protein attributes for ANKRD17 Gene

    Size:
    2603 amino acids
    Molecular mass:
    274258 Da
    Quaternary structure:
    • Interacts with VP1 capsid protein of enterovirus 71 (EV71). Interacts (via N-terminus) with NOD2. Interacts with CDK2, MCM3, MCM5, MCM7, CDC6 and PCNA. Interacts with MAVS and IFIH1. Interacts (via the second ankyrin repeat cluster) with DDX58.
    SequenceCaution:
    • Sequence=AAG48253.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305}; Sequence=AAH04173.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAB15260.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB15260.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

    Alternative splice isoforms for ANKRD17 Gene

neXtProt entry for ANKRD17 Gene

Proteomics data for ANKRD17 Gene at MOPED

Post-translational modifications for ANKRD17 Gene

Other Protein References for ANKRD17 Gene

No data available for DME Specific Peptides for ANKRD17 Gene

Domains for ANKRD17 Gene

Gene Families for ANKRD17 Gene

HGNC:
  • ANKRD :Ankyrin repeat domain containing

Protein Domains for ANKRD17 Gene

Graphical View of Domain Structure for InterPro Entry

O75179

UniProtKB/Swiss-Prot:

ANR17_HUMAN
Domain:
  • Contains 1 KH domain.:
    • O75179
Similarity:
  • Contains 25 ANK repeats.:
    • O75179
genes like me logo Genes that share domains with ANKRD17: view

Function for ANKRD17 Gene

Molecular function for ANKRD17 Gene

UniProtKB/Swiss-Prot Function: Could play pivotal roles in cell cycle and DNA regulation (PubMed:19150984). Involved in innate immune defense against viruse by positively regulating the viral dsRNA receptors DDX58 and IFIH1 signaling pathways (PubMed:22328336). Involves in NOD2- and NOD1-mediated responses to bacteria suggesting a role in innate antibacterial immune pathways too (PubMed:23711367). Target of enterovirus 71 which is the major etiological agent of HFMD (hand, foot and mouth disease) (PubMed:17276651). Could play a central role for the formation and/or maintenance of the blood vessels of the circulation system (By similarity).

Gene Ontology (GO) - Molecular Function for ANKRD17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003682 chromatin binding IDA 19150984
GO:0003723 RNA binding --
GO:0005515 protein binding IPI 19150984
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with ANKRD17: view
genes like me logo Genes that share phenotypes with ANKRD17: view

Animal Models for ANKRD17 Gene

MGI Knock Outs for ANKRD17:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for ANKRD17 Gene

Localization for ANKRD17 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ANKRD17 Gene

Cytoplasm. Nucleus. Note=Detected around the nucleolus. Localized on chromatin in a cell cycle-dependent manner. {ECO:0000269 PubMed:17276651, ECO:0000269 PubMed:19150984}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ANKRD17 Gene COMPARTMENTS Subcellular localization image for ANKRD17 gene
Compartment Confidence
nucleus 5
cytosol 3
plasma membrane 3
endoplasmic reticulum 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for ANKRD17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000785 chromatin IDA 19150984
GO:0005634 nucleus IDA 19150984
GO:0005737 cytoplasm IDA --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with ANKRD17: view

Pathways for ANKRD17 Gene

SuperPathways for ANKRD17 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ANKRD17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001955 blood vessel maturation IEA --
GO:0006275 regulation of DNA replication IMP 19150984
GO:0016032 viral process IEA --
GO:0042742 defense response to bacterium IDA 23711367
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IDA 22328336
genes like me logo Genes that share ontologies with ANKRD17: view

No data available for Pathways by source for ANKRD17 Gene

Transcripts for ANKRD17 Gene

Unigene Clusters for ANKRD17 Gene

Ankyrin repeat domain 17:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ANKRD17 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17a · 17b ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^
SP1: -
SP2:
SP3: - -
SP4: -
SP5: - -
SP6: - - - - - - - - - - - -

ExUns: 24 ^ 25 ^ 26a · 26b ^ 27 ^ 28 ^ 29 ^ 30 ^ 31a · 31b ^ 32 ^ 33 ^ 34 ^ 35a · 35b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6: - - - - - - - - -

Relevant External Links for ANKRD17 Gene

GeneLoc Exon Structure for
ANKRD17
ECgene alternative splicing isoforms for
ANKRD17

Expression for ANKRD17 Gene

mRNA expression in normal human tissues for ANKRD17 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ANKRD17 Gene

SOURCE GeneReport for Unigene cluster for ANKRD17 Gene Hs.601206

mRNA Expression by UniProt/SwissProt for ANKRD17 Gene

O75179-ANR17_HUMAN
Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expressions with ANKRD17: view

No data available for mRNA differential expression in normal tissues for ANKRD17 Gene

Orthologs for ANKRD17 Gene

This gene was present in the common ancestor of animals.

Orthologs for ANKRD17 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ANKRD17 35
  • 99.81 (n)
  • 99.85 (a)
ANKRD17 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ANKRD17 35
  • 95.61 (n)
  • 98.19 (a)
ANKRD17 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ANKRD17 35
  • 96.5 (n)
  • 98.94 (a)
ANKRD17 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ankrd17 35
  • 92.9 (n)
  • 96.47 (a)
Ankrd17 16
Ankrd17 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ANKRD17 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ANKRD17 36
  • 71 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ankrd17 35
  • 92.29 (n)
  • 96.7 (a)
chicken
(Gallus gallus)
Aves ANKRD17 35
  • 84.48 (n)
  • 93.55 (a)
ANKRD17 36
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ANKRD17 36
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ankrd17 35
  • 76.43 (n)
  • 84.44 (a)
Str.15599 35
fruit fly
(Drosophila melanogaster)
Insecta mask 36
  • 28 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.13317 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 69 (a)
OneToMany
Species with no ortholog for ANKRD17:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ANKRD17 Gene

ENSEMBL:
Gene Tree for ANKRD17 (if available)
TreeFam:
Gene Tree for ANKRD17 (if available)

Paralogs for ANKRD17 Gene

genes like me logo Genes that share paralogs with ANKRD17: view

Variants for ANKRD17 Gene

Sequence variations from dbSNP and Humsavar for ANKRD17 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs10092 -- 73,075,026(-) TGTCA(C/T)GAAGA utr-variant-3-prime
rs1534450 -- 73,149,092(+) CATTA(A/C)AAAAA intron-variant
rs1913149 -- 73,105,335(+) ACATA(C/T)ACCTA intron-variant
rs1913150 -- 73,109,008(+) caaaa(A/G)tttat intron-variant
rs1996057 -- 73,221,476(+) TCAAA(C/T)AGATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ANKRD17 Gene

Variant ID Type Subtype PubMed ID
nsv523169 CNV Gain 19592680
dgv5634n71 CNV Loss 21882294
dgv5635n71 CNV Loss 21882294

Relevant External Links for ANKRD17 Gene

HapMap Linkage Disequilibrium report
ANKRD17

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANKRD17 Gene

Disorders for ANKRD17 Gene

(1) University of Copenhagen DISEASES for ANKRD17 Gene

Relevant External Links for ANKRD17

Genetic Association Database (GAD)
ANKRD17
Human Genome Epidemiology (HuGE) Navigator
ANKRD17
genes like me logo Genes that share disorders with ANKRD17: view

No data available for UniProtKB/Swiss-Prot for ANKRD17 Gene

Publications for ANKRD17 Gene

  1. Identification and functional analysis of a novel cyclin e/cdk2 substrate ankrd17. (PMID: 19150984) Deng M. … Ye X. (J. Biol. Chem. 2009) 3 4 23
  2. Humoral immunity to human breast cancer: antigen definition and quantitative analysis of mRNA expression. (PMID: 12747765) Scanlan M.J. … Old L.J. (Cancer Immun. 2001) 3 4
  3. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9734811) Ishikawa K. … Ohara O. (DNA Res. 1998) 3 4
  4. A gene trap integration provides an early in situ marker for hepatic specification of the foregut endoderm. (PMID: 11165478) Watt A.J. … Forrester L.M. (Mech. Dev. 2001) 2 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for ANKRD17 Gene

Sources for ANKRD17 Gene

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