Aliases for ANKRD16 Gene
External Ids for ANKRD16 Gene
- HGNC: 23471
- Entrez Gene: 54522
- Ensembl: ENSG00000134461
- UniProtKB: Q6P6B7
Previous GeneCards Identifiers for ANKRD16 Gene
- GC10M005907
- GC10M005942
- GC10M005905
- GC10M005906
- GC10M005830
- GC10M005909
- GC10M005911
- GC10M005912
- GC10M005914
- GC10M005916
- GC10M005918
- GC10M005920
Summaries for ANKRD16 Gene
GeneCards Summary for ANKRD16 Gene
ANKRD16 (Ankyrin Repeat Domain 16) is a Protein Coding gene. An important paralog of this gene is RNASEL.
No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANKRD16 Gene
Genomics for ANKRD16 Gene
Regulatory Elements for ANKRD16 Gene
Enhancers for ANKRD16 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around ANKRD16 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for ANKRD16 Gene
- Chromosome:
- 10
- Start:
- 5,861,617 bp from pter
- End:
- 5,889,906 bp from pter
- Size:
- 28,290 bases
- Orientation:
- Minus strand
Genomic View for ANKRD16 Gene
Genes around ANKRD16 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 10p15.1 by Ensembl
- 10p15.1 by Entrez Gene
- 10p15.1 by HGNC
ANKRD16 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ANKRD16 Gene
Proteins for ANKRD16 Gene
-
Protein details for ANKRD16 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q6P6B7-ANR16_HUMAN
- Recommended name:
- Ankyrin repeat domain-containing protein 16
- Protein Accession:
- Q6P6B7
- A6NEF0
- F8WEI4
- Q9NT01
Protein attributes for ANKRD16 Gene
- Size:
- 361 amino acids
- Molecular mass:
- 39284 Da
- Quaternary structure:
- No Data Available
Protein Expression for ANKRD16 Gene
Post-translational modifications for ANKRD16 Gene
Other Protein References for ANKRD16 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for ANKRD16
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-
Abcam antibodies for ANKRD16
- Invitrogen Antibodies for ANKRD16
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Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for ANKRD16
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- Novus Biologicals proteins for ANKRD16
- Search GeneTex for Proteins for ANKRD16
-
Abcam proteins for ANKRD16
Assay Products
No data available for DME Specific Peptides for ANKRD16 Gene
Domains & Families for ANKRD16 Gene
Gene Families for ANKRD16 Gene
Protein Domains for ANKRD16 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for ANKRD16 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for ANKRD16 Gene
Function for ANKRD16 Gene
Phenotypes for ANKRD16 Gene
Animal Model Products
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-
-
ViGene Biosciences lentiviral particle packaged cDNA for ANKRD16 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for ANKRD16 gene
- Search ViGene Biosciences for ANKRD16
CRISPR Products
-
OriGene CRISPR knockouts for ANKRD16
-
Santa Cruz Biotechnology (SCBT) CRISPR for ANKRD16
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miRNA for ANKRD16 Gene
- miRTarBase miRNAs that target ANKRD16
miRNA Products
- Search ViGene Biosciences for ANKRD16
Inhibitory RNA Products
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-
ViGene Biosciences ready-to-package AAV shRNAs for ANKRD16 gene
Clone Products
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for ANKRD16
-
ViGene Biosciences adenoviral particle packaged cDNA for ANKRD16 gene
-
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-
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Flow Cytometry Products
No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ANKRD16 Gene
Localization for ANKRD16 Gene
| Compartment | Confidence |
|---|---|
| nucleus | 3 |
| cytosol | 3 |
| extracellular | 2 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ANKRD16 Gene
Pathways & Interactions for ANKRD16 Gene
No Data Available
No data available for Pathways by source and SIGNOR curated interactions for ANKRD16 Gene
Transcripts for ANKRD16 Gene
mRNA/cDNA for ANKRD16 Gene
- (4) REFSEQ mRNAs :
- (4) Additional mRNA sequences :
- (76) Selected AceView cDNA sequences:
- (4) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for ANKRD16 Gene
CRISPR Products
-
OriGene CRISPR knockouts for ANKRD16
-
Santa Cruz Biotechnology (SCBT) CRISPR for ANKRD16
- GenScript: Design CRISPR guide RNA sequences for ANKRD16
miRNA Products
- Search ViGene Biosciences for ANKRD16
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for ANKRD16
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-
ViGene Biosciences ready-to-package AAV shRNAs for ANKRD16 gene
Clone Products
- Sino Biological Human cDNA Clone for ANKRD16
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for ANKRD16
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ANKRD16
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
Expression for ANKRD16 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
This gene is overexpressed in Platelet (42.4) and Bone (20.9).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ANKRD16 Gene
NURSA nuclear receptor signaling pathways regulating expression of ANKRD16 Gene:
ANKRD16SOURCE GeneReport for Unigene cluster for ANKRD16 Gene:
Hs.289828Primer Products
-
OriGene qPCR primer pairs for ANKRD16
-
OriGene qPCR primer pairs and template standards for ANKRD16
No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ANKRD16 Gene
Orthologs for ANKRD16 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ANKRD16 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | ANKRD16 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Ankrd16 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Ankrd16 34 |
|
||
| dog (Canis familiaris) |
Mammalia | ANKRD16 34 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | ANKRD16 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | ANKRD16 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | ANKRD16 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | ANKRD16 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | ankrd16 34 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.14968 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | ankrd16 34 35 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | pain 35 |
|
OneToOne | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
OneToOne |
- Species where no ortholog for ANKRD16 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for ANKRD16 Gene
(4) SIMAP similar genes for ANKRD16 Gene using alignment to 1 proteins:
Variants for ANKRD16 Gene
| SNP ID | Clin | Chr 10 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000007378 | -- | 5,881,978(+) | CACTG(C/T)GCCTG | intron-variant | |
| rs1000020695 | -- | 5,862,257(+) | GCTGC(A/T)TCTGT | utr-variant-3-prime | |
| rs1000030463 | -- | 5,862,546(+) | ACTGG(C/T)ACACC | utr-variant-3-prime | |
| rs1000152350 | -- | 5,871,959(+) | ATGGC(C/T)CAACC | intron-variant | |
| rs1000169381 | -- | 5,876,093(+) | TGGCC(A/G)GGCAG | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv1e49 | CNV | loss | 18971310 |
| esv2668731 | CNV | deletion | 23128226 |
| esv2676037 | CNV | deletion | 23128226 |
| esv3545829 | CNV | deletion | 23714750 |
| esv3622238 | CNV | loss | 21293372 |
| esv3622239 | CNV | loss | 21293372 |
| nsv1118070 | CNV | deletion | 24896259 |
| nsv437655 | CNV | loss | 16327808 |
| nsv519773 | CNV | loss | 19592680 |
| nsv520941 | CNV | loss | 19592680 |
| nsv549904 | CNV | loss | 21841781 |
| nsv549905 | CNV | loss | 21841781 |
| nsv549906 | CNV | loss | 21841781 |
| nsv5654 | CNV | deletion | 18451855 |
| nsv825229 | CNV | gain | 20364138 |
| nsv831775 | CNV | loss | 17160897 |
Residual Variation Intolerance Score:
82% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
6.97;
79.90% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for ANKRD16 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- ANKRD16
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANKRD16 Gene
Disorders for ANKRD16 Gene
Relevant External Links for ANKRD16
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- ANKRD16
No disorders were found for ANKRD16 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANKRD16 Gene
Publications for ANKRD16 Gene
- The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 3 4 64
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
- A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64
- Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie A.G. … Butte N.F. (PLoS ONE 2012) 3 64
- Genome-wide association study identifies five new breast cancer susceptibility loci. (PMID: 20453838) Turnbull C. … Easton D.F. (Nat. Genet. 2010) 3 64
Products for ANKRD16 Gene
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- Custom Antibody ServicesOriGene Antibodies for ANKRD16
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- OriGene qPCR primer pairs for ANKRD16
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- Novus Biologicals Antibodies for ANKRD16
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- Cyagen custom Knockout/knockin (KOKI) mouse models for ANKRD16
- VectorBuilder custom plasmid, inducible vectors for ANKRD16
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ANKRD16
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for ANKRD16 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
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- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer