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Aliases for ANKRD16 Gene

Aliases for ANKRD16 Gene

  • Ankyrin Repeat Domain 16 2 3 5

External Ids for ANKRD16 Gene

Previous GeneCards Identifiers for ANKRD16 Gene

  • GC10M005907
  • GC10M005942
  • GC10M005905
  • GC10M005906
  • GC10M005830
  • GC10M005909
  • GC10M005911
  • GC10M005912
  • GC10M005914
  • GC10M005916
  • GC10M005918
  • GC10M005920

Summaries for ANKRD16 Gene

GeneCards Summary for ANKRD16 Gene

ANKRD16 (Ankyrin Repeat Domain 16) is a Protein Coding gene. An important paralog of this gene is TRPA1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANKRD16 Gene

Genomics for ANKRD16 Gene

Regulatory Elements for ANKRD16 Gene

Enhancers for ANKRD16 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around ANKRD16 on UCSC Golden Path with GeneCards custom track

Promoters for ANKRD16 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for ANKRD16 Gene

5,861,617 bp from pter
5,889,906 bp from pter
28,290 bases
Minus strand

Genomic View for ANKRD16 Gene

Genes around ANKRD16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANKRD16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANKRD16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANKRD16 Gene

Proteins for ANKRD16 Gene

  • Protein details for ANKRD16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ankyrin repeat domain-containing protein 16
    Protein Accession:
    Secondary Accessions:
    • A6NEF0
    • F8WEI4
    • Q9NT01

    Protein attributes for ANKRD16 Gene

    361 amino acids
    Molecular mass:
    39284 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ANKRD16 Gene


neXtProt entry for ANKRD16 Gene

Post-translational modifications for ANKRD16 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ANKRD16 Gene

No data available for DME Specific Peptides for ANKRD16 Gene

Domains & Families for ANKRD16 Gene

Gene Families for ANKRD16 Gene

Protein Domains for ANKRD16 Gene

Suggested Antigen Peptide Sequences for ANKRD16 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 9 ANK repeats.
  • Contains 9 ANK repeats.
genes like me logo Genes that share domains with ANKRD16: view

Function for ANKRD16 Gene

genes like me logo Genes that share phenotypes with ANKRD16: view

Animal Model Products

CRISPR Products

miRNA for ANKRD16 Gene

miRTarBase miRNAs that target ANKRD16

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ANKRD16 Gene

Localization for ANKRD16 Gene

Subcellular locations from

Jensen Localization Image for ANKRD16 Gene COMPARTMENTS Subcellular localization image for ANKRD16 gene
Compartment Confidence
cytosol 3
nucleus 3
extracellular 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ANKRD16 Gene

Pathways & Interactions for ANKRD16 Gene

SuperPathways for ANKRD16 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ANKRD16 Gene


No data available for Pathways by source and SIGNOR curated interactions for ANKRD16 Gene

Drugs & Compounds for ANKRD16 Gene

No Compound Related Data Available

Transcripts for ANKRD16 Gene

Unigene Clusters for ANKRD16 Gene

Ankyrin repeat domain 16:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ANKRD16 Gene

No ASD Table

Relevant External Links for ANKRD16 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ANKRD16 Gene

mRNA expression in normal human tissues for ANKRD16 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ANKRD16 Gene

This gene is overexpressed in Platelet (42.4) and Bone (20.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ANKRD16 Gene

NURSA nuclear receptor signaling pathways regulating expression of ANKRD16 Gene:


SOURCE GeneReport for Unigene cluster for ANKRD16 Gene:

genes like me logo Genes that share expression patterns with ANKRD16: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for ANKRD16 Gene

Orthologs for ANKRD16 Gene

This gene was present in the common ancestor of animals.

Orthologs for ANKRD16 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ANKRD16 34
  • 82.78 (n)
  • 83.61 (a)
ANKRD16 35
  • 81 (a)
(Canis familiaris)
Mammalia ANKRD16 34
  • 78.41 (n)
  • 77.27 (a)
ANKRD16 35
  • 77 (a)
(Mus musculus)
Mammalia Ankrd16 34
  • 82.54 (n)
  • 82.63 (a)
Ankrd16 16
Ankrd16 35
  • 82 (a)
(Pan troglodytes)
Mammalia ANKRD16 34
  • 99.54 (n)
  • 99.45 (a)
ANKRD16 35
  • 99 (a)
(Rattus norvegicus)
Mammalia Ankrd16 34
  • 82.44 (n)
  • 82.44 (a)
(Monodelphis domestica)
Mammalia ANKRD16 35
  • 74 (a)
(Ornithorhynchus anatinus)
Mammalia ANKRD16 35
  • 68 (a)
(Gallus gallus)
Aves ANKRD16 34
  • 69.66 (n)
  • 69.86 (a)
ANKRD16 35
  • 64 (a)
(Anolis carolinensis)
Reptilia ANKRD16 35
  • 64 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ankrd16 34
  • 64.35 (n)
  • 61.56 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.14968 34
(Danio rerio)
Actinopterygii ankrd16 34
  • 62.36 (n)
  • 60.96 (a)
ankrd16 35
  • 58 (a)
fruit fly
(Drosophila melanogaster)
Insecta pain 35
  • 7 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 38 (a)
Species where no ortholog for ANKRD16 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ANKRD16 Gene

Gene Tree for ANKRD16 (if available)
Gene Tree for ANKRD16 (if available)

Paralogs for ANKRD16 Gene

Paralogs for ANKRD16 Gene

(4) SIMAP similar genes for ANKRD16 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ANKRD16: view

Variants for ANKRD16 Gene

Sequence variations from dbSNP and Humsavar for ANKRD16 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1052420 - 5,878,158(-) CCTTC(A/G)GGGCT reference, missense, utr-variant-3-prime
VAR_033503 -
rs582359 -- 5,887,077(+) ATTTT(A/G)TGCTA intron-variant
rs583630 -- 5,879,395(+) cccag(A/G)aggtg intron-variant
rs584000 -- 5,879,432(+) CACTG(A/C)CCTCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ANKRD16 Gene

Variant ID Type Subtype PubMed ID
dgv1e49 CNV loss 18971310
esv2668731 CNV deletion 23128226
esv2676037 CNV deletion 23128226
esv3545829 CNV deletion 23714750
esv3622238 CNV loss 21293372
esv3622239 CNV loss 21293372
nsv1118070 CNV deletion 24896259
nsv437655 CNV loss 16327808
nsv519773 CNV loss 19592680
nsv520941 CNV loss 19592680
nsv549904 CNV loss 21841781
nsv549905 CNV loss 21841781
nsv549906 CNV loss 21841781
nsv5654 CNV deletion 18451855
nsv825229 CNV gain 20364138
nsv831775 CNV loss 17160897

Variation tolerance for ANKRD16 Gene

Residual Variation Intolerance Score: 82% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.97; 79.90% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ANKRD16 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANKRD16 Gene

Disorders for ANKRD16 Gene

Relevant External Links for ANKRD16

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ANKRD16 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANKRD16 Gene

Publications for ANKRD16 Gene

  1. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 3 4 65
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65
  3. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 65
  4. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie A.G. … Butte N.F. (PLoS ONE 2012) 3 65
  5. Genome-wide association study identifies five new breast cancer susceptibility loci. (PMID: 20453838) Turnbull C. … Easton D.F. (Nat. Genet. 2010) 3 65

Products for ANKRD16 Gene

Sources for ANKRD16 Gene

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