Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ANKRD13D Gene

Aliases for ANKRD13D Gene

  • Ankyrin Repeat Domain 13 Family, Member D 2 3

External Ids for ANKRD13D Gene

Summaries for ANKRD13D Gene

GeneCards Summary for ANKRD13D Gene

ANKRD13D (Ankyrin Repeat Domain 13 Family, Member D) is a Protein Coding gene. An important paralog of this gene is ANKRD13B.

UniProtKB/Swiss-Prot for ANKRD13D Gene

  • Ubiquitin-binding protein that specifically recognizes and binds Lys-63-linked ubiquitin. Does not bind Lys-48-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANKRD13D Gene

Genomics for ANKRD13D Gene

Genomic Location for ANKRD13D Gene

Start:
67,288,547 bp from pter
End:
67,302,485 bp from pter
Size:
13,939 bases
Orientation:
Plus strand

Genomic View for ANKRD13D Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ANKRD13D Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANKRD13D Gene

Regulatory Elements for ANKRD13D Gene

Proteins for ANKRD13D Gene

  • Protein details for ANKRD13D Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZTN6-AN13D_HUMAN
    Recommended name:
    Ankyrin repeat domain-containing protein 13D
    Protein Accession:
    Q6ZTN6
    Secondary Accessions:
    • D6RCN6
    • Q0VAK0
    • Q0VGC3
    • Q6ZVD0
    • Q86SU1

    Protein attributes for ANKRD13D Gene

    Size:
    518 amino acids
    Molecular mass:
    58476 Da
    Quaternary structure:
    • Interacts with EGFR (ubiquitinated); the interaction is direct and may regulate EGFR internalization.

    Alternative splice isoforms for ANKRD13D Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ANKRD13D Gene

Proteomics data for ANKRD13D Gene at MOPED

Post-translational modifications for ANKRD13D Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys27, Lys159, Lys268, and Lys322

Other Protein References for ANKRD13D Gene

No data available for DME Specific Peptides for ANKRD13D Gene

Domains for ANKRD13D Gene

Gene Families for ANKRD13D Gene

HGNC:
  • ANKRD :Ankyrin repeat domain containing

Protein Domains for ANKRD13D Gene

Suggested Antigen Peptide Sequences for ANKRD13D Gene

Graphical View of Domain Structure for InterPro Entry

Q6ZTN6

UniProtKB/Swiss-Prot:

AN13D_HUMAN
Domain:
  • Contains 4 UIM (ubiquitin-interacting motif) domains.:
    • Q6ZTN6
genes like me logo Genes that share domains with ANKRD13D: view

Function for ANKRD13D Gene

Molecular function for ANKRD13D Gene

UniProtKB/Swiss-Prot Function: Ubiquitin-binding protein that specifically recognizes and binds Lys-63-linked ubiquitin. Does not bind Lys-48-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane.

Gene Ontology (GO) - Molecular Function for ANKRD13D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with ANKRD13D: view

miRNA for ANKRD13D Gene

miRTarBase miRNAs that target ANKRD13D

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ANKRD13D Gene

Localization for ANKRD13D Gene

Subcellular locations from UniProtKB/Swiss-Prot for ANKRD13D Gene

Cell membrane. Late endosome. Note=Interaction with EGFR may enhance association with the cell membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ANKRD13D Gene COMPARTMENTS Subcellular localization image for ANKRD13D gene
Compartment Confidence
nucleus 2
cytosol 1
extracellular 1
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for ANKRD13D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome --
GO:0005770 late endosome IEA --
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with ANKRD13D: view

Pathways for ANKRD13D Gene

SuperPathways for ANKRD13D Gene

No Data Available

Interacting Proteins for ANKRD13D Gene

Gene Ontology (GO) - Biological Process for ANKRD13D Gene

None

No data available for Pathways by source for ANKRD13D Gene

Transcripts for ANKRD13D Gene

Unigene Clusters for ANKRD13D Gene

Ankyrin repeat domain 13 family, member D:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ANKRD13D Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16a · 16b ^
SP1: - - - - - - - - - -
SP2: - - - - - - - - - -
SP3: - - -
SP4: - -
SP5: - - -
SP6:
SP7: - - -
SP8: - -
SP9: - - - - -
SP10: -
SP11: - - -
SP12:

ExUns: 17 ^ 18 ^ 19
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for ANKRD13D Gene

GeneLoc Exon Structure for
ANKRD13D
ECgene alternative splicing isoforms for
ANKRD13D

Expression for ANKRD13D Gene

mRNA expression in normal human tissues for ANKRD13D Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ANKRD13D Gene

This gene is overexpressed in Whole Blood (7.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ANKRD13D Gene

SOURCE GeneReport for Unigene cluster for ANKRD13D Gene Hs.438673

genes like me logo Genes that share expressions with ANKRD13D: view

No data available for mRNA Expression by UniProt/SwissProt for ANKRD13D Gene

Orthologs for ANKRD13D Gene

This gene was present in the common ancestor of animals.

Orthologs for ANKRD13D Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ANKRD13D 35
  • 99.23 (n)
  • 99.34 (a)
ANKRD13D 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ANKRD13D 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ANKRD13D 35
  • 90.63 (n)
  • 94.05 (a)
ANKRD13D 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ankrd13d 35
  • 87.38 (n)
  • 92.4 (a)
Ankrd13d 16
Ankrd13d 36
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ANKRD13D 36
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ANKRD13D 36
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ankrd13d 35
  • 87.49 (n)
  • 93.06 (a)
chicken
(Gallus gallus)
Aves ANKRD13D 36
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ANKRD13D 36
  • 75 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii ANKRD13D 36
  • 70 (a)
OneToOne
LOC562931 35
  • 67.35 (n)
  • 74.11 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010677 35
  • 56.38 (n)
  • 47.07 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG15118 35
  • 54.86 (n)
  • 46.8 (a)
CG15118 36
  • 42 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C18F10.7 36
  • 36 (a)
OneToMany
Species with no ortholog for ANKRD13D:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ANKRD13D Gene

ENSEMBL:
Gene Tree for ANKRD13D (if available)
TreeFam:
Gene Tree for ANKRD13D (if available)

Paralogs for ANKRD13D Gene

Paralogs for ANKRD13D Gene

Selected SIMAP similar genes for ANKRD13D Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ANKRD13D: view

Variants for ANKRD13D Gene

Sequence variations from dbSNP and Humsavar for ANKRD13D Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs1574103 -- 67,290,128(-) GACAC(A/G)GCCAG reference, synonymous-codon, nc-transcript-variant, utr-variant-5-prime
rs2004225 -- 67,291,228(-) AGGTG(A/T)GTGCC intron-variant
rs2051458 -- 67,291,116(+) gcttt(C/T)tgagg intron-variant
rs2298815 -- 67,301,388(-) GCGGC(A/G)ACAGC synonymous-codon, reference, nc-transcript-variant, downstream-variant-500B
rs3802744 -- 67,299,401(+) CTGCC(A/G)CCTCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ANKRD13D Gene

Variant ID Type Subtype PubMed ID
nsv897796 CNV Loss 21882294
nsv897797 CNV Loss 21882294
dgv1192n71 CNV Loss 21882294
nsv897800 CNV Loss 21882294
nsv468603 CNV Loss 19166990
nsv897801 CNV Loss 21882294
nsv897802 CNV Loss 21882294
esv7980 OTHER Inversion 19470904
nsv897803 CNV Loss 21882294

Relevant External Links for ANKRD13D Gene

HapMap Linkage Disequilibrium report
ANKRD13D

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANKRD13D Gene

Disorders for ANKRD13D Gene

Relevant External Links for ANKRD13D

Genetic Association Database (GAD)
ANKRD13D
Human Genome Epidemiology (HuGE) Navigator
ANKRD13D
genes like me logo Genes that share disorders with ANKRD13D: view

No data available for UniProtKB/Swiss-Prot for ANKRD13D Gene

Publications for ANKRD13D Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 48
  4. The Ankrd 13 family of UIM-bearing proteins regulates EGF receptor endocytosis from the plasma membrane. (PMID: 22298428) Tanno H. … Komada M. (Mol. Biol. Cell 2012) 3 4
  5. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor T.D. … Sakaki Y. (Nature 2006) 4

Products for ANKRD13D Gene

Sources for ANKRD13D Gene

Back to Top

Content