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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ANKRD13D Gene

protein-coding   GIFtS: 48
GCID: GC11P067056

ankyrin repeat domain 13 family, member D

 Explore 1 disease affiliated with
ANKRD13D via our new
 Human Malady Compendium 
Biological research products
for ANKRD13D
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Ankyrin Repeat Domain 13 Family, Member D1 2
Ankyrin Repeat Domain-Containing Protein 13D2

External Ids:    HGNC: 278801   Entrez Gene: 3386922   Ensembl: ENSG000001729327   UniProtKB: Q6ZTN63   
ORGUL members:         
NONCODE:n408905    

Export aliases for ANKRD13D gene to outside databases

Previous GC identifers: GC11P066814 GC11P063385


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

  --

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.1  NT_167190.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ANKRD13D gene promoter:
         NF-1   p53   Nkx2-5   Nkx5-1   Ik-3   NF-kappaB   Arnt   E47   NF-kappaB2   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidANKRD13D promoter sequence
   Search SABiosciences Chromatin IP Primers for ANKRD13D

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ANKRD13D


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13.2   Ensembl cytogenetic band:  11q13.2   HGNC cytogenetic band: 11q13.2

ANKRD13D Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ANKRD13D gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P067056:  view genomic region     (about GC identifiers)

Start:
67,056,018 bp from pter      End:
67,069,956 bp from pter
Size:
13,939 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: AN13D_HUMAN, Q6ZTN6 (See protein sequence)
Recommended Name: Ankyrin repeat domain-containing protein 13D  
Size: 518 amino acids; 58476 Da
Secondary accessions: D6RCN6 Q0VAK0 Q0VGC3 Q6ZVD0 Q86SU1
Alternative splicing: 3 isoforms:  Q6ZTN6-1   Q6ZTN6-2   Q6ZTN6-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ANKRD13D: NX_Q6ZTN6

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q6ZTN6

  • ANKRD13D Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_997237.2  
    ENSEMBL proteins: 
     ENSP00000402616   ENSP00000310874   ENSP00000444404   ENSP00000443977   ENSP00000427130  

    Human Recombinant Protein Products: 
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    Uscn Proteins for ANKRD13D


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    Uscn ELISAs and CLIAs for ANKRD13D


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ANKRD13D for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR003903 Ubiquitin-int_motif
     IPR021832 ANKRD13

    Graphical View of Domain Structure for InterPro Entry Q6ZTN6

    ProtoNet protein and cluster: Q6ZTN6

    1 Blocks protein family: IPB003903 Ubiquitin interacting motif

    UniProtKB/Swiss-Prot: AN13D_HUMAN, Q6ZTN6
    Similarity: Contains 3 UIM (ubiquitin-interacting motif) repeats


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    miRNA
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    2 QIAGEN miScript miRNA Assays for microRNAs that regulate ANKRD13D:
    hsa-miR-130b* hsa-miR-340
    SwitchGear 3'UTR luciferase reporter plasmidANKRD13D 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ANKRD13D

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for ANKRD13D (Q6ZTN62, 3 ENSP000003108744) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBQLN4Q9NRR52, 3, ENSP000003572924MINT-2879367 MINT-2879386 I2D: score=3 STRING: ENSP00000357292
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ANKRD13D
    Search CenterWatch for drugs/clinical trials and news about ANKRD13D / AN13D 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ANKRD13D gene: 
    NM_207354.2  

    Unigene Cluster for ANKRD13D:

    Ankyrin repeat domain 13 family, member D
    Hs.438673  [show with all ESTs]
    Unigene Representative Sequence: AK091614
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000447274 ENST00000512101 ENST00000513460 ENST00000308440(uc001okc.2)
    ENST00000514166 ENST00000514779 ENST00000506531 ENST00000504729 ENST00000504186
    ENST00000508417 ENST00000512231(uc001okg.2 uc001okh.2) ENST00000513750
    ENST00000508422 ENST00000507915 ENST00000506119 ENST00000515828(uc001oki.2)
    ENST00000504236 ENST00000511455(uc001okd.2 uc001oke.2)

    miRNA
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    2 QIAGEN miScript miRNA Assays for microRNAs that regulate ANKRD13D:
    hsa-miR-130b* hsa-miR-340
    SwitchGear 3'UTR luciferase reporter plasmidANKRD13D 3' UTR sequence
    Inhib. RNA
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    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ANKRD13D (see all 6)
    OriGene siRNA: ANKRD13D
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ANKRD13D
    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ANKRD13D (see all 3)
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    GenScript: all cDNA clones in your preferred vector: ANKRD13D (NM_207354)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ANKRD13D
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ANKRD13D 
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ANKRD13D
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ANKRD13D

    Additional cDNA sequence: 

    AF147342.1 AK027313.1 AK057566.1 AK057681.1 AK091614.1 AK096277.1 AK124721.1 BC044239.1 
    BC110419.1 BC121024.1 BC121025.2 NR_030767.1 

    16 DOTS entries:

    DT.100813951  DT.214155  DT.101982096  DT.102831963  DT.100813956  DT.70100836  DT.102831962  DT.100767714 
    DT.101982097  DT.95274951  DT.100027152  DT.100027153  DT.120705813  DT.40222936  DT.75102231  DT.92425144 

    24/171 AceView cDNA sequences (see all 171):

    BX437778 R53223 CA448360 BQ880420 CB216878 BI760480 AL536957 AW958008 
    BU956212 BM455416 BM702628 BQ278895 AI571196 BX372369 AW090340 BM974779 
    AK096277 Z41900 AI631484 BU857875 BC044239 AW081499 BU178587 BF983690 

    GeneLoc Exon Structure

    5/12 Alternative Splicing Database (ASD) splice patterns (SP) for ANKRD13D (see all 12)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16a · 16b ^
    SP1:                    -     -     -                 -     -           -                             -           -                 -     -                     
    SP2:                    -     -     -                 -     -           -                             -           -                 -     -                     
    SP3:                                                                                                              -                 -     -                     
    SP4:                                                                                                                                -     -                     
    SP5:                                                                                                  -                             -     -                     

    ExUns: 17 ^ 18 ^ 19
    SP1:                  
    SP2:                  
    SP3:                  
    SP4:                  
    SP5:                  


    ECgene alternative splicing isoforms for ANKRD13D

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ANKRD13D expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GAGCGCAACG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See ANKRD13D Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ANKRD13D

    SOURCE GeneReport for Unigene cluster: Hs.438673
        SABiosciences Custom PCR Arrays for ANKRD13D
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANKRD13D

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ANKRD13D gene from 6/21 species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    lizard
    (Anolis carolinensis)
    Reptilia ANKRD13D6
    --
    76(a)
    1 ↔ 1
    1(92790491-92815843)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5629311 ankyrin repeat domain-containing protein 13D-like 67(n)
    73.52(a)
      562931  XM_686296.3  XP_691388.3 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG151181 CG15118 54.92(n)
    46.8(a)
      37199  NM_166326.1  NP_725853.1 
    worm
    (Caenorhabditis elegans)
    Secernentea C18F10.76
    Protein C18F10.7, isoform a
    32(a)
    1 → many
    III(6275957-6278305)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G620506
    AT3G242106
    (see all 5)
    ankyrin repeat-containing protein
    (see all 5)
    20(a)
    19(a)
    (see all 5)
    many ↔ many
    many ↔ many
    (see all 5)
    1(22936127-22939024)
    3(8753474-8756065)
    rice
    (Oryza sativa)
    Liliopsida --
    --
    (see all 3)
    ankyrin repeat domain containing protein, expresse...
    ankyrin repeat domain containing protein, expresse...
    (see all 3)
    19(a)
    18(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    7(19613248-19616481)
    2(34613941-34617796)


    ENSEMBL Gene Tree for ANKRD13D (if available)
    TreeFam Gene Tree for ANKRD13D (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ANKRD13D gene
    ANKRD13B2  ANKRD13A2  ANKRD13C2  
    3 SIMAP similar genes for ANKRD13D using alignment to 1 protein entry:     AN13D_HUMAN:
    ANKRD13B    ANKRD13A    ANKRD13

    ANKRD13D for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/225 NCBI SNPs in ANKRD13D are shown (see all 225    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1469451431,2
    --67054771(+) TGAATA/TCAAGA 1 -- us2k10--------
    rs1509603631,2
    --67054818(+) TTGGTG/TTGGGA 2 -- us2k10--------
    rs1410257831,2
    --67054939(+) TAACCC/TATCCC 2 -- us2k10--------
    rs1893872491,2
    --67055004(+) CCAGAA/CCTGCC 2 -- us2k10--------
    rs71048981,2
    C,H--67055178(+) CAGACG/AGGAAG 2 -- us2k14Minor allele frequency- A:0.00NS EA 418
    rs1819263321,2
    --67055369(+) GGGAAC/TGGACA 2 -- us2k10--------
    rs617639751,2
    F--67055375(+) GGACAG/CTCTCT 2 -- us2k11Minor allele frequency- C:0.00NS 556
    rs585309461,2
    C,F,--67055482(+) CAAGAT/CGGCAG 2 -- us2k17Minor allele frequency- C:0.06NS WA NA CSA EA 918
    rs617639771,2
    C,--67055686(+) GGTGGC/TAAAGT 2 -- us2k13Minor allele frequency- T:0.01NS WA 668
    rs617639781,2
    C,F,--67055725(+) CTACAG/AGGAGA 2 -- us2k11Minor allele frequency- A:0.00NS 548

    HapMap Linkage Disequilibrium report for ANKRD13D (67056018 - 67069956 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for ANKRD13D
         1 Inversion: 59697

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ANKRD13D
    DNA2.0 Custom Variant and Variant Library Synthesis for ANKRD13D

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ANKRD13D for disorders           About GeneDecksing

    1 disease for ANKRD13D:    About MalaCards
    ataxia

    Human Genome Epidemiology (HuGE) Navigator: ANKRD13D (3 documents)

    Export disorders for ANKRD13D gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ANKRD13D gene, integrated from 9 sources (see all 17):
    (articles sorted by number of sources associating them with ANKRD13D)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. The Ankrd 13 family of UIM-bearing proteins regulates EGF receptor endocytosis from the plasma membrane. (PubMed id 22298428)1 Tanno H....Komada M. (2012)
    4. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    5. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    6. Ubiquitin ligase substrate identification through qua ntitative proteomics at both the protein and peptide levels. (PubMed id 21987572)1 Lee K.A....Doedens J.R. (2011)
    7. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    8. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1 Bailey S.D....Anand S. (2010)
    9. Comparison of substrate specificity of the ubiquitin ligases Nedd4 and Nedd4-2 using proteome arrays. (PubMed id 19953087)1 Persaud A....Rotin D. (2009)
    10. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 338692 HGNC: 27880 AceView: LOC338692 Ensembl:ENSG00000172932 euGenes: HUgn338692
    ECgene: ANKRD13D H-InvDB: ANKRD13D

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ANKRD13D Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ANKRD13D gene:
    Search GeneIP for patents involving ANKRD13D

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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