Aliases for ANKRD13C Gene
Aliases for ANKRD13C Gene
External Ids for ANKRD13C Gene
- HGNC: 25374
- Entrez Gene: 81573
- Ensembl: ENSG00000118454
- OMIM: 615125
- UniProtKB: Q8N6S4
Previous GeneCards Identifiers for ANKRD13C Gene
- GC01M070439
- GC01M070500
- GC01M070724
- GC01M068835
Summaries for ANKRD13C Gene
GeneCards Summary for ANKRD13C Gene
ANKRD13C (Ankyrin Repeat Domain 13C) is a Protein Coding gene. GO annotations related to this gene include receptor binding. An important paralog of this gene is ANKRD13D.
UniProtKB/Swiss-Prot for ANKRD13C Gene
-
Acts as a molecular chaperone for G protein-coupled receptors, regulating their biogenesis and exit from the ER.
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANKRD13C Gene
Genomics for ANKRD13C Gene
Regulatory Elements for ANKRD13C Gene
Enhancers for ANKRD13C Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH01G070352 | 1.2 | ENCODE | 11.3 | +0.6 | 600 | 3.6 | HDGF PKNOX1 MLX CREB3L1 ARNT ARID4B SIN3A ZNF2 YY1 ZNF766 | HHLA3 ANKRD13C LRRC40 GC01M070275 |
| GH01G070226 | 0.8 | FANTOM5 dbSUPER | 4 | +128.4 | 128370 | 0.4 | POLR2A IKZF1 FOS | LRRC40 SRSF11 ANKRD13C GC01P070230 ENSG00000228988 |
| GH01G070281 | 0.6 | FANTOM5 | 1.3 | +73.5 | 73538 | 0.2 | HDAC1 SMARCE1 STAT1 GATA2 ZNF366 ZEB2 | SRSF11 ANKRD13C GC01M070275 GC01P070230 |
| GH01G070340 | 0.4 | FANTOM5 | 0.4 | +13.7 | 13678 | 0.4 | ZBTB33 | ANKRD13C GC01M070275 |
| GH01G070319 | 0.5 | ENCODE | 0.3 | +34.7 | 34682 | 2.0 | JUND CEBPG ZBTB33 | HHLA3 GC01M070275 ANKRD13C |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around ANKRD13C on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the ANKRD13C gene promoter:
Regulatory Element Products
Genomic Location for ANKRD13C Gene
- Chromosome:
- 1
- Start:
- 70,259,002 bp from pter
- End:
- 70,354,788 bp from pter
- Size:
- 95,787 bases
- Orientation:
- Minus strand
Genomic View for ANKRD13C Gene
Genes around ANKRD13C on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1p31.1 by Ensembl
- 1p31.1 by Entrez Gene
- 1p31.1 by HGNC
ANKRD13C Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ANKRD13C Gene
Proteins for ANKRD13C Gene
-
Protein details for ANKRD13C Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8N6S4-AN13C_HUMAN
- Recommended name:
- Ankyrin repeat domain-containing protein 13C
- Protein Accession:
- Q8N6S4
- B3KQ97
- Q5VYH4
- Q5VYH5
- Q6PJE4
- Q9H0N9
Protein attributes for ANKRD13C Gene
- Size:
- 541 amino acids
- Molecular mass:
- 60818 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=BAG51959.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
Protein Expression for ANKRD13C Gene
Post-translational modifications for ANKRD13C Gene
Other Protein References for ANKRD13C Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
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- antibodies-online Antibodies for ANKRD13C: See all 23
- GeneTex ANKRD13C antibody for ANKRD13C
Protein Products
-
OriGene Purified Proteins for ANKRD13C
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- antibodies-online Proteins for ANKRD13C: See all 4
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Assay Products
- antibodies-online Kits for ANKRD13C: See all 9
No data available for DME Specific Peptides for ANKRD13C Gene
Domains & Families for ANKRD13C Gene
Gene Families for ANKRD13C Gene
Protein Domains for ANKRD13C Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for ANKRD13C Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for ANKRD13C Gene
Function for ANKRD13C Gene
Molecular function for ANKRD13C Gene
- UniProtKB/Swiss-Prot Function:
- Acts as a molecular chaperone for G protein-coupled receptors, regulating their biogenesis and exit from the ER.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005102 | receptor binding | IPI | 20959461 |
Phenotypes for ANKRD13C Gene
- GenomeRNAi human phenotypes for ANKRD13C:
Animal Model Products
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-
-
ViGene Biosciences lentiviral particle packaged cDNA for ANKRD13C gene
-
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CRISPR Products
-
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-
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miRNA for ANKRD13C Gene
- miRTarBase miRNAs that target ANKRD13C
miRNA Products
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Inhibitory RNA Products
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for ANKRD13C
-
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-
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-
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Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ANKRD13C Gene
Localization for ANKRD13C Gene
Subcellular locations from UniProtKB/Swiss-Prot for ANKRD13C Gene
- Endoplasmic reticulum membrane. Note=Associated with the cytosolic side.
| Compartment | Confidence |
|---|---|
| endoplasmic reticulum | 5 |
| cytosol | 3 |
| nucleus | 2 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005783 | colocalizes_with endoplasmic reticulum | IDA,IEA | 20959461 |
| GO:0005789 | endoplasmic reticulum membrane | IEA | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0048471 | perinuclear region of cytoplasm | IDA | 20959461 |
Pathways & Interactions for ANKRD13C Gene
No Data Available
Interacting Proteins for ANKRD13C Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006621 | protein retention in ER lumen | IMP | 20959461 |
| GO:0010869 | regulation of receptor biosynthetic process | IDA | 20959461 |
| GO:2000209 | regulation of anoikis | IDA | 20959461 |
No data available for Pathways by source and SIGNOR curated interactions for ANKRD13C Gene
Transcripts for ANKRD13C Gene
mRNA/cDNA for ANKRD13C Gene
- (8) REFSEQ mRNAs :
- (4) Additional mRNA sequences :
- (143) Selected AceView cDNA sequences:
- (5) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for ANKRD13C Gene
CRISPR Products
-
OriGene CRISPR knockouts for ANKRD13C
-
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- GenScript: Design CRISPR guide RNA sequences for ANKRD13C
miRNA Products
- Search ViGene Biosciences for ANKRD13C
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for ANKRD13C
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ViGene Biosciences ready-to-package AAV shRNAs for ANKRD13C gene
Clone Products
-
OriGene ORF clones in human for ANKRD13C
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- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for ANKRD13C
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ANKRD13C
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b | · | 13c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||
| SP3: | - | ||||||||||||||||||||||||||||||||
| SP4: | - | - |
Expression for ANKRD13C Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
This gene is overexpressed in Bone marrow mesenchymal stem cell (58.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ANKRD13C Gene
NURSA nuclear receptor signaling pathways regulating expression of ANKRD13C Gene:
ANKRD13CSOURCE GeneReport for Unigene cluster for ANKRD13C Gene:
Hs.744989Evidence on tissue expression from TISSUES for ANKRD13C Gene
- Intestine(4.2)
- Kidney(4.2)
- Eye(4.1)
- Nervous system(3.1)
Primer Products
-
OriGene qPCR primer pairs and template standards for ANKRD13C
-
OriGene qPCR primer pairs for ANKRD13C
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ANKRD13C Gene
Orthologs for ANKRD13C Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ANKRD13C 34 35 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | ANKRD13C 35 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | ANKRD13C 35 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | ANKRD13C 34 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Ankrd13c 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Ankrd13c 34 16 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | ANKRD13C 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | ANKRD13C 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | ANKRD13C 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | ankrd13c 34 |
|
||
| Str.8944 34 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | MGC53218 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | ankrd13c 34 35 |
|
||
| wufc57c01 34 |
|
||||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.10323 34 |
|
||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP009954 34 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | CG5742 34 35 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | C01F1.6 34 35 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.6516 35 |
|
OneToOne |
- Species where no ortholog for ANKRD13C was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for ANKRD13C Gene
Variants for ANKRD13C Gene
| SNP ID | Clin | Chr 01 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000006114 | -- | 70,321,041(+) | CTGGG(G/T)TTACT | intron-variant | |
| rs1000017914 | -- | 70,268,178(+) | CCCGC(C/T)CCCAC | intron-variant | |
| rs1000046756 | -- | 70,287,894(+) | GCATG(C/T)GTGTA | intron-variant | |
| rs1000060852 | -- | 70,280,998(+) | CTAAG(A/G)AGAAA | intron-variant | |
| rs1000068370 | -- | 70,350,731(+) | AGAAA(-/TACT)TACAA | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv1997734 | CNV | deletion | 18987734 |
| esv2555384 | CNV | deletion | 19546169 |
| esv2657438 | CNV | deletion | 23128226 |
| esv2749597 | CNV | deletion | 23290073 |
| esv3563704 | CNV | deletion | 23714750 |
| esv3586352 | CNV | loss | 21293372 |
| esv3586353 | CNV | loss | 21293372 |
| esv4055 | CNV | loss | 18987735 |
| nsv1012563 | CNV | gain | 25217958 |
| nsv1014292 | CNV | gain | 25217958 |
| nsv473705 | CNV | novel sequence insertion | 20440878 |
| nsv830137 | CNV | loss | 17160897 |
Residual Variation Intolerance Score:
19.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.67;
14.29% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for ANKRD13C Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- ANKRD13C
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANKRD13C Gene
Disorders for ANKRD13C Gene
Relevant External Links for ANKRD13C
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- ANKRD13C
No disorders were found for ANKRD13C Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANKRD13C Gene
Publications for ANKRD13C Gene
- Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 2 3 4 64
- ANKRD13C acts as a molecular Chaperone for G protein-coupled receptors. (PMID: 20959461) Parent A. … Parent J.L. (J. Biol. Chem. 2010) 3 4 64
- The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
Products for ANKRD13C Gene
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- VectorBuilder custom plasmid, inducible vectors for ANKRD13C
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ANKRD13C
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for ANKRD13C Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
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- (88) miRTarBase
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- (92) Vector BioLabs
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- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
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- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
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- (109) TreeFam
- (110) PathCards
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- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer