ANKRD13B Gene
protein-coding GIFtS: 46
GCID: GC17P027916
|
|
ankyrin repeat domain 13B
| |
Aliases
for ANKRD13B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Ankyrin Repeat Domain 13B1 2 | | FLJ255551 | | Ankyrin Repeat Domain-Containing Protein 13B2 |
Export aliases for ANKRD13B gene to outside databasesPrevious GC identifers: GC17P024945 GC17P024129 |
Summaries
for ANKRD13B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for ANKRD13B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010799.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ANKRD13B gene promoter:
Spz1 p53 HTF NRSF form 1 NRSF form 2 c-Ets-1 HEN1 Nkx6-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for ANKRD13B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ANKRD13B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q11.2 Ensembl cytogenetic band: 17q11.2 HGNC cytogenetic band: 17q11.2ANKRD13B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17P027916: view genomic region
(about GC identifiers)
Start:
|
27,916,787 bp from pter |
End:
|
27,941,779 bp from pter |
Size:
|
24,993 bases |
Orientation:
|
plus strand |
|
Proteins
for ANKRD13B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: AN13B_HUMAN, Q86YJ7 (See
protein sequence)Recommended Name: Ankyrin repeat domain-containing protein 13B Size: 626 amino acids; 70205 Da
Secondary accessions: Q8N7S9Alternative splicing: 2 isoforms: Q86YJ7-1 Q86YJ7-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for ANKRD13B: NX_Q86YJ7
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q86YJ7
ANKRD13B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_689558.4
ENSEMBL proteins: ENSP00000467078 ENSP00000378328 ENSP00000431958 ENSP00000465708
Human Recombinant Protein Products:
ANKRD13B Antibody Products:
Assay Products for ANKRD13B: |
Protein
Domains /
Families
for ANKRD13B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ANKRD13B for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q86YJ7ProtoNet protein and cluster: Q86YJ7 2 Blocks protein families: IPB002110 Ankyrin repeat signature IPB003903 Ubiquitin interacting motif
UniProtKB/Swiss-Prot: AN13B_HUMAN, Q86YJ7Similarity: Contains 2 ANK repeatsSimilarity: Contains 3 UIM (ubiquitin-interacting motif) repeats |
Function
for ANKRD13B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ANKRD13B (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ANKRD13B
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: ANKRD13B (NM_152345) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ANKRD13B | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ANKRD13B |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANKRD13B |
1 GenomeRNAi human phenotype for ANKRD13B:
|
Pathways & Interactions
for ANKRD13B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ANKRD13B
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
4 Interacting proteins for ANKRD13B (Q86YJ72, 3 ENSP000003783284) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for ANKRD13B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ANKRD13B
Search CenterWatch for drugs/clinical trials and news about ANKRD13B / AN13B
|
Transcripts
for ANKRD13B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ANKRD13B gene: NM_152345.4 Unigene Cluster for ANKRD13B: Ankyrin repeat domain 13B Hs.662164 [show with all ESTs]Unigene Representative Sequence: NM_1523458 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000583728 ENST00000487527(uc002heh.3) ENST00000394859(uc002hei.3)
ENST00000488766(uc002hej.3) ENST00000493506 ENST00000578811 ENST00000578943
ENST00000579719
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ANKRD13B (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ANKRD13B
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ANKRD13B (NM_152345) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ANKRD13B | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ANKRD13B |
Additional cDNA sequence: AK000425.1 AK092673.1 AK098421.1 BC062597.1 13 DOTS entries: DT.99931292 DT.100036048 DT.92416034 DT.97763124 DT.120914693 DT.455002 DT.91842840 DT.97837246 DT.100774746 DT.91709297 DT.97821329 DT.100782530 DT.120914684 24/55 AceView cDNA sequences (see all 55): AK000425 BM725700 BQ050576 BC062597 BM922317 BC032554 AI370708 NM_152345 BQ068610 AK097716 AK098421 BQ933868 CR602753 AA378073 AK092673 CD243443 BQ883283 AI866586 BQ948589 BX389989 BM474025 BF836088 AI193491 BX447290
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for ANKRD13B (see all 6) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | · | 4c | · | 4d | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b | ^ | 14 |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for ANKRD13B
|
Expression
for ANKRD13B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ANKRD13B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTGCCTCGGA
About this image
See ANKRD13B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ANKRD13B
SOURCE GeneReport for Unigene cluster: Hs.662164
SABiosciences Custom PCR Arrays for ANKRD13B
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ANKRD13B
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ANKRD13B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ANKRD13B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ANKRD13B | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANKRD13B |
Orthologs
for ANKRD13B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for ANKRD13B gene from 8/23 species (see all 23) About this table
ENSEMBL Gene Tree for ANKRD13B (if available)
TreeFam Gene Tree for ANKRD13B (if available) |
Paralogs
for ANKRD13B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ANKRD13B gene
- ANKRD13D2 ANKRD13A2 ANKRD13C2
4 SIMAP similar genes for ANKRD13B using alignment to 4 protein entries: AN13B_HUMAN (see all proteins):ANKRD13D ANKRD13A ANKRD13 ANKRD13C
ANKRD13B for paralogs About GeneDecksing
|
Genomic Variants
for ANKRD13B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ANKRD13B (27916787 - 27941779 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for ANKRD13B
1 Indel: 72857 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ANKRD13B |
|
Disorders
/ Diseases
for ANKRD13B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for ANKRD13B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ANKRD13B gene integrated from 9 sources:
(articles sorted by number of sources associating them with ANKRD13B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The Ankrd 13 family of UIM-bearing proteins regulates EGF receptor endocytosis from the plasma membrane. (PubMed id 22298428)1 Tanno H....Komada M. (2012)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Hundreds of variants clustered in genomic loci and bi ological pathways affect human height. (PubMed id 20881960)1 Lango Allen H....Hirschhorn J.N. (2010)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PubMed id 16625196)2 Zody M.C.... Nusbaum C. (2006)
- A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (2005)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for ANKRD13B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ANKRD13B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ANKRD13B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ANKRD13B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ANKRD13B | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ANKRD13B gene:
Search GeneIP for patents involving ANKRD13B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ANKRD13B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ANKRD13B | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ANKRD13B | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ANKRD13B | | | OriGene Protein Over-expression Lysate for ANKRD13B | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ANKRD13B | | OriGene 3'-UTR Clone for ANKRD13B | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ANKRD13B | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ANKRD13B | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for ANKRD13B | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for ANKRD13B | | OriGene Custom Protein Services for ANKRD13B | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ANKRD13B | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ANKRD13B | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ANKRD13B | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ANKRD13B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ANKRD13B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ANKRD13B |
| |
 |  |  |  | |
| | | |  |  |  |  | | | | |
 |
 |
 |
 | | | ANKRD13B Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANKRD13B |
|  |  |  | | | | Search ThermoFisher Antibodies for ANKRD13B |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ANKRD13B |
|
|
|
|
