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Aliases for ANKRD13B Gene

Aliases for ANKRD13B Gene

  • Ankyrin Repeat Domain 13B 2 3

External Ids for ANKRD13B Gene

Summaries for ANKRD13B Gene

GeneCards Summary for ANKRD13B Gene

ANKRD13B (Ankyrin Repeat Domain 13B) is a Protein Coding gene. An important paralog of this gene is ANKRD13D.

UniProtKB/Swiss-Prot for ANKRD13B Gene

  • Ubiquitin-binding protein that specifically recognizes and binds Lys-63-linked ubiquitin. Does not bind Lys-48-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANKRD13B Gene

Genomics for ANKRD13B Gene

Genomic Location for ANKRD13B Gene

Start:
29,589,769 bp from pter
End:
29,614,761 bp from pter
Size:
24,993 bases
Orientation:
Plus strand

Genomic View for ANKRD13B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ANKRD13B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANKRD13B Gene

Regulatory Elements for ANKRD13B Gene

Proteins for ANKRD13B Gene

  • Protein details for ANKRD13B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86YJ7-AN13B_HUMAN
    Recommended name:
    Ankyrin repeat domain-containing protein 13B
    Protein Accession:
    Q86YJ7
    Secondary Accessions:
    • Q8N7S9

    Protein attributes for ANKRD13B Gene

    Size:
    626 amino acids
    Molecular mass:
    70205 Da
    Quaternary structure:
    • Interacts with EGFR (ubiquitinated); the interaction is direct and may regulate EGFR internalization.

    Alternative splice isoforms for ANKRD13B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ANKRD13B Gene

Proteomics data for ANKRD13B Gene at MOPED

Post-translational modifications for ANKRD13B Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys246

Other Protein References for ANKRD13B Gene

No data available for DME Specific Peptides for ANKRD13B Gene

Domains for ANKRD13B Gene

Gene Families for ANKRD13B Gene

HGNC:
  • ANKRD :Ankyrin repeat domain containing

UniProtKB/Swiss-Prot:

AN13B_HUMAN
Domain:
  • Contains 3 UIM (ubiquitin-interacting motif) domains.:
    • Q86YJ7
Similarity:
  • Contains 2 ANK repeats.:
    • Q86YJ7
genes like me logo Genes that share domains with ANKRD13B: view

Function for ANKRD13B Gene

Molecular function for ANKRD13B Gene

UniProtKB/Swiss-Prot Function: Ubiquitin-binding protein that specifically recognizes and binds Lys-63-linked ubiquitin. Does not bind Lys-48-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane.

Gene Ontology (GO) - Molecular Function for ANKRD13B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with ANKRD13B: view

Phenotypes for ANKRD13B Gene

GenomeRNAi human phenotypes for ANKRD13B:
genes like me logo Genes that share phenotypes with ANKRD13B: view

miRNA for ANKRD13B Gene

miRTarBase miRNAs that target ANKRD13B

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ANKRD13B Gene

Localization for ANKRD13B Gene

Subcellular locations from UniProtKB/Swiss-Prot for ANKRD13B Gene

Cell membrane. Late endosome. Early endosome. Note=Interaction with EGFR may enhance association with the cell membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ANKRD13B Gene COMPARTMENTS Subcellular localization image for ANKRD13B gene
Compartment Confidence
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for ANKRD13B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome --
GO:0005769 early endosome IEA --
GO:0005770 late endosome IEA --
GO:0005886 plasma membrane IEA --
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with ANKRD13B: view

Pathways for ANKRD13B Gene

SuperPathways for ANKRD13B Gene

No Data Available

Interacting Proteins for ANKRD13B Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000378328%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000275493%0d%0a
Selected Interacting proteins: Q86YJ7-AN13B_HUMAN ENSP00000378328 for ANKRD13B Gene via MINT STRING I2D

Gene Ontology (GO) - Biological Process for ANKRD13B Gene

None

No data available for Pathways by source for ANKRD13B Gene

Transcripts for ANKRD13B Gene

Unigene Clusters for ANKRD13B Gene

Ankyrin repeat domain 13B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ANKRD13B Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14
SP1:
SP2: - -
SP3: -
SP4:
SP5:
SP6: -

Relevant External Links for ANKRD13B Gene

GeneLoc Exon Structure for
ANKRD13B
ECgene alternative splicing isoforms for
ANKRD13B

Expression for ANKRD13B Gene

mRNA expression in normal human tissues for ANKRD13B Gene

mRNA differential expression in normal tissues according to GTEx for ANKRD13B Gene

This gene is overexpressed in Brain - Cerebellum (4.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ANKRD13B Gene

SOURCE GeneReport for Unigene cluster for ANKRD13B Gene Hs.662164

genes like me logo Genes that share expressions with ANKRD13B: view

Orthologs for ANKRD13B Gene

This gene was present in the common ancestor of animals.

Orthologs for ANKRD13B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ANKRD13B 36
  • 99.68 (n)
  • 99.68 (a)
ANKRD13B 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ANKRD13B 36
  • 92.75 (n)
  • 98.16 (a)
ANKRD13B 37
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ANKRD13B 36
  • 93.09 (n)
  • 98.49 (a)
ANKRD13B 37
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ankrd13b 36
  • 89.83 (n)
  • 97.31 (a)
Ankrd13b 16
Ankrd13b 37
  • 80 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ANKRD13B 37
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ANKRD13B 37
  • 82 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ankrd13b 36
  • 90.1 (n)
  • 97.32 (a)
chicken
(Gallus gallus)
Aves ANKRD13B 36
  • 83.24 (n)
  • 88.93 (a)
ANKRD13B 37
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ANKRD13B 37
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ankrd13b 36
  • 75.78 (n)
  • 88.12 (a)
zebrafish
(Danio rerio)
Actinopterygii ankrd13b 37
  • 70 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG15118 37
  • 43 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C18F10.7 37
  • 36 (a)
OneToMany
Species with no ortholog for ANKRD13B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ANKRD13B Gene

ENSEMBL:
Gene Tree for ANKRD13B (if available)
TreeFam:
Gene Tree for ANKRD13B (if available)

Paralogs for ANKRD13B Gene

Paralogs for ANKRD13B Gene

Selected SIMAP similar genes for ANKRD13B Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ANKRD13B: view

Variants for ANKRD13B Gene

Sequence variations from dbSNP and Humsavar for ANKRD13B Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs191315 -- 29,609,947(-) caaag(C/T)gctgg intron-variant
rs330159 -- 29,609,976(-) cctca(A/G)gtgat intron-variant
rs330160 -- 29,609,931(-) caggc(A/G)tgagc intron-variant
rs1443346 -- 29,592,507(-) GCTGG(C/T)CCTTC upstream-variant-2KB, intron-variant
rs1529421 -- 29,608,580(-) ccatt(C/G)tttca intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ANKRD13B Gene

Variant ID Type Subtype PubMed ID
nsv833409 CNV Gain 17160897
nsv521557 CNV Loss 19592680
dgv3135n71 CNV Loss 21882294
dgv3136n71 CNV Loss 21882294
nsv908038 CNV Loss 21882294
esv26830 CNV Loss 19812545
nsv827941 CNV Gain 20364138
nsv833410 CNV Loss 17160897

Relevant External Links for ANKRD13B Gene

HapMap Linkage Disequilibrium report
ANKRD13B

Disorders for ANKRD13B Gene

No disorders were found for ANKRD13B Gene.

No data available for UniProtKB/Swiss-Prot for ANKRD13B Gene

Publications for ANKRD13B Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. The Ankrd 13 family of UIM-bearing proteins regulates EGF receptor endocytosis from the plasma membrane. (PMID: 22298428) Tanno H. … Komada M. (Mol. Biol. Cell 2012) 3 4
  4. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody M.C. … Nusbaum C. (Nature 2006) 4
  5. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PMID: 22814378) Van Damme P. … Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012) 4

Products for ANKRD13B Gene

Sources for ANKRD13B Gene

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