Aliases for ANKRD13B Gene
External Ids for ANKRD13B Gene
- HGNC: 26363
- Entrez Gene: 124930
- Ensembl: ENSG00000198720
- OMIM: 615124
- UniProtKB: Q86YJ7
Previous GeneCards Identifiers for ANKRD13B Gene
- GC17P024945
- GC17P027916
- GC17P024129
Summaries for ANKRD13B Gene
GeneCards Summary for ANKRD13B Gene
ANKRD13B (Ankyrin Repeat Domain 13B) is a Protein Coding gene. An important paralog of this gene is ANKRD13D.
UniProtKB/Swiss-Prot for ANKRD13B Gene
-
Ubiquitin-binding protein that specifically recognizes and binds Lys-63-linked ubiquitin. Does not bind Lys-48-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane.
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANKRD13B Gene
Genomics for ANKRD13B Gene
Regulatory Elements for ANKRD13B Gene
Enhancers for ANKRD13B Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around ANKRD13B on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the ANKRD13B gene promoter:
Regulatory Element Products
Genomic Location for ANKRD13B Gene
- Chromosome:
- 17
- Start:
- 29,589,769 bp from pter
- End:
- 29,614,761 bp from pter
- Size:
- 24,993 bases
- Orientation:
- Plus strand
Genomic View for ANKRD13B Gene
Genes around ANKRD13B on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17q11.2 by Ensembl
- 17q11.2 by Entrez Gene
- 17q11.2 by HGNC
ANKRD13B Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ANKRD13B Gene
Proteins for ANKRD13B Gene
-
Protein details for ANKRD13B Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q86YJ7-AN13B_HUMAN
- Recommended name:
- Ankyrin repeat domain-containing protein 13B
- Protein Accession:
- Q86YJ7
- Q8N7S9
Protein attributes for ANKRD13B Gene
- Size:
- 626 amino acids
- Molecular mass:
- 70205 Da
- Quaternary structure:
-
- Interacts with EGFR (ubiquitinated); the interaction is direct and may regulate EGFR internalization.
Protein Expression for ANKRD13B Gene
Post-translational modifications for ANKRD13B Gene
Other Protein References for ANKRD13B Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for ANKRD13B
- Novus Biologicals Antibodies for ANKRD13B
- Invitrogen Antibodies for ANKRD13B
- GeneTex ANKRD13B antibody for ANKRD13B
Protein Products
-
OriGene Purified Proteins for ANKRD13B
- Search Origene for MassSpec and Protein Over-expression Lysates for ANKRD13B
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- Search GeneTex for Proteins for ANKRD13B
Assay Products
No data available for DME Specific Peptides for ANKRD13B Gene
Domains & Families for ANKRD13B Gene
Gene Families for ANKRD13B Gene
Protein Domains for ANKRD13B Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for ANKRD13B Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for ANKRD13B Gene
Function for ANKRD13B Gene
Molecular function for ANKRD13B Gene
- UniProtKB/Swiss-Prot Function:
- Ubiquitin-binding protein that specifically recognizes and binds Lys-63-linked ubiquitin. Does not bind Lys-48-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane.
Phenotypes for ANKRD13B Gene
- GenomeRNAi human phenotypes for ANKRD13B:
-
- Increased vaccinia virus (VACV) infection
- Mildly decreased CFP-tsO45G cell surface transport
- Dynamic nuclei (hole, folded or small irregular)
- Increased transferrin (TF) endocytosis
- Negative genetic interaction between PTTG1-/- and PTTG1+/+
- Increased cell death HMECs cells
- Weakly decreased NFAT1-GFP nuclear translocation
Animal Model Products
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- Cyagen custom Knockout/knockin (KOKI) mouse models for ANKRD13B
-
-
ViGene Biosciences lentiviral particle packaged cDNA for ANKRD13B gene
-
ViGene Biosciences ready-to-package AAV shRNAs for ANKRD13B gene
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CRISPR Products
-
OriGene CRISPR knockouts for ANKRD13B
-
Santa Cruz Biotechnology (SCBT) CRISPR for ANKRD13B
- GenScript: Design CRISPR guide RNA sequences for ANKRD13B
miRNA for ANKRD13B Gene
- miRTarBase miRNAs that target ANKRD13B
-
- hsa-mir-373-3p (MIRT003948)
- hsa-mir-505-3p (MIRT040994)
- hsa-mir-15a-5p (MIRT145377)
- hsa-mir-16-5p (MIRT145378)
- hsa-mir-92a-2-5p (MIRT145379)
- hsa-mir-15b-5p (MIRT145382)
- hsa-mir-195-5p (MIRT145386)
- hsa-mir-608 (MIRT145392)
- hsa-mir-1275 (MIRT145404)
- hsa-mir-4447 (MIRT145411)
- hsa-mir-4472 (MIRT145413)
- hsa-mir-4651 (MIRT145419)
- hsa-mir-4665-5p (MIRT145421)
- hsa-mir-6756-5p (MIRT145433)
- hsa-mir-6766-5p (MIRT145434)
- hsa-mir-6858-5p (MIRT494778)
- hsa-mir-6779-5p (MIRT494779)
- hsa-mir-6089 (MIRT494780)
- hsa-mir-5010-5p (MIRT494781)
- hsa-mir-4525 (MIRT494782)
- hsa-mir-7111-5p (MIRT494783)
- hsa-mir-6870-5p (MIRT494784)
- hsa-mir-5698 (MIRT494785)
- hsa-mir-4723-5p (MIRT494786)
- hsa-mir-625-5p (MIRT494787)
- hsa-mir-185-3p (MIRT494788)
- hsa-mir-6825-5p (MIRT494789)
- hsa-mir-6883-5p (MIRT494790)
- hsa-mir-4728-5p (MIRT494791)
- hsa-mir-6785-5p (MIRT494792)
- hsa-mir-149-3p (MIRT494793)
- hsa-mir-423-5p (MIRT494794)
- hsa-mir-3184-5p (MIRT494795)
- hsa-mir-6813-5p (MIRT494796)
- hsa-mir-6085 (MIRT494797)
- hsa-mir-203a-3p (MIRT494798)
- hsa-mir-762 (MIRT570741)
- hsa-mir-5001-5p (MIRT570742)
- hsa-mir-4498 (MIRT570743)
- hsa-mir-4492 (MIRT570744)
miRNA Products
- Search ViGene Biosciences for ANKRD13B
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for ANKRD13B
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-
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- VectorBuilder custom plasmid, inducible vectors for ANKRD13B
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ANKRD13B
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for ANKRD13B
-
ViGene Biosciences adenoviral particle packaged cDNA for ANKRD13B gene
-
ViGene Biosciences lentiviral particle packaged cDNA for ANKRD13B gene
-
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Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ANKRD13B Gene
Localization for ANKRD13B Gene
Subcellular locations from UniProtKB/Swiss-Prot for ANKRD13B Gene
- Cell membrane. Late endosome. Early endosome. Note=Interaction with EGFR may enhance association with the cell membrane.
| Compartment | Confidence |
|---|---|
| plasma membrane | 3 |
| nucleus | 3 |
| endosome | 3 |
| cytosol | 2 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IBA | -- |
| GO:0005768 | endosome | IEA | -- |
| GO:0005769 | early endosome | IEA | -- |
| GO:0005770 | late endosome | IEA | -- |
| GO:0005886 | plasma membrane | IEA | -- |
Pathways & Interactions for ANKRD13B Gene
No Data Available
No data available for Pathways by source and SIGNOR curated interactions for ANKRD13B Gene
Transcripts for ANKRD13B Gene
mRNA/cDNA for ANKRD13B Gene
- (8) REFSEQ mRNAs :
- (4) Additional mRNA sequences :
- (55) Selected AceView cDNA sequences:
- (9) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for ANKRD13B Gene
CRISPR Products
-
OriGene CRISPR knockouts for ANKRD13B
-
Santa Cruz Biotechnology (SCBT) CRISPR for ANKRD13B
- GenScript: Design CRISPR guide RNA sequences for ANKRD13B
miRNA Products
- Search ViGene Biosciences for ANKRD13B
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for ANKRD13B
- Browse OriGene Inhibitory RNA Products For ANKRD13B
-
ViGene Biosciences ready-to-package AAV shRNAs for ANKRD13B gene
Clone Products
-
OriGene ORF clones in human for ANKRD13B
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for ANKRD13B
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ANKRD13B
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | · | 4c | · | 4d | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b | ^ | 14 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP3: | - | ||||||||||||||||||||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||||||||||||||||||||
| SP5: | |||||||||||||||||||||||||||||||||||||||||||
| SP6: | - |
Expression for ANKRD13B Gene
mRNA differential expression in normal tissues according to GTEx for ANKRD13B Gene
This gene is overexpressed in Brain - Cerebellum (x4.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ANKRD13B Gene
NURSA nuclear receptor signaling pathways regulating expression of ANKRD13B Gene:
ANKRD13BSOURCE GeneReport for Unigene cluster for ANKRD13B Gene:
Hs.662164Evidence on tissue expression from TISSUES for ANKRD13B Gene
- Skin(4.1)
- Nervous system(2.2)
Primer Products
-
OriGene qPCR primer pairs for ANKRD13B
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ANKRD13B Gene
Orthologs for ANKRD13B Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ANKRD13B 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | ANKRD13B 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | ANKRD13B 34 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Ankrd13b 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | ANKRD13B 35 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Ankrd13b 34 16 35 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | ANKRD13B 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | ANKRD13B 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | ANKRD13B 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | ankrd13b 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | ankrd13b 35 |
|
OneToOne | |
| fruit fly (Drosophila melanogaster) |
Insecta | CG15118 35 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | C18F10.7 35 |
|
OneToMany |
- Species where no ortholog for ANKRD13B was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for ANKRD13B Gene
(4) SIMAP similar genes for ANKRD13B Gene using alignment to 4 proteins:
Variants for ANKRD13B Gene
| SNP ID | Clin | Chr 17 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000108303 | -- | 29,614,083(+) | GTCTA(-/G)GGCCC | nc-transcript-variant, utr-variant-3-prime | |
| rs1000196818 | -- | 29,591,122(+) | TGAGA(C/T)GGGAG | intron-variant, upstream-variant-2KB | |
| rs1000390000 | -- | 29,611,391(+) | ACAGA(A/G)GCCCT | intron-variant | |
| rs1000467550 | -- | 29,599,485(+) | TTTGG(A/G)GGCAG | intron-variant | |
| rs1000622021 | -- | 29,605,472(+) | CATAT(A/G)TATAT | intron-variant |
Residual Variation Intolerance Score:
10.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.08;
22.01% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for ANKRD13B Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- ANKRD13B
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANKRD13B Gene
Disorders for ANKRD13B Gene
Relevant External Links for ANKRD13B
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- ANKRD13B
No disorders were found for ANKRD13B Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANKRD13B Gene
Publications for ANKRD13B Gene
- The Ankrd 13 family of UIM-bearing proteins regulates EGF receptor endocytosis from the plasma membrane. (PMID: 22298428) Tanno H. … Komada M. (Mol. Biol. Cell 2012) 3 4 64
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
- The Ankrd13 Family of Ubiquitin-interacting Motif-bearing Proteins Regulates Valosin-containing Protein/p97 Protein-mediated Lysosomal Trafficking of Caveolin 1. (PMID: 26797118) Burana D. … Komada M. (J. Biol. Chem. 2016) 3 64
- The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
Products for ANKRD13B Gene
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- Horizon Cell Lines for ANKRD13B
- Cyagen custom Knockout/knockin (KOKI) mouse models for ANKRD13B
- VectorBuilder custom plasmid, inducible vectors for ANKRD13B
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ANKRD13B
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for ANKRD13B Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
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- (92) Vector BioLabs
- (93) ESI-BIO
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- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
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- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
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- (141) ENCODE
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- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer