ANKRD13A Gene
protein-coding GIFtS : 46
GCID: GC12 P110437
ankyrin repeat domain 13A (Previous name: ankyrin repeat domain 13 ) (Previous symbol: ANKRD13 )
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Aliasesfor ANKRD13A gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Ankyrin Repeat Domain 13A 1 2 Ankyrin Repeat Domain-Containing Protein 13A2 ANKRD131 2 3 NY-REN-25 Antigen2 NY-REN-251 2 Protein KE033 Ankyrin Repeat Domain 131
Export aliases for ANKRD13A gene to outside databases Previous GC identifers: GC12P108921 GC12P107452
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Summariesfor ANKRD13A gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section --
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Genomic Viewsfor ANKRD13A gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000012.11 NC_018923.1 NT_009775.17 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the ANKRD13A gene promoter: E2F-4 E2F-3a E2F-5 Elk-1 AP-1 E2F-2 POU2F1 E2F E2F-1 En-1 Other transcription factors Search SABiosciences Chromatin IP Primers for ANKRD13A Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat ANKRD13A
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 12q24.11 Ensembl cytogenetic band: 12q24.11 HGNC cytogenetic band: 12q24.12 ANKRD13A Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 12 GeneLoc Exon Structure
GeneLoc location for GC12P110437: view genomic region
(about GC identifiers )
Start:
110,436,991 bp from pter
End:
110,477,568 bp from pter
Size:
40,578 bases
Orientation:
plus strand
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Proteinsfor ANKRD13A gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: AN13A_HUMAN, Q8IZ07 (See
protein sequence )Recommended Name: Ankyrin repeat domain-containing protein 13A Size : 590 amino acids; 67619 Da
Sequence caution : Sequence=AAC17109.1; Type=Frameshift; Positions=343, 348;
Secondary accessions : O60736Explore the universe of human proteins at neXtProt for ANKRD13A: NX_Q8IZ07 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q8IZ07 ANKRD13A Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_149112.1 ENSEMBL proteins: ENSP00000261739 ENSP00000449781 ENSP00000449085 ENSP00000449220 ENSP00000448470 ENSP00000447288 ENSP00000447110 Human Recombinant Protein Products: ANKRD13A Antibody Products: Assay Products for ANKRD13A:
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Protein
Domains / Familiesfor ANKRD13A gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
ANKRD13A for domains About GeneDecksing 4 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q8IZ07 ProtoNet protein and cluster: Q8IZ07
2 Blocks protein families : IPB002110 Ankyrin repeat signature IPB003903 Ubiquitin interacting motif UniProtKB/Swiss-Prot: AN13A_HUMAN, Q8IZ07 Similarity : Contains 2 ANK repeatsSimilarity : Contains 3 UIM (ubiquitin-interacting motif) repeats
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Functionfor ANKRD13A gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for ANKRD13A (see all 4 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for ANKRD13AOriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: ANKRD13A (NM_033121 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ANKRD13A Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat ANKRD13A
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANKRD13A
Animal Models: 2 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Ankrd13a) :
ANKRD13A for phenotypes About GeneDecksing
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Pathways & Interactionsfor ANKRD13A gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ANKRD13A STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)5/6 Interacting proteins for ANKRD13A (Q8IZ07 2 , 3 ENSP00000261739 4 ) via UniProtKB, MINT, STRING , and/or I2D (see all 6 )About this table
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Drugs & Compoundsfor ANKRD13A gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for ANKRD13A Search CenterWatch for drugs/clinical trials and news about ANKRD13A / AN13A
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Transcriptsfor ANKRD13A gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for ANKRD13A gene: NM_033121.1 Unigene Cluster for ANKRD13A:
Ankyrin repeat domain 13A Hs.528703 [show with all ESTs ] Unigene Representative Sequence: NM_033121 10 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000553025 (uc009zvl.1 ) ENST00000550404 (uc009zvm.2 ) ENST00000261739 (uc001tpx.3 uc010sxw.2 uc001tpy.3 uc001tqa.3 )ENST00000547639 ENST00000546476 ENST00000547419 ENST00000553251 (uc001tpz.3 )ENST00000549826 ENST00000551491 ENST00000553246 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for ANKRD13A (see all 4 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for ANKRD13AOriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: ANKRD13A (NM_033121 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ANKRD13A Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat ANKRD13A
Additional cDNA sequence: AF064604.1 AF155103.1 AK022658.1 AK095130.1 AK293232.1 AK302535.1 AK308923.1 AY364251.1 BC032833.2
18 DOTS entries : DT.100780270 DT.117869
DT.95300633 DT.92438549 DT.100780267 DT.95300628 DT.407517 DT.121186456 DT.95284707 DT.95300636 DT.100642475 DT.100780268 DT.100666602 DT.121186460 DT.121186503 DT.75120823 DT.91996504 DT.92438552 24/278 AceView cDNA sequences (see all 278 ):
AA442320 AA992014 NM_033121 CD109650 AW069120 AI457813 CD724151 AW958869 BM798794 AL120745 W46423 AA639629 CB122859 AK130522 AA371369 CD242698 AA358054 BQ223645 AA483310 BM970069 BX098259 BF447132 AA722582 AA830102 GeneLoc Exon Structure 5/8 Alternative Splicing Database (ASD) splice patterns (SP) for ANKRD13A (see all 8 ) About this scheme ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b · 11c ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b · 16c · 16d SP1 :                       -   -           -   -     -             SP2 :                                                     SP3 :                                                     SP4 :                                     -     -             SP5 :                                     -   -   -            
ECgene alternative splicing isoforms for ANKRD13A
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Expression for ANKRD13A gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section ANKRD13A expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: AGGCCAGTAT
About this image ANKRD13A expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table See ANKRD13A Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for ANKRD13A SOURCE GeneReport for Unigene cluster: Hs.528703 SABiosciences Custom PCR Arrays for ANKRD13A Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for ANKRD13ABrowse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat ANKRD13A QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat ANKRD13A QIAGEN QuantiFast Probe-based Assays in human , mouse , rat ANKRD13A In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANKRD13A
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Orthologsfor ANKRD13A gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of eukaryotes.
Orthologs for ANKRD13A gene from 8/23 species (see all 23 ) About this table
ENSEMBL Gene Tree for ANKRD13A (if available)TreeFam Gene Tree for ANKRD13A (if available)
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Paralogsfor ANKRD13A gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for ANKRD13A gene ANKRD13B 2 ANKRD13D 2 ANKRD13C 2 5 SIMAP similar genes for ANKRD13A using alignment to 7 protein entries: AN13A_HUMAN (see all proteins ):ANKRD13 ANKRD13D ANKRD13B ANKRD13C NRARP
ANKRD13A for paralogs About GeneDecksing
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Genomic Variantsfor ANKRD13A gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 12 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for ANKRD13A (110436991 - 110477568 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for ANKRD13A: --
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing ANKRD13A
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Disorders
/ Diseasesfor ANKRD13A gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
ANKRD13A for disorders About GeneDecksing 2 diseases for ANKRD13A : About MalaCards renal cell carcinoma carcinoma Export disorders for ANKRD13A gene to outside databases
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Publicationsfor ANKRD13A gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for ANKRD13A gene, integrated from 9 sources (see all 18 ): (articles sorted by number of sources associating them with ANKRD13A) Utopia : connect your pdf to the dynamic world of online information
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) Antigens recognized by autologous antibody in patients with renal- cell carcinoma. (PubMed id 10508479) 1 , 3 Scanlan M.J....Old L.J. (1999) The Ankrd 13 family of UIM-bearing proteins regulates EGF receptor endocytosis from the plasma membrane. (PubMed id 22298428) 1 Tanno H....Komada M. (2012) Proteome-wide identification of ubiquitylation sites b y conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931) 1 Oshikawa K....Nakayama K.I. (2012) Global landscape of HIV-human protein complexes. (PubMed id 22190034) 1 Jager S....Krogan N.J. (2012) Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724) 1 Udeshi N.D....Carr S.A. (2012) Mapping a dynamic innate immunity protein interaction network regulating type I interferon production. (PubMed id 21903422) 1 Li S....Dorf M.E. (2011) Initial characterization of the human central proteome. (PubMed id 21269460) 2 Burkard T.R.... Colinge J. (2011) A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473) 1 Wagner S.A....Choudhary C. (2011) Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983) 1 Kim W....Gygi S.P. (2011)
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External Searches for ANKRD13A gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing ANKRD13A gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing ANKRD13A gene
(According to HUGE )
About This Section --
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Specialized Databases showing ANKRD13A gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for ANKRD13A Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for ANKRD13A gene: Search GeneIP for patents involving ANKRD13A GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor ANKRD13A gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for ANKRD13A OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for ANKRD13A OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for ANKRD13A OriGene Protein Over-expression Lysate for ANKRD13A Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for ANKRD13A OriGene 3'-UTR Clone for ANKRD13A OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for ANKRD13A OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for ANKRD13A Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for ANKRD13A OriGene Custom Protein Services for ANKRD13A OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ANKRD13A QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing ANKRD13A QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat ANKRD13A QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat ANKRD13A QIAGEN QuantiFast Probe-based Assays in human , mouse , rat ANKRD13A QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat ANKRD13A
ANKRD13A Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANKRD13A
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat ANKRD13A
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