ANKRD12 Gene
protein-coding GIFtS: 49
GCID: GC18P009126
|
|
ankyrin repeat domain 12
| |
Aliases
for ANKRD12 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Ankyrin Repeat Domain 121 2 | | ANCO-22 | | KIAA08741 3 5 | | Nbla001442 | | GAC-11 2 | | Ankyrin Repeat Domain-Containing Protein 122 | | Ankyrin Repeat-Containing Cofactor 22 3 | | ANCO23 | | ANCO12 5 | | GAC-1 Protein3 | | FLJ200531 | | |
Export aliases for ANKRD12 gene to outside databasesPrevious GC identifer: GC18P009172 |
Summaries
for ANKRD12 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for ANKRD12:
This gene encodes a member of the ankyrin repeats-containing cofactor family. These proteins may inhibit thetranscriptional activity of nuclear receptors through the recruitment of histone deacetylases. The encoded proteininteracts with p160 coactivators and also represses transcription mediated by the coactivator alteration/deficiency inactivation 3 (ADA3). Alternatively spliced transcript variants encoding multiple isoforms have been observed for thisgene. (provided by RefSeq, Feb 2011)
UniProtKB/Swiss-Prot: ANR12_HUMAN, Q6UB98Function: May recruit HDACs to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependenttransactivation
|
Genomic Views
for ANKRD12 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000018.9 NC_018929.1 NT_010859.14
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ANKRD12 gene promoter:
Oct-B1 Pbx1a AML1a XBP-1 Roaz N-Myc HEN1 IRF-2 COMP1 c-Myb
Other transcription factors
Search SABiosciences Chromatin IP Primers for ANKRD12
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ANKRD12 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 18p11.22 Ensembl cytogenetic band: 18p11.22 HGNC cytogenetic band: 18p11.22ANKRD12 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 18 GeneLoc Exon Structure GeneLoc location for GC18P009126: view genomic region
(about GC identifiers)
Start:
|
9,136,226 bp from pter |
End:
|
9,285,206 bp from pter |
Size:
|
148,981 bases |
Orientation:
|
plus strand |
|
Proteins
for ANKRD12 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ANR12_HUMAN, Q6UB98 (See
protein sequence)Recommended Name: Ankyrin repeat domain-containing protein 12 Size: 2062 amino acids; 235652 Da
Subunit: Interacts with the PAS region of the p160 coactivators
Subcellular location: Nucleus
Sequence caution: Sequence=BAB15014.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-Asequence;
Secondary accessions: O94951 Q658K1 Q6QMF7 Q9H231 Q9H784Alternative splicing: 2 isoforms: Q6UB98-1 Q6UB98-2 Explore the universe of human proteins at neXtProt for ANKRD12: NX_Q6UB98
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6UB98
ANKRD12 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001077094.1 NP_001190985.1 NP_056023.3
ENSEMBL proteins: ENSP00000464422 ENSP00000262126 ENSP00000462312 ENSP00000462659 ENSP00000382897 ENSP00000441510 ENSP00000352073 ENSP00000372932
Human Recombinant Protein Products for ANKRD12:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
ANKRD12 for ontologies About GeneDecksing
ANKRD12 Antibody Products:
Assay Products for ANKRD12: |
Protein
Domains /
Families
for ANKRD12 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ANKRD12 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q6UB98ProtoNet protein and cluster: Q6UB98 1 Blocks protein family: IPB002110 Ankyrin repeat signature
UniProtKB/Swiss-Prot: ANR12_HUMAN, Q6UB98Similarity: Contains 3 ANK repeats |
Function
for ANKRD12 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: ANR12_HUMAN, Q6UB98Function: May recruit HDACs to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependenttransactivationPhenotypes:
2 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Ankrd12):
ANKRD12 for phenotypes About GeneDecksing
Animal Models:
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ANKRD12 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANKRD12 |
|
Pathways & Interactions
for ANKRD12 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ANKRD12
STRING Interaction
Network Preview (showing 5 interactants - click image to see 6)
5/10 Interacting proteins for ANKRD12 (Q6UB982, 3 ENSP000002621264) via UniProtKB, MINT, STRING, and/or I2D (see all 10)About this table
|
Drugs & Compounds
for ANKRD12 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ANKRD12
Search CenterWatch for drugs/clinical trials and news about ANKRD12 / ANR12
|
Transcripts
for ANKRD12 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ANKRD12 gene (3 alternative transcripts): NM_001083625.2 NM_001204056.1 NM_015208.4 Unigene Cluster for ANKRD12: Ankyrin repeat domain 12 Hs.464585 [show with all ESTs]Unigene Representative Sequence: NM_00120405610 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000585234 ENST00000262126(uc010dkx.1) ENST00000577992 ENST00000540578(uc010wzn.2)
ENST00000581635 ENST00000400020 ENST00000581758 ENST00000546007 ENST00000359158
ENST00000383440(uc002knv.3 uc002knw.3 uc002knx.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ANKRD12 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ANKRD12 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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Additional cDNA sequence: AB020681.1 AB073645.1 AB075493.1 AF147338.1 AF317425.1 AK000060.1 AK021430.1 AK024808.1 AK092124.1 AL834204.1 AY373757.1 AY533564.2 BC057225.1 BC070234.1 X80821.1 14 DOTS entries: DT.312978 DT.91826652 DT.97791722 DT.99996217 DT.95363433 DT.101982605 DT.95195828 DT.121083157 DT.65285499 DT.100736761 DT.92430685 DT.100787092 DT.100787097 DT.92430686 24/244 AceView cDNA sequences (see all 244): AI224967 BX404809 AW008165 NM_015208 BX424304 AI768760 AI744511 BG260338 CA440627 BE857548 BE777924 BM806884 AI633282 AL834204 BU683551 BE674087 BE219672 AI470630 AX747365 AW515935 T58198 AF147338 AU116947 AY373757
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for ANKRD12 About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for ANKRD12
|
Expression
for ANKRD12 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ANKRD12 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See ANKRD12 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ANKRD12
SOURCE GeneReport for Unigene cluster: Hs.464585
SABiosciences Custom PCR Arrays for ANKRD12
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ANKRD12
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANKRD12 |
Orthologs
for ANKRD12 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for ANKRD12 gene from 5/16 species (see all 16) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
ANKRD121 |
ankyrin repeat domain 12 |
73.24(n)
69.9(a) |
|
425900 XM_423591.3 XP_423591.3 |
lizard
(Anolis carolinensis) |
Reptilia |
ANKRD126 |
-- |
64(a) |
1 ↔ 1 |
GL343319.1(531069-568998) |
African clawed frog
(Xenopus laevis) |
Amphibia |
480123572 |
-- |
75.1(n) |
|
48012357 |
zebrafish
(Danio rerio) |
Actinopterygii |
wufi16c022 |
Transcribed sequence with moderate similarity to protein more |
77(n) |
|
CA975594.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG109846 |
-- |
21(a) |
1 → many |
3L(12743219-12746502) |
ENSEMBL Gene Tree for ANKRD12 (if available)
TreeFam Gene Tree for ANKRD12 (if available) |
Paralogs
for ANKRD12 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ANKRD12 gene
- ANKRD112 BARD12 TONSL2 ANKRD322 ANKRD312
18/22 SIMAP similar genes for ANKRD12 using alignment to 8 protein entries: ANR12_HUMAN (see all proteins)
(see all similar genes):ANKRD11 PPP1R12A PPP1R27 BARD1 CASKIN2 KIDINS220
GABPB1 PPP1R12C ANK2 ANKRD44 ANKRD49 IkBa
RAI14 ANKRD54 ANKRD65 TANC2 ANKRD6 KRIT1
ANKRD12 for paralogs About GeneDecksing
|
Genomic Variants
for ANKRD12 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 18 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ANKRD12 (9136226 - 9285206 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 8 variations for ANKRD12
2 CNVs: 67299 88709
6 Indels: 11919 11918 61597 42910 50069 11917 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ANKRD12 |
|
Disorders
/ Diseases
for ANKRD12 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 ANKRD12 for disorders About MalaCards
ANKRD12 for disorders About GeneDecksing
OMIM gene information: 610616
OMIM disorders: --
Human Genome Epidemiology (HuGE) Navigator: ANKRD12 (1 document)
Export disorders for ANKRD12 gene to outside databases
|
Publications
for ANKRD12 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ANKRD12 gene, integrated from 9 sources (see all 14):
(articles sorted by number of sources associating them with ANKRD12) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10048485)1, 2, 3 Nagase T....Ohara O. (1998)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Identification of a novel family of ankyrin repeats-containing cofactors for p160 nuclear receptor coactivators. (PubMed id 15184363)1, 2 Zhang A....Chen J.D. (2004)
- Ankyrin repeats-containing cofactors interact with ADA3 and modulate its co-activator function. (PubMed id 18377363)1, 9 Li C.W....Chen J.D. (2008)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)
- Phosphoproteome of resting human platelets. (PubMed id 18088087)2 Zahedi R.P.... Sickmann A. (2008)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
|
External Searches for ANKRD12 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ANKRD12 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ANKRD12 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing ANKRD12 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ANKRD12 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ANKRD12 gene:
Search GeneIP for patents involving ANKRD12
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ANKRD12 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
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