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Aliases for ANKRD12 Gene

Aliases for ANKRD12 Gene

  • Ankyrin Repeat Domain 12 2 3
  • Ankyrin Repeat-Containing Cofactor 2 3 4
  • KIAA0874 4 6
  • ANCO1 3 6
  • Ankyrin Repeat Domain-Containing Protein 12 3
  • GAC-1 Protein 4
  • Nbla00144 3
  • ANCO-2 3
  • GAC-1 3
  • ANCO2 4

External Ids for ANKRD12 Gene

Summaries for ANKRD12 Gene

Entrez Gene Summary for ANKRD12 Gene

  • This gene encodes a member of the ankyrin repeats-containing cofactor family. These proteins may inhibit the transcriptional activity of nuclear receptors through the recruitment of histone deacetylases. The encoded protein interacts with p160 coactivators and also represses transcription mediated by the coactivator alteration/deficiency in activation 3 (ADA3). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2011]

GeneCards Summary for ANKRD12 Gene

ANKRD12 (Ankyrin Repeat Domain 12) is a Protein Coding gene. An important paralog of this gene is BCORL1.

UniProtKB/Swiss-Prot for ANKRD12 Gene

  • May recruit HDACs to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANKRD12 Gene

Genomics for ANKRD12 Gene

Genomic Location for ANKRD12 Gene

Start:
9,136,228 bp from pter
End:
9,285,985 bp from pter
Size:
149,758 bases
Orientation:
Plus strand

Genomic View for ANKRD12 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ANKRD12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANKRD12 Gene

Regulatory Elements for ANKRD12 Gene

Proteins for ANKRD12 Gene

  • Protein details for ANKRD12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UB98-ANR12_HUMAN
    Recommended name:
    Ankyrin repeat domain-containing protein 12
    Protein Accession:
    Q6UB98
    Secondary Accessions:
    • O94951
    • Q658K1
    • Q6QMF7
    • Q9H231
    • Q9H784

    Protein attributes for ANKRD12 Gene

    Size:
    2062 amino acids
    Molecular mass:
    235652 Da
    Quaternary structure:
    • Interacts with the PAS region of the p160 coactivators.
    SequenceCaution:
    • Sequence=BAB15014.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

    Alternative splice isoforms for ANKRD12 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ANKRD12 Gene

Proteomics data for ANKRD12 Gene at MOPED

Post-translational modifications for ANKRD12 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ANKRD12 Gene

Domains for ANKRD12 Gene

Gene Families for ANKRD12 Gene

HGNC:
  • ANKRD :Ankyrin repeat domain containing

Protein Domains for ANKRD12 Gene

UniProtKB/Swiss-Prot:

ANR12_HUMAN
Similarity:
  • Contains 3 ANK repeats.:
    • Q6UB98
genes like me logo Genes that share domains with ANKRD12: view

Function for ANKRD12 Gene

Molecular function for ANKRD12 Gene

UniProtKB/Swiss-Prot Function: May recruit HDACs to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation

Gene Ontology (GO) - Molecular Function for ANKRD12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with ANKRD12: view

Phenotypes for ANKRD12 Gene

MGI mutant phenotypes for ANKRD12:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with ANKRD12: view

miRNA for ANKRD12 Gene

miRTarBase miRNAs that target ANKRD12

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ANKRD12 Gene

Localization for ANKRD12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ANKRD12 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ANKRD12 Gene COMPARTMENTS Subcellular localization image for ANKRD12 gene
Compartment Confidence
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for ANKRD12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with ANKRD12: view

Pathways for ANKRD12 Gene

SuperPathways for ANKRD12 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ANKRD12 Gene

None

No data available for Pathways by source for ANKRD12 Gene

Transcripts for ANKRD12 Gene

Unigene Clusters for ANKRD12 Gene

Ankyrin repeat domain 12:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ANKRD12 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15
SP1: -
SP2:
SP3:

Relevant External Links for ANKRD12 Gene

GeneLoc Exon Structure for
ANKRD12
ECgene alternative splicing isoforms for
ANKRD12

Expression for ANKRD12 Gene

mRNA expression in normal human tissues for ANKRD12 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ANKRD12 Gene

SOURCE GeneReport for Unigene cluster for ANKRD12 Gene Hs.464585

genes like me logo Genes that share expressions with ANKRD12: view

Orthologs for ANKRD12 Gene

This gene was present in the common ancestor of animals.

Orthologs for ANKRD12 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ANKRD12 36
  • 99.29 (n)
  • 98.93 (a)
ANKRD12 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ANKRD12 36
  • 88.95 (n)
  • 88.61 (a)
ANKRD12 37
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ANKRD12 36
  • 91.12 (n)
  • 90.67 (a)
ANKRD12 37
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ankrd12 36
  • 84.17 (n)
  • 82.04 (a)
Ankrd12 16
Ankrd12 37
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ANKRD12 37
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ANKRD12 37
  • 72 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ankrd12 36
  • 82.62 (n)
  • 80.91 (a)
chicken
(Gallus gallus)
Aves ANKRD12 36
  • 73.45 (n)
  • 70.16 (a)
ANKRD12 37
  • 68 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ANKRD12 37
  • 65 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii ankrd12 37
  • 48 (a)
OneToOne
wufi16c02 36
fruit fly
(Drosophila melanogaster)
Insecta CG10984 37
  • 29 (a)
OneToMany
Species with no ortholog for ANKRD12:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ANKRD12 Gene

ENSEMBL:
Gene Tree for ANKRD12 (if available)
TreeFam:
Gene Tree for ANKRD12 (if available)

Paralogs for ANKRD12 Gene

Paralogs for ANKRD12 Gene

genes like me logo Genes that share paralogs with ANKRD12: view

Variants for ANKRD12 Gene

Sequence variations from dbSNP and Humsavar for ANKRD12 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type MAF
rs894755 -- 9,226,510(-) ATAAA(A/G)TGATC intron-variant
rs976409 -- 9,217,236(-) ATGCC(C/T)TTCAA intron-variant
rs998171 -- 9,219,664(-) GCCAA(C/T)CTGGT intron-variant
rs998172 -- 9,219,463(-) ATCTT(C/T)CAAAA intron-variant
rs1034486 -- 9,251,238(-) TAACA(A/G)TATAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ANKRD12 Gene

Variant ID Type Subtype PubMed ID
nsv909364 CNV Loss 21882294
nsv131135 CNV Loss 16902084
dgv187n21 CNV Loss 19592680
esv1632576 CNV Insertion 17803354
esv28200 CNV Loss 19812545
esv2664033 CNV Deletion 23128226
esv3372 CNV Deletion 18987735
esv2716768 CNV Deletion 23290073
esv8562 CNV Loss 19470904
esv2676874 CNV Deletion 23128226
dgv54n6 CNV Loss 16902084
esv1009496 CNV Deletion 20482838
nsv2201 CNV Loss 18451855
nsv828176 CNV Loss 20364138
esv2657711 CNV Deletion 23128226

Relevant External Links for ANKRD12 Gene

HapMap Linkage Disequilibrium report
ANKRD12

Disorders for ANKRD12 Gene

Relevant External Links for ANKRD12

Genetic Association Database (GAD)
ANKRD12
Human Genome Epidemiology (HuGE) Navigator
ANKRD12
genes like me logo Genes that share disorders with ANKRD12: view

No data available for UniProtKB/Swiss-Prot for ANKRD12 Gene

Publications for ANKRD12 Gene

  1. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10048485) Nagase T. … Ohara O. (DNA Res. 1998) 2 3 4
  2. Ankyrin repeats-containing cofactors interact with ADA3 and modulate its co-activator function. (PMID: 18377363) Li C.W. … Chen J.D. (Biochem. J. 2008) 3 23
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Identification of a novel family of ankyrin repeats-containing cofactors for p160 nuclear receptor coactivators. (PMID: 15184363) Zhang A. … Chen J.D. (J. Biol. Chem. 2004) 3 4
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49

Products for ANKRD12 Gene

Sources for ANKRD12 Gene

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