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Aliases for ANKRD12 Gene

Aliases for ANKRD12 Gene

  • Ankyrin Repeat Domain 12 2 3 5
  • Ankyrin Repeat-Containing Cofactor 2 3 4
  • GAC-1 Protein 4
  • Nbla00144 3
  • KIAA0874 4
  • ANCO-2 3
  • ANCO1 3
  • GAC-1 3
  • ANCO2 4

External Ids for ANKRD12 Gene

Previous GeneCards Identifiers for ANKRD12 Gene

  • GC18P009172
  • GC18P009126

Summaries for ANKRD12 Gene

Entrez Gene Summary for ANKRD12 Gene

  • This gene encodes a member of the ankyrin repeats-containing cofactor family. These proteins may inhibit the transcriptional activity of nuclear receptors through the recruitment of histone deacetylases. The encoded protein interacts with p160 coactivators and also represses transcription mediated by the coactivator alteration/deficiency in activation 3 (ADA3). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2011]

GeneCards Summary for ANKRD12 Gene

ANKRD12 (Ankyrin Repeat Domain 12) is a Protein Coding gene. An important paralog of this gene is BCORL1.

UniProtKB/Swiss-Prot for ANKRD12 Gene

  • May recruit HDACs to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANKRD12 Gene

Genomics for ANKRD12 Gene

Regulatory Elements for ANKRD12 Gene

Enhancers for ANKRD12 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ANKRD12 on UCSC Golden Path with GeneCards custom track

Promoters for ANKRD12 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ANKRD12 on UCSC Golden Path with GeneCards custom track

Genomic Location for ANKRD12 Gene

9,136,228 bp from pter
9,285,985 bp from pter
149,758 bases
Plus strand

Genomic View for ANKRD12 Gene

Genes around ANKRD12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANKRD12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANKRD12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANKRD12 Gene

Proteins for ANKRD12 Gene

  • Protein details for ANKRD12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ankyrin repeat domain-containing protein 12
    Protein Accession:
    Secondary Accessions:
    • O94951
    • Q658K1
    • Q6QMF7
    • Q9H231
    • Q9H784

    Protein attributes for ANKRD12 Gene

    2062 amino acids
    Molecular mass:
    235652 Da
    Quaternary structure:
    • Interacts with the PAS region of the p160 coactivators.
    • Sequence=BAB15014.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

    Alternative splice isoforms for ANKRD12 Gene


neXtProt entry for ANKRD12 Gene

Proteomics data for ANKRD12 Gene at MOPED

Post-translational modifications for ANKRD12 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ANKRD12 Gene

Domains & Families for ANKRD12 Gene

Gene Families for ANKRD12 Gene

Protein Domains for ANKRD12 Gene

Suggested Antigen Peptide Sequences for ANKRD12 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 3 ANK repeats.
  • Contains 3 ANK repeats.
genes like me logo Genes that share domains with ANKRD12: view

Function for ANKRD12 Gene

Molecular function for ANKRD12 Gene

UniProtKB/Swiss-Prot Function:
May recruit HDACs to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation.

Phenotypes for ANKRD12 Gene

MGI mutant phenotypes for ANKRD12:
inferred from 1 alleles
GenomeRNAi human phenotypes for ANKRD12:
genes like me logo Genes that share phenotypes with ANKRD12: view

Animal Models for ANKRD12 Gene

MGI Knock Outs for ANKRD12:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ANKRD12 Gene

Localization for ANKRD12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ANKRD12 Gene

Subcellular locations from

Jensen Localization Image for ANKRD12 Gene COMPARTMENTS Subcellular localization image for ANKRD12 gene
Compartment Confidence
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for ANKRD12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with ANKRD12: view

Pathways & Interactions for ANKRD12 Gene

SuperPathways for ANKRD12 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ANKRD12 Gene


No data available for Pathways by source and SIGNOR curated interactions for ANKRD12 Gene

Drugs & Compounds for ANKRD12 Gene

No Compound Related Data Available

Transcripts for ANKRD12 Gene

Unigene Clusters for ANKRD12 Gene

Ankyrin repeat domain 12:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ANKRD12 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15
SP1: -

Relevant External Links for ANKRD12 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ANKRD12 Gene

mRNA expression in normal human tissues for ANKRD12 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ANKRD12 Gene

This gene is overexpressed in Liver (28.8), Fetal Brain (9.4), and Platelet (8.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ANKRD12 Gene

SOURCE GeneReport for Unigene cluster for ANKRD12 Gene Hs.464585

genes like me logo Genes that share expression patterns with ANKRD12: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for ANKRD12 Gene

Orthologs for ANKRD12 Gene

This gene was present in the common ancestor of animals.

Orthologs for ANKRD12 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ANKRD12 35
  • 88.95 (n)
  • 88.61 (a)
ANKRD12 36
  • 88 (a)
(Canis familiaris)
Mammalia ANKRD12 35
  • 91.12 (n)
  • 90.67 (a)
ANKRD12 36
  • 91 (a)
(Mus musculus)
Mammalia Ankrd12 35
  • 84.17 (n)
  • 82.04 (a)
Ankrd12 16
Ankrd12 36
  • 82 (a)
(Pan troglodytes)
Mammalia ANKRD12 35
  • 99.29 (n)
  • 98.93 (a)
ANKRD12 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Ankrd12 35
  • 82.62 (n)
  • 80.91 (a)
(Monodelphis domestica)
Mammalia ANKRD12 36
  • 79 (a)
(Ornithorhynchus anatinus)
Mammalia ANKRD12 36
  • 72 (a)
(Gallus gallus)
Aves ANKRD12 35
  • 73.45 (n)
  • 70.16 (a)
ANKRD12 36
  • 68 (a)
(Anolis carolinensis)
Reptilia ANKRD12 36
  • 65 (a)
(Danio rerio)
Actinopterygii wufi16c02 35
ankrd12 36
  • 48 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10984 36
  • 29 (a)
Species with no ortholog for ANKRD12:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ANKRD12 Gene

Gene Tree for ANKRD12 (if available)
Gene Tree for ANKRD12 (if available)

Paralogs for ANKRD12 Gene

Paralogs for ANKRD12 Gene

genes like me logo Genes that share paralogs with ANKRD12: view

Variants for ANKRD12 Gene

Sequence variations from dbSNP and Humsavar for ANKRD12 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
VAR_019425 -
rs2298546 - 9,255,720(-) CTTTA(C/T)TTTCC reference, missense
rs4798791 - 9,255,984(+) AGAAA(A/G)GATGG reference, missense
rs2298548 - 9,221,885(-) AAATG(C/G)ATTTC upstream-variant-2KB, reference, missense
rs35101529 - 9,254,437(-) TCAGG(G/T)TCATT reference, missense

Structural Variations from Database of Genomic Variants (DGV) for ANKRD12 Gene

Variant ID Type Subtype PubMed ID
nsv909364 CNV Loss 21882294
nsv131135 CNV Loss 16902084
dgv187n21 CNV Loss 19592680
esv1632576 CNV Insertion 17803354
esv28200 CNV Loss 19812545
esv2664033 CNV Deletion 23128226
esv3372 CNV Deletion 18987735
esv2716768 CNV Deletion 23290073
esv8562 CNV Loss 19470904
esv2676874 CNV Deletion 23128226
dgv54n6 CNV Loss 16902084
esv1009496 CNV Deletion 20482838
nsv2201 CNV Loss 18451855
nsv828176 CNV Loss 20364138
esv2657711 CNV Deletion 23128226

Variation tolerance for ANKRD12 Gene

Residual Variation Intolerance Score: 2.07% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.50; 85.87% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ANKRD12 Gene

Disorders for ANKRD12 Gene

Relevant External Links for ANKRD12

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ANKRD12 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANKRD12 Gene

Publications for ANKRD12 Gene

  1. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10048485) Nagase T. … Ohara O. (DNA Res. 1998) 2 3 4 67
  2. Ankyrin repeats-containing cofactors interact with ADA3 and modulate its co-activator function. (PMID: 18377363) Li C.W. … Chen J.D. (Biochem. J. 2008) 3 23
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Clinical significance of Ankyrin repeat domain 12 expression in colorectal cancer. (PMID: 23718802) Bai R. … Zheng S. (J. Exp. Clin. Cancer Res. 2013) 3
  5. The functional interactome landscape of the human histone deacetylase family. (PMID: 23752268) Joshi P. … Cristea I.M. (Mol. Syst. Biol. 2013) 3

Products for ANKRD12 Gene

Sources for ANKRD12 Gene