Aliases for ANKRD12 Gene
Aliases for ANKRD12 Gene
External Ids for ANKRD12 Gene
- HGNC: 29135
- Entrez Gene: 23253
- Ensembl: ENSG00000101745
- OMIM: 610616
- UniProtKB: Q6UB98
Previous GeneCards Identifiers for ANKRD12 Gene
- GC18P009172
- GC18P009126
Summaries for ANKRD12 Gene
-
This gene encodes a member of the ankyrin repeats-containing cofactor family. These proteins may inhibit the transcriptional activity of nuclear receptors through the recruitment of histone deacetylases. The encoded protein interacts with p160 coactivators and also represses transcription mediated by the coactivator alteration/deficiency in activation 3 (ADA3). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2011]
GeneCards Summary for ANKRD12 Gene
ANKRD12 (Ankyrin Repeat Domain 12) is a Protein Coding gene. An important paralog of this gene is ANKRD11.
UniProtKB/Swiss-Prot for ANKRD12 Gene
-
May recruit HDACs to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation.
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANKRD12 Gene
Genomics for ANKRD12 Gene
Regulatory Elements for ANKRD12 Gene
Enhancers for ANKRD12 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around ANKRD12 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for ANKRD12 Gene
- Chromosome:
- 18
- Start:
- 9,136,228 bp from pter
- End:
- 9,285,985 bp from pter
- Size:
- 149,758 bases
- Orientation:
- Plus strand
Genomic View for ANKRD12 Gene
Genes around ANKRD12 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 18p11.22 by Ensembl
- 18p11.22 by Entrez Gene
- 18p11.22 by HGNC
ANKRD12 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ANKRD12 Gene
Proteins for ANKRD12 Gene
-
Protein details for ANKRD12 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q6UB98-ANR12_HUMAN
- Recommended name:
- Ankyrin repeat domain-containing protein 12
- Protein Accession:
- Q6UB98
- O94951
- Q658K1
- Q6QMF7
- Q9H231
- Q9H784
Protein attributes for ANKRD12 Gene
- Size:
- 2062 amino acids
- Molecular mass:
- 235652 Da
- Quaternary structure:
-
- Interacts with the PAS region of the p160 coactivators.
- SequenceCaution:
-
- Sequence=BAB15014.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};
Protein Expression for ANKRD12 Gene
Post-translational modifications for ANKRD12 Gene
Other Protein References for ANKRD12 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for ANKRD12
-
Abcam antibodies for ANKRD12
- Invitrogen Antibodies for ANKRD12
- antibodies-online Antibodies for ANKRD12: See all 16
- GeneTex ANKRD12 antibody for ANKRD12
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for ANKRD12
- Origene Custom Protein Services for ANKRD12
- Novus Biologicals proteins for ANKRD12
- Search GeneTex for Proteins for ANKRD12
Assay Products
- antibodies-online Kits for ANKRD12: See all 9
No data available for DME Specific Peptides for ANKRD12 Gene
Domains & Families for ANKRD12 Gene
Gene Families for ANKRD12 Gene
Protein Domains for ANKRD12 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for ANKRD12 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for ANKRD12 Gene
Function for ANKRD12 Gene
Molecular function for ANKRD12 Gene
- UniProtKB/Swiss-Prot Function:
- May recruit HDACs to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation.
Phenotypes for ANKRD12 Gene
- GenomeRNAi human phenotypes for ANKRD12:
Animal Model Products
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-
-
ViGene Biosciences lentiviral particle packaged cDNA for ANKRD12 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for ANKRD12 gene
- Search ViGene Biosciences for ANKRD12
CRISPR Products
-
OriGene CRISPR knockouts for ANKRD12
-
Santa Cruz Biotechnology (SCBT) CRISPR for ANKRD12
- GenScript: Design CRISPR guide RNA sequences for ANKRD12
miRNA for ANKRD12 Gene
- miRTarBase miRNAs that target ANKRD12
-
- hsa-mir-342-5p (MIRT038230)
- hsa-mir-365a-3p (MIRT044032)
- hsa-mir-17-5p (MIRT148865)
- hsa-mir-19a-3p (MIRT148866)
- hsa-mir-19b-3p (MIRT148867)
- hsa-mir-20a-5p (MIRT148868)
- hsa-mir-93-5p (MIRT148869)
- hsa-mir-106b-5p (MIRT148874)
- hsa-mir-20b-5p (MIRT148878)
- hsa-mir-519d-3p (MIRT148882)
- hsa-mir-374a-5p (MIRT148913)
- hsa-mir-155-5p (MIRT376128)
- hsa-mir-1273e (MIRT376130)
- hsa-mir-3692-3p (MIRT449018)
- hsa-mir-140-3p (MIRT449019)
- hsa-mir-144-3p (MIRT449020)
miRNA Products
- Search ViGene Biosciences for ANKRD12
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for ANKRD12
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-
ViGene Biosciences ready-to-package AAV shRNAs for ANKRD12 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for ANKRD12
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ANKRD12
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for ANKRD12
-
ViGene Biosciences adenoviral particle packaged cDNA for ANKRD12 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for ANKRD12 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for ANKRD12 gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ANKRD12 Gene
Localization for ANKRD12 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ANKRD12 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005829 | cytosol | IDA | -- |
Pathways & Interactions for ANKRD12 Gene
No Data Available
No data available for Pathways by source and SIGNOR curated interactions for ANKRD12 Gene
Transcripts for ANKRD12 Gene
mRNA/cDNA for ANKRD12 Gene
- (19) REFSEQ mRNAs :
- (15) Additional mRNA sequences :
- (244) Selected AceView cDNA sequences:
- (9) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for ANKRD12 Gene
- Ankyrin repeat domain 12:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for ANKRD12
-
Santa Cruz Biotechnology (SCBT) CRISPR for ANKRD12
- GenScript: Design CRISPR guide RNA sequences for ANKRD12
miRNA Products
- Search ViGene Biosciences for ANKRD12
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for ANKRD12
- Browse OriGene Inhibitory RNA Products For ANKRD12
-
ViGene Biosciences ready-to-package AAV shRNAs for ANKRD12 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for ANKRD12
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ANKRD12
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||||||||||||
| SP2: | |||||||||||||||||||||||||||||||
| SP3: |
Expression for ANKRD12 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- Hematopoietic Stem Cells Hematopoietic Bone Marrow
- Hematopoietic Bone Marrow
- Eye (Sensory Organs)
This gene is overexpressed in Liver (28.8), Fetal Brain (9.4), and Platelet (8.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ANKRD12 Gene
NURSA nuclear receptor signaling pathways regulating expression of ANKRD12 Gene:
ANKRD12SOURCE GeneReport for Unigene cluster for ANKRD12 Gene:
Hs.464585Evidence on tissue expression from TISSUES for ANKRD12 Gene
- Nervous system(4.5)
- Blood(4.1)
Primer Products
-
OriGene qPCR primer pairs for ANKRD12
No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ANKRD12 Gene
Orthologs for ANKRD12 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ANKRD12 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | ANKRD12 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | ANKRD12 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Ankrd12 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Ankrd12 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | ANKRD12 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | ANKRD12 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | ANKRD12 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | ANKRD12 35 |
|
OneToOne | |
| zebrafish (Danio rerio) |
Actinopterygii | ankrd12 35 |
|
OneToOne | |
| wufi16c02 34 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | CG10984 35 |
|
OneToMany |
- Species where no ortholog for ANKRD12 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for ANKRD12 Gene
(23) SIMAP similar genes for ANKRD12 Gene using alignment to 8 proteins:
Variants for ANKRD12 Gene
| SNP ID | Clin | Chr 18 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs864622035 | Uncertain significance | 9,255,860(+) | GTGTT(G/T)ATAAA | reference, missense | |
| rs1000015089 | -- | 9,165,823(+) | ATTAA(C/G)TCATC | intron-variant | |
| rs1000026401 | -- | 9,251,185(+) | AACAC(C/T)TCTCT | intron-variant | |
| rs1000046153 | -- | 9,168,018(+) | CTTAC(A/G)TTTAT | intron-variant | |
| rs1000047148 | -- | 9,173,094(+) | AGACT(A/G)AGTTT | intron-variant |
Residual Variation Intolerance Score:
2.07% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
8.50;
85.87% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for ANKRD12 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- ANKRD12
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANKRD12 Gene
Disorders for ANKRD12 Gene
Relevant External Links for ANKRD12
No disorders were found for ANKRD12 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANKRD12 Gene
Publications for ANKRD12 Gene
- Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10048485) Nagase T. … Ohara O. (DNA Res. 1998) 2 3 4 64
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
- Ankyrin repeats-containing cofactors interact with ADA3 and modulate its co-activator function. (PMID: 18377363) Li C.W. … Chen J.D. (Biochem. J. 2008) 3 22 64
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
- Identification of a novel family of ankyrin repeats-containing cofactors for p160 nuclear receptor coactivators. (PMID: 15184363) Zhang A. … Chen J.D. (J. Biol. Chem. 2004) 3 4 64
Products for ANKRD12 Gene
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- Novus Biologicals Antibodies for ANKRD12
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- Novus Biologicals
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- antibodies-online Antibodies for ANKRD12: See all 16
- antibodies-online Kits for ANKRD12: See all 9
- Search antibodies-online for proteins
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- GeneTex ANKRD12 antibody for ANKRD12
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- ViGene Biosciences adenoviral particle packaged cDNA for ANKRD12 gene
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- Horizon Cell Lines for ANKRD12
- Cyagen custom Knockout/knockin (KOKI) mouse models for ANKRD12
- VectorBuilder custom plasmid, inducible vectors for ANKRD12
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ANKRD12
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for ANKRD12 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
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- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
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- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
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- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
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- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer