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ANKRD11 Gene

protein-coding   GIFtS: 49
GCID: GC16M089334

Ankyrin Repeat Domain 11

  See ANKRD11-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ankyrin Repeat Domain 111 2     T132
ANCO12 3 5     Ankyrin Repeat Domain-Containing Protein 112
Ankyrin Repeat-Containing Cofactor 12 3     Nasopharyngeal Carcinoma Susceptibility Protein2
ANCO-12     KBGS5
LZ162     

External Ids:    HGNC: 213161   Entrez Gene: 291232   Ensembl: ENSG000001675227   OMIM: 6111925   UniProtKB: Q6UB993   

Export aliases for ANKRD11 gene to outside databases

Previous GC identifers: GC16M089095 GC16M089077 GC16M087861 GC16M075032


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ANKRD11 Gene:
This locus encodes an ankryin repeat domain-containing protein. The encoded protein inhibits ligand-dependent
activation of transcription. Mutations in this gene have been associated with KBG syndrome, which is
characterized by macrodontia, distinctive craniofacial features, short stature, skeletal anomalies, global
developmental delay, seizures and intellectual disability. Alternatively spliced transcript variants have been
described. Related pseudogenes exist on chromosomes 2 and X. (provided by RefSeq, Jan 2012)

GeneCards Summary for ANKRD11 Gene:
ANKRD11 (ankyrin repeat domain 11) is a protein-coding gene. Diseases associated with ANKRD11 include kbg syndrome, and nasal cavity lymphoma. An important paralog of this gene is BARD1.

UniProtKB/Swiss-Prot: ANR11_HUMAN, Q6UB99
Function: May recruit HDACs to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent
transactivation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the ANKRD11 gene promoter:
         Pax-5   AP-1   ATF-2   ARP-1   c-Jun   NF-kappaB1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for ANKRD11

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ANKRD11


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q24.3   Ensembl cytogenetic band:  16q24.3   HGNC cytogenetic band: 16q24.3

ANKRD11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ANKRD11 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M089334:  view genomic region     (about GC identifiers)

Start:
89,334,035 bp from pter      End:
89,556,969 bp from pter
Size:
222,935 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ANR11_HUMAN, Q6UB99 (See protein sequence)
Recommended Name: Ankyrin repeat domain-containing protein 11  
Size: 2663 amino acids; 297913 Da
Subunit: Interacts with the PAS region of the p160 coactivators
Sequence caution: Sequence=AAH69013.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential
poly-A sequence;
Secondary accessions: Q6NTG1 Q6QMF8

Explore the universe of human proteins at neXtProt for ANKRD11: NX_Q6UB99

Explore proteomics data for ANKRD11 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ANKRD11 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001243111.1  NP_001243112.1  NP_037407.4  

    ENSEMBL proteins: 
     ENSP00000367581   ENSP00000301030   ENSP00000330815   ENSP00000458043   ENSP00000454550  
     ENSP00000367583   ENSP00000455008  

    ANKRD11 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for ANKRD11

     
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    antibodies-online peptides for ANKRD11

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    antibodies-online antibodies for ANKRD11 (18 products) 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ANKRD: Ankyrin repeat domain containing

    2 InterPro protein domains:
     IPR002110 Ankyrin_rpt
     IPR020683 Ankyrin_rpt-contain_dom

    Graphical View of Domain Structure for InterPro Entry Q6UB99

    ProtoNet protein and cluster: Q6UB99

    1 Blocks protein domain: IPB002110 Ankyrin repeat signature

    UniProtKB/Swiss-Prot: ANR11_HUMAN, Q6UB99
    Similarity: Contains 4 ANK repeats


    Find genes that share domains with ANKRD11           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ANR11_HUMAN, Q6UB99
    Function: May recruit HDACs to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent
    transactivation

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    Find genes that share ontologies with ANKRD11           About GenesLikeMe


    Phenotypes:
         12 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Ankrd11):
     behavior/neurological  cardiovascular system  craniofacial  embryogenesis  growth/size/body 
     hematopoietic system  homeostasis/metabolism  immune system  mortality/aging  other 
     skeleton  vision/eye 

    Find genes that share phenotypes with ANKRD11           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for ANKRD11

    miRNA
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    miRTarBase miRNAs that target ANKRD11:
    hsa-mir-149-5p (MIRT045610), hsa-mir-615-3p (MIRT040440), hsa-mir-186-5p (MIRT045278), hsa-mir-335-5p (MIRT019021), hsa-mir-1914-3p (MIRT035776), hsa-mir-98-5p (MIRT027843), hsa-mir-193b-3p (MIRT041338)

    Block miRNA regulation of human, mouse, rat ANKRD11 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ANKRD11 (see all 36):
    hsa-miR-136 hsa-miR-548k hsa-let-7a-2* hsa-miR-383 hsa-miR-4330 hsa-miR-497* hsa-miR-365 hsa-miR-3163
    SwitchGear 3'UTR luciferase reporter plasmidANKRD11 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ANKRD11

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANKRD11


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ANR11_HUMAN, Q6UB99: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005886plasma membrane IDA--

    Find genes that share ontologies with ANKRD11           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ANKRD11
    Interactions:

        Search GeneGlobe Interaction Network for ANKRD11

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    Selected Interacting proteins for ANKRD11 (Q6UB993 ENSP000003010304) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NCOA2Q155963, ENSP000003999684I2D: score=3 STRING: ENSP00000399968
    HDAC4P565243, ENSP000002646064I2D: score=1 STRING: ENSP00000264606
    HDAC3O153793, ENSP000003029674I2D: score=3 STRING: ENSP00000302967
    HDAC5Q9UQL63, ENSP000002259834I2D: score=1 STRING: ENSP00000225983
    NCOA3Q9Y6Q93, ENSP000003610664I2D: score=1 STRING: ENSP00000361066
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001701in utero embryonic development IEA--
    GO:0001894tissue homeostasis IEA--
    GO:0035264multicellular organism growth IEA--
    GO:0042475odontogenesis of dentin-containing tooth IMP--
    GO:0048705skeletal system morphogenesis IMP--

    Find genes that share ontologies with ANKRD11           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ANKRD11 (ANR11)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ANKRD11 gene (3 alternative transcripts): 
    NM_001256182.1  NM_001256183.1  NM_013275.5  

    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000378330 ENST00000301030(uc002fmx.1 uc002fmy.1 uc002fnc.1)
    ENST00000330736(uc002fnb.1) ENST00000562194 ENST00000568100 ENST00000562275(uc002fnd.3)
    ENST00000378332(uc002fne.3) ENST00000564553 ENST00000562816 ENST00000567736(uc002fnf.1 uc002fng.1)
    ENST00000568924 ENST00000563291 ENST00000566858 ENST00000567699 ENST00000568512
    ENST00000566973
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate ANKRD11 (see all 36):
    hsa-miR-136 hsa-miR-548k hsa-let-7a-2* hsa-miR-383 hsa-miR-4330 hsa-miR-497* hsa-miR-365 hsa-miR-3163
    SwitchGear 3'UTR luciferase reporter plasmidANKRD11 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ANKRD11
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    GenScript: all cDNA clones in your preferred vector: ANKRD11 (NM_013275)
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      QuantiTect SYBR Green Assays in human, mouse, rat ANKRD11
      QuantiFast Probe-based Assays in human, mouse, rat ANKRD11

    Selected AceView cDNA sequences (see all 354):

    BQ268914 BI767472 AI656275 AW236564 BF965882 BQ269184 AY131227 AY533563 
    BM991500 AI312555 BQ881442 AA886700 BE677290 AI799049 BM473611 AW945998 
    AA701303 BC069013 BF194969 BC017437 BC041059 AA761505 AW847764 BU196389 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ANKRD11 (see all 13)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c · 9d ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b · 13c ^ 14a · 14b ^ 15a ·
    SP1:                    -     -     -                       -           -     -     -     -     -     -     -                       -     -     -               
    SP2:                    -     -     -                       -           -     -     -     -     -     -     -                       -     -     -               
    SP3:                                                        -           -     -     -     -     -                                                               
    SP4:                                                                                                                                -     -     -               
    SP5:                                                        -           -     -     -     -     -     -     -                                                   

    ExUns: 15b ^ 16 ^ 17 ^ 18 ^ 19 ^ 20
    SP1:                                    
    SP2:                                    
    SP3:                                    
    SP4:                                    
    SP5:                                    


    ECgene alternative splicing isoforms for ANKRD11

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ANKRD11 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAAGCTGACA
    ANKRD11 Expression
    About this image


    ANKRD11 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    ANKRD11 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ANKRD11 Protein Expression
        Custom PCR Arrays for ANKRD11
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANKRD11

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ANKRD11 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ankrd111 , 5 ankyrin repeat domain 111, 5 79.9(n)1
    80.99(a)1
      8 (72.00 cM)5
    770871  NM_001081379.21  NP_001074848.21 
     1228833375 
    chicken
    (Gallus gallus)
    Aves ANKRD111 ankyrin repeat domain 11 73.45(n)
    71.48(a)
      415845  XM_414205.4  XP_414205.3 
    lizard
    (Anolis carolinensis)
    Reptilia ANKRD116
    ankyrin repeat domain 11
    67(a)
    1 ↔ 1
    GL343487.1(265378-319310)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.238202 Xenopus laevis transcribed sequence with strong similarity more 75.86(n)    CB941509.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufi04c062 Transcribed sequence with weak similarity to protein more 73.94(n)    57062649 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG109846
    --
    30(a)
    1 → many
    3L(12743219-12746502)


    ENSEMBL Gene Tree for ANKRD11 (if available)
    TreeFam Gene Tree for ANKRD11 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ANKRD11 gene
    BARD12  BCOR2  TONSL2  ANKRD322  ANKRD122  ANKRD312  BCORL12  
    6 SIMAP similar genes for ANKRD11 using alignment to 9 protein entries:     ANR11_HUMAN (see all proteins):
    ANKRD12    OSBPL1A    PPP1R12A    PPP1R27    DKFZp761E1322    MTPN

    Find genes that share paralogs with ANKRD11           About GenesLikeMe


    4 Pseudogenes.org Pseudogenes for ANKRD11
    PGOHUM00000240111 PGOHUM00000262437 PGOHUM00000235167 PGOHUM00000241588


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ANKRD11 (see all 5694)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1509546801,2
    --75031830(+) CCTCCG/TCAGGG 3 -- int10--------
    rs1863064781,2
    --75031964(+) GGAAAA/GGGGTG 3 -- int10--------
    rs1918084881,2
    --89333559(+) TGCTCC/TTGTTT 3 -- ds50010--------
    rs169646801,2
    C,F--89333575(+) CAGCTC/TCTACA 3 -- ds50014Minor allele frequency- T:0.02NA 262
    rs1166760711,2
    C,F--89333613(+) GTCTGT/AGCAAA 3 -- ds50011Minor allele frequency- A:0.03WA 118
    rs1456318841,2
    C--89333628(+) GAGGAC/TGAGGG 3 -- ds50010--------
    rs1837617781,2
    C--89333663(+) AAAAGC/GTAACA 3 -- ds50010--------
    rs1144047001,2
    F--89333680(+) TAGGAA/TAAAGG 3 -- ds50011Minor allele frequency- T:0.02WA 118
    rs1866044641,2
    --89333752(+) AGCCTC/GCACCT 3 -- ds50010--------
    rs1469901141,2
    C--89333764(+) CTGGGA/TTCAAA 3 -- ds50010--------

    HapMap Linkage Disequilibrium report for ANKRD11 (89334035 - 89556969 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for ANKRD11 (see all 67):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2665887CNV Deletion23128226
    esv2715156CNV Deletion23290073
    esv2715145CNV Deletion23290073
    esv1451902CNV Deletion17803354
    esv994831CNV Deletion20482838
    esv2715151CNV Deletion23290073
    esv2715143CNV Deletion23290073
    esv2662057CNV Deletion23128226
    esv2715158CNV Deletion23290073
    esv2715148CNV Deletion23290073

    Human Gene Mutation Database (HGMD): ANKRD11
    Site Specific Mutation Identification with PCR Assays
    2 Copy Number PCR Panels containing ANKRD11:
    Birth Defects
    Intellectual Disability
    SeqTarget long-range PCR primers for resequencing ANKRD11
    DNA2.0 Custom Variant and Variant Library Synthesis for ANKRD11

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 611192   
    OMIM disorders: 148050  
    UniProtKB/Swiss-Prot: ANR11_HUMAN, Q6UB99
  • KBG syndrome (KBGS) [MIM:148050]: A syndrome characterized by macrodontia of the upper central incisors,
    distinctive craniofacial findings, short stature, skeletal anomalies, and neurologic involvement that includes
    global developmental delay, seizures, and intellectual disability. Note=The disease is caused by mutations
    affecting the gene represented in this entry

  • 5 diseases for ANKRD11:    
    About MalaCards
    kbg syndrome    nasal cavity lymphoma    16q24.3 microdeletion syndrome    intellectual disability
    short stature

    4 diseases from the University of Copenhagen DISEASES database for ANKRD11:
    KBG syndrome     Nasal cavity lymphoma     Carcinoma     Breast cancer

    Find genes that share disorders with ANKRD11           About GenesLikeMe

    Genetic Association Database (GAD): ANKRD11

    Export disorders for ANKRD11 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for ANKRD11 gene, integrated from 10 sources (see all 26):
    (articles sorted by number of sources associating them with ANKRD11)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mutations in ANKRD11 cause KBG syndrome, characterized by intellectual disability, skeletal malformations, and macrodontia. (PubMed id 21782149)1, 2 Sirmaci A....Tekin M. (Am. J. Hum. Genet. 2011)
    2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Identification of a novel family of ankyrin repeats-containing cofactors for p160 nuclear receptor coactivators. (PubMed id 15184363)1, 2 Zhang A....Chen J.D. (J. Biol. Chem. 2004)
    5. Gene expression profiling in human fetal liver and identification of tissue- and developmental-stage-specific genes through compiled expression profiles and efficient cloning of full-length cDNAs. (PubMed id 11483580)1, 3 Yu Y....He F. (Genome Res. 2001)
    6. Identification of ANKRD11 as a p53 coactivator. (PubMed id 18840648)1, 9 Neilsen P.M....Callen D.F. (J. Cell. Sci. 2008)
    7. Partial deletion of ANKRD11 results in the KBG phenotype distinct from the 16q24.3 microdeletion syndrome. (PubMed id 23494856)1 Khalifa M....Duby J. (Am. J. Med. Genet. A 2013)
    8. The CCND1 c.870G&gt;A polymorphism is a risk factor for t(11;14)(q13;q32) multiple myeloma. (PubMed id 23502783)1 Weinhold N....Hemminki K. (Nat. Genet. 2013)
    9. Neurobehavioral phenotype observed in KBG syndrome caused by ANKRD11 mutations. (PubMed id 23184435)1 Lo-Castro A....Curatolo P. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2013)
    10. The functional interactome landscape of the human histone deacetylase family. (PubMed id 23752268)1 Joshi P....Cristea I.M. (Mol. Syst. Biol. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 29123 HGNC: 21316 AceView: ANKRD11 Ensembl:ENSG00000167522 euGenes: HUgn29123
    ECgene: ANKRD11 H-InvDB: ANKRD11

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ANKRD11 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ANKRD11 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for ANKRD11 gene:
    Search GeneIP for patents involving ANKRD11

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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