ANKRD10 Gene
protein-coding GIFtS : 43
GCID: GC13 M111530
ankyrin repeat domain 10
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Aliasesfor ANKRD10 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Ankyrin Repeat Domain 10 1 2 FLJ200931 Ankyrin Repeat Domain-Containing Protein 102
Export aliases for ANKRD10 gene to outside databases Previous GC identifers: GC13M105918 GC13M110367 GC13M109228 GC13M110328 GC13M092129
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Summariesfor ANKRD10 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section --
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Genomic Viewsfor ANKRD10 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000013.10 NC_018924.1 NT_009952.14 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the ANKRD10 gene promoter: c-Fos AP-1 JunB Fra-1 FosB Olf-1 Nkx2-5 RORalpha2 JunD c-Jun Other transcription factors Search SABiosciences Chromatin IP Primers for ANKRD10 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat ANKRD10
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 13q34 Ensembl cytogenetic band: 13q34 HGNC cytogenetic band: 13q33.3 ANKRD10 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 13 GeneLoc Exon Structure
GeneLoc location for GC13M111530: view genomic region
(about GC identifiers )
Start:
111,530,887 bp from pter
End:
111,567,416 bp from pter
Size:
36,530 bases
Orientation:
minus strand
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Proteinsfor ANKRD10 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: ANR10_HUMAN, Q9NXR5 (See
protein sequence )Recommended Name: Ankyrin repeat domain-containing protein 10 Size : 420 amino acids; 44768 Da
Secondary accessions : Q5VW12 Q9BV12Alternative splicing : 2 isoforms : Q9NXR5-1 Q9NXR5-2 Explore the universe of human proteins at neXtProt for ANKRD10: NX_Q9NXR5 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q9NXR5 ANKRD10 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_060134.2 ENSEMBL proteins: ENSP00000267339 ENSP00000312534 ENSP00000431927 ENSP00000364911 Human Recombinant Protein Products: ANKRD10 Antibody Products: Assay Products for ANKRD10:
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Protein
Domains / Familiesfor ANKRD10 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
ANKRD10 for domains About GeneDecksing 2 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q9NXR5 ProtoNet protein and cluster: Q9NXR5
1 Blocks protein family : IPB002110 Ankyrin repeat signature UniProtKB/Swiss-Prot: ANR10_HUMAN, Q9NXR5 Similarity : Contains 4 ANK repeats
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Functionfor ANKRD10 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for ANKRD10 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for ANKRD10OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: ANKRD10 (NM_017664 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ANKRD10 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat ANKRD10
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANKRD10
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Pathways & Interactionsfor ANKRD10 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ANKRD10 STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)2 Interacting proteins for ANKRD10 (ENSP00000267339 4 ) via UniProtKB, MINT, STRING , and/or I2D About this table
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Drugs & Compoundsfor ANKRD10 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for ANKRD10 Search CenterWatch for drugs/clinical trials and news about ANKRD10 / ANR10
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Transcriptsfor ANKRD10 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for ANKRD10 gene: NM_017664.2 Unigene Cluster for ANKRD10:
Ankyrin repeat domain 10 Hs.525163 [show with all ESTs ] Unigene Representative Sequence: BX641022 11 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000267339 (uc001vrm.3 uc001vrn.3 ) ENST00000485844 ENST00000310847 (uc001vro.1 )ENST00000465753 ENST00000489973 ENST00000475809 ENST00000494859 ENST00000464579 ENST00000463156 ENST00000460846 ENST00000375758 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for ANKRD10 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for ANKRD10OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: ANKRD10 (NM_017664 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ANKRD10 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat ANKRD10
Additional cDNA sequence: AK000100.1 AK000111.1 AK026017.1 AK094222.1 AK095763.1 AK096083.1 AK123341.1 AK125100.1 BC001727.1 BC039715.1 BX641022.1
24/29 DOTS entries (see all 29 ): DT.100881168 DT.95276051
DT.120781207 DT.100881189 DT.92447817 DT.443103 DT.92447818 DT.100762108 DT.100033981 DT.100881179 DT.97779451 DT.102841664 DT.120781162 DT.120781186 DT.120781125 DT.100881180 DT.120781164 DT.92447822 DT.120781143 DT.120781158 DT.100037276 DT.100037277 DT.120781118 DT.120781195 24/601 AceView cDNA sequences (see all 601 ):
CD518452 AA938437 CA426731 Z39071 BP343416 N56645 BM458269 H25692 CR604585 AA749191 BX482199 BQ712642 BE327536 BQ011664 BX101033 AI373049 AI671401 W86674 R67070 BM722622 BX504788 AA780453 AA249553 AA487380 GeneLoc Exon Structure 5/17 Alternative Splicing Database (ASD) splice patterns (SP) for ANKRD10 (see all 17 ) About this scheme ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c · 7d ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b · 10c · 10d · SP1 :           -   -             -   -   -   -   -   -   -   -   -   -   -         SP2 :           -   -             -   -   -   -   -   -   -   -       -         SP3 :           -   -             -   -   -   -   -   -     -   -     -         SP4 :                         -   -   -   -   -   -     -       -         SP5 :           -   -             -     -   -   -   -   -   -   -   -   -        
ExUns: 10e · 10f · 10g · 10h · 10i ^ 11a · 11b · 11c · 11d ^ 12a · 12b · 12c SP1 :     -   -   -         -         SP2 :     -   -   -                 SP3 :                         SP4 :     -   -   -                 SP5 :                        
ECgene alternative splicing isoforms for ANKRD10
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Expression for ANKRD10 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section ANKRD10 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: TATTTTCTTT
About this image ANKRD10 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table 1 LifeMap In Vivo Development Anatomical Compartment/Cell Tissue Anatomical Compartment
Cell Category (developmental path) Testis Seminiferous Tubules Secondary Spermatocyte Germ Cells, Male Gametocytes Expression: Positive Negative
Selective markerExperimental details:
Curated
Microarrays
In-situ hybridization
See ANKRD10 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for ANKRD10 SOURCE GeneReport for Unigene cluster: Hs.525163 SABiosciences Custom PCR Arrays for ANKRD10 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for ANKRD10Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat ANKRD10 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat ANKRD10 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat ANKRD10 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANKRD10
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Orthologsfor ANKRD10 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of chordates.
Orthologs for ANKRD10 gene from 4/15 species (see all 15 ) About this table
Organism
Taxonomic classification
Gene
Description
Human Similarity
Orthology Type
Details
chicken (Gallus gallus)
Aves
ANKRD101
ankyrin repeat domain 10
77.21(n) 72.51(a)
 
418760 NM_001030815.1 NP_001025986.1
lizard (Anolis carolinensis)
Reptilia
ANKRD106
--
64(a)
1 ↔ 1
3(104564787-104596786)
tropical clawed frog (Xenopus tropicalis)
Amphibia
Str.120122
Transcribed sequence with weak similarity to protein more
75.76(n)
 
137725148
zebrafish (Danio rerio)
Actinopterygii
zgc553532
similar to ankyrin repeat domain 10
74.69(n)
 
393955 BC044376.1
ENSEMBL Gene Tree for ANKRD10 (if available)TreeFam Gene Tree for ANKRD10 (if available)
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Paralogsfor ANKRD10 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for ANKRD10 gene ANKRD37 2 14 SIMAP similar genes for ANKRD10 using alignment to 3 protein entries: ANR10_HUMAN (see all proteins ):DKFZp686B07190 ANKRD37 ANK2 ANKRD28 ANKRD44 ANKRD53 LOC91526 ASB2 ANK1 ANKRD42 PPP1R12A ANKRD52 KIDINS220 USH1G
ANKRD10 for paralogs About GeneDecksing
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Genomic Variantsfor ANKRD10 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 13 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for ANKRD10 (111530887 - 111567416 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 7 variations for ANKRD10 1 CNV : 66555 6 Indels : 101863 41682 61356 45123 40017 25133
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing ANKRD10
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Disorders
/ Diseasesfor ANKRD10 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
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Publicationsfor ANKRD10 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for ANKRD10 gene integrated from 9 sources : (articles sorted by number of sources associating them with ANKRD10) Utopia : connect your pdf to the dynamic world of online information
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 1 , 2 Ota T.... Sugano S. (2004) Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201) 1 Abdelmohsen K....Gorospe M. (2009) The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823) 2 Dunham A.... Ross M.T. (2004) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 2 Gerhard D.S....Malek J. (2004) Multiple functional categories of proteins identified in an in vitro cellular ubiquitin affinity extract using shotgun peptide sequencing. (PubMed id 12938929) 1 Gururaja T....Anderson D.C. (2003) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 Strausberg R.L....Marra M.A. (2002)
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External Searches for ANKRD10 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing ANKRD10 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing ANKRD10 gene
(According to HUGE )
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Specialized Databases showing ANKRD10 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for ANKRD10 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for ANKRD10 gene: Search GeneIP for patents involving ANKRD10 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor ANKRD10 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for ANKRD10 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for ANKRD10 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for ANKRD10 OriGene Protein Over-expression Lysate for ANKRD10 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for ANKRD10 OriGene 3'-UTR Clone for ANKRD10 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for ANKRD10 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for ANKRD10 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs OriGene Purified Protein for ANKRD10 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for ANKRD10 OriGene Custom Protein Services for ANKRD10 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ANKRD10 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing ANKRD10 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat ANKRD10 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat ANKRD10 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat ANKRD10 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat ANKRD10
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ANKRD10 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANKRD10
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Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat ANKRD10
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