Aliases for ANKRD10 Gene
External Ids for ANKRD10 Gene
- HGNC: 20265
- Entrez Gene: 55608
- Ensembl: ENSG00000088448
- UniProtKB: Q9NXR5
Previous GeneCards Identifiers for ANKRD10 Gene
- GC13M105918
- GC13M110367
- GC13M109228
- GC13M110328
- GC13M111530
- GC13M092129
Summaries for ANKRD10 Gene
GeneCards Summary for ANKRD10 Gene
ANKRD10 (Ankyrin Repeat Domain 10) is a Protein Coding gene. An important paralog of this gene is ANKRD37.
No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANKRD10 Gene
Genomics for ANKRD10 Gene
Regulatory Elements for ANKRD10 Gene
Enhancers for ANKRD10 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around ANKRD10 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for ANKRD10 Gene
- Chromosome:
- 13
- Start:
- 110,878,540 bp from pter
- End:
- 110,915,107 bp from pter
- Size:
- 36,568 bases
- Orientation:
- Minus strand
Genomic View for ANKRD10 Gene
Genes around ANKRD10 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 13q34 by Ensembl
- 13q34 by Entrez Gene
- 13q34 by HGNC
ANKRD10 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ANKRD10 Gene
Proteins for ANKRD10 Gene
-
Protein details for ANKRD10 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9NXR5-ANR10_HUMAN
- Recommended name:
- Ankyrin repeat domain-containing protein 10
- Protein Accession:
- Q9NXR5
- Q5VW12
- Q9BV12
Protein attributes for ANKRD10 Gene
- Size:
- 420 amino acids
- Molecular mass:
- 44768 Da
- Quaternary structure:
- No Data Available
Protein Expression for ANKRD10 Gene
Post-translational modifications for ANKRD10 Gene
Other Protein References for ANKRD10 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for ANKRD10
- Novus Biologicals Antibodies for ANKRD10
-
Abcam antibodies for ANKRD10
- Invitrogen Antibodies for ANKRD10
- GeneTex Scn1a antibody for ANKRD10
-
Santa Cruz Biotechnology (SCBT) Antibodies for ANKRD10
Protein Products
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OriGene Purified Proteins for ANKRD10
- Search Origene for MassSpec and Protein Over-expression Lysates for ANKRD10
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- Search GeneTex for Proteins for ANKRD10
-
Abcam proteins for ANKRD10
Assay Products
No data available for DME Specific Peptides for ANKRD10 Gene
Domains & Families for ANKRD10 Gene
Gene Families for ANKRD10 Gene
Protein Domains for ANKRD10 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for ANKRD10 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for ANKRD10 Gene
Function for ANKRD10 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 25416956 |
Phenotypes for ANKRD10 Gene
- GenomeRNAi human phenotypes for ANKRD10:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
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-
-
ViGene Biosciences lentiviral particle packaged cDNA for ANKRD10 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for ANKRD10 gene
- Search ViGene Biosciences for ANKRD10
CRISPR Products
-
OriGene CRISPR knockouts for ANKRD10
-
Santa Cruz Biotechnology (SCBT) CRISPR for ANKRD10
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miRNA for ANKRD10 Gene
- miRTarBase miRNAs that target ANKRD10
miRNA Products
- Search ViGene Biosciences for ANKRD10
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for ANKRD10
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ViGene Biosciences ready-to-package AAV shRNAs for ANKRD10 gene
Clone Products
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- VectorBuilder custom plasmid, inducible vectors for ANKRD10
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ANKRD10
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for ANKRD10
-
ViGene Biosciences adenoviral particle packaged cDNA for ANKRD10 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for ANKRD10 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for ANKRD10 gene
Flow Cytometry Products
No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ANKRD10 Gene
Localization for ANKRD10 Gene
| Compartment | Confidence |
|---|---|
| cytosol | 4 |
| nucleus | 3 |
| cytoskeleton | 2 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ANKRD10 Gene
Pathways & Interactions for ANKRD10 Gene
No Data Available
Interacting Proteins for ANKRD10 Gene
Selected Interacting proteins:
ENSP00000267339
Q9NXR5-ANR10_HUMAN
for ANKRD10 Gene via
STRING
IID
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0060828 | regulation of canonical Wnt signaling pathway | IBA | -- |
No data available for Pathways by source and SIGNOR curated interactions for ANKRD10 Gene
Transcripts for ANKRD10 Gene
mRNA/cDNA for ANKRD10 Gene
- (2) REFSEQ mRNAs :
- (11) Additional mRNA sequences :
- (601) Selected AceView cDNA sequences:
- (11) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for ANKRD10 Gene
CRISPR Products
-
OriGene CRISPR knockouts for ANKRD10
-
Santa Cruz Biotechnology (SCBT) CRISPR for ANKRD10
- GenScript: Design CRISPR guide RNA sequences for ANKRD10
miRNA Products
- Search ViGene Biosciences for ANKRD10
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for ANKRD10
- Browse OriGene Inhibitory RNA Products For ANKRD10
-
ViGene Biosciences ready-to-package AAV shRNAs for ANKRD10 gene
Clone Products
-
OriGene ORF clones in human for ANKRD10
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for ANKRD10
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for ANKRD10
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ANKRD10
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7a | · | 7b | · | 7c | · | 7d | ^ | 8 | ^ | 9a | · | 9b | · | 9c | ^ | 10a | · | 10b | · | 10c | · | 10d | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP13: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||
| SP14: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||
| SP15: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP16: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP17: |
| ExUns: | 10e | · | 10f | · | 10g | · | 10h | · | 10i | ^ | 11a | · | 11b | · | 11c | · | 11d | ^ | 12a | · | 12b | · | 12c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | |||||||||||||||||||
| SP2: | - | - | - | ||||||||||||||||||||
| SP3: | |||||||||||||||||||||||
| SP4: | - | - | - | ||||||||||||||||||||
| SP5: | |||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||
| SP7: | |||||||||||||||||||||||
| SP8: | |||||||||||||||||||||||
| SP9: | |||||||||||||||||||||||
| SP10: | - | - | - | ||||||||||||||||||||
| SP11: | - | - | - | - | |||||||||||||||||||
| SP12: | |||||||||||||||||||||||
| SP13: | |||||||||||||||||||||||
| SP14: | |||||||||||||||||||||||
| SP15: | - | - | - | - | |||||||||||||||||||
| SP16: | |||||||||||||||||||||||
| SP17: |
Expression for ANKRD10 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Testis (Reproductive System)
- Secondary Spermatocyte Seminiferous Tubules
-
Gonad
- Secondary Spermatocyte Seminiferous Tubules
- Bone (Muscoskeletal System)
-
Uterus (Reproductive System)
-
Colon (Gastrointestinal Tract)
-
Prostate (Endocrine System)
-
Spleen (Hematopoietic System)
-
Gall Bladder (Hepatobiliary System)
-
Lung (Respiratory System)
-
Kidney (Urinary System)
-
Adrenal Gland (Endocrine System)
-
Stomach (Gastrointestinal Tract)
-
Ovary (Reproductive System)
This gene is overexpressed in Bone (54.8) and CD8 Tcells (13.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ANKRD10 Gene
NURSA nuclear receptor signaling pathways regulating expression of ANKRD10 Gene:
ANKRD10SOURCE GeneReport for Unigene cluster for ANKRD10 Gene:
Hs.525163Evidence on tissue expression from TISSUES for ANKRD10 Gene
- Eye(4.4)
- Intestine(4.4)
- Nervous system(4.3)
- Lung(2.7)
Primer Products
-
OriGene qPCR primer pairs and template standards for ANKRD10
-
OriGene qPCR primer pairs for ANKRD10
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ANKRD10 Gene
Orthologs for ANKRD10 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ANKRD10 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | ANKRD10 34 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Ankrd10 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Ankrd10 34 16 35 |
|
||
| cow (Bos Taurus) |
Mammalia | ANKRD10 34 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | ANKRD10 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | ANKRD10 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | ANKRD10 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | ANKRD10 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | ankrd10 34 |
|
||
| Str.12012 34 |
|
||||
| zebrafish (Danio rerio) |
Actinopterygii | ankrd10b 34 35 |
|
||
| ankrd10a 35 |
|
OneToMany | |||
| zgc55353 34 |
|
||||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.11213 34 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
OneToMany |
- Species where no ortholog for ANKRD10 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for ANKRD10 Gene
(14) SIMAP similar genes for ANKRD10 Gene using alignment to 4 proteins:
Variants for ANKRD10 Gene
| SNP ID | Clin | Chr 13 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000007324 | -- | 110,903,531(+) | CTTAC(A/G)GATGC | intron-variant | |
| rs1000160980 | -- | 110,892,018(+) | TAAGA(C/T)ATCTT | intron-variant | |
| rs1000165963 | -- | 110,883,041(+) | TGGAA(A/G)CAGGA | intron-variant | |
| rs1000197587 | -- | 110,894,889(+) | TTGTA(A/C)AAAAT | intron-variant | |
| rs1000278966 | -- | 110,898,051(+) | ACAAA(A/G)TATTA | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv1039n106 | CNV | deletion | 24896259 |
| dgv3402n54 | CNV | gain | 21841781 |
| dgv3403n54 | CNV | loss | 21841781 |
| dgv3404n54 | CNV | gain+loss | 21841781 |
| esv1002915 | CNV | deletion | 20482838 |
| esv1666847 | CNV | deletion | 17803354 |
| esv2018264 | CNV | deletion | 18987734 |
| esv2504656 | CNV | deletion | 19546169 |
| esv2583876 | CNV | deletion | 19546169 |
| esv2748046 | CNV | deletion | 23290073 |
| esv29570 | CNV | loss | 19812545 |
| esv3077 | CNV | loss | 18987735 |
| esv3551085 | CNV | deletion | 23714750 |
| esv6134 | CNV | loss | 19470904 |
| nsv1044340 | CNV | gain | 25217958 |
| nsv1070616 | CNV | deletion | 25765185 |
| nsv1120429 | CNV | deletion | 24896259 |
| nsv1134352 | CNV | deletion | 24896259 |
| nsv1149745 | CNV | deletion | 26484159 |
| nsv563148 | CNV | loss | 21841781 |
| nsv563149 | CNV | loss | 21841781 |
| nsv563150 | CNV | loss | 21841781 |
| nsv563158 | CNV | gain | 21841781 |
| nsv563159 | CNV | loss | 21841781 |
| nsv563160 | CNV | gain | 21841781 |
| nsv563161 | CNV | gain+loss | 21841781 |
| nsv958124 | CNV | deletion | 24416366 |
Residual Variation Intolerance Score:
21.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.58;
30.48% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for ANKRD10 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- ANKRD10
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANKRD10 Gene
Disorders for ANKRD10 Gene
Relevant External Links for ANKRD10
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- ANKRD10
No disorders were found for ANKRD10 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANKRD10 Gene
Publications for ANKRD10 Gene
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
- A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64
- Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3 64
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3 64
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 64
Products for ANKRD10 Gene
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- Santa Cruz Biotechnology (SCBT) Antibodies for ANKRD10
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- Santa Cruz Biotechnology (SCBT) CRISPR for ANKRD10
- Horizon Cell Lines for ANKRD10
- Cyagen custom Knockout/knockin (KOKI) mouse models for ANKRD10
- VectorBuilder custom plasmid, inducible vectors for ANKRD10
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ANKRD10
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for ANKRD10 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
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