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Aliases for ANKRA2 Gene

Aliases for ANKRA2 Gene

  • Ankyrin Repeat Family A Member 2 2 3 5
  • Ankyrin Repeat, Family A (RFXANK-Like), 2 2 3
  • RFXANK-Like Protein 2 3 4
  • ANKRA 3 4
  • Ankyrin Repeat Family A Protein 2 3

External Ids for ANKRA2 Gene

Previous GeneCards Identifiers for ANKRA2 Gene

  • GC05M071653
  • GC05M073081
  • GC05M072886
  • GC05M072932
  • GC05M072883
  • GC05M068053
  • GC05M072849

Summaries for ANKRA2 Gene

GeneCards Summary for ANKRA2 Gene

ANKRA2 (Ankyrin Repeat Family A Member 2) is a Protein Coding gene. Among its related pathways are Signaling events mediated by HDAC Class II. GO annotations related to this gene include histone deacetylase binding and low-density lipoprotein particle binding. An important paralog of this gene is RFXANK.

UniProtKB/Swiss-Prot for ANKRA2 Gene

  • May regulate the interaction between the 3M complex and the histone deacetylases HDAC4 and HDAC5 (PubMed:25752541). May also regulate LRP2/megalin (By similarity).

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANKRA2 Gene

Genomics for ANKRA2 Gene

Regulatory Elements for ANKRA2 Gene

Enhancers for ANKRA2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05G073029 1.2 Ensembl ENCODE 46.4 +534.5 534507 3.2 PKNOX1 ARNT ZFP64 ZNF133 SIN3A FEZF1 YY1 GLIS2 GATA2 FOS ANKRA2 ENSG00000272525 TMEM171 ENSG00000272081 FCHO2 LOC728549 GC05P073101
GH05G073495 1.1 ENCODE 20.5 +67.6 67582 5.1 HDGF PKNOX1 FOXA2 CREB3L1 ARNT ARID4B SIN3A DMAP1 YBX1 ZNF2 ANKRA2 ENSG00000272525 UTP15 FCHO2 BTF3 GC05M073449
GH05G073795 1.5 Ensembl ENCODE dbSUPER 13.9 -231.1 -231108 2.7 ARID4B SIN3A FEZF1 ZNF548 FOS SP3 YY2 ZNF518A ATF4 RCOR2 UTP15 FCHO2 ANKRA2 RNU7-196P ENSG00000272525 ARHGEF28 LOC102725145 ENSG00000184084
GH05G072840 1.8 FANTOM5 Ensembl ENCODE dbSUPER 11.2 +722.8 722801 4.0 PKNOX1 ATF1 SIN3A BRCA1 GTF3C2 ELK1 GATA2 ZNF416 FOS REST FCHO2 ENSG00000249085 UTP15 TNPO1 PTCD2 ANKRA2 ARHGEF28 GC05P072869
GH05G073443 1.3 ENCODE dbSUPER 14.5 +119.4 119428 6.3 PKNOX1 FOXA2 ATF1 CREB3L1 SIN3A ZNF2 GLIS2 ZNF202 ZNF263 SP3 ANKRA2 BTF3 FOXD1-AS1 GC05P073385
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ANKRA2 on UCSC Golden Path with GeneCards custom track

Promoters for ANKRA2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000182435 305 2401 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 YY1 SLC30A9 KLF13 SP3

Genomic Location for ANKRA2 Gene

Chromosome:
5
Start:
73,552,200 bp from pter
End:
73,565,705 bp from pter
Size:
13,506 bases
Orientation:
Minus strand

Genomic View for ANKRA2 Gene

Genes around ANKRA2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANKRA2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANKRA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANKRA2 Gene

Proteins for ANKRA2 Gene

  • Protein details for ANKRA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H9E1-ANRA2_HUMAN
    Recommended name:
    Ankyrin repeat family A protein 2
    Protein Accession:
    Q9H9E1

    Protein attributes for ANKRA2 Gene

    Size:
    313 amino acids
    Molecular mass:
    34272 Da
    Quaternary structure:
    • Interacts (via ANK repeats) with CCDC8 (via PxLPxI/L motif); mediates the interaction with the 3M complex which is composed of CCDC8, CUL7 and OBSL1 (PubMed:25752541). Interacts (via ANK repeats) with HDAC4 (via PxLPxI/L motif) (PubMed:22649097). Interacts (via ANK repeats) with HDAC5 (via PxLPxI/L motif) (PubMed:22649097). Interacts (via ANK repeats) with LRP2/megalin (via PxLPxI/L motif) (PubMed:22649097). Interacts (via ANK repeats) with RFX7 (via PxLPxI/L motif) (PubMed:25752541). Interacts with AHRR (By similarity). Interacts with NEK6 (PubMed:20873783).

    Three dimensional structures from OCA and Proteopedia for ANKRA2 Gene

neXtProt entry for ANKRA2 Gene

Post-translational modifications for ANKRA2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ANKRA2 Gene

No data available for DME Specific Peptides for ANKRA2 Gene

Domains & Families for ANKRA2 Gene

Gene Families for ANKRA2 Gene

Protein Domains for ANKRA2 Gene

Suggested Antigen Peptide Sequences for ANKRA2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H9E1

UniProtKB/Swiss-Prot:

ANRA2_HUMAN :
  • The ankyrin repeats, mainly ANK 2, ANK 3 and ANK 4, mediate interaction with a wide array of PxLPxI/L motif-containing proteins including HDAC4 and LRP2. The PxLPxI/L motif of interactors can contain a Ser or a Thr residue in position 2, which phosphorylation prevents the interaction with ANKRA2.
Domain:
  • The ankyrin repeats, mainly ANK 2, ANK 3 and ANK 4, mediate interaction with a wide array of PxLPxI/L motif-containing proteins including HDAC4 and LRP2. The PxLPxI/L motif of interactors can contain a Ser or a Thr residue in position 2, which phosphorylation prevents the interaction with ANKRA2.
genes like me logo Genes that share domains with ANKRA2: view

Function for ANKRA2 Gene

Molecular function for ANKRA2 Gene

UniProtKB/Swiss-Prot Function:
May regulate the interaction between the 3M complex and the histone deacetylases HDAC4 and HDAC5 (PubMed:25752541). May also regulate LRP2/megalin (By similarity).

Gene Ontology (GO) - Molecular Function for ANKRA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003712 transcription cofactor activity IBA --
GO:0005515 protein binding IPI 25416956
GO:0031625 ubiquitin protein ligase binding IDA 25752541
GO:0042826 histone deacetylase binding IPI 22649097
GO:0050750 low-density lipoprotein particle receptor binding IPI 22649097
genes like me logo Genes that share ontologies with ANKRA2: view
genes like me logo Genes that share phenotypes with ANKRA2: view

Animal Model Products

CRISPR Products

miRNA for ANKRA2 Gene

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ANKRA2 Gene

Localization for ANKRA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ANKRA2 Gene

Cytoplasm, cytoskeleton. Membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ANKRA2 gene
Compartment Confidence
cytosol 5
cytoskeleton 4
nucleus 4
plasma membrane 2

Gene Ontology (GO) - Cellular Components for ANKRA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA 11095640
GO:0005856 cytoskeleton IEA --
GO:0016020 membrane IDA 11095640
genes like me logo Genes that share ontologies with ANKRA2: view

Pathways & Interactions for ANKRA2 Gene

genes like me logo Genes that share pathways with ANKRA2: view

Pathways by source for ANKRA2 Gene

1 BioSystems pathway for ANKRA2 Gene

Gene Ontology (GO) - Biological Process for ANKRA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006357 regulation of transcription from RNA polymerase II promoter IBA --
GO:0008150 biological_process ND --
GO:0043254 regulation of protein complex assembly IDA 25752541
genes like me logo Genes that share ontologies with ANKRA2: view

No data available for SIGNOR curated interactions for ANKRA2 Gene

Drugs & Compounds for ANKRA2 Gene

No Compound Related Data Available

Transcripts for ANKRA2 Gene

Unigene Clusters for ANKRA2 Gene

Ankyrin repeat, family A (RFXANK-like), 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ANKRA2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c · 8d · 8e
SP1: - -
SP2: - - -
SP3: -
SP4: - -
SP5:

Relevant External Links for ANKRA2 Gene

GeneLoc Exon Structure for
ANKRA2
ECgene alternative splicing isoforms for
ANKRA2

Expression for ANKRA2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ANKRA2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ANKRA2 Gene

This gene is overexpressed in Adipocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ANKRA2 Gene



Protein tissue co-expression partners for ANKRA2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ANKRA2 Gene:

ANKRA2

SOURCE GeneReport for Unigene cluster for ANKRA2 Gene:

Hs.239154

Evidence on tissue expression from TISSUES for ANKRA2 Gene

  • Kidney(4.2)
  • Nervous system(2.3)
genes like me logo Genes that share expression patterns with ANKRA2: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ANKRA2 Gene

Orthologs for ANKRA2 Gene

This gene was present in the common ancestor of animals.

Orthologs for ANKRA2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ANKRA2 34 35
  • 99.47 (n)
dog
(Canis familiaris)
Mammalia ANKRA2 34 35
  • 93.5 (n)
cow
(Bos Taurus)
Mammalia ANKRA2 34 35
  • 92.97 (n)
oppossum
(Monodelphis domestica)
Mammalia ANKRA2 35
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ankra2 34
  • 89.24 (n)
mouse
(Mus musculus)
Mammalia Ankra2 34 16 35
  • 88.78 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ANKRA2 35
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves ANKRA2 34 35
  • 80.94 (n)
lizard
(Anolis carolinensis)
Reptilia ANKRA2 35
  • 92 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ankra2 34
  • 79.17 (n)
Str.3915 34
zebrafish
(Danio rerio)
Actinopterygii ankra2 34 35
  • 72.72 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG5846 35
  • 29 (a)
OneToMany
Species where no ortholog for ANKRA2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ANKRA2 Gene

ENSEMBL:
Gene Tree for ANKRA2 (if available)
TreeFam:
Gene Tree for ANKRA2 (if available)

Paralogs for ANKRA2 Gene

Paralogs for ANKRA2 Gene

(1) SIMAP similar genes for ANKRA2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ANKRA2: view

Variants for ANKRA2 Gene

Sequence variations from dbSNP and Humsavar for ANKRA2 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1000120750 -- 73,564,025(+) CTCCA(G/T)CACTC intron-variant, upstream-variant-2KB
rs1000309739 -- 73,555,995(+) TGGGA(A/G)GATCA intron-variant
rs1000316267 -- 73,565,931(+) GCTCC(C/G)ATTGA intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs1000329196 -- 73,566,316(+) GGTGC(C/T)AGTCA intron-variant, upstream-variant-2KB
rs1000456824 -- 73,563,693(+) AGATA(C/T)ATTAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ANKRA2 Gene

Variant ID Type Subtype PubMed ID
nsv830346 CNV loss 17160897
nsv830347 CNV gain 17160897

Variation tolerance for ANKRA2 Gene

Residual Variation Intolerance Score: 20.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.57; 12.37% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ANKRA2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ANKRA2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANKRA2 Gene

Disorders for ANKRA2 Gene

Relevant External Links for ANKRA2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ANKRA2

No disorders were found for ANKRA2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANKRA2 Gene

Publications for ANKRA2 Gene

  1. Ankyrin repeats of ANKRA2 recognize a PxLPxL motif on the 3M syndrome protein CCDC8. (PMID: 25752541) Nie J. … Yang X.J. (Structure 2015) 3 4 64
  2. Sequence-specific recognition of a PxLPxI/L motif by an ankyrin repeat tumbler lock. (PMID: 22649097) Xu C. … Min J. (Sci. Signal. 2012) 3 4 64
  3. Characterization of hNek6 interactome reveals an important role for its short N-terminal domain and colocalization with proteins at the centrosome. (PMID: 20873783) Vaz Meirelles G. … Kobarg J. (J. Proteome Res. 2010) 3 4 64
  4. Identification of the ankyrin repeat proteins ANKRA and RFXANK as novel partners of class IIa histone deacetylases. (PMID: 15964851) Wang A.H. … Yang X.J. (J. Biol. Chem. 2005) 3 22 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64

Products for ANKRA2 Gene

Sources for ANKRA2 Gene

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