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Aliases for ANKRA2 Gene

Aliases for ANKRA2 Gene

  • Ankyrin Repeat Family A Member 2 2 3
  • Ankyrin Repeat, Family A (RFXANK-Like), 2 2 3 5
  • RFXANK-Like Protein 2 3 4
  • ANKRA 3 4

External Ids for ANKRA2 Gene

Previous GeneCards Identifiers for ANKRA2 Gene

  • GC05M071653
  • GC05M073081
  • GC05M072886
  • GC05M072932
  • GC05M072883
  • GC05M068053
  • GC05M072849

Summaries for ANKRA2 Gene

GeneCards Summary for ANKRA2 Gene

ANKRA2 (Ankyrin Repeat Family A Member 2) is a Protein Coding gene. Among its related pathways are Signaling events mediated by HDAC Class II. GO annotations related to this gene include histone deacetylase binding and low-density lipoprotein particle binding. An important paralog of this gene is RFXANK.

UniProtKB/Swiss-Prot for ANKRA2 Gene

  • May facilitate endocytosis by linking megalin to components of the cytoskeleton or endocytic machinery.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANKRA2 Gene

Genomics for ANKRA2 Gene

Regulatory Elements for ANKRA2 Gene

Enhancers for ANKRA2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ANKRA2 on UCSC Golden Path with GeneCards custom track

Promoters for ANKRA2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ANKRA2 on UCSC Golden Path with GeneCards custom track

Genomic Location for ANKRA2 Gene

73,552,200 bp from pter
73,565,705 bp from pter
13,506 bases
Minus strand

Genomic View for ANKRA2 Gene

Genes around ANKRA2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANKRA2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANKRA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANKRA2 Gene

Proteins for ANKRA2 Gene

  • Protein details for ANKRA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ankyrin repeat family A protein 2
    Protein Accession:

    Protein attributes for ANKRA2 Gene

    313 amino acids
    Molecular mass:
    34272 Da
    Quaternary structure:
    • Interacts with the cytoplasmic tail of LRP2/megalin, HDAC4, HDAC5, and HDAC9, all these interactions occur via the recognition of a PxLPxI/L motif. Interacts with AHRR (By similarity). Interacts with NEK6.

    Three dimensional structures from OCA and Proteopedia for ANKRA2 Gene

neXtProt entry for ANKRA2 Gene

Proteomics data for ANKRA2 Gene at MOPED

Post-translational modifications for ANKRA2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ANKRA2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ANKRA2 Gene

Domains & Families for ANKRA2 Gene

Gene Families for ANKRA2 Gene

Protein Domains for ANKRA2 Gene

Suggested Antigen Peptide Sequences for ANKRA2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • The three central ANK repeats mediate binding to the PxLPxI/L motif of interactors.
  • Contains 5 ANK repeats.
  • The three central ANK repeats mediate binding to the PxLPxI/L motif of interactors.
  • Contains 5 ANK repeats.
genes like me logo Genes that share domains with ANKRA2: view

Function for ANKRA2 Gene

Molecular function for ANKRA2 Gene

UniProtKB/Swiss-Prot Function:
May facilitate endocytosis by linking megalin to components of the cytoskeleton or endocytic machinery.

Gene Ontology (GO) - Molecular Function for ANKRA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003712 transcription cofactor activity IBA --
genes like me logo Genes that share ontologies with ANKRA2: view
genes like me logo Genes that share phenotypes with ANKRA2: view

Animal Model Products

CRISPR Products

miRNA for ANKRA2 Gene

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ANKRA2 Gene

Localization for ANKRA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ANKRA2 Gene

Cytoplasm, cytoskeleton. Membrane; Peripheral membrane protein.

Subcellular locations from

Jensen Localization Image for ANKRA2 Gene COMPARTMENTS Subcellular localization image for ANKRA2 gene
Compartment Confidence
cytosol 5
cytoskeleton 4
nucleus 4
plasma membrane 2

Gene Ontology (GO) - Cellular Components for ANKRA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IDA 11095640
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with ANKRA2: view

Pathways & Interactions for ANKRA2 Gene

genes like me logo Genes that share pathways with ANKRA2: view

Pathways by source for ANKRA2 Gene

1 BioSystems pathway for ANKRA2 Gene

Gene Ontology (GO) - Biological Process for ANKRA2 Gene


No data available for SIGNOR curated interactions for ANKRA2 Gene

Drugs & Compounds for ANKRA2 Gene

No Compound Related Data Available

Transcripts for ANKRA2 Gene

Unigene Clusters for ANKRA2 Gene

Ankyrin repeat, family A (RFXANK-like), 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ANKRA2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c · 8d · 8e
SP1: - -
SP2: - - -
SP3: -
SP4: - -

Relevant External Links for ANKRA2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ANKRA2 Gene

mRNA expression in normal human tissues for ANKRA2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ANKRA2 Gene

This gene is overexpressed in Adipocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ANKRA2 Gene

SOURCE GeneReport for Unigene cluster for ANKRA2 Gene Hs.239154

genes like me logo Genes that share expression patterns with ANKRA2: view

Protein tissue co-expression partners for ANKRA2 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ANKRA2 Gene

Orthologs for ANKRA2 Gene

This gene was present in the common ancestor of animals.

Orthologs for ANKRA2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ANKRA2 35
  • 92.97 (n)
  • 96.81 (a)
  • 97 (a)
(Canis familiaris)
Mammalia ANKRA2 35
  • 93.5 (n)
  • 97.44 (a)
  • 97 (a)
(Mus musculus)
Mammalia Ankra2 35
  • 88.78 (n)
  • 95.19 (a)
Ankra2 16
Ankra2 36
  • 95 (a)
(Pan troglodytes)
Mammalia ANKRA2 35
  • 99.47 (n)
  • 99.68 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Ankra2 35
  • 89.24 (n)
  • 96.49 (a)
(Monodelphis domestica)
Mammalia ANKRA2 36
  • 91 (a)
(Ornithorhynchus anatinus)
Mammalia ANKRA2 36
  • 87 (a)
(Gallus gallus)
Aves ANKRA2 35
  • 80.94 (n)
  • 92.65 (a)
  • 93 (a)
(Anolis carolinensis)
Reptilia ANKRA2 36
  • 92 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ankra2 35
  • 79.17 (n)
  • 87.5 (a)
Str.3915 35
(Danio rerio)
Actinopterygii ankra2 35
  • 72.72 (n)
  • 82.19 (a)
ankra2 36
  • 80 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5846 36
  • 29 (a)
Species with no ortholog for ANKRA2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ANKRA2 Gene

Gene Tree for ANKRA2 (if available)
Gene Tree for ANKRA2 (if available)

Paralogs for ANKRA2 Gene

Paralogs for ANKRA2 Gene

(1) SIMAP similar genes for ANKRA2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ANKRA2: view

Variants for ANKRA2 Gene

Sequence variations from dbSNP and Humsavar for ANKRA2 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs703876 -- 73,557,075(-) GTTTA(A/T)ACTTA intron-variant
rs703877 -- 73,557,949(-) CAGGC(A/G)CATGC intron-variant
rs703878 -- 73,558,694(-) CTGGA(C/T)GTGGT intron-variant
rs703879 -- 73,559,154(+) GTGGG(A/G)TGAGA intron-variant
rs703880 -- 73,560,299(-) cacca(C/T)gaaaa intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ANKRA2 Gene

Variant ID Type Subtype PubMed ID
nsv830346 CNV Loss 17160897
nsv830347 CNV Gain 17160897

Variation tolerance for ANKRA2 Gene

Residual Variation Intolerance Score: 20.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.57; 12.37% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ANKRA2 Gene

Disorders for ANKRA2 Gene

Relevant External Links for ANKRA2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ANKRA2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANKRA2 Gene

Publications for ANKRA2 Gene

  1. Sequence-specific recognition of a PxLPxI/L motif by an ankyrin repeat tumbler lock. (PMID: 22649097) Xu C. … Min J. (Sci. Signal. 2012) 3 4 67
  2. Identification of the ankyrin repeat proteins ANKRA and RFXANK as novel partners of class IIa histone deacetylases. (PMID: 15964851) Wang A.H. … Yang X.J. (J. Biol. Chem. 2005) 3 23
  3. Assignment of ankyrin repeat, family A (RFXANK-like) 2 (ANKRA2) to human chromosome 5q12-->q13 by radiation hybrid mapping and somatic cell hybrid PCR. (PMID: 10965114) Rader K. … Arden K.C. (Cytogenet. Cell Genet. 2000) 2 3
  4. Ankyrin repeats of ANKRA2 recognize a PxLPxL motif on the 3M syndrome protein CCDC8. (PMID: 25752541) Nie J. … Yang X.J. (Structure 2015) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for ANKRA2 Gene

Sources for ANKRA2 Gene