Aliases for ANKRA2 Gene
Aliases for ANKRA2 Gene
External Ids for ANKRA2 Gene
- HGNC: 13208
- Entrez Gene: 57763
- Ensembl: ENSG00000164331
- OMIM: 605787
- UniProtKB: Q9H9E1
Previous GeneCards Identifiers for ANKRA2 Gene
- GC05M071653
- GC05M073081
- GC05M072886
- GC05M072932
- GC05M072883
- GC05M068053
- GC05M072849
Summaries for ANKRA2 Gene
GeneCards Summary for ANKRA2 Gene
ANKRA2 (Ankyrin Repeat Family A Member 2) is a Protein Coding gene. Among its related pathways are Signaling events mediated by HDAC Class II. GO annotations related to this gene include histone deacetylase binding and low-density lipoprotein particle binding. An important paralog of this gene is RFXANK.
UniProtKB/Swiss-Prot for ANKRA2 Gene
-
May regulate the interaction between the 3M complex and the histone deacetylases HDAC4 and HDAC5 (PubMed:25752541). May also regulate LRP2/megalin (By similarity).
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANKRA2 Gene
Genomics for ANKRA2 Gene
Regulatory Elements for ANKRA2 Gene
Enhancers for ANKRA2 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around ANKRA2 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the ANKRA2 gene promoter:
Regulatory Element Products
Genomic Location for ANKRA2 Gene
- Chromosome:
- 5
- Start:
- 73,552,200 bp from pter
- End:
- 73,565,705 bp from pter
- Size:
- 13,506 bases
- Orientation:
- Minus strand
Genomic View for ANKRA2 Gene
Genes around ANKRA2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 5q13.2 by Ensembl
- 5q13.2 by Entrez Gene
- 5q13.2 by HGNC
ANKRA2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ANKRA2 Gene
Proteins for ANKRA2 Gene
-
Protein details for ANKRA2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9H9E1-ANRA2_HUMAN
- Recommended name:
- Ankyrin repeat family A protein 2
- Protein Accession:
- Q9H9E1
Protein attributes for ANKRA2 Gene
- Size:
- 313 amino acids
- Molecular mass:
- 34272 Da
- Quaternary structure:
-
- Interacts (via ANK repeats) with CCDC8 (via PxLPxI/L motif); mediates the interaction with the 3M complex which is composed of CCDC8, CUL7 and OBSL1 (PubMed:25752541). Interacts (via ANK repeats) with HDAC4 (via PxLPxI/L motif) (PubMed:22649097). Interacts (via ANK repeats) with HDAC5 (via PxLPxI/L motif) (PubMed:22649097). Interacts (via ANK repeats) with LRP2/megalin (via PxLPxI/L motif) (PubMed:22649097). Interacts (via ANK repeats) with RFX7 (via PxLPxI/L motif) (PubMed:25752541). Interacts with AHRR (By similarity). Interacts with NEK6 (PubMed:20873783).
Protein Expression for ANKRA2 Gene
Post-translational modifications for ANKRA2 Gene
Other Protein References for ANKRA2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for ANKRA2
-
Abcam antibodies for ANKRA2
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- antibodies-online Antibodies for ANKRA2: See all 33
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-
Santa Cruz Biotechnology (SCBT) Antibodies for ANKRA2
Protein Products
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OriGene Purified Proteins for ANKRA2
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- antibodies-online Proteins for ANKRA2: See all 9
- Search antibodies-online for peptides
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-
Abcam proteins for ANKRA2
Assay Products
- antibodies-online Kits for ANKRA2: See all 9
No data available for DME Specific Peptides for ANKRA2 Gene
Domains & Families for ANKRA2 Gene
Gene Families for ANKRA2 Gene
Protein Domains for ANKRA2 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for ANKRA2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9H9E1UniProtKB/Swiss-Prot:
ANRA2_HUMAN :- The ankyrin repeats, mainly ANK 2, ANK 3 and ANK 4, mediate interaction with a wide array of PxLPxI/L motif-containing proteins including HDAC4 and LRP2. The PxLPxI/L motif of interactors can contain a Ser or a Thr residue in position 2, which phosphorylation prevents the interaction with ANKRA2.
- Domain:
-
- The ankyrin repeats, mainly ANK 2, ANK 3 and ANK 4, mediate interaction with a wide array of PxLPxI/L motif-containing proteins including HDAC4 and LRP2. The PxLPxI/L motif of interactors can contain a Ser or a Thr residue in position 2, which phosphorylation prevents the interaction with ANKRA2.
Function for ANKRA2 Gene
Molecular function for ANKRA2 Gene
- UniProtKB/Swiss-Prot Function:
- May regulate the interaction between the 3M complex and the histone deacetylases HDAC4 and HDAC5 (PubMed:25752541). May also regulate LRP2/megalin (By similarity).
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003712 | transcription cofactor activity | IBA | -- |
| GO:0005515 | protein binding | IPI | 25416956 |
| GO:0031625 | ubiquitin protein ligase binding | IDA | 25752541 |
| GO:0042826 | histone deacetylase binding | IPI | 22649097 |
| GO:0050750 | low-density lipoprotein particle receptor binding | IPI | 22649097 |
Phenotypes for ANKRA2 Gene
Animal Model Products
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-
-
ViGene Biosciences lentiviral particle packaged cDNA for ANKRA2 gene
-
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CRISPR Products
-
OriGene CRISPR knockouts for ANKRA2
-
Santa Cruz Biotechnology (SCBT) CRISPR for ANKRA2
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miRNA for ANKRA2 Gene
- miRTarBase miRNAs that target ANKRA2
miRNA Products
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Inhibitory RNA Products
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ViGene Biosciences ready-to-package AAV shRNAs for ANKRA2 gene
Clone Products
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for ANKRA2
-
ViGene Biosciences adenoviral particle packaged cDNA for ANKRA2 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for ANKRA2 gene
-
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Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ANKRA2 Gene
Localization for ANKRA2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ANKRA2 Gene
- Cytoplasm, cytoskeleton. Membrane; Peripheral membrane protein.
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| cytoskeleton | 4 |
| nucleus | 4 |
| plasma membrane | 2 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IBA | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005829 | cytosol | IDA | 11095640 |
| GO:0005856 | cytoskeleton | IEA | -- |
| GO:0016020 | membrane | IDA | 11095640 |
Pathways & Interactions for ANKRA2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Signaling events mediated by HDAC Class II | ||
Pathways by source for ANKRA2 Gene
1 BioSystems pathway for ANKRA2 Gene
Interacting Proteins for ANKRA2 Gene
Selected Interacting proteins:
ENSP00000296785
Q9H9E1-ANRA2_HUMAN
for ANKRA2 Gene via
STRING
UniProtKB
IID
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006357 | regulation of transcription from RNA polymerase II promoter | IBA | -- |
| GO:0008150 | biological_process | ND | -- |
| GO:0043254 | regulation of protein complex assembly | IDA | 25752541 |
No data available for SIGNOR curated interactions for ANKRA2 Gene
Transcripts for ANKRA2 Gene
mRNA/cDNA for ANKRA2 Gene
- (3) REFSEQ mRNAs :
- (4) Additional mRNA sequences :
- (153) Selected AceView cDNA sequences:
- (8) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for ANKRA2 Gene
CRISPR Products
-
OriGene CRISPR knockouts for ANKRA2
-
Santa Cruz Biotechnology (SCBT) CRISPR for ANKRA2
- GenScript: Design CRISPR guide RNA sequences for ANKRA2
miRNA Products
- Search ViGene Biosciences for ANKRA2
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for ANKRA2
- Browse OriGene Inhibitory RNA Products For ANKRA2
-
ViGene Biosciences ready-to-package AAV shRNAs for ANKRA2 gene
Clone Products
-
OriGene ORF clones in human for ANKRA2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for ANKRA2
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for ANKRA2
- VectorBuilder custom plasmid, inducible vectors for ANKRA2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ANKRA2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | ^ | 7 | ^ | 8a | · | 8b | · | 8c | · | 8d | · | 8e |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||||||||||
| SP2: | - | - | - | ||||||||||||||||||||||||||
| SP3: | - | ||||||||||||||||||||||||||||
| SP4: | - | - | |||||||||||||||||||||||||||
| SP5: |
Expression for ANKRA2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Blood (Hematopoietic System)
This gene is overexpressed in Adipocyte (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ANKRA2 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of ANKRA2 Gene:
ANKRA2SOURCE GeneReport for Unigene cluster for ANKRA2 Gene:
Hs.239154Evidence on tissue expression from TISSUES for ANKRA2 Gene
- Kidney(4.2)
- Nervous system(2.3)
Primer Products
-
OriGene qPCR primer pairs for ANKRA2
-
OriGene qPCR primer pairs and template standards for ANKRA2
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ANKRA2 Gene
Orthologs for ANKRA2 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ANKRA2 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | ANKRA2 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | ANKRA2 34 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | ANKRA2 35 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Ankra2 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Ankra2 34 16 35 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | ANKRA2 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | ANKRA2 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | ANKRA2 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | ankra2 34 |
|
||
| Str.3915 34 |
|
||||
| zebrafish (Danio rerio) |
Actinopterygii | ankra2 34 35 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | CG5846 35 |
|
OneToMany |
- Species where no ortholog for ANKRA2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for ANKRA2 Gene
(1) SIMAP similar genes for ANKRA2 Gene using alignment to 2 proteins:
Variants for ANKRA2 Gene
| SNP ID | Clin | Chr 05 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000120750 | -- | 73,564,025(+) | CTCCA(G/T)CACTC | intron-variant, upstream-variant-2KB | |
| rs1000309739 | -- | 73,555,995(+) | TGGGA(A/G)GATCA | intron-variant | |
| rs1000316267 | -- | 73,565,931(+) | GCTCC(C/G)ATTGA | intron-variant, upstream-variant-2KB, utr-variant-5-prime | |
| rs1000329196 | -- | 73,566,316(+) | GGTGC(C/T)AGTCA | intron-variant, upstream-variant-2KB | |
| rs1000456824 | -- | 73,563,693(+) | AGATA(C/T)ATTAT | intron-variant |
Residual Variation Intolerance Score:
20.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.57;
12.37% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for ANKRA2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- ANKRA2
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANKRA2 Gene
Disorders for ANKRA2 Gene
Relevant External Links for ANKRA2
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- ANKRA2
No disorders were found for ANKRA2 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANKRA2 Gene
Publications for ANKRA2 Gene
- Ankyrin repeats of ANKRA2 recognize a PxLPxL motif on the 3M syndrome protein CCDC8. (PMID: 25752541) Nie J. … Yang X.J. (Structure 2015) 3 4 64
- Sequence-specific recognition of a PxLPxI/L motif by an ankyrin repeat tumbler lock. (PMID: 22649097) Xu C. … Min J. (Sci. Signal. 2012) 3 4 64
- Characterization of hNek6 interactome reveals an important role for its short N-terminal domain and colocalization with proteins at the centrosome. (PMID: 20873783) Vaz Meirelles G. … Kobarg J. (J. Proteome Res. 2010) 3 4 64
- Identification of the ankyrin repeat proteins ANKRA and RFXANK as novel partners of class IIa histone deacetylases. (PMID: 15964851) Wang A.H. … Yang X.J. (J. Biol. Chem. 2005) 3 22 64
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
Products for ANKRA2 Gene
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- ProSpec Recombinant Proteins for ANKRA2
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- antibodies-online Antibodies for ANKRA2: See all 33
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- ViGene Biosciences adenoviral particle packaged cDNA for ANKRA2 gene
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- Cyagen custom Knockout/knockin (KOKI) mouse models for ANKRA2
- VectorBuilder custom plasmid, inducible vectors for ANKRA2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ANKRA2
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for ANKRA2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
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- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
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- (112) GeneTex
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- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer