ANKRA2 Gene
protein-coding GIFtS: 49
GCID: GC05M072883
|
|
ankyrin repeat, family A (RFXANK-like), 2
| |
Aliases
for ANKRA2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Ankyrin Repeat, Family A (RFXANK-Like), 21 2 | | ANKRA2 3 5 | | RFXANK-Like Protein 22 3 | | Ankyrin Repeat Family A Protein 22 |
Export aliases for ANKRA2 gene to outside databasesPrevious GC identifers: GC05M071653 GC05M073081 GC05M072886 GC05M072932 GC05M068053 |
Summaries
for ANKRA2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ANRA2_HUMAN, Q9H9E1Function: May facilitate endocytosis by linking megalin to components of the cytoskeleton or endocytic machinery
|
Genomic Views
for ANKRA2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000005.9 NC_018916.1 NT_006713.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ANKRA2 gene promoter:
ATF-2 POU3F2 (N-Oct-5a) POU3F2 (N-Oct-5b) POU3F2 POU2F1 POU2F1b POU2F1a c-Jun POU2F1c
Other transcription factors
Search SABiosciences Chromatin IP Primers for ANKRA2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ANKRA2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 5q12-q13 Ensembl cytogenetic band: 5q13.2 HGNC cytogenetic band: 5q12-q13ANKRA2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 5 GeneLoc Exon Structure GeneLoc location for GC05M072883: view genomic region
(about GC identifiers)
Start:
|
72,848,025 bp from pter |
End:
|
72,861,511 bp from pter |
Size:
|
13,487 bases |
Orientation:
|
minus strand |
|
Proteins
for ANKRA2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ANRA2_HUMAN, Q9H9E1 (See
protein sequence)Recommended Name: Ankyrin repeat family A protein 2 Size: 313 amino acids; 34272 Da
Subunit: Interacts with the cytoplasmic tail of LRP2/megalin, HDAC4, HDAC5, and HDAC9, all these interactions occur viathe recognition of a PxLPxI/L motif. Interacts with AHRR (By similarity). Interacts with NEK6
Subcellular location: Cytoplasm, cytoskeleton (By similarity). Membrane; Peripheral membrane protein (By similarity)
4 PDB 3D structures from  and Proteopedia  for ANKRA2:3SO8 (3D)
3V2O (3D)
3V2X (3D)
3V31 (3D)
Explore the universe of human proteins at neXtProt for ANKRA2: NX_Q9H9E1
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9H9E1
ANKRA2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_075526.1
ENSEMBL proteins: ENSP00000296785 ENSP00000422643
Human Recombinant Protein Products:
Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table
ANKRA2 for ontologies About GeneDecksing
ANKRA2 Antibody Products:
Assay Products for ANKRA2: |
Protein
Domains /
Families
for ANKRA2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ANKRA2 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9H9E1ProtoNet protein and cluster: Q9H9E1 1 Blocks protein family: IPB002110 Ankyrin repeat signature
UniProtKB/Swiss-Prot: ANRA2_HUMAN, Q9H9E1Domain: The three central ANK repeats mediate binding to the PxLPxI/L motif of interactorsSimilarity: Contains 5 ANK repeats |
Function
for ANKRA2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ANRA2_HUMAN, Q9H9E1Function: May facilitate endocytosis by linking megalin to components of the cytoskeleton or endocytic machinery
Clone
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANKRA2 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
ANKRA2 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for ANKRA2:
|
Pathways & Interactions
for ANKRA2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Signaling events mediated by HDAC Class II | |
1  BioSystems Pathway for ANKRA2
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ANKRA2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 11)
5/12 Interacting proteins for ANKRA2 (Q9H9E13 ENSP000002967854) via UniProtKB, MINT, STRING, and/or I2D (see all 12)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008150 | biological_process |
ND | -- |
ANKRA2 for ontologies About GeneDecksing
|
Drugs & Compounds
for ANKRA2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ANKRA2
Search CenterWatch for drugs/clinical trials and news about ANKRA2 / ANRA2
|
Transcripts
for ANKRA2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ANKRA2 gene: NM_023039.4 Unigene Cluster for ANKRA2: Ankyrin repeat, family A (RFXANK-like), 2 Hs.239154 [show with all ESTs]Unigene Representative Sequence: NM_0230398 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000296785(uc003kcu.2) ENST00000505301 ENST00000515249 ENST00000504641
ENST00000506130 ENST00000515804 ENST00000514916 ENST00000509433
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ANKRA2 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ANKRA2 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ANKRA2 (NM_023039) | | | DNA2.0 Custom Codon Optimized Gene
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Additional cDNA sequence: AF251051.1 AF314032.1 AK022876.1 BC012917.1 9 DOTS entries: DT.443440 DT.91748791 DT.100775278 DT.95083899 DT.99998858 DT.100772638 DT.91674771 DT.95083883 DT.100662456 24/153 AceView cDNA sequences (see all 153): CR600986 BX339562 BF447929 AL546663 BQ222914 BF446446 AI632886 AU280004 AA442702 CA773710 CR604361 NM_023039 BI908680 BG054552 AK022876 AW771301 AW770054 BM711293 BX488870 BI761919 AF251051 BC012917 AI371756 BM701933
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for ANKRA2 About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | ^ | 7 | ^ | 8a | · | 8b | · | 8c | · | 8d | · | 8e |
|---|
|
| SP1: | | | | | | | | | - | | | | | | - | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | - | | | | | | - | | | | | | - | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | |
| SP4: | | | - | | | | | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for ANKRA2
|
Expression
for ANKRA2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ANKRA2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TAAATTTTTA
About this image
See ANKRA2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ANKRA2
SOURCE GeneReport for Unigene cluster: Hs.239154
SABiosciences Expression via Pathway-Focused PCR Array including ANKRA2: | Lipoprotein Signaling & Cholesterol Metabolism in human mouse rat |
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ANKRA2
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANKRA2 |
Orthologs
for ANKRA2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for ANKRA2 gene from 6/16 species (see all 16) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Ankra21 , 5 |
ankyrin repeat, family A (RFXANK-like), 21, 5 |
88.78(n)1
95.19(a)1 |
|
13 (51.89 cM)5
685581 NM_023472.11 NP_075961.11
982631585 |
chicken
(Gallus gallus) |
Aves |
ANKRA21 |
ankyrin repeat, family A (RFXANK-like), 2 |
80.94(n)
92.65(a) |
|
426153 NM_001006565.1 NP_001006565.1 |
lizard
(Anolis carolinensis) |
Reptilia |
ANKRA26 |
-- |
92(a) |
1 ↔ 1 |
2(15882969-15888935) |
tropical clawed frog
(Xenopus tropicalis) |
Amphibia |
Str.39152 |
Transcribed sequence with moderate similarity to protein more |
82.25(n) |
|
BX722582.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
BC053275.12 |
-- |
76.6(n) |
|
BC053275.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG58466 |
-- |
30(a) |
1 → many |
2L(9956148-9957019) |
ENSEMBL Gene Tree for ANKRA2 (if available)
TreeFam Gene Tree for ANKRA2 (if available) |
Paralogs
for ANKRA2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ANKRA2 gene
- RFXANK2
1 SIMAP similar gene for ANKRA2 using alignment to 2 protein entries: ANRA2_HUMAN (see all proteins):RFXANK
ANKRA2 for paralogs About GeneDecksing
|
Genomic Variants
for ANKRA2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 5 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ANKRA2 (72848025 - 72861511 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ANKRA2: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ANKRA2 |
|
Disorders
/ Diseases
for ANKRA2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ANKRA2 for disorders About GeneDecksing
OMIM gene information: 605787
OMIM disorders: --
1  disease for ANKRA2: About MalaCardscholesterol
Export disorders for ANKRA2 gene to outside databases
|
Publications
for ANKRA2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ANKRA2 gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with ANKRA2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Sequence-specific recognition of a PxLPxI/L motif by a n ankyrin repeat tumbler lock. (PubMed id 22649097)1, 2 Xu C....Min J. (2012)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Assignment of ankyrin repeat, family A (RFXANK-like) 2 (ANKRA2) to human chromosome 5q12-->q13 by radiation hybrid mapping and somatic cell hybrid PCR. (PubMed id 10965114)1, 3 Rader K....Arden K.C. (2000)
- Characterization of ANKRA, a novel ankyrin repeat protein that interacts with the cytoplasmic domain of megalin. (PubMed id 11095640)1, 2 Rader K.... Farquhar M.G. (2000)
- Identification of the ankyrin repeat proteins ANKRA and RFXANK as novel partners of class IIa histone deacetylases. (PubMed id 15964851)1, 9 Wang A.H....Yang X.J. (2005)
- Functional dissection of lysine deacetylases reveals t hat HDAC1 and p300 regulate AMPK. (PubMed id 22318606)1 Lin Y.Y....Boeke J.D. (2012)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- Characterization of hNek6 interactome reveals an impo rtant role for its short N-terminal domain and colocalization with proteins at the centrosome. (PubMed id 20873783)2 Vaz Meirelles G....Kobarg J. (2010)
- Molecular mechanism of transcriptional repression of AhR repressor involving ANKRA2, HDAC4, and HDAC5. (PubMed id 17949687)1 Oshima M....Fujii-Kuriyama Y. (2007)
|
External Searches for ANKRA2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ANKRA2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ANKRA2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ANKRA2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ANKRA2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ANKRA2 gene:
Search GeneIP for patents involving ANKRA2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ANKRA2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANKRA2 |
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