Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ANKMY2 Gene

Aliases for ANKMY2 Gene

  • Ankyrin Repeat And MYND Domain Containing 2 2 3
  • Ankyrin Repeat And MYND Domain-Containing Protein 2 3
  • ZMYND20 3

External Ids for ANKMY2 Gene

Previous GeneCards Identifiers for ANKMY2 Gene

  • GC07M016384
  • GC07M016412
  • GC07M016606
  • GC07M016639
  • GC07M016526

Summaries for ANKMY2 Gene

GeneCards Summary for ANKMY2 Gene

ANKMY2 (Ankyrin Repeat And MYND Domain Containing 2) is a Protein Coding gene.

UniProtKB/Swiss-Prot for ANKMY2 Gene

  • May be involved in the trafficking of signaling proteins to the cilia.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANKMY2 Gene

Genomics for ANKMY2 Gene

Regulatory Elements for ANKMY2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ANKMY2 Gene

Start:
16,599,776 bp from pter
End:
16,645,817 bp from pter
Size:
46,042 bases
Orientation:
Minus strand

Genomic View for ANKMY2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ANKMY2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANKMY2 Gene

Proteins for ANKMY2 Gene

  • Protein details for ANKMY2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IV38-ANKY2_HUMAN
    Recommended name:
    Ankyrin repeat and MYND domain-containing protein 2
    Protein Accession:
    Q8IV38
    Secondary Accessions:
    • A4D124
    • Q659G1
    • Q96BL3

    Protein attributes for ANKMY2 Gene

    Size:
    441 amino acids
    Molecular mass:
    49299 Da
    Quaternary structure:
    • Interacts with the retinal-specific guanylyl cyclase GC1.

neXtProt entry for ANKMY2 Gene

Proteomics data for ANKMY2 Gene at MOPED

Post-translational modifications for ANKMY2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ANKMY2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ANKMY2 Gene

Domains for ANKMY2 Gene

Gene Families for ANKMY2 Gene

HGNC:
  • ANKRD :Ankyrin repeat domain containing
  • ZMYND :Zinc fingers, MYND-type

Protein Domains for ANKMY2 Gene

Suggested Antigen Peptide Sequences for ANKMY2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IV38

UniProtKB/Swiss-Prot:

ANKY2_HUMAN :
  • Q8IV38
Similarity:
  • Contains 3 ANK repeats.
  • Contains 1 MYND-type zinc finger.
genes like me logo Genes that share domains with ANKMY2: view

Function for ANKMY2 Gene

Molecular function for ANKMY2 Gene

UniProtKB/Swiss-Prot Function: May be involved in the trafficking of signaling proteins to the cilia.

Gene Ontology (GO) - Molecular Function for ANKMY2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ANKMY2: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ANKMY2 Gene

Localization for ANKMY2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ANKMY2 Gene

Cell projection, cilium.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ANKMY2 Gene COMPARTMENTS Subcellular localization image for ANKMY2 gene
Compartment Confidence
cytosol 2
extracellular 2
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for ANKMY2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005929 cilium IEA --
genes like me logo Genes that share ontologies with ANKMY2: view

Pathways for ANKMY2 Gene

SuperPathways for ANKMY2 Gene

No Data Available

Interacting Proteins for ANKMY2 Gene

Gene Ontology (GO) - Biological Process for ANKMY2 Gene

None

No data available for Pathways by source for ANKMY2 Gene

Transcripts for ANKMY2 Gene

Unigene Clusters for ANKMY2 Gene

Ankyrin repeat and MYND domain containing 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ANKMY2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ANKMY2 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13
SP1: - - - -
SP2: - - - - -
SP3: - -
SP4:
SP5: -
SP6: -

Relevant External Links for ANKMY2 Gene

GeneLoc Exon Structure for
ANKMY2
ECgene alternative splicing isoforms for
ANKMY2

Expression for ANKMY2 Gene

mRNA expression in normal human tissues for ANKMY2 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ANKMY2 Gene

SOURCE GeneReport for Unigene cluster for ANKMY2 Gene Hs.157378

genes like me logo Genes that share expressions with ANKMY2: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ANKMY2 Gene

Orthologs for ANKMY2 Gene

This gene was present in the common ancestor of animals.

Orthologs for ANKMY2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ANKMY2 35
  • 99.55 (n)
  • 99.32 (a)
ANKMY2 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ANKMY2 35
  • 91.53 (n)
  • 93.42 (a)
ANKMY2 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ANKMY2 35
  • 92.52 (n)
  • 94.1 (a)
ANKMY2 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ankmy2 35
  • 84.92 (n)
  • 88.86 (a)
Ankmy2 16
Ankmy2 36
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ANKMY2 36
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ANKMY2 36
  • 78 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ankmy2 35
  • 83.97 (n)
  • 87.79 (a)
chicken
(Gallus gallus)
Aves ANKMY2 35
  • 77.2 (n)
  • 82.59 (a)
ANKMY2 36
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ANKMY2 36
  • 72 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.26108 35
tropical clawed frog
(Silurana tropicalis)
Amphibia ankmy2 35
  • 73.83 (n)
  • 75.5 (a)
zebrafish
(Danio rerio)
Actinopterygii ankmy2a 35
  • 70.9 (n)
  • 76.72 (a)
ankmy2a 36
  • 70 (a)
OneToMany
ankmy2b 36
  • 58 (a)
OneToMany
wufi46e08 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004933 35
  • 49.71 (n)
  • 42.44 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG8003 35
  • 50.91 (n)
  • 42.35 (a)
CG8003 36
  • 37 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea daf-25 35
  • 46.67 (n)
  • 34.63 (a)
daf-25 36
  • 30 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 40 (a)
OneToOne
Species with no ortholog for ANKMY2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ANKMY2 Gene

ENSEMBL:
Gene Tree for ANKMY2 (if available)
TreeFam:
Gene Tree for ANKMY2 (if available)

Paralogs for ANKMY2 Gene

Selected SIMAP similar genes for ANKMY2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ANKMY2: view

No data available for Paralogs for ANKMY2 Gene

Variants for ANKMY2 Gene

Sequence variations from dbSNP and Humsavar for ANKMY2 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs7156 -- 16,599,990(-) CATAC(G/T)CCACC utr-variant-3-prime
rs476489 -- 16,603,370(-) TACCT(C/T)GACTC intron-variant
rs479202 -- 16,611,602(-) CCCCT(A/G)TTCTC intron-variant
rs481026 -- 16,611,790(+) TCTAC(A/C)CTGTT intron-variant
rs511938 -- 16,612,853(-) AATAA(A/C)AAGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ANKMY2 Gene

Variant ID Type Subtype PubMed ID
nsv830912 CNV Gain 17160897
nsv887758 CNV Gain 21882294
nsv522819 CNV Loss 19592680
nsv887759 CNV Gain 21882294
esv2734056 CNV Deletion 23290073
esv2174786 CNV Deletion 18987734
esv2657728 CNV Deletion 23128226

Relevant External Links for ANKMY2 Gene

HapMap Linkage Disequilibrium report
ANKMY2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANKMY2 Gene

Disorders for ANKMY2 Gene

No disorders were found for ANKMY2 Gene.

No data available for UniProtKB/Swiss-Prot for ANKMY2 Gene

Publications for ANKMY2 Gene

  1. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Role of the ANKMY2-FKBP38 axis in regulation of the Sonic hedgehog (Shh) signaling pathway. (PMID: 25077969) Saita S. … Nakayama K.I. (J. Biol. Chem. 2014) 2 3
  4. The full-ORF clone resource of the German cDNA consortium. (PMID: 17974005) Bechtel S. … Schupp I. (BMC Genomics 2007) 4
  5. Initial characterization of the human central proteome. (PMID: 21269460) Burkard T.R. … Colinge J. (BMC Syst. Biol. 2011) 4

Products for ANKMY2 Gene

Sources for ANKMY2 Gene

Back to Top

Content