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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ANKMY1 Gene

protein-coding   GIFtS: 45
GCID: GC02M241438

ankyrin repeat and MYND domain containing 1

  Search for ANKMY1
in our new
 Human Malady Compendium 
Biological research products
for ANKMY1
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Ankyrin Repeat And MYND Domain Containing 11 2     FLJ204991
ZMYND131 2 3     Ankyrin Repeat And MYND Domain-Containing Protein 12
Testis-Specific Ankyrin-Like Protein 12 3     Testis Specific Ankyrin-Like Protein 12
Zinc Finger MYND Domain-Containing Protein 132 3     TSAL13

External Ids:    HGNC: 209871   Entrez Gene: 512812   Ensembl: ENSG000001445047   UniProtKB: Q9P2S63   

Export aliases for ANKMY1 gene to outside databases

Previous GC identifers: GC02M241739 GC02M241138 GC02M233174


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

  --

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.1  NT_005416.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ANKMY1 gene promoter:
         COUP-TF1   COUP-TF   COUP   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ANKMY1 promoter sequence
   Search SABiosciences Chromatin IP Primers for ANKMY1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ANKMY1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q37.3   Ensembl cytogenetic band:  2q37.3   HGNC cytogenetic band: 2q37.3

ANKMY1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ANKMY1 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M241438:  view genomic region     (about GC identifiers)

Start:
241,418,839 bp from pter      End:
241,508,626 bp from pter
Size:
89,788 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ANKY1_HUMAN, Q9P2S6 (See protein sequence)
Recommended Name: Ankyrin repeat and MYND domain-containing protein 1  
Size: 941 amino acids; 105516 Da
Secondary accessions: B2RB78 Q4ZFV3 Q8IYX5 Q8NDK5 Q9H0V8 Q9NX10
Alternative splicing: 4 isoforms:  Q9P2S6-1   Q9P2S6-2   Q9P2S6-3   Q9P2S6-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ANKMY1: NX_Q9P2S6

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9P2S6

  • ANKMY1 Protein expression data from MOPED and PaxDb:    About this image 
    ANKMY1 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_057636.2  NP_060314.2  

    ENSEMBL proteins: 
     ENSP00000362415   ENSP00000384555   ENSP00000272972   ENSP00000355097   ENSP00000383968  
     ENSP00000385887   ENSP00000385267   ENSP00000375848   ENSP00000385635   ENSP00000385145  
     ENSP00000405938   ENSP00000404095   ENSP00000407015   ENSP00000412094   ENSP00000404337  
     ENSP00000375847   ENSP00000362417   ENSP00000444707  

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    Uscn Proteins for ANKMY1


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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ANKMY1 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR002893 Znf_MYND
     IPR020683 Ankyrin_rpt-contain_dom
     IPR003409 MORN
     IPR002110 Ankyrin_rpt

    Graphical View of Domain Structure for InterPro Entry Q9P2S6

    ProtoNet protein and cluster: Q9P2S6

    1 Blocks protein family: IPB002893 Zn-finger

    UniProtKB/Swiss-Prot: ANKY1_HUMAN, Q9P2S6
    Similarity: Contains 7 ANK repeats
    Similarity: Contains 3 MORN repeats
    Similarity: Contains 1 MYND-type zinc finger


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008270zinc ion binding IEA--
         
    ANKMY1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ANKMY1:
     Increased cell number in G2M,  

    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for ANKMY1 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANKMY1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ANKMY1

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ANKMY1
    Search CenterWatch for drugs/clinical trials and news about ANKMY1 / ANKY1 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ANKMY1 gene (2 alternative transcripts): 
    NM_016552.2  NM_017844.2  

    Unigene Cluster for ANKMY1:

    Ankyrin repeat and MYND domain containing 1
    Hs.656615  [show with all ESTs]
    Unigene Representative Sequence: AK126637
    18/26 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 26):
    ENST00000373318 ENST00000406958(uc002vzb.1) ENST00000272972(uc002vyz.1)
    ENST00000361678(uc002vza.1) ENST00000403283(uc002vzd.1) ENST00000401804
    ENST00000407275 ENST00000489677 ENST00000391988 ENST00000405523 ENST00000405002(uc002vze.3)
    ENST00000480230 ENST00000484526(uc010fze.2) ENST00000459901 ENST00000496300
    ENST00000441168 ENST00000443318 ENST00000462004

    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidANKMY1 3' UTR sequence
    Inhib. RNA
    Products:
         
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ANKMY1
    OriGene shRNA RFP: ANKMY1
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    Sirion Biotech Custom design and validation of potent shRNA sequences against ANKMY1 
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ANKMY1
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    Additional cDNA sequence: 

    AB034636.1 AK000506.1 AK056511.2 AK124879.1 AK126637.1 AK225534.1 AK296714.1 AK314534.1 
    AL136618.1 AL833866.1 BC033495.1 BC036111.1 BC073146.1 CR936600.1 CR936759.1 

    12 DOTS entries:

    DT.91678013  DT.40199576  DT.99935140  DT.100705602  DT.100642715  DT.120929792  DT.100722470  DT.97822441 
    DT.120929821  DT.102830111  DT.75101241  DT.91681550 

    2 AceView cDNA sequences:

    NM_016552 NM_017844 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for ANKMY1 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19
    SP1:                          -                       -                             -           -                                                         
    SP2:                                            -     -     -                       -           -           -     -                                       
    SP3:                                            -     -     -                       -           -                 -     -                                 
    SP4:                                            -     -     -                       -                                                                     
    SP5:                                                  -     -                                                                                             


    ECgene alternative splicing isoforms for ANKMY1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ANKMY1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CTTTGTAGCA
    ANKMY1 Expression
    About this image
    See ANKMY1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ANKMY1

    SOURCE GeneReport for Unigene cluster: Hs.656615
        SABiosciences Custom PCR Arrays for ANKMY1

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANKMY1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for ANKMY1 gene from 3/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves --
    --
    Uncharacterized protein
    49(a)
    49(a)
    many → 1
    many → 1
    17(647687-650868)
    17(624991-639612)
    lizard
    (Anolis carolinensis)
    Reptilia ANKMY16
    --
    46(a)
    1 ↔ 1
    3(29823654-29861960)
    zebrafish
    (Danio rerio)
    Actinopterygii si:rp71-69p9.26
    si:rp71-69p9.2
    33(a)
    1 ↔ 1
    22(15697633-15715344)
            Species with no ortholog for ANKMY1

    ENSEMBL Gene Tree for ANKMY1 (if available)
    TreeFam Gene Tree for ANKMY1 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1424 NCBI SNPs in ANKMY1 are shown (see all 1424    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1432619841,2
    --241418339(+) CTGTCA/GTCCTT 2 -- int10--------
    rs1891124961,2
    --241418376(+) CTTCCC/TCTGCC 2 -- int10--------
    rs64373461,2
    C,F,A,H--241418554(+) CCGCAG/AACCCC 2 -- int116Minor allele frequency- A:0.15NA WA CSA EA 519
    rs1482996141,2
    --241418563(+) CCAGTA/GGGAGC 2 -- int10--------
    rs1920416421,2
    --241418611(+) GCTGCC/TGCGGG 2 -- int10--------
    rs116949381,2
    C,F,H--241418613(+) TGCCGC/TGGGCT 2 -- int13Minor allele frequency- T:0.10NA WA 242
    rs731040811,2
    C--241418717(+) CGTCCG/ATCAGG 2 -- int11Minor allele frequency- A:0.50WA 2
    rs1137282841,2
    F--241418807(+) CTGGGG/ACTTTG 2 -- int11Minor allele frequency- A:0.50CSA 4
    rs1844499591,2
    --241418893(+) AGACAC/TTGCTA 2 -- ut310--------
    rs40730201,2
    C--241418924(-) GGCATT/GTCTGC 2 -- ut31 ese31Minor allele frequency- G:0.00NA 2

    HapMap Linkage Disequilibrium report for ANKMY1 (241418839 - 241508626 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 7 variations for ANKMY1
         6 CNVs: 31022 2428 58974 50436 3409 1609
         1 Inversion: 59768

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ANKMY1 for disorders           About MalaCards

    ANKMY1 for disorders           About GeneDecksing

    Human Genome Epidemiology (HuGE) Navigator: ANKMY1 (2 documents)

    Export disorders for ANKMY1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ANKMY1 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ANKMY1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. New gene functions in megakaryopoiesis and platelet fo rmation. (PubMed id 22139419)1 Gieger C....Soranzo N. (2011)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    5. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
    6. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W....Wilson R.K. (2005)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    8. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)2 Wiemann S.... Poustka A. (2001)
    9. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
    10. Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PubMed id 8125298)1 Maruyama K. and Sugano S. (1994)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51281 HGNC: 20987 AceView: ANKMY1 Ensembl:ENSG00000144504 euGenes: HUgn51281
    ECgene: ANKMY1 H-InvDB: ANKMY1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ANKMY1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ANKMY1 gene:
    Search GeneIP for patents involving ANKMY1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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