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ANKLE2 Gene

protein-coding   GIFtS: 50
GCID: GC12M133302

Ankyrin Repeat And LEM Domain Containing 2

(Previous name: KIAA0692)
(Previous symbol: KIAA0692)
  See ANKLE2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ankyrin Repeat And LEM Domain Containing 21 2     LEMD72
KIAA06921 2 3     Lem42
LEM Domain Containing 71 2     Ankyrin Repeat And LEM Domain-Containing Protein 22
LEM Domain-Containing Protein 42 3     LEM43

External Ids:    HGNC: 291011   Entrez Gene: 231412   Ensembl: ENSG000001769157   UniProtKB: Q86XL33   

Export aliases for ANKLE2 gene to outside databases

Previous GC identifers: GC12M131812 GC12M130081


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ANKLE2 Gene:
This gene encodes a member of the LEM family of inner nuclear membrane proteins. The encoded protein functions as
a mitotic regulator through postmitotic formation of the nuclear envelope. Mutations in this gene cause
morphology defects in the nuclear envelope and BAF hyperphosphorylation. (provided by RefSeq, Mar 2014)

GeneCards Summary for ANKLE2 Gene:
ANKLE2 (ankyrin repeat and LEM domain containing 2) is a protein-coding gene. Diseases associated with ANKLE2 include scurvy, and villonodular synovitis. GO annotations related to this gene include protein phosphatase 2A binding and protein phosphatase type 2A regulator activity.

UniProtKB/Swiss-Prot: ANKL2_HUMAN, Q86XL3
Function: Involved in mitotic nuclear envelope reassembly by promoting dephosphorylation of BAF/BANF1 during
mitotic exit. Coordinates the control of BAF/BANF1 dephosphorylation by inhibiting VRK1 kinase and promoting
dephosphorylation of BAF/BANF1 by protein phosphatase 2A (PP2A), thereby facilitating nuclear envelope assembly.
It is unclear whether it acts as a real PP2A regulatory subunit or whether it is involved in recruitment of the
PP2A complex




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NT_024477.15  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ANKLE2 gene promoter:
         HFH-3   NRSF form 1   MIF-1   Ik-3   NRSF form 2   NF-AT   FOXL1   FOXI1   HFH-1   NF-AT1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for ANKLE2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ANKLE2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.33   Ensembl cytogenetic band:  12q24.33   HGNC cytogenetic band: 12q24.33

ANKLE2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ANKLE2 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M133302:  view genomic region     (about GC identifiers)

Start:
133,302,254 bp from pter      End:
133,338,474 bp from pter
Size:
36,221 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ANKL2_HUMAN, Q86XL3 (See protein sequence)
Recommended Name: Ankyrin repeat and LEM domain-containing protein 2  
Size: 938 amino acids; 104114 Da
Subunit: Interacts with BAF/BANF1. Interacts with protein phosphatase 2A (PP2A) components PPP2C (PPP2CA or
PPP2CB) and PPP2R1A
Sequence caution: Sequence=BAG51259.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: A8KAG3 B3KN97 B3KSF8 O75176 Q6P6A5 Q8TAZ9 Q96DH4
Alternative splicing: 3 isoforms:  Q86XL3-1   Q86XL3-2   Q86XL3-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ANKLE2: NX_Q86XL3

Explore proteomics data for ANKLE2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys90, Lys394
  • Modification sites at PhosphoSitePlus

  • See ANKLE2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_055929.1  
    ENSEMBL proteins: 
     ENSP00000446268   ENSP00000350686   ENSP00000437807   ENSP00000438551   ENSP00000445760  
     ENSP00000437585   ENSP00000438515   ENSP00000445718   ENSP00000337651  
    Reactome Protein details: Q86XL3

    ANKLE2 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ANKRD: Ankyrin repeat domain containing

    5 InterPro protein domains:
     IPR003887 LEM_dom
     IPR011015 LEM/LEM-like_dom
     IPR002110 Ankyrin_rpt
     IPR020683 Ankyrin_rpt-contain_dom
     IPR011320 RNase_H1_N

    Graphical View of Domain Structure for InterPro Entry Q86XL3

    ProtoNet protein and cluster: Q86XL3

    2 Blocks protein domains:
    IPB002110 Ankyrin repeat signature
    IPB011015 LEM-like fold


    UniProtKB/Swiss-Prot: ANKL2_HUMAN, Q86XL3
    Similarity: Belongs to the ANKLE2 family
    Similarity: Contains 1 ANK repeat
    Similarity: Contains 1 LEM domain


    Find genes that share domains with ANKLE2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ANKL2_HUMAN, Q86XL3
    Function: Involved in mitotic nuclear envelope reassembly by promoting dephosphorylation of BAF/BANF1 during
    mitotic exit. Coordinates the control of BAF/BANF1 dephosphorylation by inhibiting VRK1 kinase and promoting
    dephosphorylation of BAF/BANF1 by protein phosphatase 2A (PP2A), thereby facilitating nuclear envelope assembly.
    It is unclear whether it acts as a real PP2A regulatory subunit or whether it is involved in recruitment of the
    PP2A complex

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
    GO:0008601protein phosphatase type 2A regulator activity TAS--
    GO:0051721protein phosphatase 2A binding IDA--
         
    Find genes that share ontologies with ANKLE2           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for ANKLE2

    miRNA
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    miRTarBase miRNAs that target ANKLE2:
    hsa-mir-16-5p (MIRT031684), hsa-mir-92a-3p (MIRT049020)

    Block miRNA regulation of human, mouse, rat ANKLE2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ANKLE2 (see all 13):
    hsa-miR-548p hsa-miR-200a hsa-miR-4282 hsa-miR-570 hsa-miR-141 hsa-miR-124 hsa-miR-1303 hsa-miR-29a*
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ANKL2_HUMAN, Q86XL3: Endoplasmic reticulum membrane; Single-pass type III membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    cytosol3
    nucleus2

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005789endoplasmic reticulum membrane TAS--
    GO:0030176integral component of endoplasmic reticulum membrane IDA--

    Find genes that share ontologies with ANKLE2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ANKLE2 About    
    See pathways by source

    SuperPathContained pathways About
    1Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    M Phase0.62
    Cell Cycle0.90
    2Mitotic Metaphase and Anaphase
    Mitotic Anaphase0.94
    Mitotic Metaphase and Anaphase0.93
    3Nuclear Envelope Reassembly
    Nuclear Envelope Reassembly
    Initiation of Nuclear Envelope Reformation0.00


    Find genes that share SuperPaths with ANKLE2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for ANKLE2
        Initiation of Nuclear Envelope Reformation


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ANKLE2
    Interactions:

        Search GeneGlobe Interaction Network for ANKLE2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    Selected Interacting proteins for ANKLE2 (Q86XL31, 3 ENSP000003506864) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PPP2CBP627143, ENSP000002211384I2D: score=1 STRING: ENSP00000221138
    PPP2R1AP301533, ENSP000003248044I2D: score=1 STRING: ENSP00000324804
    PPP2CAP677753, ENSP000004184474I2D: score=1 STRING: ENSP00000418447
    MAPK13O152643, ENSP000002112874I2D: score=2 STRING: ENSP00000211287
    ZFYVE9O954053I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000278mitotic cell cycle TAS--
    GO:0007067mitosis IEA--
    GO:0007084mitotic nuclear envelope reassembly TAS--
    GO:0035307positive regulation of protein dephosphorylation IDA--
    GO:0042326negative regulation of phosphorylation IDA--

    Find genes that share ontologies with ANKLE2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for ANKLE2 (ANKL2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ANKLE2 gene: 
    NM_015114.2  

    Unigene Cluster for ANKLE2:

    Ankyrin repeat and LEM domain containing 2
    Hs.654628  [show with all ESTs]
    Unigene Representative Sequence: NM_015114
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000539605 ENST00000357997(uc009zyw.1 uc001ukx.2) ENST00000542282
    ENST00000542657 ENST00000542374 ENST00000538766 ENST00000505031 ENST00000439231
    ENST00000538591 ENST00000535036 ENST00000545623 ENST00000538637 ENST00000546061
    ENST00000337516(uc001uky.3)
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    Selected qRT-PCR Assays for microRNAs that regulate ANKLE2 (see all 13):
    hsa-miR-548p hsa-miR-200a hsa-miR-4282 hsa-miR-570 hsa-miR-141 hsa-miR-124 hsa-miR-1303 hsa-miR-29a*
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    Additional mRNA sequence: 

    AB014592.1 AK024061.1 AK025933.1 AK293028.1 BC001530.2 BC025347.1 BC043157.1 BC062373.1 
    BC082962.1 

    18 DOTS entries:

    DT.316056  DT.95224250  DT.95224259  DT.100731280  DT.121185683  DT.121185757  DT.100788149  DT.100788153 
    DT.91756153  DT.95114491  DT.102833243  DT.121185719  DT.40273805  DT.100788154  DT.121185640  DT.121185751 
    DT.92414992  DT.95224278 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ANKLE2 (see all 14)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b ^ 13a · 13b · 13c ^ 14a · 14b · 14c ^ 15a ·
    SP1:        -     -                                                                 -     -                 -                       -     -                 -   
    SP2:                                                                                -     -                 -                       -     -                     
    SP3:                                                                                      -                                                                     
    SP4:                                                                                      -                 -                                                   
    SP5:                                                                                                        -                       -     -                     

    ExUns: 15b ^ 16 ^ 17a · 17b ^ 18 ^ 19a · 19b ^ 20a · 20b · 20c
    SP1:  -     -                                                   
    SP2:                                                            
    SP3:                                                            
    SP4:                                                            
    SP5:  -     -                                                   


    ECgene alternative splicing isoforms for ANKLE2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ANKLE2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTATTCTAAA
    ANKLE2 Expression
    About this image

    ANKLE2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ANKLE2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.654628
        Custom PCR Arrays for ANKLE2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANKLE2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ANKLE2 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ankle21 , 5 ankyrin repeat and LEM domain containing 21, 5 75.97(n)1
    70.8(a)1
      5 (53.40 cM)5
    717821  NM_001253814.11  NP_001240743.11 
     1102310045 
    chicken
    (Gallus gallus)
    Aves ANKLE21 ankyrin repeat and LEM domain containing 2 66.78(n)
    63.16(a)
      416790  XM_415084.4  XP_415084.4 
    lizard
    (Anolis carolinensis)
    Reptilia ANKLE26
    ankyrin repeat and LEM domain containing 2
    57(a)
    1 ↔ 1
    GL343364.1(899884-910424)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia ankle21 ankyrin repeat and LEM domain containing 2 60.38(n)
    59.9(a)
      100380184  XM_004910572.1  XP_004910629.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ankle21 ankyrin repeat and LEM domain containing 2 58.49(n)
    56.19(a)
      559297  NM_001126395.2  NP_001119867.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta l(1)G02226
    lethal (1) G0222
    18(a)
    1 ↔ 1
    X(17465887-17473262)
    worm
    (Caenorhabditis elegans)
    Secernentea lem-46
    Protein LEM-4, isoform b (lem-4) mRNA, complete cd...
    30(a)
    1 ↔ 1
    IV(849273-854780) WBGene00021945


    ENSEMBL Gene Tree for ANKLE2 (if available)
    TreeFam Gene Tree for ANKLE2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ANKLE2 (see all 1259)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1153248541,2
    F--133301754(+) GGTACG/ACAGCA 1 -- int11Minor allele frequency- A:0.01WA 118
    rs792001901,2
    C--133301786(+) AACGAC/GCAGCA 1 -- int10--------
    rs763691611,2
    C,F--133301803(+) CCGGGC/TGCCTC 1 -- int12Minor allele frequency- T:0.04NA 122
    rs734871051,2
    C--133301869(+) CAACTG/TTTAAT 1 -- int12Minor allele frequency- T:0.25WA 120
    rs1825089421,2
    --133302136(+) AACCCA/CCCGGG 1 -- int10--------
    rs1879247881,2
    --133302149(+) ACACGA/GGAATG 1 -- int10--------
    rs1915624671,2
    --133302160(+) CCTCCA/GTTGGG 1 -- int10--------
    rs1839946051,2
    --133302219(+) TAAGAA/CCTGGG 1 -- int10--------
    rs1433217021,2
    --133302239(+) GCAGTC/GGTCCA 1 -- int10--------
    rs1872242031,2
    --133302243(+) TGGTCA/CACATA 1 -- int10--------

    HapMap Linkage Disequilibrium report for ANKLE2 (133302254 - 133338474 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for ANKLE2 (see all 15):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2747039CNV Deletion23290073
    esv1009039CNV Deletion20482838
    esv2747036CNV Deletion23290073
    esv2328159CNV Deletion18987734
    esv1331463CNV Deletion17803354
    esv2747037CNV Deletion23290073
    esv2747038CNV Deletion23290073
    esv2747035CNV Deletion23290073
    nsv53840CNV Insertion16902084
    nsv513379CNV Insertion21212237

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ANKLE2
    DNA2.0 Custom Variant and Variant Library Synthesis for ANKLE2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    3 diseases for ANKLE2:    
    About MalaCards
    scurvy    villonodular synovitis    pigmented villonodular synovitis

    2 diseases from the University of Copenhagen DISEASES database for ANKLE2:
    Pigmented villonodular synovitis     Scurvy

    Find genes that share disorders with ANKLE2           About GenesLikeMe


    Export disorders for ANKLE2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ANKLE2 gene, integrated from 10 sources (see all 22):
    (articles sorted by number of sources associating them with ANKLE2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9734811)1, 2, 3 Ishikawa K.... Ohara O. (DNA Res. 1998)
    2. Coordination of kinase and phosphatase activities by Lem4 enables nuclear envelope reassembly during mitosis. (PubMed id 22770216)1, 2 Asencio C.... Gorjanacz M. (Cell 2012)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Genome-wide association study of antibody response to smallpox vaccine. (PubMed id 22542470)1 Ovsyannikova I.G....Poland G.A. (Vaccine 2012)
    6. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    7. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    8. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    9. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)
    10. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (Sci. Signal. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23141 HGNC: 29101 Ensembl:ENSG00000176915 euGenes: HUgn23141 ECgene: ANKLE2
    H-InvDB: ANKLE2

    (According to HUGE)
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    HUGE: KIAA0692

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ANKLE2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ANKLE2 gene:
    Search GeneIP for patents involving ANKLE2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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