Aliases for ANKLE2 Gene
Aliases for ANKLE2 Gene
External Ids for ANKLE2 Gene
- HGNC: 29101
- Entrez Gene: 23141
- Ensembl: ENSG00000176915
- OMIM: 616062
- UniProtKB: Q86XL3
Previous HGNC Symbols for ANKLE2 Gene
- KIAA0692
Previous GeneCards Identifiers for ANKLE2 Gene
- GC12M131812
- GC12M133302
- GC12M130081
Summaries for ANKLE2 Gene
-
This gene encodes a member of the LEM family of inner nuclear membrane proteins. The encoded protein functions as a mitotic regulator through postmitotic formation of the nuclear envelope. Mutations in this gene cause morphology defects in the nuclear envelope and BAF hyperphosphorylation. [provided by RefSeq, Mar 2014]
GeneCards Summary for ANKLE2 Gene
ANKLE2 (Ankyrin Repeat And LEM Domain Containing 2) is a Protein Coding gene. Diseases associated with ANKLE2 include Microcephaly 16, Primary, Autosomal Recessive and Autosomal Recessive Primary Microcephaly. Among its related pathways are Mitotic Metaphase and Anaphase and Cell Cycle, Mitotic. GO annotations related to this gene include protein phosphatase 2A binding.
UniProtKB/Swiss-Prot for ANKLE2 Gene
-
Involved in mitotic nuclear envelope reassembly by promoting dephosphorylation of BAF/BANF1 during mitotic exit. Coordinates the control of BAF/BANF1 dephosphorylation by inhibiting VRK1 kinase and promoting dephosphorylation of BAF/BANF1 by protein phosphatase 2A (PP2A), thereby facilitating nuclear envelope assembly. It is unclear whether it acts as a real PP2A regulatory subunit or whether it is involved in recruitment of the PP2A complex. Involved in brain development (PubMed:25259927).
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANKLE2 Gene
Genomics for ANKLE2 Gene
Regulatory Elements for ANKLE2 Gene
Enhancers for ANKLE2 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH12G132765 | 1.4 | Ensembl ENCODE dbSUPER | 39.9 | -7.8 | -7806 | 9.2 | HDGF PKNOX1 ATF1 AGO1 WRNIP1 SIN3A ZNF2 ELK1 CBX5 REST | ANKLE2 GOLGA3 PGAM5 CHFR LOC101928530 P2RX2 RPS11P5 |
| GH12G132759 | 1.4 | ENCODE dbSUPER | 39.1 | +0.5 | 536 | 4.2 | HNRNPUL1 HDGF PKNOX1 ARNT WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 | ANKLE2 GOLGA3 POLE LRCOL1 ZNF84 LOC100419935 |
| GH12G132827 | 1.4 | ENCODE dbSUPER | 27.2 | -66.6 | -66595 | 2.6 | PKNOX1 MLX CREB3L1 ARNT AGO1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 | ANKLE2 ZNF140 ZNF26 EP400 ZNF891 PUS1 NOC4L ZNF605 CHFR P2RX2 |
| GH12G132837 | 1.3 | FANTOM5 Ensembl ENCODE dbSUPER | 27.1 | -76.3 | -76333 | 1.9 | POLR2A ZNF394 | ANKLE2 CHFR GC12M132836 GC12P132856 |
| GH12G132833 | 1.1 | Ensembl ENCODE dbSUPER | 27.2 | -73.3 | -73337 | 2.8 | TCF12 PKNOX1 NCOR1 TAL1 BHLHE40 MNT MYC CREM EP300 | ANKLE2 CHFR PUS1 ENSG00000250790 PIR43195 RNU6-327P |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around ANKLE2 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the ANKLE2 gene promoter:
Regulatory Element Products
Genomic Location for ANKLE2 Gene
- Chromosome:
- 12
- Start:
- 132,725,503 bp from pter
- End:
- 132,761,888 bp from pter
- Size:
- 36,386 bases
- Orientation:
- Minus strand
Genomic View for ANKLE2 Gene
Genes around ANKLE2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 12q24.33 by Ensembl
- 12q24.33 by Entrez Gene
- 12q24.33 by HGNC
ANKLE2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ANKLE2 Gene
Proteins for ANKLE2 Gene
-
Protein details for ANKLE2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q86XL3-ANKL2_HUMAN
- Recommended name:
- Ankyrin repeat and LEM domain-containing protein 2
- Protein Accession:
- Q86XL3
- A8KAG3
- B3KN97
- B3KSF8
- O75176
- Q6P6A5
- Q8TAZ9
- Q96DH4
Protein attributes for ANKLE2 Gene
- Size:
- 938 amino acids
- Molecular mass:
- 104114 Da
- Quaternary structure:
-
- Interacts with BAF/BANF1. Interacts with protein phosphatase 2A (PP2A) components PPP2C (PPP2CA or PPP2CB) and PPP2R1A.
- SequenceCaution:
-
- Sequence=BAG51259.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
Protein Expression for ANKLE2 Gene
Post-translational modifications for ANKLE2 Gene
Other Protein References for ANKLE2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for ANKLE2
-
Abcam antibodies for ANKLE2
- Invitrogen Antibodies for ANKLE2
- GeneTex ANKLE2 antibody for ANKLE2
-
Custom Antibody ServicesProSci Antibodies for ANKLE2
Protein Products
-
OriGene Purified Proteins for ANKLE2
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- Novus Biologicals proteins for ANKLE2
- Search GeneTex for Proteins for ANKLE2
Assay Products
No data available for DME Specific Peptides for ANKLE2 Gene
Domains & Families for ANKLE2 Gene
Gene Families for ANKLE2 Gene
Protein Domains for ANKLE2 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for ANKLE2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q86XL3- Family:
-
- Belongs to the ANKLE2 family.
Function for ANKLE2 Gene
Molecular function for ANKLE2 Gene
- UniProtKB/Swiss-Prot Function:
- Involved in mitotic nuclear envelope reassembly by promoting dephosphorylation of BAF/BANF1 during mitotic exit. Coordinates the control of BAF/BANF1 dephosphorylation by inhibiting VRK1 kinase and promoting dephosphorylation of BAF/BANF1 by protein phosphatase 2A (PP2A), thereby facilitating nuclear envelope assembly. It is unclear whether it acts as a real PP2A regulatory subunit or whether it is involved in recruitment of the PP2A complex. Involved in brain development (PubMed:25259927).
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 22770216 |
| GO:0019888 | protein phosphatase regulator activity | TAS | 22770216 |
| GO:0051721 | protein phosphatase 2A binding | IDA | 22770216 |
Phenotypes for ANKLE2 Gene
- GenomeRNAi human phenotypes for ANKLE2:
Animal Model Products
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- Cyagen custom Knockout/knockin (KOKI) mouse models for ANKLE2
-
-
ViGene Biosciences lentiviral particle packaged cDNA for ANKLE2 gene
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ViGene Biosciences ready-to-package AAV shRNAs for ANKLE2 gene
- Search ViGene Biosciences for ANKLE2
CRISPR Products
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OriGene CRISPR knockouts for ANKLE2
-
Santa Cruz Biotechnology (SCBT) CRISPR for ANKLE2
- GenScript: Design CRISPR guide RNA sequences for ANKLE2
miRNA for ANKLE2 Gene
- miRTarBase miRNAs that target ANKLE2
miRNA Products
- Search ViGene Biosciences for ANKLE2
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for ANKLE2
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
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Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for ANKLE2 Gene
Localization for ANKLE2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ANKLE2 Gene
- Endoplasmic reticulum membrane; Single-pass type III membrane protein.
| Compartment | Confidence |
|---|---|
| endoplasmic reticulum | 5 |
| nucleus | 2 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005783 | endoplasmic reticulum | IEA | -- |
| GO:0005789 | endoplasmic reticulum membrane | TAS | -- |
| GO:0016020 | membrane | IEA,IDA | 19946888 |
| GO:0016021 | integral component of membrane | IEA | -- |
| GO:0030176 | integral component of endoplasmic reticulum membrane | IDA | 22770216 |
Pathways & Interactions for ANKLE2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Cell Cycle, Mitotic |
.83
|
.60
|
| 2 | Nuclear Envelope Reassembly | ||
| 3 | Mitotic Metaphase and Anaphase |
.94
|
|
Pathways by source for ANKLE2 Gene
7 Reactome pathways for ANKLE2 Gene
Interacting Proteins for ANKLE2 Gene
Selected Interacting proteins:
Q86XL3-ANKL2_HUMAN
ENSP00000350686
for ANKLE2 Gene via
IID
UniProtKB
STRING
MINT
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007049 | cell cycle | IEA | -- |
| GO:0007067 | mitotic nuclear division | IEA | -- |
| GO:0007084 | mitotic nuclear envelope reassembly | TAS | -- |
| GO:0007417 | central nervous system development | IDA | 25259927 |
| GO:0035307 | positive regulation of protein dephosphorylation | IDA | 22770216 |
Transcripts for ANKLE2 Gene
mRNA/cDNA for ANKLE2 Gene
- (7) REFSEQ mRNAs :
- (9) Additional mRNA sequences :
- (12) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for ANKLE2 Gene
CRISPR Products
-
OriGene CRISPR knockouts for ANKLE2
-
Santa Cruz Biotechnology (SCBT) CRISPR for ANKLE2
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miRNA Products
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Inhibitory RNA Products
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-
ViGene Biosciences ready-to-package AAV shRNAs for ANKLE2 gene
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-
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- VectorBuilder custom plasmid, inducible vectors for ANKLE2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ANKLE2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9a | · | 9b | ^ | 10 | ^ | 11a | · | 11b | · | 11c | ^ | 12a | · | 12b | ^ | 13a | · | 13b | · | 13c | ^ | 14a | · | 14b | · | 14c | ^ | 15a | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
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| SP6: | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| SP13: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP14: | - |
| ExUns: | 15b | ^ | 16 | ^ | 17a | · | 17b | ^ | 18 | ^ | 19a | · | 19b | ^ | 20a | · | 20b | · | 20c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||
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| SP3: | |||||||||||||||||||
| SP4: | |||||||||||||||||||
| SP5: | - | - | |||||||||||||||||
| SP6: | - | - | - | - | |||||||||||||||
| SP7: | |||||||||||||||||||
| SP8: | - | - | - | - | - | ||||||||||||||
| SP9: | |||||||||||||||||||
| SP10: | |||||||||||||||||||
| SP11: | |||||||||||||||||||
| SP12: | |||||||||||||||||||
| SP13: | |||||||||||||||||||
| SP14: | - | - |
Expression for ANKLE2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Blood (Hematopoietic System)
This gene is overexpressed in Fetal Brain (37.9) and Peripheral blood mononuclear cells (10.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ANKLE2 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of ANKLE2 Gene:
ANKLE2SOURCE GeneReport for Unigene cluster for ANKLE2 Gene:
Hs.654628Evidence on tissue expression from TISSUES for ANKLE2 Gene
- Nervous system(4.7)
- Skin(4.3)
- Liver(4.2)
- Lung(2.7)
Phenotype-based relationships between genes and organs from Gene ORGANizer for ANKLE2 Gene
Germ Layers:
- ectoderm
- mesoderm
Systems:
- integumentary
- nervous
- skeletal muscle
- skeleton
- urinary
Organs:
Head and neck:
- brain
- cerebellum
- chin
- cranial nerve
- eye
- eyelid
- face
- forehead
- head
- jaw
- lip
- mandible
- maxilla
- mouth
- neck
- skull
Thorax:
- chest wall
- clavicle
- rib
- rib cage
- scapula
- sternum
Abdomen:
- kidney
Pelvis:
- pelvis
- ureter
Limb:
- ankle
- arm
- digit
- elbow
- femur
- fibula
- finger
- foot
- forearm
- hand
- hip
- humerus
- knee
- lower limb
- radius
- shin
- shoulder
- thigh
- tibia
- toe
- ulna
- upper limb
- wrist
General:
- peripheral nerve
- peripheral nervous system
- skin
- spinal column
- spinal cord
- vertebrae
Primer Products
-
OriGene qPCR primer pairs for ANKLE2
No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ANKLE2 Gene
Orthologs for ANKLE2 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ANKLE2 34 |
|
||
| cow (Bos Taurus) |
Mammalia | ANKLE2 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | ANKLE2 34 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Ankle2 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Ankle2 34 16 35 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | ANKLE2 35 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | ANKLE2 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | ANKLE2 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | ANKLE2 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | ankle2 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | ankle2 34 35 |
|
||
| zdhhc8a 35 |
|
OneToMany | |||
| fruit fly (Drosophila melanogaster) |
Insecta | l(1)G0222 35 |
|
OneToOne | |
| worm (Caenorhabditis elegans) |
Secernentea | lem-4 35 |
|
OneToOne | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
OneToMany | |
| -- 35 |
|
OneToMany |
- Species where no ortholog for ANKLE2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for ANKLE2 Gene
No data available for Paralogs for ANKLE2 Gene
Variants for ANKLE2 Gene
| SNP ID | Clin | Chr 12 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs863225465 | Pathogenic, Microcephaly 16, primary, autosomal recessive (MCPH16) [MIM:616681] | 132,734,559(-) | ATGAG(C/G)TGGGG | intron-variant, reference, missense | |
| rs201785518 | Pathogenic | 132,729,818(+) | GAGTT(A/G)GTCTG | intron-variant, nc-transcript-variant, downstream-variant-500B, reference, stop-gained | |
| rs200911469 | Uncertain significance | 132,755,103(+) | TCAAT(A/C/T)GAGCC | nc-transcript-variant, reference, missense, utr-variant-5-prime | |
| rs1000055366 | -- | 132,757,917(+) | AGTTT(A/G)AGGAT | intron-variant, upstream-variant-2KB | |
| rs1000121981 | -- | 132,729,235(+) | AATCC(C/T)AGCTA | intron-variant |
Residual Variation Intolerance Score:
39.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
11.88;
93.51% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for ANKLE2 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANKLE2 Gene
Disorders for ANKLE2 Gene
(4) MalaCards diseases for ANKLE2 Gene - From: ClinVar, Orphanet, Swiss-Prot, DISEASES, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| microcephaly 16, primary, autosomal recessive |
|
|
| autosomal recessive primary microcephaly |
|
|
| smallpox |
|
|
| scurvy |
|
|
Search ANKLE2 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
ANKL2_HUMAN- Microcephaly 16, primary, autosomal recessive (MCPH16) [MIM:616681]: A form of microcephaly, a disease defined as a head circumference more than 3 standard deviations below the age, sex and ethnically matched mean. Brain weight is markedly reduced and the cerebral cortex is disproportionately small. {ECO:0000269 PubMed:25259927}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Relevant External Links for ANKLE2
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- ANKLE2
No data available for Genatlas for ANKLE2 Gene
Publications for ANKLE2 Gene
- Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9734811) Ishikawa K. … Ohara O. (DNA Res. 1998) 2 3 4 64
- A drosophila genetic resource of mutants to study mechanisms underlying human genetic diseases. (PMID: 25259927) Yamamoto S. … Bellen H.J. (Cell 2014) 3 4 64
- Coordination of kinase and phosphatase activities by Lem4 enables nuclear envelope reassembly during mitosis. (PMID: 22770216) Asencio C. … Gorjanacz M. (Cell 2012) 3 4 64
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
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- Novus Biologicals Antibodies for ANKLE2
- Novus Biologicals proteins for ANKLE2
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- ViGene Biosciences adenoviral particle packaged cDNA for ANKLE2 gene
- ViGene Biosciences lentiviral particle packaged cDNA for ANKLE2 gene
- ViGene Biosciences ready-to-package AAV shRNAs for ANKLE2 gene
- Search ViGene Biosciences for ANKLE2
- Custom Antibody ServicesProSci Antibodies for ANKLE2
- Search for ANKLE2 Proteins at ProSci
- Cyagen custom Knockout/knockin (KOKI) mouse models for ANKLE2
- VectorBuilder custom plasmid, inducible vectors for ANKLE2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ANKLE2
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for ANKLE2 Gene
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