Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ANKLE2 Gene

Aliases for ANKLE2 Gene

  • Ankyrin Repeat And LEM Domain Containing 2 2 3
  • KIAA0692 2 3 4
  • LEM Domain-Containing Protein 4 3 4
  • LEM Domain Containing 7 2 3
  • Lem4 3 4
  • Ankyrin Repeat And LEM Domain-Containing Protein 2 3
  • LEMD7 3

External Ids for ANKLE2 Gene

Previous Symbols for ANKLE2 Gene

  • KIAA0692

Summaries for ANKLE2 Gene

Entrez Gene Summary for ANKLE2 Gene

  • This gene encodes a member of the LEM family of inner nuclear membrane proteins. The encoded protein functions as a mitotic regulator through postmitotic formation of the nuclear envelope. Mutations in this gene cause morphology defects in the nuclear envelope and BAF hyperphosphorylation. [provided by RefSeq, Mar 2014]

GeneCards Summary for ANKLE2 Gene

ANKLE2 (Ankyrin Repeat And LEM Domain Containing 2) is a Protein Coding gene. Diseases associated with ANKLE2 include scurvy and villonodular synovitis. Among its related pathways are Cell Cycle, Mitotic and Cell Cycle, Mitotic. GO annotations related to this gene include protein phosphatase type 2A regulator activity and protein phosphatase 2A binding.

UniProtKB/Swiss-Prot for ANKLE2 Gene

  • Involved in mitotic nuclear envelope reassembly by promoting dephosphorylation of BAF/BANF1 during mitotic exit. Coordinates the control of BAF/BANF1 dephosphorylation by inhibiting VRK1 kinase and promoting dephosphorylation of BAF/BANF1 by protein phosphatase 2A (PP2A), thereby facilitating nuclear envelope assembly. It is unclear whether it acts as a real PP2A regulatory subunit or whether it is involved in recruitment of the PP2A complex.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANKLE2 Gene

Genomics for ANKLE2 Gene

Genomic Location for ANKLE2 Gene

Start:
132,725,503 bp from pter
End:
132,761,888 bp from pter
Size:
36,386 bases
Orientation:
Minus strand

Genomic View for ANKLE2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ANKLE2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANKLE2 Gene

Regulatory Elements for ANKLE2 Gene

Proteins for ANKLE2 Gene

  • Protein details for ANKLE2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86XL3-ANKL2_HUMAN
    Recommended name:
    Ankyrin repeat and LEM domain-containing protein 2
    Protein Accession:
    Q86XL3
    Secondary Accessions:
    • A8KAG3
    • B3KN97
    • B3KSF8
    • O75176
    • Q6P6A5
    • Q8TAZ9
    • Q96DH4

    Protein attributes for ANKLE2 Gene

    Size:
    938 amino acids
    Molecular mass:
    104114 Da
    Quaternary structure:
    • Interacts with BAF/BANF1. Interacts with protein phosphatase 2A (PP2A) components PPP2C (PPP2CA or PPP2CB) and PPP2R1A.
    SequenceCaution:
    • Sequence=BAG51259.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for ANKLE2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ANKLE2 Gene

Proteomics data for ANKLE2 Gene at MOPED

Post-translational modifications for ANKLE2 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys90 and Lys394

Other Protein References for ANKLE2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for ANKLE2 Gene

Domains for ANKLE2 Gene

Gene Families for ANKLE2 Gene

HGNC:
  • ANKRD :Ankyrin repeat domain containing

UniProtKB/Swiss-Prot:

ANKL2_HUMAN
Domain:
  • Contains 1 LEM domain.:
    • Q86XL3
Family:
  • Belongs to the ANKLE2 family.:
    • Q86XL3
Similarity:
  • Contains 1 ANK repeat.:
    • Q86XL3
genes like me logo Genes that share domains with ANKLE2: view

Function for ANKLE2 Gene

Molecular function for ANKLE2 Gene

UniProtKB/Swiss-Prot Function: Involved in mitotic nuclear envelope reassembly by promoting dephosphorylation of BAF/BANF1 during mitotic exit. Coordinates the control of BAF/BANF1 dephosphorylation by inhibiting VRK1 kinase and promoting dephosphorylation of BAF/BANF1 by protein phosphatase 2A (PP2A), thereby facilitating nuclear envelope assembly. It is unclear whether it acts as a real PP2A regulatory subunit or whether it is involved in recruitment of the PP2A complex.

Gene Ontology (GO) - Molecular Function for ANKLE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 22770216
GO:0008601 protein phosphatase type 2A regulator activity TAS 22770216
GO:0051721 protein phosphatase 2A binding IDA 22770216
genes like me logo Genes that share ontologies with ANKLE2: view

miRNA for ANKLE2 Gene

miRTarBase miRNAs that target ANKLE2

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ANKLE2 Gene

Localization for ANKLE2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ANKLE2 Gene

Endoplasmic reticulum membrane; Single-pass type III membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ANKLE2 Gene COMPARTMENTS Subcellular localization image for ANKLE2 gene
Compartment Confidence
endoplasmic reticulum 5
cytosol 3
nucleus 2

Gene Ontology (GO) - Cellular Components for ANKLE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016020 membrane IDA 19946888
GO:0030176 integral component of endoplasmic reticulum membrane IDA 22770216
genes like me logo Genes that share ontologies with ANKLE2: view

Pathways for ANKLE2 Gene

genes like me logo Genes that share pathways with ANKLE2: view

Pathways by source for ANKLE2 Gene

Gene Ontology (GO) - Biological Process for ANKLE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle TAS --
GO:0007067 mitotic nuclear division IEA --
GO:0007084 mitotic nuclear envelope reassembly TAS --
GO:0034047 regulation of protein phosphatase type 2A activity TAS 22770216
GO:0035307 positive regulation of protein dephosphorylation IDA 22770216
genes like me logo Genes that share ontologies with ANKLE2: view

Transcripts for ANKLE2 Gene

mRNA/cDNA for ANKLE2 Gene

(8) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(12) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ANKLE2 Gene

Ankyrin repeat and LEM domain containing 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ANKLE2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b ^ 13a · 13b · 13c ^ 14a · 14b · 14c ^ 15a ·
SP1: - - - - - - - -
SP2: - - - - -
SP3: -
SP4: - -
SP5: - - -
SP6: - - - - - - - - - - - -
SP7: - - -
SP8: - - -
SP9:
SP10: - -
SP11: -
SP12:
SP13: -
SP14: -

ExUns: 15b ^ 16 ^ 17a · 17b ^ 18 ^ 19a · 19b ^ 20a · 20b · 20c
SP1: - -
SP2:
SP3:
SP4:
SP5: - -
SP6: - - - -
SP7:
SP8: - - - - -
SP9:
SP10:
SP11:
SP12:
SP13:
SP14: - -

Relevant External Links for ANKLE2 Gene

GeneLoc Exon Structure for
ANKLE2
ECgene alternative splicing isoforms for
ANKLE2

Expression for ANKLE2 Gene

mRNA expression in normal human tissues for ANKLE2 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ANKLE2 Gene

SOURCE GeneReport for Unigene cluster for ANKLE2 Gene Hs.654628

genes like me logo Genes that share expressions with ANKLE2: view

Orthologs for ANKLE2 Gene

This gene was present in the common ancestor of animals.

Orthologs for ANKLE2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ANKLE2 36
  • 99.51 (n)
  • 99.02 (a)
cow
(Bos Taurus)
Mammalia ANKLE2 36
  • 80.89 (n)
  • 77.28 (a)
ANKLE2 37
  • 74 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ANKLE2 36
  • 79.96 (n)
  • 75.69 (a)
ANKLE2 37
  • 74 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ankle2 36
  • 75.97 (n)
  • 70.8 (a)
Ankle2 16
Ankle2 37
  • 68 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ANKLE2 37
  • 58 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ANKLE2 37
  • 60 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ankle2 36
  • 76.6 (n)
  • 71.35 (a)
chicken
(Gallus gallus)
Aves ANKLE2 36
  • 66.78 (n)
  • 63.16 (a)
ANKLE2 37
  • 56 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ANKLE2 37
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ankle2 36
  • 60.38 (n)
  • 59.9 (a)
zebrafish
(Danio rerio)
Actinopterygii ankle2 36
  • 58.49 (n)
  • 56.19 (a)
ankle2 37
  • 46 (a)
OneToMany
zdhhc8a 37
  • 44 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta l(1)G0222 37
  • 18 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea lem-4 37
  • 30 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 38 (a)
OneToMany
-- 37
  • 24 (a)
OneToMany
Species with no ortholog for ANKLE2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ANKLE2 Gene

ENSEMBL:
Gene Tree for ANKLE2 (if available)
TreeFam:
Gene Tree for ANKLE2 (if available)

Paralogs for ANKLE2 Gene

No data available for Paralogs for ANKLE2 Gene

Variants for ANKLE2 Gene

Sequence variations from dbSNP and Humsavar for ANKLE2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs15683 -- 132,727,248(-) GCCGC(C/T)CTGTA reference, synonymous-codon, utr-variant-3-prime
rs1132375 - 132,754,951(-) TCTAC(C/T)ACCAT reference, missense
rs1132379 -- 132,726,524(-) CAAGG(A/T)GTTCC utr-variant-3-prime
rs3924362 -- 132,748,882(-) TGTGT(A/G)TATAT intron-variant
rs3924363 -- 132,748,766(-) TGAGC(C/T)ATATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ANKLE2 Gene

Variant ID Type Subtype PubMed ID
dgv1534n71 CNV Loss 21882294
nsv53840 CNV Insertion 16902084
esv21605 CNV Gain 19812545
esv2747035 CNV Deletion 23290073
esv2328159 CNV Deletion 18987734
nsv53329 CNV Loss 16902084
esv2747036 CNV Deletion 23290073
dgv1544n71 CNV Loss 21882294
nsv513379 CNV Insertion 21212237
esv2621079 CNV Insertion 19546169
esv2747037 CNV Deletion 23290073
esv2747038 CNV Deletion 23290073
esv1009039 CNV Deletion 20482838
esv1331463 CNV Deletion 17803354
esv2747039 CNV Deletion 23290073

Relevant External Links for ANKLE2 Gene

HapMap Linkage Disequilibrium report
ANKLE2

Disorders for ANKLE2 Gene

(2) University of Copenhagen DISEASES for ANKLE2 Gene

genes like me logo Genes that share disorders with ANKLE2: view

No data available for UniProtKB/Swiss-Prot for ANKLE2 Gene

Publications for ANKLE2 Gene

  1. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9734811) Ishikawa K. … Ohara O. (DNA Res. 1998) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Coordination of kinase and phosphatase activities by Lem4 enables nuclear envelope reassembly during mitosis. (PMID: 22770216) Asencio C. … Gorjanacz M. (Cell 2012) 3 4
  5. LGALS3BP regulates centriole biogenesis and centrosome hypertrophy in cancer cells. (PMID: 23443559) Fogeron M.L. … Lange B.M. (Nat Commun 2013) 3

Products for ANKLE2 Gene

  • antibodies-online peptides for ANKLE2
  • antibodies-online antibodies for ANKLE2
  • antibodies-online kits for ANKLE2

Sources for ANKLE2 Gene

Back to Top

Content