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ANKLE1 Gene

protein-coding   GIFtS: 45
GCID: GC19P017901

Ankyrin Repeat And LEM Domain Containing 1

(Previous name: ankyrin repeat domain 41)
(Previous symbol: ANKRD41)
  Search for ANKLE1
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ankyrin Repeat And LEM Domain Containing 11 2     Ankyrin Repeat Domain 411
ANKRD411 2 3     LEMD62
LEM Domain Containing 61 2     Ankyrin Repeat And LEM Domain-Containing Protein 12
Ankyrin Repeat Domain-Containing Protein 412 3     LEM-Domain Containing 32
LEM32 3     LEM-Domain Containing Protein 33

External Ids:    HGNC: 268121   Entrez Gene: 1265492   Ensembl: ENSG000001601177   UniProtKB: Q8NAG63   

Export aliases for ANKLE1 gene to outside databases

Previous GC identifers: GC19P017255 GC19P017394 GC19P016959 GC19P017470


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ANKLE1 Gene:
ANKLE1 (ankyrin repeat and LEM domain containing 1) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the ANKLE1 gene promoter:
         ER-alpha   Pax-2   MyoD   Pax-2a   YY1   CREB   deltaCREB   LyF-1   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ANKLE1 promoter sequence
   Search Chromatin IP Primers for ANKLE1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ANKLE1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.11   Ensembl cytogenetic band:  19p13.11   HGNC cytogenetic band: 19p13.11

ANKLE1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ANKLE1 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P017901:  view genomic region     (about GC identifiers)

Start:
17,392,454 bp from pter      End:
17,398,455 bp from pter
Size:
6,002 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ANKL1_HUMAN, Q8NAG6 (See protein sequence)
Recommended Name: Ankyrin repeat and LEM domain-containing protein 1  
Size: 615 amino acids; 66890 Da
Sequence caution: Sequence=BAC04840.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: A8VU82 Q8N8J8
Alternative splicing: 2 isoforms:  Q8NAG6-2   Q8NAG6-1   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ANKLE1: NX_Q8NAG6

Explore proteomics data for ANKLE1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys354
  • Modification sites at PhosphoSitePlus

  • See ANKLE1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001265372.1  NP_001265373.1  NP_001265374.1  NP_689576.5  

    ENSEMBL proteins: 
     ENSP00000384753   ENSP00000377971   ENSP00000384008   ENSP00000468845   ENSP00000470895  
     ENSP00000394460  

    ANKLE1 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for ANKLE1

     
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    LSBio Antibodies in human, mouse, rat for ANKLE1

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    Cloud-Clone Corp. CLIAs for ANKLE1
    Search eBioscience for ELISAs for ANKLE1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ANKRD: Ankyrin repeat domain containing

    5 InterPro protein domains:
     IPR003887 LEM_dom
     IPR011015 LEM/LEM-like_dom
     IPR002110 Ankyrin_rpt
     IPR000305 GIY-YIG_SF
     IPR020683 Ankyrin_rpt-contain_dom

    Graphical View of Domain Structure for InterPro Entry Q8NAG6

    ProtoNet protein and cluster: Q8NAG6

    UniProtKB/Swiss-Prot: ANKL1_HUMAN, Q8NAG6
    Similarity: Contains 3 ANK repeats
    Similarity: Contains 1 GIY-YIG domain
    Similarity: Contains 1 LEM domain


    Find genes that share domains with ANKLE1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0005515protein binding ----
    GO:0016616oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor ----
         
    Find genes that share ontologies with ANKLE1           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for ANKLE1:
     Decreased viability with pacli  Increased circadian period len 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ANKLE1
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ANKLE1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ANKLE1

    miRNA
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    4 qRT-PCR Assays for microRNAs that regulate ANKLE1:
    hsa-miR-920 hsa-miR-4300 hsa-miR-766 hsa-miR-3670
    SwitchGear 3'UTR luciferase reporter plasmidANKLE1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ANKLE1

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANKLE1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ANKLE1
    Interactions:

        Search GeneGlobe Interaction Network for ANKLE1

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    3 Interacting proteins for ANKLE1 (Q8NAG63 ENSP000003847534) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SUMO1P631653, ENSP000003760764I2D: score=1 STRING: ENSP00000376076
    RASSF5Q8WWW03I2D: score=1 
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process ----
    GO:0055114oxidation-reduction process ----

    Find genes that share ontologies with ANKLE1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ANKLE1 (ANKL1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ANKLE1 gene (4 alternative transcripts): 
    NM_001278443.1  NM_001278444.1  NM_001278445.1  NM_152363.5  

    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000404261 ENST00000394458(uc002nfy.2 uc002nfz.2) ENST00000601401
    ENST00000404085(uc010xpm.1 uc002nga.2 uc010eao.1 uc010xpn.1)
    ENST00000594072 ENST00000596626 ENST00000598347 ENST00000596834 ENST00000596099
    ENST00000433424
    miRNA
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    4 qRT-PCR Assays for microRNAs that regulate ANKLE1:
    hsa-miR-920 hsa-miR-4300 hsa-miR-766 hsa-miR-3670
    SwitchGear 3'UTR luciferase reporter plasmidANKLE1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ANKLE1
    Predesigned siRNA for gene silencing in human, mouse, rat ANKLE1
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ANKLE1
      QuantiTect SYBR Green Assays in human, mouse, rat ANKLE1
      QuantiFast Probe-based Assays in human, mouse, rat ANKLE1

    Selected AceView cDNA sequences (see all 26):

    BQ057461 BQ642145 BX644665 NM_152363 AW875188 AX747681 BQ063138 BQ058259 
    AK096688 BQ433179 BQ423817 AK092706 AW467458 AW249299 BQ055213 AW572870 
    AW248879 BQ059246 BQ224491 BQ061246 BF982291 BM927676 BU656024 BG258016 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for ANKLE1    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
    SP1:                                                                                    
    SP2:                                      -                                             
    SP3:                                      -                                             
    SP4:                                                                                    
    SP5:                                                                                    


    ECgene alternative splicing isoforms for ANKLE1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ANKLE1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ANKLE1 Expression
    About this image


    ANKLE1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Blood (Hematopoietic System)
             Proerythroblasts Hematopoietic Bone Marrow
    ANKLE1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ANKLE1 Protein Expression
        Custom PCR Arrays for ANKLE1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANKLE1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ANKLE1 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ankle11 , 5 ankyrin repeat and LEM domain containing 11, 5 64.6(n)1
    64.03(a)1
      8 (34.43 cM)5
    2343961  NM_172756.21  NP_766344.21 
     714060105 
    chicken
    (Gallus gallus)
    Aves ANKLE16
    ankyrin repeat and LEM domain containing 1
    42(a)
    1 ↔ 1
    JH375512.1(9363-12559)
    lizard
    (Anolis carolinensis)
    Reptilia ANKLE16
    ankyrin repeat and LEM domain containing 1
    36(a)
    1 ↔ 1
    AAWZ02039196(21-6756)
    zebrafish
    (Danio rerio)
    Actinopterygii ANKLE16
    ankyrin repeat and LEM domain containing 1
    25(a)
    1 ↔ 1
    19(49764192-49773495) ENSDARG00000087529
    fruit fly
    (Drosophila melanogaster)
    Insecta CG423916
    CG86796
    --
    30(a)
    22(a)
    many → 1
    many → 1
    2R(11089698-11090492)
    2L(21216004-21218544)


    ENSEMBL Gene Tree for ANKLE1 (if available)
    TreeFam Gene Tree for ANKLE1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ANKLE1 (see all 310)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1146205401,2
    F--17390785(+) CAGGAA/GATGCA 1 -- us2k11Minor allele frequency- G:0.04WA 118
    rs1869678821,2
    C--17390817(+) GCTCAC/TGCCTG 1 -- us2k10--------
    rs1157585541,2
    F--17390869(+) TGAACC/TTAGGA 1 -- us2k11Minor allele frequency- T:0.04WA 118
    rs1913352471,2
    --17390878(+) GAGGTC/TGAGGC 1 -- us2k10--------
    rs46099721,2
    C,F,A,H--17390917(+) CTCTAG/CCCTGG 1 -- us2k111Minor allele frequency- C:0.44NA CSA WA EA 371
    rs1437139611,2
    --17390981(+) ACTGCG/TTTTCC 1 -- us2k10--------
    rs81075011,2
    C--17391039(+) CCAAGC/TCCCTG 1 -- us2k14Minor allele frequency- T:0.07WA NA EA 360
    rs1850467221,2
    --17391066(+) ACCTCA/GTTAGG 1 -- us2k10--------
    rs1471440111,2
    --17391131(+) AATACC/TGAAGT 1 -- us2k10--------
    rs1486043991,2
    C--17391137(+) GAAGTC/TCTAGT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ANKLE1 (17392454 - 17398455 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for ANKLE1 (see all 15):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2661731CNV Deletion23128226
    esv2674696CNV Deletion23128226
    nsv911199CNV Loss21882294
    dgv3760n71CNV Loss21882294
    nsv911182CNV Loss21882294
    dgv3757n71CNV Loss21882294
    nsv911198CNV Loss21882294
    nsv515965CNV Loss19592680
    nsv911188CNV Loss21882294
    nsv911185CNV Loss21882294

    Human Gene Mutation Database (HGMD): ANKLE1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ANKLE1
    DNA2.0 Custom Variant and Variant Library Synthesis for ANKLE1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with ANKLE1           About GenesLikeMe

    Genetic Association Database (GAD): ANKLE1
    Human Genome Epidemiology (HuGE) Navigator: ANKLE1 (3 documents)

    Export disorders for ANKLE1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ANKLE1 gene, integrated from 10 sources (see all 14):
    (articles sorted by number of sources associating them with ANKLE1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A locus on 19p13 modifies risk of breast cancer in BRCA1 mutation carriers and is associated with hormone receptor-negative breast cancer in the general population. (PubMed id 20852631)1, 4 Antoniou A.C....Couch F.J. (Nat. Genet. 2010)
    2. Common variants at 19p13 are associated with susceptibility to ovarian cancer. (PubMed id 20852633)1, 4 Bolton K.L....Gayther S.A. (Nat. Genet. 2010)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. A meta-analysis of genome-wide association studies of breast cancer identifies two novel susceptibility loci at 6q14 and 20q11. (PubMed id 22976474)1 Siddiq A....Vachon C.M. (Hum. Mol. Genet. 2012)
    5. The endonuclease Ankle1 requires its LEM and GIY-YIG motifs for DNA cleavage in vivo. (PubMed id 22399800)1 Brachner A....Foisner R. (J. Cell. Sci. 2012)
    6. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    7. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    8. New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496)1 Davila S....Seielstad M. (Genes Immun. 2010)
    9. Broad spectrum identification of SUMO substrates in melanoma cells. (PubMed id 17549794)1 Ganesan A.K....White M.A. (Proteomics 2007)
    10. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 126549 HGNC: 26812 AceView: FLJ39369 Ensembl:ENSG00000160117 euGenes: HUgn126549
    ECgene: ANKLE1 H-InvDB: ANKLE1

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ANKLE1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ANKLE1 gene:
    Search GeneIP for patents involving ANKLE1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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