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ANKK1 Gene

protein-coding   GIFtS: 51
GCID: GC11P113258

Ankyrin Repeat And Kinase Domain Containing 1

  See ANKK1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ankyrin Repeat And Kinase Domain Containing 11 2     Ankyrin Repeat And Protein Kinase Domain-Containing Protein 12
Protein Kinase PKK22 3     sgK2882
Sugen Kinase 2882 3     SGK2883
PKK22 3     SgK2883
X-kinase2 3     EC 2.7.118
EC 2.7.11.13 8     

External Ids:    HGNC: 210271   Entrez Gene: 2552392   Ensembl: ENSG000001702097   OMIM: 6087745   UniProtKB: Q8NFD23   

Export aliases for ANKK1 gene to outside databases

Previous GC identifers: GC11P113292 GC11P112796 GC11P112763 GC11P109186


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ANKK1 Gene:
The protein encoded by this gene belongs to the Ser/Thr protein kinase family, and protein kinase superfamily
involved in signal transduction pathways. This gene is closely linked to DRD2 gene (GeneID:1813) on chr 11, and a
well studied restriction fragment length polymorphism (RFLP) designated TaqIA, was originally associated with the
DRD2 gene, however, later was determined to be located in exon 8 of ANKK1 gene (PMIDs: 18621654, 15146457), where
it causes a nonconservative amino acid substitution. It is not clear if this gene plays any role in
neuropsychiatric disorders previously associated with Taq1A RFLP. (provided by RefSeq, Sep 2009)

GeneCards Summary for ANKK1 Gene:
ANKK1 (ankyrin repeat and kinase domain containing 1) is a protein-coding gene. Diseases associated with ANKK1 include dopamine receptor d2, reduced brain density of, and heroin dependence. GO annotations related to this gene include protein serine/threonine kinase activity. An important paralog of this gene is RIPK3.

Gene Wiki entry for ANKK1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NT_033899.9  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ANKK1 gene promoter:
         HFH-3   C/EBPbeta   p53   AREB6   FOXI1   POU2F1   POU2F1b   POU2F1a   FOXJ2 (long isoform)   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidANKK1 promoter sequence
   Search Chromatin IP Primers for ANKK1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ANKK1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q23.2   Ensembl cytogenetic band:  11q23.2   HGNC cytogenetic band: 11q23.2

ANKK1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ANKK1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P113258:  view genomic region     (about GC identifiers)

Start:
113,258,513 bp from pter      End:
113,271,140 bp from pter
Size:
12,628 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ANKK1_HUMAN, Q8NFD2 (See protein sequence)
Recommended Name: Ankyrin repeat and protein kinase domain-containing protein 1  
Size: 765 amino acids; 84632 Da

Explore the universe of human proteins at neXtProt for ANKK1: NX_Q8NFD2

Explore proteomics data for ANKK1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • 2 DME Specific Peptides for ANKK1 (Q8NFD2)
     KPGNILL  LHLDLKP 


    See ANKK1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_848605.1  
    ENSEMBL proteins: 
     ENSP00000306678   ENSP00000445810  

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    antibodies-online proteins for ANKK1 (2 products) 

     
    antibodies-online peptides for ANKK1

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ANKRD: Ankyrin repeat domain containing

    IUPHAR Guide to PHARMACOLOGY protein family classification: ankyrin repeat and kinase domain containing 1
    Receptor interacting protein kinase (RIPK) family

    Selected InterPro protein domains (see all 6):
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_dom
     IPR002110 Ankyrin_rpt
     IPR001245 Ser-Thr/Tyr_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry Q8NFD2

    ProtoNet protein and cluster: Q8NFD2

    UniProtKB/Swiss-Prot: ANKK1_HUMAN, Q8NFD2
    Similarity: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family
    Similarity: Contains 12 ANK repeats
    Similarity: Contains 1 protein kinase domain


    Find genes that share domains with ANKK1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ANKK1_HUMAN, Q8NFD2
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein

         Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity IEA--
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding ----
    GO:0005524ATP binding IEA--
         
    Find genes that share ontologies with ANKK1           About GenesLikeMe


    Phenotypes:
         4 GenomeRNAi human phenotypes for ANKK1:
     Decreased focal adhesion (FA)   Decreased influenza A/WSN/33 r  Decreased substrate adherent c  Decreased viability 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for ANKK1

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    cytoskeleton2
    nucleus2
    endoplasmic reticulum1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ANKK1
    Interactions:

        GeneGlobe Interaction Network for ANKK1

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation ----

    Find genes that share ontologies with ANKK1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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      Browse compounds at ApexBio 

    Browse Tocris compounds for ANKK1

    Selected PharmGKB related drug/compound annotations for ANKK1 gene (see all 11)    About this table
    Drug/compound PharmGKB Annotation
    Drugs used in nicotine dependenceCA  
    antipsychoticsCA  
    bupropionCA  
    clozapineCA  
    disulfiramCA  
    ethanolCA  
    methadoneCA  
    nemonaprideCA  
    nicotineCA  
    olanzapineCA  



    Find genes that share compounds with ANKK1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ANKK1 gene: 
    NM_178510.1  

    Unigene Cluster for ANKK1:

    Ankyrin repeat and kinase domain containing 1
    Hs.448473  [show with all ESTs]
    Unigene Representative Sequence: AJ541797
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000303941(uc001pny.3) ENST00000542948
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    Additional mRNA sequence: 

    AF487542.1 AJ541797.2 

    1 DOTS entry:

    DT.100736992 

    3 AceView cDNA sequences:

    NM_178510 AF487542 AJ541797 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for ANKK1    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8
    SP1:                    -                                       
    SP2:                                                            


    ECgene alternative splicing isoforms for ANKK1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ANKK1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ANKK1 Expression
    About this image

    ANKK1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ANKK1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.448473

    UniProtKB/Swiss-Prot: ANKK1_HUMAN, Q8NFD2
    Tissue specificity: Highly expressed in brain and weakly expressed in placenta and spinal cord

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ANKK1 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ankk11 , 5 ankyrin repeat and kinase domain containing 11, 5 81.67(n)1
    79.54(a)1
      9 (26.83 cM)5
    2448591  NM_172922.31  NP_766510.11 
     494152225 
    chicken
    (Gallus gallus)
    Aves ANKK11 ankyrin repeat and kinase domain containing 1 67.7(n)
    62.77(a)
      100859406  XM_003642615.2  XP_003642663.2 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    20(a)
    many ↔ many
    LGc(6849338-6872565)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia ankk11 ankyrin repeat and kinase domain containing 1 57.9(n)
    55.07(a)
      100493231  XM_002937826.2  XP_002937872.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ankk11 ankyrin repeat and kinase domain containing 1 53.03(n)
    42.88(a)
      100170831  NM_001130665.1  NP_001124137.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons KEG1 KEG 41.44(n)
    28.99(a)
      831197  NM_121356.2  NP_196857.2 


    ENSEMBL Gene Tree for ANKK1 (if available)
    TreeFam Gene Tree for ANKK1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ANKK1 gene
    RIPK32  RIPK42  RIPK12  RIPK22  
    13 SIMAP similar genes for ANKK1 using alignment to 3 protein entries:     ANKK1_HUMAN (see all proteins):
    IkBa    MARK4    NRARP    DKFZp434B2328    PSMD10    PPP1R12A
    CDKN2C    CDKN2D    dik    ANKRD29    RIPK4    NUAK1
    ANKDD1A

    Find genes that share paralogs with ANKK1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ANKK1 (see all 441)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0403734
    A lung squamous cell carcinoma sample4--see VAR_0403732 R L mis40--------
    VAR_0403744
    A lung neuroendocrine carcinoma sample4--see VAR_0403742 E K mis40--------
    VAR_0403724
    A lung large cell carcinoma sample4--see VAR_0403722 Q L mis40--------
    VAR_0403624
    A breast infiltrating ductal carcinoma sample4--see VAR_0403622 K T mis40--------
    rs18004971,2,,4
    C,F,O,A,Hpathogenic1113134184(-) TGCCTC/TGACCA 2 K E mis129Minor allele frequency- T:0.30MN EU NA NS EA CSA WA 3658
    rs347166411,2
    C--109194688(+) TTTTT-/TTTTTT 1 -- int11Minor allele frequency- T:0.00NA 2
    rs1390541941,2
    --113119975(+) TGACTC/TAGGCC 1 -- us2k10--------
    rs1843253061,2
    --113120075(+) GGCTGG/TTCACC 1 -- us2k10--------
    rs1891731791,2
    --113120263(+) AGCCAA/GAGCAA 1 -- us2k10--------
    rs569471741,2
    F--113120312(+) TCCTGC/TTCCTG 1 -- us2k11Minor allele frequency- T:0.03WA 118

    HapMap Linkage Disequilibrium report for ANKK1 (113258513 - 113271140 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for ANKK1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv515795CNV Loss19592680

    Human Gene Mutation Database (HGMD): ANKK1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ANKK1
    DNA2.0 Custom Variant and Variant Library Synthesis for ANKK1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608774    OMIM disorders: --

    10 diseases for ANKK1:    
    About MalaCards
    dopamine receptor d2, reduced brain density of    heroin dependence    alexithymia    bipolar i disorder
    tardive dyskinesia    neuroleptic malignant syndrome    antisocial personality disorder    alcohol dependence
    traumatic brain injury    nicotine dependence

    5 diseases from the University of Copenhagen DISEASES database for ANKK1:
    Nicotine dependence     Alcohol dependence     Antisocial personality disorder     Alexithymia
    Heroin dependence

    Find genes that share disorders with ANKK1           About GenesLikeMe

    Genetic Association Database (GAD): ANKK1
    Human Genome Epidemiology (HuGE) Navigator: ANKK1 (39 documents)

    Export disorders for ANKK1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ANKK1 gene, integrated from 10 sources (see all 92):
    (articles sorted by number of sources associating them with ANKK1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of ANKK1: a novel kinase gene closely linked to DRD2 on chromosome band 11q23.1. (PubMed id 15146457)1, 2, 3, 9 Neville M.J.... Walton R.T. (Hum. Mutat. 2004)
    2. Family-based association analyses of alcohol dependence phenotypes across DRD2 and neighboring gene ANKK1. (PubMed id 17850642)1, 4, 9 Dick D.M....Goate A. (Alcohol. Clin. Exp. Res. 2007)
    3. Single nucleotide polymorphisms in ANKK1 and the dopamine D2 receptor gene affect cognitive outcome shortly after traumatic brain injury: a replication and extension study. (PubMed id 18698520)1, 4, 9 McAllister T.W....Tsongalis G.J. (Brain Inj 2008)
    4. Genetic diagnostics of functional variants of the human dopamine D2 receptor gene. (PubMed id 19512960)1, 4, 9 Doehring A....LAPtsch J. (Psychiatr. Genet. 2009)
    5. The 3' region of the DRD2 gene is involved in genetic susceptibility to schizophrenia. (PubMed id 14741327)1, 2, 9 Dubertret C....Gorwood P. (Schizophr. Res. 2004)
    6. Family-based analysis of genetic variation underlying psychosis-inducing effects of cannabis: sibling analysis and proband follow-up. (PubMed id 21041608)1, 4 van Winkel R. (Arch. Gen. Psychiatry 2011)
    7. Genetic, personality, and environmental predictors of drug use in adolescents. (PubMed id 19717274)1, 4 Conner B.T....Noble E.P. (J Subst Abuse Treat 2010)
    8. A genetic schizophrenia-susceptibility region located between the ANKK1 and DRD2 genes. (PubMed id 20138949)1, 4 Dubertret C....Gouya L. (amp 2010)
    9. The D2 dopamine receptor gene variant C957T affects human fear conditioning and aversive priming. (PubMed id 19900188)1, 4 Huertas E....Hoenicka J. (Genes Brain Behav. 2010)
    10. A large-scale candidate gene association study of age at menarche and age at natural menopause. (PubMed id 20734064)1, 4 He C....Hunter D.J. (Hum. Genet. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 255239 HGNC: 21027 AceView: ANKK1 Ensembl:ENSG00000170209 euGenes: HUgn255239
    ECgene: ANKK1 H-InvDB: ANKK1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ANKK1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ANKK1 gene:
    Search GeneIP for patents involving ANKK1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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