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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ANKK1 Gene

protein-coding   GIFtS: 52
GCID: GC11P113258

Ankyrin Repeat And Kinase Domain Containing 1
  23 related diseases
at
MalaCards
 

Aliases
for ANKK1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section
Aliases
Ankyrin Repeat And Kinase Domain Containing 11 2     Ankyrin Repeat And Protein Kinase Domain-Containing Protein 12
Protein Kinase PKK22 3     sgK2882
Sugen Kinase 2882 3     SGK2883
PKK22 3     SgK2883
X-kinase2 3     EC 2.7.118
EC 2.7.11.13 8     

External Ids:    HGNC: 210271   Entrez Gene: 2552392   Ensembl: ENSG000001702097   OMIM: 6087745   UniProtKB: Q8NFD23   

Export aliases for ANKK1 gene to outside databases

Previous GC identifers: GC11P113292 GC11P112796 GC11P112763 GC11P109186


Summaries
for ANKK1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for ANKK1 Gene:
The protein encoded by this gene belongs to the Ser/Thr protein kinase family, and protein kinase superfamily
involved in signal transduction pathways. This gene is closely linked to DRD2 gene (GeneID:1813) on chr 11, and a
well studied restriction fragment length polymorphism (RFLP) designated TaqIA, was originally associated with the
DRD2 gene, however, later was determined to be located in exon 8 of ANKK1 gene (PMIDs: 18621654, 15146457), where
it causes a nonconservative amino acid substitution. It is not clear if this gene plays any role in
neuropsychiatric disorders previously associated with Taq1A RFLP. (provided by RefSeq, Sep 2009)

GeneCards Summary for ANKK1 Gene: 
ANKK1 (ankyrin repeat and kinase domain containing 1) is a protein-coding gene. Diseases associated with ANKK1 include alexithymia, and keratinizing squamous cell carcinoma. GO annotations related to this gene include protein serine/threonine kinase activity and ATP binding. An important paralog of this gene is RIPK3.

Gene Wiki entry for ANKK1 Gene


Genomic Views
for ANKK1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.2  NT_033899.8  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ANKK1 gene promoter:
         HFH-3   C/EBPbeta   p53   AREB6   FOXI1   POU2F1   POU2F1b   POU2F1a   FOXJ2 (long isoform)   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ANKK1 promoter sequence
   Search SABiosciences Chromatin IP Primers for ANKK1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ANKK1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q23.2   Ensembl cytogenetic band:  11q23.2   HGNC cytogenetic band: 11q23.2

ANKK1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ANKK1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P113258:  view genomic region     (about GC identifiers)

Start:
 113,258,513 bp from pter      End:
 113,271,140 bp from pter
Size:
 12,628 bases      Orientation:
 plus strand

Proteins
for ANKK1 gene

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section
UniProtKB/Swiss-Prot: ANKK1_HUMAN, Q8NFD2 (See protein sequence)
Recommended Name: Ankyrin repeat and protein kinase domain-containing protein 1  
Size: 765 amino acids; 84632 Da

Explore the universe of human proteins at neXtProt for ANKK1: NX_Q8NFD2

Explore proteomics data for ANKK1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8NFD2

    • 2 DME Specific Peptides for ANKK1 (Q8NFD2)
     KPGNILL  LHLDLKP 

    ANKK1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ANKK1 Protein Expression
    REFSEQ proteins: NP_848605.1  
    ENSEMBL proteins: 
     ENSP00000306678   ENSP00000445810  

    Human Recombinant Protein Products for ANKK1: 
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    OriGene Protein Over-expression Lysate for ANKK1
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    Novus Biologicals ANKK1 Lysate
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    LSBio Antibodies in human, mouse, rat for ANKK1 

    Assay Products for ANKK1: 
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    Cloud-Clone Corp. ELISAs for ANKK1 
    Cloud-Clone Corp. CLIAs for ANKK1

    Protein Domains /
    Families
    for ANKK1 gene

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    		 HGNC Gene Families: 
    ANKRD: Ankyrin repeat domain containing

    IUPHAR Guide to PHARMACOLOGY protein family classification: ankyrin repeat and kinase domain containing 1 
    Receptor interacting protein kinase (RIPK) family

    5/6 InterPro protein domains (see all 6):
     IPR001245 Ser-Thr/Tyr_kinase_cat_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_cat_dom
     IPR020683 Ankyrin_rpt-contain_dom

    Graphical View of Domain Structure for InterPro Entry Q8NFD2

    ProtoNet protein and cluster: Q8NFD2

    UniProtKB/Swiss-Prot: ANKK1_HUMAN, Q8NFD2
    Similarity: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family
    Similarity: Contains 12 ANK repeats
    Similarity: Contains 1 protein kinase domain


    ANKK1 for domains           About GeneDecksing


    Function
    for ANKK1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ANKK1_HUMAN, Q8NFD2
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein

         Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity IEA--
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding ----
    GO:0005524ATP binding IEA--
         
    ANKK1 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for ANKK1:
     Decreased focal adhesion (FA)   Decreased influenza A/WSN/33 r  Decreased substrate adherent c  Decreased viability 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ANKK1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ANKK1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ANKK1 
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    miRNA
    Products:            		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ANKK1
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate ANKK1
    SwitchGear 3'UTR luciferase reporter plasmid: ANKK1 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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                         Customized lentivirus expression plasmids for stable overexpression of ANKK1 

    Cell Line
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    Search LifeMap BioReagents cell lines for ANKK1
    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANKK1


    Pathways & Interactions
    for ANKK1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ANKK1

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation ----

    ANKK1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for ANKK1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ANKK1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ANKK1

    10/10 PharmGKB related drug/compound annotations for ANKK1 gene (see all 10)    About this table
    Drug/compound PharmGKB Annotation
    Drugs used in nicotine dependenceCA  
    antipsychoticsCA  
    bupropionCA  
    clozapineCA  
    ethanolCA  
    methadoneCA  
    nemonaprideCA  
    nicotineCA  
    olanzapineCA  
    risperidoneCA  

    Search CenterWatch for drugs/clinical trials and news about ANKK1

    Transcripts
    for ANKK1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ANKK1 gene: 
    NM_178510.1  

    Unigene Cluster for ANKK1:

    Ankyrin repeat and kinase domain containing 1
    Hs.448473  [show with all ESTs]
    Unigene Representative Sequence: AJ541797
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000303941(uc001pny.3) ENST00000542948
    miRNA
    Products:             		 QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ANKK1
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate ANKK1
    SwitchGear 3'UTR luciferase reporter plasmid: ANKK1 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ANKK1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ANKK1
    Clone
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    OriGene ORF clones in mouse, rat for ANKK1
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ANKK1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ANKK1
    Sirion Biotech Customized lentivirus for stable overexpression of ANKK1 
                         Customized lentivirus expression plasmids for stable overexpression of ANKK1 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ANKK1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ANKK1

    Additional mRNA sequence: 

    AF487542.1 AJ541797.2 

    1 DOTS entry:

    DT.100736992 

    3 AceView cDNA sequences:

    AF487542 AJ541797 NM_178510 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for ANKK1    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8
    SP1:                    -                                       
    SP2:                                                            


    ECgene alternative splicing isoforms for ANKK1

    Expression
    for ANKK1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ANKK1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ANKK1 Expression
    About this image


    See ANKK1 Protein Expression from SPIRE MOPED and PaxDB
    SOURCE GeneReport for Unigene cluster: Hs.448473

    UniProtKB/Swiss-Prot: ANKK1_HUMAN, Q8NFD2
    Tissue specificity: Highly expressed in brain and weakly expressed in placenta and spinal cord

        SABiosciences Custom PCR Arrays for ANKK1
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ANKK1
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANKK1

    Orthologs
    for ANKK1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ANKK1 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Ankk11 , 5 ankyrin repeat and kinase domain containing 11, 5 81.67(n)1
    79.54(a)1    		   9 (26.83 cM)5
    2448591  NM_172922.31  NP_766510.11 
     494152225 
    chicken
    (Gallus gallus)    		 Aves LOC1008594061 ankyrin repeat and protein kinase domain-containing more 67.16(n)
    62.2(a)    		   100859406  XM_003642615.1  XP_003642663.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii ankk11 ankyrin repeat and kinase domain containing 1 53.17(n)
    43.16(a)    		   100170831  NM_001130665.1  NP_001124137.1 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons KEG1 E3 ubiquitin-protein ligase KEG 41.49(n)
    29.16(a)    		   831197  NM_121356.2  NP_196857.2 


    ENSEMBL Gene Tree for ANKK1 (if available)
    TreeFam Gene Tree for ANKK1 (if available)

    Paralogs
    for ANKK1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ANKK1 gene
    RIPK32  RIPK12  RIPK42  RIPK22  
    13 SIMAP similar genes for ANKK1 using alignment to 3 protein entries:     ANKK1_HUMAN (see all proteins):
    IkBa    MARK4    NRARP    DKFZp434B2328    PSMD10    PPP1R12A
    CDKN2C    CDKN2D    dik    ANKRD29    RIPK4    NUAK1
    ANKDD1A

    ANKK1 for paralogs           About GeneDecksing



    Genomic Variants
    for ANKK1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/441 SNPs in ANKK1 are shown (see all 441)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 11 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    VAR_0403734
    		A lung squamous cell carcinoma sample4--see VAR_0403732 R L mis40--------
    VAR_0403744
    		A lung neuroendocrine carcinoma sample4--see VAR_0403742 E K mis40--------
    VAR_0403724
    		A lung large cell carcinoma sample4--see VAR_0403722 Q L mis40--------
    VAR_0403624
    		A breast infiltrating ductal carcinoma sample4--see VAR_0403622 K T mis40--------
    rs18004971,2,4
    		C,F,O,A,Hpathogenic1113134184(-) TGCCTC/TGACCA 2 K E mis129Minor allele frequency- T:0.30MN EU NA NS EA CSA WA 3658
    rs347166411,2
    		C--109194688(+) TTTTT-/TTTTTT 1 -- int11Minor allele frequency- T:0.00NA 2
    rs1390541941,2
    		--113119975(+) TGACTC/TAGGCC 1 -- us2k10--------
    rs1843253061,2
    		--113120075(+) GGCTGG/TTCACC 1 -- us2k10--------
    rs1891731791,2
    		--113120263(+) AGCCAA/GAGCAA 1 -- us2k10--------
    rs569471741,2
    		F--113120312(+) TCCTGC/TTCCTG 1 -- us2k11Minor allele frequency- T:0.03WA 118

    HapMap Linkage Disequilibrium report for ANKK1 (113258513 - 113271140 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for ANKK1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv515795CNV Loss19592680


    Human Gene Mutation Database (HGMD): ANKK1
    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ANKK1
    DNA2.0 Custom Variant and Variant Library Synthesis for ANKK1

    Disorders / Diseases
    for ANKK1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    		 OMIM gene information: 608774    OMIM disorders: --

    20/23 diseases for ANKK1 (see all 23):    About MalaCards
    alexithymia    keratinizing squamous cell carcinoma    microcystic adenoma    pityriasis rubra pilaris
    bipolar i disorder    tardive dyskinesia    neuroleptic malignant syndrome    nicotine dependence
    antisocial personality disorder    erythrokeratodermia variabilis    traumatic brain injury    cocaine dependence
    alcohol dependence    drug dependence    alcohol abuse    brain injury
    personality disorder    alcoholism    schizophrenia    adenoma

    5 diseases from the University of Copenhagen DISEASES database for ANKK1:
    Nicotine dependence     Alcohol dependence     Antisocial personality disorder     Alexithymia
    Heroin dependence

    ANKK1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ANKK1
    Human Genome Epidemiology (HuGE) Navigator: ANKK1 (39 documents)

    Export disorders for ANKK1 gene to outside databases

    Publications
    for ANKK1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ANKK1 gene, integrated from 9 sources (see all 84):
    (articles sorted by number of sources associating them with ANKK1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of ANKK1: a novel kinase gene closely linked to DRD2 on chromosome band 11q23.1. (PubMed id 15146457)1, 2, 3, 9 Neville M.J.... Walton R.T. (2004)
    2. Family-based association analyses of alcohol dependence phenotypes across DRD2 and neighboring gene ANKK1. (PubMed id 17850642)1, 4, 9 Dick D.M....Goate A. (2007)
    3. Single nucleotide polymorphisms in ANKK1 and the dopamine D2 receptor gene affect cognitive outcome shortly after traumatic brain injury: a replication and extension study. (PubMed id 18698520)1, 4, 9 McAllister T.W....Tsongalis G.J. (2008)
    4. Genetic diagnostics of functional variants of the hum an dopamine D2 receptor gene. (PubMed id 19512960)1, 4, 9 Doehring A....LAPtsch J. (2009)
    5. The 3' region of the DRD2 gene is involved in genetic susceptibility to schizophrenia. (PubMed id 14741327)1, 2, 9 Dubertret C....Gorwood P. (2004)
    6. Genetic, personality, and environmental predictors of drug use in adolescents. (PubMed id 19717274)1, 4 Conner B.T....Noble E.P. (2010)
    7. Family-Based Analysis of Genetic Variation Underlying Psychosis-Inducing Effects of Cannabis: Sibling Analysis and Proband Follow-up . (PubMed id 21041608)1, 4 van Winkel R. (2010)
    8. A genetic schizophrenia-susceptibility region located between the ANKK1 and DRD2 genes. (PubMed id 20138949)1, 4 Dubertret C....Gouya L. (2010)
    9. A large-scale candidate gene association study of age at menarche and age at natural menopause. (PubMed id 20734064)1, 4 He C....Hunter D.J. (2010)
    10. Genetic susceptibility to distinct bladder cancer sub phenotypes. (PubMed id 19692168)1, 4 Guey L.T....Malats N. (2010)

    External Searches for ANKK1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing ANKK1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 255239 HGNC: 21027 AceView: ANKK1 Ensembl:ENSG00000170209 euGenes: HUgn255239
    ECgene: ANKK1 H-InvDB: ANKK1

    Other Databases showing ANKK1 gene

    (According to HUGE)
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    Specialized Databases showing ANKK1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ANKK1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for ANKK1 gene

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    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    		Patent Information for ANKK1 gene:
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