Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ANKK1 Gene

Aliases for ANKK1 Gene

  • Ankyrin Repeat And Kinase Domain Containing 1 2 3
  • Protein Kinase PKK2 3 4
  • Sugen Kinase 288 3 4
  • EC 2.7.11.1 4 63
  • X-Kinase 3 4
  • SgK288 3 4
  • PKK2 3 4
  • Ankyrin Repeat And Protein Kinase Domain-Containing Protein 1 3
  • EC 2.7.11 63

External Ids for ANKK1 Gene

Previous GeneCards Identifiers for ANKK1 Gene

  • GC11P113292
  • GC11P112796
  • GC11P112763
  • GC11P109186
  • GC11P113258

Summaries for ANKK1 Gene

Entrez Gene Summary for ANKK1 Gene

  • The protein encoded by this gene belongs to the Ser/Thr protein kinase family, and protein kinase superfamily involved in signal transduction pathways. This gene is closely linked to DRD2 gene (GeneID:1813) on chr 11, and a well studied restriction fragment length polymorphism (RFLP) designated TaqIA, was originally associated with the DRD2 gene, however, later was determined to be located in exon 8 of ANKK1 gene (PMIDs: 18621654, 15146457), where it causes a nonconservative amino acid substitution. It is not clear if this gene plays any role in neuropsychiatric disorders previously associated with Taq1A RFLP. [provided by RefSeq, Sep 2009]

GeneCards Summary for ANKK1 Gene

ANKK1 (Ankyrin Repeat And Kinase Domain Containing 1) is a Protein Coding gene. Diseases associated with ANKK1 include alexithymia and heroin dependence. GO annotations related to this gene include protein serine/threonine kinase activity. An important paralog of this gene is RIPK3.

Gene Wiki entry for ANKK1 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANKK1 Gene

Genomics for ANKK1 Gene

Regulatory Elements for ANKK1 Gene

Genomic Location for ANKK1 Gene

Start:
113,387,791 bp from pter
End:
113,400,418 bp from pter
Size:
12,628 bases
Orientation:
Plus strand

Genomic View for ANKK1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ANKK1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANKK1 Gene

Proteins for ANKK1 Gene

  • Protein details for ANKK1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NFD2-ANKK1_HUMAN
    Recommended name:
    Ankyrin repeat and protein kinase domain-containing protein 1
    Protein Accession:
    Q8NFD2
    Secondary Accessions:

    Protein attributes for ANKK1 Gene

    Size:
    765 amino acids
    Molecular mass:
    84632 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ANKK1 Gene

Proteomics data for ANKK1 Gene at MOPED

Selected DME Specific Peptides for ANKK1 Gene

Post-translational modifications for ANKK1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ANKK1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for ANKK1 Gene

Gene Families for ANKK1 Gene

Suggested Antigen Peptide Sequences for ANKK1 Gene

Graphical View of Domain Structure for InterPro Entry

Q8NFD2

UniProtKB/Swiss-Prot:

ANKK1_HUMAN :
  • Q8NFD2
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.
Similarity:
  • Contains 12 ANK repeats.
genes like me logo Genes that share domains with ANKK1: view

Function for ANKK1 Gene

Molecular function for ANKK1 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein

Enzyme Numbers (IUBMB) for ANKK1 Gene

Gene Ontology (GO) - Molecular Function for ANKK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0004713 protein tyrosine kinase activity --
GO:0005515 protein binding --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with ANKK1: view
genes like me logo Genes that share phenotypes with ANKK1: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ANKK1

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ANKK1 Gene

Localization for ANKK1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ANKK1 Gene COMPARTMENTS Subcellular localization image for ANKK1 gene
Compartment Confidence
cytosol 3
cytoskeleton 2
nucleus 2
endoplasmic reticulum 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ANKK1 Gene

Pathways for ANKK1 Gene

SuperPathways for ANKK1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ANKK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
genes like me logo Genes that share ontologies with ANKK1: view

No data available for Pathways by source for ANKK1 Gene

Compounds for ANKK1 Gene

(11) PharmGKB related drug/compound annotations for ANKK1 Gene

genes like me logo Genes that share compounds with ANKK1: view

Transcripts for ANKK1 Gene

mRNA/cDNA for ANKK1 Gene

(4) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ANKK1 Gene

Ankyrin repeat and kinase domain containing 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ANKK1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for ANKK1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ANKK1 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8
SP1: -
SP2:

Relevant External Links for ANKK1 Gene

GeneLoc Exon Structure for
ANKK1
ECgene alternative splicing isoforms for
ANKK1

Expression for ANKK1 Gene

mRNA expression in normal human tissues for ANKK1 Gene

mRNA differential expression in normal tissues according to GTEx for ANKK1 Gene

This gene is overexpressed in Pituitary (5.5) and Skin - Sun Exposed (Lower leg) (4.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ANKK1 Gene

SOURCE GeneReport for Unigene cluster for ANKK1 Gene Hs.448473

mRNA Expression by UniProt/SwissProt for ANKK1 Gene

Q8NFD2-ANKK1_HUMAN
Tissue specificity: Highly expressed in brain and weakly expressed in placenta and spinal cord.
genes like me logo Genes that share expressions with ANKK1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for ANKK1 Gene

Orthologs for ANKK1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ANKK1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ANKK1 35
  • 98.65 (n)
  • 97.38 (a)
ANKK1 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ANKK1 35
  • 73.08 (n)
  • 64.82 (a)
ANKK1 36
  • 62 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ANKK1 35
  • 85.86 (n)
  • 82.61 (a)
ANKK1 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ankk1 35
  • 81.67 (n)
  • 79.54 (a)
Ankk1 16
Ankk1 36
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ANKK1 36
  • 73 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ankk1 35
  • 80.79 (n)
  • 79.08 (a)
chicken
(Gallus gallus)
Aves ANKK1 35
  • 67.7 (n)
  • 62.77 (a)
ANKK1 36
  • 58 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 20 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia ankk1 35
  • 57.9 (n)
  • 55.07 (a)
zebrafish
(Danio rerio)
Actinopterygii ankk1 35
  • 53.03 (n)
  • 42.88 (a)
ankk1 36
  • 41 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes AVO2 38
thale cress
(Arabidopsis thaliana)
eudicotyledons KEG 35
  • 41.44 (n)
  • 28.99 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 31 (a)
ManyToMany
-- 36
  • 27 (a)
ManyToMany
-- 36
  • 28 (a)
ManyToMany
Species with no ortholog for ANKK1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ANKK1 Gene

ENSEMBL:
Gene Tree for ANKK1 (if available)
TreeFam:
Gene Tree for ANKK1 (if available)

Paralogs for ANKK1 Gene

Paralogs for ANKK1 Gene

Selected SIMAP similar genes for ANKK1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ANKK1: view

Variants for ANKK1 Gene

Sequence variations from dbSNP and Humsavar for ANKK1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs1800497 Pathogenic, - 113,400,106(-) TGCCT(C/T)GACCA missense, reference
rs2587553 -- 113,399,748(-) GTCCA(A/G)CCCTG reference, synonymous-codon
rs2587554 -- 113,399,503(-) CAGCA(G/T)CTTGA missense, reference
rs2587555 -- 113,399,311(-) GTCCA(A/G)GAGCA reference, synonymous-codon
rs2734847 -- 113,400,343(-) TTGAT(A/C)TCAGG utr-variant-3-prime, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for ANKK1 Gene

Variant ID Type Subtype PubMed ID
nsv515795 CNV Loss 19592680

Relevant External Links for ANKK1 Gene

HapMap Linkage Disequilibrium report
ANKK1
Human Gene Mutation Database (HGMD)
ANKK1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANKK1 Gene

Disorders for ANKK1 Gene

Relevant External Links for ANKK1

Genetic Association Database (GAD)
ANKK1
Human Genome Epidemiology (HuGE) Navigator
ANKK1
genes like me logo Genes that share disorders with ANKK1: view

No data available for UniProtKB/Swiss-Prot for ANKK1 Gene

Publications for ANKK1 Gene

  1. Identification and characterization of ANKK1: a novel kinase gene closely linked to DRD2 on chromosome band 11q23.1. (PMID: 15146457) Neville M.J. … Walton R.T. (Hum. Mutat. 2004) 2 3 4 23
  2. The 3' region of the DRD2 gene is involved in genetic susceptibility to schizophrenia. (PMID: 14741327) Dubertret C. … Gorwood P. (Schizophr. Res. 2004) 3 4 23
  3. Family-based association analyses of alcohol dependence phenotypes across DRD2 and neighboring gene ANKK1. (PMID: 17850642) Dick D.M. … Goate A. (Alcohol. Clin. Exp. Res. 2007) 3 23 48
  4. Single nucleotide polymorphisms in ANKK1 and the dopamine D2 receptor gene affect cognitive outcome shortly after traumatic brain injury: a replication and extension study. (PMID: 18698520) McAllister T.W. … Tsongalis G.J. (Brain Inj 2008) 3 23 48
  5. Genetic diagnostics of functional variants of the human dopamine D2 receptor gene. (PMID: 19512960) Doehring A. … LAPtsch J. (Psychiatr. Genet. 2009) 3 23 48

Products for ANKK1 Gene

Sources for ANKK1 Gene

Back to Top

Content