Aliases for ANKK1 Gene
Aliases for ANKK1 Gene
External Ids for ANKK1 Gene
- HGNC: 21027
- Entrez Gene: 255239
- Ensembl: ENSG00000170209
- OMIM: 608774
- UniProtKB: Q8NFD2
Previous GeneCards Identifiers for ANKK1 Gene
- GC11P113292
- GC11P112796
- GC11P112763
- GC11P109186
- GC11P113258
Summaries for ANKK1 Gene
-
The protein encoded by this gene belongs to the Ser/Thr protein kinase family, and protein kinase superfamily involved in signal transduction pathways. This gene is closely linked to DRD2 gene (GeneID:1813) on chr 11, and a well studied restriction fragment length polymorphism (RFLP) designated TaqIA, was originally associated with the DRD2 gene, however, later was determined to be located in exon 8 of ANKK1 gene (PMIDs: 18621654, 15146457), where it causes a nonconservative amino acid substitution. It is not clear if this gene plays any role in neuropsychiatric disorders previously associated with Taq1A RFLP. [provided by RefSeq, Sep 2009]
GeneCards Summary for ANKK1 Gene
ANKK1 (Ankyrin Repeat And Kinase Domain Containing 1) is a Protein Coding gene. Diseases associated with ANKK1 include Alexithymia and Impulse Control Disorder. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is RIPK4.
Additional gene information for ANKK1 Gene
- Monarch Initiative
- Search for ANKK1 at DataMed
- Search for ANKK1 at HumanCyc
No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANKK1 Gene
Genomics for ANKK1 Gene
GeneHancer (GH) Regulatory Elements for ANKK1 Gene
Regulatory Element Products
Genomic Locations for ANKK1 Gene
- chr11:113,386,038-113,400,418
- (GRCh38/hg38)
- Size:
- 14,381 bases
- Orientation:
- Plus strand
- chr11:113,258,513-113,271,140
- (GRCh37/hg19)
Genomic View for ANKK1 Gene
- Cytogenetic band:
-
- 11q23.2 by Ensembl
- 11q23.2 by Entrez Gene
- 11q23.2 by HGNC


RefSeq DNA sequence for ANKK1 Gene
Proteins for ANKK1 Gene
-
Protein details for ANKK1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8NFD2-ANKK1_HUMAN
- Recommended name:
- Ankyrin repeat and protein kinase domain-containing protein 1
- Protein Accession:
- Q8NFD2
Protein attributes for ANKK1 Gene
- Size:
- 765 amino acids
- Molecular mass:
- 84632 Da
- Quaternary structure:
- No Data Available
Protein Expression for ANKK1 Gene
Selected DME Specific Peptides for ANKK1 Gene
- Q8NFD2:
-
- KPGNILL
- LHLDLKP
Post-translational modifications for ANKK1 Gene
Other Protein References for ANKK1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for ANKK1
-
Abcam antibodies for ANKK1
- Invitrogen Antibodies for ANKK1
- Search GeneTex for Antibodies for ANKK1
Protein Products
-
OriGene Purified Proteins for ANKK1
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-
Abcam proteins for ANKK1
Assay Products
Domains & Families for ANKK1 Gene
Gene Families for ANKK1 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted intracellular proteins
Protein Domains for ANKK1 Gene
Suggested Antigen Peptide Sequences for ANKK1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q8NFD2UniProtKB/Swiss-Prot:
ANKK1_HUMAN :- Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.
- Family:
-
- Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.
Function for ANKK1 Gene
Molecular function for ANKK1 Gene
- UniProtKB/Swiss-Prot CatalyticActivity:
- ATP + a protein = ADP + a phosphoprotein.
Enzyme Numbers (IUBMB) for ANKK1 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004672 | protein kinase activity | IEA | -- |
GO:0004674 | protein serine/threonine kinase activity | IEA | -- |
GO:0005524 | ATP binding | IEA | -- |
GO:0016301 | kinase activity | IEA | -- |
GO:0016740 | transferase activity | IEA | -- |
Phenotypes for ANKK1 Gene
- GenomeRNAi human phenotypes for ANKK1:
-
- Increased vaccinia virus (VACV) infection
- shRNA abundance <= 50%
- Decreased ionizing radiation sensitivity
- Decreased viability ratio
- Decreased viability
- Decreased vesicular stomatitis virus (VSV) infection
- Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance
- Decreased influenza A/WSN/33 replication
- Weakly decreased NFAT1-GFP nuclear translocation
- Increased cell viability after pRB stimulation
- Decreased substrate adherent cell growth
- Decreased cell proliferation
Animal Model Products
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-
-
ViGene Biosciences lentiviral particle packaged cDNA for ANKK1 gene
-
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CRISPR Products
-
OriGene CRISPR knockouts for ANKK1
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-
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miRNA for ANKK1 Gene
- miRTarBase miRNAs that target ANKK1
miRNA Products
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Inhibitory RNA Products
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ViGene Biosciences ready-to-package AAV shRNAs for ANKK1 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for ANKK1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
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-
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No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ANKK1 Gene
Localization for ANKK1 Gene
No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for ANKK1 Gene
Pathways & Interactions for ANKK1 Gene
Interacting Proteins for ANKK1 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006468 | protein phosphorylation | IEA | -- |
GO:0016310 | phosphorylation | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for ANKK1 Gene
Drugs & Compounds for ANKK1 Gene
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Aripiprazole | Approved, Investigational | Pharma | Antagonist | Antipsychotic, High affinity D2 and 5-HT1A receptor partial agonist; also 5-HT2A antagonist | 373 | |
Bupropion | Approved | Pharma | 344 | |||
Clozapine | Approved | Pharma | Antagonist | Antipsychotic medication | 121 | |
Disulfiram | Approved | Pharma | Reversibly stimulates SERCA Ca2+-ATPase; displays a range of other activities | 41 | ||
Ethanol | Approved | Pharma | 2326 |
Transcripts for ANKK1 Gene
mRNA/cDNA for ANKK1 Gene
- (5) REFSEQ mRNAs :
- (2) Additional mRNA sequences :
- (3) Selected AceView cDNA sequences:
- (2) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for ANKK1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for ANKK1
- genomics-online: gRNA clones - Search results for 60 available ANKK1 gene related products
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-
Vectors and viruses for KO, Activation, Repression, and more
-
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miRNA Products
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Inhibitory RNA Products
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-
ViGene Biosciences ready-to-package AAV shRNAs for ANKK1 gene
Clone Products
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- VectorBuilder custom plasmid, inducible vectors for ANKK1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ANKK1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for ANKK1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | ||||||||||||||||||
SP2: |
Expression for ANKK1 Gene
mRNA differential expression in normal tissues according to GTEx for ANKK1 Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ANKK1 Gene
NURSA nuclear receptor signaling pathways regulating expression of ANKK1 Gene:
ANKK1SOURCE GeneReport for Unigene cluster for ANKK1 Gene:
Hs.448473mRNA Expression by UniProt/SwissProt for ANKK1 Gene:
Q8NFD2-ANKK1_HUMANEvidence on tissue expression from TISSUES for ANKK1 Gene
- Nervous system(2.3)
Primer Products
-
OriGene qPCR primer pairs for ANKK1
- genomics-online: primer clones - Search results for 60 available ANKK1 gene related products
- Overview of 60 available ANKK1 gene related products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for ANKK1 Gene
Orthologs for ANKK1 Gene
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | ANKK1 33 34 |
|
||
dog (Canis familiaris) |
Mammalia | ANKK1 33 34 |
|
||
mouse (Mus musculus) |
Mammalia | Ankk1 33 16 34 |
|
||
rat (Rattus norvegicus) |
Mammalia | Ankk1 33 |
|
||
cow (Bos Taurus) |
Mammalia | ANKK1 33 34 |
|
||
oppossum (Monodelphis domestica) |
Mammalia | ANKK1 34 |
|
OneToOne | |
chicken (Gallus gallus) |
Aves | ANKK1 33 34 |
|
||
lizard (Anolis carolinensis) |
Reptilia | -- 34 |
|
ManyToMany | |
tropical clawed frog (Silurana tropicalis) |
Amphibia | ankk1 33 |
|
||
zebrafish (Danio rerio) |
Actinopterygii | ankk1 33 34 |
|
||
baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | AVO2 36 |
|
|
|
thale cress (Arabidopsis thaliana) |
eudicotyledons | KEG 33 |
|
||
sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
ManyToMany | |
-- 34 |
|
ManyToMany | |||
-- 34 |
|
ManyToMany |
- Species where no ortholog for ANKK1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for ANKK1 Gene
(13) SIMAP similar genes for ANKK1 Gene using alignment to 3 proteins:
Variants for ANKK1 Gene
SNP ID | Clin | Chr 11 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1800497 | pathogenic, drug-response, Dopamine receptor d2, reduced brain density of, ethanol response - Toxicity/ADR, clozapine response - Toxicity/ADR, bupropion response - Efficacy, olanzapine response - Toxicity/ADR, antipsychotics response - Toxicity/ADR, risperidone response - Toxicity/ADR | 113,400,106(+) | G/A | coding_sequence_variant, missense_variant | |
VAR_040362 | A breast infiltrating ductal carcinoma sample | p.Lys347Thr | |||
VAR_040372 | A lung large cell carcinoma sample | p.Gln717Leu | |||
VAR_040373 | A lung squamous cell carcinoma sample | p.Arg736Leu | |||
VAR_040374 | A lung neuroendocrine carcinoma sample | p.Glu764Lys |
Additional Variant Information for ANKK1 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANKK1 Gene
Disorders for ANKK1 Gene
Disorder | Aliases | PubMed IDs |
---|---|---|
alexithymia |
|
|
impulse control disorder |
|
|
antisocial personality disorder |
|
|
taqi polymorphism |
|
|
heroin dependence |
|
|
Additional Disease Information for ANKK1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for ANKK1 Gene
Publications for ANKK1 Gene
- Identification and characterization of ANKK1: a novel kinase gene closely linked to DRD2 on chromosome band 11q23.1. (PMID: 15146457) Neville MJ … Walton RT (Human mutation 2004) 2 3 4 22 58
- Genetic diagnostics of functional variants of the human dopamine D2 receptor gene. (PMID: 19512960) Doehring A … Lötsch J (Psychiatric genetics 2009) 3 22 44 58
- Single nucleotide polymorphisms in ANKK1 and the dopamine D2 receptor gene affect cognitive outcome shortly after traumatic brain injury: a replication and extension study. (PMID: 18698520) McAllister TW … Tsongalis GJ (Brain injury 2008) 3 22 44 58
- Family-based association analyses of alcohol dependence phenotypes across DRD2 and neighboring gene ANKK1. (PMID: 17850642) Dick DM … Goate A (Alcoholism, clinical and experimental research 2007) 3 22 44 58
- The 3' region of the DRD2 gene is involved in genetic susceptibility to schizophrenia. (PMID: 14741327) Dubertret C … Gorwood P (Schizophrenia research 2004) 3 4 22 58
Products for ANKK1 Gene
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- Invitrogen Antibodies for ANKK1
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- VectorBuilder custom plasmid, inducible vectors for ANKK1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ANKK1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 39 available ANKK1 Antibodies ranked by validation data
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- antibodies-online: Search results for available ANKK1 related products ranked by validation data
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- ViGene Biosciences adenoviral particle packaged cDNA for ANKK1 gene
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Sources for ANKK1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
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- (114) diseasecard
- (115) NIH Rare Diseases
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- (119) Disease Ontology
- (120) Genetics Home Reference
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- (133) ENCODE
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- (135) Horizon
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- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
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- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew