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ANKK1 Gene

protein-coding GIFtS: 51
GCID: GC11P113258

Ankyrin Repeat And Kinase Domain Containing 1

See ANKK1-related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
Ankyrin Repeat And Kinase Domain Containing 1¹ ²		Ankyrin Repeat And Protein Kinase Domain-Containing Protein 1²
Protein Kinase PKK2² ³		sgK288²
Sugen Kinase 288² ³		SGK288³
PKK2² ³		SgK288³
X-kinase² ³		EC 2.7.11⁸
EC 2.7.11.1³ ⁸

External Ids:	HGNC: 21027¹	Entrez Gene: 255239²	Ensembl: ENSG00000170209⁷	OMIM: 608774⁵	UniProtKB: Q8NFD2³

Export aliases for ANKK1 gene to outside databases

Previous GC identifers: GC11P113292 GC11P112796 GC11P112763 GC11P109186

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ANKK1 Gene:

The protein encoded by this gene belongs to the Ser/Thr protein kinase family, and protein kinase superfamily

involved in signal transduction pathways. This gene is closely linked to DRD2 gene (GeneID:1813) on chr 11, and a

well studied restriction fragment length polymorphism (RFLP) designated TaqIA, was originally associated with the

DRD2 gene, however, later was determined to be located in exon 8 of ANKK1 gene (PMIDs: 18621654, 15146457), where

it causes a nonconservative amino acid substitution. It is not clear if this gene plays any role in

neuropsychiatric disorders previously associated with Taq1A RFLP. (provided by RefSeq, Sep 2009)

GeneCards Summary for ANKK1 Gene:

ANKK1 (ankyrin repeat and kinase domain containing 1) is a protein-coding gene. Diseases associated with ANKK1 include heroin dependence, and alexithymia. GO annotations related to this gene include protein serine/threonine kinase activity. An important paralog of this gene is RIPK3.

Gene Wiki entry for ANKK1 Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence at NCBI GenBank:

NC_000011.9 NT_033899.9 NC_018922.2

Regulatory elements:

Regulatory transcription factor binding sites in the ANKK1 gene promoter:
HFH-3 C/EBPbeta p53 AREB6 FOXI1 POU2F1 POU2F1b POU2F1a FOXJ2 (long isoform) FOXJ2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ANKK1 promoter sequence

Search Chromatin IP Primers for ANKK1

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ANKK1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q23.2 Ensembl cytogenetic band: 11q23.2 HGNC cytogenetic band: 11q23.2

ANKK1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ANKK1 gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11P113258: view genomic region (about GC identifiers)

Start:	113,258,513 bp from pter	End:	113,271,140 bp from pter
Size:	12,628 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

UniProtKB/Swiss-Prot: ANKK1_HUMAN, Q8NFD2 (See protein sequence)

Recommended Name: Ankyrin repeat and protein kinase domain-containing protein 1

Size: 765 amino acids; 84632 Da

Explore the universe of human proteins at neXtProt for ANKK1: NX_Q8NFD2

Explore proteomics data for ANKK1 at MOPED

Post-translational modifications:

Modification sites at neXtProt

Modification sites at PhosphoSitePlus

2 DME Specific Peptides for ANKK1 (Q8NFD2)

KPGNILL

LHLDLKP

See ANKK1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_848605.1

ENSEMBL proteins:

ENSP00000306678 ENSP00000445810

ANKK1 Human Recombinant Protein Products:

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	antibodies-online peptides for ANKK1

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

HGNC Gene Families:

ANKRD: Ankyrin repeat domain containing

IUPHAR Guide to PHARMACOLOGY protein family classification: ankyrin repeat and kinase domain containing 1

Receptor interacting protein kinase (RIPK) family

Selected InterPro protein domains (see all 6):

IPR011009 Kinase-like_dom

IPR008271 Ser/Thr_kinase_AS

IPR000719 Prot_kinase_dom

IPR002110 Ankyrin_rpt

IPR001245 Ser-Thr/Tyr_kinase_cat_dom

Graphical View of Domain Structure for InterPro Entry Q8NFD2

ProtoNet protein and cluster: Q8NFD2

UniProtKB/Swiss-Prot: ANKK1_HUMAN, Q8NFD2

Similarity: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family

Similarity: Contains 12 ANK repeats

Similarity: Contains 1 protein kinase domain

Find genes that share domains with ANKK1 About GenesLikeMe

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: ANKK1_HUMAN, Q8NFD2

Catalytic activity: ATP + a protein = ADP + a phosphoprotein

Enzyme Numbers (IUBMB): EC 2.7.11.1¹ ² EC 2.7.11²

Gene Ontology (GO): Selected molecular function terms (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004672	protein kinase activity	--	--
GO:0004674	protein serine/threonine kinase activity	IEA	--
GO:0004713	protein tyrosine kinase activity	--	--
GO:0005515	protein binding	--	--
GO:0005524	ATP binding	IEA	--

Find genes that share ontologies with ANKK1 About GenesLikeMe

Phenotypes:
4 GenomeRNAi human phenotypes for ANKK1:

Decreased focal adhesion (FA)

Decreased influenza A/WSN/33 r

Decreased substrate adherent c

Decreased viability

Animal Models:

genOway: Develop your customized and physiologically relevant rodent model for ANKK1

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Gene Editing
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANKK1

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
cytosol	3
cytoskeleton	2
nucleus	2
endoplasmic reticulum	1

About this image

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
About This Section

Custom Pathway & Disease-focused RT² Profiler PCR Arrays for ANKK1
Interactions:

GeneGlobe Interaction Network for ANKK1

Gene Ontology (GO): 1 biological process term: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006468	protein phosphorylation	--	--

Find genes that share ontologies with ANKK1 About GenesLikeMe

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for ANKK1

Selected PharmGKB related drug/compound annotations for ANKK1 gene (see all 11) About this table

Drug/compound	PharmGKB Annotation
Drugs used in nicotine dependence	CA
antipsychotics	CA
bupropion	CA
clozapine	CA
disulfiram	CA
ethanol	CA
methadone	CA
nemonapride	CA
nicotine	CA
olanzapine	CA

Find genes that share compounds with ANKK1 About GenesLikeMe

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
About This Section

REFSEQ mRNAs for ANKK1 gene:

NM_178510.1

Unigene Cluster for ANKK1:

Ankyrin repeat and kinase domain containing 1

Hs.448473 [show with all ESTs]

Unigene Representative Sequence: AJ541797

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000303941(uc001pny.3) ENST00000542948

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Additional mRNA sequence:

AF487542.1 AJ541797.2

1 DOTS entry:

DT.100736992

3 AceView cDNA sequences:

NM_178510 AF487542 AJ541797

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for ANKK1 About this scheme

ExUns:	1	^	2a	·	2b	^	3	^	4	^	5	^	6a	·	6b	^	7	^	8
SP1:							-
SP2:

ECgene alternative splicing isoforms for ANKK1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ANKK1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: --

About this image

ANKK1 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

ANKK1 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.448473

UniProtKB/Swiss-Prot: ANKK1_HUMAN, Q8NFD2

Tissue specificity: Highly expressed in brain and weakly expressed in placenta and spinal cord

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANKK1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for ANKK1 gene from Selected species (see all 13) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Ankk1^{1 , 5}	ankyrin repeat and kinase domain containing 1^{1, 5}	81.67(n)¹ 79.54(a)¹		9 (26.83 cM)⁵ 244859¹ NM_172922.3¹ NP_766510.1¹ 49415222⁵
chicken (Gallus gallus)	Aves	ANKK1¹	ankyrin repeat and kinase domain containing 1	67.7(n) 62.77(a)		100859406 XM_003642615.2 XP_003642663.2
lizard (Anolis carolinensis)	Reptilia	--	Uncharacterized protein	20(a)	many ↔ many	LGc(6849338-6872565)
tropical clawed frog (Xenopus tropicalis)	Amphibia	ankk1¹	ankyrin repeat and kinase domain containing 1	57.9(n) 55.07(a)		100493231 XM_002937826.2 XP_002937872.1
zebrafish (Danio rerio)	Actinopterygii	ankk1¹	ankyrin repeat and kinase domain containing 1	53.03(n) 42.88(a)		100170831 NM_001130665.1 NP_001124137.1
thale cress (Arabidopsis thaliana)	eudicotyledons	KEG¹	KEG	41.44(n) 28.99(a)		831197 NM_121356.2 NP_196857.2

ENSEMBL Gene Tree for ANKK1 (if available)
TreeFam Gene Tree for ANKK1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ANKK1 gene

RIPK3² RIPK4² RIPK1² RIPK2²

13 SIMAP similar genes for ANKK1 using alignment to 3 protein entries: ANKK1_HUMAN (see all proteins):

IkBa MARK4 NRARP DKFZp434B2328 PSMD10 PPP1R12A

CDKN2C CDKN2D dik ANKRD29 RIPK4 NUAK1

ANKDD1A

Find genes that share paralogs with ANKK1 About GenesLikeMe

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section

SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
VAR_040373⁴		A lung squamous cell carcinoma sample⁴	--	see VAR_040373	2	R L	mis⁴		0	--	--	--	--
VAR_040374⁴		A lung neuroendocrine carcinoma sample⁴	--	see VAR_040374	2	E K	mis⁴		0	--	--	--	--
VAR_040372⁴		A lung large cell carcinoma sample⁴	--	see VAR_040372	2	Q L	mis⁴		0	--	--	--	--
VAR_040362⁴		A breast infiltrating ductal carcinoma sample⁴	--	see VAR_040362	2	K T	mis⁴		0	--	--	--	--
rs1800497^1,2,,4	C,F,O,A,H	pathogenic¹	113134184(-)	`TGCCTC/TGACCA`	2	K E	mis¹		29		MN EU NA NS EA CSA WA	3658
rs34716641^1,2	C	--	109194688(+)	`TTTTT-/TTTTTT`	1	--	int¹		1		NA	2
rs139054194^1,2		--	113119975(+)	`TGACTC/TAGGCC`	1	--	us2k¹		0	--	--	--	--
rs184325306^1,2		--	113120075(+)	`GGCTGG/TTCACC`	1	--	us2k¹		0	--	--	--	--
rs189173179^1,2		--	113120263(+)	`AGCCAA/GAGCAA`	1	--	us2k¹		0	--	--	--	--
rs56947174^1,2	F	--	113120312(+)	`TCCTGC/TTCCTG`	1	--	us2k¹		1		WA	118

HapMap Linkage Disequilibrium report for ANKK1 (113258513 - 113271140 bp)

Structural Variations
Database of Genomic Variants (DGV) 1 variation for ANKK1: About this table

Variant ID	Type	Subtype	PubMed ID
nsv515795	CNV	Loss	19592680

Human Gene Mutation Database (HGMD): ANKK1

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing ANKK1

DNA2.0 Custom Variant and Variant Library Synthesis for ANKK1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

OMIM gene information: 608774 OMIM disorders: --

10 diseases for ANKK1:
About MalaCards

heroin dependence alexithymia dopamine receptor d2, reduced brain density of alcohol dependence

bipolar i disorder neuroleptic malignant syndrome antisocial personality disorder tardive dyskinesia

traumatic brain injury nicotine dependence

5 inferred disease relationships from the University of Copenhagen DISEASES database for ANKK1:

Nicotine dependence Alcohol dependence Antisocial personality disorder Alexithymia

Heroin dependence

Find genes that share disorders with ANKK1 About GenesLikeMe

Genetic Association Database (GAD): ANKK1
Human Genome Epidemiology (HuGE) Navigator: ANKK1 (39 documents)

Export disorders for ANKK1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ANKK1 gene, integrated from 10 sources (see all 92):
(articles sorted by number of sources associating them with ANKK1)

Utopia: connect your pdf to the dynamic
world of online information

Identification and characterization of ANKK1: a novel kinase gene closely linked to DRD2 on chromosome band 11q23.1. (PubMed id 15146457)^{1, 2, 3, 9} Neville M.J.... Walton R.T. (Hum. Mutat. 2004)
Family-based association analyses of alcohol dependence phenotypes across DRD2 and neighboring gene ANKK1. (PubMed id 17850642)^{1, 4, 9} Dick D.M....Goate A. (Alcohol. Clin. Exp. Res. 2007)
Single nucleotide polymorphisms in ANKK1 and the dopamine D2 receptor gene affect cognitive outcome shortly after traumatic brain injury: a replication and extension study. (PubMed id 18698520)^{1, 4, 9} McAllister T.W....Tsongalis G.J. (Brain Inj 2008)
Genetic diagnostics of functional variants of the human dopamine D2 receptor gene. (PubMed id 19512960)^{1, 4, 9} Doehring A....LAPtsch J. (Psychiatr. Genet. 2009)
The 3' region of the DRD2 gene is involved in genetic susceptibility to schizophrenia. (PubMed id 14741327)^{1, 2, 9} Dubertret C....Gorwood P. (Schizophr. Res. 2004)
Family-based analysis of genetic variation underlying psychosis-inducing effects of cannabis: sibling analysis and proband follow-up. (PubMed id 21041608)^{1, 4} van Winkel R. (Arch. Gen. Psychiatry 2011)
Genetic, personality, and environmental predictors of drug use in adolescents. (PubMed id 19717274)^{1, 4} Conner B.T....Noble E.P. (J Subst Abuse Treat 2010)
A genetic schizophrenia-susceptibility region located between the ANKK1 and DRD2 genes. (PubMed id 20138949)^{1, 4} Dubertret C....Gouya L. (amp 2010)
The D2 dopamine receptor gene variant C957T affects human fear conditioning and aversive priming. (PubMed id 19900188)^{1, 4} Huertas E....Hoenicka J. (Genes Brain Behav. 2010)
A large-scale candidate gene association study of age at menarche and age at natural menopause. (PubMed id 20734064)^{1, 4} He C....Hunter D.J. (Hum. Genet. 2010)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 255239	HGNC: 21027	AceView: ANKK1	Ensembl:ENSG00000170209	euGenes: HUgn255239
ECgene: ANKK1	H-InvDB: ANKK1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ANKK1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ANKK1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for ANKK1 gene:
Search GeneIP for patents involving ANKK1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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	EMD Millipore genomic analysis products

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	OriGene Antibodies for ANKK1		OriGene RNAi products in human, mouse, rat for ANKK1
	Browse OriGene qPCR primer pairs and template standards		OriGene Protein Over-expression Lysate for ANKK1
	OriGene Custom Mass Spec		OriGene clones in human, mouse for ANKK1
	OriGene qSTAR qPCR primer pairs in human, mouse for ANKK1		Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
	OriGene ORF clones in mouse, rat for ANKK1		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for ANKK1		OriGene Custom Protein Services for ANKK1

	Block miRNA regulation of human, mouse, rat ANKK1 using miScript Target Protectors		SeqTarget long-range PCR primers for resequencing ANKK1
	DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ANKK1		Predesigned siRNA for gene silencing in human, mouse, rat ANKK1
	QuantiFast Probe-based Assays in human, mouse, rat ANKK1		QuantiTect SYBR Green Assays in human, mouse, rat ANKK1
	Custom PCR Arrays for ANKK1		Search Chromatin IP Primers for ANKK1
	Pre-validated RT² qPCR Primer Assay in human, mouse, rat ANKK1		GeneGlobe Interaction Network for ANKK1
	Regulatory tfbs in ANKK1 promoter

	GenScript Custom Purified and Recombinant Proteins Services for ANKK1		GenScript cDNA clones with any tag delivered in your preferred vector for ANKK1
	GenScript Custom Assay Services for ANKK1		GenScript Custom overexpressing Cell Line Services for ANKK1
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	Vector-based siRNA and miRNA, Ready for Transfection		Gene Mutant Library, Variants up to 10^11
	Plasmid Preparation		Custom Peptide Services

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	Novus Tissue Slides
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	Gene Synthesis
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANKK1

	SwitchGear 3'UTR luciferase reporter plasmids for ANKK1
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ThermoFisher Antibodies for ANKK1

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ANKK1

Browse compounds at ApexBio

Search Addgene for plasmids for ANKK1

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genOway: Develop your customized and physiologically relevant rodent model for ANKK1

	antibodies-online antibodies for ANKK1 (25 products)
	antibodies-online kits for ANKK1 (4 products)
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	antibodies-online proteins for ANKK1 (2 products)

GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 2 Nov 2014 , 8 Jan 2015

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The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes ANKK1 gene at Home site.

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ANKK1 Gene

Ankyrin Repeat And Kinase Domain Containing 1

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ANKK1 Gene

Ankyrin Repeat And Kinase Domain Containing 1

Aliasesfor ANKK1 gene

Summariesfor ANKK1 gene

Genomic Viewsfor ANKK1 gene

Proteinsfor ANKK1 gene

ANKK1 Human Recombinant Protein Products:

ANKK1 Antibody Products:

ANKK1 Assay Products:

Domains /Familiesfor ANKK1 gene

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Localizationfor ANKK1 gene

Pathways & Interactionsfor ANKK1 gene

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Expression for ANKK1 gene

Orthologsfor ANKK1 gene

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Genomic Variantsfor ANKK1 gene

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Genome Databases showing ANKK1 gene

Other Databases showing ANKK1 gene

Specialized Databases showing ANKK1 gene

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Aliases
for ANKK1 gene

Summaries
for ANKK1 gene

Genomic Views
for ANKK1 gene

Proteins
for ANKK1 gene

Domains /
Families
for ANKK1 gene

Function
for ANKK1 gene

Localization
for ANKK1 gene

Pathways & Interactions
for ANKK1 gene

Drugs & Compounds
for ANKK1 gene

Transcripts
for ANKK1 gene

Expression
for ANKK1 gene

Orthologs
for ANKK1 gene

Paralogs
for ANKK1 gene

Genomic Variants
for ANKK1 gene

Disorders / Diseases
for ANKK1 gene

Publications
for ANKK1 gene

Intellectual Property
for ANKK1 gene

Products
for ANKK1 gene