ANKIB1 Gene
protein-coding GIFtS: 44
GCID: GC07P091875
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|
ankyrin repeat and IBR domain containing 1
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Aliases
for ANKIB1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Ankyrin Repeat And IBR Domain Containing 11 2 | | KIAA13861 3 | | DKFZP434A02251 | | Ankyrin Repeat And IBR Domain-Containing Protein 12 |
Export aliases for ANKIB1 gene to outside databasesPrevious GC identifers: GC07P091486 GC07P091519 GC07P091712 GC07P086483 |
Summaries
for ANKIB1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: AKIB1_HUMAN, Q9P2G1Function: Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specificE2 ubiquitin-conjugating enzymes and then transfers it to substrates (By similarity)
|
Genomic Views
for ANKIB1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000007.13 NC_018918.1 NT_007933.15 NT_079595.2
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ANKIB1 gene promoter:
c-Fos CREB AP-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for ANKIB1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ANKIB1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 7q21.2 Ensembl cytogenetic band: 7q21.2 HGNC cytogenetic band: 7q21.3ANKIB1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07P091875: view genomic region
(about GC identifiers)
Start:
|
91,875,548 bp from pter |
End:
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92,030,698 bp from pter |
Size:
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155,151 bases |
Orientation:
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plus strand |
1 alternative location:
| Chr7+,CRA_TCAG 91,204,781-91,359,905 |
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Proteins
for ANKIB1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: AKIB1_HUMAN, Q9P2G1 (See
protein sequence)Recommended Name: Ankyrin repeat and IBR domain-containing protein 1 Size: 1089 amino acids; 122002 Da
Caution: Lacks one Cys residue in the IBR-type zinc finger domain that is one of the conserved features of the family
Sequence caution: Sequence=AAH63861.1; Type=Erroneous initiation; Sequence=BAA91537.1; Type=Erroneous initiation;Sequence=BAA92624.1; Type=Erroneous initiation;
Secondary accessions: Q6GMS4 Q6P3S9 Q9NTD7 Q9NW49Explore the universe of human proteins at neXtProt for ANKIB1: NX_Q9P2G1
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9P2G1
ANKIB1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_061877.1
ENSEMBL proteins: ENSP00000265742 ENSP00000407002 ENSP00000407913 ENSP00000406644 ENSP00000396406
Human Recombinant Protein Products:
ANKIB1 Antibody Products:
Assay Products for ANKIB1: |
Protein
Domains /
Families
for ANKIB1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ANKIB1 for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry Q9P2G1ProtoNet protein and cluster: Q9P2G1 3 Blocks protein families: IPB001841 Zn-finger IPB002110 Ankyrin repeat signature IPB002867 Zn-finger
UniProtKB/Swiss-Prot: AKIB1_HUMAN, Q9P2G1Similarity: Belongs to the RBR familySimilarity: Contains 2 ANK repeatsSimilarity: Contains 1 IBR-type zinc fingerSimilarity: Contains 2 RING-type zinc fingersSimilarity: Contains 1 UIM (ubiquitin-interacting motif) repeat |
Function
for ANKIB1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: AKIB1_HUMAN, Q9P2G1Function: Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specificE2 ubiquitin-conjugating enzymes and then transfers it to substrates (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ANKIB1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ANKIB1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: ANKIB1 (NM_019004) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ANKIB1 | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ANKIB1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANKIB1 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005515 | protein binding |
IPI | -- | | GO:0008270 | zinc ion binding |
IEA | -- |
ANKIB1 for ontologies About GeneDecksing
|
Pathways & Interactions
for ANKIB1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ANKIB1
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
4 Interacting proteins for ANKIB1 (Q9P2G11, 3 ENSP000002657424) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for ANKIB1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ANKIB1
Search CenterWatch for drugs/clinical trials and news about ANKIB1 / AKIB1
|
Transcripts
for ANKIB1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ANKIB1 gene: NM_019004.1 Unigene Cluster for ANKIB1: Ankyrin repeat and IBR domain containing 1 Hs.741328 [show with all ESTs]Unigene Representative Sequence: NM_0190047 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000265742(uc003ulw.2 uc010lew.1) ENST00000442183 ENST00000439883
ENST00000486698 ENST00000413588 ENST00000422095 ENST00000465883
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ANKIB1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ANKIB1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ANKIB1 (NM_019004) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ANKIB1 | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ANKIB1 |
Additional cDNA sequence: AB037807.1 AK001179.1 AK025475.1 AK057685.1 AL137349.1 BC031483.1 BC041643.1 BC063861.1 BC073893.1 BC094865.1 14 DOTS entries: DT.118551 DT.95209943 DT.121092548 DT.121092589 DT.121092610 DT.95312670 DT.100037119 DT.40127269 DT.95272069 DT.100735832 DT.102830085 DT.91988039 DT.95272067 DT.99994418 24/325 AceView cDNA sequences (see all 325): BM467948 AI086710 AA261824 BX118952 AU123510 CA392041 AI039474 CB178643 BM665290 AI653648 AI982781 BU632176 AI288132 BE299708 AI869279 CA314514 N64378 AA764790 BF237578 BC031483 AI498966 BQ722805 AW207272 BQ006491
GeneLoc Exon Structure
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Expression
for ANKIB1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ANKIB1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAAAATGATC
About this image
See ANKIB1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ANKIB1
SOURCE GeneReport for Unigene cluster: Hs.741328
SABiosciences Expression via Pathway-Focused PCR Array including ANKIB1:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ANKIB1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ANKIB1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ANKIB1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ANKIB1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANKIB1 |
Orthologs
for ANKIB1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for ANKIB1 gene from 5/19 species (see all 19) About this table
ENSEMBL Gene Tree for ANKIB1 (if available)
TreeFam Gene Tree for ANKIB1 (if available) |
Paralogs
for ANKIB1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ANKIB1 gene
- CUL72 CUL92 ARIH12 ARIH22
2 SIMAP similar genes for ANKIB1 using alignment to 7 protein entries: AKIB1_HUMAN (see all proteins):TRIM59 LNX1
ANKIB1 for paralogs About GeneDecksing
|
Genomic Variants
for ANKIB1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 7 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ANKIB1 (91875548 - 92030698 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ANKIB1: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ANKIB1 |
|
Disorders
/ Diseases
for ANKIB1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ANKIB1 for disorders About GeneDecksing
1  disease for ANKIB1: About MalaCardsmalaria
Human Genome Epidemiology (HuGE) Navigator: ANKIB1 (1 document)
Export disorders for ANKIB1 gene to outside databases
|
Publications
for ANKIB1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ANKIB1 gene, integrated from 9 sources (see all 16):
(articles sorted by number of sources associating them with ANKIB1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)1, 2 Nagase T.... Ohara O. (2000)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- Strategy for comprehensive identification of human N-myristoylated proteins using an insect cell-free protein synthesis system. (PubMed id 20213681)2 Suzuki T.... Utsumi T. (2010)
- The Ubiquitin-interacting Motif Protein, S5a, Is Ubiquitinated by All Types of Ubiquitin Ligases by a Mechanism Different from Typical Substrate Recognition. (PubMed id 19240029)1 Uchiki T....Goldberg A.L. (2009)
- Phosphoproteome of resting human platelets. (PubMed id 18088087)2 Zahedi R.P.... Sickmann A. (2008)
|
External Searches for ANKIB1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ANKIB1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ANKIB1 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing ANKIB1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ANKIB1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ANKIB1 gene:
Search GeneIP for patents involving ANKIB1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ANKIB1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ANKIB1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ANKIB1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ANKIB1 | | | OriGene Protein Over-expression Lysate for ANKIB1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ANKIB1 | | OriGene 3'-UTR Clone for ANKIB1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ANKIB1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ANKIB1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for ANKIB1 | | OriGene Custom Protein Services for ANKIB1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ANKIB1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ANKIB1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ANKIB1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ANKIB1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ANKIB1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ANKIB1 |
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| | | | Search Tocris compounds for ANKIB1 |
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 | | | ANKIB1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANKIB1 |
|  |  |  | | | | ThermoFisher Antibody for ANKIB1 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ANKIB1 |
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