Aliases for ANKIB1 Gene
External Ids for ANKIB1 Gene
- HGNC: 22215
- Entrez Gene: 54467
- Ensembl: ENSG00000001629
- UniProtKB: Q9P2G1
Previous GeneCards Identifiers for ANKIB1 Gene
- GC07P091486
- GC07P091519
- GC07P091712
- GC07P091875
- GC07P086483
Summaries for ANKIB1 Gene
GeneCards Summary for ANKIB1 Gene
ANKIB1 (Ankyrin Repeat And IBR Domain Containing 1) is a Protein Coding gene. An important paralog of this gene is CUL9.
UniProtKB/Swiss-Prot for ANKIB1 Gene
-
Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates.
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANKIB1 Gene
Genomics for ANKIB1 Gene
Regulatory Elements for ANKIB1 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH07G092588 | 1.4 | ENCODE dbSUPER | 15 | +343.7 | 343655 | 2.3 | CREB3L1 AGO1 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC | RBM48 ANKIB1 PEX1 GATAD1 FAM133B GC07P092561 |
| GH07G092402 | 0.8 | Ensembl ENCODE | 14.8 | +157.1 | 157064 | 2.1 | CTCF HLF MAFG MAX REST MYC MAFK | KRIT1 ANKIB1 ERVW-1 CYP51A1 GC07P092389 TMBIM7P |
| GH07G092638 | 1.8 | FANTOM5 Ensembl ENCODE dbSUPER | 3.2 | +397.3 | 397258 | 10.3 | HDGF PKNOX1 SIN3A GATA2 ZNF143 FOS JUNB TBX21 MAFF PBX2 | CDK6 LOC101927497 FAM133B GATAD1 KRIT1 ANKIB1 SAMD9 GC07M092611 GC07M092702 RNU6-10P |
| GH07G092418 | 0.5 | FANTOM5 | 10.3 | +172.8 | 172819 | 0.1 | CTCF ZNF654 GATAD1 IKZF1 | ERVW-1 ANKIB1 KRIT1 LRRD1 TMBIM7P GC07P092389 |
| GH07G091945 | 1.1 | Ensembl ENCODE | 4.5 | -300.1 | -300134 | 2.1 | HDAC1 PKNOX1 FOXA2 ZSCAN9 RARA ZNF121 RELB IKZF2 CEBPB PBX2 | CYP51A1 MTERF1 ANKIB1 GC07M091897 GC07P091998 |
- Transcription factor binding sites by QIAGEN in the ANKIB1 gene promoter:
Regulatory Element Products
Genomic Location for ANKIB1 Gene
- Chromosome:
- 7
- Start:
- 92,246,216 bp from pter
- End:
- 92,401,770 bp from pter
- Size:
- 155,555 bases
- Orientation:
- Plus strand
Genomic View for ANKIB1 Gene
- Cytogenetic band:
-
- 7q21.2 by Ensembl
- 7q21.2 by Entrez Gene
- 7q21.2 by HGNC
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ANKIB1 Gene
Proteins for ANKIB1 Gene
-
Protein details for ANKIB1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9P2G1-AKIB1_HUMAN
- Recommended name:
- Ankyrin repeat and IBR domain-containing protein 1
- Protein Accession:
- Q9P2G1
- Q6GMS4
- Q6P3S9
- Q9NTD7
- Q9NW49
Protein attributes for ANKIB1 Gene
- Size:
- 1089 amino acids
- Molecular mass:
- 122002 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=AAH63861.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA91537.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA92624.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Protein Expression for ANKIB1 Gene
Post-translational modifications for ANKIB1 Gene
Other Protein References for ANKIB1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for ANKIB1
- Invitrogen Antibodies for ANKIB1
- Search GeneTex for Antibodies for ANKIB1
Protein Products
-
OriGene Purified Proteins for ANKIB1
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- Origene Custom Protein Services for ANKIB1
- Search GeneTex for Proteins for ANKIB1
Assay Products
- antibodies-online Kits for ANKIB1: See all 9
No data available for DME Specific Peptides for ANKIB1 Gene
Domains & Families for ANKIB1 Gene
Gene Families for ANKIB1 Gene
Protein Domains for ANKIB1 Gene
Suggested Antigen Peptide Sequences for ANKIB1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9P2G1UniProtKB/Swiss-Prot:
AKIB1_HUMAN :- Members of the RBR family are atypical E3 ligases. They interact with the E2 conjugating enzyme UBE2L3 and function like HECT-type E3 enzymes: they bind E2s via the first RING domain, but require an obligate trans-thiolation step during the ubiquitin transfer, requiring a conserved cysteine residue in the second RING domain.
- Belongs to the RBR family.
- Domain:
-
- Members of the RBR family are atypical E3 ligases. They interact with the E2 conjugating enzyme UBE2L3 and function like HECT-type E3 enzymes: they bind E2s via the first RING domain, but require an obligate trans-thiolation step during the ubiquitin transfer, requiring a conserved cysteine residue in the second RING domain.
- Family:
-
- Belongs to the RBR family.
Function for ANKIB1 Gene
Molecular function for ANKIB1 Gene
- UniProtKB/Swiss-Prot CatalyticActivity:
- S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.
- UniProtKB/Swiss-Prot Function:
- Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates.
Enzyme Numbers (IUBMB) for ANKIB1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004842 | ubiquitin-protein transferase activity | IEA | -- |
| GO:0005515 | protein binding | IPI | 20195357 |
| GO:0008270 | zinc ion binding | IEA | -- |
| GO:0016740 | transferase activity | IEA | -- |
| GO:0031624 | ubiquitin conjugating enzyme binding | IBA | -- |
Phenotypes for ANKIB1 Gene
- MGI mutant phenotypes for ANKIB1:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for ANKIB1:
Animal Models for ANKIB1 Gene
- MGI Knock Outs for ANKIB1:
-
- Ankib1 tm1b(EUCOMM)Hmgu
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for ANKIB1
-
-
ViGene Biosciences lentiviral particle packaged cDNA for ANKIB1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for ANKIB1 gene
- Search ViGene Biosciences for ANKIB1
CRISPR Products
-
OriGene CRISPR knockouts for ANKIB1
-
Santa Cruz Biotechnology (SCBT) CRISPR for ANKIB1
- GenScript: Design CRISPR guide RNA sequences for ANKIB1
miRNA for ANKIB1 Gene
- miRTarBase miRNAs that target ANKIB1
-
- hsa-mir-1-3p (MIRT002805)
- hsa-mir-335-5p (MIRT018457)
- hsa-mir-25-3p (MIRT050234)
- hsa-mir-17-5p (MIRT104391)
- hsa-mir-19a-3p (MIRT104392)
- hsa-mir-19b-3p (MIRT104393)
- hsa-mir-20a-5p (MIRT104394)
- hsa-mir-93-5p (MIRT104397)
- hsa-mir-106b-5p (MIRT104400)
- hsa-mir-20b-5p (MIRT104403)
- hsa-mir-519d-3p (MIRT104408)
- hsa-mir-32-5p (MIRT171644)
- hsa-mir-92a-3p (MIRT171645)
- hsa-mir-92b-3p (MIRT171661)
- hsa-mir-3185 (MIRT621026)
- hsa-mir-5582-3p (MIRT621027)
miRNA Products
- Search ViGene Biosciences for ANKIB1
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for ANKIB1
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-
ViGene Biosciences ready-to-package AAV shRNAs for ANKIB1 gene
Clone Products
-
OriGene ORF clones in human for ANKIB1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- VectorBuilder custom plasmid, inducible vectors for ANKIB1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ANKIB1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for ANKIB1
-
ViGene Biosciences adenoviral particle packaged cDNA for ANKIB1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for ANKIB1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for ANKIB1 gene
Flow Cytometry Products
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ANKIB1 Gene
Localization for ANKIB1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000151 | ubiquitin ligase complex | IBA | -- |
| GO:0005737 | cytoplasm | IBA | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for ANKIB1 Gene
Pathways & Interactions for ANKIB1 Gene
Interacting Proteins for ANKIB1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000209 | protein polyubiquitination | IBA | -- |
| GO:0016567 | protein ubiquitination | IEA | -- |
| GO:0032436 | positive regulation of proteasomal ubiquitin-dependent protein catabolic process | IBA | -- |
| GO:0042787 | protein ubiquitination involved in ubiquitin-dependent protein catabolic process | IBA | -- |
No data available for Pathways by source and SIGNOR curated interactions for ANKIB1 Gene
Transcripts for ANKIB1 Gene
mRNA/cDNA for ANKIB1 Gene
- (6) REFSEQ mRNAs :
- (10) Additional mRNA sequences :
- (325) Selected AceView cDNA sequences:
- (7) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for ANKIB1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for ANKIB1
-
Santa Cruz Biotechnology (SCBT) CRISPR for ANKIB1
- GenScript: Design CRISPR guide RNA sequences for ANKIB1
miRNA Products
- Search ViGene Biosciences for ANKIB1
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for ANKIB1
- Browse OriGene Inhibitory RNA Products For ANKIB1
-
ViGene Biosciences ready-to-package AAV shRNAs for ANKIB1 gene
Clone Products
-
OriGene ORF clones in human for ANKIB1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- VectorBuilder custom plasmid, inducible vectors for ANKIB1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ANKIB1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
Expression for ANKIB1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Testis (Reproductive System)
- Leydig Cells Testis Interstitium
- Brain (Nervous System)
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ANKIB1 Gene
NURSA nuclear receptor signaling pathways regulating expression of ANKIB1 Gene:
ANKIB1SOURCE GeneReport for Unigene cluster for ANKIB1 Gene:
Hs.83293Evidence on tissue expression from TISSUES for ANKIB1 Gene
- Nervous system(4.8)
- Skin(4.3)
- Blood(4.1)
- Liver(4.1)
Primer Products
-
OriGene qPCR primer pairs for ANKIB1
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ANKIB1 Gene
Orthologs for ANKIB1 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ANKIB1 35 34 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | ANKIB1 34 |
|
||
| cow (Bos Taurus) |
Mammalia | ANKIB1 35 34 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | ANKIB1 35 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Ankib1 16 35 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Ankib1 34 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 35 |
|
OneToMany | |
| -- 35 |
|
OneToMany | |||
| -- 35 |
|
OneToMany | |||
| chicken (Gallus gallus) |
Aves | ANKIB1 35 34 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | ANKIB1 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | ankib1 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | ankib1a 35 |
|
OneToMany | |
| ankib1b 35 |
|
OneToMany | |||
| ankib1 34 |
|
||||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | -- 35 |
|
OneToMany | |
| thale cress (Arabidopsis thaliana) |
eudicotyledons | ARI5 34 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os04g0492100 34 |
|
- Species where no ortholog for ANKIB1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for ANKIB1 Gene
(3) SIMAP similar genes for ANKIB1 Gene using alignment to 7 proteins:
Variants for ANKIB1 Gene
| SNP ID | Clin | Chr 07 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs117169559 | Likely benign | 92,245,107(+) | TTGGA(C/T)CACCG | intron-variant, upstream-variant-2KB, utr-variant-5-prime | |
| rs143215997 | Likely benign | 92,246,005(+) | CCTGC(C/T)CCTTT | upstream-variant-2KB, utr-variant-5-prime | |
| rs553392669 | Likely benign | 92,246,017(+) | CACTG(A/G)ACCTG | upstream-variant-2KB, utr-variant-5-prime | |
| rs570721041 | Likely benign | 92,245,600(+) | CCTGG(A/C)GAGGG | intron-variant, upstream-variant-2KB, utr-variant-5-prime | |
| rs571563061 | Likely benign | 92,245,894(+) | TTCCA(A/C/G)CCCGC | intron-variant, upstream-variant-2KB, utr-variant-5-prime |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2677331 | CNV | deletion | 23128226 |
| esv2734819 | CNV | deletion | 23290073 |
| esv3614138 | CNV | loss | 21293372 |
Relevant External Links for ANKIB1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- ANKIB1
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANKIB1 Gene
Disorders for ANKIB1 Gene
Relevant External Links for ANKIB1
No disorders were found for ANKIB1 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANKIB1 Gene
Publications for ANKIB1 Gene
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 64
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
- Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T. … Ohara O. (DNA Res. 2000) 3 4 64
Products for ANKIB1 Gene
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- Horizon Cell Lines for ANKIB1
- Cyagen custom Knockout/knockin (KOKI) mouse models for ANKIB1
- VectorBuilder custom plasmid, inducible vectors for ANKIB1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ANKIB1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for ANKIB1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
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- (15) Blocks
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- (21) IntAct
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- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
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- (59) MILLIPORE
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- (62) NCBI
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- (64) PubMed
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- (66) TGDB
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- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
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- (100) COMPARTMENTS
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- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer




