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Aliases for ANKIB1 Gene

Aliases for ANKIB1 Gene

  • Ankyrin Repeat And IBR Domain Containing 1 2 3
  • KIAA1386 4

External Ids for ANKIB1 Gene

Summaries for ANKIB1 Gene

GeneCards Summary for ANKIB1 Gene

ANKIB1 (Ankyrin Repeat And IBR Domain Containing 1) is a Protein Coding gene. An important paralog of this gene is RNF19A.

UniProtKB/Swiss-Prot for ANKIB1 Gene

  • Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANKIB1 Gene

Genomics for ANKIB1 Gene

Genomic Location for ANKIB1 Gene

Start:
92,246,216 bp from pter
End:
92,401,384 bp from pter
Size:
155,169 bases
Orientation:
Plus strand

Genomic View for ANKIB1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ANKIB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANKIB1 Gene

Regulatory Elements for ANKIB1 Gene

Transcription factor binding sites by QIAGEN in the ANKIB1 gene promoter:

Proteins for ANKIB1 Gene

  • Protein details for ANKIB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P2G1-AKIB1_HUMAN
    Recommended name:
    Ankyrin repeat and IBR domain-containing protein 1
    Protein Accession:
    Q9P2G1
    Secondary Accessions:
    • Q6GMS4
    • Q6P3S9
    • Q9NTD7
    • Q9NW49

    Protein attributes for ANKIB1 Gene

    Size:
    1089 amino acids
    Molecular mass:
    122002 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH63861.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA91537.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA92624.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ANKIB1 Gene

Proteomics data for ANKIB1 Gene at MOPED

Post-translational modifications for ANKIB1 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys528 and Lys634

Other Protein References for ANKIB1 Gene

No data available for DME Specific Peptides for ANKIB1 Gene

Domains for ANKIB1 Gene

Gene Families for ANKIB1 Gene

HGNC:
  • ANKRD :Ankyrin repeat domain containing

Suggested Antigen Peptide Sequences for ANKIB1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9P2G1

UniProtKB/Swiss-Prot:

AKIB1_HUMAN
Domain:
  • Contains 1 UIM (ubiquitin-interacting motif) domain.:
    • Q9P2G1
Family:
  • Belongs to the RBR family.:
    • Q9P2G1
Similarity:
  • Contains 2 ANK repeats.:
    • Q9P2G1
  • Contains 1 IBR-type zinc finger.:
    • Q9P2G1
  • Contains 2 RING-type zinc fingers.:
    • Q9P2G1
genes like me logo Genes that share domains with ANKIB1: view

Function for ANKIB1 Gene

Molecular function for ANKIB1 Gene

UniProtKB/Swiss-Prot Function: Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates.

Gene Ontology (GO) - Molecular Function for ANKIB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20195357
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with ANKIB1: view

miRNA for ANKIB1 Gene

miRTarBase miRNAs that target ANKIB1

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ANKIB1 Gene

Localization for ANKIB1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ANKIB1 Gene COMPARTMENTS Subcellular localization image for ANKIB1 gene
Compartment Confidence
nucleus 3
cytosol 2
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ANKIB1 Gene

Pathways for ANKIB1 Gene

SuperPathways for ANKIB1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ANKIB1 Gene

None

No data available for Pathways by source for ANKIB1 Gene

Transcripts for ANKIB1 Gene

Unigene Clusters for ANKIB1 Gene

Ankyrin repeat and IBR domain containing 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ANKIB1 Gene

No ASD Table

Relevant External Links for ANKIB1 Gene

GeneLoc Exon Structure for
ANKIB1
ECgene alternative splicing isoforms for
ANKIB1

Expression for ANKIB1 Gene

mRNA expression in normal human tissues for ANKIB1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ANKIB1 Gene

SOURCE GeneReport for Unigene cluster for ANKIB1 Gene Hs.83293

genes like me logo Genes that share expressions with ANKIB1: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ANKIB1 Gene

Orthologs for ANKIB1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ANKIB1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ANKIB1 35
  • 99.82 (n)
  • 99.82 (a)
ANKIB1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ANKIB1 35
  • 92.06 (n)
  • 95.31 (a)
ANKIB1 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ANKIB1 35
  • 93.47 (n)
  • 96.51 (a)
mouse
(Mus musculus)
Mammalia Ankib1 35
  • 88.95 (n)
  • 93.35 (a)
Ankib1 16
Ankib1 36
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ANKIB1 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 78 (a)
OneToMany
-- 36
  • 88 (a)
OneToMany
-- 36
  • 82 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Ankib1 35
  • 88.73 (n)
  • 93.63 (a)
chicken
(Gallus gallus)
Aves ANKIB1 35
  • 81.74 (n)
  • 88.13 (a)
ANKIB1 36
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ANKIB1 36
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ankib1 35
  • 75.66 (n)
  • 82.81 (a)
zebrafish
(Danio rerio)
Actinopterygii ankib1 35
  • 70.81 (n)
  • 79.98 (a)
ankib1a 36
  • 75 (a)
OneToMany
ankib1b 36
  • 74 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 36
  • 25 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons ARI5 35
  • 46.89 (n)
  • 34 (a)
rice
(Oryza sativa)
Liliopsida Os04g0492100 35
  • 48.87 (n)
  • 37.94 (a)
Species with no ortholog for ANKIB1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ANKIB1 Gene

ENSEMBL:
Gene Tree for ANKIB1 (if available)
TreeFam:
Gene Tree for ANKIB1 (if available)

Paralogs for ANKIB1 Gene

Paralogs for ANKIB1 Gene

Selected SIMAP similar genes for ANKIB1 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with ANKIB1: view

Variants for ANKIB1 Gene

Sequence variations from dbSNP and Humsavar for ANKIB1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs2739 -- 92,400,995(-) CACAG(A/G)GCATT utr-variant-3-prime
rs10145 -- 92,401,104(-) TACAA(A/T)TTGGA utr-variant-3-prime
rs10946 -- 92,399,125(-) TTCCC(A/T)GTAAG utr-variant-3-prime
rs12740 -- 92,399,988(+) ATTCA(A/G)TAAAA utr-variant-3-prime
rs38793 -- 92,397,873(+) TCTGA(A/G)CAGCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ANKIB1 Gene

Variant ID Type Subtype PubMed ID
nsv888734 CNV Loss 21882294
nsv888735 CNV Loss 21882294
esv2734819 CNV Deletion 23290073
esv2677331 CNV Deletion 23128226

Relevant External Links for ANKIB1 Gene

HapMap Linkage Disequilibrium report
ANKIB1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANKIB1 Gene

Disorders for ANKIB1 Gene

Relevant External Links for ANKIB1

Genetic Association Database (GAD)
ANKIB1
Human Genome Epidemiology (HuGE) Navigator
ANKIB1
genes like me logo Genes that share disorders with ANKIB1: view

No data available for UniProtKB/Swiss-Prot for ANKIB1 Gene

Publications for ANKIB1 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  2. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T. … Ohara O. (DNA Res. 2000) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4

Products for ANKIB1 Gene

Sources for ANKIB1 Gene

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