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Aliases for ANKHD1-EIF4EBP3 Gene

Aliases for ANKHD1-EIF4EBP3 Gene

  • ANKHD1-EIF4EBP3 Readthrough 2 3 5
  • MASK-4E-BP3 Alternate Reading Frame 3
  • MASK-BP3ARF 3
  • MASK-BP3 3

External Ids for ANKHD1-EIF4EBP3 Gene

Previous GeneCards Identifiers for ANKHD1-EIF4EBP3 Gene

  • GC05P139767
  • GC05P139782
  • GC05P140466
  • GC05P140470

Summaries for ANKHD1-EIF4EBP3 Gene

Entrez Gene Summary for ANKHD1-EIF4EBP3 Gene

  • The ANKHD1-EIF4EBP3 mRNA is an infrequent but naturally occurring readthrough transcript of the neighboring ANKHD1 and EIF4EBP3 genes. This readthrough transcript encodes a protein composed mostly of the multiple ankyrin repeats, single KH-domain protein, with its C-terminus encoded in a different reading frame from the shared portion of the EIF4EBP3 gene. The significance of this readthrough mRNA and the function of its protein product have not yet been determined. [provided by RefSeq, Nov 2009]

GeneCards Summary for ANKHD1-EIF4EBP3 Gene

ANKHD1-EIF4EBP3 (ANKHD1-EIF4EBP3 Readthrough) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is TANC1.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANKHD1-EIF4EBP3 Gene

Genomics for ANKHD1-EIF4EBP3 Gene

Regulatory Elements for ANKHD1-EIF4EBP3 Gene

Enhancers for ANKHD1-EIF4EBP3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ANKHD1-EIF4EBP3 on UCSC Golden Path with GeneCards custom track

Promoters for ANKHD1-EIF4EBP3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ANKHD1-EIF4EBP3 on UCSC Golden Path with GeneCards custom track

Genomic Location for ANKHD1-EIF4EBP3 Gene

Chromosome:
5
Start:
140,401,814 bp from pter
End:
140,549,578 bp from pter
Size:
147,765 bases
Orientation:
Plus strand

Genomic View for ANKHD1-EIF4EBP3 Gene

Genes around ANKHD1-EIF4EBP3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANKHD1-EIF4EBP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANKHD1-EIF4EBP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANKHD1-EIF4EBP3 Gene

Proteins for ANKHD1-EIF4EBP3 Gene

  • Protein details for ANKHD1-EIF4EBP3 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    H7C0V5
    Recommended name:
    Protein ANKHD1-EIF4EBP3
    Protein Accession:
    H7C0V5

    Protein attributes for ANKHD1-EIF4EBP3 Gene

    Size:
    636 amino acids
    Molecular mass:
    66134 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ANKHD1-EIF4EBP3 Gene

Proteomics data for ANKHD1-EIF4EBP3 Gene at MOPED

Protein Expression for ANKHD1-EIF4EBP3 Gene

Post-translational modifications for ANKHD1-EIF4EBP3 Gene

No Post-translational modifications

Other Protein References for ANKHD1-EIF4EBP3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ANKHD1-EIF4EBP3 Gene

Domains & Families for ANKHD1-EIF4EBP3 Gene

Protein Domains for ANKHD1-EIF4EBP3 Gene

ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ANKHD1-EIF4EBP3: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for ANKHD1-EIF4EBP3 Gene

Function for ANKHD1-EIF4EBP3 Gene

Gene Ontology (GO) - Molecular Function for ANKHD1-EIF4EBP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA --
genes like me logo Genes that share ontologies with ANKHD1-EIF4EBP3: view

Phenotypes for ANKHD1-EIF4EBP3 Gene

GenomeRNAi human phenotypes for ANKHD1-EIF4EBP3:
genes like me logo Genes that share phenotypes with ANKHD1-EIF4EBP3: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ANKHD1-EIF4EBP3 Gene

Localization for ANKHD1-EIF4EBP3 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for ANKHD1-EIF4EBP3 Gene

Pathways & Interactions for ANKHD1-EIF4EBP3 Gene

SuperPathways for ANKHD1-EIF4EBP3 Gene

No Data Available

Interacting Proteins for ANKHD1-EIF4EBP3 Gene

Gene Ontology (GO) - Biological Process for ANKHD1-EIF4EBP3 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ANKHD1-EIF4EBP3 Gene

Drugs & Compounds for ANKHD1-EIF4EBP3 Gene

No Compound Related Data Available

Transcripts for ANKHD1-EIF4EBP3 Gene

mRNA/cDNA for ANKHD1-EIF4EBP3 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for ANKHD1-EIF4EBP3 Gene

No ASD Table

Relevant External Links for ANKHD1-EIF4EBP3 Gene

GeneLoc Exon Structure for
ANKHD1-EIF4EBP3
ECgene alternative splicing isoforms for
ANKHD1-EIF4EBP3

Expression for ANKHD1-EIF4EBP3 Gene

mRNA expression in normal human tissues for ANKHD1-EIF4EBP3 Gene

Protein differential expression in normal tissues from HIPED for ANKHD1-EIF4EBP3 Gene

This gene is overexpressed in Lung (49.6) and Adipocyte (19.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from PaxDb for ANKHD1-EIF4EBP3 Gene



genes like me logo Genes that share expression patterns with ANKHD1-EIF4EBP3: view

Protein tissue co-expression partners for ANKHD1-EIF4EBP3 Gene

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ANKHD1-EIF4EBP3 Gene

Orthologs for ANKHD1-EIF4EBP3 Gene

This gene was present in the common ancestor of animals.

Orthologs for ANKHD1-EIF4EBP3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ANKHD1 35
  • 93.74 (n)
  • 96.54 (a)
EIF4EBP3 36
  • 96 (a)
OneToMany
dog
(Canis familiaris)
Mammalia ANKHD1 35
  • 94.25 (n)
  • 97.18 (a)
ANKHD1 36
  • 96 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Ankhd1 35
  • 89.9 (n)
  • 92.57 (a)
Ankhd1 16
Ankhd1 36
  • 92 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Ankhd1 35
  • 89.72 (n)
  • 92.56 (a)
oppossum
(Monodelphis domestica)
Mammalia ANKHD1 36
  • 89 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 91 (a)
OneToMany
chicken
(Gallus gallus)
Aves ANKHD1 35
  • 81.44 (n)
  • 87.11 (a)
ANKHD1 36
  • 85 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 82 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia ankhd1 35
  • 71.74 (n)
  • 74.36 (a)
zebrafish
(Danio rerio)
Actinopterygii ankhd1 35
  • 66.64 (n)
  • 74.95 (a)
ankhd1 36
  • 70 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta mask 36
  • 28 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 67 (a)
OneToMany
Species with no ortholog for ANKHD1-EIF4EBP3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ANKHD1-EIF4EBP3 Gene

ENSEMBL:
Gene Tree for ANKHD1-EIF4EBP3 (if available)
TreeFam:
Gene Tree for ANKHD1-EIF4EBP3 (if available)

Paralogs for ANKHD1-EIF4EBP3 Gene

Paralogs for ANKHD1-EIF4EBP3 Gene

(2) SIMAP similar genes for ANKHD1-EIF4EBP3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ANKHD1-EIF4EBP3: view

Variants for ANKHD1-EIF4EBP3 Gene

Sequence variations from dbSNP and Humsavar for ANKHD1-EIF4EBP3 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1137540 -- 140,542,438(+) cttgt(A/G)atccc intron-variant
rs1137541 -- 140,542,439(+) ttgta(A/G)tccca intron-variant
rs1137542 -- 140,542,444(+) atccc(A/G)gcact intron-variant
rs6860509 -- 140,544,268(+) CTCAT(C/T)TTTCT intron-variant
rs250432 -- 140,545,130(+) AAAAA(C/T)TCACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ANKHD1-EIF4EBP3 Gene

Variant ID Type Subtype PubMed ID
nsv509090 CNV Insertion 20534489
esv2418311 CNV Deletion 18987734
nsv330052 CNV Loss 16902084

Variation tolerance for ANKHD1-EIF4EBP3 Gene

Residual Variation Intolerance Score: 1.67% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ANKHD1-EIF4EBP3 Gene

Disorders for ANKHD1-EIF4EBP3 Gene

Relevant External Links for ANKHD1-EIF4EBP3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ANKHD1-EIF4EBP3

No disorders were found for ANKHD1-EIF4EBP3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANKHD1-EIF4EBP3 Gene

Publications for ANKHD1-EIF4EBP3 Gene

  1. Characterisation of a new splice variant of MASK-BP3(ARF) and MASK human genes, and their expression patterns during haematopoietic cell differentiation. (PMID: 16297570) Santos Duarte A.d.a. .S. … Saad S.T. (Gene 2005) 2 3 67
  2. Gene fusion and overlapping reading frames in the mammalian genes for 4E-BP3 and MASK. (PMID: 14557257) Poulin F. … Sonenberg N. (J. Biol. Chem. 2003) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta G.D. … Pelletier L. (Cell 2015) 3
  5. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3

Products for ANKHD1-EIF4EBP3 Gene

Sources for ANKHD1-EIF4EBP3 Gene

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