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Aliases for ANKHD1-EIF4EBP3 Gene

Aliases for ANKHD1-EIF4EBP3 Gene

  • ANKHD1-EIF4EBP3 Readthrough 2 3 5
  • MASK-4E-BP3 Alternate Reading Frame 3
  • ANKHD1-EIF4EBP3 Protein 3
  • MASK-BP3ARF 3
  • MASK-BP3 3

External Ids for ANKHD1-EIF4EBP3 Gene

Previous GeneCards Identifiers for ANKHD1-EIF4EBP3 Gene

  • GC05P139767
  • GC05P139782
  • GC05P140466
  • GC05P140470
  • GC05P140478
  • GC05P140487
  • GC05P140493

Summaries for ANKHD1-EIF4EBP3 Gene

Entrez Gene Summary for ANKHD1-EIF4EBP3 Gene

  • The ANKHD1-EIF4EBP3 mRNA is an infrequent but naturally occurring readthrough transcript of the neighboring ANKHD1 and EIF4EBP3 genes. This readthrough transcript encodes a protein composed mostly of the multiple ankyrin repeats, single KH-domain protein, with its C-terminus encoded in a different reading frame from the shared portion of the EIF4EBP3 gene. The significance of this readthrough mRNA and the function of its protein product have not yet been determined. [provided by RefSeq, Nov 2009]

GeneCards Summary for ANKHD1-EIF4EBP3 Gene

ANKHD1-EIF4EBP3 (ANKHD1-EIF4EBP3 Readthrough) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is ANKHD1.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANKHD1-EIF4EBP3 Gene

Genomics for ANKHD1-EIF4EBP3 Gene

Regulatory Elements for ANKHD1-EIF4EBP3 Gene

Enhancers for ANKHD1-EIF4EBP3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05G140563 1.1 ENCODE 10.7 +163.1 163113 3.1 HDGF PKNOX1 CREB3L1 ARNT AGO1 WRNIP1 ARID4B SIN3A YBX1 ZNF2 CD14 WDR55 DND1 ENSG00000200051 ANKHD1 ANKHD1-EIF4EBP3 ENSG00000253965 IK PFDN1 PCDHB16
GH05G140568 1 Ensembl ENCODE 10.7 +167.5 167542 2.6 PKNOX1 CBFB HLF MNT EBF1 RELA ZKSCAN1 POLR2A GLIS1 IKZF1 CD14 SRA1 TMCO6 EIF4EBP3 WDR55 DND1 ENSG00000200051 ANKHD1 ANKHD1-EIF4EBP3 IK
GH05G140566 0.6 ENCODE 10.7 +165.1 165113 0.0 ARID1B TCF12 MTA2 NCOR1 TAL1 IKZF1 ZBTB40 ENSG00000200051 ANKHD1 ANKHD1-EIF4EBP3 WDR55 DND1 APBB3 GC05P142006
GH05G140399 1.2 ENCODE 0.7 +0.2 215 4.7 CREB3L1 AGO1 ZFP64 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC TBX21 PURA PCDHA2 SRA1 CD14 PCDHA1 PCDHGA6 HARS EIF4EBP3 PCDHA3 PCDHA5
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ANKHD1-EIF4EBP3 on UCSC Golden Path with GeneCards custom track

Promoters for ANKHD1-EIF4EBP3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000187791 -14 3201 MLX CREB3L1 AGO1 ZFP64 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC

Genomic Location for ANKHD1-EIF4EBP3 Gene

Chromosome:
5
Start:
140,401,814 bp from pter
End:
140,549,578 bp from pter
Size:
147,765 bases
Orientation:
Plus strand

Genomic View for ANKHD1-EIF4EBP3 Gene

Genes around ANKHD1-EIF4EBP3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANKHD1-EIF4EBP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANKHD1-EIF4EBP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANKHD1-EIF4EBP3 Gene

Proteins for ANKHD1-EIF4EBP3 Gene

  • Protein details for ANKHD1-EIF4EBP3 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    H7C0V5
    Recommended name:
    ANKHD1-EIF4EBP3 readthrough
    Protein Accession:
    H7C0V5

    Protein attributes for ANKHD1-EIF4EBP3 Gene

    Size:
    636 amino acids
    Molecular mass:
    66134 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ANKHD1-EIF4EBP3 Gene

Protein Expression for ANKHD1-EIF4EBP3 Gene

Post-translational modifications for ANKHD1-EIF4EBP3 Gene

No Post-translational modifications

Other Protein References for ANKHD1-EIF4EBP3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ANKHD1-EIF4EBP3 Gene

Domains & Families for ANKHD1-EIF4EBP3 Gene

Protein Domains for ANKHD1-EIF4EBP3 Gene

ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ANKHD1-EIF4EBP3: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for ANKHD1-EIF4EBP3 Gene

Function for ANKHD1-EIF4EBP3 Gene

Phenotypes for ANKHD1-EIF4EBP3 Gene

GenomeRNAi human phenotypes for ANKHD1-EIF4EBP3:
genes like me logo Genes that share phenotypes with ANKHD1-EIF4EBP3: view

Animal Model Products

CRISPR Products

Clone Products

Cell Line Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ANKHD1-EIF4EBP3 Gene

Localization for ANKHD1-EIF4EBP3 Gene

Gene Ontology (GO) - Cellular Components for ANKHD1-EIF4EBP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with ANKHD1-EIF4EBP3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for ANKHD1-EIF4EBP3 Gene

Pathways & Interactions for ANKHD1-EIF4EBP3 Gene

SuperPathways for ANKHD1-EIF4EBP3 Gene

No Data Available

Interacting Proteins for ANKHD1-EIF4EBP3 Gene

Gene Ontology (GO) - Biological Process for ANKHD1-EIF4EBP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045087 innate immune response IBA --
genes like me logo Genes that share ontologies with ANKHD1-EIF4EBP3: view

No data available for Pathways by source and SIGNOR curated interactions for ANKHD1-EIF4EBP3 Gene

Drugs & Compounds for ANKHD1-EIF4EBP3 Gene

No Compound Related Data Available

Transcripts for ANKHD1-EIF4EBP3 Gene

mRNA/cDNA for ANKHD1-EIF4EBP3 Gene

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ANKHD1-EIF4EBP3 Gene

No ASD Table

Relevant External Links for ANKHD1-EIF4EBP3 Gene

GeneLoc Exon Structure for
ANKHD1-EIF4EBP3
ECgene alternative splicing isoforms for
ANKHD1-EIF4EBP3

Expression for ANKHD1-EIF4EBP3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ANKHD1-EIF4EBP3 Gene

Protein differential expression in normal tissues from HIPED for ANKHD1-EIF4EBP3 Gene

This gene is overexpressed in Lung (49.6) and Adipocyte (19.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from PaxDb and MOPED for ANKHD1-EIF4EBP3 Gene



Protein tissue co-expression partners for ANKHD1-EIF4EBP3 Gene

genes like me logo Genes that share expression patterns with ANKHD1-EIF4EBP3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ANKHD1-EIF4EBP3 Gene

Orthologs for ANKHD1-EIF4EBP3 Gene

This gene was present in the common ancestor of animals.

Orthologs for ANKHD1-EIF4EBP3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia EIF4EBP3 35
  • 96 (a)
OneToMany
ANKHD1 34
  • 93.74 (n)
dog
(Canis familiaris)
Mammalia ANKHD1 34 35
  • 94.25 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 91 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Ankhd1 16 35 34
  • 89.9 (n)
rat
(Rattus norvegicus)
Mammalia Ankhd1 34
  • 89.72 (n)
oppossum
(Monodelphis domestica)
Mammalia ANKHD1 35
  • 89 (a)
OneToMany
chicken
(Gallus gallus)
Aves ANKHD1 34 35
  • 81.44 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 82 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia ankhd1 34
  • 71.74 (n)
zebrafish
(Danio rerio)
Actinopterygii ankhd1 34 35
  • 66.64 (n)
fruit fly
(Drosophila melanogaster)
Insecta mask 35
  • 28 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 67 (a)
OneToMany
Species where no ortholog for ANKHD1-EIF4EBP3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ANKHD1-EIF4EBP3 Gene

ENSEMBL:
Gene Tree for ANKHD1-EIF4EBP3 (if available)
TreeFam:
Gene Tree for ANKHD1-EIF4EBP3 (if available)

Paralogs for ANKHD1-EIF4EBP3 Gene

(2) SIMAP similar genes for ANKHD1-EIF4EBP3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ANKHD1-EIF4EBP3: view

Variants for ANKHD1-EIF4EBP3 Gene

Sequence variations from dbSNP and Humsavar for ANKHD1-EIF4EBP3 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1000003066 -- 140,525,065(+) GAGCC(A/G)AGTTC intron-variant
rs1000003539 -- 140,475,096(+) TTTCT(A/G)TGTTA intron-variant
rs1000044560 -- 140,426,550(+) TCTTG(A/G)GTGTT intron-variant
rs1000066991 -- 140,500,617(+) CACTC(C/T)AGCAT intron-variant
rs1000103364 -- 140,472,644(+) TTGTT(C/T)ATCAA intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for ANKHD1-EIF4EBP3 Gene

Variant ID Type Subtype PubMed ID
esv2418311 CNV deletion 18987734
esv3606950 CNV loss 21293372
nsv1109730 CNV deletion 24896259
nsv330052 CNV deletion 16902084
nsv472329 CNV novel sequence insertion 20440878
nsv509090 CNV insertion 20534489

Variation tolerance for ANKHD1-EIF4EBP3 Gene

Residual Variation Intolerance Score: 1.67% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ANKHD1-EIF4EBP3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ANKHD1-EIF4EBP3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANKHD1-EIF4EBP3 Gene

Disorders for ANKHD1-EIF4EBP3 Gene

Relevant External Links for ANKHD1-EIF4EBP3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ANKHD1-EIF4EBP3

No disorders were found for ANKHD1-EIF4EBP3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANKHD1-EIF4EBP3 Gene

Publications for ANKHD1-EIF4EBP3 Gene

  1. Characterisation of a new splice variant of MASK-BP3(ARF) and MASK human genes, and their expression patterns during haematopoietic cell differentiation. (PMID: 16297570) Santos Duarte A.d.a. .S. … Saad S.T. (Gene 2005) 2 3 64
  2. Gene fusion and overlapping reading frames in the mammalian genes for 4E-BP3 and MASK. (PMID: 14557257) Poulin F. … Sonenberg N. (J. Biol. Chem. 2003) 2 3 64
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  4. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta G.D. … Pelletier L. (Cell 2015) 3 64
  5. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3 64

Products for ANKHD1-EIF4EBP3 Gene

Sources for ANKHD1-EIF4EBP3 Gene

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