Aliases for ANKHD1-EIF4EBP3 Gene
Aliases for ANKHD1-EIF4EBP3 Gene
External Ids for ANKHD1-EIF4EBP3 Gene
- HGNC: 33530
- Entrez Gene: 404734
- Ensembl: ENSG00000254996
Previous GeneCards Identifiers for ANKHD1-EIF4EBP3 Gene
- GC05P139767
- GC05P139782
- GC05P140466
- GC05P140470
- GC05P140478
- GC05P140487
- GC05P140493
Summaries for ANKHD1-EIF4EBP3 Gene
-
The ANKHD1-EIF4EBP3 mRNA is an infrequent but naturally occurring readthrough transcript of the neighboring ANKHD1 and EIF4EBP3 genes. This readthrough transcript encodes a protein composed mostly of the multiple ankyrin repeats, single KH-domain protein, with its C-terminus encoded in a different reading frame from the shared portion of the EIF4EBP3 gene. The significance of this readthrough mRNA and the function of its protein product have not yet been determined. [provided by RefSeq, Nov 2009]
GeneCards Summary for ANKHD1-EIF4EBP3 Gene
ANKHD1-EIF4EBP3 (ANKHD1-EIF4EBP3 Readthrough) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is ANKHD1.
No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANKHD1-EIF4EBP3 Gene
Genomics for ANKHD1-EIF4EBP3 Gene
Regulatory Elements for ANKHD1-EIF4EBP3 Gene
Enhancers for ANKHD1-EIF4EBP3 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH05G140563 | 1.1 | ENCODE | 10.7 | +163.1 | 163113 | 3.1 | HDGF PKNOX1 CREB3L1 ARNT AGO1 WRNIP1 ARID4B SIN3A YBX1 ZNF2 | CD14 WDR55 DND1 ENSG00000200051 ANKHD1 ANKHD1-EIF4EBP3 ENSG00000253965 IK PFDN1 PCDHB16 |
| GH05G140568 | 1 | Ensembl ENCODE | 10.7 | +167.5 | 167542 | 2.6 | PKNOX1 CBFB HLF MNT EBF1 RELA ZKSCAN1 POLR2A GLIS1 IKZF1 | CD14 SRA1 TMCO6 EIF4EBP3 WDR55 DND1 ENSG00000200051 ANKHD1 ANKHD1-EIF4EBP3 IK |
| GH05G140566 | 0.6 | ENCODE | 10.7 | +165.1 | 165113 | 0.0 | ARID1B TCF12 MTA2 NCOR1 TAL1 IKZF1 ZBTB40 | ENSG00000200051 ANKHD1 ANKHD1-EIF4EBP3 WDR55 DND1 APBB3 GC05P142006 |
| GH05G140399 | 1.2 | ENCODE | 0.7 | +0.2 | 215 | 4.7 | CREB3L1 AGO1 ZFP64 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC TBX21 | PURA PCDHA2 SRA1 CD14 PCDHA1 PCDHGA6 HARS EIF4EBP3 PCDHA3 PCDHA5 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around ANKHD1-EIF4EBP3 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for ANKHD1-EIF4EBP3 Gene
- Chromosome:
- 5
- Start:
- 140,401,814 bp from pter
- End:
- 140,549,578 bp from pter
- Size:
- 147,765 bases
- Orientation:
- Plus strand
Genomic View for ANKHD1-EIF4EBP3 Gene
Genes around ANKHD1-EIF4EBP3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 5q31.3 by Ensembl
- 5q31.3 by Entrez Gene
- 5q31.3 by HGNC
ANKHD1-EIF4EBP3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ANKHD1-EIF4EBP3 Gene
Proteins for ANKHD1-EIF4EBP3 Gene
-
Protein details for ANKHD1-EIF4EBP3 Gene (UniProtKB/TrEMBL)
- Protein Symbol:
- H7C0V5
- Recommended name:
- ANKHD1-EIF4EBP3 readthrough
- Protein Accession:
- H7C0V5
Protein attributes for ANKHD1-EIF4EBP3 Gene
- Size:
- 636 amino acids
- Molecular mass:
- 66134 Da
- Quaternary structure:
- No Data Available
Protein Expression for ANKHD1-EIF4EBP3 Gene
Post-translational modifications for ANKHD1-EIF4EBP3 Gene
No Post-translational modifications
Other Protein References for ANKHD1-EIF4EBP3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Search GeneTex for Antibodies for ANKHD1-EIF4EBP3
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for ANKHD1-EIF4EBP3
- Origene Custom Protein Services for ANKHD1-EIF4EBP3
- Search GeneTex for Proteins for ANKHD1-EIF4EBP3
Assay Products
No data available for DME Specific Peptides for ANKHD1-EIF4EBP3 Gene
Domains & Families for ANKHD1-EIF4EBP3 Gene
Protein Domains for ANKHD1-EIF4EBP3 Gene
- ProtoNet:
Graphical View of Domain Structure for InterPro Entry
No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for ANKHD1-EIF4EBP3 Gene
Function for ANKHD1-EIF4EBP3 Gene
Phenotypes for ANKHD1-EIF4EBP3 Gene
- GenomeRNAi human phenotypes for ANKHD1-EIF4EBP3:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for ANKHD1-EIF4EBP3
-
-
ViGene Biosciences ready-to-package AAV shRNAs for ANKHD1-EIF4EBP3 gene
- Search ViGene Biosciences for ANKHD1-EIF4EBP3
CRISPR Products
- Browse CRISPR knockouts for ANKHD1-EIF4EBP3
-
Santa Cruz Biotechnology (SCBT) CRISPR for ANKHD1-EIF4EBP3
- GenScript: Design CRISPR guide RNA sequences for ANKHD1-EIF4EBP3
miRNA for ANKHD1-EIF4EBP3 Gene
- miRTarBase miRNAs that target ANKHD1-EIF4EBP3
-
- hsa-mir-6838-5p (MIRT482766)
- hsa-mir-6834-5p (MIRT482767)
- hsa-mir-3622b-5p (MIRT482768)
- hsa-mir-885-3p (MIRT482769)
- hsa-mir-6134 (MIRT482770)
- hsa-mir-6133 (MIRT482771)
- hsa-mir-6130 (MIRT482772)
- hsa-mir-6129 (MIRT482773)
- hsa-mir-6127 (MIRT482774)
- hsa-mir-4510 (MIRT482775)
- hsa-mir-4419a (MIRT482776)
- hsa-mir-6875-5p (MIRT482777)
- hsa-mir-3126-5p (MIRT482778)
- hsa-mir-5693 (MIRT482779)
- hsa-mir-4519 (MIRT482780)
miRNA Products
- Search ViGene Biosciences for ANKHD1-EIF4EBP3
Inhibitory RNA Products
-
ViGene Biosciences ready-to-package AAV shRNAs for ANKHD1-EIF4EBP3 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for ANKHD1-EIF4EBP3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ANKHD1-EIF4EBP3
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for ANKHD1-EIF4EBP3
-
ViGene Biosciences adenoviral particle packaged cDNA for ANKHD1-EIF4EBP3 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for ANKHD1-EIF4EBP3 gene
- Search ViGene Biosciences for ANKHD1-EIF4EBP3
Flow Cytometry Products
No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ANKHD1-EIF4EBP3 Gene
Localization for ANKHD1-EIF4EBP3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IBA | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for ANKHD1-EIF4EBP3 Gene
Pathways & Interactions for ANKHD1-EIF4EBP3 Gene
No Data Available
Interacting Proteins for ANKHD1-EIF4EBP3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0045087 | innate immune response | IBA | -- |
No data available for Pathways by source and SIGNOR curated interactions for ANKHD1-EIF4EBP3 Gene
Transcripts for ANKHD1-EIF4EBP3 Gene
mRNA/cDNA for ANKHD1-EIF4EBP3 Gene
- (1) REFSEQ mRNAs :
- (365) Selected AceView cDNA sequences:
- (3) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
- Browse CRISPR knockouts for ANKHD1-EIF4EBP3
-
Santa Cruz Biotechnology (SCBT) CRISPR for ANKHD1-EIF4EBP3
- GenScript: Design CRISPR guide RNA sequences for ANKHD1-EIF4EBP3
miRNA Products
- Search ViGene Biosciences for ANKHD1-EIF4EBP3
Inhibitory RNA Products
-
ViGene Biosciences ready-to-package AAV shRNAs for ANKHD1-EIF4EBP3 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for ANKHD1-EIF4EBP3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ANKHD1-EIF4EBP3
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
Relevant External Links for ANKHD1-EIF4EBP3 Gene
- GeneLoc Exon Structure for
- ANKHD1-EIF4EBP3
- ECgene alternative splicing isoforms for
- ANKHD1-EIF4EBP3
Expression for ANKHD1-EIF4EBP3 Gene
This gene is overexpressed in Lung (49.6) and Adipocyte (19.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from PaxDb and MOPED for ANKHD1-EIF4EBP3 Gene
Primer Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ANKHD1-EIF4EBP3 Gene
Orthologs for ANKHD1-EIF4EBP3 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| cow (Bos Taurus) |
Mammalia | EIF4EBP3 35 |
|
OneToMany | |
| ANKHD1 34 |
|
||||
| dog (Canis familiaris) |
Mammalia | ANKHD1 34 35 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 35 |
|
OneToMany | |
| mouse (Mus musculus) |
Mammalia | Ankhd1 16 35 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Ankhd1 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | ANKHD1 35 |
|
OneToMany | |
| chicken (Gallus gallus) |
Aves | ANKHD1 35 34 |
|
OneToMany | |
| lizard (Anolis carolinensis) |
Reptilia | -- 35 |
|
OneToMany | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | ankhd1 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | ankhd1 34 35 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | mask 35 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
OneToMany |
- Species where no ortholog for ANKHD1-EIF4EBP3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chimpanzee (Pan troglodytes)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for ANKHD1-EIF4EBP3 Gene
- ENSEMBL:
- Gene Tree for ANKHD1-EIF4EBP3 (if available)
- TreeFam:
- Gene Tree for ANKHD1-EIF4EBP3 (if available)
Paralogs for ANKHD1-EIF4EBP3 Gene
Paralogs for ANKHD1-EIF4EBP3 Gene
(2) SIMAP similar genes for ANKHD1-EIF4EBP3 Gene using alignment to 1 proteins:
Variants for ANKHD1-EIF4EBP3 Gene
| SNP ID | Clin | Chr 05 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000003066 | -- | 140,525,065(+) | GAGCC(A/G)AGTTC | intron-variant | |
| rs1000003539 | -- | 140,475,096(+) | TTTCT(A/G)TGTTA | intron-variant | |
| rs1000044560 | -- | 140,426,550(+) | TCTTG(A/G)GTGTT | intron-variant | |
| rs1000066991 | -- | 140,500,617(+) | CACTC(C/T)AGCAT | intron-variant | |
| rs1000103364 | -- | 140,472,644(+) | TTGTT(C/T)ATCAA | intron-variant, downstream-variant-500B |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2418311 | CNV | deletion | 18987734 |
| esv3606950 | CNV | loss | 21293372 |
| nsv1109730 | CNV | deletion | 24896259 |
| nsv330052 | CNV | deletion | 16902084 |
| nsv472329 | CNV | novel sequence insertion | 20440878 |
| nsv509090 | CNV | insertion | 20534489 |
Residual Variation Intolerance Score:
1.67% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for ANKHD1-EIF4EBP3 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- ANKHD1-EIF4EBP3
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANKHD1-EIF4EBP3 Gene
Disorders for ANKHD1-EIF4EBP3 Gene
Relevant External Links for ANKHD1-EIF4EBP3
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- ANKHD1-EIF4EBP3
No disorders were found for ANKHD1-EIF4EBP3 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANKHD1-EIF4EBP3 Gene
Publications for ANKHD1-EIF4EBP3 Gene
- Characterisation of a new splice variant of MASK-BP3(ARF) and MASK human genes, and their expression patterns during haematopoietic cell differentiation. (PMID: 16297570) Santos Duarte A.d.a. .S. … Saad S.T. (Gene 2005) 2 3 64
- Gene fusion and overlapping reading frames in the mammalian genes for 4E-BP3 and MASK. (PMID: 14557257) Poulin F. … Sonenberg N. (J. Biol. Chem. 2003) 2 3 64
- The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
- A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta G.D. … Pelletier L. (Cell 2015) 3 64
- Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3 64
Products for ANKHD1-EIF4EBP3 Gene
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- Cyagen custom Knockout/knockin (KOKI) mouse models for ANKHD1-EIF4EBP3
- VectorBuilder custom plasmid, inducible vectors for ANKHD1-EIF4EBP3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ANKHD1-EIF4EBP3
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for ANKHD1-EIF4EBP3 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
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- (13) InterPro
- (14) ProtoNet
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- (21) IntAct
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- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
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- (62) NCBI
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- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
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- (96) MaxQB
- (97) IUPHAR
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- (100) COMPARTMENTS
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- (105) antibodies-online
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