Aliases for ANKFY1 Gene
Aliases for ANKFY1 Gene
External Ids for ANKFY1 Gene
- HGNC: 20763
- Entrez Gene: 51479
- Ensembl: ENSG00000185722
- OMIM: 607927
- UniProtKB: Q9P2R3
Previous GeneCards Identifiers for ANKFY1 Gene
- GC17M004410
- GC17M004019
- GC17M004273
- GC17M004013
- GC17M004066
Summaries for ANKFY1 Gene
-
This gene encodes a cytoplasmic protein that contains a coiled-coil structure and a BTB/POZ domain at its N-terminus, ankyrin repeats in the middle portion, and a FYVE-finger motif at its C-terminus. This protein belongs to a subgroup of double zinc finger proteins which may be involved in vesicle or protein transport. Alternate splicing results in multiple transcript variants of this gene. [provided by RefSeq, Apr 2012]
GeneCards Summary for ANKFY1 Gene
ANKFY1 (Ankyrin Repeat And FYVE Domain Containing 1) is a Protein Coding gene. GO annotations related to this gene include Rab GTPase binding and phosphatidylinositol phosphate binding. An important paralog of this gene is TRPA1.
UniProtKB/Swiss-Prot for ANKFY1 Gene
-
Proposed effector of Rab5. Binds to phosphatidylinositol 3-phosphate (PI(3)P). Involved in homotypic early endosome fusion and to a lesser extent in heterotypic fusion of chlathrin-coated vesicles with early endosomes. Involved in macropinocytosis; the function is dependent on Rab5-GTP. Required for correct endosomal localization. Involved in the internalization and trafficking of activated tyrosine kinase receptors such as PDGFRB. Regulates the subcellular localization of the retromer complex in a EHD1-dependent manner. Involved in endosome-to-Golgi transport and biosynthetic transport to late endosomes and lysosomes indicative for a regulation of retromer complex-mediated retrograde transport.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANKFY1 Gene
Genomics for ANKFY1 Gene
Regulatory Elements for ANKFY1 Gene
Enhancers for ANKFY1 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH17G004215 | 1.4 | Ensembl ENCODE dbSUPER | 11.4 | +48.2 | 48212 | 1.4 | CBX3 INSM2 SIN3A KLF17 DEAF1 FEZF1 ZNF2 ZSCAN9 RAD21 RFX5 | ANKFY1 CYB5D2 RYKP1 LOC100420060 |
| GH17G004373 | 1.5 | FANTOM5 Ensembl ENCODE | 10.6 | -111.1 | -111120 | 2.7 | HDGF TBP PKNOX1 TBL1XR1 WRNIP1 BMI1 YBX1 EGR1 SCRT2 ZNF207 | ANKFY1 CYB5D2 UBE2G1 GC17P004368 SPNS3 |
| GH17G004228 | 1.3 | Ensembl ENCODE dbSUPER | 11.7 | +34.0 | 33985 | 2.9 | TBP JUN INSM2 SIN3A FEZF1 ZEB1 RFX5 ZNF366 ZBTB48 ZSCAN5C | LOC100130950 ANKFY1 CYB5D2 RYKP1 |
| GH17G004340 | 1.3 | Ensembl ENCODE dbSUPER | 10.6 | -78.0 | -78019 | 3.3 | HDGF PKNOX1 WRNIP1 ZBTB40 YY1 ZNF121 ZNF366 ZSCAN5C ZNF600 PRDM10 | ANKFY1 CYB5D2 GC17M004334 RN7SL774P |
| GH17G004219 | 1.1 | ENCODE dbSUPER | 11.3 | +43.2 | 43199 | 1.7 | FOXA2 ZNF76 RARA ZNF366 ZSCAN5C CEBPB NR2F2 NFIC PRDM6 CEBPA | SHPK ANKFY1 CYB5D2 RYKP1 LOC100420060 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around ANKFY1 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for ANKFY1 Gene
- Chromosome:
- 17
- Start:
- 4,163,371 bp from pter
- End:
- 4,264,008 bp from pter
- Size:
- 100,638 bases
- Orientation:
- Minus strand
Genomic View for ANKFY1 Gene
Genes around ANKFY1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17p13.2 by Ensembl
- 17p13.2 by Entrez Gene
- 17p13.2 by HGNC
ANKFY1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ANKFY1 Gene
Proteins for ANKFY1 Gene
-
Protein details for ANKFY1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9P2R3-ANFY1_HUMAN
- Recommended name:
- Rabankyrin-5
- Protein Accession:
- Q9P2R3
- A8KA65
- Q5RKV4
- Q9ULG5
Protein attributes for ANKFY1 Gene
- Size:
- 1169 amino acids
- Molecular mass:
- 128399 Da
- Quaternary structure:
-
- Interacts with RAB5A (in GTP-bound form). Interacts with RHOD (independent of GTP-loaded status). Interacts with EHD1. Interacts with VPS26A; the interaction is indepenedent of EHD1 and is indicative for an association with the cargo recognition subcomplex of the retromer complex.
- SequenceCaution:
-
- Sequence=AAH52308.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305}; Sequence=BAA86569.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
Protein Expression for ANKFY1 Gene
Post-translational modifications for ANKFY1 Gene
Other Protein References for ANKFY1 Gene
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for ANKFY1
- Novus Biologicals Antibodies for ANKFY1
- Invitrogen Antibodies for ANKFY1
- antibodies-online Antibodies for ANKFY1: See all 23
- Search GeneTex for Antibodies for ANKFY1
-
Santa Cruz Biotechnology (SCBT) Antibodies for ANKFY1
Protein Products
-
OriGene Purified Proteins for ANKFY1
- Search Origene for MassSpec and Protein Over-expression Lysates for ANKFY1
- Origene Custom Protein Services for ANKFY1
- Search GeneTex for Proteins for ANKFY1
Assay Products
- antibodies-online Kits for ANKFY1: See all 11
No data available for DME Specific Peptides for ANKFY1 Gene
Domains & Families for ANKFY1 Gene
Gene Families for ANKFY1 Gene
Protein Domains for ANKFY1 Gene
Suggested Antigen Peptide Sequences for ANKFY1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for ANKFY1 Gene
Function for ANKFY1 Gene
Molecular function for ANKFY1 Gene
- UniProtKB/Swiss-Prot Function:
- Proposed effector of Rab5. Binds to phosphatidylinositol 3-phosphate (PI(3)P). Involved in homotypic early endosome fusion and to a lesser extent in heterotypic fusion of chlathrin-coated vesicles with early endosomes. Involved in macropinocytosis; the function is dependent on Rab5-GTP. Required for correct endosomal localization. Involved in the internalization and trafficking of activated tyrosine kinase receptors such as PDGFRB. Regulates the subcellular localization of the retromer complex in a EHD1-dependent manner. Involved in endosome-to-Golgi transport and biosynthetic transport to late endosomes and lysosomes indicative for a regulation of retromer complex-mediated retrograde transport.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 20562859 |
| GO:0017137 | Rab GTPase binding | IDA | 15328530 |
| GO:0046872 | metal ion binding | IEA | -- |
| GO:1901981 | phosphatidylinositol phosphate binding | IDA | 15328530 |
Phenotypes for ANKFY1 Gene
- GenomeRNAi human phenotypes for ANKFY1:
-
- Increased vaccinia virus (VACV) infection
- Increased gamma-H2AX phosphorylation
- Decreased viability
- Decreased hepcidin::fluc mRNA expression
- Decreased viability ratio
- Resistant to vaccinia virus (VACV-A4L) infection
- Increased transferrin (TF) endocytosis
- Negative genetic interaction between KRASG13D/+ and KRAS+/-
- Decreased shRNA abundance (Z-score < -2)
- Decreased IL-8 secretion
- Increased shRNA abundance (Z-score > 2)
- Decreased homologous recombination repair frequency
- Increased cell death HMECs cells
- Decreased cell number
- Increased epidermal growth factor receptor (EGFR) surface abundance
- Decreased Tat-dependent HIV-LTR-beta-galactosidase protein expression
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for ANKFY1
-
-
ViGene Biosciences lentiviral particle packaged cDNA for ANKFY1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for ANKFY1 gene
- Search ViGene Biosciences for ANKFY1
CRISPR Products
-
OriGene CRISPR knockouts for ANKFY1
-
Santa Cruz Biotechnology (SCBT) CRISPR for ANKFY1
- GenScript: Design CRISPR guide RNA sequences for ANKFY1
miRNA for ANKFY1 Gene
- miRTarBase miRNAs that target ANKFY1
-
- hsa-mir-155-5p (MIRT001572)
- hsa-mir-130b-3p (MIRT020203)
- hsa-mir-128-3p (MIRT022005)
- hsa-mir-1-3p (MIRT023719)
- hsa-mir-103a-3p (MIRT027089)
- hsa-mir-101-3p (MIRT027242)
- hsa-mir-93-5p (MIRT028043)
- hsa-mir-760 (MIRT036757)
- hsa-mir-106b-5p (MIRT044335)
- hsa-mir-4793-3p (MIRT145926)
- hsa-mir-7703 (MIRT145939)
- hsa-mir-374a-5p (MIRT197101)
- hsa-mir-374b-5p (MIRT197102)
- hsa-mir-4713-5p (MIRT375610)
- hsa-mir-218-5p (MIRT441231)
- hsa-mir-20a-5p (MIRT441232)
- hsa-mir-6720-5p (MIRT641006)
- hsa-mir-6512-3p (MIRT641007)
- hsa-mir-6729-5p (MIRT641008)
- hsa-mir-4649-5p (MIRT641009)
- hsa-mir-1273a (MIRT641010)
- hsa-mir-661 (MIRT641011)
- hsa-mir-4486 (MIRT641012)
- hsa-mir-2116-3p (MIRT641013)
- hsa-mir-532-3p (MIRT641014)
- hsa-mir-150-5p (MIRT641015)
- hsa-mir-766-3p (MIRT641016)
- hsa-mir-939-3p (MIRT641017)
- hsa-mir-186-3p (MIRT641018)
- hsa-mir-6849-3p (MIRT641019)
- hsa-mir-508-5p (MIRT641020)
- hsa-mir-576-5p (MIRT660643)
- hsa-mir-633 (MIRT660644)
- hsa-mir-4286 (MIRT660645)
- hsa-mir-877-3p (MIRT660646)
- hsa-mir-6513-5p (MIRT660647)
- hsa-mir-1224-3p (MIRT660648)
- hsa-mir-887-5p (MIRT660649)
- hsa-mir-3913-5p (MIRT660650)
- hsa-mir-3122 (MIRT660651)
- hsa-mir-450a-1-3p (MIRT660652)
- hsa-mir-6779-5p (MIRT660653)
- hsa-mir-6780a-5p (MIRT660654)
- hsa-mir-3689c (MIRT660655)
- hsa-mir-3689b-3p (MIRT660656)
- hsa-mir-3689a-3p (MIRT660657)
- hsa-mir-30b-3p (MIRT660658)
- hsa-mir-6788-5p (MIRT660659)
- hsa-mir-1273h-5p (MIRT660660)
- hsa-mir-30c-2-3p (MIRT660661)
- hsa-mir-7977 (MIRT660662)
- hsa-mir-30c-1-3p (MIRT660663)
- hsa-mir-654-5p (MIRT660664)
- hsa-mir-541-3p (MIRT660665)
- hsa-mir-920 (MIRT660666)
- hsa-mir-6726-5p (MIRT660667)
- hsa-mir-5591-5p (MIRT660668)
- hsa-mir-6090 (MIRT660669)
- hsa-mir-4300 (MIRT660670)
- hsa-mir-6827-5p (MIRT660671)
- hsa-mir-4761-5p (MIRT660672)
- hsa-mir-7855-5p (MIRT660673)
- hsa-mir-4710 (MIRT660674)
- hsa-mir-4792 (MIRT660675)
- hsa-mir-9-5p (MIRT660676)
- hsa-mir-6832-3p (MIRT660677)
- hsa-mir-6814-5p (MIRT660678)
- hsa-mir-3691-3p (MIRT660679)
- hsa-mir-2114-5p (MIRT660680)
- hsa-mir-6865-5p (MIRT660681)
- hsa-mir-6815-5p (MIRT660682)
- hsa-mir-211-5p (MIRT660683)
- hsa-mir-204-5p (MIRT660684)
- hsa-mir-3162-5p (MIRT705699)
- hsa-mir-3649 (MIRT705700)
- hsa-mir-7112-3p (MIRT705701)
- hsa-mir-107 (MIRT705702)
- hsa-mir-383-3p (MIRT705703)
- hsa-mir-34c-3p (MIRT705704)
- hsa-mir-4756-5p (MIRT705705)
- hsa-mir-4739 (MIRT705706)
- hsa-mir-1321 (MIRT705707)
- hsa-mir-6760-5p (MIRT705709)
- hsa-mir-193b-3p (MIRT728347)
- hsa-mir-519d-3p (MIRT728348)
- hsa-mir-193a-3p (MIRT728349)
- hsa-mir-20b-5p (MIRT728350)
- hsa-mir-17-5p (MIRT728351)
miRNA Products
- Search ViGene Biosciences for ANKFY1
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for ANKFY1
- Browse OriGene Inhibitory RNA Products For ANKFY1
-
ViGene Biosciences ready-to-package AAV shRNAs for ANKFY1 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for ANKFY1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ANKFY1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for ANKFY1
-
ViGene Biosciences adenoviral particle packaged cDNA for ANKFY1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for ANKFY1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for ANKFY1 gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ANKFY1 Gene
Localization for ANKFY1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ANKFY1 Gene
- Cytoplasm. Endosome membrane; Peripheral membrane protein. Early endosome. Note=Also associated with endosomal membranes. Localizes to macropinosomes. {ECO:0000269 PubMed:15328530}.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| lysosome | 5 |
| endosome | 5 |
| cytosol | 4 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005765 | lysosomal membrane | IDA | 17897319 |
| GO:0005768 | endosome | IDA | -- |
| GO:0005769 | early endosome | IDA,IEA | 15328530 |
| GO:0005829 | cytosol | IEA | -- |
Pathways & Interactions for ANKFY1 Gene
No Data Available
Interacting Proteins for ANKFY1 Gene
Selected Interacting proteins:
ENSP00000459775
Q9P2R3-ANFY1_HUMAN
for ANKFY1 Gene via
STRING
IID
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006897 | endocytosis | IEA | -- |
| GO:0032439 | endosome localization | IMP | 24102721 |
| GO:0034058 | endosomal vesicle fusion | IDA | 15328530 |
| GO:0042147 | retrograde transport, endosome to Golgi | IMP | 22284051 |
| GO:0048549 | positive regulation of pinocytosis | IDA | 15328530 |
No data available for Pathways by source and SIGNOR curated interactions for ANKFY1 Gene
Transcripts for ANKFY1 Gene
mRNA/cDNA for ANKFY1 Gene
- (9) REFSEQ mRNAs :
- (15) Additional mRNA sequences :
- (226) Selected AceView cDNA sequences:
- (13) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for ANKFY1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for ANKFY1
-
Santa Cruz Biotechnology (SCBT) CRISPR for ANKFY1
- GenScript: Design CRISPR guide RNA sequences for ANKFY1
miRNA Products
- Search ViGene Biosciences for ANKFY1
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for ANKFY1
- Browse OriGene Inhibitory RNA Products For ANKFY1
-
ViGene Biosciences ready-to-package AAV shRNAs for ANKFY1 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for ANKFY1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ANKFY1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | · | 7c | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15a | · | 15b | ^ | 16 | ^ | 17a | · | 17b | ^ | 18a | · | 18b | ^ | 19 | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||
| SP6: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: |
| ExUns: | 20a | · | 20b | ^ | 21 | ^ | 22 | ^ | 23 | ^ | 24 | ^ | 25 | ^ | 26 | ^ | 27a | · | 27b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||||||||
| SP2: | |||||||||||||||||||
| SP3: | |||||||||||||||||||
| SP4: | |||||||||||||||||||
| SP5: | - | ||||||||||||||||||
| SP6: | |||||||||||||||||||
| SP7: | |||||||||||||||||||
| SP8: |
Expression for ANKFY1 Gene
This gene is overexpressed in Stomach (7.8).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ANKFY1 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of ANKFY1 Gene:
ANKFY1SOURCE GeneReport for Unigene cluster for ANKFY1 Gene:
Hs.696087mRNA Expression by UniProt/SwissProt for ANKFY1 Gene:
Q9P2R3-ANFY1_HUMAN
Tissue specificity:
High expression in whole adult brain and intermediate expression in all other tissues and specific brain regions examined, including fetal brain.
Evidence on tissue expression from TISSUES for ANKFY1 Gene
- Nervous system(4.8)
- Liver(4.3)
- Lung(2.2)
Primer Products
-
OriGene qPCR primer pairs for ANKFY1
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ANKFY1 Gene
Orthologs for ANKFY1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ANKFY1 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | ANKFY1 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | ANKFY1 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Ankfy1 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Ankfy1 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | ANKFY1 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | ANKFY1 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | ANKFY1 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | ANKFY1 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | ankfy1 34 |
|
||
| Str.8558 34 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.9657 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | ankfy1 34 35 |
|
||
| Dr.104 34 |
|
||||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.6521 34 |
|
||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP002243 34 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | CG41099 34 35 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | F22G12.4 34 35 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
OneToOne | |
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.5217 34 |
|
- Species where no ortholog for ANKFY1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for ANKFY1 Gene
(1) SIMAP similar genes for ANKFY1 Gene using alignment to 4 proteins:
Variants for ANKFY1 Gene
| SNP ID | Clin | Chr 17 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000013345 | -- | 4,224,426(+) | ACTGC(A/G)TTAGC | intron-variant | |
| rs1000016161 | -- | 4,202,834(+) | CTATG(A/C)ATGAC | intron-variant | |
| rs1000036883 | -- | 4,265,816(+) | ATCCT(A/G)CCGCT | upstream-variant-2KB | |
| rs1000074466 | -- | 4,218,554(+) | CCAGT(G/T)TGAGC | intron-variant | |
| rs1000090878 | -- | 4,177,050(+) | CACCT(C/G)TGATG | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv1681e59 | CNV | duplication | 20981092 |
| dgv173n21 | CNV | gain | 19592680 |
| dgv3086n100 | CNV | gain | 25217958 |
| dgv557e214 | CNV | gain | 21293372 |
| esv1497662 | CNV | deletion | 17803354 |
| esv2471538 | CNV | deletion | 19546169 |
| esv25467 | CNV | loss | 19812545 |
| esv2715549 | CNV | deletion | 23290073 |
| esv2715550 | CNV | deletion | 23290073 |
| esv2751682 | CNV | gain | 17911159 |
| esv2762544 | CNV | gain | 21179565 |
| esv988491 | CNV | deletion | 20482838 |
| nsv1058176 | CNV | gain | 25217958 |
| nsv1065237 | CNV | gain | 25217958 |
| nsv1065665 | CNV | gain | 25217958 |
| nsv1951 | CNV | insertion | 18451855 |
| nsv457647 | CNV | gain | 19166990 |
| nsv574266 | CNV | gain | 21841781 |
| nsv833344 | CNV | gain | 17160897 |
| nsv978352 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
5.43% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.23;
40.09% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for ANKFY1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- ANKFY1
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANKFY1 Gene
Disorders for ANKFY1 Gene
Relevant External Links for ANKFY1
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- ANKFY1
No disorders were found for ANKFY1 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANKFY1 Gene
Publications for ANKFY1 Gene
- Characterization and chromosomal mapping of a novel human gene, ANKHZN. (PMID: 10940552) Kuriyama H. … Kuwano R. (Gene 2000) 2 3 4 64
- RhoD binds the Rab5 effector Rabankyrin-5 and has a role in trafficking of the platelet-derived growth factor receptor. (PMID: 24102721) Nehru V. … Aspenstroem P. (Traffic 2013) 3 4 64
- Rabankyrin-5 interacts with EHD1 and Vps26 to regulate endocytic trafficking and retromer function. (PMID: 22284051) Zhang J. … Caplan S. (Traffic 2012) 3 4 64
- A novel locus for autosomal recessive spastic ataxia on chromosome 17p. (PMID: 17273843) Bouslam N. … Stevanin G. (Hum. Genet. 2007) 2 3 64
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
Products for ANKFY1 Gene
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- Custom Antibody ServicesOriGene Antibodies for ANKFY1
- Browse OriGene ELISA Kits
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- OriGene Purified Proteins for ANKFY1
- Search Origene for MassSpec and Protein Over-expression Lysates for ANKFY1
- Origene Custom Protein Services for ANKFY1
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for ANKFY1
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- OriGene qPCR primer pairs for ANKFY1
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- OriGene ORF clones in human for ANKFY1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For ANKFY1
- GenScript: Next-day shipping cDNA ORF clone for ANKFY1 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for ANKFY1
- GenScript Custom Assay Services for ANKFY1
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- GenScript: Design CRISPR guide RNA sequences for ANKFY1
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- Browse Sino Biological cDNA Clones
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- Novus Biologicals Antibodies for ANKFY1
- Novus Biologicals proteins and lysates for ANKFY1
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- antibodies-online Antibodies for ANKFY1: See all 23
- antibodies-online Kits for ANKFY1: See all 11
- Search antibodies-online for proteins
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- Search GeneTex for Antibodies for ANKFY1
- Search GeneTex for Proteins for ANKFY1
- ViGene Biosciences adenoviral particle packaged cDNA for ANKFY1 gene
- ViGene Biosciences lentiviral particle packaged cDNA for ANKFY1 gene
- ViGene Biosciences ready-to-package AAV shRNAs for ANKFY1 gene
- Search ViGene Biosciences for ANKFY1
- Santa Cruz Biotechnology (SCBT) Antibodies for ANKFY1
- Search Santa Cruz Biotechnology (SCBT) for ANKFY1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for ANKFY1
- Horizon Cell Lines for ANKFY1
- Cyagen custom Knockout/knockin (KOKI) mouse models for ANKFY1
- VectorBuilder custom plasmid, inducible vectors for ANKFY1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ANKFY1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for ANKFY1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
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- (8) Gene Wiki
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- (32) CGAP SAGE
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- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
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- (59) MILLIPORE
- (60) miRBase
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- (62) NCBI
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- (64) PubMed
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- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
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- (92) Vector BioLabs
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- (100) COMPARTMENTS
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- (109) TreeFam
- (110) PathCards
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- (155) Gene ORGANizer