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ANKFY1 Gene

protein-coding   GIFtS: 49
GCID: GC17M004066

Ankyrin Repeat And FYVE Domain Containing 1

  Search for ANKFY1
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ankyrin Repeat And FYVE Domain Containing 11 2     ZFYVE142
Ankyrin Repeats Hooked To A Zinc Finger Motif2 3     Ankyrin Repeat And FYVE Domain-Containing Protein 12
ANKHZN2 3     Ankyrin Repeat Hooked To Zinc Finger Motif2
BTBD232     KIAA12553
Rabankyrin-52     

External Ids:    HGNC: 207631   Entrez Gene: 514792   Ensembl: ENSG000001857227   OMIM: 6079275   UniProtKB: Q9P2R33   

Export aliases for ANKFY1 gene to outside databases

Previous GC identifers: GC17M004410 GC17M004019 GC17M004273 GC17M004013


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ANKFY1 Gene:
This gene encodes a cytoplasmic protein that contains a coiled-coil structure and a BTB/POZ domain at its
N-terminus, ankyrin repeats in the middle portion, and a FYVE-finger motif at its C-terminus. This protein
belongs to a subgroup of double zinc finger proteins which may be involved in vesicle or protein transport.
Alternate splicing results in multiple transcript variants of this gene. (provided by RefSeq, Apr 2012)

GeneCards Summary for ANKFY1 Gene:
ANKFY1 (ankyrin repeat and FYVE domain containing 1) is a protein-coding gene. An important paralog of this gene is TNKS2.

Gene Wiki entry for ANKFY1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the ANKFY1 gene promoter:
         AhR   HOXA3   AP-1   p53   Arnt   Evi-1   E2F   E2F-1   HFH-1   Sox9   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidANKFY1 promoter sequence
   Search Chromatin IP Primers for ANKFY1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ANKFY1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.3   Ensembl cytogenetic band:  17p13.2   HGNC cytogenetic band: 17p13.3

ANKFY1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ANKFY1 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M004066:  view genomic region     (about GC identifiers)

Start:
4,066,665 bp from pter      End:
4,167,274 bp from pter
Size:
100,610 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ANFY1_HUMAN, Q9P2R3 (See protein sequence)
Recommended Name: Ankyrin repeat and FYVE domain-containing protein 1  
Size: 1169 amino acids; 128399 Da
Sequence caution: Sequence=AAH52308.1; Type=Miscellaneous discrepancy; Note=Intron retention; Sequence=BAA86569.2;
Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: A8KA65 Q5RKV4 Q9ULG5
Alternative splicing: 3 isoforms:  Q9P2R3-1   Q9P2R3-2   Q9P2R3-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ANKFY1: NX_Q9P2R3

Explore proteomics data for ANKFY1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys858, Lys1088, Lys1151
  • Modification sites at PhosphoSitePlus

  • See ANKFY1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001244928.1  NP_057460.3  

    ENSEMBL proteins: 
     ENSP00000343362   ENSP00000459943   ENSP00000459775   ENSP00000460619   ENSP00000467522  
     ENSP00000459247   ENSP00000416005  

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    Cloud-Clone Corp. Proteins for ANKFY1

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZFYVE: Zinc fingers, FYVE domain containing
    BTBD: BTB/POZ domain containing
    ANKRD: Ankyrin repeat domain containing

    Selected InterPro protein domains (see all 9):
     IPR000306 Znf_FYVE
     IPR013083 Znf_RING/FYVE/PHD
     IPR000210 BTB/POZ-like
     IPR002110 Ankyrin_rpt
     IPR011333 BTB/POZ_fold

    Graphical View of Domain Structure for InterPro Entry Q9P2R3

    ProtoNet protein and cluster: Q9P2R3

    3 Blocks protein domains:
    IPB000210 BTB/POZ domain
    IPB000306 Zn-finger
    IPB002110 Ankyrin repeat signature


    UniProtKB/Swiss-Prot: ANFY1_HUMAN, Q9P2R3
    Similarity: Contains 21 ANK repeats
    Similarity: Contains 1 BTB (POZ) domain
    Similarity: Contains 1 FYVE-type zinc finger


    Find genes that share domains with ANKFY1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with ANKFY1           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for ANKFY1:
     Increased cell death HMECs cel  Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ANKFY1
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    miRNA
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    miRTarBase miRNAs that target ANKFY1:
    hsa-mir-101-3p (MIRT027242), hsa-mir-130b-3p (MIRT020203), hsa-mir-155-5p (MIRT001572), hsa-mir-1 (MIRT023719), hsa-mir-128-3p (MIRT022005), hsa-mir-103a-3p (MIRT027089), hsa-mir-93-5p (MIRT028043), hsa-mir-760 (MIRT036757), hsa-mir-106b-5p (MIRT044335)

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    Selected qRT-PCR Assays for microRNAs that regulate ANKFY1 (see all 117):
    hsa-miR-140-5p hsa-miR-193a-3p hsa-miR-106a hsa-miR-200a hsa-miR-3921 hsa-miR-759 hsa-miR-519a hsa-miR-3916
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    Predesigned siRNA for gene silencing in human, mouse, rat ANKFY1

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    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ANKFY1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ANKFY1

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANKFY1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ANFY1_HUMAN, Q9P2R3: Cytoplasm. Endosome membrane; Peripheral membrane protein. Note=Also associated with
    endosomal membranes
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endosome5
    cytosol3

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005765lysosomal membrane IDA17897319
    GO:0010008endosome membrane ISS--
    GO:0016020membrane IDA10940552
    GO:0043231intracellular membrane-bounded organelle ----
    GO:0070062extracellular vesicular exosome IDA19056867

    Find genes that share ontologies with ANKFY1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ANKFY1
    Interactions:

        Search GeneGlobe Interaction Network for ANKFY1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    Selected Interacting proteins for ANKFY1 (Q9P2R31, 3 ENSP000003433624) via UniProtKB, MINT, STRING, and/or I2D (see all 23)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GABARAPL2P605201, 3EBI-2513908,EBI-720116 I2D: score=1 
    GBASO753233, ENSP000003130504I2D: score=3 STRING: ENSP00000313050
    ESR2Q927313, ENSP000003439254I2D: score=1 STRING: ENSP00000343925
    MAP1LC3CQ9BXW43, ENSP000003497854I2D: score=1 STRING: ENSP00000349785
    USPL1Q5W0Q73, ENSP000002553044I2D: score=2 STRING: ENSP00000255304
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150biological_process ND--

    Find genes that share ontologies with ANKFY1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ANKFY1 (ANFY1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ANKFY1 gene (3 alternative transcripts): 
    NM_001257999.1  NM_016376.3  NM_020740.2  

    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000341657(uc002fxn.3 uc002fxo.3 uc002fxp.3 uc010ckp.3 uc002fxq.1)
    ENST00000570535 ENST00000574367 ENST00000572412 ENST00000575298 ENST00000572564
    ENST00000571547 ENST00000574736 ENST00000573722 ENST00000575509 ENST00000570934
    ENST00000573250 ENST00000575955(uc010vrz.2) ENST00000433651(uc002fxr.3)

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate ANKFY1 (see all 117):
    hsa-miR-140-5p hsa-miR-193a-3p hsa-miR-106a hsa-miR-200a hsa-miR-3921 hsa-miR-759 hsa-miR-519a hsa-miR-3916
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    GenScript: all cDNA clones in your preferred vector (see all 2): ANKFY1 (NM_016376)
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      QuantiTect SYBR Green Assays in human, mouse, rat ANKFY1
      QuantiFast Probe-based Assays in human, mouse, rat ANKFY1

    Selected AceView cDNA sequences (see all 226):

    CA774507 BF380878 CB851615 BP371277 CN479607 AK025483 BQ638945 BQ438808 
    CB054536 BE550945 AA399607 AW295994 AI783513 AI630341 BI789249 AW450283 
    BU623663 BE674137 AI420179 CD172458 CB128158 AI277236 BM477612 BM974184 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ANKFY1 (see all 8)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17a · 17b ^ 18a · 18b ^ 19 ^
    SP1:                                            -                                         -           -                                               -         
    SP2:                    -     -                 -                                         -           -                                               -         
    SP3:                                            -                                                                                                               
    SP4:        -                                   -                                                                                                               
    SP5:                          -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -   

    ExUns: 20a · 20b ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27a · 27b
    SP1:                                                            
    SP2:                                                            
    SP3:                                                            
    SP4:                                                            
    SP5:  -                                                         


    ECgene alternative splicing isoforms for ANKFY1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ANKFY1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACAGACACTT
    ANKFY1 Expression
    About this image

    ANKFY1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ANKFY1 Protein Expression

    UniProtKB/Swiss-Prot: ANFY1_HUMAN, Q9P2R3
    Tissue specificity: High expression in whole adult brain and intermediate expression in all other tissues and
    specific brain regions examined, including fetal brain

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANKFY1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ANKFY1 gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ankfy11 , 5 ankyrin repeat and FYVE domain containing 11, 5 87.8(n)1
    95.04(a)1
      11 (44.47 cM)5
    117361  NM_009671.51  NP_033801.41 
     726900065 
    chicken
    (Gallus gallus)
    Aves ANKFY11 ankyrin repeat and FYVE domain containing 1 79.18(n)
    91(a)
      417494  XM_415742.4  XP_415742.4 
    lizard
    (Anolis carolinensis)
    Reptilia ANKFY16
    ankyrin repeat and FYVE domain containing 1
    86(a)
    1 ↔ 1
    GL343393.1(281682-312941)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.96572 Xenopus laevis transcribed sequence with moderate similarity more 79.33(n)    BX853285.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.1042 Transcribed sequence with weak similarity to protein more 76.82(n)    57046048 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG410991 CG41099 49.94(n)
    44.75(a)
      3355072  NM_001015359.2  NP_001015359.1 
    worm
    (Caenorhabditis elegans)
    Secernentea F22G12.41 F22G12.4 44.89(n)
    34.58(a)
      173180  NM_001265156.1  NP_001252085.1 


    ENSEMBL Gene Tree for ANKFY1 (if available)
    TreeFam Gene Tree for ANKFY1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ANKFY1 gene
    TNKS22  ANK32  ANK12  ANKRD522  TNKS2  ANKRD652  ANKRD502  INVS2  
    ANK22  ANKRD282  
    1 SIMAP similar gene for ANKFY1 using alignment to 4 protein entries:     ANFY1_HUMAN (see all proteins):
    DKFZp686M19106

    Find genes that share paralogs with ANKFY1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ANKFY1 (see all 2303)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1180153141,2
    F--4066175(+) CAGCTC/TATGAA 3 -- ds50011Minor allele frequency- T:0.02EA 120
    rs1124577451,2
    C,F--4066191(+) AAGCAG/CAACTA 3 -- ds50011Minor allele frequency- C:0.05WA 118
    rs72228601,2
    C,F,A,H--4066223(+) TGGGCA/GAACGT 3 -- ds500122Minor allele frequency- G:0.13NS EA NA WA 2646
    rs1880071781,2
    --4066238(+) AAGTTA/GATGTG 3 -- ds50010--------
    rs1815309151,2
    --4066287(+) ACAGCA/GTGGTT 3 -- ds50010--------
    rs1862602391,2
    --4066289(+) AGCGTA/GGTTAG 3 -- ds50010--------
    rs1920751631,2
    --4066329(+) ATTACG/TTGGGA 3 -- ds50010--------
    rs47905791,2
    C,F,A,H--4066404(+) ATGAGT/CTCTAT 3 -- ds500117Minor allele frequency- C:0.48NS EA NA WA 1126
    rs47905801,2
    C,F,A,H--4066519(+) GGTAGC/TGATTT 3 -- ds500124Minor allele frequency- T:0.12NA NS EA WA CSA 1602
    rs47905811,2
    C,F,A,H--4066657(+) TCCTCC/TTGAGA 3 -- ds500125Minor allele frequency- T:0.50NS EA NA WA CSA 2709

    HapMap Linkage Disequilibrium report for ANKFY1 (4066665 - 4167274 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for ANKFY1 (see all 12):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2715549CNV Deletion23290073
    esv1497662CNV Deletion17803354
    esv988491CNV Deletion20482838
    esv2471538CNV Deletion19546169
    esv2715550CNV Deletion23290073
    nsv1951CNV Insertion18451855
    esv25467CNV Loss19812545
    esv2751682CNV Gain17911159
    dgv173n21CNV Gain19592680
    nsv833344CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ANKFY1
    DNA2.0 Custom Variant and Variant Library Synthesis for ANKFY1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607927    OMIM disorders: --


    Find genes that share disorders with ANKFY1           About GenesLikeMe


    Export disorders for ANKFY1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ANKFY1 gene, integrated from 10 sources (see all 31):
    (articles sorted by number of sources associating them with ANKFY1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization and chromosomal mapping of a novel human gene, ANKHZN. (PubMed id 10940552)1, 2, 3 Kuriyama H.... Kuwano R. (Gene 2000)
    2. A novel locus for autosomal recessive spastic ataxia on chromosome 17p. (PubMed id 17273843)1, 3 Bouslam N....Stevanin G. (Hum. Genet. 2007)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (DNA Res. 2002)
    5. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10574462)1, 2 Nagase T.... Ohara O. (DNA Res. 1999)
    6. Deubiquitinase FAM/USP9X interacts with the E3 ubiquitin ligase SMURF1 protein and protects it from ligase activity-dependent self-degradation. (PubMed id 23184937)1 Xie Y....Cong F. (J. Biol. Chem. 2013)
    7. Genetic predictors of risk and resilience in psychiatric disorders: A cross-disorder genome-wide association study of functional impairment in major depressive disorder, bipolar disorder, and schizophrenia. (PubMed id 24039173)1 McGrath L.M....Smoller J.W. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2013)
    8. Targeted ubiquitination and degradation of G-protein-coupled receptor kinase 5 by the DDB1-CUL4 ubiquitin ligase complex. (PubMed id 22952844)1 Wu Z....Ma L. (PLoS ONE 2012)
    9. Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (J. Proteome Res. 2012)
    10. Rabankyrin-5 interacts with EHD1 and Vps26 to regulate endocytic trafficking and retromer function. (PubMed id 22284051)1 Zhang J....Caplan S. (Traffic 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 51479 HGNC: 20763 AceView: ANKFY1 Ensembl:ENSG00000185722 euGenes: HUgn51479
    ECgene: ANKFY1 H-InvDB: ANKFY1

    (According to HUGE)
    About This Section

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    HUGE: KIAA1255

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ANKFY1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for ANKFY1 gene:
    Search GeneIP for patents involving ANKFY1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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