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Aliases for ANKFN1 Gene

Aliases for ANKFN1 Gene

  • Ankyrin Repeat And Fibronectin Type III Domain Containing 1 2 3 5

External Ids for ANKFN1 Gene

Previous GeneCards Identifiers for ANKFN1 Gene

  • GC17P051586
  • GC17P054230
  • GC17P049590
  • GC17P056110
  • GC17P055965

Summaries for ANKFN1 Gene

GeneCards Summary for ANKFN1 Gene

ANKFN1 (Ankyrin Repeat And Fibronectin Type III Domain Containing 1) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANKFN1 Gene

Genomics for ANKFN1 Gene

Regulatory Elements for ANKFN1 Gene

Enhancers for ANKFN1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F056129 1.2 VISTA 11.7 +247.9 247911 1.7 ANKFN1 GC17M056076 GC17P056185
GH17F056171 0.8 Ensembl ENCODE 11.7 +292.1 292146 6.3 ZNF263 CTCF STAT1 SMARCA4 RAD21 EGR2 ANKFN1 GC17P056185 GC17M056076
GH17F056440 0.7 ENCODE 12 +558.4 558371 0.8 TBP STAT1 PKNOX1 JUN CEBPB KLF4 EP300 RFX5 JUND GATA3 ANKFN1 GC17P056429 GC17M056424
GH17F056320 0.4 ENCODE 10.8 +438.4 438384 1.2 MNT GABPA ANKFN1 GC17M056335 GC17P056274
GH17F056347 0.5 ENCODE 8.1 +465.8 465763 1.6 SMARCA4 POLR2A SCRT2 ANKFN1 GC17M056335 GC17P056274
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ANKFN1 on UCSC Golden Path with GeneCards custom track

Genomic Location for ANKFN1 Gene

55,882,301 bp from pter
56,511,659 bp from pter
629,359 bases
Plus strand

Genomic View for ANKFN1 Gene

Genes around ANKFN1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANKFN1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANKFN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANKFN1 Gene

Proteins for ANKFN1 Gene

  • Protein details for ANKFN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ankyrin repeat and fibronectin type-III domain-containing protein 1
    Protein Accession:

    Protein attributes for ANKFN1 Gene

    763 amino acids
    Molecular mass:
    87604 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ANKFN1 Gene

Post-translational modifications for ANKFN1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ANKFN1 Gene

Domains & Families for ANKFN1 Gene

Protein Domains for ANKFN1 Gene

Suggested Antigen Peptide Sequences for ANKFN1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 fibronectin type-III domain.
  • Contains 2 ANK repeats.
  • Contains 1 fibronectin type-III domain.
  • Contains 2 ANK repeats.
genes like me logo Genes that share domains with ANKFN1: view

Function for ANKFN1 Gene

genes like me logo Genes that share phenotypes with ANKFN1: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ANKFN1 Gene

Localization for ANKFN1 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ANKFN1 gene
Compartment Confidence
nucleus 3
cytosol 2
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ANKFN1 Gene

Pathways & Interactions for ANKFN1 Gene

SuperPathways for ANKFN1 Gene

No Data Available

Interacting Proteins for ANKFN1 Gene

Selected Interacting proteins: Q8N957-ANKF1_HUMAN for ANKFN1 Gene via IID

Gene Ontology (GO) - Biological Process for ANKFN1 Gene


No data available for Pathways by source and SIGNOR curated interactions for ANKFN1 Gene

Drugs & Compounds for ANKFN1 Gene

(1) Drugs for ANKFN1 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Hydrochlorothiazide Approved, Vet_approved Pharma Inhibition, Inhibitor 405
genes like me logo Genes that share compounds with ANKFN1: view

Transcripts for ANKFN1 Gene

Unigene Clusters for ANKFN1 Gene

Ankyrin-repeat and fibronectin type III domain containing 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ANKFN1 Gene

No ASD Table

Relevant External Links for ANKFN1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ANKFN1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ANKFN1 Gene

mRNA differential expression in normal tissues according to GTEx for ANKFN1 Gene

This gene is overexpressed in Cervix - Endocervix (x5.0) and Skin - Sun Exposed (Lower leg) (x4.4).

Protein differential expression in normal tissues from HIPED for ANKFN1 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ANKFN1 Gene

Protein tissue co-expression partners for ANKFN1 Gene

NURSA nuclear receptor signaling pathways regulating expression of ANKFN1 Gene:


SOURCE GeneReport for Unigene cluster for ANKFN1 Gene:

genes like me logo Genes that share expression patterns with ANKFN1: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for ANKFN1 Gene

Orthologs for ANKFN1 Gene

This gene was present in the common ancestor of animals.

Orthologs for ANKFN1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ANKFN1 34 35
  • 99.48 (n)
(Canis familiaris)
Mammalia ANKFN1 34 35
  • 93.36 (n)
(Bos Taurus)
Mammalia ANKFN1 34 35
  • 93.08 (n)
(Mus musculus)
Mammalia Ankfn1 34 16 35
  • 89.44 (n)
(Monodelphis domestica)
Mammalia ANKFN1 35
  • 87 (a)
(Ornithorhynchus anatinus)
Mammalia ANKFN1 35
  • 75 (a)
(Gallus gallus)
Aves ANKFN1 34 35
  • 80.03 (n)
(Anolis carolinensis)
Reptilia ANKFN1 35
  • 84 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100490095 34
  • 75.97 (n)
(Danio rerio)
Actinopterygii LOC557615 34
  • 69.61 (n)
ANKFN1 (1 of 3) 35
  • 47 (a)
AL935268.1 35
  • 39 (a)
ANKFN1 (3 of 3) 35
  • 30 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001726 34
  • 49.25 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG6954 34 35
  • 47.38 (n)
(Caenorhabditis elegans)
Secernentea R07E4.1 35
  • 16 (a)
Species where no ortholog for ANKFN1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ANKFN1 Gene

Gene Tree for ANKFN1 (if available)
Gene Tree for ANKFN1 (if available)

Paralogs for ANKFN1 Gene

No data available for Paralogs for ANKFN1 Gene

Variants for ANKFN1 Gene

Sequence variations from dbSNP and Humsavar for ANKFN1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1005207 -- 56,320,092(+) agtgg(A/G)taatc intron-variant
rs1011769 -- 56,157,572(+) ATGGC(A/G)TCTTA intron-variant
rs1014267 -- 56,445,501(+) GTAGG(A/G)ATAAC intron-variant
rs1019238 -- 56,201,354(+) TGAGC(A/G)CTCCT intron-variant
rs1019239 -- 56,201,398(+) CTGTC(A/G)TAGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ANKFN1 Gene

Variant ID Type Subtype PubMed ID
nsv960507 CNV duplication 23825009
nsv833494 CNV gain 17160897
nsv833493 CNV loss 17160897
nsv575714 CNV gain 21841781
nsv575691 CNV gain 21841781
nsv2103 CNV insertion 18451855
nsv2102 CNV insertion 18451855
nsv2100 CNV deletion 18451855
nsv1152564 CNV duplication 26484159
esv3640848 CNV loss 21293372
esv3582828 CNV loss 25503493
esv3554576 CNV deletion 23714750
esv3377290 CNV insertion 20981092
esv2716065 CNV deletion 23290073
esv2716064 CNV deletion 23290073
esv2716063 CNV deletion 23290073
esv2716061 CNV deletion 23290073
esv2716060 CNV deletion 23290073
esv2406695 CNV deletion 18987734

Variation tolerance for ANKFN1 Gene

Residual Variation Intolerance Score: 31.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.02; 80.16% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ANKFN1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANKFN1 Gene

Disorders for ANKFN1 Gene

Relevant External Links for ANKFN1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ANKFN1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANKFN1 Gene

Publications for ANKFN1 Gene

  1. A genome-wide association study of DSM-IV cannabis dependence. (PMID: 21668797) Agrawal A. … Bierut L.J. (Addict Biol 2011) 3 46 64
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  3. Identification of ten loci associated with height highlights new biological pathways in human growth. (PMID: 18391950) Lettre G. … Hirschhorn J.N. (Nat. Genet. 2008) 3 46 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. A possible mechanism behind autoimmune disorders discovered by genome-wide linkage and association analysis in celiac disease. (PMID: 23936387) A9stensson M. … Torinsson-Naluai A.8. (PLoS ONE 2013) 3 64

Products for ANKFN1 Gene

Sources for ANKFN1 Gene

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