ANKFN1 Gene
protein-coding GIFtS: 39
GCID: GC17P054230
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ankyrin-repeat and fibronectin type III domain containing...
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Aliases
for ANKFN1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
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| Ankyrin-Repeat And Fibronectin Type III Domain Containing 11 2 | | FLJ383351 | | Ankyrin Repeat And Fibronectin Type-III Domain-Containing Protein 12 |
Export aliases for ANKFN1 gene to outside databasesPrevious GC identifers: GC17P051586 GC17P049590 |
Summaries
for ANKFN1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for ANKFN1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010783.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ANKFN1 gene promoter:
AML1a CUTL1 Egr-4 Egr-2 FOXO4 FOXO1a En-1 RSRFC4 FOXO1
Other transcription factors
Search SABiosciences Chromatin IP Primers for ANKFN1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ANKFN1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q22 Ensembl cytogenetic band: 17q22 HGNC cytogenetic band: 17q23.2ANKFN1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17P054230: view genomic region
(about GC identifiers)
Start:
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54,188,319 bp from pter |
End:
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54,589,020 bp from pter |
Size:
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400,702 bases |
Orientation:
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plus strand |
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Proteins
for ANKFN1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ANKF1_HUMAN, Q8N957 (See
protein sequence)Recommended Name: Ankyrin repeat and fibronectin type-III domain-containing protein 1 Size: 763 amino acids; 87604 DaExplore the universe of human proteins at neXtProt for ANKFN1: NX_Q8N957
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8N957
ANKFN1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_694960.2
ENSEMBL proteins: ENSP00000321627 ENSP00000454224 ENSP00000458227
Human Recombinant Protein Products:
ANKFN1 Antibody Products:
Assay Products for ANKFN1: |
Protein
Domains /
Families
for ANKFN1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ANKFN1 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8N957ProtoNet protein and cluster: Q8N957 1 Blocks protein family: IPB002110 Ankyrin repeat signature
UniProtKB/Swiss-Prot: ANKF1_HUMAN, Q8N957Similarity: Contains 2 ANK repeatsSimilarity: Contains 1 fibronectin type-III domain |
Function
for ANKFN1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ANKFN1 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ANKFN1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: ANKFN1 (NM_153228) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ANKFN1 | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ANKFN1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANKFN1 |
1 GenomeRNAi human phenotype for ANKFN1:
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Pathways & Interactions
for ANKFN1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ANKFN1
|
Drugs & Compounds
for ANKFN1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ANKFN1
Search CenterWatch for drugs/clinical trials and news about ANKFN1 / ANKF1
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Transcripts
for ANKFN1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
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REFSEQ mRNAs for ANKFN1 gene: NM_153228.2 Unigene Cluster for ANKFN1: Ankyrin-repeat and fibronectin type III domain containing 1 Hs.673040 [show with all ESTs]Unigene Representative Sequence: AK0956548 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000575594 ENST00000574292 ENST00000318698(uc002iun.1) ENST00000566473
ENST00000572945 ENST00000573365 ENST00000572312 ENST00000572321
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ANKFN1 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ANKFN1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ANKFN1 (NM_153228) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ANKFN1 | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ANKFN1 |
Additional cDNA sequence: AK095654.1 BC033058.1 BC037494.1 4 DOTS entries: DT.91699478 DT.75177336 DT.100750215 DT.120902775 24/26 AceView cDNA sequences (see all 26): BG105420 BU608257 BF792011 BI771240 BF968368 BP358049 CB992473 BI047667 BI550026 NM_153228 BP356686 BM559371 AW148622 CB995602 BC037494 BC033058 AK095654 CB989453 CD110170 BF669949 CB993326 AW818321 CB995301 AW818314
GeneLoc Exon Structure
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Expression
for ANKFN1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ANKFN1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGTATATTGT
About this image
See ANKFN1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ANKFN1
SOURCE GeneReport for Unigene cluster: Hs.673040
SABiosciences Custom PCR Arrays for ANKFN1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ANKFN1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ANKFN1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ANKFN1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ANKFN1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANKFN1 |
Orthologs
for ANKFN1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of animals.
Orthologs for ANKFN1 gene from 6/15 species (see all 15) About this table
ENSEMBL Gene Tree for ANKFN1 (if available)
TreeFam Gene Tree for ANKFN1 (if available) |
Paralogs
for ANKFN1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for ANKFN1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
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| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
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HapMap Linkage Disequilibrium report for ANKFN1 (54188319 - 54438319 bp, first 250kb of ANKFN1)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ANKFN1: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ANKFN1 |
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Disorders
/ Diseases
for ANKFN1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 ANKFN1 for disorders About MalaCards
ANKFN1 for disorders About GeneDecksing
1 disease from the University of Copenhagen DISEASES database for ANKFN1:Cannabis dependence Human Genome Epidemiology (HuGE) Navigator: ANKFN1 (1 document)
Export disorders for ANKFN1 gene to outside databases
|
Publications
for ANKFN1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ANKFN1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ANKFN1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- A genome-wide association study of DSM-IV cannabis dep endence. (PubMed id 21668797)1 Agrawal A....Bierut L.J. (2011)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- Identification of ten loci associated with height highlights new biological pathways in human growth. (PubMed id 18391950)1 Lettre G....Hirschhorn J.N. (2008)
- DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PubMed id 16625196)2 Zody M.C.... Nusbaum C. (2006)
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External Searches for ANKFN1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing ANKFN1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ANKFN1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ANKFN1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ANKFN1 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for ANKFN1 gene:
Search GeneIP for patents involving ANKFN1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ANKFN1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ANKFN1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ANKFN1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ANKFN1 | | | OriGene Protein Over-expression Lysate for ANKFN1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ANKFN1 | | OriGene 3'-UTR Clone for ANKFN1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ANKFN1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ANKFN1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for ANKFN1 | | OriGene Custom Protein Services for ANKFN1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ANKFN1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ANKFN1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ANKFN1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ANKFN1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ANKFN1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ANKFN1 |
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 | | | ANKFN1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANKFN1 |
|  |  |  | | | | Search ThermoFisher Antibodies for ANKFN1 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ANKFN1 |
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