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Aliases for ANKFN1 Gene

Aliases for ANKFN1 Gene

  • Ankyrin Repeat And Fibronectin Type III Domain Containing 1 2 3 5

External Ids for ANKFN1 Gene

Previous GeneCards Identifiers for ANKFN1 Gene

  • GC17P051586
  • GC17P054230
  • GC17P049590
  • GC17P056110

Summaries for ANKFN1 Gene

GeneCards Summary for ANKFN1 Gene

ANKFN1 (Ankyrin Repeat And Fibronectin Type III Domain Containing 1) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANKFN1 Gene

Genomics for ANKFN1 Gene

Regulatory Elements for ANKFN1 Gene

Genomic Location for ANKFN1 Gene

Chromosome:
17
Start:
55,965,604 bp from pter
End:
56,511,659 bp from pter
Size:
546,056 bases
Orientation:
Plus strand

Genomic View for ANKFN1 Gene

Genes around ANKFN1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANKFN1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANKFN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANKFN1 Gene

Proteins for ANKFN1 Gene

  • Protein details for ANKFN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N957-ANKF1_HUMAN
    Recommended name:
    Ankyrin repeat and fibronectin type-III domain-containing protein 1
    Protein Accession:
    Q8N957

    Protein attributes for ANKFN1 Gene

    Size:
    763 amino acids
    Molecular mass:
    87604 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ANKFN1 Gene

Proteomics data for ANKFN1 Gene at MOPED

Post-translational modifications for ANKFN1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ANKFN1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ANKFN1 Gene

Domains & Families for ANKFN1 Gene

Protein Domains for ANKFN1 Gene

Suggested Antigen Peptide Sequences for ANKFN1 Gene

Graphical View of Domain Structure for InterPro Entry

Q8N957

UniProtKB/Swiss-Prot:

ANKF1_HUMAN :
  • Contains 1 fibronectin type-III domain.
  • Contains 2 ANK repeats.
Domain:
  • Contains 1 fibronectin type-III domain.
Similarity:
  • Contains 2 ANK repeats.
genes like me logo Genes that share domains with ANKFN1: view

Function for ANKFN1 Gene

genes like me logo Genes that share phenotypes with ANKFN1: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ANKFN1 Gene

Localization for ANKFN1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ANKFN1 Gene COMPARTMENTS Subcellular localization image for ANKFN1 gene
Compartment Confidence
nucleus 3
cytosol 2
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ANKFN1 Gene

Pathways & Interactions for ANKFN1 Gene

SuperPathways for ANKFN1 Gene

No Data Available

Interacting Proteins for ANKFN1 Gene

Gene Ontology (GO) - Biological Process for ANKFN1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ANKFN1 Gene

Drugs & Compounds for ANKFN1 Gene

(1) Drugs for ANKFN1 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Hydrochlorothiazide Approved Pharma Inhibition, Inhibitor 387
genes like me logo Genes that share compounds with ANKFN1: view

Transcripts for ANKFN1 Gene

Unigene Clusters for ANKFN1 Gene

Ankyrin-repeat and fibronectin type III domain containing 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ANKFN1 Gene

No ASD Table

Relevant External Links for ANKFN1 Gene

GeneLoc Exon Structure for
ANKFN1
ECgene alternative splicing isoforms for
ANKFN1

Expression for ANKFN1 Gene

mRNA expression in normal human tissues for ANKFN1 Gene

mRNA differential expression in normal tissues according to GTEx for ANKFN1 Gene

This gene is overexpressed in Cervix - Endocervix (x5.0) and Skin - Sun Exposed (Lower leg) (x4.4).

Protein differential expression in normal tissues from HIPED for ANKFN1 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ANKFN1 Gene



SOURCE GeneReport for Unigene cluster for ANKFN1 Gene Hs.673040

genes like me logo Genes that share expression patterns with ANKFN1: view

Protein tissue co-expression partners for ANKFN1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for ANKFN1 Gene

Orthologs for ANKFN1 Gene

This gene was present in the common ancestor of animals.

Orthologs for ANKFN1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ANKFN1 36
  • 99 (a)
OneToOne
ANKFN1 35
  • 99.48 (n)
  • 99.21 (a)
cow
(Bos Taurus)
Mammalia ANKFN1 35
  • 93.08 (n)
  • 95.55 (a)
ANKFN1 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ANKFN1 36
  • 95 (a)
OneToOne
ANKFN1 35
  • 93.36 (n)
  • 95.02 (a)
mouse
(Mus musculus)
Mammalia Ankfn1 36
  • 94 (a)
OneToOne
Ankfn1 35
  • 89.44 (n)
  • 94.88 (a)
oppossum
(Monodelphis domestica)
Mammalia ANKFN1 36
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ANKFN1 36
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves ANKFN1 35
  • 80.03 (n)
  • 84.52 (a)
ANKFN1 36
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ANKFN1 36
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100490095 35
  • 75.97 (n)
  • 79.8 (a)
zebrafish
(Danio rerio)
Actinopterygii AL935268.1 36
  • 39 (a)
OneToMany
ANKFN1 (1 of 3) 36
  • 47 (a)
OneToMany
ANKFN1 (3 of 3) 36
  • 30 (a)
OneToMany
LOC557615 35
  • 69.61 (n)
  • 71.55 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001726 35
  • 49.25 (n)
  • 38.56 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG6954 35
  • 47.38 (n)
  • 36.36 (a)
CG6954 36
  • 15 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea R07E4.1 36
  • 16 (a)
OneToOne
Species with no ortholog for ANKFN1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ANKFN1 Gene

ENSEMBL:
Gene Tree for ANKFN1 (if available)
TreeFam:
Gene Tree for ANKFN1 (if available)

Paralogs for ANKFN1 Gene

No data available for Paralogs for ANKFN1 Gene

Variants for ANKFN1 Gene

Sequence variations from dbSNP and Humsavar for ANKFN1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs10852985 - 56,457,273(+) TAGCC(A/G)TTATA reference, missense
rs874988 -- 56,291,961(+) TATGA(A/C)AAATT intron-variant
rs919599 -- 56,103,582(-) AAATC(A/G)CTTTT intron-variant
rs929585 -- 56,372,315(-) GTACA(C/T)ATTTG intron-variant
rs891653 -- 56,011,719(+) CATAA(C/T)TTGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ANKFN1 Gene

Variant ID Type Subtype PubMed ID
nsv908620 CNV Loss 21882294
nsv2100 CNV Loss 18451855
nsv833493 CNV Loss 17160897
nsv2102 CNV Insertion 18451855
esv2716060 CNV Deletion 23290073
esv2716061 CNV Deletion 23290073
esv2406695 CNV Deletion 18987734
esv2716063 CNV Deletion 23290073
esv2716064 CNV Deletion 23290073
esv2716065 CNV Deletion 23290073
nsv2103 CNV Insertion 18451855
nsv833494 CNV Gain 17160897

Variation tolerance for ANKFN1 Gene

Residual Variation Intolerance Score: 31.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.02; 80.16% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ANKFN1 Gene

HapMap Linkage Disequilibrium report
ANKFN1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANKFN1 Gene

Disorders for ANKFN1 Gene

Relevant External Links for ANKFN1

Genetic Association Database (GAD)
ANKFN1
Human Genome Epidemiology (HuGE) Navigator
ANKFN1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ANKFN1

No disorders were found for ANKFN1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANKFN1 Gene

Publications for ANKFN1 Gene

  1. A genome-wide association study of DSM-IV cannabis dependence. (PMID: 21668797) Agrawal A. … Bierut L.J. (Addict Biol 2011) 3 48 67
  2. A possible mechanism behind autoimmune disorders discovered by genome-wide linkage and association analysis in celiac disease. (PMID: 23936387) A9stensson M. … Torinsson-Naluai A.8. (PLoS ONE 2013) 3
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3
  4. Identification of ten loci associated with height highlights new biological pathways in human growth. (PMID: 18391950) Lettre G. … Hirschhorn J.N. (Nat. Genet. 2008) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for ANKFN1 Gene

Sources for ANKFN1 Gene

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