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Aliases for ANKFN1 Gene

Aliases for ANKFN1 Gene

  • Ankyrin-Repeat And Fibronectin Type III Domain Containing 1 2 3

External Ids for ANKFN1 Gene

Summaries for ANKFN1 Gene

GeneCards Summary for ANKFN1 Gene

ANKFN1 (Ankyrin-Repeat And Fibronectin Type III Domain Containing 1) is a Protein Coding gene. Diseases associated with ANKFN1 include cannabis dependence.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANKFN1 Gene

Genomics for ANKFN1 Gene

Genomic Location for ANKFN1 Gene

Start:
56,110,958 bp from pter
End:
56,511,659 bp from pter
Size:
400,702 bases
Orientation:
Plus strand

Genomic View for ANKFN1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ANKFN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANKFN1 Gene

Regulatory Elements for ANKFN1 Gene

Proteins for ANKFN1 Gene

  • Protein details for ANKFN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N957-ANKF1_HUMAN
    Recommended name:
    Ankyrin repeat and fibronectin type-III domain-containing protein 1
    Protein Accession:
    Q8N957
    Secondary Accessions:

    Protein attributes for ANKFN1 Gene

    Size:
    763 amino acids
    Molecular mass:
    87604 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ANKFN1 Gene

Proteomics data for ANKFN1 Gene at MOPED

Post-translational modifications for ANKFN1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ANKFN1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ANKFN1 Gene

Domains for ANKFN1 Gene

Gene Families for ANKFN1 Gene

HGNC:
  • ANKRD :Ankyrin repeat domain containing
  • FN3 :Fibronectin type III domain containing

Protein Domains for ANKFN1 Gene

UniProtKB/Swiss-Prot:

ANKF1_HUMAN
Domain:
  • Contains 1 fibronectin type-III domain.:
    • Q8N957
Similarity:
  • Contains 2 ANK repeats.:
    • Q8N957
genes like me logo Genes that share domains with ANKFN1: view

Function for ANKFN1 Gene

Gene Ontology (GO) - Molecular Function for ANKFN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with ANKFN1: view

Phenotypes for ANKFN1 Gene

GenomeRNAi human phenotypes for ANKFN1:
genes like me logo Genes that share phenotypes with ANKFN1: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ANKFN1 Gene

Localization for ANKFN1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ANKFN1 Gene COMPARTMENTS Subcellular localization image for ANKFN1 gene
Compartment Confidence
cytosol 2
nucleus 2
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for ANKFN1 Gene

Pathways for ANKFN1 Gene

SuperPathways for ANKFN1 Gene

No Data Available

Interacting Proteins for ANKFN1 Gene

Gene Ontology (GO) - Biological Process for ANKFN1 Gene

None

No data available for Pathways by source for ANKFN1 Gene

Transcripts for ANKFN1 Gene

Unigene Clusters for ANKFN1 Gene

Ankyrin-repeat and fibronectin type III domain containing 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ANKFN1 Gene

No ASD Table

Relevant External Links for ANKFN1 Gene

GeneLoc Exon Structure for
ANKFN1
ECgene alternative splicing isoforms for
ANKFN1

Expression for ANKFN1 Gene

mRNA expression in normal human tissues for ANKFN1 Gene

mRNA differential expression in normal tissues according to GTEx for ANKFN1 Gene

This gene is overexpressed in Cervix - Endocervix (5.0) and Skin - Sun Exposed (Lower leg) (4.4).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for ANKFN1 Gene

SOURCE GeneReport for Unigene cluster for ANKFN1 Gene Hs.673040

genes like me logo Genes that share expressions with ANKFN1: view

Orthologs for ANKFN1 Gene

This gene was present in the common ancestor of animals.

Orthologs for ANKFN1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ANKFN1 36
  • 99.48 (n)
  • 99.21 (a)
ANKFN1 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ANKFN1 36
  • 93.08 (n)
  • 95.55 (a)
ANKFN1 37
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ANKFN1 36
  • 93.36 (n)
  • 95.02 (a)
ANKFN1 37
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ankfn1 36
  • 89.44 (n)
  • 94.88 (a)
Ankfn1 16
Ankfn1 37
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ANKFN1 37
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ANKFN1 37
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves ANKFN1 36
  • 80.03 (n)
  • 84.52 (a)
ANKFN1 37
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ANKFN1 37
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100490095 36
  • 75.97 (n)
  • 79.8 (a)
zebrafish
(Danio rerio)
Actinopterygii AL935268.1 37
  • 39 (a)
OneToMany
ANKFN1 (1 of 3) 37
  • 47 (a)
OneToMany
ANKFN1 (3 of 3) 37
  • 30 (a)
OneToMany
LOC557615 36
  • 69.61 (n)
  • 71.55 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001726 36
  • 49.25 (n)
  • 38.56 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG6954 36
  • 47.38 (n)
  • 36.36 (a)
CG6954 37
  • 15 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea R07E4.1 37
  • 16 (a)
OneToOne
Species with no ortholog for ANKFN1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ANKFN1 Gene

ENSEMBL:
Gene Tree for ANKFN1 (if available)
TreeFam:
Gene Tree for ANKFN1 (if available)

Paralogs for ANKFN1 Gene

No data available for Paralogs for ANKFN1 Gene

Variants for ANKFN1 Gene

Sequence variations from dbSNP and Humsavar for ANKFN1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs729642 -- 56,156,316(+) CTCCT(A/G)GCCTC intron-variant
rs731445 -- 56,228,296(+) TATTA(C/T)TCTTT intron-variant
rs733391 -- 56,450,801(-) ATTCT(C/G)ATGAG intron-variant
rs741126 -- 56,228,189(+) TAAAG(C/G)TAGAT intron-variant
rs741128 -- 56,181,752(+) cttat(A/G)tataG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ANKFN1 Gene

Variant ID Type Subtype PubMed ID
nsv908620 CNV Loss 21882294
nsv2100 CNV Loss 18451855
nsv833493 CNV Loss 17160897
nsv2102 CNV Insertion 18451855
esv2716060 CNV Deletion 23290073
esv2716061 CNV Deletion 23290073
esv2406695 CNV Deletion 18987734
esv2716063 CNV Deletion 23290073
esv2716064 CNV Deletion 23290073
esv2716065 CNV Deletion 23290073
nsv2103 CNV Insertion 18451855
nsv833494 CNV Gain 17160897

Relevant External Links for ANKFN1 Gene

HapMap Linkage Disequilibrium report
ANKFN1

Disorders for ANKFN1 Gene

(1) MalaCards Diseases for ANKFN1 Gene

Search for ANKFN1 Gene in MalaCards »

(1) University of Copenhagen DISEASES for ANKFN1 Gene

Relevant External Links for ANKFN1

Genetic Association Database (GAD)
ANKFN1
Human Genome Epidemiology (HuGE) Navigator
ANKFN1
genes like me logo Genes that share disorders with ANKFN1: view

No data available for UniProtKB/Swiss-Prot for ANKFN1 Gene

Publications for ANKFN1 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. Identification of ten loci associated with height highlights new biological pathways in human growth. (PMID: 18391950) Lettre G. … Hirschhorn J.N. (Nat. Genet. 2008) 3 49
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49
  4. A genome-wide association study of DSM-IV cannabis dependence. (PMID: 21668797) Agrawal A. … Bierut L.J. (Addict Biol 2011) 3 49
  5. A possible mechanism behind autoimmune disorders discovered by genome-wide linkage and association analysis in celiac disease. (PMID: 23936387) A9stensson M. … Torinsson-Naluai A.8. (PLoS ONE 2013) 3

Products for ANKFN1 Gene

Sources for ANKFN1 Gene

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