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Aliases for ANKDD1B Gene

Aliases for ANKDD1B Gene

  • Ankyrin Repeat And Death Domain Containing 1B 2 3 5

External Ids for ANKDD1B Gene

Previous GeneCards Identifiers for ANKDD1B Gene

  • GC00U921788
  • GC05U900758
  • GC05P074935
  • GC05P070112
  • GC05P074907

Summaries for ANKDD1B Gene

GeneCards Summary for ANKDD1B Gene

ANKDD1B (Ankyrin Repeat And Death Domain Containing 1B) is a Protein Coding gene. An important paralog of this gene is ANKDD1A.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANKDD1B Gene

Genomics for ANKDD1B Gene

Regulatory Elements for ANKDD1B Gene

Enhancers for ANKDD1B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05F075668 1.2 Ensembl ENCODE 13.1 +58.1 58083 1.8 ATF1 ARNT WRNIP1 ARID4B DMAP1 YY1 FOS JUNB REST TBX21 POC5 ANKDD1B RNU6-680P
GH05F075677 1.1 FANTOM5 Ensembl ENCODE 11.7 +66.9 66863 1.6 ETS2 HLF ZMYM3 NR2F2 RARA POC5 ANKDD1B POLK COL4A3BP ANKRD31 RNU6-680P
GH05F075335 1.2 ENCODE 9.3 -272.3 -272279 7.8 CREB3L1 MLX FEZF1 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC TBX21 RPS26P26 RAP1BL NSA2 ANKDD1B GCNT4 POLK POC5 GC05P075337 ENSG00000271815
GH05F075660 0.9 Ensembl ENCODE 10.8 +49.4 49398 1.2 ZNF687 HLF JUNB GATA3 EED IKZF1 ETV6 PRDM1 SPI1 POC5 ANKDD1B RNU6-680P
GH05F075656 0.9 Ensembl ENCODE 10.3 +45.5 45478 1.0 ZNF263 PKNOX1 SP2 FEZF1 RARA ZNF366 POLR2A ZNF341 PRDM10 ZNF600 ANKDD1B RNU6-680P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ANKDD1B on UCSC Golden Path with GeneCards custom track

Promoters for ANKDD1B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001283135 582 1600 KLF17 ARID4B FEZF1 ZNF48 CHAMP1 SCRT2 KLF7 FOS MIXL1 EGR2

Genomic Location for ANKDD1B Gene

Chromosome:
5
Start:
75,611,218 bp from pter
End:
75,671,846 bp from pter
Size:
60,629 bases
Orientation:
Plus strand

Genomic View for ANKDD1B Gene

Genes around ANKDD1B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANKDD1B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANKDD1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANKDD1B Gene

Proteins for ANKDD1B Gene

  • Protein details for ANKDD1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NHY2-AKD1B_HUMAN
    Recommended name:
    Ankyrin repeat and death domain-containing protein 1B
    Protein Accession:
    A6NHY2

    Protein attributes for ANKDD1B Gene

    Size:
    528 amino acids
    Molecular mass:
    59088 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ANKDD1B Gene

Post-translational modifications for ANKDD1B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ANKDD1B Gene

No data available for DME Specific Peptides for ANKDD1B Gene

Domains & Families for ANKDD1B Gene

Gene Families for ANKDD1B Gene

Protein Domains for ANKDD1B Gene

Suggested Antigen Peptide Sequences for ANKDD1B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A6NHY2

UniProtKB/Swiss-Prot:

AKD1B_HUMAN :
  • Contains 1 death domain.
  • Contains 10 ANK repeats.
Domain:
  • Contains 1 death domain.
Similarity:
  • Contains 10 ANK repeats.
genes like me logo Genes that share domains with ANKDD1B: view

Function for ANKDD1B Gene

Phenotypes for ANKDD1B Gene

GenomeRNAi human phenotypes for ANKDD1B:
genes like me logo Genes that share phenotypes with ANKDD1B: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ANKDD1B Gene

Localization for ANKDD1B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ANKDD1B gene
Compartment Confidence
mitochondrion 2
nucleus 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ANKDD1B Gene

Pathways & Interactions for ANKDD1B Gene

SuperPathways for ANKDD1B Gene

No Data Available

Gene Ontology (GO) - Biological Process for ANKDD1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
genes like me logo Genes that share ontologies with ANKDD1B: view

No data available for Pathways by source and SIGNOR curated interactions for ANKDD1B Gene

Transcripts for ANKDD1B Gene

mRNA/cDNA for ANKDD1B Gene

(8) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ANKDD1B Gene

Ankyrin repeat and death domain containing 1B:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ANKDD1B Gene

No ASD Table

Relevant External Links for ANKDD1B Gene

GeneLoc Exon Structure for
ANKDD1B
ECgene alternative splicing isoforms for
ANKDD1B

Expression for ANKDD1B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ANKDD1B Gene

mRNA differential expression in normal tissues according to GTEx for ANKDD1B Gene

This gene is overexpressed in Colon - Transverse (x6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ANKDD1B Gene



NURSA nuclear receptor signaling pathways regulating expression of ANKDD1B Gene:

ANKDD1B

SOURCE GeneReport for Unigene cluster for ANKDD1B Gene:

Hs.370455
genes like me logo Genes that share expression patterns with ANKDD1B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for ANKDD1B Gene

Orthologs for ANKDD1B Gene

This gene was present in the common ancestor of animals.

Orthologs for ANKDD1B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ANKDD1B 34 35
  • 99.61 (n)
dog
(Canis familiaris)
Mammalia ANKDD1B 35
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ankdd1b 34 16 35
  • 82.67 (n)
cow
(Bos Taurus)
Mammalia ANKDD1B 34 35
  • 79.89 (n)
oppossum
(Monodelphis domestica)
Mammalia ANKDD1B 35
  • 62 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 8 (a)
ManyToMany
chicken
(Gallus gallus)
Aves ANKDD1B 34 35
  • 68.15 (n)
lizard
(Anolis carolinensis)
Reptilia ANKDD1B 35
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ankdd1b 34
  • 53.84 (n)
zebrafish
(Danio rerio)
Actinopterygii ankdd1b 34 35
  • 54.43 (n)
worm
(Caenorhabditis elegans)
Secernentea mib-1 35
  • 14 (a)
ManyToMany
ikb-1 35
  • 11 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 35 (a)
OneToMany
Species where no ortholog for ANKDD1B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ANKDD1B Gene

ENSEMBL:
Gene Tree for ANKDD1B (if available)
TreeFam:
Gene Tree for ANKDD1B (if available)

Paralogs for ANKDD1B Gene

Paralogs for ANKDD1B Gene

(12) SIMAP similar genes for ANKDD1B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ANKDD1B: view

Variants for ANKDD1B Gene

Sequence variations from dbSNP and Humsavar for ANKDD1B Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs10035878 -- 75,666,689(+) GTCTC(A/G)GTTAC intron-variant, nc-transcript-variant
rs1004201 -- 75,615,018(-) ACACT(A/G)AGTAA intron-variant
rs10051731 -- 75,653,767(+) TTCTC(C/T)GTTGA intron-variant
rs10060260 -- 75,627,756(+) GATTG(C/T)TTCCA intron-variant
rs10067641 -- 75,627,153(+) CCACC(A/G)TGCAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ANKDD1B Gene

Variant ID Type Subtype PubMed ID
nsv1140549 CNV deletion 24896259
nsv1150512 CNV duplication 26484159
nsv478221 CNV novel sequence insertion 20440878
nsv518475 CNV gain 19592680
nsv522003 CNV loss 19592680
nsv830353 CNV gain 17160897

Variation tolerance for ANKDD1B Gene

Gene Damage Index Score: 14.92; 96.78% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ANKDD1B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ANKDD1B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANKDD1B Gene

Disorders for ANKDD1B Gene

Relevant External Links for ANKDD1B

Genetic Association Database (GAD)
ANKDD1B
Human Genome Epidemiology (HuGE) Navigator
ANKDD1B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ANKDD1B

No disorders were found for ANKDD1B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANKDD1B Gene

Publications for ANKDD1B Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  2. The DNA sequence and comparative analysis of human chromosome 5. (PMID: 15372022) Schmutz J. … Rubin E.M. (Nature 2004) 3 4 64

Products for ANKDD1B Gene

Sources for ANKDD1B Gene

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