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Aliases for ANKDD1A Gene

Aliases for ANKDD1A Gene

  • Ankyrin Repeat And Death Domain Containing 1A 2 3 5

External Ids for ANKDD1A Gene

Previous GeneCards Identifiers for ANKDD1A Gene

  • GC15P062995
  • GC15P065204
  • GC15P042029
  • GC15P064958
  • GC15P065428

Summaries for ANKDD1A Gene

GeneCards Summary for ANKDD1A Gene

ANKDD1A (Ankyrin Repeat And Death Domain Containing 1A) is a Protein Coding gene. An important paralog of this gene is ANKDD1B.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANKDD1A Gene

Genomics for ANKDD1A Gene

Regulatory Elements for ANKDD1A Gene

Enhancers for ANKDD1A Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ANKDD1A on UCSC Golden Path with GeneCards custom track

Promoters for ANKDD1A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ANKDD1A on UCSC Golden Path with GeneCards custom track

Genomic Location for ANKDD1A Gene

Chromosome:
15
Start:
64,911,902 bp from pter
End:
64,958,700 bp from pter
Size:
46,799 bases
Orientation:
Plus strand

Genomic View for ANKDD1A Gene

Genes around ANKDD1A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANKDD1A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANKDD1A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANKDD1A Gene

Proteins for ANKDD1A Gene

  • Protein details for ANKDD1A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q495B1-AKD1A_HUMAN
    Recommended name:
    Ankyrin repeat and death domain-containing protein 1A
    Protein Accession:
    Q495B1
    Secondary Accessions:
    • Q495B2
    • Q495B3
    • Q8N7A0
    • Q8NBS5

    Protein attributes for ANKDD1A Gene

    Size:
    522 amino acids
    Molecular mass:
    57550 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC05399.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305}; Sequence=BAC11532.1; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305};

    Alternative splice isoforms for ANKDD1A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ANKDD1A Gene

Proteomics data for ANKDD1A Gene at MOPED

Post-translational modifications for ANKDD1A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ANKDD1A Gene

No data available for DME Specific Peptides for ANKDD1A Gene

Domains & Families for ANKDD1A Gene

Gene Families for ANKDD1A Gene

Protein Domains for ANKDD1A Gene

Graphical View of Domain Structure for InterPro Entry

Q495B1

UniProtKB/Swiss-Prot:

AKD1A_HUMAN :
  • Contains 1 death domain.
  • Contains 11 ANK repeats.
Domain:
  • Contains 1 death domain.
Similarity:
  • Contains 11 ANK repeats.
genes like me logo Genes that share domains with ANKDD1A: view

Function for ANKDD1A Gene

genes like me logo Genes that share phenotypes with ANKDD1A: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ANKDD1A Gene

Localization for ANKDD1A Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ANKDD1A Gene COMPARTMENTS Subcellular localization image for ANKDD1A gene
Compartment Confidence
cytosol 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ANKDD1A Gene

Pathways & Interactions for ANKDD1A Gene

SuperPathways for ANKDD1A Gene

No Data Available

Interacting Proteins for ANKDD1A Gene

Gene Ontology (GO) - Biological Process for ANKDD1A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ANKDD1A Gene

Drugs & Compounds for ANKDD1A Gene

No Compound Related Data Available

Transcripts for ANKDD1A Gene

Unigene Clusters for ANKDD1A Gene

Ankyrin repeat and death domain containing 1A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ANKDD1A Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b
SP1: - - - -
SP2: - - - - - -
SP3:
SP4: - - - -
SP5: - -
SP6: - - - -
SP7:
SP8: - -

Relevant External Links for ANKDD1A Gene

GeneLoc Exon Structure for
ANKDD1A
ECgene alternative splicing isoforms for
ANKDD1A

Expression for ANKDD1A Gene

mRNA expression in normal human tissues for ANKDD1A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ANKDD1A Gene

This gene is overexpressed in Heart (67.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ANKDD1A Gene



SOURCE GeneReport for Unigene cluster for ANKDD1A Gene Hs.207157

genes like me logo Genes that share expression patterns with ANKDD1A: view

Protein tissue co-expression partners for ANKDD1A Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ANKDD1A Gene

Orthologs for ANKDD1A Gene

This gene was present in the common ancestor of animals.

Orthologs for ANKDD1A Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia ANKDD1A 35
  • 86.49 (n)
  • 85.46 (a)
ANKDD1A 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia A730067D02Rik 35
  • 84.44 (n)
  • 85.12 (a)
Ankdd1a 16
Ankdd1a 36
  • 82 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ANKDD1A 35
  • 99.36 (n)
  • 99.04 (a)
ANKDD1A 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ankdd1a 35
  • 83.2 (n)
  • 83.06 (a)
cow
(Bos Taurus)
Mammalia ANKDD1A 36
  • 60 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ANKDD1A 36
  • 67 (a)
OneToOne
chicken
(Gallus gallus)
Aves ANKDD1A 35
  • 67.08 (n)
  • 64.88 (a)
ANKDD1A 36
  • 63 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ANKDD1A 36
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ankdd1a 35
  • 63.7 (n)
  • 60.32 (a)
zebrafish
(Danio rerio)
Actinopterygii ankdd1a 35
  • 63.04 (n)
  • 59.06 (a)
ankdd1a 36
  • 57 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8740 35
worm
(Caenorhabditis elegans)
Secernentea ikb-1 36
  • 15 (a)
ManyToMany
mib-1 36
  • 15 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 42 (a)
OneToMany
Species with no ortholog for ANKDD1A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ANKDD1A Gene

ENSEMBL:
Gene Tree for ANKDD1A (if available)
TreeFam:
Gene Tree for ANKDD1A (if available)

Paralogs for ANKDD1A Gene

Paralogs for ANKDD1A Gene

Pseudogenes.org Pseudogenes for ANKDD1A Gene

genes like me logo Genes that share paralogs with ANKDD1A: view

Variants for ANKDD1A Gene

Sequence variations from dbSNP and Humsavar for ANKDD1A Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs34988193 - 64,943,580(+) GAGAT(A/G)AGGTA reference, missense
rs5813333 -- 64,927,622(+) TTTTT(-/T)GAGAC intron-variant
rs5813334 -- 64,940,395(+) TGATT(-/GATA)GATAG intron-variant
rs6494503 -- 64,949,598(+) GGCTG(A/G)GGAGG intron-variant
rs11857130 -- 64,925,828(+) ACTCC(A/G)GAGCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ANKDD1A Gene

Variant ID Type Subtype PubMed ID
dgv31n68 CNV Loss 17160897
nsv833041 CNV Loss 17160897
esv2659431 CNV Deletion 23128226

Variation tolerance for ANKDD1A Gene

Residual Variation Intolerance Score: 91% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.28; 90.62% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ANKDD1A Gene

Disorders for ANKDD1A Gene

Relevant External Links for ANKDD1A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ANKDD1A

No disorders were found for ANKDD1A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANKDD1A Gene

Publications for ANKDD1A Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta G.D. … Pelletier L. (Cell 2015) 3
  4. New gene functions in megakaryopoiesis and platelet formation. (PMID: 22139419) Gieger C. … Soranzo N. (Nature 2011) 3

Products for ANKDD1A Gene

Sources for ANKDD1A Gene

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