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Aliases for ANKAR Gene

Aliases for ANKAR Gene

  • Ankyrin And Armadillo Repeat Containing 2 3
  • FLJ25415 6

External Ids for ANKAR Gene

Summaries for ANKAR Gene

GeneCards Summary for ANKAR Gene

ANKAR (Ankyrin And Armadillo Repeat Containing) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANKAR Gene

Genomics for ANKAR Gene

Genomic Location for ANKAR Gene

Start:
189,674,290 bp from pter
End:
189,761,193 bp from pter
Size:
86,904 bases
Orientation:
Plus strand

Genomic View for ANKAR Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ANKAR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANKAR Gene

Regulatory Elements for ANKAR Gene

Proteins for ANKAR Gene

  • Protein details for ANKAR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z5J8-ANKAR_HUMAN
    Recommended name:
    Ankyrin and armadillo repeat-containing protein
    Protein Accession:
    Q7Z5J8
    Secondary Accessions:
    • Q3ZCS6
    • Q4G0M2
    • Q6ZU02

    Protein attributes for ANKAR Gene

    Size:
    1434 amino acids
    Molecular mass:
    162026 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ANKAR Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ANKAR Gene

Proteomics data for ANKAR Gene at MOPED

Post-translational modifications for ANKAR Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ANKAR Gene

No data available for DME Specific Peptides for ANKAR Gene

Domains for ANKAR Gene

Gene Families for ANKAR Gene

HGNC:
  • ARMC :Armadillo repeat containing
  • ANKRD :Ankyrin repeat domain containing

Suggested Antigen Peptide Sequences for ANKAR Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7Z5J8

UniProtKB/Swiss-Prot:

ANKAR_HUMAN
Similarity:
  • Contains 5 ANK repeats.:
    • Q7Z5J8
  • Contains 6 ARM repeats.:
    • Q7Z5J8
genes like me logo Genes that share domains with ANKAR: view

Function for ANKAR Gene

Gene Ontology (GO) - Molecular Function for ANKAR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003713 transcription coactivator activity IBA --
GO:0005488 binding --
GO:0005515 protein binding --
GO:0035257 nuclear hormone receptor binding IBA --
genes like me logo Genes that share ontologies with ANKAR: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ANKAR Gene

Localization for ANKAR Gene

Subcellular locations from UniProtKB/Swiss-Prot for ANKAR Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ANKAR Gene COMPARTMENTS Subcellular localization image for ANKAR gene
Compartment Confidence
plasma membrane 3
cytoskeleton 1
cytosol 1
endoplasmic reticulum 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for ANKAR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005737 cytoplasm IBA --
GO:0005913 cell-cell adherens junction IBA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ANKAR: view

Pathways for ANKAR Gene

SuperPathways for ANKAR Gene

No Data Available

Interacting Proteins for ANKAR Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000313513%0d%0a9606.ENSP00000311505%0d%0a
Selected Interacting proteins: ENSP00000313513 for ANKAR Gene via STRING

Symbol External ID(s) Details
IQCB1

Gene Ontology (GO) - Biological Process for ANKAR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042659 regulation of cell fate specification IBA --
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IBA --
genes like me logo Genes that share ontologies with ANKAR: view

No data available for Pathways by source for ANKAR Gene

Transcripts for ANKAR Gene

Unigene Clusters for ANKAR Gene

Ankyrin and armadillo repeat containing:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ANKAR Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b · 14c ^ 15a · 15b ^ 16 ^ 17 ^
SP1: - - -
SP2: - - - -
SP3: - - - - - - - -
SP4: - - - - - - - - - - -
SP5: - - - - - - - -
SP6:
SP7:

ExUns: 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24a · 24b
SP1:
SP2: - -
SP3: -
SP4: - -
SP5:
SP6:
SP7:

Relevant External Links for ANKAR Gene

GeneLoc Exon Structure for
ANKAR
ECgene alternative splicing isoforms for
ANKAR

Expression for ANKAR Gene

mRNA expression in normal human tissues for ANKAR Gene

mRNA differential expression in normal tissues according to GTEx for ANKAR Gene

This gene is overexpressed in Testis (4.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ANKAR Gene

SOURCE GeneReport for Unigene cluster for ANKAR Gene Hs.655700

mRNA Expression by UniProt/SwissProt for ANKAR Gene

Q7Z5J8-ANKAR_HUMAN
Tissue specificity: Ubiquitously expressed with highest level in pancreas and lowest in skeletal muscle.
genes like me logo Genes that share expressions with ANKAR: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for ANKAR Gene

Orthologs for ANKAR Gene

This gene was present in the common ancestor of chordates.

Orthologs for ANKAR Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ANKAR 35
  • 99.49 (n)
  • 99.65 (a)
ANKAR 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ANKAR 35
  • 90.16 (n)
  • 88.9 (a)
ANKAR 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ANKAR 35
  • 84.9 (n)
  • 86.24 (a)
ANKAR 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ankar 35
  • 83.22 (n)
  • 81.68 (a)
Ankar 16
Ankar 36
  • 80 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ANKAR 36
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ANKAR 36
  • 65 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ankar 35
  • 84.72 (n)
  • 85.93 (a)
lizard
(Anolis carolinensis)
Reptilia ANKAR 36
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ankar 35
  • 62.88 (n)
  • 55.8 (a)
zebrafish
(Danio rerio)
Actinopterygii ankar 35
  • 56.5 (n)
  • 49.3 (a)
ankar 36
  • 48 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 35 (a)
OneToOne
Species with no ortholog for ANKAR:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ANKAR Gene

ENSEMBL:
Gene Tree for ANKAR (if available)
TreeFam:
Gene Tree for ANKAR (if available)

Paralogs for ANKAR Gene

Pseudogenes.org Pseudogenes for ANKAR Gene

genes like me logo Genes that share paralogs with ANKAR: view

No data available for Paralogs for ANKAR Gene

Variants for ANKAR Gene

Sequence variations from dbSNP and Humsavar for ANKAR Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs920427 -- 189,689,231(-) GACAC(A/T)ATAAC intron-variant
rs1020151 -- 189,672,729(+) ACTTA(C/T)ATAAT upstream-variant-2KB
rs1225079 -- 189,722,918(+) GAAAT(A/C)AATTA intron-variant
rs1225080 -- 189,722,966(+) ATTAT(C/G)TCCTC intron-variant
rs1225081 -- 189,723,049(+) AACTT(C/T)AGTGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ANKAR Gene

Variant ID Type Subtype PubMed ID
esv2721260 CNV Deletion 23290073
esv2721261 CNV Deletion 23290073

Relevant External Links for ANKAR Gene

HapMap Linkage Disequilibrium report
ANKAR

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANKAR Gene

Disorders for ANKAR Gene

(1) University of Copenhagen DISEASES for ANKAR Gene

genes like me logo Genes that share disorders with ANKAR: view

No data available for UniProtKB/Swiss-Prot for ANKAR Gene

Publications for ANKAR Gene

  1. Characterization of a novel human gene containing ANK repeats and ARM domains. (PMID: 15110750) Occhi G. … Danieli G.A. (Biochem. Biophys. Res. Commun. 2004) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  4. Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways. (PMID: 21565611) Sang L. … Jackson P.K. (Cell 2011) 3
  5. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie A.G. … Butte N.F. (PLoS ONE 2012) 3

Products for ANKAR Gene

Sources for ANKAR Gene

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