ANKAR Gene
protein-coding GIFtS: 43
GCID: GC02P190539
|
|
ankyrin and armadillo repeat containing
| |
Aliases
for ANKAR gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Ankyrin And Armadillo Repeat Containing1 2 | | FLJ254151 5 | | Ankyrin And Armadillo Repeat-Containing Protein2 |
Export aliases for ANKAR gene to outside databasesPrevious GC identifers: GC02P190249 GC02P182400 |
Summaries
for ANKAR gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for ANKAR gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_005403.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ANKAR gene promoter:
C/EBPbeta Brachyury MEF-2 HSF1 (long) MEF-2A COMP1 Cart-1 HSF1short aMEF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for ANKAR
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ANKAR |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2q32.2 Ensembl cytogenetic band: 2q32.2 HGNC cytogenetic band: 2q32.2ANKAR Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02P190539: view genomic region
(about GC identifiers)
Start:
|
190,539,016 bp from pter |
End:
|
190,625,919 bp from pter |
Size:
|
86,904 bases |
Orientation:
|
plus strand |
|
Proteins
for ANKAR gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ANKAR_HUMAN, Q7Z5J8 (See
protein sequence)Recommended Name: Ankyrin and armadillo repeat-containing protein Size: 1434 amino acids; 162026 Da
Subcellular location: Membrane; Single-pass membrane protein (Potential)
Secondary accessions: Q3ZCS6 Q4G0M2 Q6ZU02Alternative splicing: 4 isoforms: Q7Z5J8-1 Q7Z5J8-2 Q7Z5J8-3 Q7Z5J8-4 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for ANKAR: NX_Q7Z5J8
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q7Z5J8
ANKAR Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_653309.3
ENSEMBL proteins: ENSP00000407459 ENSP00000427882 ENSP00000399928 ENSP00000313513 ENSP00000397243 ENSP00000393043 ENSP00000281412
Human Recombinant Protein Products for ANKAR:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
IEA | -- |
ANKAR for ontologies About GeneDecksing
ANKAR Antibody Products:
Assay Products for ANKAR: |
Protein
Domains /
Families
for ANKAR gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ANKAR for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q7Z5J8ProtoNet protein and cluster: Q7Z5J8 2 Blocks protein families: IPB000225 Armadillo repeat IPB002110 Ankyrin repeat signature
UniProtKB/Swiss-Prot: ANKAR_HUMAN, Q7Z5J8Similarity: Contains 5 ANK repeatsSimilarity: Contains 6 ARM repeats |
Function
for ANKAR gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ANKAR (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ANKAR
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: ANKAR (NM_144708) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ANKAR | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ANKAR |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANKAR |
|
Pathways & Interactions
for ANKAR gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ANKAR
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for ANKAR (ENSP000003135134) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for ANKAR gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ANKAR
Search CenterWatch for drugs/clinical trials and news about ANKAR
|
Transcripts
for ANKAR gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ANKAR gene: NM_144708.3 Unigene Cluster for ANKAR: Ankyrin and armadillo repeat containing Hs.655700 [show with all ESTs]Unigene Representative Sequence: NM_14470812 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000441800 ENST00000461516 ENST00000520309(uc002uqw.2) ENST00000433782(uc002uqv.1)
ENST00000467927 ENST00000464687 ENST00000474303 ENST00000476208 ENST00000313581
ENST00000438402(uc002uqx.2) ENST00000431575(uc002uqu.3 uc002uqy.2)
ENST00000281412
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ANKAR (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ANKAR
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ANKAR (NM_144708) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ANKAR | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ANKAR |
Additional cDNA sequence: AJ549812.1 AJ605761.1 AK098551.1 AK307328.1 BC037215.1 13 DOTS entries: DT.91868675 DT.95155013 DT.101982066 DT.102831973 DT.406766 DT.97827929 DT.102831974 DT.100747392 DT.40230882 DT.406765 DT.75191939 DT.92001424 DT.95155014 24/46 AceView cDNA sequences (see all 46): BU742505 AJ549812 AK058144 BP369815 AI004397 BC037215 BC044907 AK098551 AI420597 AK027836 BU607916 BI768753 BX481346 AJ605761 BX451643 AK126073 AA770340 BX461934 AI126423 BX404781 F09623 BM728465 AA634472 BX503559
GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for ANKAR (see all 7) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14a | · | 14b | · | 14c | ^ | 15a | · | 15b | ^ | 16 | ^ | 17 | ^ |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | - | | - | | | | | | | | | | - | | |
| SP3: | | | | | | | - | | - | | - | | - | | | | | | - | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | - | | - | | |
| SP4: | | | | | | | - | | - | | - | | - | | | | - | | - | | - | | | | | | | | | | | | | | | | | | - | | - | | | | | | | | - | | - | | |
| SP5: | | | | | | | - | | - | | - | | - | | | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 18 | ^ | 19 | ^ | 20 | ^ | 21 | ^ | 22 | ^ | 23 | ^ | 24a | · | 24b |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | |
| SP2: | - | | | | | | | | - | | | | | | | | |
| SP3: | - | | | | | | | | | | | | | | | | |
| SP4: | - | | | | | | | | - | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for ANKAR
|
Expression
for ANKAR gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ANKAR expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGACTCTTCA
About this image
See ANKAR Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ANKAR
SOURCE GeneReport for Unigene cluster: Hs.655700
UniProtKB/Swiss-Prot: ANKAR_HUMAN, Q7Z5J8Tissue specificity: Ubiquitously expressed with highest level in pancreas and lowest in skeletal muscle
SABiosciences Custom PCR Arrays for ANKAR
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ANKAR
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ANKAR | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ANKAR | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ANKAR | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANKAR |
Orthologs
for ANKAR gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for ANKAR gene from 4/17 species (see all 17) About this table
ENSEMBL Gene Tree for ANKAR (if available)
TreeFam Gene Tree for ANKAR (if available) |
Paralogs
for ANKAR gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ANKAR gene
ANKAR for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for ANKAR
PGOHUM00000233119
|
Genomic Variants
for ANKAR gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ANKAR (190539016 - 190625919 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ANKAR: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ANKAR |
|
Disorders
/ Diseases
for ANKAR gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ANKAR for disorders About GeneDecksing
OMIM gene information: 609803
OMIM disorders: --
2  diseases for ANKAR: About MalaCardsloeys-dietz syndrome ehlers-danlos syndrome
1 disease from the University of Copenhagen DISEASES database for ANKAR:Loeys-Dietz syndrome Export disorders for ANKAR gene to outside databases
|
Publications
for ANKAR gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ANKAR gene integrated from 9 sources:
(articles sorted by number of sources associating them with ANKAR) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Characterization of a novel human gene containing ANK repeats and ARM domains. (PubMed id 15110750)1, 2, 3 Occhi G.... Danieli G.A. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W....Wilson R.K. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for ANKAR gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ANKAR gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ANKAR gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ANKAR gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ANKAR | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ANKAR gene:
Search GeneIP for patents involving ANKAR
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ANKAR gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ANKAR | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ANKAR | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ANKAR | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ANKAR | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ANKAR | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ANKAR | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for ANKAR | | OriGene Custom Protein Services for ANKAR | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ANKAR | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ANKAR | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ANKAR | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ANKAR | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ANKAR | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ANKAR |
| |
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| | | | Search Tocris compounds for ANKAR |
| |  |  |  |  | | | | |
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 | | | ANKAR Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANKAR |
|  |  |  |  | | | | Search ThermoFisher Antibodies for ANKAR |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ANKAR |
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