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Aliases for ANKAR Gene

Aliases for ANKAR Gene

  • Ankyrin And Armadillo Repeat Containing 2 3 5

External Ids for ANKAR Gene

Previous GeneCards Identifiers for ANKAR Gene

  • GC02P190249
  • GC02P190539
  • GC02P182400

Summaries for ANKAR Gene

GeneCards Summary for ANKAR Gene

ANKAR (Ankyrin And Armadillo Repeat Containing) is a Protein Coding gene. GO annotations related to this gene include binding and nuclear hormone receptor binding.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANKAR Gene

Genomics for ANKAR Gene

Regulatory Elements for ANKAR Gene

Enhancers for ANKAR Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ANKAR on UCSC Golden Path with GeneCards custom track

Promoters for ANKAR Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ANKAR on UCSC Golden Path with GeneCards custom track

Genomic Location for ANKAR Gene

Chromosome:
2
Start:
189,674,290 bp from pter
End:
189,763,058 bp from pter
Size:
88,769 bases
Orientation:
Plus strand

Genomic View for ANKAR Gene

Genes around ANKAR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANKAR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANKAR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANKAR Gene

Proteins for ANKAR Gene

  • Protein details for ANKAR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z5J8-ANKAR_HUMAN
    Recommended name:
    Ankyrin and armadillo repeat-containing protein
    Protein Accession:
    Q7Z5J8
    Secondary Accessions:
    • Q3ZCS6
    • Q4G0M2
    • Q6ZU02

    Protein attributes for ANKAR Gene

    Size:
    1434 amino acids
    Molecular mass:
    162026 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ANKAR Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ANKAR Gene

Proteomics data for ANKAR Gene at MOPED

Post-translational modifications for ANKAR Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ANKAR Gene

No data available for DME Specific Peptides for ANKAR Gene

Domains & Families for ANKAR Gene

Suggested Antigen Peptide Sequences for ANKAR Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7Z5J8

UniProtKB/Swiss-Prot:

ANKAR_HUMAN :
  • Contains 5 ANK repeats.
Similarity:
  • Contains 5 ANK repeats.
  • Contains 6 ARM repeats.
genes like me logo Genes that share domains with ANKAR: view

Function for ANKAR Gene

Phenotypes for ANKAR Gene

GenomeRNAi human phenotypes for ANKAR:
genes like me logo Genes that share phenotypes with ANKAR: view

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ANKAR Gene

Localization for ANKAR Gene

Subcellular locations from UniProtKB/Swiss-Prot for ANKAR Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ANKAR Gene COMPARTMENTS Subcellular localization image for ANKAR gene
Compartment Confidence
plasma membrane 3
cytoskeleton 2
cytosol 1
endoplasmic reticulum 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for ANKAR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with ANKAR: view

Pathways & Interactions for ANKAR Gene

SuperPathways for ANKAR Gene

No Data Available

Interacting Proteins for ANKAR Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000313513%0d%0a9606.ENSP00000311505%0d%0a
Selected Interacting proteins: ENSP00000313513 for ANKAR Gene via STRING

Symbol External ID(s) Details
IQCB1

Gene Ontology (GO) - Biological Process for ANKAR Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ANKAR Gene

Drugs & Compounds for ANKAR Gene

No Compound Related Data Available

Transcripts for ANKAR Gene

Unigene Clusters for ANKAR Gene

Ankyrin and armadillo repeat containing:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ANKAR Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b · 14c ^ 15a · 15b ^ 16 ^ 17 ^
SP1: - - -
SP2: - - - -
SP3: - - - - - - - -
SP4: - - - - - - - - - - -
SP5: - - - - - - - -
SP6:
SP7:

ExUns: 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24a · 24b
SP1:
SP2: - -
SP3: -
SP4: - -
SP5:
SP6:
SP7:

Relevant External Links for ANKAR Gene

GeneLoc Exon Structure for
ANKAR
ECgene alternative splicing isoforms for
ANKAR

Expression for ANKAR Gene

mRNA expression in normal human tissues for ANKAR Gene

mRNA differential expression in normal tissues according to GTEx for ANKAR Gene

This gene is overexpressed in Testis (x4.6).

Protein differential expression in normal tissues from HIPED for ANKAR Gene

This gene is overexpressed in Pancreatic juice (44.5) and Heart (24.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ANKAR Gene



SOURCE GeneReport for Unigene cluster for ANKAR Gene Hs.655700

mRNA Expression by UniProt/SwissProt for ANKAR Gene

Q7Z5J8-ANKAR_HUMAN
Tissue specificity: Ubiquitously expressed with highest level in pancreas and lowest in skeletal muscle.
genes like me logo Genes that share expression patterns with ANKAR: view

Protein tissue co-expression partners for ANKAR Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for ANKAR Gene

Orthologs for ANKAR Gene

This gene was present in the common ancestor of chordates.

Orthologs for ANKAR Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ANKAR 35
  • 90.16 (n)
  • 88.9 (a)
ANKAR 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ANKAR 35
  • 84.9 (n)
  • 86.24 (a)
ANKAR 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ankar 35
  • 83.22 (n)
  • 81.68 (a)
Ankar 16
Ankar 36
  • 80 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ANKAR 35
  • 99.49 (n)
  • 99.65 (a)
ANKAR 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ankar 35
  • 84.72 (n)
  • 85.93 (a)
oppossum
(Monodelphis domestica)
Mammalia ANKAR 36
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ANKAR 36
  • 65 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ANKAR 36
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ankar 35
  • 62.88 (n)
  • 55.8 (a)
zebrafish
(Danio rerio)
Actinopterygii ankar 35
  • 56.5 (n)
  • 49.3 (a)
ankar 36
  • 48 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 35 (a)
OneToOne
Species with no ortholog for ANKAR:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ANKAR Gene

ENSEMBL:
Gene Tree for ANKAR (if available)
TreeFam:
Gene Tree for ANKAR (if available)

Paralogs for ANKAR Gene

Pseudogenes.org Pseudogenes for ANKAR Gene

genes like me logo Genes that share paralogs with ANKAR: view

No data available for Paralogs for ANKAR Gene

Variants for ANKAR Gene

Sequence variations from dbSNP and Humsavar for ANKAR Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs16831887 - 189,707,050(+) ATAAT(A/G)TAATC nc-transcript-variant, reference, missense
rs1225090 - 189,730,532(+) CAATT(G/T)GTTGT intron-variant, nc-transcript-variant, reference, missense
rs1550388 -- 189,739,054(-) CAAAA(A/G)GAAAC intron-variant, downstream-variant-500B
rs920427 -- 189,689,231(-) GACAC(A/T)ATAAC intron-variant
rs1899027 -- 189,718,608(+) TCAGA(C/T)AGCTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ANKAR Gene

Variant ID Type Subtype PubMed ID
esv2721260 CNV Deletion 23290073
esv2721261 CNV Deletion 23290073

Variation tolerance for ANKAR Gene

Residual Variation Intolerance Score: 89.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.32; 76.66% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ANKAR Gene

HapMap Linkage Disequilibrium report
ANKAR

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANKAR Gene

Disorders for ANKAR Gene

Relevant External Links for ANKAR

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ANKAR

No disorders were found for ANKAR Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANKAR Gene

Publications for ANKAR Gene

  1. Characterization of a novel human gene containing ANK repeats and ARM domains. (PMID: 15110750) Occhi G. … Danieli G.A. (Biochem. Biophys. Res. Commun. 2004) 2 3 4 67
  2. Genome-wide association study identifies variants in PMS1 associated with serum ferritin in a Chinese population. (PMID: 25162662) Liao M. … Zhang H. (PLoS ONE 2014) 3
  3. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie A.G. … Butte N.F. (PLoS ONE 2012) 3
  4. Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways. (PMID: 21565611) Sang L. … Jackson P.K. (Cell 2011) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for ANKAR Gene

Sources for ANKAR Gene

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