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ANK3 Gene

protein-coding GIFtS: 57

GC10M061458

ankyrin 3, node of Ranvier (ankyrin G)
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
ANK-3 ^³
ANKYRIN-G ^²
Ankyrin-G ^³
FLJ45464 ^²

Descriptions
ankyrin 3 ^²
ankyrin 3, node of Ranvier (ankyrin G) ^²
ankyrin G119 ^²
ankyrin-3, node of Ranvier ^²

External Ids
HGNC: 494¹
Entrez Gene: 288²
UniProtKB: Q12955³
Ensembl: ENSG00000151150⁷

Search outside databases for aliases for ANK3 gene

Previous GC identifers: GC10M060584 GC10M060813 GC10M061680 GC10M061132

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for ANK3:

Ankyrins are a family of proteins that are believed to link the integral membrane proteins to the

underlying spectrin-actin cytoskeleton and play key roles in activities such as cell motility,

activation, proliferation, contact, and the maintenance of specialized membrane domains. Multiple

isoforms of ankyrin with different affinities for various target proteins are expressed in a

tissue-specific, developmentally regulated manner. Most ankyrins are typically composed of three

structural domains: an amino-terminal domain containing multiple ankyrin repeats; a central region

with a highly conserved spectrin binding domain; and a carboxy-terminal regulatory domain which is

the least conserved and subject to variation. Ankyrin 3 is an immunologically distinct gene

product from ankyrins 1 and 2, and was originally found at the axonal initial segment and nodes of

Ranvier of neurons in the central and peripheral nervous systems. Alternatively spliced variants

may be expressed in other tissues. Although multiple transcript variants encoding several

different isoforms have been found for this gene, the full-length nature of only two have been

characterized. [provided by RefSeq]

UniProtKB/Swiss-Prot: ANK3_HUMAN, Q12955

Function: Membrane-cytoskeleton linker. The neural-specific isoforms may participate in the

maintenance/targeting of ion channels and cell adhesion molecules at the nodes of Ranvier and

axonal initial segments

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the ANK3 gene

Entrez Gene cytogenetic band: 10q21 Ensembl cytogenetic band: 10q21.2 HGNC cytogenetic band: 10q21

ANK3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 10 GeneLoc Exon Structure

GeneLoc location for GC10M061458: (about GC identifiers)

Start:	61,458,165 bp from pter
End:	61,819,494 bp from pter
Size:	361,330 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000010.9 NT_008583.16

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: ANK3_HUMAN, Q12955 (See protein sequence)

Recommended Name: Ankyrin-3

Size: 4372 amino acids; 479853 Da

Subunit: Neural-specific isoforms may be a constituent of a neurofascin/NRCAM/ankyrin G complex.

Interacts with RHBG

Subcellular location: Cytoplasm, cytoskeleton

Secondary accessions: Q5VXD5

Alternative splicing: 2 isoforms: Q12955-1 Q12955-2 (A number of isoforms are produced)

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_001140.2 NP_066267.2

ENSEMBL proteins:

ENSP00000378715 ENSP00000378713 ENSP00000362933 ENSP00000280772 ENSP00000347436 ENSP00000362921

ENSP00000362923 ENSP00000362926 ENSP00000378707 ENSP00000378711

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Ankyrin G)
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005575	cellular_component	ND	--
GO:0005737	cytoplasm	IEA	--
GO:0005856	cytoskeleton	IEA	--

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Antibodies for ANK3:

	Invitrogen Antibodies for ANK3
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (Ankyrin G), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for ANK3

Assays for ANK3:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q12955

ProtoNet protein and cluster: Q12955

3 Blocks protein families:

IPB000488 Death domain

IPB000906 ZU5 domain

IPB002110 Ankyrin repeat signature

UniProtKB/Swiss-Prot: ANK3_HUMAN, Q12955

Similarity: Contains 23 ANK repeats

Similarity: Contains 1 death domain

Similarity: Contains 1 ZU5 domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ANK3)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_020987

Applied Biosystems Silencer® siRNAs for ANK3

Sigma-Aldrich siRNA and siRNA Panels for ANK3

Sigma-Aldrich shRNA Panels and shRNA for ANK3

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001149
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001149
untagged cDNA clones in CMV expression vector (see all 2): NM_001149

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_020987

UniProtKB/Swiss-Prot: ANK3_HUMAN, Q12955

Function: Membrane-cytoskeleton linker. The neural-specific isoforms may participate in the

maintenance/targeting of ion channels and cell adhesion molecules at the nodes of Ranvier and

axonal initial segments

Genatlas biochemistry entry for ANK3:

ankyrin 3,non erythrocytic,intermediate filament associated protein (IFAP,type III),expressed in

the axonal initial segment and Ranvier nodes in the central and peripheral nervous system

3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Ank3):

behavior/neurological

life span-post-weaning/aging

nervous system

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003674	molecular_function	ND	--
GO:0005515	protein binding	IPI	15611082

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Gene Network Central^TM Interacting Genes and Proteins Network for ANK3

5/16 Interacting proteins for ANK3 (ENSP00000280772³) via UniProtKB, MINT, and/or STRING (see all 16 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SPTBN4	ENSP00000263373³	STRING (score=.97)
L1CAM	ENSP00000359075³	STRING (score=.965)
SCN2A	ENSP00000283256³	STRING (score=.949)
NFASC	ENSP00000356140³	STRING (score=.933)
COL17A1	ENSP00000340937³	STRING (score=.876)

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2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006605	protein targeting	NAS	7836469
GO:0007165	signal transduction	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for ANK3
2 Novoseek chemical compound relationships for ANK3 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
sodium	53.31	22	11950515 (5), 19064667 (3), 15797713 (3), 17548513 (2) (see all 11)
inositol 1,4,5 trisphosphate	26.34	1	17074766 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ANK3)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_020987

Sigma-Aldrich siRNA and siRNA Panels for ANK3

Sigma-Aldrich shRNA Panels and shRNA for ANK3

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001149 NM_020987

REFSEQ mRNAs for ANK3 gene (2 alternative transcripts):

NM_001149.2 NM_020987.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001149 NM_020987

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001149
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001149
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_001149

Additional cDNA sequence:

AB209308.1 AK092361.1 AK092527.1 AK124230.1 AK126851.1 AK128763.1 AK128784.1 AK292927.1

AK295661.1 AL136710.1 BX537917.1 BX648574.1 EF139850.1 U13616.1

24/32 DOTS entries (see all 32 ):

DT.118237 DT.91946173 DT.92474267 DT.95308106 DT.95201870 DT.100679148 DT.121283958 DT.40302436

DT.95190384 DT.121284083 DT.100740021 DT.91864328 DT.70100610 DT.86850267 DT.97823089 DT.97862772

DT.100788278 DT.40207447 DT.97782497 DT.449043 DT.95157943 DT.100814663 DT.121283897 DT.121284018

24/285 AceView cDNA sequences (see all 285 ):

CB853599 BX486657 BF436099 AA677185 AA866119 AA995085 AI084306 AA460992

AI131275 H87682 BX108319 AI050977 AI339255 AI740514 AA838714 AA788785

BE328825 BM689667 W39432 CD676253 BM718793 BQ022190 Z38220 CF529946

highest scoring ESTs for ANK3:

U13616 BX537917 BX648574 AA001682 AA021643 AA027295 AA027296 AA037355 AA318318 AA350542

Unigene Cluster for ANK3:

Ankyrin 3, node of Ranvier (ankyrin G)

Hs.499725 [show with all ESTs]

Unigene Representative Sequence: NM_020987

GeneLoc Exon Structure

5/13 Alternative Splicing Database (ASD) splice patterns (SP) for ANK3 (see all 13 )

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11	^	12	^	13	^	14	^	15a	·	15b	^	16	^	17	^	18a	·	18b	^	19	^	20	^	21	^	22a	·	22b	^	23	^
SP1:																																			-		-		-		-		-				-
SP2:																																					-		-		-		-
SP3:																																									-		-
SP4:
SP5:

ExUns:	24a	·	24b	^	25	^	26	^	27a	·	27b	^	28	^	29	^	30	^	31a	·	31b	^	32	^	33	^	34a	·	34b	^	35	^	36a	·	36b	^	37	^	38a	·	38b	·	38c	^	39	^	40a	·	40b	·	40c	^
SP1:					-																				-
SP2:					-																				-				-										-
SP3:					-
SP4:																													-										-
SP5:

ExUns:	41	^	42a	·	42b
SP1:
SP2:
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for ANK3

10 Ensembl transcripts including schematic representations:

ENST00000395304 ENST00000395302 ENST00000373827 ENST00000280772 ENST00000355288 ENST00000373815

ENST00000373817 ENST00000373820 ENST00000395293 ENST00000395299

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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ANK3 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ANK3

¹ / ² / ³

10 probe-sets matching ANK3 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
36967_g_at²^{, 3}	U95-A	1	1.00	1.00	0.85	0.61	U43965	0.40	1.00	0.76	1
36965_at²^{, 3}	U95-A	1	1.00	1.00	0.75	1.54	U13616	1.00	1.00	1.00	1
71824_at²^{, 3}	U95-D	1	0.75	1.00	0.63	0.90	H95543	0.60	1.00	0.82	1
36966_at*²^{, 3}	U95-A	2	1.00	0.91	0.51	0.42	U43965	0.40	1.00	0.76	1
207950_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_001149	0.60	1.00	0.82	1
206385_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_020987	0.60	1.00	0.82	1
209442_x_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AL136710	0.60	1.00	0.82	1
207950_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
206385_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
209442_x_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks ANK3 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TGTATCACCT

SOURCE GeneReport for Unigene cluster: Hs.499725
Expression variation in blood from EXPOLDB for ANK3
UniProtKB/Swiss-Prot: ANK3_HUMAN, Q12955
Tissue specificity: Expressed in brain and other tissues. Isoform 1 is neural-specific

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ANK3 gene from 5/11 species (see all 11 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	ANK3¹	--	ankyrin 3, node of Ranvier (ankyrin G)	92.5(n) 94.61(a)	479215 XM_536358.2 XP_536358.2
rat (Rattus norvegicus)	Ank3¹	--	ankyrin 3, epithelial	81.02(n) 86.92(a)	361833 NM_001033984.1 NP_001029156.1
mouse (Mus musculus)	Ank3^{1, 5}	10 (38.00 cM)⁵	ankyrin 3, epithelial^{1, 5}	85.84(n)¹ 94.47(a)¹	11735¹ NM_146005.3¹ NP_666117.2¹ AB057357⁵ AF130364⁵ (see all 32)
chicken (Gallus gallus)	ANK3¹	--	ankyrin 3	80.39(n) 83.18(a)	396309 XM_421546.2 XP_421546.2
zebrafish (Danio rerio)	LOC794638¹	--	similar to ankyrin 3	64.01(n) 63.99(a)	794638 XM_001921195.1 XP_001921230.1

About this table Species with no ortholog for ANK3

ENSEMBL Gene Tree for ANK3

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for ANK3 gene

ANK1² ANK2²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/2224 NCBI SNPs in ANK3 are shown (see all 2224 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 817)

AB	SNP ID	Valid	Chr 10 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs2288359^1,2	A,C,F,H,O	61572029(+)	`TTCTCC/TTGATG`	2	--	int¹ ng3¹		16	EA NA EU WA	2430
	rs2248570^1,2	A,C,F,H	61571799(+)	`GTCTGC/TATTTC`	2	--	ng3¹ int¹		5	EA EU WA	1912
	rs10994219^1,2	A,C,F,H	61572095(+)	`GCCGTC/TGCACC`	2	--	int¹ ng3¹		8	EU EA WA	838
	rs1551683^1,2	A,C,F,H	61820365(-)	`CTTCCG/AGTGTG`	1	--	ng3¹		8	EU EA WA	838
	rs1049862^1,2	A,C,F,H	61459278(-)	`AATTCC/TTGCCA`	2	--	ut3¹ ese³		4	MN EA WA	474
	rs10821687^1,2	A,C,F,H	61572206(+)	`ATATTC/TTTCCT`	2	--	ng3¹ int¹		12	EU EA WA NA	1056
	rs6479694^1,2	A,C,F,H	61570362(+)	`CCCCCC/AAAAAA`	2	--	ut5¹ int¹		7	NA EU EA WA	552
	rs16914794^1,2	C,F,H	61570788(+)	`GAACAC/GTGGGA`	2	--	ng3¹ int¹		7	NA EU EA WA	544
	rs16914968^1,2	C,F,H	61819549(+)	`GCCATC/TGTAAT`	1	--	ng3¹		15	NA EU EA WA	1394
	rs12261793^1,2	C,F,H	61485718(+)	`AGTGAT/CTTCTG`	2	V/I	mis¹		8	EU EA WA	840

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HapMap Linkage Disequilibrium images for ANK3 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 600465

2 Novoseek disease relationships for ANK3 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
neuroma	60.02	20	12507143 (8), 11950515 (3), 15519868 (2)
brugada syndrome	52.60	2	16650839 (1), 15579534 (1)

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Human Genome Epidemiology Navigator: ANK3 (5 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/64 PubMed articles for ANK3 gene (see all 64 ):

The ammonium transporter RhBG: requirement of a tyrosine-based signal and ankyrin-G for basolateral targeting and membrane anchorage in polarized kidney epithelial cells. (PubMed id 15611082)^{3, 4} Lopez C.... Colin Y. (2005)
Chromosomal localization of the ankyrinG gene (ANK3/Ank3) to human 10q21 and mouse 10. (PubMed id 7665168)^{2, 3} Kapfhamer D....Burmeister M. (1995)
AnkyrinG. A new ankyrin gene with neural-specific isoforms localized at the axonal initial segment and node of Ranvier. (PubMed id 7836469)^{3, 4} Kordeli E.... Bennett V. (1995)
Painful neuromas: a potential role for a structural transmembrane protein, ankyrin G. (PubMed id 12507143)^{1, 3} Kretschmer T....Kline D.G. (2002)
The smaller isoforms of ankyrin 3 bind to the p85 subunit of phosphatidylinositol 3'-kinase and enhance platelet-derived growth factor receptor down-regulation. (PubMed id 16377635)^{1, 3} Ignatiuk A....Anderson D.H. (2006)
Lateral membrane biogenesis in human bronchial epithelial cells requires 190-kDa ankyrin-G. (PubMed id 14757759)^{1, 3} Kizhatil K. and Bennett V. (2004)
Ankyrin-G regulates inactivation gating of the neuronal sodium channel, Nav1.6. (PubMed id 16775201)^{1, 3} Shirahata E....Hayasaka K. (2006)
Ankyrin-G and beta2-spectrin collaborate in biogenesis of lateral membrane of human bronchial epithelial cells. (PubMed id 17074766)^{1, 3} Kizhatil K....Bennett V. (2007)
Ankyrin G and voltage gated sodium channels colocalize in human neuroma--key proteins of membrane remodeling after axonal injury. (PubMed id 11950515)^{1, 3} Kretschmer T....Kline D.G. (2002)
Phosphorylation and ankyrin-G binding of the C-terminal domain regulate targeting and function of the ammonium transporter RhBG. (PubMed id 18635543)^{1, 3} Sohet F....Lopez C. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 288	HGNC: 494	AceView: ANK3	Ensembl:ENSG00000151150	euGenes: HUgn288
ECgene: ANK3	H-InvDB: ANK3

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
Wikipedia	http://en.wikipedia.org/wiki/Ankyrin

Licensable Technologies for ANK3
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for ANK3:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ANK3-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for ANK3		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for ANK3		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
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	Recombinant Proteins (Ankyrin G)
	Antibodies (Ankyrin G)

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GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
ANK3 Gene at Home site.
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ANK3 Gene

protein-coding GIFtS: 57

Aliases &
Descriptions
for ANK3

Summaries
for ANK3

Genomic Location
for ANK3

Proteins
for ANK3

Protein Domains/
Families
for ANK3

Gene Function
for ANK3

Pathways & Interactions
for ANK3

Drugs & Compounds
for ANK3

Transcripts
for ANK3

Expression
for ANK3

Orthologs
for ANK3

Paralogs
for ANK3

SNPs/Variants
for ANK3

Disorders & Mutations
for ANK3

Medical News
for ANK3

Publications
for ANK3

Search for ANK3

Genome Databases showing ANK3

Other Databases showing ANK3

Specialized Databases showing ANK3

Licensable Technologies
for ANK3

Services
for ANK3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ANK3 Gene

protein-coding GIFtS: 57

Aliases & Descriptionsfor ANK3

Summariesfor ANK3

Genomic Locationfor ANK3

Proteinsfor ANK3

Protein Domains/Familiesfor ANK3

Gene Functionfor ANK3

Pathways & Interactionsfor ANK3

Drugs & Compoundsfor ANK3

Transcriptsfor ANK3

Expression for ANK3

Orthologsfor ANK3

Paralogsfor ANK3

SNPs/Variantsfor ANK3

Disorders & Mutationsfor ANK3

Medical Newsfor ANK3

Publicationsfor ANK3

Search for ANK3

Genome Databases showing ANK3

Other Databases showing ANK3

Specialized Databases showing ANK3

Licensable Technologiesfor ANK3

Servicesfor ANK3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ANK3

Summaries
for ANK3

Genomic Location
for ANK3

Proteins
for ANK3

Protein Domains/
Families
for ANK3

Gene Function
for ANK3

Pathways & Interactions
for ANK3

Drugs & Compounds
for ANK3

Transcripts
for ANK3

Expression
for ANK3

Orthologs
for ANK3

Paralogs
for ANK3

SNPs/Variants
for ANK3

Disorders & Mutations
for ANK3

Medical News
for ANK3

Publications
for ANK3

Licensable Technologies
for ANK3

Services
for ANK3