Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



ANK1 Gene

protein-coding   GIFtS: 66
GCID: GC08M041510

Ankyrin 1, Erythrocytic


(Previous symbol: ANK)
  See ANK1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Ankyrin 1, Erythrocytic1 2     SPH12
ANK1 2 3     ankyrin-12
Erythrocyte Ankyrin2 3     ankyrin-R2
ANK-12 3     Ankyrin-R3
SPH22 5     

External Ids:    HGNC: 4921   Entrez Gene: 2862   Ensembl: ENSG000000295347   OMIM: 6126415   UniProtKB: P161573   

Export aliases for ANK1 gene to outside databases

Previous GC identifers: GC08M042256 GC08M041539 GC08M041251 GC08M041528 GC08M041629 GC08M040038


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for ANK1 Gene:
Ankyrins are a family of proteins that link the integral membrane proteins to the underlying spectrin-actin
cytoskeleton and play key roles in activities such as cell motility, activation, proliferation, contact and the
maintenance of specialized membrane domains. Multiple isoforms of ankyrin with different affinities for various
target proteins are expressed in a tissue-specific, developmentally regulated manner. Most ankyrins are typically
composed of three structural domains: an amino-terminal domain containing multiple ankyrin repeats; a central
region with a highly conserved spectrin binding domain; and a carboxy-terminal regulatory domain which is the
least conserved and subject to variation. Ankyrin 1, the prototype of this family, was first discovered in the
erythrocytes, but since has also been found in brain and muscles. Mutations in erythrocytic ankyrin 1 have been
associated in approximately half of all patients with hereditary spherocytosis. Complex patterns of alternative
splicing in the regulatory domain, giving rise to different isoforms of ankyrin 1 have been described. Truncated
muscle-specific isoforms of ankyrin 1 resulting from usage of an alternate promoter have also been identified.
(provided by RefSeq, Dec 2008)

GeneCards Summary for ANK1 Gene:
ANK1 (ankyrin 1, erythrocytic) is a protein-coding gene. Diseases associated with ANK1 include 8p11.2 deletion syndrome, and hereditary spherocytosis. GO annotations related to this gene include enzyme binding and structural constituent of cytoskeleton. An important paralog of this gene is TNKS2.

UniProtKB/Swiss-Prot: ANK1_HUMAN, P16157
Function: Attaches integral membrane proteins to cytoskeletal elements; binds to the erythrocyte membrane protein
band 4.2, to Na-K ATPase, to the lymphocyte membrane protein GP85, and to the cytoskeletal proteins fodrin,
tubulin, vimentin and desmin. Erythrocyte ankyrins also link spectrin (beta chain) to the cytoplasmic domain of
the erythrocytes anion exchange protein; they retain most or all of these binding functions
Function: Isoform Mu17 together with obscurin in skeletal muscle may provide a molecular link between the
sarcoplasmic reticulum and myofibrils

Gene Wiki entry for ANK1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000008.10  NT_167187.2  NC_018919.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ANK1 gene promoter:
         TBP   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ANK1 promoter sequence
   Search Chromatin IP Primers for ANK1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ANK1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p11.1   Ensembl cytogenetic band:  8p11.21   HGNC cytogenetic band: 8p11.21

ANK1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ANK1 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M041510:  view genomic region     (about GC identifiers)

Start:
41,510,739 bp from pter      End:
41,754,280 bp from pter
Size:
243,542 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: ANK1_HUMAN, P16157 (See protein sequence)
Recommended Name: Ankyrin-1  
Size: 1881 amino acids; 206265 Da
Subunit: Interacts with a number of integral membrane proteins and cytoskeletal proteins. Interacts (via
N-terminus) with SPTB/spectrin (beta chain). Interacts (via N-terminus ANK repeats) with SLC4A1/erythrocyte
membrane protein band 3 (via cytoplasmic N-terminus). Also interacts with TTN/titin. Isoform Mu17 interacts with
OBSCN isoform 3/obscurin. Interacts with HIF1AN
Sequence caution: Sequence=AAB47805.1; Type=Erroneous gene model prediction;
Selected PDB 3D structures from and Proteopedia for ANK1 (see all 8):
1N11 (3D)        2YQF (3D)        2YVI (3D)        3F59 (3D)        3KBT (3D)        3KBU (3D)    
Secondary accessions: A0PJN8 A6NJ23 E5RFL7 O43400 Q13768 Q53ER1 Q59FP2 Q8N604 Q99407
Alternative promoter usage, Alternative splicing: 23 isoforms:  P16157-1   P16157-4   P16157-5   P16157-6   P16157-3   P16157-7   P16157-8   P16157-9   
P16157-10   P16157-11   P16157-12   P16157-13   P16157-14   P16157-15   P16157-16   P16157-2   
P16157-17   P16157-18   P16157-19   P16157-20   P16157-21   P16157-22   P16157-23   (Produced by alternative splicing)

Explore the universe of human proteins at neXtProt for ANK1: NX_P16157

Explore proteomics data for ANK1 at MOPED

Post-translational modifications: 

  • Regulated by phosphorylation1
  • Palmitoylated1
  • Hydroxylated by HIF1AN at several asparagine and 1 aspartate residue within ANK repeat region. Hydroxylation seems
    to increase the conformational stability of this region and may also modulate protein-protein interactions
    mediated by the ANK repeat region1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ANK1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (8 alternative transcripts): 
    NP_000028.3  NP_001135917.1  NP_001135918.1  NP_065208.2  NP_065209.2  NP_065210.2  NP_065211.2  NP_065213.2  

    ENSEMBL proteins: 
     ENSP00000339620   ENSP00000289734   ENSP00000428750   ENSP00000430368   ENSP00000319123  
     ENSP00000430174   ENSP00000265709   ENSP00000297744   ENSP00000335031   ENSP00000428315  
     ENSP00000369082   ENSP00000380149   ENSP00000403589   ENSP00000380147   ENSP00000309131  
    Reactome Protein details: P16157

    ANK1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for ANK1
    OriGene Protein Over-expression Lysate for ANK1
    OriGene MassSpec for ANK1
    OriGene Custom Protein Services for ANK1
    GenScript Custom Purified and Recombinant Proteins Services for ANK1
    Novus Biologicals ANK1 Protein
    Novus Biologicals ANK1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ANK1

     
    Search eBioscience for Proteins for ANK1 

     
    antibodies-online proteins for ANK1 (2 products) 

     
    antibodies-online peptides for ANK1

    ANK1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of ANK1
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for ANK1
    Novus Biologicals ANK1 Antibodies
    Abcam antibodies for ANK1
    Cloud-Clone Corp. Antibodies for ANK1
    ThermoFisher Antibodies for ANK1
    antibodies-online antibodies for ANK1 (14 products) 

    ANK1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ANK1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ANK1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ANK1
    Cloud-Clone Corp. CLIAs for ANK1
    Search eBioscience for ELISAs for ANK1 
    antibodies-online kits for ANK1 (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    ANKRD: Ankyrin repeat domain containing

    5 InterPro protein domains:
     IPR011029 DEATH-like_dom
     IPR000906 ZU5
     IPR002110 Ankyrin_rpt
     IPR000488 Death_domain
     IPR020683 Ankyrin_rpt-contain_dom

    Graphical View of Domain Structure for InterPro Entry P16157

    ProtoNet protein and cluster: P16157

    3 Blocks protein domains:
    IPB000488 Death domain
    IPB000906 ZU5 domain
    IPB002110 Ankyrin repeat signature


    UniProtKB/Swiss-Prot: ANK1_HUMAN, P16157
    Domain: The 55 kDa regulatory domain is involved in regulating binding of SPTB/spectrin (beta chain) and
    SLC4A1/erythrocyte membrane protein band 3
    Domain: The ANK repeat region forms a spiral around a large central cavity and is involved in binding of ion
    transporters
    Domain: The tandem configuration of the two ZU5 and the UPA domains forms a structural supramodule termed ZZU.
    ZU5-1 mediates interaction with beta-spectrin, and the ZU5-1/UPA interface is required for ankyrin's function
    other than binding to spectrin (By similarity)
    Similarity: Contains 23 ANK repeats
    Similarity: Contains 1 death domain
    Similarity: Contains 2 ZU5 domains


    Find genes that share domains with ANK1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ANK1_HUMAN, P16157
    Function: Attaches integral membrane proteins to cytoskeletal elements; binds to the erythrocyte membrane protein
    band 4.2, to Na-K ATPase, to the lymphocyte membrane protein GP85, and to the cytoskeletal proteins fodrin,
    tubulin, vimentin and desmin. Erythrocyte ankyrins also link spectrin (beta chain) to the cytoplasmic domain of
    the erythrocytes anion exchange protein; they retain most or all of these binding functions
    Function: Isoform Mu17 together with obscurin in skeletal muscle may provide a molecular link between the
    sarcoplasmic reticulum and myofibrils

         Genatlas biochemistry entry for ANK1:
    ankyrin 1,206kDa,erythrocyte membrane protein,intermediate filament associated protein (IFAP,type III),also
    expressed in neural tissue and skeletal muscle

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005198structural molecule activity NAS9430667
    GO:0005200structural constituent of cytoskeleton TAS8640229
    GO:0005515protein binding IPI12527750
    GO:0008093cytoskeletal adaptor activity TAS11427698
    GO:0019899enzyme binding TAS11427698
         
    Find genes that share ontologies with ANK1           About GenesLikeMe


    Phenotypes:
         14 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Ank1):
     behavior/neurological  cardiovascular system  growth/size/body  hematopoietic system  homeostasis/metabolism 
     immune system  integument  liver/biliary system  mortality/aging  nervous system 
     pigmentation  renal/urinary system  reproductive system  skeleton 

    Find genes that share phenotypes with ANK1           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for ANK1

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat ANK1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ANK1 (see all 84):
    hsa-miR-607 hsa-miR-128 hsa-miR-759 hsa-miR-4267 hsa-miR-10b* hsa-miR-877* hsa-miR-890 hsa-miR-149
    SwitchGear 3'UTR luciferase reporter plasmidANK1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ANK1
    Predesigned siRNA for gene silencing in human, mouse, rat ANK1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ANK1

    Clone
    Products:
         
    OriGene clones in human, mouse for ANK1 (see all 37)
    OriGene ORF clones in mouse, rat for ANK1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 8): ANK1 (NM_020475)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ANK1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ANK1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ANK1
    Browse ESI BIO Cell Lines and PureStem Progenitors for ANK1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANK1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    ANK1_HUMAN, P16157: Isoform Er1: Cytoplasm, cytoskeleton. Note=Probably the other erythrocyte (Er) isoforms, are
    located near the surface of erythrocytic plasma membrane
    ANK1_HUMAN, P16157: Isoform Mu17: Membrane. Cytoplasm, myofibril, sarcomere, M line. Note=Colocalizes with OBSCN
    isoform 3/obscurin at the M line in differentiated skeletal muscle cells
    ANK1_HUMAN, P16157: Isoform Mu18: Sarcoplasmic reticulum (Probable)
    ANK1_HUMAN, P16157: Isoform Mu19: Sarcoplasmic reticulum (Probable)
    ANK1_HUMAN, P16157: Isoform Mu20: Sarcoplasmic reticulum (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    plasma membrane5
    cytosol4
    endoplasmic reticulum4
    nucleus3
    extracellular2
    golgi apparatus2
    endosome1

    Gene Ontology (GO): Selected cellular component terms (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005829cytosol TAS--
    GO:0005856cytoskeleton NAS1833445
    GO:0005886plasma membrane NAS9430667
    GO:0014731spectrin-associated cytoskeleton IDA379653

    Find genes that share ontologies with ANK1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for ANK1 About    
    See pathways by source

    SuperPathContained pathways About
    1L1CAM interactions
    Axon guidance0.63
    CHL1 interactions0.00
    Developmental Biology0.63
    Neurofascin interactions0.00
    L1CAM interactions0.36
    NrCAM interactions0.00
    2Apoptotic Pathways in Synovial Fibroblasts
    Rac1 Pathway0.65
    3Proteoglycans in cancer
    Proteoglycans in cancer
    4Interaction between L1 and Ankyrins
    Interaction between L1 and Ankyrins


    Find genes that share SuperPaths with ANK1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for ANK1
        Rac1 Pathway

    4 Reactome Pathways for ANK1
        Interaction between L1 and Ankyrins
    NrCAM interactions
    CHL1 interactions
    Neurofascin interactions


    1 Kegg Pathway  (Kegg details for ANK1):
        Proteoglycans in cancer

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ANK1
    Interactions:

        GeneGlobe Interaction Network for ANK1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ANK1 (P161571, 2, 3 ENSP000002657094) via UniProtKB, MINT, STRING, and/or I2D (see all 39)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    OBSCNQ5VST9-31, ENSP000004094934EBI-941819,EBI-941921 MINT-50079 MINT-50077 MINT-50078 MINT-50080 MINT-50083 I2D: score=3 STRING: ENSP00000409493
    RHAGQ020943, ENSP000003602174I2D: score=2 STRING: ENSP00000360217
    EPB42P164523, ENSP000003002154I2D: score=1 STRING: ENSP00000300215
    NFASCO948563, ENSP000003531544I2D: score=1 STRING: ENSP00000353154
    SPTBP112773, ENSP000003743724I2D: score=1 STRING: ENSP00000374372
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006779porphyrin-containing compound biosynthetic process IEA--
    GO:0006887exocytosis NAS1833445
    GO:0006888ER to Golgi vesicle-mediated transport IDA18768923
    GO:0007010cytoskeleton organization NAS9430667
    GO:0007165signal transduction IEA--

    Find genes that share ontologies with ANK1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ANK1

    6 Novoseek inferred chemical compound relationships for ANK1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    phosphatidylethanolamine 29.2 2 15171729 (1), 9931302 (1)
    phosphatidylserine 23.7 1 15746942 (1)
    phosphatidylcholine 23.5 5 12175923 (1), 2170369 (1)
    lipid 3.03 1 15171729 (1)
    zinc 0 3 9819391 (2), 12913000 (1)
    tyrosine 0 2 17428854 (1)



    Find genes that share compounds with ANK1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for ANK1 gene (10 alternative transcripts): 
    NM_000037.3  NM_001142445.1  NM_001142446.1  NM_020475.2  NM_020476.2  NM_020477.2  NM_020478.4  NM_020480.4  
    NM_020479.2  NM_020481.2  

    Unigene Cluster for ANK1:

    Ankyrin 1, erythrocytic
    Hs.654438  [show with all ESTs]
    Unigene Representative Sequence: NM_001142446
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):
    ENST00000347528(uc003xoj.3 uc003xok.3 uc003xol.3 uc003xom.3)
    ENST00000289734(uc003xoh.3 uc003xoi.3) ENST00000522231 ENST00000522543
    ENST00000314214 ENST00000520299 ENST00000265709 ENST00000348036 ENST00000524227
    ENST00000335651 ENST00000518715 ENST00000518061 ENST00000524069 ENST00000521407
    ENST00000379758 ENST00000396945 ENST00000457297(uc011lcl.2 uc003xod.3 uc003xoc.3 uc003xof.3)
    ENST00000396942
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ANK1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ANK1 (see all 84):
    hsa-miR-607 hsa-miR-128 hsa-miR-759 hsa-miR-4267 hsa-miR-10b* hsa-miR-877* hsa-miR-890 hsa-miR-149
    SwitchGear 3'UTR luciferase reporter plasmidANK1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ANK1
    Predesigned siRNA for gene silencing in human, mouse, rat ANK1
    Clone
    Products:
         
    OriGene clones in human, mouse for ANK1 (see all 37)
    OriGene ORF clones in mouse, rat for ANK1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 8): ANK1 (NM_020475)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ANK1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ANK1
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for ANK1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ANK1
      QuantiTect SYBR Green Assays in human, mouse, rat ANK1
      QuantiFast Probe-based Assays in human, mouse, rat ANK1

    Additional mRNA sequence: 

    AB209418.1 AK126647.1 AK223578.1 BC007930.2 BC014467.1 BC030957.1 BC117121.1 BX647936.1 
    M28880.1 X16609.1 

    15 DOTS entries:

    DT.100751174  DT.102844156  DT.91775389  DT.91775385  DT.91775421  DT.100671224  DT.102844157  DT.95141964 
    DT.100751175  DT.100745555  DT.446414  DT.91775424  DT.91849266  DT.75102807  DT.40113153 

    Selected AceView cDNA sequences (see all 127):

    BU192234 AI659683 AI092367 AA464755 CA433323 AA477644 AI801936 CA396213 
    AI420193 AA326571 BQ718623 T58012 AK126647 BC014467 T28060 AA422077 
    BM909053 BC030957 AW044553 BF306541 AI383950 BV207421 NM_020476 AK129864 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ANK1 (see all 12)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^
    SP1:                                                                                                                                            -               
    SP2:                                                                                                                                            -               
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 26a · 26b ^ 27a · 27b ^ 28 ^ 29a · 29b ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35 ^ 36 ^ 37 ^ 38 ^ 39 ^ 40 ^ 41 ^ 42 ^ 43 ^ 44a · 44b · 44c · 44d · 44e ^
    SP1:  -     -                                                                                                                 -     -     -     -     -     -   
    SP2:  -     -                                                                                                                 -     -     -     -     -     -   
    SP3:  -     -                                                                                                                 -     -     -     -     -     -   
    SP4:  -     -                                                                                               -                 -     -     -     -     -     -   
    SP5:                                                                                                                          -     -     -     -     -     -   

    ExUns: 45 ^ 46a · 46b · 46c ^ 47a · 47b ^ 48a · 48b · 48c · 48d · 48e
    SP1:              -     -                                             
    SP2:                    -     -     -                                 
    SP3:              -     -     -     -                                 
    SP4:              -     -                                             
    SP5:                                                                  


    ECgene alternative splicing isoforms for ANK1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    ANK1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGGCTTCCT
    ANK1 Expression
    About this image


    ANK1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Pre-Granulosa Cells Primordial Follicle
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Proerythroblasts Hematopoietic Bone Marrow
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Mononuclear Myocytes Hyoid Arch Muscles
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Heart (Cardiovascular System)
    ANK1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ANK1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.654438

    UniProtKB/Swiss-Prot: ANK1_HUMAN, P16157
    Tissue specificity: Isoform Mu17, isoform Mu18, isoform Mu19 and isoform Mu20 are expressed in skeletal muscle.
    Isoform Br21 is expressed in brain

        Custom PCR Arrays for ANK1
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for ANK1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ANK1
    QuantiTect SYBR Green Assays in human, mouse, rat ANK1
    QuantiFast Probe-based Assays in human, mouse, rat ANK1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANK1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for ANK1 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ank11 , 5 ankyrin 1, erythroid1, 5 86.33(n)1
    91.73(a)1
      8 (11.42 cM)5
    117331  NM_001110783.31  NP_001104253.11 
     229748445 
    chicken
    (Gallus gallus)
    Aves ANK11 ankyrin 1, erythrocytic 78.51(n)
    84.22(a)
      396311  XM_424401.4  XP_424401.4 
    lizard
    (Anolis carolinensis)
    Reptilia ANK16
    ankyrin 1, erythrocytic
    79(a)
    1 ↔ 1
    GL343545.1(971-121593)
    African clawed frog
    (Xenopus laevis)
    Amphibia BJ064997.12   -- 77.41(n)    BJ064997.1 
    zebrafish
    (Danio rerio)
    Actinopterygii si:ch211-263m18.31 si:ch211-263m18.3 68(n)
    71.68(a)
      797662  XM_005161238.1  XP_005161295.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Ank23 cytoskeletal anchoring cytoskeletal
    protein binding
    53(a)
    (best of 3)
      66A10   --
    worm
    (Caenorhabditis elegans)
    Secernentea Y71A12B.43   -- 30(a)
    (best of 2)
      I(13910265-13921903)   --


    ENSEMBL Gene Tree for ANK1 (if available)
    TreeFam Gene Tree for ANK1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for ANK1 gene
    TNKS22  ANK32  ANKRD522  TNKS2  ANKRD652  ANKFY12  ANKRD502  INVS2  
    ANKRD282  ANK22  
    Selected SIMAP similar genes for ANK1 using alignment to 5 protein entries:     ANK1_HUMAN (see all proteins) (see all similar genes):
    hANK1    ANK3    GABPB1    ANK2    ANKRD44    IkBa
    ACAP3    CDKN2D    PPP1R12A    DKFZp686M09125    ANKRD54    PSMD10
    DKFZp434B2328    DKFZp761E1322    MTPN    ANKRD29    CDKN2C    NRARP

    Find genes that share paralogs with ANK1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for ANK1 (see all 5669)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0005964
    Spherocytosis 1 (SPH1)4--see VAR_0005962 V I mis40--------
    VAR_0549924
    Spherocytosis 1 (SPH1)4--see VAR_0549922 I T mis40--------
    VAR_0356054
    A breast cancer sample4--see VAR_0356052 D H mis40--------
    VAR_0549914
    Spherocytosis 1 (SPH1)4--see VAR_0549912 L R mis40--------
    rs61505651,2
    C--40040309(+) TATCC-/ACAGCA
    GAGTCTAT
    ACAGC
    8 -- ut310--------
    rs579632341,2
    C--40040314(+) ACAGC-/AGAGTC
    TATACAGC
    TTCAG
    8 -- ut310--------
    rs58911661,2
    C--40040397(+) TGTGT-/GT    
       
    /GTGT
    CCTGA
    16 -- ut310--------
    rs113055851,2
    C,F--40070897(+) TGTTAT/-TTTTT 5 -- int12Minor allele frequency- -:0.50NA CSA 4
    rs599854161,2
    C--40088701(+) TATAT-/ATATATATATATA/ATAT
    ATATATT
    /T/TATATAT/TT
    TTTTT
    5 -- int11NA 2
    rs106855421,2
    C--40094390(+) ACAAA-/CAAA/ 
    CAAACAAA
    ATCCA
    5 -- int11NA 2

    HapMap Linkage Disequilibrium report for ANK1 (41510739 - 41754280 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for ANK1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2736933CNV Deletion23290073
    esv2676408CNV Deletion23128226
    nsv831299CNV Loss17160897
    nsv818620CNV Loss17921354
    nsv831300CNV Loss17160897
    nsv890844CNV Loss21882294
    nsv824614CNV Loss20364138

    Human Gene Mutation Database (HGMD): ANK1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ANK1
    DNA2.0 Custom Variant and Variant Library Synthesis for ANK1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 612641   
    OMIM disorders: 182900  
    UniProtKB/Swiss-Prot: ANK1_HUMAN, P16157
  • Spherocytosis 1 (SPH1) [MIM:182900]: Spherocytosis is a hematologic disorder leading to chronic hemolytic
    anemia and characterized by numerous abnormally shaped erythrocytes which are generally spheroidal. SPH1 is
    characterized by severe hemolytic anemia. Inheritance is autosomal recessive. Note=The disease is caused by
    mutations affecting the gene represented in this entry

  • 6 diseases for ANK1:    
    About MalaCards
    8p11.2 deletion syndrome    hereditary spherocytosis    ank1-related spherocytosis    spherocytosis, hereditary, type 5
    hereditary elliptocytosis    bardet-biedl syndrome 5

    3 diseases from the University of Copenhagen DISEASES database for ANK1:
    Hereditary elliptocytosis     Anemia     Cowpox

    Find genes that share disorders with ANK1           About GenesLikeMe

    6 Novoseek inferred disease relationships for ANK1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    spherocytosis hereditary 92.4 19 16518602 (2), 9470011 (2), 16617750 (1), 17128827 (1) (see all 14)
    spherocytosis 82 4 9054656 (2), 8703812 (1), 12719424 (1)
    human granulocytic ehrlichiosis 62.2 1 10921951 (1)
    anemia hemolytic 57.9 2 9235914 (1)
    erythroleukemia 28 1 12489996 (1)
    tumors 4 2 11717987 (1), 7970728 (1)

    Genetic Association Database (GAD): ANK1
    Human Genome Epidemiology (HuGE) Navigator: ANK1 (5 documents)

    Export disorders for ANK1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for ANK1 gene, integrated from 10 sources (see all 166):
    (articles sorted by number of sources associating them with ANK1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. cDNA sequence for human erythrocyte ankyrin. (PubMed id 1689849)1, 2, 3, 9 Lambert S.... Palek J. (Proc. Natl. Acad. Sci. U.S.A. 1990)
    2. Ankyrin-1 mutations are a major cause of dominant and recessive hereditary spherocytosis. (PubMed id 8640229)1, 2, 9 Eber S.W.... Lux S.E. (Nat. Genet. 1996)
    3. Structure and organization of the human ankyrin-1 gene. Basis for complexity of pre-mRNA processing. (PubMed id 9235914)1, 2, 9 Gallagher P.G.... Forget B.G. (J. Biol. Chem. 1997)
    4. [Polymorphism analysis of G199A, Ncol in ANK1 and Memphis I in SLC4A1 genes in Mexican healthy individuals and subjects affected with hereditary spherocytosis]. (PubMed id 17128827)1, 4, 9 Camacho-Torres A.L....Perea-DA-az F.J. (Gac Med Mex 2006)
    5. An alternate promoter directs expression of a truncated, muscle- specific isoform of the human ankyrin 1 gene. (PubMed id 9430667)1, 2, 9 Gallagher P.G. and Forget B.G. (J. Biol. Chem. 1998)
    6. Mapping the binding sites of human erythrocyte ankyrin for the anion exchanger and spectrin. (PubMed id 2141335)1, 2, 9 Davis L.H. and Bennett V. (J. Biol. Chem. 1990)
    7. Analysis of cDNA for human erythrocyte ankyrin indicates a repeated structure with homology to tissue-differentiation and cell-cycle control proteins. (PubMed id 2137557)1, 2, 9 Lux S.E.... Bennett V. (Nature 1990)
    8. A single-nucleotide polymorphism in ANK1 is associated with susceptibility to type 2 diabetes in Japanese populations. (PubMed id 22456796)1, 4 Imamura M....Kadowaki T. (Hum. Mol. Genet. 2012)
    9. Genome-wide association study of lung function decline in adults with and without asthma. (PubMed id 22424883)1, 4 Imboden M....Probst-Hensch N.M. (J. Allergy Clin. Immunol. 2012)
    10. Asparagine and aspartate hydroxylation of the cytoskeletal ankyrin family is catalyzed by factor-inhibiting hypoxia-inducible factor. (PubMed id 21177872)1, 2 Yang M.... Schofield C.J. (J. Biol. Chem. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 286 HGNC: 492 AceView: ANK1 Ensembl:ENSG00000029534 euGenes: HUgn286
    ECgene: ANK1 Kegg: 286 H-InvDB: ANK1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for ANK1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ANK1 Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/Ankyrin

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for ANK1 gene:
    Search GeneIP for patents involving ANK1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Small Molecules at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of ANK1
     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for ANK1  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for ANK1  
     OriGene MassSpec for ANK1   OriGene clones in human, mouse for ANK1  
     OriGene qSTAR qPCR primer pairs in human, mouse for ANK1   OriGene Purified Protein for ANK1  
     OriGene ORF clones in mouse, rat for ANK1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ANK1   OriGene Custom Protein Services for ANK1  

     
     
     Block miRNA regulation of human, mouse, rat ANK1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing ANK1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ANK1 Predesigned siRNA for gene silencing in human, mouse, rat ANK1
     QuantiFast Probe-based Assays in human, mouse, rat ANK1 QuantiTect SYBR Green Assays in human, mouse, rat ANK1
     Custom PCR Arrays for ANK1 Search Chromatin IP Primers for ANK1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ANK1  GeneGlobe Interaction Network for ANK1
     Regulatory tfbs in ANK1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for ANK1 GenScript cDNA clones with any tag delivered in your preferred vector for ANK1
     GenScript Custom Assay Services for ANK1 GenScript Custom overexpressing Cell Line Services for ANK1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for ANK1
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     ANK1 antibodies
     ANK1 proteins
     ANK1 lysates
     Antibodies for ANK1
     See all of Abcam's Antibodies, Kits and Proteins for ANK1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for ANK1
     Antibodies for ANK1
     ELISAs for ANK1
     CLIAs for ANK1



     Browse ESI BIO Cell Lines and PureStem Progenitors for ANK1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANK1
     SwitchGear 3'UTR luciferase reporter plasmids for ANK1
     SwitchGear Promoter luciferase reporter plasmids for ANK1
     ThermoFisher Antibodies for ANK1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ANK1
     Browse compounds at ApexBio
     Search Addgene for plasmids for ANK1
      Search eBioscience for proteins for ANK1
      Search eBioscience for elisas for ANK1
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for ANK1
     antibodies-online antibodies for ANK1 (14 products)
     antibodies-online kits for ANK1 (4 products)
     antibodies-online peptides for ANK1
     antibodies-online proteins for ANK1 (2 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      ANK1 gene at Home site.
    Version: 3.12.258 10 Dec 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4