Aliases for ANGPTL8 Gene
Aliases for ANGPTL8 Gene
External Ids for ANGPTL8 Gene
- HGNC: 24933
- Entrez Gene: 55908
- Ensembl: ENSG00000130173
- OMIM: 616223
- UniProtKB: Q6UXH0
Previous HGNC Symbols for ANGPTL8 Gene
- C19orf80
Summaries for ANGPTL8 Gene
GeneCards Summary for ANGPTL8 Gene
ANGPTL8 (Angiopoietin Like 8) is a Protein Coding gene. Diseases associated with ANGPTL8 include Breast Angiosarcoma and Breast Sarcoma. Among its related pathways are Lipoprotein metabolism and Metabolism.
UniProtKB/Swiss-Prot for ANGPTL8 Gene
-
Hormone that acts as a blood lipid regulator by regulating serum triglyceride levels (PubMed:22569073, PubMed:22809513, PubMed:23150577). May be involved in the metabolic transition between fasting and refeeding: required to direct fatty acids to adipose tissue for storage in the fed state (By similarity).
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANGPTL8 Gene
Genomics for ANGPTL8 Gene
Regulatory Elements for ANGPTL8 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH19G011202 | 1.4 | Ensembl ENCODE dbSUPER | 12.8 | -33.7 | -33741 | 3.1 | ZNF48 GATA2 ZNF143 FOS ZNF263 REST MEF2D SMARCA4 GLIS1 NR2C1 | ZNF627 ZNF844 ZNF136 ZNF625 ANGPTL8 DOCK6 HNRNPA1P10 ZNF763 ZNF439 ZNF433 |
| GH19G011234 | 0.7 | ENCODE | 0.7 | -2.8 | -2791 | 0.2 | ZNF280D ATF1 ZMYM3 ZNF623 ATF2 YY1 JUND ZFHX2 EGR1 ADNP | GC19M011233 ANGPTL8 |
Regulatory Element Products
Genomic Location for ANGPTL8 Gene
- Chromosome:
- 19
- Start:
- 11,237,450 bp from pter
- End:
- 11,241,943 bp from pter
- Size:
- 4,494 bases
- Orientation:
- Plus strand
Genomic View for ANGPTL8 Gene
- Cytogenetic band:
-
- 19p13.2 by Ensembl
- 19p13.2 by Entrez Gene
- 19p13.2 by HGNC
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ANGPTL8 Gene
Proteins for ANGPTL8 Gene
-
Protein details for ANGPTL8 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q6UXH0-ANGL8_HUMAN
- Recommended name:
- Angiopoietin-like protein 8
- Protein Accession:
- Q6UXH0
- Q9NQZ1
Protein attributes for ANGPTL8 Gene
- Size:
- 198 amino acids
- Molecular mass:
- 22105 Da
- Quaternary structure:
-
- Interacts with ANGPTL3.
- SequenceCaution:
-
- Sequence=AAF76204.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=EAW84186.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
Post-translational modifications for ANGPTL8 Gene
- Proteolytically cleaved at the N-terminus.
Other Protein References for ANGPTL8 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for ANGPTL8 (Angiopoietin-like Protein 8/Betatrophin)
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-
Abcam antibodies for ANGPTL8
-
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- GeneTex ANGPTL8 antibody for ANGPTL8
-
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Protein Products
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OriGene Purified Proteins for ANGPTL8
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ProSci Proteins for ANGPTL8
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Abcam proteins for ANGPTL8
Assay Products
-
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No data available for DME Specific Peptides for ANGPTL8 Gene
Domains & Families for ANGPTL8 Gene
Gene Families for ANGPTL8 Gene
- HGNC:
Graphical View of Domain Structure for InterPro Entry
Q6UXH0- Family:
-
- Belongs to the ANGPTL8 family.
No data available for Suggested Antigen Peptide Sequences for ANGPTL8 Gene
Function for ANGPTL8 Gene
Molecular function for ANGPTL8 Gene
- UniProtKB/Swiss-Prot Function:
- Hormone that acts as a blood lipid regulator by regulating serum triglyceride levels (PubMed:22569073, PubMed:22809513, PubMed:23150577). May be involved in the metabolic transition between fasting and refeeding: required to direct fatty acids to adipose tissue for storage in the fed state (By similarity).
- UniProtKB/Swiss-Prot Induction:
- In response to food intake. Stimulated by insulin.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005179 | hormone activity | ISS | -- |
| GO:0005515 | protein binding | IPI | 21988832 |
Phenotypes for ANGPTL8 Gene
- MGI mutant phenotypes for ANGPTL8:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for ANGPTL8:
Animal Model Products
-
Taconic Biosciences Mouse Models for ANGPTL8
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-
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CRISPR Products
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Clone Products
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- R&D Systems cDNA Clones for ANGPTL8 (Angiopoietin-like Protein 8/Betatrophin)
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for ANGPTL8 Gene
Localization for ANGPTL8 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ANGPTL8 Gene
- Secreted.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | TAS | -- |
Pathways & Interactions for ANGPTL8 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Lipoprotein metabolism | ||
| 2 | Metabolism |
.37
|
|
| 3 | Angiopoietin Like Protein 8 Regulatory Pathway | ||
Pathways by source for ANGPTL8 Gene
1 BioSystems pathway for ANGPTL8 Gene
5 Reactome pathways for ANGPTL8 Gene
Interacting Proteins for ANGPTL8 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006629 | lipid metabolic process | IEA | -- |
| GO:0010954 | positive regulation of protein processing | IDA | 23150577 |
| GO:0019216 | regulation of lipid metabolic process | IDA | 25417115 |
| GO:0042157 | lipoprotein metabolic process | TAS | -- |
| GO:0044255 | cellular lipid metabolic process | ISS,IEA | -- |
No data available for SIGNOR curated interactions for ANGPTL8 Gene
Transcripts for ANGPTL8 Gene
mRNA/cDNA for ANGPTL8 Gene
- (1) REFSEQ mRNAs :
- (15) Selected AceView cDNA sequences:
- (4) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for ANGPTL8
- GenScript: Design CRISPR guide RNA sequences for ANGPTL8
miRNA Products
- Search ViGene Biosciences for ANGPTL8
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for ANGPTL8
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Clone Products
-
OriGene ORF clones in human for ANGPTL8
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for ANGPTL8
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for ANGPTL8
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ANGPTL8
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- R&D Systems cDNA Clones for ANGPTL8 (Angiopoietin-like Protein 8/Betatrophin)
Flow Cytometry Products
Expression for ANGPTL8 Gene
NURSA nuclear receptor signaling pathways regulating expression of ANGPTL8 Gene:
ANGPTL8mRNA Expression by UniProt/SwissProt for ANGPTL8 Gene:
Q6UXH0-ANGL8_HUMANEvidence on tissue expression from TISSUES for ANGPTL8 Gene
- Liver(2.7)
- Pancreas(2.2)
Primer Products
-
OriGene qPCR primer pairs for ANGPTL8
No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ANGPTL8 Gene
Orthologs for ANGPTL8 Gene
This gene was present in the common ancestor of mammals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | C19H19orf80 34 |
|
||
| C19orf80 35 |
|
OneToOne | |||
| dog (Canis familiaris) |
Mammalia | C20H19orf80 34 |
|
||
| C19orf80 35 |
|
OneToOne | |||
| cow (Bos Taurus) |
Mammalia | C7H19orf80 34 |
|
||
| C19orf80 35 |
|
OneToOne | |||
| mouse (Mus musculus) |
Mammalia | Gm6484 34 35 |
|
||
| Angptl8 16 |
|
||||
| rat (Rattus norvegicus) |
Mammalia | LOC100361444 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | C19orf80 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | C19orf80 35 |
|
OneToOne |
- Species where no ortholog for ANGPTL8 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for ANGPTL8 Gene
No data available for Paralogs for ANGPTL8 Gene
Variants for ANGPTL8 Gene
| SNP ID | Clin | Chr 19 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000036199 | -- | 11,241,128(+) | GTAGT(A/C)CCAGC | intron-variant | |
| rs1000903662 | -- | 11,241,798(+) | GGCGC(A/C/T)GGGCC | intron-variant, utr-variant-3-prime | |
| rs1001208423 | -- | 11,240,732(+) | ACCAG(C/T)TAATT | intron-variant | |
| rs1002643598 | -- | 11,239,564(+) | ATTGA(C/G)TGGGG | intron-variant, upstream-variant-2KB | |
| rs1002868063 | -- | 11,239,309(+) | TAAAA(C/T)CTTTA | intron-variant, upstream-variant-2KB |
Relevant External Links for ANGPTL8 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANGPTL8 Gene
Disorders for ANGPTL8 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| breast angiosarcoma |
|
|
| breast sarcoma |
|
|
| diabetes mellitus, insulin-dependent |
|
|
UniProtKB/Swiss-Prot
ANGL8_HUMAN- Diabetes mellitus, insulin-dependent (IDDM) [MIM:222100]: A multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical features are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels. {ECO:0000305 PubMed:24078058}. Note=The gene represented in this entry may be involved in disease pathogenesis. Increased protein levels are observed in the serum of patients. This result should however be reinvestigated in light of recent advances that suggest that this protein is not promoting pancreatic beta cell proliferation. {ECO:0000305 PubMed:24078058}.
- Diabetes mellitus, non-insulin-dependent (NIDDM) [MIM:125853]: A multifactorial disorder of glucose homeostasis caused by a lack of sensitivity to the bodys own insulin. Affected individuals usually have an obese body habitus and manifestations of a metabolic syndrome characterized by diabetes, insulin resistance, hypertension and hypertriglyceridemia. The disease results in long-term complications that affect the eyes, kidneys, nerves, and blood vessels. {ECO:0000305 PubMed:24852694, ECO:0000305 PubMed:24963292, ECO:0000305 PubMed:25024395, ECO:0000305 PubMed:25303484}. Note=The gene represented in this entry may be involved in disease pathogenesis. Increased protein levels are observed in the serum of patients and are associated with insulin resistance (PubMed:25024395, PubMed:25303484, PubMed:24963292, PubMed:24852694). According to another report, protein levels are decreased in the serum of patients (PubMed:25050901). Discrepancies between increased and decreased levels of proteins levels in NIDDM patients may be explained by the use of different kits developed on the market that either use antibodies recognizing the N-terminal or the C-terminal part of the protein (PubMed:25099942). These results should however be reinvestigated in light of recent advances that suggest that this protein is not promoting pancreatic beta cell proliferation. {ECO:0000305 PubMed:24852694, ECO:0000305 PubMed:24963292, ECO:0000305 PubMed:25024395, ECO:0000305 PubMed:25050901, ECO:0000305 PubMed:25099942, ECO:0000305 PubMed:25303484}.
Relevant External Links for ANGPTL8
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- ANGPTL8
No data available for Genatlas for ANGPTL8 Gene
Publications for ANGPTL8 Gene
- Lipasin, a novel nutritionally-regulated liver-enriched factor that regulates serum triglyceride levels. (PMID: 22809513) Zhang R. (Biochem. Biophys. Res. Commun. 2012) 2 3 4 64
- Atypical angiopoietin-like protein that regulates ANGPTL3. (PMID: 23150577) Quagliarini F. … Hobbs H.H. (Proc. Natl. Acad. Sci. U.S.A. 2012) 2 3 4 64
- Circulating betatrophin levels are increased in patients with type 2 diabetes and associated with insulin resistance. (PMID: 25303484) Chen X. … Yu X. (J. Clin. Endocrinol. Metab. 2015) 3 4 64
- Chromosome 19 open reading frame 80 is upregulated by thyroid hormone and modulates autophagy and lipid metabolism. (PMID: 24262987) Tseng Y.H. … Lin K.H. (Autophagy 2014) 2 3 64
- Elevated circulating lipasin/betatrophin in human type 2 diabetes and obesity. (PMID: 24852694) Fu Z. … Zhang R. (Sci. Rep. 2014) 3 4 64
Products for ANGPTL8 Gene
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- VectorBuilder custom plasmid, inducible vectors for ANGPTL8
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ANGPTL8
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for ANGPTL8 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
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- (28) RNAdb
- (29) ASD
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- (31) GeneAnnot
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- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
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- (42) dbSNP
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- (44) GeneTests
- (45) HGMD
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- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
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- (60) miRBase
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- (62) NCBI
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- (67) Tocris
- (68) Abcam
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- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
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- (80) neXtProt
- (81) Reactome
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