Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ANGPTL8 Gene

Aliases for ANGPTL8 Gene

  • Angiopoietin Like 8 2 3 5
  • Lipasin 2 3 4
  • Refeeding-Induced Fat And Liver Protein 3 4
  • Angiopoietin-Like 8 2 3
  • Betatrophin 2 4
  • C19orf80 3 4
  • RIFL 3 4
  • Hepatocellular Carcinoma-Associated Protein TD26 3
  • Hepatocellular Carcinoma-Associated Gene TD26 3
  • Chromosome 19 Open Reading Frame 80 2
  • Betatrophin Variant 1 3
  • Betatrophin Variant 2 3
  • PRO1185 3
  • PVPA599 3
  • TD26 3

External Ids for ANGPTL8 Gene

Previous HGNC Symbols for ANGPTL8 Gene

  • C19orf80

Summaries for ANGPTL8 Gene

GeneCards Summary for ANGPTL8 Gene

ANGPTL8 (Angiopoietin Like 8) is a Protein Coding gene. Diseases associated with ANGPTL8 include breast angiosarcoma and breast sarcoma.

UniProtKB/Swiss-Prot for ANGPTL8 Gene

  • Hormone that acts as a blood lipid regulator by regulating serum triglyceride levels (PubMed:22569073, PubMed:22809513, PubMed:23150577). May be involved in the metabolic transition between fasting and refeeding: required to direct fatty acids to adipose tissue for storage in the fed state (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANGPTL8 Gene

Genomics for ANGPTL8 Gene

Regulatory Elements for ANGPTL8 Gene

Promoters for ANGPTL8 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ANGPTL8 on UCSC Golden Path with GeneCards custom track

Genomic Location for ANGPTL8 Gene

Chromosome:
19
Start:
11,237,450 bp from pter
End:
11,241,943 bp from pter
Size:
4,494 bases
Orientation:
Plus strand

Genomic View for ANGPTL8 Gene

Genes around ANGPTL8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANGPTL8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANGPTL8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANGPTL8 Gene

Proteins for ANGPTL8 Gene

  • Protein details for ANGPTL8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UXH0-ANGL8_HUMAN
    Recommended name:
    Angiopoietin-like protein 8
    Protein Accession:
    Q6UXH0
    Secondary Accessions:
    • Q9NQZ1

    Protein attributes for ANGPTL8 Gene

    Size:
    198 amino acids
    Molecular mass:
    22105 Da
    Quaternary structure:
    • Interacts with ANGPTL3.
    SequenceCaution:
    • Sequence=AAF76204.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=EAW84186.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for ANGPTL8 Gene

Proteomics data for ANGPTL8 Gene at MOPED

Post-translational modifications for ANGPTL8 Gene

Other Protein References for ANGPTL8 Gene

No data available for DME Specific Peptides for ANGPTL8 Gene

Domains & Families for ANGPTL8 Gene

Gene Families for ANGPTL8 Gene

Protein Domains for ANGPTL8 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q6UXH0

UniProtKB/Swiss-Prot:

ANGL8_HUMAN :
  • Belongs to the ANGPTL8 family.
Family:
  • Belongs to the ANGPTL8 family.
genes like me logo Genes that share domains with ANGPTL8: view

No data available for Suggested Antigen Peptide Sequences for ANGPTL8 Gene

Function for ANGPTL8 Gene

Molecular function for ANGPTL8 Gene

UniProtKB/Swiss-Prot Function:
Hormone that acts as a blood lipid regulator by regulating serum triglyceride levels (PubMed:22569073, PubMed:22809513, PubMed:23150577). May be involved in the metabolic transition between fasting and refeeding: required to direct fatty acids to adipose tissue for storage in the fed state (By similarity).
UniProtKB/Swiss-Prot Induction:
In response to food intake. Stimulated by insulin.

Phenotypes for ANGPTL8 Gene

genes like me logo Genes that share phenotypes with ANGPTL8: view

Animal Models for ANGPTL8 Gene

MGI Knock Outs for ANGPTL8:

Animal Model Products

  • Taconic Biosciences Mouse Models for ANGPTL8

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for ANGPTL8 Gene

Localization for ANGPTL8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ANGPTL8 Gene

Secreted.

No data available for Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for ANGPTL8 Gene

Pathways & Interactions for ANGPTL8 Gene

SuperPathways for ANGPTL8 Gene

No Data Available

Interacting Proteins for ANGPTL8 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000252453%0d%0a9606.ENSP00000321239%0d%0a
Selected Interacting proteins: Q6UXH0-ANGL8_HUMAN ENSP00000252453 for ANGPTL8 Gene via UniProtKB STRING

Gene Ontology (GO) - Biological Process for ANGPTL8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019216 regulation of lipid metabolic process IEA,IDA 25417115
GO:0044255 cellular lipid metabolic process IEA,ISS --
GO:0048469 cell maturation IEA --
GO:0050746 regulation of lipoprotein metabolic process IEA,IMP 23150577
GO:0070328 triglyceride homeostasis IEA,IGI 23150577
genes like me logo Genes that share ontologies with ANGPTL8: view

No data available for Pathways by source and SIGNOR curated interactions for ANGPTL8 Gene

Drugs & Compounds for ANGPTL8 Gene

No Compound Related Data Available

Transcripts for ANGPTL8 Gene

mRNA/cDNA for ANGPTL8 Gene

(1) REFSEQ mRNAs :
(15) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for ANGPTL8 Gene

No ASD Table

Relevant External Links for ANGPTL8 Gene

GeneLoc Exon Structure for
ANGPTL8
ECgene alternative splicing isoforms for
ANGPTL8

Expression for ANGPTL8 Gene

mRNA Expression by UniProt/SwissProt for ANGPTL8 Gene

Q6UXH0-ANGL8_HUMAN
Tissue specificity: Predominantly expressed in liver. Also expressed in adipose tissues.

In Situ Assay Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for ANGPTL8 Gene

Orthologs for ANGPTL8 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ANGPTL8 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia C7H19orf80 35
  • 80.64 (n)
  • 69.19 (a)
C19orf80 36
  • 69 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C20H19orf80 35
  • 84.01 (n)
  • 77.27 (a)
C19orf80 36
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gm6484 35
  • 76.6 (n)
  • 72.73 (a)
Angptl8 16
Gm6484 36
  • 73 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia C19H19orf80 35
  • 99.49 (n)
  • 99.49 (a)
C19orf80 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100361444 35
  • 73.74 (n)
  • 68.69 (a)
oppossum
(Monodelphis domestica)
Mammalia C19orf80 36
  • 39 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C19orf80 36
  • 35 (a)
OneToOne
Species with no ortholog for ANGPTL8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ANGPTL8 Gene

ENSEMBL:
Gene Tree for ANGPTL8 (if available)
TreeFam:
Gene Tree for ANGPTL8 (if available)

Paralogs for ANGPTL8 Gene

No data available for Paralogs for ANGPTL8 Gene

Variants for ANGPTL8 Gene

Sequence variations from dbSNP and Humsavar for ANGPTL8 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
VAR_039046 -
VAR_039047 -

Variation tolerance for ANGPTL8 Gene

Gene Damage Index Score: 5.65; 72.75% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ANGPTL8 Gene

HapMap Linkage Disequilibrium report
ANGPTL8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ANGPTL8 Gene

Disorders for ANGPTL8 Gene

MalaCards: The human disease database

(3) MalaCards diseases for ANGPTL8 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
breast angiosarcoma
  • hemangiosarcoma of the breast
breast sarcoma
  • sarcoma of breast
diabetes mellitus, insulin-dependent
  • diabetes, type 1
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

ANGL8_HUMAN
  • Diabetes mellitus, insulin-dependent (IDDM) [MIM:222100]: A multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical features are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels. {ECO:0000305 PubMed:24078058}. Note=The gene represented in this entry may be involved in disease pathogenesis. Increased protein levels are observed in the serum of patients. This result should however be reinvestigated in light of recent advances that suggest that this protein is not promoting pancreatic beta cell proliferation. {ECO:0000305 PubMed:24078058}.
  • Diabetes mellitus, non-insulin-dependent (NIDDM) [MIM:125853]: A multifactorial disorder of glucose homeostasis caused by a lack of sensitivity to the bodys own insulin. Affected individuals usually have an obese body habitus and manifestations of a metabolic syndrome characterized by diabetes, insulin resistance, hypertension and hypertriglyceridemia. The disease results in long-term complications that affect the eyes, kidneys, nerves, and blood vessels. {ECO:0000305 PubMed:24852694, ECO:0000305 PubMed:24963292, ECO:0000305 PubMed:25024395, ECO:0000305 PubMed:25303484}. Note=The gene represented in this entry may be involved in disease pathogenesis. Increased protein levels are observed in the serum of patients and are associated with insulin resistance (PubMed:25024395, PubMed:25303484, PubMed:24963292, PubMed:24852694). According to another report, protein levels are decreased in the serum of patients (PubMed:25050901). Discrepancies between increased and decreased levels of proteins levels in NIDDM patients may be explained by the use of different kits developed on the market that either use antibodies recognizing the N-terminal or the C-terminal part of the protein (PubMed:25099942). These results should however be reinvestigated in light of recent advances that suggest that this protein is not promoting pancreatic beta cell proliferation. {ECO:0000305 PubMed:24852694, ECO:0000305 PubMed:24963292, ECO:0000305 PubMed:25024395, ECO:0000305 PubMed:25050901, ECO:0000305 PubMed:25099942, ECO:0000305 PubMed:25303484}.

Relevant External Links for ANGPTL8

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ANGPTL8
genes like me logo Genes that share disorders with ANGPTL8: view

No data available for Genatlas for ANGPTL8 Gene

Publications for ANGPTL8 Gene

  1. Atypical angiopoietin-like protein that regulates ANGPTL3. (PMID: 23150577) Quagliarini F. … Hobbs H.H. (Proc. Natl. Acad. Sci. U.S.A. 2012) 2 3 4 67
  2. Chromosome 19 open reading frame 80 is upregulated by thyroid hormone and modulates autophagy and lipid metabolism. (PMID: 24262987) Tseng Y.H. … Lin K.H. (Autophagy 2014) 2 3
  3. Lipasin, a novel nutritionally-regulated liver-enriched factor that regulates serum triglyceride levels. (PMID: 22809513) Zhang R. (Biochem. Biophys. Res. Commun. 2012) 2 3
  4. Circulating betatrophin levels are increased in patients with type 2 diabetes and associated with insulin resistance. (PMID: 25303484) Chen X. … Yu X. (J. Clin. Endocrinol. Metab. 2015) 3
  5. Betatrophin levels are increased in women with gestational diabetes mellitus compared to healthy pregnant controls. (PMID: 25850828) Ebert T. … Fasshauer M. (Eur. J. Endocrinol. 2015) 3

Products for ANGPTL8 Gene

Sources for ANGPTL8 Gene

Back to Top

Content