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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ANGPTL7 Gene

protein-coding   GIFtS: 49
GCID: GC01P011249

Angiopoietin-Like 7

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Angiopoietin-Like 71 2     RP4-647M16.22
Angiopoietin-Like Protein 72 3     Angiopoietin-Like Factor (CDT6)2
Cornea-Derived Transcript 6 Protein2 3     Angiopoietin-Related Protein 72
CDT62 3     dJ647M16.12
AngX2     Angiopoietin-Like Factor3

External Ids:    HGNC: 240781   Entrez Gene: 102182   Ensembl: ENSG000001718197   UniProtKB: O438273   

Export aliases for ANGPTL7 gene to outside databases

Previous GC identifers: GC01P011184 GC01P010400


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ANGPTL7 Gene: 
ANGPTL7 (angiopoietin-like 7) is a protein-coding gene. Diseases associated with ANGPTL7 include glaucoma. GO annotations related to this gene include receptor binding. An important paralog of this gene is FGL2.

Gene Wiki entry for ANGPTL7 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_021937.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ANGPTL7 gene promoter:
         NRSF form 1   MyoD   Olf-1   NRSF form 2   C/EBPalpha   Max   CHOP-10   FOXJ2 (long isoform)   FOXJ2   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidANGPTL7 promoter sequence
   Search SABiosciences Chromatin IP Primers for ANGPTL7

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ANGPTL7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36   Ensembl cytogenetic band:  1p36.22   HGNC cytogenetic band: 1p36

ANGPTL7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ANGPTL7 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P011249:  view genomic region     (about GC identifiers)

Start:
11,249,398 bp from pter      End:
11,256,038 bp from pter
Size:
6,641 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ANGL7_HUMAN, O43827 (See protein sequence)
Recommended Name: Angiopoietin-related protein 7 precursor  
Size: 346 amino acids; 40018 Da
Subcellular location: Secreted (Probable)
Secondary accessions: B2R9B2 Q4ZGK4

Explore the universe of human proteins at neXtProt for ANGPTL7: NX_O43827

Explore proteomics data for ANGPTL7 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O43827

  • ANGPTL7 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ANGPTL7 Protein Expression
    REFSEQ proteins: NP_066969.1  
    ENSEMBL proteins: 
     ENSP00000366015  

    Human Recombinant Protein Products for ANGPTL7: 
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    OriGene Protein Over-expression Lysate for ANGPTL7
    OriGene MassSpec for ANGPTL7 
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    Novus Biologicals ANGPTL7 Proteins
    Novus Biologicals ANGPTL7 Lysates
    Sino Biological Recombinant Protein for ANGPTL7
    Sino Biological Cell Lysate for ANGPTL7 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ANGPTL7 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--

    ANGPTL7 for ontologies           About GeneDecksing



    ANGPTL7 Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    FIBC: Fibrinogen C domain containing

    3 InterPro protein domains:
     IPR014715 Fibrinogen_a/b/g_C_2
     IPR002181 Fibrinogen_a/b/g_C_dom
     IPR014716 Fibrinogen_a/b/g_C_1

    Graphical View of Domain Structure for InterPro Entry O43827

    ProtoNet protein and cluster: O43827

    1 Blocks protein domain: IPB002181 Fibrinogen

    UniProtKB/Swiss-Prot: ANGL7_HUMAN, O43827
    Similarity: Contains 1 fibrinogen C-terminal domain


    ANGPTL7 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Phenotypes:
         1 MGI phenotypic allele for Angptl7 (no phenotypes)

    ANGPTL7 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Angptl7tm1Lex for ANGPTL7

       inGenious Targeting Laboratory - Custom generated mouse model solutions for ANGPTL7 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ANGPTL7

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ANGPTL7 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ANGPTL7 

    miRNA
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    5 QIAGEN miScript miRNA Assays for microRNAs that regulate ANGPTL7:
    hsa-miR-4254 hsa-miR-520d-5p hsa-miR-524-5p hsa-miR-3121-3p hsa-miR-2113
    SwitchGear 3'UTR luciferase reporter plasmidANGPTL7 3' UTR sequence
    Inhib. RNA
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANGPTL7


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ANGPTL7

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006979response to oxidative stress TAS8026862

    ANGPTL7 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ANGPTL7 (ANGL7)

    Search CenterWatch for drugs/clinical trials and news about ANGPTL7 / ANGL7

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ANGPTL7 gene: 
    NM_021146.3  

    Unigene Cluster for ANGPTL7:

    Angiopoietin-like 7
    Hs.146559  [show with all ESTs]
    Unigene Representative Sequence: NM_021146
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000376819(uc001ase.3) ENST00000476934
    miRNA
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    5 QIAGEN miScript miRNA Assays for microRNAs that regulate ANGPTL7:
    hsa-miR-4254 hsa-miR-520d-5p hsa-miR-524-5p hsa-miR-3121-3p hsa-miR-2113
    SwitchGear 3'UTR luciferase reporter plasmidANGPTL7 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ANGPTL7
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ANGPTL7
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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    Sirion Biotech Customized lentivirus for stable overexpression of ANGPTL7 
                         Customized lentivirus expression plasmids for stable overexpression of ANGPTL7 
    Primer
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    OriGene qPCR primer pairs and template standards for ANGPTL7
    OriGene qSTAR qPCR primer pairs in human, mouse for ANGPTL7
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ANGPTL7
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ANGPTL7

    Additional mRNA sequence: 

    AB593026.1 AB593027.1 AK313716.1 AY358301.1 BC001881.1 BT009802.1 Y16132.1 

    2 DOTS entries:

    DT.40272468  DT.101971229 

    24/81 AceView cDNA sequences (see all 81):

    BQ898135 AI278780 BQ898121 BM720771 BE276592 CD171903 BE389513 CD678813 
    CD676529 CD518252 CD513179 BM682673 CD679305 BE390279 CD678923 BE276843 
    BT009802 BE385232 CD517563 CA407625 AY358301 BX483048 BF025871 CA391009 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for ANGPTL7    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b
    SP1:                                                
    SP2:                          -                     


    ECgene alternative splicing isoforms for ANGPTL7

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ANGPTL7 expression in normal human tissues (normalized intensities)      ANGPTL7 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GATGCCGGCA
    ANGPTL7 Expression
    About this image


    ANGPTL7 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/8 selected tissues (see all 8) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 7 entries
             HyStem+BMP4-induced 4D20.8 cells
     
     Cartilage (Muscoskeletal System)    fully expand to see all 7 entries
             HyStem+BMP4-induced 4D20.8 cells
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             Human Trabecular Meshwork Cells (HTMC)   
     
     Hair
             hair follicle bulge   
     
     Dermis (Integumentary System)    fully expand to see all 2 entries
             hair follicle bulge   

    See ANGPTL7 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ANGPTL7

    SOURCE GeneReport for Unigene cluster: Hs.146559

    UniProtKB/Swiss-Prot: ANGL7_HUMAN, O43827
    Tissue specificity: Highly and specifically expressed in the cornea where is confined to the stromal layer

        SABiosciences Custom PCR Arrays for ANGPTL7
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANGPTL7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ANGPTL7 gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Angptl71 , 5 angiopoietin-like 71, 5 88.39(n)1
    88.89(a)1
      4 (78.76 cM)5
    6548121  NM_001039554.31  NP_001034643.11 
     1484951835 
    chicken
    (Gallus gallus)
    Aves ANGPTL76
    Uncharacterized protein
    77(a)
    1 ↔ 1
    21(4169330-4174234)
    lizard
    (Anolis carolinensis)
    Reptilia ANGPTL76
    Uncharacterized protein
    70(a)
    1 ↔ 1
    GL343615.1(184049-203289)
    zebrafish
    (Danio rerio)
    Actinopterygii angptl71 angiopoietin-like 7 68.84(n)
    67.06(a)
      450053  NM_001006073.1  NP_001006073.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG86421 CG8642 56.69(n)
    46.33(a)
      35845  NM_136552.1  NP_610396.1 


    ENSEMBL Gene Tree for ANGPTL7 (if available)
    TreeFam Gene Tree for ANGPTL7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ANGPTL7 gene
    FGL22  ANGPT42  FIBCD12  ANGPTL62  FCN32  ANGPTL22  FCN22  FCN12  
    ANGPT12  ANGPTL12  ANGPT22  MFAP42  
    18/25 SIMAP similar genes for ANGPTL7 using alignment to 2 protein entries:     ANGL7_HUMAN (see all proteins) (see all similar genes):
    ANGPTL1    FCN1    ANGPTL2    FCN2    FCN3    MFAP4
    FGL1    LFIRE1    TNN    TNXB    ANGPT1    ANGPT2
    FGA    ANGPTL4    ANGPT4    ANGPTL6    TNC    TNC variant protein

    ANGPTL7 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    3 SNPs in ANGPTL7 are shown    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0250754
    ----see VAR_0250752 E D mis40--------
    VAR_0250764
    ----see VAR_0250762 R H mis40--------
    VAR_0250774
    ----see VAR_0250772 Q H mis40--------

    HapMap Linkage Disequilibrium report for ANGPTL7 (11249398 - 11256038 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for ANGPTL7: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing ANGPTL7
    DNA2.0 Custom Variant and Variant Library Synthesis for ANGPTL7

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for ANGPTL7:    About MalaCards
    glaucoma    

    1 disease from the University of Copenhagen DISEASES database for ANGPTL7:
    Glaucoma

    ANGPTL7 for disorders           About GeneDecksing


    Export disorders for ANGPTL7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ANGPTL7 gene, integrated from 9 sources (see all 20):
    (articles sorted by number of sources associating them with ANGPTL7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of a new angiopoietin-like factor from the human cornea. (PubMed id 9727400)1, 2, 3, 9 Peek R.... Kijlstra A. (1998)
    2. The angiopoietin-like factor cornea-derived transcript 6 is a putative morphogen for human cornea. (PubMed id 11682471)1, 3, 9 Peek R....Westphal J.R. (2002)
    3. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (2004)
    6. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    7. The human gene for mannan-binding lectin-associated serine protease-2 (MASP-2), the effector component of the lectin route of complement activation, is part of a tightly linked gene cluster on chromosome 1p36.2-3. (PubMed id 11426320)1, 2 Stover C.... Schwaeble W. (2001)
    8. Angiopoietin-like 7 secretion is induced by glaucoma stimuli and its concentration is elevated in glaucomatous aqueous humor. (PubMed id 18421092)1, 9 Kuchtey J....Kuchtey R.W. (2008)
    9. Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method. (PubMed id 21697133)1 Oshikawa M.... Kato S. (2011)
    10. Evidence for a role of angiopoietin-like 7 (ANGPTL7) in extracellular matrix formation of the human trabecular meshwork: implication s for glaucoma. (PubMed id 21199193)1 Comes N....BorrA!s T. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10218 HGNC: 24078 AceView: CDT6 Ensembl:ENSG00000171819 euGenes: HUgn10218
    ECgene: ANGPTL7 H-InvDB: ANGPTL7

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ANGPTL7 Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/angptl7/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ANGPTL7 gene:
    Search GeneIP for patents involving ANGPTL7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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