ANGPTL7 Gene
protein-coding GIFtS : 48
GCID: GC01 P011249
angiopoietin-like 7
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Aliasesfor ANGPTL7 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Angiopoietin-Like 7 1 2 RP4-647M16.22 CDT61 2 3 Angiopoietin-Like Factor (CDT6)2 AngX1 2 Angiopoietin-Related Protein 72 Angiopoietin-Like Protein 72 3 DJ647M16.11 Cornea-Derived Transcript 6 Protein2 3 Angiopoietin-Like Factor3
Export aliases for ANGPTL7 gene to outside databases Previous GC identifers: GC01P011184 GC01P010400
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Summariesfor ANGPTL7 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Gene Wiki entry for ANGPTL7
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Genomic Viewsfor ANGPTL7 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000001.10 NC_018912.1 NT_021937.19 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the ANGPTL7 gene promoter: NRSF form 1 MyoD Olf-1 NRSF form 2 C/EBPalpha Max CHOP-10 FOXJ2 (long isoform) FOXJ2 c-Myc Other transcription factors Search SABiosciences Chromatin IP Primers for ANGPTL7 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ANGPTL7
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 1p36 Ensembl cytogenetic band: 1p36.22 HGNC cytogenetic band: 1p36 ANGPTL7 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 1 GeneLoc Exon Structure
GeneLoc location for GC01P011249: view genomic region
(about GC identifiers )
Start:
11,249,398 bp from pter
End:
11,256,038 bp from pter
Size:
6,641 bases
Orientation:
plus strand
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Proteinsfor ANGPTL7 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: ANGL7_HUMAN, O43827 (See
protein sequence )Recommended Name: Angiopoietin-related protein 7 precursor Size : 346 amino acids; 40018 Da
Subcellular location : Secreted (Probable)
Secondary accessions : B2R9B2 Q4ZGK4Explore the universe of human proteins at neXtProt for ANGPTL7: NX_O43827 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_O43827 ANGPTL7 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_066969.1 ENSEMBL proteins: ENSP00000366015 Human Recombinant Protein Products: Gene Ontology (GO): 1 cellular component term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005576 extracellular region
IEA --
ANGPTL7 for ontologies About GeneDecksing ANGPTL7 Antibody Products: Assay Products for ANGPTL7:
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Protein
Domains / Familiesfor ANGPTL7 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
ANGPTL7 for domains About GeneDecksing 3 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry O43827 ProtoNet protein and cluster: O43827
1 Blocks protein family : IPB002181 Fibrinogen UniProtKB/Swiss-Prot: ANGL7_HUMAN, O43827 Similarity : Contains 1 fibrinogen C-terminal domain
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Functionfor ANGPTL7 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for ANGPTL7 (see all 2 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for ANGPTL7OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: ANGPTL7 (NM_021146 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ANGPTL7 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat ANGPTL7
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANGPTL7
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005102 receptor binding
IEA --
ANGPTL7 for ontologies About GeneDecksing Animal Models: Mouse knock-out Angptl7 tm1Lex for ANGPTL7 1 MGI phenotypic allele for Angptl7 (no phenotypes)
ANGPTL7 for phenotypes About GeneDecksing
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Pathways & Interactionsfor ANGPTL7 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ANGPTL7 Gene Ontology (GO): 2 biological process terms (GO ID links to tree view) : About this table
ANGPTL7 for ontologies About GeneDecksing
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Drugs & Compoundsfor ANGPTL7 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for ANGPTL7 Search CenterWatch for drugs/clinical trials and news about ANGPTL7 / ANGL7
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Transcriptsfor ANGPTL7 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for ANGPTL7 gene: NM_021146.2 Unigene Cluster for ANGPTL7:
Angiopoietin-like 7 Hs.146559 [show with all ESTs ] Unigene Representative Sequence: NM_021146 2 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000376819 (uc001ase.3 ) ENST00000476934 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for ANGPTL7 (see all 2 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for ANGPTL7OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: ANGPTL7 (NM_021146 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ANGPTL7 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat ANGPTL7
Additional cDNA sequence: AB593026.1 AB593027.1 AK313716.1 AY358301.1 BC001881.1 BT009802.1 Y16132.1
2 DOTS entries : DT.40272468 DT.101971229
24/81 AceView cDNA sequences (see all 81 ):
CD679316 CD677183 BE276843 AU279785 CD679305 CA407625 AI278780 BT009802 BE276592 CD517580 CD676529 CD518252 BF025871 CD678923 CD678813 BM720771 BX483048 BQ898121 CD679061 BE389513 BQ722925 BE390279 CA413386 BC001881 GeneLoc Exon Structure 2 Alternative Splicing Database (ASD) splice patterns (SP) for ANGPTL7 About this scheme ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b SP1 :                 SP2 :         -        
ECgene alternative splicing isoforms for ANGPTL7
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Expression for ANGPTL7 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section ANGPTL7 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: GATGCCGGCA
About this image ANGPTL7 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table See ANGPTL7 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for ANGPTL7 SOURCE GeneReport for Unigene cluster: Hs.146559 UniProtKB/Swiss-Prot: ANGL7_HUMAN, O43827 Tissue specificity : Highly and specifically expressed in the cornea where is confined to the stromal layer SABiosciences Custom PCR Arrays for ANGPTL7 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for ANGPTL7Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat ANGPTL7 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat ANGPTL7 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat ANGPTL7 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANGPTL7
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Orthologsfor ANGPTL7 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of animals.
Orthologs for ANGPTL7 gene from 4/13 species (see all 13 ) About this table
ENSEMBL Gene Tree for ANGPTL7 (if available)TreeFam Gene Tree for ANGPTL7 (if available)
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Paralogsfor ANGPTL7 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for ANGPTL7 gene FGL2 2 ANGPT4 2 FGA 2 FGG 2 ANGPTL6 2 ANGPTL2 2 ANGPTL4 2 ANGPT1 2 ANGPTL3 2 ANGPTL1 2 FGB 2 ANGPT2 2 FGL1 2 18/25 SIMAP similar genes for ANGPTL7 using alignment to 2 protein entries: ANGL7_HUMAN (see all proteins )
(see all similar genes ):ANGPTL1 FCN1 ANGPTL2 FCN2 FCN3 MFAP4 FGL1 LFIRE1 TNN TNXB ANGPT1 ANGPT2 FGA ANGPTL4 ANGPT4 ANGPTL6 TNC TNC variant protein
ANGPTL7 for paralogs About GeneDecksing
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Genomic Variantsfor ANGPTL7 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing ANGPTL7
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Disorders
/ Diseasesfor ANGPTL7 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
ANGPTL7 for disorders About GeneDecksing 1 disease for ANGPTL7 : About MalaCards glaucoma 1 disease from the University of Copenhagen DISEASES database for ANGPTL7 :Glaucoma Export disorders for ANGPTL7 gene to outside databases
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Publicationsfor ANGPTL7 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for ANGPTL7 gene, integrated from 9 sources (see all 18 ): (articles sorted by number of sources associating them with ANGPTL7) Utopia : connect your pdf to the dynamic world of online information
Molecular cloning of a new angiopoietin-like factor from the human cornea. (PubMed id 9727400) 1 , 2 , 3, 9 Peek R.... Kijlstra A. (1998) The angiopoietin-like factor cornea-derived transcript 6 is a putative morphogen for human cornea. (PubMed id 11682471) 1 , 3, 9 Peek R....Westphal J.R. (2002) The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414) 1 , 2 Gregory S.G.... Bentley D.R. (2006) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161) 1 , 2 Zhang Z. and Henzel W.J. (2004) The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309) 1 , 2 Clark H.F.... Gray A.M. (2003) The human gene for mannan-binding lectin-associated serine protease-2 (MASP-2), the effector component of the lectin route of complement activation, is part of a tightly linked gene cluster on chromosome 1p36.2-3. (PubMed id 11426320) 1 , 2 Stover C.... Schwaeble W. (2001) Angiopoietin-like 7 secretion is induced by glaucoma stimuli and its concentration is elevated in glaucomatous aqueous humor. (PubMed id 18421092) 1 , 9 Kuchtey J....Kuchtey R.W. (2008) Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method. (PubMed id 21697133) 1 Oshikawa M.... Kato S. (2011) Evidence for a role of angiopoietin-like 7 (ANGPTL7) in extracellular matrix formation of the human trabecular meshwork: implication s for glaucoma. (PubMed id 21199193) 1 Comes N....BorrA!s T. (2011)
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External Searches for ANGPTL7 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing ANGPTL7 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing ANGPTL7 gene
(According to HUGE )
About This Section --
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Specialized Databases showing ANGPTL7 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for ANGPTL7 Pharmacogenomics, SNPs, Pathways NIEHS-SNPs http://egp.gs.washington.edu/data/angptl7/
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About This Section Patent Information for ANGPTL7 gene: Search GeneIP for patents involving ANGPTL7 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor ANGPTL7 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for ANGPTL7 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for ANGPTL7 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for ANGPTL7 OriGene Protein Over-expression Lysate for ANGPTL7 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for ANGPTL7 Browse 3'-UTR reporter clones for miRNA target validation OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for ANGPTL7 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for ANGPTL7 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs OriGene Purified Protein for ANGPTL7 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for ANGPTL7 OriGene Custom Protein Services for ANGPTL7 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ANGPTL7 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing ANGPTL7 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ANGPTL7 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat ANGPTL7 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat ANGPTL7 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat ANGPTL7
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ANGPTL7 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANGPTL7
ThermoFisher Antibodies for ANGPTL7
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat ANGPTL7
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