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Aliases for ANGPTL7 Gene

Aliases for ANGPTL7 Gene

  • Angiopoietin Like 7 2 3 5
  • Cornea-Derived Transcript 6 Protein 3 4
  • Angiopoietin-Like Protein 7 3 4
  • Angiopoietin-Like 7 2 3
  • CDT6 3 4
  • Angiopoietin-Like Factor (CDT6) 3
  • Angiopoietin-Like Factor 4
  • DJ647M16.1 3
  • AngX 3

External Ids for ANGPTL7 Gene

Previous GeneCards Identifiers for ANGPTL7 Gene

  • GC01P011184
  • GC01P011249
  • GC01P010400

Summaries for ANGPTL7 Gene

GeneCards Summary for ANGPTL7 Gene

ANGPTL7 (Angiopoietin Like 7) is a Protein Coding gene. An important paralog of this gene is FGB.

Gene Wiki entry for ANGPTL7 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANGPTL7 Gene

Genomics for ANGPTL7 Gene

Regulatory Elements for ANGPTL7 Gene

Enhancers for ANGPTL7 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ANGPTL7 on UCSC Golden Path with GeneCards custom track

Genomic Location for ANGPTL7 Gene

11,189,289 bp from pter
11,195,981 bp from pter
6,693 bases
Plus strand

Genomic View for ANGPTL7 Gene

Genes around ANGPTL7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANGPTL7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANGPTL7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANGPTL7 Gene

Proteins for ANGPTL7 Gene

  • Protein details for ANGPTL7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Angiopoietin-related protein 7
    Protein Accession:
    Secondary Accessions:
    • B2R9B2
    • F1T0A6
    • Q4ZGK4

    Protein attributes for ANGPTL7 Gene

    346 amino acids
    Molecular mass:
    40018 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ANGPTL7 Gene

Proteomics data for ANGPTL7 Gene at MOPED

Post-translational modifications for ANGPTL7 Gene

  • Glycosylation at Asn 58, Asn 253, and Asn 267
  • Modification sites at PhosphoSitePlus

Other Protein References for ANGPTL7 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for ANGPTL7 (Angiopoietin-like Protein 7/ANGPTL7)
  • Santa Cruz Biotechnology (SCBT) Antibodies for ANGPTL7

No data available for DME Specific Peptides for ANGPTL7 Gene

Domains & Families for ANGPTL7 Gene

Gene Families for ANGPTL7 Gene

Suggested Antigen Peptide Sequences for ANGPTL7 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 fibrinogen C-terminal domain.
  • Contains 1 fibrinogen C-terminal domain.
genes like me logo Genes that share domains with ANGPTL7: view

Function for ANGPTL7 Gene

Phenotypes for ANGPTL7 Gene

genes like me logo Genes that share phenotypes with ANGPTL7: view

Animal Model Products

  • Taconic Biosciences Mouse Models for ANGPTL7

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ANGPTL7 Gene

Localization for ANGPTL7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ANGPTL7 Gene


Subcellular locations from

Jensen Localization Image for ANGPTL7 Gene COMPARTMENTS Subcellular localization image for ANGPTL7 gene
Compartment Confidence
extracellular 5

No data available for Gene Ontology (GO) - Cellular Components for ANGPTL7 Gene

Pathways & Interactions for ANGPTL7 Gene

SuperPathways for ANGPTL7 Gene

No Data Available

Interacting Proteins for ANGPTL7 Gene

Gene Ontology (GO) - Biological Process for ANGPTL7 Gene


No data available for Pathways by source and SIGNOR curated interactions for ANGPTL7 Gene

Drugs & Compounds for ANGPTL7 Gene

No Compound Related Data Available

Transcripts for ANGPTL7 Gene

mRNA/cDNA for ANGPTL7 Gene

Unigene Clusters for ANGPTL7 Gene

Angiopoietin-like 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ANGPTL7 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b
SP2: -

Relevant External Links for ANGPTL7 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ANGPTL7 Gene

mRNA expression in normal human tissues for ANGPTL7 Gene

mRNA differential expression in normal tissues according to GTEx for ANGPTL7 Gene

This gene is overexpressed in Nerve - Tibial (x38.3).

Protein differential expression in normal tissues from HIPED for ANGPTL7 Gene

This gene is overexpressed in Vitreous humor (68.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ANGPTL7 Gene

SOURCE GeneReport for Unigene cluster for ANGPTL7 Gene Hs.146559

mRNA Expression by UniProt/SwissProt for ANGPTL7 Gene

Tissue specificity: Highly and specifically expressed in the cornea where is confined to the stromal layer.
genes like me logo Genes that share expression patterns with ANGPTL7: view

Protein tissue co-expression partners for ANGPTL7 Gene

Primer Products

Orthologs for ANGPTL7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ANGPTL7 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ANGPTL7 35
  • 90.7 (n)
  • 90.7 (a)
  • 91 (a)
(Canis familiaris)
Mammalia ANGPTL7 35
  • 90.31 (n)
  • 92.15 (a)
  • 92 (a)
(Mus musculus)
Mammalia Angptl7 35
  • 88.39 (n)
  • 88.89 (a)
Angptl7 16
Angptl7 36
  • 88 (a)
(Pan troglodytes)
Mammalia ANGPTL7 35
  • 99.42 (n)
  • 99.42 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia LOC102552055 35
  • 87.92 (n)
  • 89.22 (a)
(Monodelphis domestica)
Mammalia ANGPTL7 36
  • 78 (a)
(Ornithorhynchus anatinus)
Mammalia ANGPTL7 36
  • 80 (a)
(Gallus gallus)
Aves ANGPTL7 35
  • 75.24 (n)
  • 77.46 (a)
  • 77 (a)
(Anolis carolinensis)
Reptilia ANGPTL7 36
  • 70 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia angptl7 35
  • 71.74 (n)
  • 74.93 (a)
(Danio rerio)
Actinopterygii angptl7 35
  • 68.84 (n)
  • 67.06 (a)
angptl7 36
  • 66 (a)
Species with no ortholog for ANGPTL7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ANGPTL7 Gene

Gene Tree for ANGPTL7 (if available)
Gene Tree for ANGPTL7 (if available)

Paralogs for ANGPTL7 Gene

Paralogs for ANGPTL7 Gene

genes like me logo Genes that share paralogs with ANGPTL7: view

Variants for ANGPTL7 Gene

Sequence variations from dbSNP and Humsavar for ANGPTL7 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
VAR_025075 -
VAR_025076 -
VAR_025077 -

Variation tolerance for ANGPTL7 Gene

Residual Variation Intolerance Score: 57.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.28; 62.68% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for ANGPTL7 Gene

Disorders for ANGPTL7 Gene

Relevant External Links for ANGPTL7

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ANGPTL7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANGPTL7 Gene

Publications for ANGPTL7 Gene

  1. Molecular cloning of a new angiopoietin-like factor from the human cornea. (PMID: 9727400) Peek R. … Kijlstra A. (Invest. Ophthalmol. Vis. Sci. 1998) 2 3 4 23 67
  2. The angiopoietin-like factor cornea-derived transcript 6 is a putative morphogen for human cornea. (PMID: 11682471) Peek R. … Westphal J.R. (J. Biol. Chem. 2002) 2 3 23
  3. Angiopoietin-like 7 secretion is induced by glaucoma stimuli and its concentration is elevated in glaucomatous aqueous humor. (PMID: 18421092) Kuchtey J. … Kuchtey R.W. (Invest. Ophthalmol. Vis. Sci. 2008) 3 23
  4. Angiopoietin-like 7 is an anti-angiogenic protein required to prevent vascularization of the cornea. (PMID: 25622036) Toyono T. … Amano S. (PLoS ONE 2015) 3
  5. Cd11b(+) myeloid cells support hepatic metastasis through down-regulation of angiopoietin-like 7 in cancer cells. (PMID: 25854806) Lim S.Y. … Muschel R.J. (Hepatology 2015) 3

Products for ANGPTL7 Gene

Sources for ANGPTL7 Gene