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Aliases for ANGPTL6 Gene

Aliases for ANGPTL6 Gene

  • Angiopoietin-Like 6 2 3
  • Angiopoietin-Related Protein 5 2 3 4
  • AGF 3 4 6
  • Angiopoietin-Related Growth Factor 3 4
  • Angiopoietin-Like Protein 6 3 4
  • Arp5 3 4
  • Angiopoietin-Related Protein 6 3

External Ids for ANGPTL6 Gene

Summaries for ANGPTL6 Gene

GeneCards Summary for ANGPTL6 Gene

ANGPTL6 (Angiopoietin-Like 6) is a Protein Coding gene. Diseases associated with ANGPTL6 include enterobiasis and gnathomiasis. Among its related pathways are NF-KappaB Family Pathway and NF-KappaB Family Pathway. An important paralog of this gene is FIBCD1.

UniProtKB/Swiss-Prot for ANGPTL6 Gene

  • May play a role in the wound healing process. May promote epidermal proliferation, remodeling and regeneration. May promote the chemotactic activity of endothelial cells and induce neovascularization. May counteract high-fat diet-induced obesity and related insulin resistance through increased energy expenditure

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANGPTL6 Gene

Genomics for ANGPTL6 Gene

Genomic Location for ANGPTL6 Gene

Start:
10,092,337 bp from pter
End:
10,102,888 bp from pter
Size:
10,552 bases
Orientation:
Minus strand

Genomic View for ANGPTL6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ANGPTL6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANGPTL6 Gene

Regulatory Elements for ANGPTL6 Gene

Proteins for ANGPTL6 Gene

  • Protein details for ANGPTL6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NI99-ANGL6_HUMAN
    Recommended name:
    Angiopoietin-related protein 6
    Protein Accession:
    Q8NI99
    Secondary Accessions:
    • A5PKV7
    • Q9BZZ0

    Protein attributes for ANGPTL6 Gene

    Size:
    470 amino acids
    Molecular mass:
    51694 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ANGPTL6 Gene

Proteomics data for ANGPTL6 Gene at MOPED

Post-translational modifications for ANGPTL6 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn58 and Asn145

Other Protein References for ANGPTL6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ANGPTL6 Gene

Domains for ANGPTL6 Gene

Gene Families for ANGPTL6 Gene

HGNC:
  • FIBC :Fibrinogen C domain containing

UniProtKB/Swiss-Prot:

ANGL6_HUMAN
Domain:
  • Contains 1 fibrinogen C-terminal domain.:
    • Q8NI99
genes like me logo Genes that share domains with ANGPTL6: view

Function for ANGPTL6 Gene

Molecular function for ANGPTL6 Gene

UniProtKB/Swiss-Prot Function: May play a role in the wound healing process. May promote epidermal proliferation, remodeling and regeneration. May promote the chemotactic activity of endothelial cells and induce neovascularization. May counteract high-fat diet-induced obesity and related insulin resistance through increased energy expenditure
genes like me logo Genes that share phenotypes with ANGPTL6: view

Animal Models for ANGPTL6 Gene

MGI Knock Outs for ANGPTL6:

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , miRNA , Transcription Factor Targeting and HOMER Transcription for ANGPTL6 Gene

Localization for ANGPTL6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ANGPTL6 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ANGPTL6 Gene COMPARTMENTS Subcellular localization image for ANGPTL6 gene
Compartment Confidence
extracellular 4
cytosol 2
mitochondrion 2
chloroplast 1
lysosome 1

Gene Ontology (GO) - Cellular Components for ANGPTL6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030141 secretory granule IEA --
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with ANGPTL6: view

Pathways for ANGPTL6 Gene

genes like me logo Genes that share pathways with ANGPTL6: view

Pathways by source for ANGPTL6 Gene

Interacting Proteins for ANGPTL6 Gene

Gene Ontology (GO) - Biological Process for ANGPTL6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IEA --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with ANGPTL6: view

Compounds for ANGPTL6 Gene

(2) Novoseek inferred chemical compound relationships for ANGPTL6 Gene

Compound -log(P) Hits PubMed IDs
lipid 28.3 3
glucose 4.72 4
genes like me logo Genes that share compounds with ANGPTL6: view

Transcripts for ANGPTL6 Gene

Unigene Clusters for ANGPTL6 Gene

Angiopoietin-like 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ANGPTL6 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4
SP1: -
SP2:
SP3:

Relevant External Links for ANGPTL6 Gene

GeneLoc Exon Structure for
ANGPTL6
ECgene alternative splicing isoforms for
ANGPTL6

Expression for ANGPTL6 Gene

mRNA expression in normal human tissues for ANGPTL6 Gene

mRNA differential expression in normal tissues according to GTEx for ANGPTL6 Gene

This gene is overexpressed in Liver (15.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ANGPTL6 Gene

SOURCE GeneReport for Unigene cluster for ANGPTL6 Gene Hs.712850

genes like me logo Genes that share expressions with ANGPTL6: view

Orthologs for ANGPTL6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ANGPTL6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ANGPTL6 36
  • 98.3 (n)
  • 98.09 (a)
ANGPTL6 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ANGPTL6 36
  • 87.5 (n)
  • 90.5 (a)
ANGPTL6 37
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ANGPTL6 36
  • 87.39 (n)
  • 90.04 (a)
ANGPTL6 37
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Angptl6 36
  • 76.85 (n)
  • 72.62 (a)
Angptl6 16
Angptl6 37
  • 76 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ANGPTL6 37
  • 62 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Angptl6 36
  • 76.32 (n)
  • 72.4 (a)
chicken
(Gallus gallus)
Aves -- 37
  • 36 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia ANGPTL6 37
  • 49 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.12563 36
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.13338 36
zebrafish
(Danio rerio)
Actinopterygii angptl6 37
  • 43 (a)
OneToOne
Dr.24020 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 34 (a)
OneToMany
Species with no ortholog for ANGPTL6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ANGPTL6 Gene

ENSEMBL:
Gene Tree for ANGPTL6 (if available)
TreeFam:
Gene Tree for ANGPTL6 (if available)

Paralogs for ANGPTL6 Gene

Selected SIMAP similar genes for ANGPTL6 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ANGPTL6: view

Variants for ANGPTL6 Gene

Sequence variations from dbSNP and Humsavar for ANGPTL6 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs2336689 -- 10,097,439(+) tttct(A/G)ggcac intron-variant
rs4804484 -- 10,103,865(+) CAAGG(C/T)GGGCA upstream-variant-2KB
rs4804485 -- 10,103,993(+) GAGGC(C/T)GAGGC upstream-variant-2KB
rs6511431 -- 10,097,194(+) tgagc(C/T)tagga intron-variant
rs6511432 -- 10,097,332(+) agctg(C/T)gatca intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ANGPTL6 Gene

Variant ID Type Subtype PubMed ID
nsv458355 CNV Loss 19166990
nsv2414 CNV Insertion 18451855
nsv833743 CNV Loss 17160897
esv29826 CNV Loss 19812545
esv2675304 CNV Deletion 23128226

Relevant External Links for ANGPTL6 Gene

HapMap Linkage Disequilibrium report
ANGPTL6

Disorders for ANGPTL6 Gene

(2) MalaCards Diseases for ANGPTL6 Gene

Search for ANGPTL6 Gene in MalaCards »

(3) University of Copenhagen DISEASES for ANGPTL6 Gene

(1) Novoseek inferred disease relationships for ANGPTL6 Gene

Disease -log(P) Hits PubMed IDs
inflammation 6.77 2

Relevant External Links for ANGPTL6

Genetic Association Database (GAD)
ANGPTL6
Human Genome Epidemiology (HuGE) Navigator
ANGPTL6
genes like me logo Genes that share disorders with ANGPTL6: view

No data available for UniProtKB/Swiss-Prot for ANGPTL6 Gene

Publications for ANGPTL6 Gene

  1. Angiopoietin-related growth factor (AGF) promotes epidermal proliferation, remodeling, and regeneration. (PMID: 12871997) Oike Y. … Suda T. (Proc. Natl. Acad. Sci. U.S.A. 2003) 2 3 4
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  3. Angiopoietin-related growth factor (AGF) supports adhesion, spreading, and migration of keratinocytes, fibroblasts, and endothelial cells through interaction with RGD-binding integrins. (PMID: 16806062) Zhang Y. … Gong Y. (Biochem. Biophys. Res. Commun. 2006) 3 23
  4. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PMID: 16335952) Liu T. … Smith R.D. (J. Proteome Res. 2005) 3 4
  5. A genome-wide association study identifies protein quantitative trait loci (pQTLs). (PMID: 18464913) Melzer D. … Ferrucci L. (PLoS Genet. 2008) 3 49

Products for ANGPTL6 Gene

Sources for ANGPTL6 Gene

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