Aliases for ANGPTL6 Gene
Aliases for ANGPTL6 Gene
External Ids for ANGPTL6 Gene
- HGNC: 23140
- Entrez Gene: 83854
- Ensembl: ENSG00000130812
- OMIM: 609336
- UniProtKB: Q8NI99
Previous GeneCards Identifiers for ANGPTL6 Gene
- GC19M010048
- GC19M010064
- GC19M010203
- GC19M009783
Summaries for ANGPTL6 Gene
GeneCards Summary for ANGPTL6 Gene
ANGPTL6 (Angiopoietin Like 6) is a Protein Coding gene. Diseases associated with ANGPTL6 include Gnathomiasis and Enterobiasis. Among its related pathways are GPCR Pathway and Phospholipase-C Pathway. An important paralog of this gene is ANGPTL2.
UniProtKB/Swiss-Prot for ANGPTL6 Gene
-
May play a role in the wound healing process. May promote epidermal proliferation, remodeling and regeneration. May promote the chemotactic activity of endothelial cells and induce neovascularization. May counteract high-fat diet-induced obesity and related insulin resistance through increased energy expenditure.
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANGPTL6 Gene
Genomics for ANGPTL6 Gene
Regulatory Elements for ANGPTL6 Gene
Regulatory Element Products
Genomic Location for ANGPTL6 Gene
- Chromosome:
- 19
- Start:
- 10,092,337 bp from pter
- End:
- 10,106,209 bp from pter
- Size:
- 13,873 bases
- Orientation:
- Minus strand
Genomic View for ANGPTL6 Gene
- Cytogenetic band:
-
- 19p13.2 by Ensembl
- 19p13.2 by Entrez Gene
- 19p13.2 by HGNC
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ANGPTL6 Gene
Proteins for ANGPTL6 Gene
-
Protein details for ANGPTL6 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8NI99-ANGL6_HUMAN
- Recommended name:
- Angiopoietin-related protein 6
- Protein Accession:
- Q8NI99
- A5PKV7
- Q9BZZ0
Protein attributes for ANGPTL6 Gene
- Size:
- 470 amino acids
- Molecular mass:
- 51694 Da
- Quaternary structure:
- No Data Available
Protein Expression for ANGPTL6 Gene
Post-translational modifications for ANGPTL6 Gene
Other Protein References for ANGPTL6 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for ANGPTL6 (Angiopoietin-like Protein 6/ANGPTL6)
- Novus Biologicals Antibodies for ANGPTL6
-
Cloud-Clone Corp. Antibodies for ANGPTL6
- Invitrogen Antibodies for ANGPTL6
- antibodies-online Antibodies for ANGPTL6: See all 72
- GeneTex ANGPTL6 antibody for ANGPTL6
Protein Products
- R&D Systems Proteins and Enzymes for ANGPTL6 (Angiopoietin-like Protein 6/ANGPTL6)
-
OriGene Purified Proteins for ANGPTL6
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- ProSpec Recombinant Proteins for ANGPTL6
-
Cloud-Clone Corp. Proteins for ANGPTL6
- antibodies-online Proteins for ANGPTL6: See all 10
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-
ProSci Proteins for ANGPTL6
Assay Products
- R&D Systems Luminex Assays, ELISAs, and other biochemical assays for ANGPTL6 (Angiopoietin-like Protein 6/ANGPTL6)
-
Cloud-Clone Corp Assay Kits for ANGPTL6
- antibodies-online Kits for ANGPTL6: See all 29
No data available for DME Specific Peptides for ANGPTL6 Gene
Domains & Families for ANGPTL6 Gene
Gene Families for ANGPTL6 Gene
Protein Domains for ANGPTL6 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for ANGPTL6 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for ANGPTL6 Gene
Function for ANGPTL6 Gene
Molecular function for ANGPTL6 Gene
- UniProtKB/Swiss-Prot Function:
- May play a role in the wound healing process. May promote epidermal proliferation, remodeling and regeneration. May promote the chemotactic activity of endothelial cells and induce neovascularization. May counteract high-fat diet-induced obesity and related insulin resistance through increased energy expenditure.
Phenotypes for ANGPTL6 Gene
- MGI mutant phenotypes for ANGPTL6:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for ANGPTL6:
-
- Increased viability
- Increased vaccinia virus (VACV) infection
- Decreased hepcidin::fluc mRNA expression
- Decreased NF-kappaB reporter expression
- Increased transferrin (TF) endocytosis
- Decreased POU5F1-GFP protein expression
- Decreased IL-8 secretion
- Decreased viability of wild-type and TP53 knockout cells
- Increased Sindbis virus (SINV) infection
Animal Models for ANGPTL6 Gene
- MGI Knock Outs for ANGPTL6:
-
- Angptl6 tm1Yo
Animal Model Products
-
Taconic Biosciences Mouse Models for ANGPTL6
- Cyagen custom Knockout/knockin (KOKI) mouse models for ANGPTL6
-
-
ViGene Biosciences lentiviral particle packaged cDNA for ANGPTL6 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for ANGPTL6 gene
- Search ViGene Biosciences for ANGPTL6
CRISPR Products
-
OriGene CRISPR knockouts for ANGPTL6
-
Santa Cruz Biotechnology (SCBT) CRISPR for ANGPTL6
- GenScript: Design CRISPR guide RNA sequences for ANGPTL6
miRNA Products
- Search ViGene Biosciences for ANGPTL6
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for ANGPTL6
- Browse OriGene Inhibitory RNA Products For ANGPTL6
-
ViGene Biosciences ready-to-package AAV shRNAs for ANGPTL6 gene
Clone Products
-
OriGene ORF clones in human for ANGPTL6
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- VectorBuilder custom plasmid, inducible vectors for ANGPTL6
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ANGPTL6
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for ANGPTL6
-
ViGene Biosciences adenoviral particle packaged cDNA for ANGPTL6 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for ANGPTL6 gene
-
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Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for ANGPTL6 Gene
Localization for ANGPTL6 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ANGPTL6 Gene
- Secreted.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | IEA | -- |
| GO:0030141 | secretory granule | IEA | -- |
| GO:0070062 | extracellular exosome | IDA | 23533145 |
Pathways & Interactions for ANGPTL6 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Apoptotic Pathways in Synovial Fibroblasts |
.74
.66
|
.65
.61
.60
.57
|
| 2 | GPCR Pathway |
.73
.62
|
.55
|
| 3 | ERK Signaling |
.61
.58
|
.49
|
| 4 | Nanog in Mammalian ESC Pluripotency |
.61
|
.48
|
| 5 | CREB Pathway |
.68
.68
|
|
Pathways by source for ANGPTL6 Gene
Interacting Proteins for ANGPTL6 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001525 | angiogenesis | IEA | -- |
| GO:0007275 | multicellular organism development | IEA | -- |
| GO:0030154 | cell differentiation | IEA | -- |
No data available for SIGNOR curated interactions for ANGPTL6 Gene
Transcripts for ANGPTL6 Gene
mRNA/cDNA for ANGPTL6 Gene
- (8) REFSEQ mRNAs :
- (4) Additional mRNA sequences :
- (31) Selected AceView cDNA sequences:
- (4) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for ANGPTL6
-
Santa Cruz Biotechnology (SCBT) CRISPR for ANGPTL6
- GenScript: Design CRISPR guide RNA sequences for ANGPTL6
miRNA Products
- Search ViGene Biosciences for ANGPTL6
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for ANGPTL6
- Browse OriGene Inhibitory RNA Products For ANGPTL6
-
ViGene Biosciences ready-to-package AAV shRNAs for ANGPTL6 gene
Clone Products
-
OriGene ORF clones in human for ANGPTL6
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for ANGPTL6
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for ANGPTL6
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ANGPTL6
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 |
|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||
| SP2: | |||||||||
| SP3: |
Expression for ANGPTL6 Gene
mRNA differential expression in normal tissues according to GTEx for ANGPTL6 Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ANGPTL6 Gene
NURSA nuclear receptor signaling pathways regulating expression of ANGPTL6 Gene:
ANGPTL6SOURCE GeneReport for Unigene cluster for ANGPTL6 Gene:
Hs.712850Evidence on tissue expression from TISSUES for ANGPTL6 Gene
- Liver(4.3)
- Bone marrow(4)
Primer Products
-
OriGene qPCR primer pairs for ANGPTL6
-
OriGene qPCR primer pairs and template standards for ANGPTL6
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ANGPTL6 Gene
Orthologs for ANGPTL6 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ANGPTL6 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | ANGPTL6 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | ANGPTL6 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Angptl6 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Angptl6 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | ANGPTL6 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | -- 35 |
|
ManyToMany | |
| lizard (Anolis carolinensis) |
Reptilia | ANGPTL6 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | Str.13338 34 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.12563 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | angptl6 35 |
|
OneToOne | |
| Dr.24020 34 |
|
||||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
OneToMany |
- Species where no ortholog for ANGPTL6 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for ANGPTL6 Gene
Paralogs for ANGPTL6 Gene
(10) SIMAP similar genes for ANGPTL6 Gene using alignment to 2 proteins:
Variants for ANGPTL6 Gene
| SNP ID | Clin | Chr 19 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1551570 | other | 10,107,354(+) | TCCGA(C/T)TGACT | intron-variant, upstream-variant-2KB | |
| rs1000134422 | -- | 10,094,621(+) | CCTTA(A/G)AAGTT | intron-variant | |
| rs1000143334 | -- | 10,100,444(+) | TTGCC(C/T)AGGCT | intron-variant | |
| rs1000270421 | -- | 10,094,442(+) | CGCCC(A/G)GCCAA | intron-variant | |
| rs1000522015 | -- | 10,095,972(+) | AGGCT(A/G)CGAGG | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv6266n54 | CNV | loss | 21841781 |
| esv2675304 | CNV | deletion | 23128226 |
| esv29826 | CNV | loss | 19812545 |
| esv3556016 | CNV | deletion | 23714750 |
| esv3643648 | CNV | loss | 21293372 |
| nsv2414 | CNV | insertion | 18451855 |
| nsv458355 | CNV | loss | 19166990 |
| nsv578606 | CNV | loss | 21841781 |
| nsv578610 | CNV | loss | 21841781 |
| nsv833743 | CNV | loss | 17160897 |
Relevant External Links for ANGPTL6 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- ANGPTL6
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANGPTL6 Gene
Disorders for ANGPTL6 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| gnathomiasis |
|
|
| enterobiasis |
|
|
| obesity |
|
|
Relevant External Links for ANGPTL6
No data available for UniProtKB/Swiss-Prot and Genatlas for ANGPTL6 Gene
Publications for ANGPTL6 Gene
- Angiopoietin-related growth factor (AGF) promotes epidermal proliferation, remodeling, and regeneration. (PMID: 12871997) Oike Y. … Suda T. (Proc. Natl. Acad. Sci. U.S.A. 2003) 2 3 4 64
- Association between angiopoietin-like 6 (ANGPTL6) gene polymorphisms and metabolic syndrome-related phenotypes in the French MONICA Study. (PMID: 19447061) Legry V. … Meirhaeghe A. (Diabetes Metab. 2009) 3 46 64
- A genome-wide association study identifies protein quantitative trait loci (pQTLs). (PMID: 18464913) Melzer D. … Ferrucci L. (PLoS Genet. 2008) 3 46 64
- Angiopoietin-related growth factor (AGF) supports adhesion, spreading, and migration of keratinocytes, fibroblasts, and endothelial cells through interaction with RGD-binding integrins. (PMID: 16806062) Zhang Y. … Gong Y. (Biochem. Biophys. Res. Commun. 2006) 3 22 64
- Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PMID: 16335952) Liu T. … Smith R.D. (J. Proteome Res. 2005) 3 4 64
Products for ANGPTL6 Gene
- R&D Systems Antibodies for ANGPTL6 (Angiopoietin-like Protein 6/ANGPTL6)
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- Taconic Biosciences Mouse Models for ANGPTL6
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- antibodies-online Antibodies for ANGPTL6: See all 72
- antibodies-online Kits for ANGPTL6: See all 29
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- ViGene Biosciences adenoviral particle packaged cDNA for ANGPTL6 gene
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- ProSci Proteins for ANGPTL6
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- Cyagen custom Knockout/knockin (KOKI) mouse models for ANGPTL6
- VectorBuilder custom plasmid, inducible vectors for ANGPTL6
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ANGPTL6
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for ANGPTL6 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
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- (115) ProteomicsDB
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- (128) Genetics Home Reference
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- (140) FANTOM5
- (141) ENCODE
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- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer




