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Aliases for ANGPTL6 Gene

Aliases for ANGPTL6 Gene

  • Angiopoietin Like 6 2 3 5
  • Angiopoietin-Related Protein 5 2 3 4
  • Angiopoietin-Related Growth Factor 3 4
  • Angiopoietin-Like Protein 6 3 4
  • Arp5 3 4
  • AGF 3 4
  • Angiopoietin-Related Protein 6 3
  • Angiopoietin-Like 6 2

External Ids for ANGPTL6 Gene

Previous GeneCards Identifiers for ANGPTL6 Gene

  • GC19M010048
  • GC19M010064
  • GC19M010203
  • GC19M009783

Summaries for ANGPTL6 Gene

GeneCards Summary for ANGPTL6 Gene

ANGPTL6 (Angiopoietin Like 6) is a Protein Coding gene. Diseases associated with ANGPTL6 include Gnathomiasis and Enterobiasis. Among its related pathways are Activation of cAMP-Dependent PKA and GPCR Pathway. An important paralog of this gene is ANGPTL2.

UniProtKB/Swiss-Prot for ANGPTL6 Gene

  • May play a role in the wound healing process. May promote epidermal proliferation, remodeling and regeneration. May promote the chemotactic activity of endothelial cells and induce neovascularization. May counteract high-fat diet-induced obesity and related insulin resistance through increased energy expenditure.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANGPTL6 Gene

Genomics for ANGPTL6 Gene

Regulatory Elements for ANGPTL6 Gene

Enhancers for ANGPTL6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F010197 0.8 Ensembl ENCODE 17.1 -93.5 -93499 4.2 HDGF KLF1 ZMYM3 ZNF384 ZNF316 NFE2 MAFK SCRT1 ZNF362 L3MBTL2 C19orf66 ANGPTL6 S1PR2 MRPL4 ICAM1 EIF3G P2RY11 SNORD105B PPAN PPAN-P2RY11
GH19F010141 1.3 Ensembl ENCODE 17 -36.9 -36899 2.2 CREB3L1 NFRKB ZNF48 ZNF335 ZNF121 ZNF766 PAF1 SMARCA5 MIER1 ZBTB11 C19orf66 ANGPTL6 EIF3G SNORD105B P2RY11 PPAN PPAN-P2RY11 SNORD105 RDH8 COL5A3
GH19F010138 0.8 ENCODE 12.4 -32.4 -32361 1.0 HIC1 POLR2A SNORD105B P2RY11 ANGPTL6 PPAN PPAN-P2RY11 SNORD105 EIF3G GC19M010177
GH19F010071 0.6 ENCODE 11.9 +34.9 34910 0.2 ATF3 GABPB1 ZBTB33 RAD21 NR2F2 YY1 ANGPTL6 PPAN PPAN-P2RY11 RDH8 COL5A3 EIF3G OLFM2 C19orf66 MIR5589
GH19F010192 0.7 FANTOM5 ENCODE 11.7 -88.1 -88100 3.4 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 FBXL12 ZNF561 EIF3G UBE2L4 ENSG00000267510 LOC100128428 MIR1181 PPAN PPAN-P2RY11 ANGPTL6
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ANGPTL6 on UCSC Golden Path with GeneCards custom track

Promoters for ANGPTL6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000343217 -291 1401 HDGF PKNOX1 CREB3L1 MLX WRNIP1 ZFP64 ARID4B SIN3A DMAP1 ZNF2

Genomic Location for ANGPTL6 Gene

Chromosome:
19
Start:
10,092,337 bp from pter
End:
10,106,209 bp from pter
Size:
13,873 bases
Orientation:
Minus strand

Genomic View for ANGPTL6 Gene

Genes around ANGPTL6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANGPTL6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANGPTL6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANGPTL6 Gene

Proteins for ANGPTL6 Gene

  • Protein details for ANGPTL6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NI99-ANGL6_HUMAN
    Recommended name:
    Angiopoietin-related protein 6
    Protein Accession:
    Q8NI99
    Secondary Accessions:
    • A5PKV7
    • Q9BZZ0

    Protein attributes for ANGPTL6 Gene

    Size:
    470 amino acids
    Molecular mass:
    51694 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ANGPTL6 Gene

Post-translational modifications for ANGPTL6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ANGPTL6 Gene

Domains & Families for ANGPTL6 Gene

Gene Families for ANGPTL6 Gene

Suggested Antigen Peptide Sequences for ANGPTL6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NI99

UniProtKB/Swiss-Prot:

ANGL6_HUMAN :
  • Contains 1 fibrinogen C-terminal domain.
Domain:
  • Contains 1 fibrinogen C-terminal domain.
genes like me logo Genes that share domains with ANGPTL6: view

Function for ANGPTL6 Gene

Molecular function for ANGPTL6 Gene

UniProtKB/Swiss-Prot Function:
May play a role in the wound healing process. May promote epidermal proliferation, remodeling and regeneration. May promote the chemotactic activity of endothelial cells and induce neovascularization. May counteract high-fat diet-induced obesity and related insulin resistance through increased energy expenditure.
genes like me logo Genes that share phenotypes with ANGPTL6: view

Animal Models for ANGPTL6 Gene

MGI Knock Outs for ANGPTL6:

Animal Model Products

  • Taconic Biosciences Mouse Models for ANGPTL6

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for ANGPTL6 Gene

Localization for ANGPTL6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ANGPTL6 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ANGPTL6 Gene COMPARTMENTS Subcellular localization image for ANGPTL6 gene
Compartment Confidence
extracellular 5
cytosol 2
mitochondrion 2
chloroplast 1
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for ANGPTL6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0030141 secretory granule IEA --
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with ANGPTL6: view

Pathways & Interactions for ANGPTL6 Gene

genes like me logo Genes that share pathways with ANGPTL6: view

Interacting Proteins for ANGPTL6 Gene

Gene Ontology (GO) - Biological Process for ANGPTL6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IEA --
GO:0007275 multicellular organism development IEA --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with ANGPTL6: view

No data available for SIGNOR curated interactions for ANGPTL6 Gene

Drugs & Compounds for ANGPTL6 Gene

(1) Drugs for ANGPTL6 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for ANGPTL6 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ANGPTL6: view

Transcripts for ANGPTL6 Gene

Unigene Clusters for ANGPTL6 Gene

Angiopoietin-like 6:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ANGPTL6 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4
SP1: -
SP2:
SP3:

Relevant External Links for ANGPTL6 Gene

GeneLoc Exon Structure for
ANGPTL6
ECgene alternative splicing isoforms for
ANGPTL6

Expression for ANGPTL6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ANGPTL6 Gene

mRNA differential expression in normal tissues according to GTEx for ANGPTL6 Gene

This gene is overexpressed in Liver (x15.6).

Protein differential expression in normal tissues from HIPED for ANGPTL6 Gene

This gene is overexpressed in Plasma (48.6) and Liver (14.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ANGPTL6 Gene



Protein tissue co-expression partners for ANGPTL6 Gene

NURSA nuclear receptor signaling pathways regulating expression of ANGPTL6 Gene:

ANGPTL6

SOURCE GeneReport for Unigene cluster for ANGPTL6 Gene:

Hs.712850
genes like me logo Genes that share expression patterns with ANGPTL6: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for ANGPTL6 Gene

Orthologs for ANGPTL6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ANGPTL6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ANGPTL6 34 35
  • 98.3 (n)
cow
(Bos Taurus)
Mammalia ANGPTL6 34 35
  • 87.5 (n)
dog
(Canis familiaris)
Mammalia ANGPTL6 34 35
  • 87.39 (n)
mouse
(Mus musculus)
Mammalia Angptl6 34 16 35
  • 76.85 (n)
rat
(Rattus norvegicus)
Mammalia Angptl6 34
  • 76.32 (n)
oppossum
(Monodelphis domestica)
Mammalia ANGPTL6 35
  • 62 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 35
  • 36 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia ANGPTL6 35
  • 49 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.13338 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.12563 34
zebrafish
(Danio rerio)
Actinopterygii angptl6 35
  • 43 (a)
OneToOne
Dr.24020 34
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 34 (a)
OneToMany
Species where no ortholog for ANGPTL6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ANGPTL6 Gene

ENSEMBL:
Gene Tree for ANGPTL6 (if available)
TreeFam:
Gene Tree for ANGPTL6 (if available)

Paralogs for ANGPTL6 Gene

Paralogs for ANGPTL6 Gene

(10) SIMAP similar genes for ANGPTL6 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ANGPTL6: view

Variants for ANGPTL6 Gene

Sequence variations from dbSNP and Humsavar for ANGPTL6 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1551570 other 10,107,354(+) TCCGA(C/T)TGACT intron-variant, upstream-variant-2KB
rs10406526 -- 10,103,823(+) ggcgc(A/G)gtggc intron-variant, upstream-variant-2KB
rs10406558 -- 10,103,891(+) AATTC(A/G)AGACC intron-variant, upstream-variant-2KB
rs10408158 -- 10,103,890(+) CAATT(C/T)GAGAC intron-variant, upstream-variant-2KB
rs10408244 -- 10,096,680(+) GGGCC(C/T)ATAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ANGPTL6 Gene

Variant ID Type Subtype PubMed ID
dgv6266n54 CNV loss 21841781
esv2675304 CNV deletion 23128226
esv29826 CNV loss 19812545
esv3556016 CNV deletion 23714750
esv3643648 CNV loss 21293372
nsv2414 CNV insertion 18451855
nsv458355 CNV loss 19166990
nsv578606 CNV loss 21841781
nsv578610 CNV loss 21841781
nsv833743 CNV loss 17160897

Variation tolerance for ANGPTL6 Gene

Residual Variation Intolerance Score: 70.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.04; 37.48% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ANGPTL6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ANGPTL6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANGPTL6 Gene

Disorders for ANGPTL6 Gene

MalaCards: The human disease database

(3) MalaCards diseases for ANGPTL6 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
gnathomiasis
  • gnathostomiasis
enterobiasis
  • enterobius vermicularis infection
obesity
  • obesity, association with
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ANGPTL6

Genetic Association Database (GAD)
ANGPTL6
Human Genome Epidemiology (HuGE) Navigator
ANGPTL6
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ANGPTL6
genes like me logo Genes that share disorders with ANGPTL6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ANGPTL6 Gene

Publications for ANGPTL6 Gene

  1. Angiopoietin-related growth factor (AGF) promotes epidermal proliferation, remodeling, and regeneration. (PMID: 12871997) Oike Y. … Suda T. (Proc. Natl. Acad. Sci. U.S.A. 2003) 2 3 4 64
  2. Association between angiopoietin-like 6 (ANGPTL6) gene polymorphisms and metabolic syndrome-related phenotypes in the French MONICA Study. (PMID: 19447061) Legry V. … Meirhaeghe A. (Diabetes Metab. 2009) 3 46 64
  3. A genome-wide association study identifies protein quantitative trait loci (pQTLs). (PMID: 18464913) Melzer D. … Ferrucci L. (PLoS Genet. 2008) 3 46 64
  4. Angiopoietin-related growth factor (AGF) supports adhesion, spreading, and migration of keratinocytes, fibroblasts, and endothelial cells through interaction with RGD-binding integrins. (PMID: 16806062) Zhang Y. … Gong Y. (Biochem. Biophys. Res. Commun. 2006) 3 22 64
  5. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PMID: 16335952) Liu T. … Smith R.D. (J. Proteome Res. 2005) 3 4 64

Products for ANGPTL6 Gene

Sources for ANGPTL6 Gene

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