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Aliases for ANGPTL6 Gene

Aliases for ANGPTL6 Gene

  • Angiopoietin Like 6 2 3 5
  • Angiopoietin-Related Protein 5 2 3 4
  • Angiopoietin-Related Growth Factor 3 4
  • Angiopoietin-Like Protein 6 3 4
  • Arp5 3 4
  • AGF 3 4
  • Angiopoietin-Related Protein 6 3
  • Angiopoietin-Like 6 2

External Ids for ANGPTL6 Gene

Previous GeneCards Identifiers for ANGPTL6 Gene

  • GC19M010048
  • GC19M010064
  • GC19M010203
  • GC19M009783

Summaries for ANGPTL6 Gene

GeneCards Summary for ANGPTL6 Gene

ANGPTL6 (Angiopoietin Like 6) is a Protein Coding gene. Diseases associated with ANGPTL6 include Gnathomiasis and Enterobiasis. Among its related pathways are GPCR Pathway and Phospholipase-C Pathway. An important paralog of this gene is ANGPTL2.

UniProtKB/Swiss-Prot for ANGPTL6 Gene

  • May play a role in the wound healing process. May promote epidermal proliferation, remodeling and regeneration. May promote the chemotactic activity of endothelial cells and induce neovascularization. May counteract high-fat diet-induced obesity and related insulin resistance through increased energy expenditure.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANGPTL6 Gene

Genomics for ANGPTL6 Gene

Regulatory Elements for ANGPTL6 Gene

Enhancers for ANGPTL6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G010197 1 Ensembl ENCODE 17.1 -93.5 -93499 4.2 HDGF KLF1 ZMYM3 CEBPG ZNF384 ZBTB40 ZNF316 EGR1 POLR2A NFE2 C19orf66 ANGPTL6 S1PR2 MRPL4 ICAM1 EIF3G P2RY11 SNORD105B SNORD105 PPAN-P2RY11
GH19G010192 1.4 FANTOM5 ENCODE 11.7 -88.1 -88100 3.4 HDGF PKNOX1 CREB3L1 ARNT WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 UBE2L4 ENSG00000267510 LOC100128428 PPAN PPAN-P2RY11 ANGPTL6 ILF3-AS1 LOC100419831 RPL10P15 C19orf66
GH19G010141 0.9 ENCODE 17 -36.9 -36899 2.2 CREB3L1 NFRKB AGO1 ZNF48 ZNF335 ZNF121 ZNF766 PRPF4 SMARCA5 PAF1 EIF3G C19orf66 ANGPTL6 TIMM29 FBXL12 ZNF561 P2RY11 SNORD105B PPAN PPAN-P2RY11
GH19G010191 0.8 ENCODE 11.7 -85.3 -85266 0.9 FOXA2 SAP130 ARID4B MAX CEBPG ZNF384 ZNF644 RAD21 RARA YY1 PPAN PPAN-P2RY11 ANGPTL6 C19orf66 GC19M010177 LOC103689916
GH19G010071 0.7 ENCODE 11.9 +34.9 34910 0.2 MAX RAD21 NR2F2 GABPA YY1 FOXA1 JUND ATF3 GABPB1 HNF4A PPAN-P2RY11 PPAN ANGPTL6 RDH8 COL5A3 EIF3G OLFM2 C19orf66 MIR5589
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ANGPTL6 on UCSC Golden Path with GeneCards custom track

Promoters for ANGPTL6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000106954 -391 1201 PKNOX1 MLX CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9

Genomic Location for ANGPTL6 Gene

Chromosome:
19
Start:
10,092,337 bp from pter
End:
10,106,209 bp from pter
Size:
13,873 bases
Orientation:
Minus strand

Genomic View for ANGPTL6 Gene

Genes around ANGPTL6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANGPTL6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANGPTL6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANGPTL6 Gene

Proteins for ANGPTL6 Gene

  • Protein details for ANGPTL6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NI99-ANGL6_HUMAN
    Recommended name:
    Angiopoietin-related protein 6
    Protein Accession:
    Q8NI99
    Secondary Accessions:
    • A5PKV7
    • Q9BZZ0

    Protein attributes for ANGPTL6 Gene

    Size:
    470 amino acids
    Molecular mass:
    51694 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ANGPTL6 Gene

Post-translational modifications for ANGPTL6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ANGPTL6 Gene

Domains & Families for ANGPTL6 Gene

Gene Families for ANGPTL6 Gene

Suggested Antigen Peptide Sequences for ANGPTL6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ANGPTL6: view

No data available for UniProtKB/Swiss-Prot for ANGPTL6 Gene

Function for ANGPTL6 Gene

Molecular function for ANGPTL6 Gene

UniProtKB/Swiss-Prot Function:
May play a role in the wound healing process. May promote epidermal proliferation, remodeling and regeneration. May promote the chemotactic activity of endothelial cells and induce neovascularization. May counteract high-fat diet-induced obesity and related insulin resistance through increased energy expenditure.
genes like me logo Genes that share phenotypes with ANGPTL6: view

Animal Models for ANGPTL6 Gene

MGI Knock Outs for ANGPTL6:

Animal Model Products

  • Taconic Biosciences Mouse Models for ANGPTL6

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for ANGPTL6 Gene

Localization for ANGPTL6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ANGPTL6 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ANGPTL6 gene
Compartment Confidence
extracellular 5
mitochondrion 2
cytosol 2
lysosome 1

Gene Ontology (GO) - Cellular Components for ANGPTL6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0030141 secretory granule IEA --
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with ANGPTL6: view

Pathways & Interactions for ANGPTL6 Gene

genes like me logo Genes that share pathways with ANGPTL6: view

Gene Ontology (GO) - Biological Process for ANGPTL6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IEA --
GO:0007275 multicellular organism development IEA --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with ANGPTL6: view

No data available for SIGNOR curated interactions for ANGPTL6 Gene

Drugs & Compounds for ANGPTL6 Gene

(1) Drugs for ANGPTL6 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for ANGPTL6 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ANGPTL6: view

Transcripts for ANGPTL6 Gene

Unigene Clusters for ANGPTL6 Gene

Angiopoietin-like 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ANGPTL6 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4
SP1: -
SP2:
SP3:

Relevant External Links for ANGPTL6 Gene

GeneLoc Exon Structure for
ANGPTL6
ECgene alternative splicing isoforms for
ANGPTL6

Expression for ANGPTL6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ANGPTL6 Gene

mRNA differential expression in normal tissues according to GTEx for ANGPTL6 Gene

This gene is overexpressed in Liver (x15.6).

Protein differential expression in normal tissues from HIPED for ANGPTL6 Gene

This gene is overexpressed in Plasma (48.6) and Liver (14.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ANGPTL6 Gene



Protein tissue co-expression partners for ANGPTL6 Gene

NURSA nuclear receptor signaling pathways regulating expression of ANGPTL6 Gene:

ANGPTL6

SOURCE GeneReport for Unigene cluster for ANGPTL6 Gene:

Hs.712850

Evidence on tissue expression from TISSUES for ANGPTL6 Gene

  • Liver(4.3)
  • Bone marrow(4)
genes like me logo Genes that share expression patterns with ANGPTL6: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ANGPTL6 Gene

Orthologs for ANGPTL6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ANGPTL6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ANGPTL6 34 35
  • 98.3 (n)
cow
(Bos Taurus)
Mammalia ANGPTL6 34 35
  • 87.5 (n)
dog
(Canis familiaris)
Mammalia ANGPTL6 34 35
  • 87.39 (n)
mouse
(Mus musculus)
Mammalia Angptl6 34 16 35
  • 76.85 (n)
rat
(Rattus norvegicus)
Mammalia Angptl6 34
  • 76.32 (n)
oppossum
(Monodelphis domestica)
Mammalia ANGPTL6 35
  • 62 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 35
  • 36 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia ANGPTL6 35
  • 49 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.13338 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.12563 34
zebrafish
(Danio rerio)
Actinopterygii angptl6 35
  • 43 (a)
OneToOne
Dr.24020 34
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 34 (a)
OneToMany
Species where no ortholog for ANGPTL6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ANGPTL6 Gene

ENSEMBL:
Gene Tree for ANGPTL6 (if available)
TreeFam:
Gene Tree for ANGPTL6 (if available)

Paralogs for ANGPTL6 Gene

Paralogs for ANGPTL6 Gene

(10) SIMAP similar genes for ANGPTL6 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ANGPTL6: view

Variants for ANGPTL6 Gene

Sequence variations from dbSNP and Humsavar for ANGPTL6 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1551570 other 10,107,354(+) TCCGA(C/T)TGACT intron-variant, upstream-variant-2KB
rs1000134422 -- 10,094,621(+) CCTTA(A/G)AAGTT intron-variant
rs1000143334 -- 10,100,444(+) TTGCC(C/T)AGGCT intron-variant
rs1000270421 -- 10,094,442(+) CGCCC(A/G)GCCAA intron-variant
rs1000522015 -- 10,095,972(+) AGGCT(A/G)CGAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ANGPTL6 Gene

Variant ID Type Subtype PubMed ID
dgv6266n54 CNV loss 21841781
esv2675304 CNV deletion 23128226
esv29826 CNV loss 19812545
esv3556016 CNV deletion 23714750
esv3643648 CNV loss 21293372
nsv2414 CNV insertion 18451855
nsv458355 CNV loss 19166990
nsv578606 CNV loss 21841781
nsv578610 CNV loss 21841781
nsv833743 CNV loss 17160897

Variation tolerance for ANGPTL6 Gene

Residual Variation Intolerance Score: 70.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.04; 37.48% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ANGPTL6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ANGPTL6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANGPTL6 Gene

Disorders for ANGPTL6 Gene

MalaCards: The human disease database

(3) MalaCards diseases for ANGPTL6 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
gnathomiasis
  • gnathostomiasis
enterobiasis
  • enterobius vermicularis infection
obesity
  • obesity, association with
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ANGPTL6

Genetic Association Database (GAD)
ANGPTL6
Human Genome Epidemiology (HuGE) Navigator
ANGPTL6
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ANGPTL6
genes like me logo Genes that share disorders with ANGPTL6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ANGPTL6 Gene

Publications for ANGPTL6 Gene

  1. Angiopoietin-related growth factor (AGF) promotes epidermal proliferation, remodeling, and regeneration. (PMID: 12871997) Oike Y. … Suda T. (Proc. Natl. Acad. Sci. U.S.A. 2003) 2 3 4 64
  2. Association between angiopoietin-like 6 (ANGPTL6) gene polymorphisms and metabolic syndrome-related phenotypes in the French MONICA Study. (PMID: 19447061) Legry V. … Meirhaeghe A. (Diabetes Metab. 2009) 3 46 64
  3. A genome-wide association study identifies protein quantitative trait loci (pQTLs). (PMID: 18464913) Melzer D. … Ferrucci L. (PLoS Genet. 2008) 3 46 64
  4. Angiopoietin-related growth factor (AGF) supports adhesion, spreading, and migration of keratinocytes, fibroblasts, and endothelial cells through interaction with RGD-binding integrins. (PMID: 16806062) Zhang Y. … Gong Y. (Biochem. Biophys. Res. Commun. 2006) 3 22 64
  5. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PMID: 16335952) Liu T. … Smith R.D. (J. Proteome Res. 2005) 3 4 64

Products for ANGPTL6 Gene

  • Cloud-Clone Corp. Antibodies for ANGPTL6
  • Cloud-Clone Corp. Proteins for ANGPTL6
  • Cloud-Clone Corp Assay Kits for ANGPTL6

Sources for ANGPTL6 Gene

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