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Aliases for ANGPTL6 Gene

Aliases for ANGPTL6 Gene

  • Angiopoietin-Like 6 2 3
  • Angiopoietin-Related Protein 5 2 3 4
  • Angiopoietin-Related Growth Factor 3 4
  • Angiopoietin-Like Protein 6 3 4
  • Arp5 3 4
  • AGF 3 4

External Ids for ANGPTL6 Gene

Previous GeneCards Identifiers for ANGPTL6 Gene

  • GC19M010048
  • GC19M010064
  • GC19M010203
  • GC19M009783

Summaries for ANGPTL6 Gene

GeneCards Summary for ANGPTL6 Gene

ANGPTL6 (Angiopoietin-Like 6) is a Protein Coding gene. Diseases associated with ANGPTL6 include enterobiasis and gnathomiasis. Among its related pathways are NF-KappaB Family Pathway and Apoptotic Pathways in Synovial Fibroblasts. An important paralog of this gene is FIBCD1.

UniProtKB/Swiss-Prot for ANGPTL6 Gene

  • May play a role in the wound healing process. May promote epidermal proliferation, remodeling and regeneration. May promote the chemotactic activity of endothelial cells and induce neovascularization. May counteract high-fat diet-induced obesity and related insulin resistance through increased energy expenditure

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANGPTL6 Gene

Genomics for ANGPTL6 Gene

Regulatory Elements for ANGPTL6 Gene

Genomic Location for ANGPTL6 Gene

Chromosome:
19
Start:
10,092,337 bp from pter
End:
10,106,209 bp from pter
Size:
13,873 bases
Orientation:
Minus strand

Genomic View for ANGPTL6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ANGPTL6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANGPTL6 Gene

Proteins for ANGPTL6 Gene

  • Protein details for ANGPTL6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NI99-ANGL6_HUMAN
    Recommended name:
    Angiopoietin-related protein 6
    Protein Accession:
    Q8NI99
    Secondary Accessions:
    • A5PKV7
    • Q9BZZ0

    Protein attributes for ANGPTL6 Gene

    Size:
    470 amino acids
    Molecular mass:
    51694 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ANGPTL6 Gene

Proteomics data for ANGPTL6 Gene at MOPED

Post-translational modifications for ANGPTL6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ANGPTL6 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for ANGPTL6 (Angiopoietin-like Protein 6/ANGPTL6)

No data available for DME Specific Peptides for ANGPTL6 Gene

Domains & Families for ANGPTL6 Gene

Gene Families for ANGPTL6 Gene

Suggested Antigen Peptide Sequences for ANGPTL6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NI99

UniProtKB/Swiss-Prot:

ANGL6_HUMAN :
  • Contains 1 fibrinogen C-terminal domain.
Domain:
  • Contains 1 fibrinogen C-terminal domain.
genes like me logo Genes that share domains with ANGPTL6: view

Function for ANGPTL6 Gene

Molecular function for ANGPTL6 Gene

UniProtKB/Swiss-Prot Function:
May play a role in the wound healing process. May promote epidermal proliferation, remodeling and regeneration. May promote the chemotactic activity of endothelial cells and induce neovascularization. May counteract high-fat diet-induced obesity and related insulin resistance through increased energy expenditure
genes like me logo Genes that share phenotypes with ANGPTL6: view

Animal Models for ANGPTL6 Gene

MGI Knock Outs for ANGPTL6:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ANGPTL6

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , miRNA , Transcription Factor Targets and HOMER Transcription for ANGPTL6 Gene

Localization for ANGPTL6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ANGPTL6 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ANGPTL6 Gene COMPARTMENTS Subcellular localization image for ANGPTL6 gene
Compartment Confidence
extracellular 5
chloroplast 1

Gene Ontology (GO) - Cellular Components for ANGPTL6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030141 secretory granule IEA --
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with ANGPTL6: view

Pathways & Interactions for ANGPTL6 Gene

genes like me logo Genes that share pathways with ANGPTL6: view

Interacting Proteins for ANGPTL6 Gene

Gene Ontology (GO) - Biological Process for ANGPTL6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IEA --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with ANGPTL6: view

No data available for SIGNOR curated interactions for ANGPTL6 Gene

Drugs & Compounds for ANGPTL6 Gene

(2) Additional Compounds for ANGPTL6 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
glucose
LIPID
genes like me logo Genes that share compounds with ANGPTL6: view

Transcripts for ANGPTL6 Gene

Unigene Clusters for ANGPTL6 Gene

Angiopoietin-like 6:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ANGPTL6

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ANGPTL6 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4
SP1: -
SP2:
SP3:

Relevant External Links for ANGPTL6 Gene

GeneLoc Exon Structure for
ANGPTL6
ECgene alternative splicing isoforms for
ANGPTL6

Expression for ANGPTL6 Gene

mRNA expression in normal human tissues for ANGPTL6 Gene

mRNA differential expression in normal tissues according to GTEx for ANGPTL6 Gene

This gene is overexpressed in Liver (x15.6).

Protein differential expression in normal tissues from HIPED for ANGPTL6 Gene

This gene is overexpressed in Plasma (48.6) and Liver (14.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ANGPTL6 Gene



SOURCE GeneReport for Unigene cluster for ANGPTL6 Gene Hs.712850

genes like me logo Genes that share expression patterns with ANGPTL6: view

Protein tissue co-expression partners for ANGPTL6 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for ANGPTL6 Gene

Orthologs for ANGPTL6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ANGPTL6 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ANGPTL6 35
  • 87.5 (n)
  • 90.5 (a)
ANGPTL6 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ANGPTL6 35
  • 87.39 (n)
  • 90.04 (a)
ANGPTL6 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Angptl6 35
  • 76.85 (n)
  • 72.62 (a)
Angptl6 16
Angptl6 36
  • 76 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ANGPTL6 35
  • 98.3 (n)
  • 98.09 (a)
ANGPTL6 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Angptl6 35
  • 76.32 (n)
  • 72.4 (a)
oppossum
(Monodelphis domestica)
Mammalia ANGPTL6 36
  • 62 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 36
  • 36 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia ANGPTL6 36
  • 49 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.13338 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.12563 35
zebrafish
(Danio rerio)
Actinopterygii Dr.24020 35
angptl6 36
  • 43 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 34 (a)
OneToMany
Species with no ortholog for ANGPTL6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ANGPTL6 Gene

ENSEMBL:
Gene Tree for ANGPTL6 (if available)
TreeFam:
Gene Tree for ANGPTL6 (if available)

Paralogs for ANGPTL6 Gene

(10) SIMAP similar genes for ANGPTL6 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ANGPTL6: view

Variants for ANGPTL6 Gene

Sequence variations from dbSNP and Humsavar for ANGPTL6 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs2336689 -- 10,097,439(+) tttct(A/G)ggcac intron-variant
rs4804484 -- 10,103,865(+) CAAGG(C/T)GGGCA upstream-variant-2KB, intron-variant
rs4804485 -- 10,103,993(+) GAGGC(C/T)GAGGC upstream-variant-2KB, intron-variant
rs6511431 -- 10,097,194(+) tgagc(C/T)tagga intron-variant
rs6511432 -- 10,097,332(+) agctg(C/T)gatca intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ANGPTL6 Gene

Variant ID Type Subtype PubMed ID
nsv458355 CNV Loss 19166990
nsv2414 CNV Insertion 18451855
nsv833743 CNV Loss 17160897
esv29826 CNV Loss 19812545
esv2675304 CNV Deletion 23128226

Variation tolerance for ANGPTL6 Gene

Residual Variation Intolerance Score: 70.95% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.04; 37.48% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ANGPTL6 Gene

HapMap Linkage Disequilibrium report
ANGPTL6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANGPTL6 Gene

Disorders for ANGPTL6 Gene

MalaCards: The human disease database

(3) MalaCards diseases for ANGPTL6 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
enterobiasis
  • threadworm infection
gnathomiasis
  • infectious disease by gnathostoma
obesity
  • obesity, association with
- elite association

Relevant External Links for ANGPTL6

Genetic Association Database (GAD)
ANGPTL6
Human Genome Epidemiology (HuGE) Navigator
ANGPTL6
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ANGPTL6
genes like me logo Genes that share disorders with ANGPTL6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ANGPTL6 Gene

Publications for ANGPTL6 Gene

  1. Serum levels of angiopoietin-related growth factor are increased in preeclampsia. (PMID: 19057519) Stepan H. … Fasshauer M. (Am. J. Hypertens. 2009) 23 67
  2. Serum levels of angiopoietin-related growth factor in diabetes mellitus and chronic hemodialysis. (PMID: 19303977) Ebert T. … Fasshauer M. (Metab. Clin. Exp. 2009) 23 67
  3. Angiopoietin-like proteins--potential therapeutic targets for metabolic syndrome and cardiovascular disease. (PMID: 19875897) Oike Y. … Tabata M. (Circ. J. 2009) 23 67
  4. The role of angiopoietin-like proteins in angiogenesis and metabolism. (PMID: 18206803) Hato T. … Oike Y. (Trends Cardiovasc. Med. 2008) 23 67
  5. Angiopoietin-related growth factor enhances blood flow via activation of the ERK1/2-eNOS-NO pathway in a mouse hind-limb ischemia model. (PMID: 18258819) Urano T. … Oike Y. (Arterioscler. Thromb. Vasc. Biol. 2008) 23 67

Products for ANGPTL6 Gene

Sources for ANGPTL6 Gene

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