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ANGPTL6 Gene

protein-coding   GIFtS: 50
GCID: GC19M010203

Angiopoietin-Like 6

  See ANGPTL6-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Angiopoietin-Like 61 2     Angiopoietin-Related Growth Factor2 3
Angiopoietin-Related Protein 51 2 3     ARP52 3
AGF2 3 5     Angiopoietin-Related Protein 62
Angiopoietin-Like Protein 62 3     

External Ids:    HGNC: 231401   Entrez Gene: 838542   Ensembl: ENSG000001308127   OMIM: 6093365   UniProtKB: Q8NI993   

Export aliases for ANGPTL6 gene to outside databases

Previous GC identifers: GC19M010048 GC19M010064 GC19M009783


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ANGPTL6 Gene:
ANGPTL6 (angiopoietin-like 6) is a protein-coding gene. Diseases associated with ANGPTL6 include gnathomiasis, and enterobiasis. An important paralog of this gene is FGL2.

UniProtKB/Swiss-Prot: ANGL6_HUMAN, Q8NI99
Function: May play a role in the wound healing process. May promote epidermal proliferation, remodeling and
regeneration. May promote the chemotactic activity of endothelial cells and induce neovascularization. May
counteract high-fat diet-induced obesity and related insulin resistance through increased energy expenditure




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the ANGPTL6 gene promoter:
         Pax-6   GATA-2   Max   AREB6   FOXO1a   LyF-1   Zic3   FOXO1   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidANGPTL6 promoter sequence
   Search Chromatin IP Primers for ANGPTL6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ANGPTL6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.2   Ensembl cytogenetic band:  19p13.2   HGNC cytogenetic band: 19p13.2

ANGPTL6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ANGPTL6 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M010203:  view genomic region     (about GC identifiers)

Start:
10,203,013 bp from pter      End:
10,213,472 bp from pter
Size:
10,460 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ANGL6_HUMAN, Q8NI99 (See protein sequence)
Recommended Name: Angiopoietin-related protein 6 precursor  
Size: 470 amino acids; 51694 Da
Secondary accessions: A5PKV7 Q9BZZ0

Explore the universe of human proteins at neXtProt for ANGPTL6: NX_Q8NI99

Explore proteomics data for ANGPTL6 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn58, Asn145
  • Modification sites at PhosphoSitePlus

  • See ANGPTL6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_114123.2  
    ENSEMBL proteins: 
     ENSP00000465597   ENSP00000467930   ENSP00000253109  

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    Cloud-Clone Corp. Proteins for ANGPTL6

     
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    antibodies-online proteins for ANGPTL6 (9 products) 

     
    antibodies-online peptides for ANGPTL6

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    antibodies-online antibodies for ANGPTL6 (45 products) 

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    Cloud-Clone Corp. ELISAs for ANGPTL6
    Cloud-Clone Corp. CLIAs for ANGPTL6
    Search eBioscience for ELISAs for ANGPTL6 
    antibodies-online kits for ANGPTL6 (17 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    FIBC: Fibrinogen C domain containing

    4 InterPro protein domains:
     IPR014715 Fibrinogen_a/b/g_C_2
     IPR014716 Fibrinogen_a/b/g_C_1
     IPR020837 Fibrinogen_CS
     IPR002181 Fibrinogen_a/b/g_C_dom

    Graphical View of Domain Structure for InterPro Entry Q8NI99

    ProtoNet protein and cluster: Q8NI99

    1 Blocks protein domain: IPB002181 Fibrinogen

    UniProtKB/Swiss-Prot: ANGL6_HUMAN, Q8NI99
    Similarity: Contains 1 fibrinogen C-terminal domain


    Find genes that share domains with ANGPTL6           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ANGL6_HUMAN, Q8NI99
    Function: May play a role in the wound healing process. May promote epidermal proliferation, remodeling and
    regeneration. May promote the chemotactic activity of endothelial cells and induce neovascularization. May
    counteract high-fat diet-induced obesity and related insulin resistance through increased energy expenditure

    Phenotypes:
         2 GenomeRNAi human phenotypes for ANGPTL6:

     Decreased POU5F1-GFP protein e  Decreased viability of wild-ty 

         6 MGI mutant phenotypes (inferred from 1 allele(MGI details for Angptl6):
     adipose tissue  cardiovascular system  embryogenesis  growth/size/body  homeostasis/metabolism 
     mortality/aging 

    Find genes that share phenotypes with ANGPTL6           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Angptl6tm1Yo for ANGPTL6

       genOway: Develop your customized and physiologically relevant rodent model for ANGPTL6

    miRNA
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    hsa-miR-370 hsa-miR-556-5p hsa-miR-3670 hsa-miR-3150a-3p
    SwitchGear 3'UTR luciferase reporter plasmidANGPTL6 3' UTR sequence
    Inhib. RNA
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ANGPTL6

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANGPTL6


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ANGL6_HUMAN, Q8NI99: Secreted (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular4
    cytosol2
    mitochondrion2
    chloroplast1
    lysosome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0030141secretory granule IEA--

    Find genes that share ontologies with ANGPTL6           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ANGPTL6 About   (see all 12)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Apoptotic Pathways in Synovial Fibroblasts
    Mitochondrial Apoptosis0.85
    Rac1 Pathway0.65
    Cellular Apoptosis Pathway0.85
    Glioma Invasiveness0.64
    Apoptotic Pathways in Synovial Fibroblasts0.84
    Actin-Based Motility by Rho Family GTPases0.62
    p53 Mediated Apoptosis0.84
    ERK5 Signaling0.61
    2GPCR Pathway
    Ras Pathway0.73
    Breast Cancer Regulation by Stathmin10.58
    Paxillin Interactions0.73
    NFAT in Immune Response0.58
    GPCR Pathway0.62
    Estrogen Pathway0.55
    Pancreatic Adenocarcinoma0.59
    3ERK Signaling
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    ILK Signaling0.49
    MAPK Signaling0.58
    4Nanog in Mammalian ESC Pluripotency
    Nanog in Mammalian ESC Pluripotency0.61
    14-3-3 Induced Intracellular Signaling0.59
    GSK3 Signaling0.61
    eNOS Signaling0.48
    5TGF-Beta Pathway
    TGF-Beta Pathway0.60
    JAK-STAT Pathway0.57
    MAPK Family Pathway0.60
    JNK Pathway0.51

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for ANGPTL6 (see all 54)
        Nuclear Receptor Activation by Vitamin-A
    Paxillin Interactions
    Telomerase Components in Cell Signaling
    Mitochondrial Apoptosis
    Molecular Mechanisms of Cancer



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ANGPTL6
    Interactions:

        Search GeneGlobe Interaction Network for ANGPTL6

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis IEA--
    GO:0030154cell differentiation IEA--

    Find genes that share ontologies with ANGPTL6           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ANGPTL6 (ANGL6)

    2 Novoseek inferred chemical compound relationships for ANGPTL6 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lipid 28.3 3 18206803 (1), 19057519 (1), 19303977 (1)
    glucose 4.72 4 19303977 (2), 18206803 (1), 19057519 (1)



    Find genes that share compounds with ANGPTL6           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ANGPTL6 gene: 
    NM_031917.2  

    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000589181 ENST00000592641 ENST00000253109(uc002mmx.2 uc002mmy.1)
    ENST00000586910
    miRNA
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    4 qRT-PCR Assays for microRNAs that regulate ANGPTL6:
    hsa-miR-370 hsa-miR-556-5p hsa-miR-3670 hsa-miR-3150a-3p
    SwitchGear 3'UTR luciferase reporter plasmidANGPTL6 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ANGPTL6
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    GenScript: all cDNA clones in your preferred vector: ANGPTL6 (NM_031917)
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    OriGene qPCR primer pairs and template standards for ANGPTL6
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ANGPTL6
      QuantiTect SYBR Green Assays in human, mouse, rat ANGPTL6
      QuantiFast Probe-based Assays in human, mouse, rat ANGPTL6

    Selected AceView cDNA sequences (see all 31):

    AB054064 CR621970 NM_031917 AY358276 CR591845 CR617920 BX364683 AI332587 
    AA919135 BX402446 BX364684 AL543746 AF230330 BX381710 AI394424 BX381709 
    BX355859 BX406820 AA313128 AI806111 AW177634 AL570222 BF848700 AL545641 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for ANGPTL6    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4
    SP1:        -                     
    SP2:                              
    SP3:                              


    ECgene alternative splicing isoforms for ANGPTL6

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ANGPTL6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTCATTCGGC
    ANGPTL6 Expression
    About this image

    ANGPTL6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ANGPTL6 Protein Expression
        Custom PCR Arrays for ANGPTL6
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANGPTL6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ANGPTL6 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Angptl61 , 5 angiopoietin-like 61, 5 76.85(n)1
    72.62(a)1
      9 (7.66 cM)5
    707261  NM_145154.21  NP_660136.11 
     208738095 
    chicken
    (Gallus gallus)
    Aves --
    Uncharacterized protein
    36(a)
    many ↔ many
    1(169771126-169787231)
    lizard
    (Anolis carolinensis)
    Reptilia ANGPTL66
    angiopoietin-like 6
    49(a)
    1 ↔ 1
    GL343414.1(511652-536409)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.125632 Xenopus laevis transcribed sequence with moderate similarity more 75.13(n)    BJ087915.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.240202 Danio rerio cDNA clone IMAGE2640087, partial cds 73.36(n)    BC055229.1 


    ENSEMBL Gene Tree for ANGPTL6 (if available)
    TreeFam Gene Tree for ANGPTL6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ANGPTL6 gene
    FGL22  ANGPT42  FGG2  FIBCD12  FCN32  ANGPTL22  FCN22  FCN12  
    ANGPT12  ANGPTL12  ANGPTL72  FGB2  ANGPT22  MFAP42  FGL12  
    10 SIMAP similar genes for ANGPTL6 using alignment to 2 protein entries:     ANGL6_HUMAN (see all proteins):
    ANGPTL2    ANGPTL1    ANGPTL7    ANGPT1    FGL1    FIBCD1
    FCN3    FCN2    FGB    FCN1

    Find genes that share paralogs with ANGPTL6           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ANGPTL6 (see all 249)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2016225891,2
    C--10204469(+) ATACTC/GACACT 2 S * stg10--------
    rs1997650751,2
    C--10204491(+) CACTCA/GCAGTT 2 R * stg10--------
    rs1407613961,2
    F--10204494(+) TCGCAG/ATTCAT 2 /L syn11Minor allele frequency- A:0.00NA 4552
    rs1501177681,2
    C,F--10204529(+) CCTGGC/AGGGCC 2 /R /L mis12Minor allele frequency- A:0.00NA EU 5853
    rs1823453211,2
    C--10204530(+) CTGGCA/GGGCCT 2 R C mis10--------
    rs1874222951,2
    C,F--10204575(+) GATAGG/CGGGGA 1 -- int11Minor allele frequency- C:0.00EU 1109
    rs1492844351,2
    --10204671(+) TCCCAC/GTTTTC 1 -- int10--------
    rs1134844911,2
    C,F--10204826(+) CTGGGG/TTTCTT 1 -- int13Minor allele frequency- T:0.09CSA WA 122
    rs1909586341,2
    --10204947(+) CCTCCC/TGAGCA 1 -- int10--------
    rs584967111,2
    C,F--10204959(+) CTGGGT/ACTACA 1 -- int12Minor allele frequency- A:0.50NA WA 4

    HapMap Linkage Disequilibrium report for ANGPTL6 (10203013 - 10213472 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for ANGPTL6:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2675304CNV Deletion23128226
    nsv2414CNV Insertion18451855
    nsv833743CNV Loss17160897
    esv29826CNV Loss19812545
    nsv458355CNV Loss19166990

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ANGPTL6
    DNA2.0 Custom Variant and Variant Library Synthesis for ANGPTL6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609336    OMIM disorders: --

    2 diseases for ANGPTL6:    
    About MalaCards
    gnathomiasis    enterobiasis

    3 diseases from the University of Copenhagen DISEASES database for ANGPTL6:
    Enterobiasis     Dental caries     Gnathomiasis

    Find genes that share disorders with ANGPTL6           About GenesLikeMe

    1 Novoseek inferred disease relationship for ANGPTL6 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inflammation 6.77 2 19057519 (1), 19303977 (1)

    Genetic Association Database (GAD): ANGPTL6
    Human Genome Epidemiology (HuGE) Navigator: ANGPTL6 (1 document)

    Export disorders for ANGPTL6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ANGPTL6 gene, integrated from 10 sources (see all 24):
    (articles sorted by number of sources associating them with ANGPTL6)
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    1. Angiopoietin-related growth factor (AGF) promotes epidermal proliferation, remodeling, and regeneration. (PubMed id 12871997)1, 2, 3 Oike Y.... Suda T. (Proc. Natl. Acad. Sci. U.S.A. 2003)
    2. Association between angiopoietin-like 6 (ANGPTL6) gene polymorphisms and metabolic syndrome-related phenotypes in the French MONICA Study. (PubMed id 19447061)1, 4 Legry V....Meirhaeghe A. (amp 2009)
    3. A genome-wide association study identifies protein quantitative trait loci (pQTLs). (PubMed id 18464913)1, 4 Melzer D....Ferrucci L. (PLoS Genet. 2008)
    4. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (J. Proteome Res. 2005)
    5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    6. Angiopoietin-related growth factor (AGF) supports adhesion, spreading, and migration of keratinocytes, fibroblasts, and endothelial cells through interaction with RGD-binding integrins. (PubMed id 16806062)1, 9 Zhang Y....Gong Y. (Biochem. Biophys. Res. Commun. 2006)
    7. Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans. (PubMed id 23400010)1 Del-Aguila J.L....Boerwinkle E. (Pharmacogenomics J. 2013)
    8. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    9. Serum levels of angiopoietin-related growth factor (AGF) are increased in polycystic ovary syndrome. (PubMed id 22406517)1 Boztosun A....MA1derris I.I. (J. Investig. Med. 2012)
    10. A complex of I+6 integrin and E-cadherin drives liver metastasis of colorectal cancer cells through hepatic angiopoietin-like 6. (PubMed id 23070965)1 MarchiA^ S....Bussolino F. (EMBO Mol Med 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 83854 HGNC: 23140 AceView: ANGPTL6 Ensembl:ENSG00000130812 euGenes: HUgn83854
    ECgene: ANGPTL6 H-InvDB: ANGPTL6

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ANGPTL6 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ANGPTL6 gene:
    Search GeneIP for patents involving ANGPTL6

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