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Aliases for ANGPTL5 Gene

Aliases for ANGPTL5 Gene

  • Angiopoietin Like 5 2 3 5
  • Angiopoietin-Like Protein 5 4
  • Angiopoietin-Like 5 2

External Ids for ANGPTL5 Gene

Previous GeneCards Identifiers for ANGPTL5 Gene

  • GC00U902896
  • GC11M101795
  • GC11M101299
  • GC11M101266
  • GC11M097686

Summaries for ANGPTL5 Gene

GeneCards Summary for ANGPTL5 Gene

ANGPTL5 (Angiopoietin Like 5) is a Protein Coding gene. Among its related pathways are Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANGPTL5 Gene

Genomics for ANGPTL5 Gene

Regulatory Elements for ANGPTL5 Gene

Enhancers for ANGPTL5 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ANGPTL5 on UCSC Golden Path with GeneCards custom track

Promoters for ANGPTL5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ANGPTL5 on UCSC Golden Path with GeneCards custom track

Genomic Location for ANGPTL5 Gene

Chromosome:
11
Start:
101,890,674 bp from pter
End:
101,916,715 bp from pter
Size:
26,042 bases
Orientation:
Minus strand

Genomic View for ANGPTL5 Gene

Genes around ANGPTL5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANGPTL5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANGPTL5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANGPTL5 Gene

Proteins for ANGPTL5 Gene

  • Protein details for ANGPTL5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86XS5-ANGL5_HUMAN
    Recommended name:
    Angiopoietin-related protein 5
    Protein Accession:
    Q86XS5
    Secondary Accessions:
    • A8K658
    • Q86VR9

    Protein attributes for ANGPTL5 Gene

    Size:
    388 amino acids
    Molecular mass:
    44144 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ANGPTL5 Gene

Proteomics data for ANGPTL5 Gene at MOPED

Post-translational modifications for ANGPTL5 Gene

  • Glycosylation at Asn 53, Asn 238, and Asn 329
  • Modification sites at PhosphoSitePlus

Other Protein References for ANGPTL5 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cloud-Clone Corp. Antibodies for ANGPTL5

No data available for DME Specific Peptides for ANGPTL5 Gene

Domains & Families for ANGPTL5 Gene

Gene Families for ANGPTL5 Gene

Suggested Antigen Peptide Sequences for ANGPTL5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86XS5

UniProtKB/Swiss-Prot:

ANGL5_HUMAN :
  • Contains 1 fibrinogen C-terminal domain.
Domain:
  • Contains 1 fibrinogen C-terminal domain.
genes like me logo Genes that share domains with ANGPTL5: view

Function for ANGPTL5 Gene

Phenotypes for ANGPTL5 Gene

genes like me logo Genes that share phenotypes with ANGPTL5: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ANGPTL5 Gene

Localization for ANGPTL5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ANGPTL5 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ANGPTL5 Gene COMPARTMENTS Subcellular localization image for ANGPTL5 gene
Compartment Confidence
extracellular 5

No data available for Gene Ontology (GO) - Cellular Components for ANGPTL5 Gene

Pathways & Interactions for ANGPTL5 Gene

genes like me logo Genes that share pathways with ANGPTL5: view

Pathways by source for ANGPTL5 Gene

Interacting Proteins for ANGPTL5 Gene

Gene Ontology (GO) - Biological Process for ANGPTL5 Gene

None

No data available for SIGNOR curated interactions for ANGPTL5 Gene

Drugs & Compounds for ANGPTL5 Gene

No Compound Related Data Available

Transcripts for ANGPTL5 Gene

mRNA/cDNA for ANGPTL5 Gene

(2) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(11) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ANGPTL5 Gene

Angiopoietin-like 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ANGPTL5 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b
SP1:
SP2: -

Relevant External Links for ANGPTL5 Gene

GeneLoc Exon Structure for
ANGPTL5
ECgene alternative splicing isoforms for
ANGPTL5

Expression for ANGPTL5 Gene

mRNA expression in normal human tissues for ANGPTL5 Gene

mRNA differential expression in normal tissues according to GTEx for ANGPTL5 Gene

This gene is overexpressed in Ovary (x12.4) and Adipose - Subcutaneous (x5.9).

Protein differential expression in normal tissues from HIPED for ANGPTL5 Gene

This gene is overexpressed in Liver (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ANGPTL5 Gene



SOURCE GeneReport for Unigene cluster for ANGPTL5 Gene Hs.318370

mRNA Expression by UniProt/SwissProt for ANGPTL5 Gene

Q86XS5-ANGL5_HUMAN
Tissue specificity: Mainly expressed in adult heart.
genes like me logo Genes that share expression patterns with ANGPTL5: view

Protein tissue co-expression partners for ANGPTL5 Gene

Primer Products

Orthologs for ANGPTL5 Gene

This gene was present in the common ancestor of animals.

Orthologs for ANGPTL5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ANGPTL5 35
  • 90.12 (n)
  • 87.11 (a)
ANGPTL5 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ANGPTL5 35
  • 88.14 (n)
  • 88.92 (a)
ANGPTL5 36
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ANGPTL5 35
  • 99.05 (n)
  • 98.97 (a)
ANGPTL5 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ANGPTL5 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ANGPTL5 36
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves ANGPTL5 35
  • 72.52 (n)
  • 68.73 (a)
ANGPTL5 36
  • 68 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ANGPTL5 36
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia angptl5 35
  • 65.57 (n)
  • 61.37 (a)
zebrafish
(Danio rerio)
Actinopterygii angptl5 35
  • 59.12 (n)
  • 52.29 (a)
angptl5 36
  • 48 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG7668 36
  • 21 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea T15B7.1 36
  • 19 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 30 (a)
OneToOne
Species with no ortholog for ANGPTL5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ANGPTL5 Gene

ENSEMBL:
Gene Tree for ANGPTL5 (if available)
TreeFam:
Gene Tree for ANGPTL5 (if available)

Paralogs for ANGPTL5 Gene

(5) SIMAP similar genes for ANGPTL5 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ANGPTL5: view

No data available for Paralogs for ANGPTL5 Gene

Variants for ANGPTL5 Gene

Sequence variations from dbSNP and Humsavar for ANGPTL5 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs7946238 - 101,902,638(+) GCTAG(A/G)TCCTT intron-variant, reference, missense
rs949158 -- 101,909,543(-) AATTT(G/T)GTAAG intron-variant
rs1004352 -- 101,906,420(-) ATTTT(C/T)TCTTA intron-variant
rs1372412 -- 101,903,247(+) CCCAA(A/G)AAATT intron-variant
rs1470197 -- 101,895,524(+) AGAAA(A/C)ATTTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ANGPTL5 Gene

Variant ID Type Subtype PubMed ID
nsv832250 CNV Gain 17160897

Variation tolerance for ANGPTL5 Gene

Residual Variation Intolerance Score: 92.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.27; 62.57% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ANGPTL5 Gene

Human Gene Mutation Database (HGMD)
ANGPTL5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANGPTL5 Gene

Disorders for ANGPTL5 Gene

Relevant External Links for ANGPTL5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ANGPTL5

No disorders were found for ANGPTL5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANGPTL5 Gene

Publications for ANGPTL5 Gene

  1. Identification of a novel human angiopoietin-like gene expressed mainly in heart. (PMID: 12624729) Zeng L. … Mao Y. (J. Hum. Genet. 2003) 2 3 4 23 67
  2. Genome-wide data reveal novel genes for methotrexate response in a large cohort of juvenile idiopathic arthritis cases. (PMID: 24709693) Cobb J. … Thomson W. (Pharmacogenomics J. 2014) 3
  3. Human CD34+ CD133+ hematopoietic stem cells cultured with growth factors including Angptl5 efficiently engraft adult NOD-SCID Il2rI^-/- (NSG) mice. (PMID: 21559522) Drake A.C. … Chen J. (PLoS ONE 2011) 3
  4. Impacts of angiopoietin-like proteins on lipoprotein metabolism and cardiovascular events. (PMID: 19851103) Miida T. … Hirayama S. (Curr. Opin. Lipidol. 2010) 23
  5. Rare loss-of-function mutations in ANGPTL family members contribute to plasma triglyceride levels in humans. (PMID: 19075393) Romeo S. … Cohen J.C. (J. Clin. Invest. 2009) 23

Products for ANGPTL5 Gene

Sources for ANGPTL5 Gene

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