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Aliases for ANGPTL5 Gene

Aliases for ANGPTL5 Gene

  • Angiopoietin Like 5 2 3 5
  • Angiopoietin-Like Protein 5 4
  • Angiopoietin-Like 5 2

External Ids for ANGPTL5 Gene

Previous GeneCards Identifiers for ANGPTL5 Gene

  • GC00U902896
  • GC11M101795
  • GC11M101299
  • GC11M101266
  • GC11M097686

Summaries for ANGPTL5 Gene

GeneCards Summary for ANGPTL5 Gene

ANGPTL5 (Angiopoietin Like 5) is a Protein Coding gene. Among its related pathways are Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers. An important paralog of this gene is TNR.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANGPTL5 Gene

Genomics for ANGPTL5 Gene

Regulatory Elements for ANGPTL5 Gene

Enhancers for ANGPTL5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F101911 1.1 ENCODE 9.8 +2.5 2462 5.0 HDGF PKNOX1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF263 SP3 TRPC6 ANGPTL5 CEP126
GH11F102010 1.4 FANTOM5 Ensembl ENCODE 5.2 -94.8 -94769 2.8 PKNOX1 KLF17 ARID4B SIN3A RAD21 BRCA1 RCOR1 KLF7 FOS SMARCC1 TRPC6 CEP126 ANGPTL5 GC11P102001 C11orf70
GH11F102006 1.2 Ensembl ENCODE 5.7 -90.7 -90742 1.8 ELF3 PKNOX1 ARID4B RAD21 RARA RFX5 SLC30A9 CREM MIXL1 THAP11 TRPC6 ANGPTL5 GC11P102001 C11orf70
GH11F102558 1.4 FANTOM5 Ensembl ENCODE 4.1 -644.3 -644331 4.3 HDGF TBP PKNOX1 TBL1XR1 FEZF1 ZBTB40 CBX5 ZNF143 ETV6 CREM MMP7 DYNC2H1 MMP20 CEP126 ENSG00000256916 BIRC2 MMP10 ANGPTL5 BIRC3
GH11F102563 1.1 Ensembl ENCODE 5 -647.7 -647659 2.0 JUN BACH1 ZNF316 STAT2 NFE2 FOS MAFK TCF7L2 NFE2L2 SMARCE1 MMP7 ENSG00000256916 MMP20 ANGPTL5
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ANGPTL5 on UCSC Golden Path with GeneCards custom track

Promoters for ANGPTL5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001572842 1415 2201 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF263 SP3 NFYC

Genomic Location for ANGPTL5 Gene

Chromosome:
11
Start:
101,890,674 bp from pter
End:
101,916,715 bp from pter
Size:
26,042 bases
Orientation:
Minus strand

Genomic View for ANGPTL5 Gene

Genes around ANGPTL5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANGPTL5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANGPTL5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANGPTL5 Gene

Proteins for ANGPTL5 Gene

  • Protein details for ANGPTL5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86XS5-ANGL5_HUMAN
    Recommended name:
    Angiopoietin-related protein 5
    Protein Accession:
    Q86XS5
    Secondary Accessions:
    • A8K658
    • Q86VR9

    Protein attributes for ANGPTL5 Gene

    Size:
    388 amino acids
    Molecular mass:
    44144 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ANGPTL5 Gene

Post-translational modifications for ANGPTL5 Gene

  • Glycosylation at Asn 53, Asn 238, and Asn 329
  • Modification sites at PhosphoSitePlus

Other Protein References for ANGPTL5 Gene

Antibody Products

  • Abcam antibodies for ANGPTL5
  • Cloud-Clone Corp. Antibodies for ANGPTL5

Protein Products

  • Enzo Life Sciences proteins for ANGPTL5
  • Cloud-Clone Corp. Proteins for ANGPTL5
  • Abcam proteins for ANGPTL5

No data available for DME Specific Peptides for ANGPTL5 Gene

Domains & Families for ANGPTL5 Gene

Gene Families for ANGPTL5 Gene

Suggested Antigen Peptide Sequences for ANGPTL5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86XS5

UniProtKB/Swiss-Prot:

ANGL5_HUMAN :
  • Contains 1 fibrinogen C-terminal domain.
Domain:
  • Contains 1 fibrinogen C-terminal domain.
genes like me logo Genes that share domains with ANGPTL5: view

Function for ANGPTL5 Gene

Phenotypes for ANGPTL5 Gene

genes like me logo Genes that share phenotypes with ANGPTL5: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ANGPTL5 Gene

Localization for ANGPTL5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ANGPTL5 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ANGPTL5 gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for ANGPTL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with ANGPTL5: view

Pathways & Interactions for ANGPTL5 Gene

genes like me logo Genes that share pathways with ANGPTL5: view

Pathways by source for ANGPTL5 Gene

Interacting Proteins for ANGPTL5 Gene

Gene Ontology (GO) - Biological Process for ANGPTL5 Gene

None

No data available for SIGNOR curated interactions for ANGPTL5 Gene

Transcripts for ANGPTL5 Gene

mRNA/cDNA for ANGPTL5 Gene

(3) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(11) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ANGPTL5 Gene

Angiopoietin-like 5:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ANGPTL5 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b
SP1:
SP2: -

Relevant External Links for ANGPTL5 Gene

GeneLoc Exon Structure for
ANGPTL5
ECgene alternative splicing isoforms for
ANGPTL5

Expression for ANGPTL5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ANGPTL5 Gene

mRNA differential expression in normal tissues according to GTEx for ANGPTL5 Gene

This gene is overexpressed in Ovary (x12.4) and Adipose - Subcutaneous (x5.9).

Protein differential expression in normal tissues from HIPED for ANGPTL5 Gene

This gene is overexpressed in Liver (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ANGPTL5 Gene



Protein tissue co-expression partners for ANGPTL5 Gene

NURSA nuclear receptor signaling pathways regulating expression of ANGPTL5 Gene:

ANGPTL5

SOURCE GeneReport for Unigene cluster for ANGPTL5 Gene:

Hs.318370

mRNA Expression by UniProt/SwissProt for ANGPTL5 Gene:

Q86XS5-ANGL5_HUMAN
Tissue specificity: Mainly expressed in adult heart.
genes like me logo Genes that share expression patterns with ANGPTL5: view

Primer Products

Orthologs for ANGPTL5 Gene

This gene was present in the common ancestor of animals.

Orthologs for ANGPTL5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ANGPTL5 34 35
  • 99.05 (n)
cow
(Bos Taurus)
Mammalia ANGPTL5 34 35
  • 90.12 (n)
dog
(Canis familiaris)
Mammalia ANGPTL5 34 35
  • 88.14 (n)
oppossum
(Monodelphis domestica)
Mammalia ANGPTL5 35
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ANGPTL5 35
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves ANGPTL5 34 35
  • 72.52 (n)
lizard
(Anolis carolinensis)
Reptilia ANGPTL5 35
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia angptl5 34
  • 65.57 (n)
zebrafish
(Danio rerio)
Actinopterygii angptl5 34 35
  • 59.12 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG7668 35
  • 21 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea T15B7.1 35
  • 19 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 30 (a)
OneToOne
Species where no ortholog for ANGPTL5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ANGPTL5 Gene

ENSEMBL:
Gene Tree for ANGPTL5 (if available)
TreeFam:
Gene Tree for ANGPTL5 (if available)

Paralogs for ANGPTL5 Gene

Paralogs for ANGPTL5 Gene

(5) SIMAP similar genes for ANGPTL5 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ANGPTL5: view

Variants for ANGPTL5 Gene

Sequence variations from dbSNP and Humsavar for ANGPTL5 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1004352 -- 101,906,420(-) ATTTT(C/T)TCTTA intron-variant
rs10047467 -- 101,890,280(+) TAGCT(A/G)TGTCA downstream-variant-500B
rs10501993 -- 101,892,761(+) GCAAT(C/T)TGTGG intron-variant
rs10562844 -- 101,910,426(+) AAAAA(A/T)ATATA intron-variant
rs10750623 -- 101,912,080(+) AATAT(A/G)TTCTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ANGPTL5 Gene

Variant ID Type Subtype PubMed ID
nsv832250 CNV gain 17160897
nsv1052159 CNV gain 25217958

Variation tolerance for ANGPTL5 Gene

Residual Variation Intolerance Score: 92.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.27; 62.57% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ANGPTL5 Gene

Human Gene Mutation Database (HGMD)
ANGPTL5
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ANGPTL5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANGPTL5 Gene

Disorders for ANGPTL5 Gene

Relevant External Links for ANGPTL5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ANGPTL5

No disorders were found for ANGPTL5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANGPTL5 Gene

Publications for ANGPTL5 Gene

  1. Identification of a novel human angiopoietin-like gene expressed mainly in heart. (PMID: 12624729) Zeng L. … Mao Y. (J. Hum. Genet. 2003) 2 3 4 22 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 64
  4. Genome-wide data reveal novel genes for methotrexate response in a large cohort of juvenile idiopathic arthritis cases. (PMID: 24709693) Cobb J. … Thomson W. (Pharmacogenomics J. 2014) 3 64
  5. Human CD34+ CD133+ hematopoietic stem cells cultured with growth factors including Angptl5 efficiently engraft adult NOD-SCID Il2rI^-/- (NSG) mice. (PMID: 21559522) Drake A.C. … Chen J. (PLoS ONE 2011) 3 64

Products for ANGPTL5 Gene

Sources for ANGPTL5 Gene

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