ANGPTL5 Gene
protein-coding GIFtS: 48
GCID: GC11M101795
|
|
angiopoietin-like 5
| |
Aliases
for ANGPTL5 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Angiopoietin-Like 51 2 | | Angiopoietin-Like Protein 52 3 | | Angiopoietin-Related Protein 52 |
Export aliases for ANGPTL5 gene to outside databasesPrevious GC identifers: GC00U902896 GC11M101299 GC11M101266 GC11M097686 |
Summaries
for ANGPTL5 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for ANGPTL5 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_033899.8
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ANGPTL5 gene promoter:
Sox5 AP-4 Evi-1 CREB S8 FOXJ2 (long isoform) deltaCREB FOXJ2 TGIF
Other transcription factors
Search SABiosciences Chromatin IP Primers for ANGPTL5
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ANGPTL5 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11q22.1 Ensembl cytogenetic band: 11q22.1 HGNC cytogenetic band: 11q22.2ANGPTL5 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11M101795: view genomic region
(about GC identifiers)
Start:
|
101,761,405 bp from pter |
End:
|
101,787,253 bp from pter |
Size:
|
25,849 bases |
Orientation:
|
minus strand |
|
Proteins
for ANGPTL5 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ANGL5_HUMAN, Q86XS5 (See
protein sequence)Recommended Name: Angiopoietin-related protein 5 precursor Size: 388 amino acids; 44144 Da
Subcellular location: Secreted (Potential)
Secondary accessions: A8K658 Q86VR9Explore the universe of human proteins at neXtProt for ANGPTL5: NX_Q86XS5
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q86XS5
ANGPTL5 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_835228.2
ENSEMBL proteins: ENSP00000335255 ENSP00000433562
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005615 | extracellular space |
IEA | -- |
ANGPTL5 for ontologies About GeneDecksing
ANGPTL5 Antibody Products:
Assay Products for ANGPTL5: |
Protein
Domains /
Families
for ANGPTL5 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ANGPTL5 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q86XS5ProtoNet protein and cluster: Q86XS5 1 Blocks protein family: IPB002181 Fibrinogen
UniProtKB/Swiss-Prot: ANGL5_HUMAN, Q86XS5Similarity: Contains 1 fibrinogen C-terminal domain |
Function
for ANGPTL5 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ANGPTL5
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ANGPTL5
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANGPTL5 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005102 | receptor binding |
IEA | -- |
ANGPTL5 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for ANGPTL5:
|
Pathways & Interactions
for ANGPTL5 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ANGPTL5
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007165 | signal transduction |
IEA | -- |
ANGPTL5 for ontologies About GeneDecksing
|
Drugs & Compounds
for ANGPTL5 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ANGPTL5
Search CenterWatch for drugs/clinical trials and news about ANGPTL5 / ANGL5
|
Transcripts
for ANGPTL5 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ANGPTL5 gene: NM_178127.4 Unigene Cluster for ANGPTL5: Angiopoietin-like 5 Hs.318370 [show with all ESTs]Unigene Representative Sequence: BC0491702 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000334289(uc001pgl.3) ENST00000534527
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ANGPTL5
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ANGPTL5 (NM_178127) | | | DNA2.0 Custom Codon Optimized Gene
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Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ANGPTL5
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat ANGPTL5 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ANGPTL5 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ANGPTL5 |
Additional cDNA sequence: AK291523.1 AY169281.1 AY358827.1 BC049170.1 BC053957.1 2 DOTS entries: DT.91676114 DT.91993004 11 AceView cDNA sequences: BQ882239 BQ722746 AY169281 NM_178127 BC053957 BI596365 BC049170 AY358827 BF198009 BQ181216 BG706284
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for ANGPTL5 About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | - | | | | | | | | | | | |
ECgene alternative splicing isoforms for ANGPTL5
|
Expression
for ANGPTL5 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ANGPTL5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTTAACTATT
About this image
See ANGPTL5 Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.318370
UniProtKB/Swiss-Prot: ANGL5_HUMAN, Q86XS5Tissue specificity: Mainly expressed in adult heart
SABiosciences Custom PCR Arrays for ANGPTL5
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ANGPTL5
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat ANGPTL5 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ANGPTL5 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ANGPTL5 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANGPTL5 |
Orthologs
for ANGPTL5 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for ANGPTL5 gene from 3/8 species (see all 8) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
ANGPTL51 |
angiopoietin-like 5 |
73.33(n)
69.47(a) |
|
772036 NM_001197236.1 NP_001184165.1 |
lizard
(Anolis carolinensis) |
Reptilia |
ANGPTL56 |
-- |
74(a) |
1 ↔ 1 |
3(192558070-192574691) |
zebrafish
(Danio rerio) |
Actinopterygii |
570616842 |
-- |
73.44(n) |
|
57061684 |
ENSEMBL Gene Tree for ANGPTL5 (if available)
TreeFam Gene Tree for ANGPTL5 (if available) |
Paralogs
for ANGPTL5 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ANGPTL5 gene
- TNR2 FIBCD12 FCN32 FCN12 FCN22 TNXB2 TNN2 MFAP42
- FN12 TNC2
5 SIMAP similar genes for ANGPTL5 using alignment to 2 protein entries: ANGL5_HUMAN (see all proteins):FCN3 ANGPTL2 MFAP4 FGL1 LFIRE1
ANGPTL5 for paralogs About GeneDecksing
|
Genomic Variants
for ANGPTL5 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ANGPTL5 (101761405 - 101787253 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ANGPTL5: --
Human Gene Mutation Database (HGMD): ANGPTL5
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ANGPTL5 |
|
Disorders
/ Diseases
for ANGPTL5 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ANGPTL5 for disorders About GeneDecksing
OMIM gene information: 607666
OMIM disorders: --
1  disease for ANGPTL5: About MalaCardskeratoconus
Export disorders for ANGPTL5 gene to outside databases
|
Publications
for ANGPTL5 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ANGPTL5 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ANGPTL5) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification of a novel human angiopoietin-like gene expressed mainly in heart. (PubMed id 12624729)1, 2, 3, 9 Zeng L.... Mao Y. (2003)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
- Human CD34+ CD133+ hematopoietic stem cells cultured with growth factors including Angptl5 efficiently engraft adult NOD-SCID Il2rI^- /- (NSG) mice. (PubMed id 21559522)1 Drake A.C....Chen J. (2011)
- Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)2 Taylor T.D....Sakaki Y. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Angiopoietin-like 5 and IGFBP2 stimulate ex vivo expansion of human cord blood hematopoietic stem cells as assayed by NOD/SCID transplantation. (PubMed id 18202223)9 Zhang C.C....Lodish H.F. (2008)
- Impacts of angiopoietin-like proteins on lipoprotein metabolism and cardiovascular events. (PubMed id 19851103)9 Miida T. and Hirayama S. (2010)
- Rare loss-of-function mutations in ANGPTL family members contribute to plasma triglyceride levels in humans. (PubMed id 19075393)9 Romeo S....Cohen J.C. (2009)
|
External Searches for ANGPTL5 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ANGPTL5 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ANGPTL5 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ANGPTL5 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ANGPTL5 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ANGPTL5 gene:
Search GeneIP for patents involving ANGPTL5
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ANGPTL5 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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