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Aliases for ANGPTL4 Gene

Aliases for ANGPTL4 Gene

  • Angiopoietin-Like 4 2 3
  • Hepatic Fibrinogen/Angiopoietin-Related Protein 2 3 4
  • HFARP 3 4 6
  • PGAR 3 4 6
  • Peroxisome Proliferator-Activated Receptor (PPAR) Gamma Induced Angiopoietin-Related Protein 2 3
  • Hepatic Angiopoietin-Related Protein 2 3
  • PPARG Angiopoietin Related Protein 2 3
  • Fasting-Induced Adipose Factor 2 3
  • Angiopoietin-Related Protein 4 2 3
  • Arp4 3 4
  • FIAF 3 6
  • Angiopoietin-Like Protein 4 4
  • ANGPTL2 3
  • UNQ171 3
  • Pp1158 3
  • TGQTL 3
  • HARP 3
  • NL2 3

External Ids for ANGPTL4 Gene

Previous GeneCards Identifiers for ANGPTL4 Gene

  • GC19P008372
  • GC19P008643
  • GC19P008324
  • GC19P008335
  • GC19P008429
  • GC19P008082

Summaries for ANGPTL4 Gene

Entrez Gene Summary for ANGPTL4 Gene

  • This gene encodes a glycosylated, secreted protein containing a C-terminal fibrinogen domain. The encoded protein is induced by peroxisome proliferation activators and functions as a serum hormone that regulates glucose homeostasis, lipid metabolism, and insulin sensitivity. This protein can also act as an apoptosis survival factor for vascular endothelial cells and can prevent metastasis by inhibiting vascular growth and tumor cell invasion. The C-terminal domain may be proteolytically-cleaved from the full-length secreted protein. Decreased expression of this gene has been associated with type 2 diabetes. Alternative splicing results in multiple transcript variants. This gene was previously referred to as ANGPTL2 but has been renamed ANGPTL4. [provided by RefSeq, Sep 2013]

GeneCards Summary for ANGPTL4 Gene

ANGPTL4 (Angiopoietin-Like 4) is a Protein Coding gene. Diseases associated with ANGPTL4 include plasma triglyceride level qtl, low and tongue squamous cell carcinoma. Among its related pathways are L1CAM interactions and Metabolism. GO annotations related to this gene include enzyme inhibitor activity. An important paralog of this gene is TNC.

UniProtKB/Swiss-Prot for ANGPTL4 Gene

  • Protein with hypoxia-induced expression in endothelial cells. May act as a regulator of angiogenesis and modulate tumorigenesis. Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. May exert a protective function on endothelial cells through an endocrine action. It is directly involved in regulating glucose homeostasis, lipid metabolism, and insulin sensitivity. In response to hypoxia, the unprocessed form of the protein accumulates in the subendothelial extracellular matrix (ECM). The matrix-associated and immobilized unprocessed form limits the formation of actin stress fibers and focal contacts in the adhering endothelial cells and inhibits their adhesion. It also decreases motility of endothelial cells and inhibits the sprouting and tube formation (By similarity).

Gene Wiki entry for ANGPTL4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANGPTL4 Gene

Genomics for ANGPTL4 Gene

Regulatory Elements for ANGPTL4 Gene

Genomic Location for ANGPTL4 Gene

Start:
8,363,289 bp from pter
End:
8,374,375 bp from pter
Size:
11,087 bases
Orientation:
Plus strand

Genomic View for ANGPTL4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ANGPTL4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANGPTL4 Gene

Proteins for ANGPTL4 Gene

  • Protein details for ANGPTL4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BY76-ANGL4_HUMAN
    Recommended name:
    Angiopoietin-related protein 4
    Protein Accession:
    Q9BY76
    Secondary Accessions:
    • A8MY84
    • B4E089
    • D6W670
    • F5H0I2
    • Q53HQ6
    • Q53HU1
    • Q6UXN0
    • Q9HBV4
    • Q9NZU4
    • Q9Y5B3

    Protein attributes for ANGPTL4 Gene

    Size:
    406 amino acids
    Molecular mass:
    45214 Da
    Quaternary structure:
    • Homooligomer. The homooligomer undergoes proteolytic processing to release its carboxyl fibrinogen-like domain, which circulates as a monomer. The homooligomer unprocessed form is able to interact with the extracellular matrix (By similarity).
    SequenceCaution:
    • Sequence=AAQ88642.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ANGPTL4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ANGPTL4 Gene

Proteomics data for ANGPTL4 Gene at MOPED

Post-translational modifications for ANGPTL4 Gene

Other Protein References for ANGPTL4 Gene

No data available for DME Specific Peptides for ANGPTL4 Gene

Domains for ANGPTL4 Gene

Gene Families for ANGPTL4 Gene

HGNC:
  • FIBC :Fibrinogen C domain containing

Suggested Antigen Peptide Sequences for ANGPTL4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BY76

UniProtKB/Swiss-Prot:

ANGL4_HUMAN :
  • Q9BY76
Domain:
  • Contains 1 fibrinogen C-terminal domain.
genes like me logo Genes that share domains with ANGPTL4: view

Function for ANGPTL4 Gene

Molecular function for ANGPTL4 Gene

UniProtKB/Swiss-Prot Function: Protein with hypoxia-induced expression in endothelial cells. May act as a regulator of angiogenesis and modulate tumorigenesis. Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. May exert a protective function on endothelial cells through an endocrine action. It is directly involved in regulating glucose homeostasis, lipid metabolism, and insulin sensitivity. In response to hypoxia, the unprocessed form of the protein accumulates in the subendothelial extracellular matrix (ECM). The matrix-associated and immobilized unprocessed form limits the formation of actin stress fibers and focal contacts in the adhering endothelial cells and inhibits their adhesion. It also decreases motility of endothelial cells and inhibits the sprouting and tube formation (By similarity).

Gene Ontology (GO) - Molecular Function for ANGPTL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004857 enzyme inhibitor activity ISS --
GO:0005515 protein binding IPI 21397862
genes like me logo Genes that share ontologies with ANGPTL4: view
genes like me logo Genes that share phenotypes with ANGPTL4: view

Animal Models for ANGPTL4 Gene

MGI Knock Outs for ANGPTL4:

miRNA for ANGPTL4 Gene

miRTarBase miRNAs that target ANGPTL4

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for ANGPTL4 Gene

Localization for ANGPTL4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ANGPTL4 Gene

Secreted. Secreted, extracellular space, extracellular matrix. Note=The unprocessed form interacts with the extracellular matrix. This may constitute a dynamic reservoir, a regulatory mechanism of the bioavailability of ANGPTL4 (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ANGPTL4 Gene COMPARTMENTS Subcellular localization image for ANGPTL4 gene
Compartment Confidence
extracellular 5
peroxisome 2
cytosol 1
endoplasmic reticulum 1
nucleus 1

Gene Ontology (GO) - Cellular Components for ANGPTL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005578 proteinaceous extracellular matrix IEA --
GO:0005615 extracellular space IDA 10698685
GO:0072562 blood microparticle IDA 22516433
genes like me logo Genes that share ontologies with ANGPTL4: view

Pathways for ANGPTL4 Gene

genes like me logo Genes that share pathways with ANGPTL4: view

Pathways by source for ANGPTL4 Gene

Gene Ontology (GO) - Biological Process for ANGPTL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IEA --
GO:0001666 response to hypoxia NAS 12707035
GO:0030154 cell differentiation IEA --
GO:0043066 negative regulation of apoptotic process IDA 10698685
GO:0044255 cellular lipid metabolic process TAS --
genes like me logo Genes that share ontologies with ANGPTL4: view

Compounds for ANGPTL4 Gene

(9) Novoseek inferred chemical compound relationships for ANGPTL4 Gene

Compound -log(P) Hits PubMed IDs
pioglitazone 55.9 1
lipid 45.9 13
11beta-hydroxysteroid 38.8 2
glucose 35.8 9
fatty acid 20.3 3
genes like me logo Genes that share compounds with ANGPTL4: view

Transcripts for ANGPTL4 Gene

Unigene Clusters for ANGPTL4 Gene

Angiopoietin-like 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ANGPTL4 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9
SP1: -
SP2: -
SP3: - -
SP4: -

Relevant External Links for ANGPTL4 Gene

GeneLoc Exon Structure for
ANGPTL4
ECgene alternative splicing isoforms for
ANGPTL4

Expression for ANGPTL4 Gene

mRNA expression in normal human tissues for ANGPTL4 Gene

mRNA differential expression in normal tissues according to GTEx for ANGPTL4 Gene

This gene is overexpressed in Adipose - Subcutaneous (5.1), Liver (4.8), and Adipose - Visceral (Omentum) (4.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ANGPTL4 Gene

SOURCE GeneReport for Unigene cluster for ANGPTL4 Gene Hs.9613

mRNA Expression by UniProt/SwissProt for ANGPTL4 Gene

Q9BY76-ANGL4_HUMAN
Tissue specificity: Expressed at high levels in the placenta, heart, liver, muscle, pancreas and lung but expressed poorly in the brain and kidney.
genes like me logo Genes that share expressions with ANGPTL4: view

Orthologs for ANGPTL4 Gene

This gene was present in the common ancestor of animals.

Orthologs for ANGPTL4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ANGPTL4 35
  • 99.12 (n)
  • 99.01 (a)
ANGPTL4 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ANGPTL4 35
  • 83.25 (n)
  • 80.1 (a)
ANGPTL4 36
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ANGPTL4 35
  • 82.7 (n)
  • 79.85 (a)
ANGPTL4 36
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Angptl4 35
  • 77.7 (n)
  • 76.79 (a)
Angptl4 16
Angptl4 36
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ANGPTL4 36
  • 59 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Angptl4 35
  • 77.12 (n)
  • 76.79 (a)
chicken
(Gallus gallus)
Aves ANGPTL4 35
  • 58.66 (n)
  • 49.17 (a)
ANGPTL4 36
  • 41 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.10669 35
tropical clawed frog
(Silurana tropicalis)
Amphibia angptl4 35
  • 51.86 (n)
  • 44.68 (a)
zebrafish
(Danio rerio)
Actinopterygii angptl4 35
  • 55.06 (n)
  • 48.88 (a)
angptl4 36
  • 34 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG7668 36
  • 21 (a)
OneToMany
sca 37
  • 31 (a)
worm
(Caenorhabditis elegans)
Secernentea T15B7.1 36
  • 22 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 42 (a)
OneToMany
Species with no ortholog for ANGPTL4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ANGPTL4 Gene

ENSEMBL:
Gene Tree for ANGPTL4 (if available)
TreeFam:
Gene Tree for ANGPTL4 (if available)

Paralogs for ANGPTL4 Gene

Paralogs for ANGPTL4 Gene

genes like me logo Genes that share paralogs with ANGPTL4: view

Variants for ANGPTL4 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for ANGPTL4 Gene

Q9BY76-ANGL4_HUMAN
Genetic variations in ANGPTL4 are associated with low plasma triglyceride levels and define the plasma triglyceride level quantitative trait locus (TGQTL) [MIM:615881].

Sequence variations from dbSNP and Humsavar for ANGPTL4 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs1044250 - 8,371,280(+) CATCA(C/T)GGGGG reference, missense, intron-variant
rs2010871 -- 8,363,686(+) GGGTT(C/T)AAGCG upstream-variant-2KB
rs2278236 -- 8,366,697(-) ACCCC(C/T)TCCTC intron-variant
rs3183953 -- 8,373,745(+) CTCAA(C/T)GGCCA reference, synonymous-codon, intron-variant
rs3210978 -- 8,366,065(+) GCCAG(A/T)TTGGC splice-donor-variant

Structural Variations from Database of Genomic Variants (DGV) for ANGPTL4 Gene

Variant ID Type Subtype PubMed ID
dgv3719n71 CNV Loss 21882294
nsv911001 CNV Loss 21882294
nsv911003 CNV Loss 21882294
nsv911004 CNV Loss 21882294

Relevant External Links for ANGPTL4 Gene

HapMap Linkage Disequilibrium report
ANGPTL4
Human Gene Mutation Database (HGMD)
ANGPTL4

Disorders for ANGPTL4 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for ANGPTL4 Gene including...

Search for ANGPTL4 Gene in MalaCards »

(9) Novoseek inferred disease relationships for ANGPTL4 Gene

Disease -log(P) Hits PubMed IDs
obesity 44.6 4
insulin sensitivity 37 1
insulin resistance 24.4 3
tumors 10.9 13
cancer 4.05 1

Relevant External Links for ANGPTL4

Genetic Association Database (GAD)
ANGPTL4
Human Genome Epidemiology (HuGE) Navigator
ANGPTL4
genes like me logo Genes that share disorders with ANGPTL4: view

No data available for UniProtKB/Swiss-Prot for ANGPTL4 Gene

Publications for ANGPTL4 Gene

  1. Hepatic expression, synthesis and secretion of a novel fibrinogen/angiopoietin-related protein that prevents endothelial-cell apoptosis. (PMID: 10698685) Kim I. … Koh G.Y. (Biochem. J. 2000) 2 3 4 23
  2. Peroxisome proliferator-activated receptor gamma target gene encoding a novel angiopoietin-related protein associated with adipose differentiation. (PMID: 10866690) Yoon J.C. … Spiegelman B.M. (Mol. Cell. Biol. 2000) 2 3 4 23
  3. Cloning of a novel gene, ANGPTL4 and the functional study in angiogenesis. (PMID: 11953136) Zhu H. … Gu J. (Zhonghua Yi Xue Za Zhi 2002) 3 4 23
  4. Angiopoietin-like 4 is a proangiogenic factor produced during ischemia and in conventional renal cell carcinoma. (PMID: 12707035) Le Jan S. … Germain S. (Am. J. Pathol. 2003) 3 23
  5. Oligomerization and regulated proteolytic processing of angiopoietin-like protein 4. (PMID: 14570927) Ge H. … Li C. (J. Biol. Chem. 2004) 3 23

Products for ANGPTL4 Gene

Sources for ANGPTL4 Gene

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