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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ANGPTL4 Gene

protein-coding   GIFtS: 64
GCID: GC19P008429

angiopoietin-like 4
 Explore 37 diseases affiliated with
ANGPTL4 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ANGPTL4    

Aliases
for ANGPTL4 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Angiopoietin-Like 41 2     Hepatic Fibrinogen/Angiopoietin-Related Protein2 3
HFARP1 2 3 5     ANGPTL22
PGAR1 2 3 5     Angiopoietin-Related Protein 42
ARP41 2 3     Fasting-Induced Adipose Factor2
FIAF1 2 5     Hepatic Angiopoietin-Related Protein2
NL21 2     Peroxisome Proliferator-Activated Receptor (PPAR) Gamma Induced
Angiopoietin-Related Protein2
Pp11581     PPARG Angiopoietin Related Protein2
Angiopoietin-Like Protein 42 3     

External Ids:    HGNC: 160391   Entrez Gene: 511292   Ensembl: ENSG000001677727   OMIM: 6059105   UniProtKB: Q9BY763   

Export aliases for ANGPTL4 gene to outside databases

Previous GC identifers: GC19P008372 GC19P008643 GC19P008324 GC19P008335 GC19P008082


Summaries
for ANGPTL4 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for ANGPTL4:
This gene is a member of the angiopoietin/angiopoietin-like gene family and encodes a glycosylated, secreted protein
with a fibrinogen C-terminal domain. This gene is induced under hypoxic conditions in endothelial cells and is the
target of peroxisome proliferation activators. The encoded protein is a serum hormone directly involved in regulating
glucose homeostasis, lipid metabolism, and insulin sensitivity and also acts as an apoptosis survival factor for
vascular endothelial cells. The encoded protein may play a role in several cancers and it also has been shown to
prevent the metastatic process by inhibiting vascular activity as well as tumor cell motility and invasiveness.
Decreased expression of this protein has been associated with type 2 diabetes. Alternatively spliced transcript
variants encoding different isoforms have been described. This gene was previously referred to as ANGPTL2 but has been
renamed ANGPTL4. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: ANGL4_HUMAN, Q9BY76
Function: Protein with hypoxia-induced expression in endothelial cells. May act as a regulator of angiogenesis and
modulate tumorigenesis. Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces
vascular leakage. May exert a protective function on endothelial cells through an endocrine action. It is directly
involved in regulating glucose homeostasis, lipid metabolism, and insulin sensitivity. In response to hypoxia, the
unprocessed form of the protein accumulates in the subendothelial extracellular matrix (ECM). The matrix-associated
and immobilized unprocessed form limits the formation of actin stress fibers and focal contacts in the adhering
endothelial cells and inhibits their adhesion. It also decreases motility of endothelial cells and inhibits the
sprouting and tube formation (By similarity)

Gene Wiki entry for ANGPTL4


Genomic Views
for ANGPTL4 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.1  NT_077812.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ANGPTL4 gene promoter:
         PPAR-gamma1   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): ANGPTL4 promoter sequence
   Search SABiosciences Chromatin IP Primers for ANGPTL4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ANGPTL4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3   Ensembl cytogenetic band:  19p13.2   HGNC cytogenetic band: 19p13.3

ANGPTL4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ANGPTL4 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P008429:  view genomic region     (about GC identifiers)

Start:
 8,429,011 bp from pter      End:
 8,439,257 bp from pter
Size:
 10,247 bases      Orientation:
 plus strand

Proteins
for ANGPTL4 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ANGL4_HUMAN, Q9BY76 (See protein sequence)
Recommended Name: Angiopoietin-related protein 4 precursor  
Size: 406 amino acids; 45214 Da
Subunit: Homooligomer. The homooligomer undergoes proteolytic processing to release its carboxyl fibrinogen-like
domain, which circulates as a monomer. The homooligomer unprocessed form is able to interact with the extracellular
matrix (By similarity)
Subcellular location: Secreted. Secreted, extracellular space, extracellular matrix (By similarity). Note=The
unprocessed form interacts with the extracellular matrix. This may constitute a dynamic reservoir, a regulatory
mechanism of the bioavailability of ANGPTL4 (By similarity)
Sequence caution: Sequence=AAQ88642.1; Type=Erroneous initiation;
Secondary accessions: D6W670 Q53HQ6 Q53HU1 Q6UXN0 Q9HBV4 Q9NZU4 Q9Y5B3

Explore the universe of human proteins at neXtProt for ANGPTL4: NX_Q9BY76

Post-translational modifications:

  • N-glycosylated1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9BY76

    • ANGPTL4 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001034756.1  NP_647475.1  

    ENSEMBL proteins: 
     ENSP00000301455   ENSP00000377534   ENSP00000439833  
    Reactome Protein details: Q9BY76
    Human Recombinant Protein Products: 
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    R&D Systems Recombinant & Natural Proteins for ANGPTL4 (Angiopoietin-like Protein 4/ANGPTL4)
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    OriGene Protein Over-expression Lysate: ANGPTL4
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    Novus Biologicals ANGPTL4 Proteins
    Novus Biologicals ANGPTL4 Lysates
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for ANGPTL4
    Uscn Proteins for ANGPTL4

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005578proteinaceous extracellular matrix IEA--
    GO:0005615extracellular space IDA10698685


    ANGPTL4 for ontologies           About GeneDecksing



    ANGPTL4 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of ANGPTL4
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    Abcam antibodies for ANGPTL4 
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    ThermoFisher Antibody for ANGPTL4

    Assay Products for ANGPTL4: 
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    Uscn ELISAs and CLIAs for ANGPTL4

    Protein Domains /
    Families
    for ANGPTL4 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ANGPTL4 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR020837 Fibrinogen_CS
     IPR014715 Fibrinogen_a/b/g_C_2
     IPR002181 Fibrinogen_a/b/g_C_dom
     IPR014716 Fibrinogen_a/b/g_C_1

    Graphical View of Domain Structure for InterPro Entry Q9BY76

    ProtoNet protein and cluster: Q9BY76

    1 Blocks protein family: IPB002181 Fibrinogen

    UniProtKB/Swiss-Prot: ANGL4_HUMAN, Q9BY76
    Similarity: Contains 1 fibrinogen C-terminal domain


    Function
    for ANGPTL4 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: ANGL4_HUMAN, Q9BY76
    Function: Protein with hypoxia-induced expression in endothelial cells. May act as a regulator of angiogenesis and
    modulate tumorigenesis. Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces
    vascular leakage. May exert a protective function on endothelial cells through an endocrine action. It is directly
    involved in regulating glucose homeostasis, lipid metabolism, and insulin sensitivity. In response to hypoxia, the
    unprocessed form of the protein accumulates in the subendothelial extracellular matrix (ECM). The matrix-associated
    and immobilized unprocessed form limits the formation of actin stress fibers and focal contacts in the adhering
    endothelial cells and inhibits their adhesion. It also decreases motility of endothelial cells and inhibits the
    sprouting and tube formation (By similarity)

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ANGPTL4
    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate ANGPTL4 (see all 9):
    hsa-miR-4303 hsa-miR-3164 hsa-miR-3140-3p hsa-miR-642a hsa-miR-3136-5p hsa-miR-3065-3p hsa-miR-134 hsa-miR-942
    SwitchGear 3'UTR luciferase reporter plasmid: ANGPTL4 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ANGPTL4 (see all 7)
    OriGene shRNA RFP: ANGPTL4
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ANGPTL4

    Gene Editing
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    Clone
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    Sino Biological Human cDNA Clone for ANGPTL4
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ANGPTL4 

    Cell Line
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    LifeMap BioReagents: cell line associated with ANGPTL4: PureStem ES-210, Ecto-ntu Progenitor

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANGPTL4

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004857enzyme inhibitor activity ISS--
    GO:0005102receptor binding IEA--
    GO:0005515protein binding IPI--


    ANGPTL4 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for ANGPTL4:
     Decreased viability of wild-ty  Decreased viability with pacli 

    Animal Models:
         Mouse knock-outs for ANGPTL4: Angptl4tm1Akos Angptl4tm1Lex Angptl4tm1Jig
         8 MGI mutant phenotypes (inferred from 6 alleles) (MGI details for Angptl4):
     adipose tissue  cardiovascular system  digestive/alimentary  growth/size  homeostasis/metabolism 
     immune system  mortality/aging  vision/eye 

    ANGPTL4 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for ANGPTL4 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
    		Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)1.00
    		Fatty acid, triacylglycerol, and ketone body metabolism0.52
    		PPARA Activates Gene Expression0.74
    2Metabolism
    		Metabolism1.00
    		Metabolism of lipids and lipoproteins0.34
    3Expression of ANGPTL4
    		Expression of ANGPTL41.00
    4Transcriptional Regulation of White Adipocyte Differentiation
    		Transcriptional Regulation of White Adipocyte Differentiation1.00
    5Selected targets of GCR-alpha
    		Selected targets of GCR-alpha1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for ANGPTL4
        Selected targets of GCR-alpha


    5/8        Reactome Pathways for ANGPTL4 (see all 8)
        Developmental Biology
    Transcriptional Regulation of White Adipocyte Differentiation
    Metabolism
    Fatty acid, triacylglycerol, and ketone body metabolism
    Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)


    1         Kegg Pathway  (Kegg details for ANGPTL4):
        PPAR signaling pathway


    ANGPTL4 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ANGPTL4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/55 Interacting proteins for ANGPTL4 (Q9BY761 ENSP000003014554) via UniProtKB, MINT, STRING, and/or I2D (see all 55)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ITGB1P055561, ENSP000003640944EBI-2968146,EBI-4289597 STRING: ENSP00000364094
    ITGB5P180841, ENSP000002961814EBI-2968146,EBI-1223434 STRING: ENSP00000296181
    CHD9ENSP000003815224STRING: ENSP00000381522
    CREBBPENSP000002623674STRING: ENSP00000262367
    EP300ENSP000002632534STRING: ENSP00000263253
    About this table

    Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis IEA--
    GO:0001666response to hypoxia NAS12707035
    GO:0007165signal transduction IEA--
    GO:0030154cell differentiation IEA--
    GO:0043066negative regulation of apoptotic process IDA10698685


    ANGPTL4 for ontologies           About GeneDecksing



    Drugs & Compounds
    for ANGPTL4 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ANGPTL4 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ANGPTL4
    9 Novoseek chemical compound relationships for ANGPTL4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pioglitazone 55.9 2 15220243 (1)
    lipid 45.9 20 17609370 (3), 15837923 (3), 16272564 (2), 16081640 (1) (see all 8)
    11beta-hydroxysteroid 38.8 3 17030965 (1), 15220243 (1)
    glucose 35.8 13 15837923 (7), 16272564 (1), 10866690 (1)
    fatty acid 20.3 3 16272564 (1), 19935699 (1), 17210919 (1)
    fibrinogen 15.3 4 14570927 (3), 10698685 (1)
    glycerol 8.57 3 16272564 (2)
    cysteine 6.15 2 19028676 (1), 15292369 (1)
    cholesterol 0 2 16272564 (1), 17609370 (1)

    Search CenterWatch for drugs/clinical trials and news about ANGPTL4 / ANGL4 

    Transcripts
    for ANGPTL4 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ANGPTL4 gene (3 alternative transcripts): 
    NM_001039667.1  NM_139314.1  NM_016109.2  

    Unigene Cluster for ANGPTL4:

    Angiopoietin-like 4
    Hs.9613  [show with all ESTs]
    Unigene Representative Sequence: NM_139314
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000301455(uc002mjq.1 uc010xkc.1) ENST00000393962(uc002mjr.1)
    ENST00000541807

    miRNA
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    hsa-miR-4303 hsa-miR-3164 hsa-miR-3140-3p hsa-miR-642a hsa-miR-3136-5p hsa-miR-3065-3p hsa-miR-134 hsa-miR-942
    SwitchGear 3'UTR luciferase reporter plasmid: ANGPTL4 3' UTR sequence
    Inhib. RNA
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    Clone
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    Additional cDNA sequence: 

    AB056477.1 AF169312.1 AF202636.1 AK222489.1 AK222524.1 AK303269.1 AY358275.1 BC023647.2 

    12 DOTS entries:

    DT.100037035  DT.443291  DT.97858809  DT.92427844  DT.121477749  DT.100801046  DT.100801049  DT.100801044 
    DT.92427846  DT.95227603  DT.121477721  DT.121477733 

    24/237 AceView cDNA sequences (see all 237):

    CR615250 AI969573 AA651623 AI597787 AI312943 AW572561 BQ927396 CR609072 
    BM972049 AI139584 BE045761 BM720059 AY358275 BM677698 BC023647 CA487585 
    NM_016109 AI432962 BU739876 CR594816 BU543829 BQ013128 CR615268 NM_139314 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for ANGPTL4    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9
    SP1:                                            -                           
    SP2:                                            -                           
    SP3:        -     -                                                         
    SP4:                                -                                       


    ECgene alternative splicing isoforms for ANGPTL4

    Expression
    for ANGPTL4 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ANGPTL4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GTGCTGGTGC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    ANGPTL4 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BrainMeningesBrain
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 2 LifeMap Cells 
    NameCategory
    Sox17-GFP genetically modified stem cells (Embryonic Stem Cell)Early Embryo, Inner Cell Mass
    HyStem+BMP4-induced E15 cells (HyStem+BMP4 inductio...)Adipose, Bone, Cartilage

    See ANGPTL4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ANGPTL4

    SOURCE GeneReport for Unigene cluster: Hs.9613

    UniProtKB/Swiss-Prot: ANGL4_HUMAN, Q9BY76
    Tissue specificity: Expressed at high levels in the placenta, heart, liver, muscle, pancreas and lung but expressed
    poorly in the brain and kidney

        SABiosciences Expression via Pathway-Focused PCR Arrays including ANGPTL4 (see all 7): 
              Nephrotoxicity in human mouse rat
              Angiogenic Growth Factors in human mouse rat
              WNT Signaling Targets in human mouse rat
              Neurotoxicity in human mouse rat
              Hypoxia Signaling Pathway in human mouse rat

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    Orthologs
    for ANGPTL4 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for ANGPTL4 gene from 3/10 species (see all 10)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves ANGPTL41 angiopoietin-like 4 58.84(n)
    49.17(a)    		   769087  XM_001232283.2  XP_001232284.2 
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.106692 Xenopus laevis transcribed sequence with weak similarity more 76.1(n)    48015723 
    zebrafish
    (Danio rerio)    		 Actinopterygii angptl41 angiopoietin-like 4 54.81(n)
    49.58(a)    		   492647  XM_686956.4  XP_692048.2 


    ENSEMBL Gene Tree for ANGPTL4 (if available)
    TreeFam Gene Tree for ANGPTL4 (if available) 

    Paralogs
    for ANGPTL4 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ANGPTL4 gene
    FGL22  ANGPT42  FGA2  FGG2  ANGPTL62  ANGPTL22  ANGPT12  ANGPTL32  
    ANGPTL12  ANGPTL72  FGB2  ANGPT22  FGL12  
    14 SIMAP similar genes for ANGPTL4 using alignment to 8 protein entries:     ANGL4_HUMAN (see all proteins):
    ANGPTL2    FGG    ANGPT1    ANGPTL3    ANGPTL7    FCN1
    FCN2    FCN3    MFAP4    FGL1    FIBCD1    LFIRE1
    TNC    FGB

    ANGPTL4 for paralogs           About GeneDecksing



    Genomic Variants
    for ANGPTL4 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/240 NCBI SNPs in ANGPTL4 are shown (see all 240)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 19 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1168430641,2
    		C,F,other8610282(+) GGGACG/AAGATG 4 /K /E mis11Minor allele frequency- A:0.03NA 120
    rs774120701,2
    		F,--8082097(+) TTTCAT/CTTTGA 2 -- us2k11Minor allele frequency- C:0.02WA 118
    rs1128221121,2
    		--8082442(+) AGGAAA/GGCCTG 2 -- us2k12Minor allele frequency- G:0.33CSA 3
    rs40763171,2
    		C,F,A,H,--8082610(-) GGTGCG/CGAGTG 2 -- us2k110Minor allele frequency- C:0.21NS EA MN WA NA 2972
    rs351379941,2
    		C,--8082677(+) TCACAC/G/TGACTG 4 -- ut513CSA NA 1067
    rs115446121,2
    		C,--8082703(-) AGAAGC/TCGCTG 2 -- ut51 ese32Minor allele frequency- T:0.10CSA WA 119
    rs104190211,2
    		C,F,--8083245(+) CTGGGC/TTTCCC 2 -- int11Minor allele frequency- T:0.02WA 118
    rs104053401,2
    		C,--8083682(+) taaaaT/Caaaaa 2 -- int13Minor allele frequency- C:0.09CSA WA 1066
    rs610970601,2
    		C,F,--8084294(+) GGCGAG/AAGAAC 2 -- int12Minor allele frequency- A:0.50WA CSA 4
    rs104074661,2
    		C,F,H,--8085166(+) AGAACC/TTTCTA 2 -- int19Minor allele frequency- T:0.01NS EA NA WA 956

    HapMap Linkage Disequilibrium report for ANGPTL4 (8429011 - 8439257 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for ANGPTL4: --
    Human Gene Mutation Database (HGMD): ANGPTL4

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    Disorders / Diseases
    for ANGPTL4 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ANGPTL4 for disorders           About GeneDecksing

    OMIM gene information: 605910    OMIM disorders: --

    20/37 diseases for ANGPTL4 (see all 37):    About MalaCards
    reduced triglycerides    hepatitis    traumatic brain injury    clear cell renal cell carcinoma
    type 2 diabetes mellitus    arteriovenous malformation    brain injury    insulin resistance
    renal cell carcinoma    coronary heart disease    diabetes mellitus    squamous cell carcinoma
    lipodystrophy    bladder carcinoma    hyperlipidemia    kidney disease
    ischemia    obesity    homocysteine    hepatocellular carcinoma

    9 Novoseek disease relationships for ANGPTL4 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    obesity 44.6 5 17210919 (2), 17030965 (1), 10866690 (1)
    insulin sensitivity 37 1 15837923 (1)
    insulin resistance 24.4 4 15326464 (1), 16870142 (1), 15837923 (1)
    tumors 10.9 15 12707035 (4), 20454689 (4), 18394990 (2), 17030965 (1) (see all 6)
    cancer 4.05 1 18394990 (1)
    cardiovascular diseases 0 2 19851103 (1)
    ischemia 0 2 12707035 (2)
    necrosis 0 4 17030965 (1), 15220243 (1), 15949695 (1)
    metastasis 0 4 20454689 (1), 18394990 (1), 19364815 (1), 19775228 (1)

    Human Genome Epidemiology (HuGE) Navigator: ANGPTL4 (14 documents)

    Export disorders for ANGPTL4 gene to outside databases

    Publications
    for ANGPTL4 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ANGPTL4 gene, integrated from 9 sources (see all 132):
    (articles sorted by number of sources associating them with ANGPTL4)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Hepatic expression, synthesis and secretion of a novel fibrinogen/angiopoietin-related protein that prevents endothelial-cell apoptosis. (PubMed id 10698685)1, 2, 3, 9 Kim I....Koh G.Y. (2000)
    2. Peroxisome proliferator-activated receptor gamma target gene encoding a novel angiopoietin-related protein associated with adipose differentiation. (PubMed id 10866690)1, 2, 3, 9 Yoon J.C.... Spiegelman B.M. (2000)
    3. Cloning of a novel gene, ANGPTL4 and the functional study in angiogenesis. (PubMed id 11953136)1, 2, 9 Zhu H.... Gu J. (2002)
    4. Population-based resequencing of ANGPTL4 uncovers variations that reduce triglycerides and increase HDL. (PubMed id 17322881)1, 2 Romeo S.... Cohen J.C. (2007)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Inhibition of angiogenesis and vascular leakiness by angiopoietin- related protein 4. (PubMed id 14583458)1, 2 Ito Y.... Suda T. (2003)
    7. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    8. Expression and function of hepatocellular carcinoma-related gene pp1158. (PubMed id 12015030)1, 2 Zhu H.... Gu J. (2002)
    9. The direct peroxisome proliferator-activated receptor target fasting-induced adipose factor (FIAF/PGAR/ANGPTL4) is present in blood plasma as a truncated protein that is increased by fenofibrate treatment. (PubMed id 15190076)1, 9 Mandard S....Kersten S. (2004)
    10. Muscle-derived angiopoietin-like protein 4 is induced by fatty acids via peroxisome proliferator-activated receptor (PPAR)-delta and is of metabolic relevance in humans. (PubMed id 19074989)1, 9 Staiger H....HAoring H.U. (2009)

    External Searches for ANGPTL4 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing ANGPTL4 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51129 HGNC: 16039 AceView: ANGPTL4 Ensembl:ENSG00000167772 euGenes: HUgn51129
    ECgene: ANGPTL4 Kegg: 51129 H-InvDB: ANGPTL4

    Other Databases showing ANGPTL4 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ANGPTL4 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ANGPTL4 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for ANGPTL4 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ANGPTL4 gene:
    Search GeneIP for patents involving ANGPTL4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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