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ANGPTL4 Gene

protein-coding   GIFtS: 65
GCID: GC19P008429

Angiopoietin-Like 4

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Angiopoietin-Like 41 2     ARP42 3
Hepatic Fibrinogen/Angiopoietin-Related Protein1 2 3     FIAF2 5
HFARP2 3 5     ANGPTL22
PGAR2 3 5     HARP2
Angiopoietin-Related Protein 41 2     NL22
Fasting-Induced Adipose Factor1 2     UNQ1712
Hepatic Angiopoietin-Related Protein1 2     pp11582
Peroxisome Proliferator-Activated Receptor (PPAR) Gamma Induced
Angiopoietin-Related Protein1 2
     Angiopoietin-Like Protein 43
PPARG Angiopoietin Related Protein1 2     

External Ids:    HGNC: 160391   Entrez Gene: 511292   Ensembl: ENSG000001677727   OMIM: 6059105   UniProtKB: Q9BY763   

Export aliases for ANGPTL4 gene to outside databases

Previous GC identifers: GC19P008372 GC19P008643 GC19P008324 GC19P008335 GC19P008082


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ANGPTL4 Gene:
This gene encodes a glycosylated, secreted protein containing a C-terminal fibrinogen domain. The encoded protein
is induced by peroxisome proliferation activators and functions as a serum hormone that regulates glucose
homeostasis, lipid metabolism, and insulin sensitivity. This protein can also act as an apoptosis survival factor
for vascular endothelial cells and can prevent metastasis by inhibiting vascular growth and tumor cell invasion.
The C-terminal domain may be proteolytically-cleaved from the full-length secreted protein. Decreased expression
of this gene has been associated with type 2 diabetes. Alternative splicing results in multiple transcript
variants. This gene was previously referred to as ANGPTL2 but has been renamed ANGPTL4. (provided by RefSeq, Sep
2013)

GeneCards Summary for ANGPTL4 Gene:
ANGPTL4 (angiopoietin-like 4) is a protein-coding gene. Diseases associated with ANGPTL4 include reduced triglycerides, and hepatitis. GO annotations related to this gene include enzyme inhibitor activity. An important paralog of this gene is TNXB.

UniProtKB/Swiss-Prot: ANGL4_HUMAN, Q9BY76
Function: Protein with hypoxia-induced expression in endothelial cells. May act as a regulator of angiogenesis and
modulate tumorigenesis. Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces
vascular leakage. May exert a protective function on endothelial cells through an endocrine action. It is
directly involved in regulating glucose homeostasis, lipid metabolism, and insulin sensitivity. In response to
hypoxia, the unprocessed form of the protein accumulates in the subendothelial extracellular matrix (ECM). The
matrix-associated and immobilized unprocessed form limits the formation of actin stress fibers and focal contacts
in the adhering endothelial cells and inhibits their adhesion. It also decreases motility of endothelial cells
and inhibits the sprouting and tube formation (By similarity)

Gene Wiki entry for ANGPTL4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NT_011295.12  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ANGPTL4 gene promoter:
         PPAR-gamma1   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): ANGPTL4 promoter sequence
   Search Chromatin IP Primers for ANGPTL4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ANGPTL4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3   Ensembl cytogenetic band:  19p13.2   HGNC cytogenetic band: 19p13.3

ANGPTL4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ANGPTL4 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P008429:  view genomic region     (about GC identifiers)

Start:
8,428,173 bp from pter      End:
8,439,257 bp from pter
Size:
11,085 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ANGL4_HUMAN, Q9BY76 (See protein sequence)
Recommended Name: Angiopoietin-related protein 4 precursor  
Size: 406 amino acids; 45214 Da
Subunit: Homooligomer. The homooligomer undergoes proteolytic processing to release its carboxyl fibrinogen-like
domain, which circulates as a monomer. The homooligomer unprocessed form is able to interact with the
extracellular matrix (By similarity)
Sequence caution: Sequence=AAQ88642.1; Type=Erroneous initiation;
Secondary accessions: A8MY84 D6W670 Q53HQ6 Q53HU1 Q6UXN0 Q9HBV4 Q9NZU4 Q9Y5B3
Alternative splicing: 2 isoforms:  Q9BY76-1   Q9BY76-2   (Gene prediction based on EST data)

Explore the universe of human proteins at neXtProt for ANGPTL4: NX_Q9BY76

Explore proteomics data for ANGPTL4 at MOPED

Post-translational modifications: 

  • N-glycosylated1
  • Glycosylation2 at Asn177

  • See ANGPTL4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001034756.1  NP_647475.1  

    ENSEMBL proteins: 
     ENSP00000470307   ENSP00000473090   ENSP00000471345   ENSP00000301455   ENSP00000473025  
     ENSP00000377534   ENSP00000472551   ENSP00000472869   ENSP00000439833  
    Reactome Protein details: Q9BY76

    ANGPTL4 Human Recombinant Protein Products:

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    Enzo Life Sciences proteins for ANGPTL4
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    OriGene Protein Over-expression Lysate for ANGPTL4
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    Novus Biologicals ANGPTL4 Proteins
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    Sino Biological Recombinant Protein for ANGPTL4
    Sino Biological Cell Lysate for ANGPTL4
    ProSpec Recombinant Protein for ANGPTL4
    Cloud-Clone Corp. Proteins for ANGPTL4

    ANGPTL4 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of ANGPTL4
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    OriGene Antibodies for ANGPTL4
    OriGene Custom Antibody Services for ANGPTL4
    Novus Biologicals ANGPTL4 Antibodies
    Abcam antibodies for ANGPTL4
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    ThermoFisher Antibody for ANGPTL4
    LSBio Antibodies in human, mouse, rat for ANGPTL4

    ANGPTL4 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for ANGPTL4
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    Cloud-Clone Corp. ELISAs for ANGPTL4
    Cloud-Clone Corp. CLIAs for ANGPTL4


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    FIBC: Fibrinogen C domain containing

    5 InterPro protein domains:
     IPR014715 Fibrinogen_a/b/g_C_2
     IPR028793 ANGPTL4
     IPR014716 Fibrinogen_a/b/g_C_1
     IPR020837 Fibrinogen_CS
     IPR002181 Fibrinogen_a/b/g_C_dom

    Graphical View of Domain Structure for InterPro Entry Q9BY76

    ProtoNet protein and cluster: Q9BY76

    1 Blocks protein domain: IPB002181 Fibrinogen

    UniProtKB/Swiss-Prot: ANGL4_HUMAN, Q9BY76
    Similarity: Contains 1 fibrinogen C-terminal domain


    ANGPTL4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ANGL4_HUMAN, Q9BY76
    Function: Protein with hypoxia-induced expression in endothelial cells. May act as a regulator of angiogenesis and
    modulate tumorigenesis. Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces
    vascular leakage. May exert a protective function on endothelial cells through an endocrine action. It is
    directly involved in regulating glucose homeostasis, lipid metabolism, and insulin sensitivity. In response to
    hypoxia, the unprocessed form of the protein accumulates in the subendothelial extracellular matrix (ECM). The
    matrix-associated and immobilized unprocessed form limits the formation of actin stress fibers and focal contacts
    in the adhering endothelial cells and inhibits their adhesion. It also decreases motility of endothelial cells
    and inhibits the sprouting and tube formation (By similarity)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004857enzyme inhibitor activity ISS--
    GO:0005515protein binding IPI--
         
    ANGPTL4 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for ANGPTL4:
     Decreased viability of wild-ty  Decreased viability with pacli 

         8 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Angptl4):
     adipose tissue  cardiovascular system  digestive/alimentary  growth/size/body  homeostasis/metabolism 
     immune system  mortality/aging  vision/eye 

    ANGPTL4 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for ANGPTL4: Angptl4tm1Akos Angptl4tm1Lex Angptl4tm1Jig

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ANGPTL4
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ANGPTL4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ANGPTL4
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ANGPTL4

    miRNA
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    miRTarBase miRNAs that target ANGPTL4:
    hsa-mir-1 (MIRT023828), hsa-mir-124-3p (MIRT022740)

    Block miRNA regulation of human, mouse, rat ANGPTL4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ANGPTL4 (see all 9):
    hsa-miR-4303 hsa-miR-3164 hsa-miR-3140-3p hsa-miR-642a hsa-miR-3136-5p hsa-miR-3065-3p hsa-miR-134 hsa-miR-942
    SwitchGear 3'UTR luciferase reporter plasmidANGPTL4 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ANGPTL4
    Predesigned siRNA for gene silencing in human, mouse, rat ANGPTL4

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ANGPTL4

    Clone
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    OriGene clones in human, mouse for ANGPTL4 (see all 12)
    OriGene ORF clones in mouse, rat for ANGPTL4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): ANGPTL4 (NM_001039667)
    Sino Biological Human cDNA Clone for ANGPTL4
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ANGPTL4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ANGPTL4

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for ANGPTL4
    ESI BIO PureStem Progenitor for ANGPTL4: 
    PureStem ES-210, Ecto-ntu Progenitor
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANGPTL4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ANGL4_HUMAN, Q9BY76: Secreted. Secreted, extracellular space, extracellular matrix (By similarity). Note=The
    unprocessed form interacts with the extracellular matrix. This may constitute a dynamic reservoir, a regulatory
    mechanism of the bioavailability of ANGPTL4 (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    peroxisome2
    cytosol1
    endoplasmic reticulum1
    nucleus1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005578proteinaceous extracellular matrix IEA--
    GO:0005615extracellular space IDA10698685
    GO:0072562blood microparticle IDA--

    ANGPTL4 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ANGPTL4 About    
    See pathways by source

    SuperPathContained pathways About
    1Fatty acid, triacylglycerol, and ketone body metabolism
    Fatty acid, triacylglycerol, and ketone body metabolism0.65
    PPARA Activates Gene Expression0.63
    Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)0.65
    Transcriptional Regulation of White Adipocyte Differentiation0.38
    2Metabolism
    Metabolism0.38
    Metabolism of lipids and lipoproteins0.37
    3L1CAM interactions
    Developmental Biology0.63
    4Selected targets of GCR alpha
    Selected targets of GCR alpha
    5PPAR signaling pathway
    PPAR signaling pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    2 Reactome Pathways for ANGPTL4
        Transcriptional regulation of white adipocyte differentiation
    PPARA activates gene expression


    1 Kegg Pathway  (Kegg details for ANGPTL4):
        PPAR signaling pathway


    ANGPTL4 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ANGPTL4 (see all 7): 
              Nephrotoxicity in human mouse rat
              Angiogenic Growth Factors in human mouse rat
              WNT Signaling Targets in human mouse rat
              Neurotoxicity in human mouse rat
              Hypoxia Signaling Pathway in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for ANGPTL4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ANGPTL4 (Q9BY761 ENSP000003014554) via UniProtKB, MINT, STRING, and/or I2D (see all 55)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ITGB1P055561, ENSP000003640944EBI-2968146,EBI-703066 STRING: ENSP00000364094
    ITGB5P180841, ENSP000002961814EBI-2968146,EBI-1223434 STRING: ENSP00000296181
    CHD9ENSP000003815224STRING: ENSP00000381522
    CREBBPENSP000002623674STRING: ENSP00000262367
    EP300ENSP000002632534STRING: ENSP00000263253
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis IEA--
    GO:0001666response to hypoxia NAS12707035
    GO:0030154cell differentiation IEA--
    GO:0043066negative regulation of apoptotic process IDA10698685
    GO:0044255cellular lipid metabolic process TAS--

    ANGPTL4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ANGPTL4 (ANGL4)

    9 Novoseek inferred chemical compound relationships for ANGPTL4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pioglitazone 55.9 2 15220243 (1)
    lipid 45.9 20 17609370 (3), 15837923 (3), 16272564 (2), 16081640 (1) (see all 8)
    11beta-hydroxysteroid 38.8 3 17030965 (1), 15220243 (1)
    glucose 35.8 13 15837923 (7), 16272564 (1), 10866690 (1)
    fatty acid 20.3 3 16272564 (1), 19935699 (1), 17210919 (1)
    fibrinogen 15.3 4 14570927 (3), 10698685 (1)
    glycerol 8.57 3 16272564 (2)
    cysteine 6.15 2 19028676 (1), 15292369 (1)
    cholesterol 0 2 16272564 (1), 17609370 (1)



    ANGPTL4 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ANGPTL4 gene (3 alternative transcripts): 
    NM_001039667.2  NM_139314.2  NM_016109.2  

    Unigene Cluster for ANGPTL4:

    Angiopoietin-like 4
    Hs.9613  [show with all ESTs]
    Unigene Representative Sequence: NM_139314
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000601886 ENST00000599192 ENST00000597137 ENST00000601770 ENST00000301455(uc002mjq.1 uc010xkc.1)
    ENST00000595079 ENST00000598255 ENST00000594348 ENST00000393962(uc002mjr.1)
    ENST00000593998 ENST00000594875 ENST00000541807
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate ANGPTL4 (see all 9):
    hsa-miR-4303 hsa-miR-3164 hsa-miR-3140-3p hsa-miR-642a hsa-miR-3136-5p hsa-miR-3065-3p hsa-miR-134 hsa-miR-942
    SwitchGear 3'UTR luciferase reporter plasmidANGPTL4 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 2): ANGPTL4 (NM_001039667)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ANGPTL4
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      QuantiTect SYBR Green Assays in human, mouse, rat ANGPTL4
      QuantiFast Probe-based Assays in human, mouse, rat ANGPTL4

    Additional mRNA sequence: 

    AB056477.1 AF169312.1 AF202636.1 AK222489.1 AK222524.1 AK303269.1 AY358275.1 BC023647.2 

    12 DOTS entries:

    DT.100037035  DT.443291  DT.97858809  DT.92427844  DT.121477749  DT.100801046  DT.100801049  DT.100801044 
    DT.92427846  DT.95227603  DT.121477721  DT.121477733 

    Selected AceView cDNA sequences (see all 237):

    BM677698 NM_139314 CR619101 CR615250 NM_016109 BM893904 BM893747 AW572561 
    BU739876 CA488937 BQ936529 CR615268 AI597787 AI086926 BQ927396 BQ574305 
    BG222503 BE045761 AI432962 BM720059 AY358275 CR590582 BI822252 AW293408 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for ANGPTL4    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9
    SP1:                                            -                           
    SP2:                                            -                           
    SP3:        -     -                                                         
    SP4:                                -                                       


    ECgene alternative splicing isoforms for ANGPTL4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ANGPTL4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGCTGGTGC
    ANGPTL4 Expression
    About this image


    ANGPTL4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 3 entries
             HyStem+TGFbeta3+GDF5-induced MEL2 cells
     
     Cartilage (Muscoskeletal System)    fully expand to see all 3 entries
             HyStem+TGFbeta3+GDF5-induced MEL2 cells
     
     Umbilical Cord (Extraembryonic Tissues)    fully expand to see all 2 entries
             Umbilical Arteries
             Umbilical cord blood-derived endothelial progenitor cells
     
     Adipose (Muscoskeletal System)    fully expand to see all 2 entries
             HyStem+BMP4-induced E15 cells
     
     Limb (Muscoskeletal System)
             Bone Marrow Stromal Cells Pelvic Girdle
    ANGPTL4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ANGPTL4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.9613

    UniProtKB/Swiss-Prot: ANGL4_HUMAN, Q9BY76
    Tissue specificity: Expressed at high levels in the placenta, heart, liver, muscle, pancreas and lung but
    expressed poorly in the brain and kidney

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ANGPTL4 (see all 7): 
              Nephrotoxicity in human mouse rat
              Angiogenic Growth Factors in human mouse rat
              WNT Signaling Targets in human mouse rat
              Neurotoxicity in human mouse rat
              Hypoxia Signaling Pathway in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ANGPTL4 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Angptl41 , 5 angiopoietin-like 41, 5 77.7(n)1
    76.79(a)1
      17 (17.98 cM)5
    578751  NM_020581.21  NP_065606.21 
     337737505 
    chicken
    (Gallus gallus)
    Aves ANGPTL41 angiopoietin-like 4 58.66(n)
    49.17(a)
      769087  XM_001232283.3  XP_001232284.2 
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.106692 Xenopus laevis transcribed sequence with weak similarity more 76.1(n)    48015723 
    zebrafish
    (Danio rerio)
    Actinopterygii angptl41 angiopoietin-like 4 55.06(n)
    48.88(a)
      492647  NM_001256203.1  NP_001243132.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta sca3 eye morphogenesis (sensu Drosophila)
    signal transducer
    31(a)   2 49D3   --
    worm
    (Caenorhabditis elegans)
    Secernentea T15B7.16
    Protein T15B7.1 (T15B7.1) mRNA, complete cds
    22(a)
    1 → many
    V(6842774-6846668) WBGene00020516


    ENSEMBL Gene Tree for ANGPTL4 (if available)
    TreeFam Gene Tree for ANGPTL4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ANGPTL4 gene
    TNXB2  ANGPTL32  TNR2  FGA2  TNN2  ANGPTL52  FN12  TNC2  
    13 SIMAP similar genes for ANGPTL4 using alignment to 7 protein entries:     ANGL4_HUMAN (see all proteins):
    ANGPTL2    FGG    ANGPT1    ANGPTL3    ANGPTL7    FCN1
    FCN2    FCN3    MFAP4    FGL1    LFIRE1    FIBCD1
    TNC

    ANGPTL4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ANGPTL4 (see all 380)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1168430641,2,,4
    C,Fother18365689(+) GGGACG/AAGATG 4 /K /E mis11Minor allele frequency- A:0.03NA 120
    rs1118963771,2
    C--8083358(+) CTTCT-/ACACACA 2 -- int11Minor allele frequency- AC:0.50CSA 2
    rs344097031,2
    C--8083379(+) ACACACA/-AAATA 2 -- int11Minor allele frequency- -:0.50NA 2
    rs1479460801,2
    --8363396(+) TGCACA/GTCAGC 2 -- us2k10--------
    rs1171088061,2
    C,F--8363480(+) GCCAGT/CGCTCT 2 -- us2k11Minor allele frequency- C:0.02EA 120
    rs1418491301,2
    --8363553(+) ACAGGA/GTATAG 2 -- us2k10--------
    rs1927353321,2
    --8363558(+) GTATAA/GGGGAA 2 -- us2k10--------
    rs1834964271,2
    --8363923(+) CGTCTC/GCTGAG 2 -- us2k10--------
    rs1458155881,2
    --8363936(+) CAAGCA/GATTCT 2 -- us2k10--------
    rs1883778891,2
    --8364132(+) ACCGCA/GCCTGG 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for ANGPTL4 (8428173 - 8439257 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for ANGPTL4:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv911004CNV Loss21882294
    nsv911003CNV Loss21882294
    nsv911001CNV Loss21882294
    dgv3719n71CNV Loss21882294

    Human Gene Mutation Database (HGMD): ANGPTL4
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ANGPTL4
    DNA2.0 Custom Variant and Variant Library Synthesis for ANGPTL4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605910    OMIM disorders: --

    Selected diseases for ANGPTL4 (see all 38):    
    About MalaCards
    reduced triglycerides    hepatitis    arteriovenous malformation    clear cell renal cell carcinoma
    traumatic brain injury    brain injury    lipodystrophy    hypoxia
    renal cell carcinoma    endotheliitis    coronary heart disease    bladder carcinoma
    insulin resistance    obesity    proteinuria    ischemia
    nephrotic syndrome    meningitis    kidney disease    colon adenocarcinoma


    ANGPTL4 for disorders           About GeneDecksing

    9 Novoseek inferred disease relationships for ANGPTL4 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    obesity 44.6 5 17210919 (2), 17030965 (1), 10866690 (1)
    insulin sensitivity 37 1 15837923 (1)
    insulin resistance 24.4 4 15326464 (1), 16870142 (1), 15837923 (1)
    tumors 10.9 15 12707035 (4), 20454689 (4), 18394990 (2), 17030965 (1) (see all 6)
    cancer 4.05 1 18394990 (1)
    cardiovascular diseases 0 2 19851103 (1)
    ischemia 0 2 12707035 (2)
    necrosis 0 4 17030965 (1), 15220243 (1), 15949695 (1)
    metastasis 0 4 20454689 (1), 18394990 (1), 19364815 (1), 19775228 (1)

    Genetic Association Database (GAD): ANGPTL4
    Human Genome Epidemiology (HuGE) Navigator: ANGPTL4 (14 documents)

    Export disorders for ANGPTL4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ANGPTL4 gene, integrated from 10 sources (see all 158):
    (articles sorted by number of sources associating them with ANGPTL4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Hepatic expression, synthesis and secretion of a novel fibrinogen/angiopoietin-related protein that prevents endothelial-cell apoptosis. (PubMed id 10698685)1, 2, 3, 9 Kim I....Koh G.Y. (Biochem. J. 2000)
    2. Peroxisome proliferator-activated receptor gamma target gene encoding a novel angiopoietin-related protein associated with adipose differentiation. (PubMed id 10866690)1, 2, 3, 9 Yoon J.C.... Spiegelman B.M. (Mol. Cell. Biol. 2000)
    3. Cloning of a novel gene, ANGPTL4 and the functional study in angiogenesis. (PubMed id 11953136)1, 2, 9 Zhu H.... Gu J. (Zhonghua Yi Xue Za Zhi 2002)
    4. Angiopoietin-like protein 4 inhibition of lipoprotein lipase: evidence for reversible complex formation. (PubMed id 23960078)1, 3 Lafferty M.J....Neher S.B. (J. Biol. Chem. 2013)
    5. The relationship between plasma angiopoietin-like protein 4 levels, angiopoietin-like protein 4 genotype, and coronary heart disease risk. (PubMed id 20829508)1, 4 Smart-Halajko M.C....Talmud P.J. (Arterioscler. Thromb. Vasc. Biol. 2010)
    6. Biological, clinical and population relevance of 95 loci for blood lipids. (PubMed id 20686565)1, 4 Teslovich T.M....Kathiresan S. (Nature 2010)
    7. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    8. Associations between common genetic polymorphisms in angiopoietin-like proteins 3 and 4 and lipid metabolism and adiposity in European adolescents and adults. (PubMed id 19890028)1, 4 Legry V....Meirhaeghe A. (J. Clin. Endocrinol. Metab. 2009)
    9. Candidate genetic analysis of plasma high-density lipoprotein-cholesterol and severity of coronary atherosclerosis. (PubMed id 19878569)1, 4 Chen S.N....Marian A.J. (BMC Med. Genet. 2009)
    10. Common variants at 30 loci contribute to polygenic dyslipidemia. (PubMed id 19060906)1, 4 Kathiresan S....Cupples L.A. (Nat. Genet. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 51129 HGNC: 16039 AceView: ANGPTL4 Ensembl:ENSG00000167772 euGenes: HUgn51129
    ECgene: ANGPTL4 Kegg: 51129 H-InvDB: ANGPTL4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ANGPTL4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ANGPTL4 gene:
    Search GeneIP for patents involving ANGPTL4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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