Aliases for ANGPTL4 Gene
Aliases for ANGPTL4 Gene
- Angiopoietin Like 4 2 3 5
- Hepatic Fibrinogen/Angiopoietin-Related Protein 2 3 4
- Peroxisome Proliferator-Activated Receptor (PPAR) Gamma Induced Angiopoietin-Related Protein 2 3
- Hepatic Angiopoietin-Related Protein 2 3
- PPARG Angiopoietin Related Protein 2 3
- Fasting-Induced Adipose Factor 2 3
- Angiopoietin-Related Protein 4 2 3
- HFARP 3 4
- Arp4 3 4
- PGAR 3 4
External Ids for ANGPTL4 Gene
- HGNC: 16039
- Entrez Gene: 51129
- Ensembl: ENSG00000167772
- OMIM: 605910
- UniProtKB: Q9BY76
Previous GeneCards Identifiers for ANGPTL4 Gene
- GC19P008372
- GC19P008643
- GC19P008324
- GC19P008335
- GC19P008429
- GC19P008082
Summaries for ANGPTL4 Gene
-
This gene encodes a glycosylated, secreted protein containing a C-terminal fibrinogen domain. The encoded protein is induced by peroxisome proliferation activators and functions as a serum hormone that regulates glucose homeostasis, lipid metabolism, and insulin sensitivity. This protein can also act as an apoptosis survival factor for vascular endothelial cells and can prevent metastasis by inhibiting vascular growth and tumor cell invasion. The C-terminal domain may be proteolytically-cleaved from the full-length secreted protein. Decreased expression of this gene has been associated with type 2 diabetes. Alternative splicing results in multiple transcript variants. This gene was previously referred to as ANGPTL2 but has been renamed ANGPTL4. [provided by RefSeq, Sep 2013]
GeneCards Summary for ANGPTL4 Gene
ANGPTL4 (Angiopoietin Like 4) is a Protein Coding gene. Diseases associated with ANGPTL4 include Plasma Triglyceride Level Qtl, Low and Severe Nonproliferative Diabetic Retinopathy. Among its related pathways are Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) and Lipoprotein metabolism. GO annotations related to this gene include enzyme inhibitor activity. An important paralog of this gene is ANGPTL3.
UniProtKB/Swiss-Prot for ANGPTL4 Gene
-
Protein with hypoxia-induced expression in endothelial cells. May act as a regulator of angiogenesis and modulate tumorigenesis. Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. May exert a protective function on endothelial cells through an endocrine action. It is directly involved in regulating glucose homeostasis, lipid metabolism, and insulin sensitivity. In response to hypoxia, the unprocessed form of the protein accumulates in the subendothelial extracellular matrix (ECM). The matrix-associated and immobilized unprocessed form limits the formation of actin stress fibers and focal contacts in the adhering endothelial cells and inhibits their adhesion. It also decreases motility of endothelial cells and inhibits the sprouting and tube formation (By similarity).
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANGPTL4 Gene
Genomics for ANGPTL4 Gene
Regulatory Elements for ANGPTL4 Gene
Enhancers for ANGPTL4 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around ANGPTL4 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the ANGPTL4 gene promoter:
Regulatory Element Products
Genomic Location for ANGPTL4 Gene
- Chromosome:
- 19
- Start:
- 8,363,289 bp from pter
- End:
- 8,374,375 bp from pter
- Size:
- 11,087 bases
- Orientation:
- Plus strand
Genomic View for ANGPTL4 Gene
Genes around ANGPTL4 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19p13.2 by Ensembl
- 19p13.2 by Entrez Gene
- 19p13.2 by HGNC
ANGPTL4 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ANGPTL4 Gene
Proteins for ANGPTL4 Gene
-
Protein details for ANGPTL4 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9BY76-ANGL4_HUMAN
- Recommended name:
- Angiopoietin-related protein 4
- Protein Accession:
- Q9BY76
- A8MY84
- B4E089
- D6W670
- F5H0I2
- Q53HQ6
- Q53HU1
- Q6UXN0
- Q9HBV4
- Q9NZU4
- Q9Y5B3
Protein attributes for ANGPTL4 Gene
- Size:
- 406 amino acids
- Molecular mass:
- 45214 Da
- Quaternary structure:
-
- Homooligomer. The homooligomer undergoes proteolytic processing to release its carboxyl fibrinogen-like domain, which circulates as a monomer. The homooligomer unprocessed form is able to interact with the extracellular matrix (By similarity).
- SequenceCaution:
-
- Sequence=AAQ88642.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Protein Expression for ANGPTL4 Gene
Post-translational modifications for ANGPTL4 Gene
- N-glycosylated.
- Glycosylation at posLast=177177
- Modification sites at PhosphoSitePlus
Other Protein References for ANGPTL4 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for ANGPTL4
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Santa Cruz Biotechnology (SCBT) Antibodies for ANGPTL4
Protein Products
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Assay Products
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Abcam assays for ANGPTL4
No data available for DME Specific Peptides for ANGPTL4 Gene
Domains & Families for ANGPTL4 Gene
Gene Families for ANGPTL4 Gene
Protein Domains for ANGPTL4 Gene
Suggested Antigen Peptide Sequences for ANGPTL4 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for ANGPTL4 Gene
Function for ANGPTL4 Gene
Molecular function for ANGPTL4 Gene
- UniProtKB/Swiss-Prot Function:
- Protein with hypoxia-induced expression in endothelial cells. May act as a regulator of angiogenesis and modulate tumorigenesis. Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. May exert a protective function on endothelial cells through an endocrine action. It is directly involved in regulating glucose homeostasis, lipid metabolism, and insulin sensitivity. In response to hypoxia, the unprocessed form of the protein accumulates in the subendothelial extracellular matrix (ECM). The matrix-associated and immobilized unprocessed form limits the formation of actin stress fibers and focal contacts in the adhering endothelial cells and inhibits their adhesion. It also decreases motility of endothelial cells and inhibits the sprouting and tube formation (By similarity).
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004857 | enzyme inhibitor activity | ISS | -- |
| GO:0005515 | protein binding | IPI | 21397862 |
| GO:0042802 | identical protein binding | IPI | 19028676 |
Phenotypes for ANGPTL4 Gene
- MGI mutant phenotypes for ANGPTL4:
- inferred from 7 alleles
- GenomeRNAi human phenotypes for ANGPTL4:
Animal Models for ANGPTL4 Gene
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miRNA for ANGPTL4 Gene
- miRTarBase miRNAs that target ANGPTL4
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
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- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
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Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ANGPTL4 Gene
Localization for ANGPTL4 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ANGPTL4 Gene
- Secreted. Secreted, extracellular space, extracellular matrix. Note=The unprocessed form interacts with the extracellular matrix. This may constitute a dynamic reservoir, a regulatory mechanism of the bioavailability of ANGPTL4 (By similarity). {ECO:0000250}.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| peroxisome | 2 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| nucleus | 1 |
| endoplasmic reticulum | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | TAS | -- |
| GO:0005578 | proteinaceous extracellular matrix | IEA | -- |
| GO:0005615 | extracellular space | IDA | 10698685 |
| GO:0072562 | blood microparticle | IDA | 22516433 |
Pathways & Interactions for ANGPTL4 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) | ||
| 2 | Lipoprotein metabolism | ||
| 3 | Metabolism |
.37
|
|
| 4 | PPAR signaling pathway | ||
| 5 | Developmental Biology | ||
Pathways by source for ANGPTL4 Gene
1 KEGG pathway for ANGPTL4 Gene
Interacting Proteins for ANGPTL4 Gene
Selected Interacting proteins:
ENSP00000301455
Q9BY76-ANGL4_HUMAN
for ANGPTL4 Gene via
STRING
UniProtKB
IID
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001525 | angiogenesis | IEA | -- |
| GO:0001666 | response to hypoxia | NAS | 12707035 |
| GO:0007275 | multicellular organism development | IEA | -- |
| GO:0019216 | regulation of lipid metabolic process | TAS | -- |
| GO:0030154 | cell differentiation | IEA | -- |
No data available for SIGNOR curated interactions for ANGPTL4 Gene
Transcripts for ANGPTL4 Gene
mRNA/cDNA for ANGPTL4 Gene
- (5) REFSEQ mRNAs :
- (8) Additional mRNA sequences :
- (237) Selected AceView cDNA sequences:
- (11) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
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miRNA Products
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Inhibitory RNA Products
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Clone Products
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- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ANGPTL4
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||||
| SP4: | - |
Expression for ANGPTL4 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Bone (Muscoskeletal System)
- Cartilage (Muscoskeletal System)
- Umbilical Cord (Extraembryonic Tissues)
- Adipose (Muscoskeletal System)
-
Limb (Muscoskeletal System)
- Bone Marrow Stromal Cells Pelvic Girdle
-
Mesenchymal Stem Cells
- Bone Marrow Stromal Cells Pelvic Girdle
- Brain (Nervous System)
- Endothelium (Cardiovascular System)
-
Liver (Hepatobiliary System)
mRNA differential expression in normal tissues according to GTEx for ANGPTL4 Gene
This gene is overexpressed in Adipose - Subcutaneous (x5.1), Liver (x4.8), and Adipose - Visceral (Omentum) (x4.4).
This gene is overexpressed in Islet of Langerhans (20.9), Milk (18.4), and Bone marrow mesenchymal stem cell (18.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ANGPTL4 Gene
NURSA nuclear receptor signaling pathways regulating expression of ANGPTL4 Gene:
ANGPTL4SOURCE GeneReport for Unigene cluster for ANGPTL4 Gene:
Hs.9613mRNA Expression by UniProt/SwissProt for ANGPTL4 Gene:
Q9BY76-ANGL4_HUMAN
Tissue specificity:
Expressed at high levels in the placenta, heart, liver, muscle, pancreas and lung but expressed poorly in the brain and kidney.
Evidence on tissue expression from TISSUES for ANGPTL4 Gene
- Pancreas(4.4)
- Skin(4.4)
- Nervous system(3.1)
- Liver(2.8)
- Heart(2.1)
- Intestine(2.1)
Primer Products
-
OriGene qPCR primer pairs for ANGPTL4
-
OriGene qPCR primer pairs and template standards for ANGPTL4
No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ANGPTL4 Gene
Orthologs for ANGPTL4 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ANGPTL4 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | ANGPTL4 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | ANGPTL4 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Angptl4 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Angptl4 34 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | ANGPTL4 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | ANGPTL4 34 35 |
|
||
| tropical clawed frog (Silurana tropicalis) |
Amphibia | angptl4 34 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.10669 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | angptl4 34 35 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | sca 36 |
|
|
|
| CG7668 35 |
|
OneToMany | |||
| worm (Caenorhabditis elegans) |
Secernentea | T15B7.1 35 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
OneToMany |
- Species where no ortholog for ANGPTL4 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for ANGPTL4 Gene
Paralogs for ANGPTL4 Gene
(13) SIMAP similar genes for ANGPTL4 Gene using alignment to 7 proteins:
Variants for ANGPTL4 Gene
Polymorphic Variants from UniProtKB/Swiss-Prot for ANGPTL4 Gene
- ANGL4_HUMAN-Q9BY76
- Genetic variations in ANGPTL4 are associated with low plasma triglyceride levels and define the plasma triglyceride level quantitative trait locus (TGQTL) [MIM:615881].
| SNP ID | Clin | Chr 19 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs116843064 | other | 8,364,439(+) | GGGAC(A/G)AGATG | nc-transcript-variant, reference, missense | |
| rs587777517 | other | 8,369,320(+) | ACTGC(A/T)AGATG | intron-variant, reference, stop-gained | |
| rs1000182337 | -- | 8,372,823(+) | ATGGT(A/G)GCTCA | intron-variant | |
| rs1000235949 | -- | 8,372,621(+) | AATCC(G/T)GTCTC | intron-variant | |
| rs1000584534 | -- | 8,362,163(+) | GTGTG(C/T)AGTTT | upstream-variant-2KB |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3643614 | CNV | gain | 21293372 |
| esv3643616 | CNV | gain | 21293372 |
Residual Variation Intolerance Score:
65.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
6.86;
79.38% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for ANGPTL4 Gene
Disorders for ANGPTL4 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| plasma triglyceride level qtl, low |
|
|
| severe nonproliferative diabetic retinopathy |
|
|
| obesity |
|
Search ANGPTL4 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for ANGPTL4
No data available for UniProtKB/Swiss-Prot and Genatlas for ANGPTL4 Gene
Publications for ANGPTL4 Gene
- Hepatic expression, synthesis and secretion of a novel fibrinogen/angiopoietin-related protein that prevents endothelial-cell apoptosis. (PMID: 10698685) Kim I. … Koh G.Y. (Biochem. J. 2000) 2 3 4 22 64
- Peroxisome proliferator-activated receptor gamma target gene encoding a novel angiopoietin-related protein associated with adipose differentiation. (PMID: 10866690) Yoon J.C. … Spiegelman B.M. (Mol. Cell. Biol. 2000) 2 3 4 22 64
- Cloning of a novel gene, ANGPTL4 and the functional study in angiogenesis. (PMID: 11953136) Zhu H. … Gu J. (Zhonghua Yi Xue Za Zhi 2002) 3 4 22 64
- Angiopoietin-like protein 4 inhibition of lipoprotein lipase: evidence for reversible complex formation. (PMID: 23960078) Lafferty M.J. … Neher S.B. (J. Biol. Chem. 2013) 2 3 64
- Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
Products for ANGPTL4 Gene
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- Search ViGene Biosciences for ANGPTL4
- Santa Cruz Biotechnology (SCBT) Antibodies for ANGPTL4
- Search Santa Cruz Biotechnology (SCBT) for ANGPTL4 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for ANGPTL4
- Horizon Cell Lines for ANGPTL4
- Cyagen custom Knockout/knockin (KOKI) mouse models for ANGPTL4
- VectorBuilder custom plasmid, inducible vectors for ANGPTL4
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ANGPTL4
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for ANGPTL4 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer