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Aliases for ANGPTL3 Gene

Aliases for ANGPTL3 Gene

  • Angiopoietin-Like 3 2 3
  • ANGPT5 3 4 6
  • Angiopoietin 5 2 3
  • FHBL2 3 6
  • ANG-5 3 4
  • Angiopoietin-Related Protein 3 3
  • Angiopoietin-Like Protein 3 4
  • Angiopoietin-5 4
  • ANL3 3

External Ids for ANGPTL3 Gene

Previous HGNC Symbols for ANGPTL3 Gene

  • ANGPT5

Previous GeneCards Identifiers for ANGPTL3 Gene

  • GC01P062998
  • GC01P061986
  • GC01P062420
  • GC01P062433
  • GC01P062775
  • GC01P061175

Summaries for ANGPTL3 Gene

Entrez Gene Summary for ANGPTL3 Gene

  • This gene encodes a member of a family of secreted proteins that function in angiogenesis. The encoded protein, which is expressed predominantly in the liver, is further processed into an N-terminal coiled-coil domain-containing chain and a C-terminal fibrinogen chain. The N-terminal chain is important for lipid metablism, while the C-terminal chain may be involved in angiogenesis. Mutations in this gene cause familial hypobetalipoproteinemia type 2. [provided by RefSeq, Feb 2013]

GeneCards Summary for ANGPTL3 Gene

ANGPTL3 (Angiopoietin-Like 3) is a Protein Coding gene. Diseases associated with ANGPTL3 include hypobetalipoproteinemia, familial, 2 and abetalipoproteinemia. Among its related pathways are Integrins in angiogenesis. GO annotations related to this gene include growth factor activity and enzyme inhibitor activity. An important paralog of this gene is TNC.

Gene Wiki entry for ANGPTL3 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANGPTL3 Gene

Genomics for ANGPTL3 Gene

Regulatory Elements for ANGPTL3 Gene

Genomic Location for ANGPTL3 Gene

62,597,487 bp from pter
62,606,305 bp from pter
8,819 bases
Plus strand

Genomic View for ANGPTL3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ANGPTL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANGPTL3 Gene

Proteins for ANGPTL3 Gene

  • Protein details for ANGPTL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Angiopoietin-related protein 3
    Protein Accession:
    Secondary Accessions:
    • A0JLS0
    • B1ALJ0
    • B2RCW1

    Protein attributes for ANGPTL3 Gene

    460 amino acids
    Molecular mass:
    53637 Da
    Quaternary structure:
    • Interacts with C19orf80/ANGPTL8.
    • Sequence=AAH07059.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

neXtProt entry for ANGPTL3 Gene

Proteomics data for ANGPTL3 Gene at MOPED

Post-translational modifications for ANGPTL3 Gene

  • Glycosylation at Asn115, Asn296, and Asn357
  • Modification sites at PhosphoSitePlus

Other Protein References for ANGPTL3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for ANGPTL3 (Angiopoietin-like Protein 3/ANGPTL3)

No data available for DME Specific Peptides for ANGPTL3 Gene

Domains for ANGPTL3 Gene

Gene Families for ANGPTL3 Gene

  • FIBC :Fibrinogen C domain containing

Suggested Antigen Peptide Sequences for ANGPTL3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q9Y5C1
  • Contains 1 fibrinogen C-terminal domain.
genes like me logo Genes that share domains with ANGPTL3: view

Function for ANGPTL3 Gene

Molecular function for ANGPTL3 Gene

GENATLAS Biochemistry: angiopoietin-like 3,predominantly expressed in the liver

Gene Ontology (GO) - Molecular Function for ANGPTL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004857 enzyme inhibitor activity ISS --
GO:0004859 phospholipase inhibitor activity IDA 17110602
GO:0005178 integrin binding IPI 11877390
GO:0008083 growth factor activity IDA 11877390
genes like me logo Genes that share ontologies with ANGPTL3: view
genes like me logo Genes that share phenotypes with ANGPTL3: view

Animal Models for ANGPTL3 Gene

MGI Knock Outs for ANGPTL3:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ANGPTL3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for ANGPTL3 Gene

Localization for ANGPTL3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ANGPTL3 Gene


Subcellular locations from

Jensen Localization Image for ANGPTL3 Gene COMPARTMENTS Subcellular localization image for ANGPTL3 gene
Compartment Confidence
extracellular 4
endoplasmic reticulum 2
cytosol 1

Gene Ontology (GO) - Cellular Components for ANGPTL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 17110602
GO:0009986 cell surface IDA 12565906
genes like me logo Genes that share ontologies with ANGPTL3: view

Pathways for ANGPTL3 Gene

SuperPathways for ANGPTL3 Gene

Superpath Contained pathways
1 Integrins in angiogenesis
genes like me logo Genes that share pathways with ANGPTL3: view

Pathways by source for ANGPTL3 Gene

1 BioSystems pathway for ANGPTL3 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Angiogenic Growth Factors in human,mouse,rat
    • Lipoprotein Signaling & Cholesterol Metabolism in human,mouse,rat

Interacting Proteins for ANGPTL3 Gene

Gene Ontology (GO) - Biological Process for ANGPTL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006071 glycerol metabolic process IDA 12565906
GO:0006631 fatty acid metabolic process IDA 12565906
GO:0006644 phospholipid metabolic process IDA 17110602
GO:0007160 cell-matrix adhesion IPI 11877390
GO:0007165 signal transduction IDA 11877390
genes like me logo Genes that share ontologies with ANGPTL3: view

Compounds for ANGPTL3 Gene

(3) Novoseek inferred chemical compound relationships for ANGPTL3 Gene

Compound -log(P) Hits PubMed IDs
cholesterol 35.1 5
lipid 32.3 8
fibrinogen 17.1 2
genes like me logo Genes that share compounds with ANGPTL3: view

Transcripts for ANGPTL3 Gene

mRNA/cDNA for ANGPTL3 Gene

Unigene Clusters for ANGPTL3 Gene

Angiopoietin-like 3:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ANGPTL3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ANGPTL3 Gene

No ASD Table

Relevant External Links for ANGPTL3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ANGPTL3 Gene

mRNA expression in normal human tissues for ANGPTL3 Gene

mRNA differential expression in normal tissues according to GTEx for ANGPTL3 Gene

This gene is overexpressed in Liver (50.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ANGPTL3 Gene

SOURCE GeneReport for Unigene cluster for ANGPTL3 Gene Hs.209153

mRNA Expression by UniProt/SwissProt for ANGPTL3 Gene

Tissue specificity: Expressed principally in liver. Weakly expressed in kidney.
genes like me logo Genes that share expressions with ANGPTL3: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for ANGPTL3 Gene

Orthologs for ANGPTL3 Gene

This gene was present in the common ancestor of animals.

Orthologs for ANGPTL3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ANGPTL3 35
  • 99.78 (n)
  • 99.57 (a)
  • 100 (a)
(Bos Taurus)
Mammalia ANGPTL3 35
  • 88.16 (n)
  • 83.22 (a)
  • 83 (a)
(Canis familiaris)
Mammalia ANGPTL3 35
  • 90.2 (n)
  • 88.02 (a)
  • 88 (a)
(Mus musculus)
Mammalia Angptl3 35
  • 80.4 (n)
  • 76.65 (a)
Angptl3 16
Angptl3 36
  • 76 (a)
(Monodelphis domestica)
Mammalia ANGPTL3 36
  • 69 (a)
(Ornithorhynchus anatinus)
Mammalia ANGPTL3 36
  • 62 (a)
(Rattus norvegicus)
Mammalia Angptl3 35
  • 83.12 (n)
  • 80.13 (a)
(Gallus gallus)
Aves ANGPTL3 35
  • 64.34 (n)
  • 56.21 (a)
  • 53 (a)
(Anolis carolinensis)
Reptilia ANGPTL3 36
  • 52 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC496885 35
  • 62.66 (n)
  • 55.23 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9678 35
(Danio rerio)
Actinopterygii angptl3 35
  • 55.8 (n)
  • 47.58 (a)
angptl3 36
  • 44 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7668 36
  • 23 (a)
(Caenorhabditis elegans)
Secernentea T15B7.1 36
  • 21 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 39 (a)
Species with no ortholog for ANGPTL3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ANGPTL3 Gene

Gene Tree for ANGPTL3 (if available)
Gene Tree for ANGPTL3 (if available)

Paralogs for ANGPTL3 Gene

Paralogs for ANGPTL3 Gene

Selected SIMAP similar genes for ANGPTL3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ANGPTL3: view

Variants for ANGPTL3 Gene

Sequence variations from dbSNP and Humsavar for ANGPTL3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
VAR_049071 -
VAR_067283 -

Structural Variations from Database of Genomic Variants (DGV) for ANGPTL3 Gene

Variant ID Type Subtype PubMed ID
nsv870559 CNV Loss 21882294

Relevant External Links for ANGPTL3 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANGPTL3 Gene

Disorders for ANGPTL3 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (3) Diseases for ANGPTL3 Gene including...

Search for ANGPTL3 Gene in MalaCards »

(1) OMIM Diseases for ANGPTL3 Gene (604774)


  • Hypobetalipoproteinemia, familial, 2 (FHBL2) [MIM:605019]: A disorder of lipid metabolism characterized by less than 5th percentile age- and sex-specific levels of low density lipoproteins, and dietary fat malabsorption. Affected individuals present with combined hypolipidemia, consisting of extremely low plasma levels of LDL cholesterol, HDL cholesterol, and triglycerides. {ECO:0000269 PubMed:20942659}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(2) University of Copenhagen DISEASES for ANGPTL3 Gene

(1) Novoseek inferred disease relationships for ANGPTL3 Gene

Disease -log(P) Hits PubMed IDs
atherosclerosis 37.1 4

Relevant External Links for ANGPTL3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with ANGPTL3: view

Publications for ANGPTL3 Gene

  1. Identification of a mammalian angiopoietin-related protein expressed specifically in liver. (PMID: 10644446) Conklin D. … Lewis K.B. (Genomics 1999) 2 3 4 23
  2. Angiopoietin-like protein 3, a hepatic secretory factor, activates lipolysis in adipocytes. (PMID: 12565906) Shimamura M. … Shimomura I. (Biochem. Biophys. Res. Commun. 2003) 3 23
  3. Protein region important for regulation of lipid metabolism in angiopoietin-like 3 (ANGPTL3): ANGPTL3 is cleaved and activated in vivo. (PMID: 12909640) Ono M. … Furukawa H. (J. Biol. Chem. 2003) 3 23
  4. Hepatic proprotein convertases modulate HDL metabolism. (PMID: 17681148) Jin W. … Rader D.J. (Cell Metab. 2007) 3 23
  5. Angiopoietin-like protein 3: development, analytical characterization, and clinical testing of a new ELISA. (PMID: 18063851) Stejskal D. … Stejskal P. (Gen. Physiol. Biophys. 2007) 3 23

Products for ANGPTL3 Gene

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Angiogenic Growth Factors in human,mouse,rat
    • Lipoprotein Signaling & Cholesterol Metabolism in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate ANGPTL3
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for ANGPTL3
    • Block miRNA regulation of ANGPTL3 using miScript Target Protectors

    Sources for ANGPTL3 Gene

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