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Aliases for ANGPTL2 Gene

Aliases for ANGPTL2 Gene

  • Angiopoietin Like 2 2 3 5
  • Angiopoietin-Like Protein 2 3 4
  • Angiopoietin-Like 2 2 3
  • ARP2 3 4
  • HARP 3

External Ids for ANGPTL2 Gene

Previous GeneCards Identifiers for ANGPTL2 Gene

  • GC09M120965
  • GC09M121496
  • GC09M123303
  • GC09M125226
  • GC09M125225
  • GC09M126929
  • GC09M128889
  • GC09M129849
  • GC09M099465

Summaries for ANGPTL2 Gene

Entrez Gene Summary for ANGPTL2 Gene

  • Angiopoietins are members of the vascular endothelial growth factor family and the only known growth factors largely specific for vascular endothelium. Angiopoietin-1, angiopoietin-2, and angiopoietin-4 participate in the formation of blood vessels. ANGPTL2 protein is a secreted glycoprotein with homology to the angiopoietins and may exert a function on endothelial cells through autocrine or paracrine action. [provided by RefSeq, Jul 2008]

GeneCards Summary for ANGPTL2 Gene

ANGPTL2 (Angiopoietin Like 2) is a Protein Coding gene. Among its related pathways are IL-7 Signaling Pathways. GO annotations related to this gene include receptor binding. An important paralog of this gene is FGB.

UniProtKB/Swiss-Prot for ANGPTL2 Gene

  • Induces sprouting in endothelial cells through an autocrine and paracrine action.

Gene Wiki entry for ANGPTL2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANGPTL2 Gene

Genomics for ANGPTL2 Gene

Regulatory Elements for ANGPTL2 Gene

Enhancers for ANGPTL2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ANGPTL2 on UCSC Golden Path with GeneCards custom track

Promoters for ANGPTL2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ANGPTL2 on UCSC Golden Path with GeneCards custom track

Genomic Location for ANGPTL2 Gene

127,087,332 bp from pter
127,122,883 bp from pter
35,552 bases
Minus strand

Genomic View for ANGPTL2 Gene

Genes around ANGPTL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANGPTL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANGPTL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANGPTL2 Gene

Proteins for ANGPTL2 Gene

  • Protein details for ANGPTL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Angiopoietin-related protein 2
    Protein Accession:
    Secondary Accessions:
    • Q5JT58
    • Q8NCH7

    Protein attributes for ANGPTL2 Gene

    493 amino acids
    Molecular mass:
    57104 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ANGPTL2 Gene


neXtProt entry for ANGPTL2 Gene

Proteomics data for ANGPTL2 Gene at MOPED

Post-translational modifications for ANGPTL2 Gene

Other Protein References for ANGPTL2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for ANGPTL2 (Angiopoietin-like Protein 2/ANGPTL2)

No data available for DME Specific Peptides for ANGPTL2 Gene

Domains & Families for ANGPTL2 Gene

Gene Families for ANGPTL2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 fibrinogen C-terminal domain.
  • Contains 1 fibrinogen C-terminal domain.
genes like me logo Genes that share domains with ANGPTL2: view

Function for ANGPTL2 Gene

Molecular function for ANGPTL2 Gene

UniProtKB/Swiss-Prot Function:
Induces sprouting in endothelial cells through an autocrine and paracrine action.
genes like me logo Genes that share phenotypes with ANGPTL2: view

Animal Models for ANGPTL2 Gene

MGI Knock Outs for ANGPTL2:

Animal Model Products

  • Taconic Biosciences Mouse Models for ANGPTL2

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ANGPTL2 Gene

Localization for ANGPTL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ANGPTL2 Gene


Subcellular locations from

Jensen Localization Image for ANGPTL2 Gene COMPARTMENTS Subcellular localization image for ANGPTL2 gene
Compartment Confidence
extracellular 5
peroxisome 2
endoplasmic reticulum 1
lysosome 1
plasma membrane 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for ANGPTL2 Gene

Pathways & Interactions for ANGPTL2 Gene

SuperPathways for ANGPTL2 Gene

genes like me logo Genes that share pathways with ANGPTL2: view

Pathways by source for ANGPTL2 Gene

1 R&D Systems pathway for ANGPTL2 Gene

Interacting Proteins for ANGPTL2 Gene

Gene Ontology (GO) - Biological Process for ANGPTL2 Gene


No data available for SIGNOR curated interactions for ANGPTL2 Gene

Drugs & Compounds for ANGPTL2 Gene

No Compound Related Data Available

Transcripts for ANGPTL2 Gene

Unigene Clusters for ANGPTL2 Gene

Angiopoietin-like 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ANGPTL2 Gene

No ASD Table

Relevant External Links for ANGPTL2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ANGPTL2 Gene

mRNA expression in normal human tissues for ANGPTL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ANGPTL2 Gene

This gene is overexpressed in Urine (31.2), Gallbladder (13.2), Urinary Bladder (6.8), and Ovary (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ANGPTL2 Gene

SOURCE GeneReport for Unigene cluster for ANGPTL2 Gene Hs.653262

mRNA Expression by UniProt/SwissProt for ANGPTL2 Gene

Tissue specificity: Widely expressed in heart, small intestine, spleen and stomach. Also found in lower levels in colon, ovary, adrenal gland, skeletal muscle and in prostate.
genes like me logo Genes that share expression patterns with ANGPTL2: view

Protein tissue co-expression partners for ANGPTL2 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues for ANGPTL2 Gene

Orthologs for ANGPTL2 Gene

This gene was present in the common ancestor of animals.

Orthologs for ANGPTL2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ANGPTL2 35
  • 91.95 (n)
  • 97.97 (a)
  • 98 (a)
(Canis familiaris)
Mammalia ANGPTL2 35
  • 92.09 (n)
  • 96.75 (a)
  • 97 (a)
(Mus musculus)
Mammalia Angptl2 35
  • 89.32 (n)
  • 95.33 (a)
Angptl2 16
Angptl2 36
  • 95 (a)
(Pan troglodytes)
Mammalia ANGPTL2 35
  • 99.46 (n)
  • 99.39 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Angptl2 35
  • 89.11 (n)
  • 94.73 (a)
(Monodelphis domestica)
Mammalia ANGPTL2 36
  • 90 (a)
(Ornithorhynchus anatinus)
Mammalia ANGPTL2 36
  • 88 (a)
(Gallus gallus)
Aves ANGPTL2 35
  • 73.24 (n)
  • 88.59 (a)
  • 88 (a)
(Anolis carolinensis)
Reptilia ANGPTL2 36
  • 83 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia angptl2 35
  • 79.39 (n)
  • 83.67 (a)
(Danio rerio)
Actinopterygii angptl2b 35
  • 74.57 (n)
  • 81.08 (a)
ANGPTL2 (3 of 3) 36
  • 61 (a)
angptl2a 36
  • 71 (a)
angptl2b 36
  • 75 (a)
fruit fly
(Drosophila melanogaster)
Insecta BG:DS00929.7 37
  • 45 (a)
CG1791 37
  • 43 (a)
CG1889 37
  • 38 (a)
CG30280 37
  • 46 (a)
CG30281 37
  • 46 (a)
CG8642 37
  • 44 (a)
CG9500 37
  • 37 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 43 (a)
Species with no ortholog for ANGPTL2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ANGPTL2 Gene

Gene Tree for ANGPTL2 (if available)
Gene Tree for ANGPTL2 (if available)

Paralogs for ANGPTL2 Gene

Paralogs for ANGPTL2 Gene

genes like me logo Genes that share paralogs with ANGPTL2: view

Variants for ANGPTL2 Gene

Variation tolerance for ANGPTL2 Gene

Residual Variation Intolerance Score: 8.08% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.53; 77.75% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for ANGPTL2 Gene

Disorders for ANGPTL2 Gene

Relevant External Links for ANGPTL2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ANGPTL2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANGPTL2 Gene

Publications for ANGPTL2 Gene

  1. Molecular cloning, expression, and characterization of angiopoietin- related protein. angiopoietin-related protein induces endothelial cell sprouting. (PMID: 10473614) Kim I. … Koh G.Y. (J. Biol. Chem. 1999) 2 3 4 23 67
  2. Synoviocyte-derived angiopoietin-like protein 2 contributes to synovial chronic inflammation in rheumatoid arthritis. (PMID: 20304962) Okada T. … Oike Y. (Am. J. Pathol. 2010) 3 23
  3. Enhanced expression of ANGPTL2 in the microvascular lesions of diabetic glomerulopathy. (PMID: 17347581) Sun H. … Li L.S. (Nephron Exp. Nephrol. 2007) 3 23
  4. Angiopoietin-like protein 2 induces androgen-independent and malignant behavior in human prostate cancer cells. (PMID: 25370833) Sato R. … Mimata H. (Oncol. Rep. 2015) 3
  5. Angiopoietin-like protein 2 is a potential biomarker for gastric cancer. (PMID: 25484242) Yoshinaga T. … Yoshida M. (Mol Med Rep 2015) 3

Products for ANGPTL2 Gene

Sources for ANGPTL2 Gene