ANGPTL2 Gene
protein-coding GIFtS : 52
GCID: GC09 M129849
angiopoietin-like 2
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Aliasesfor ANGPTL2 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Angiopoietin-Like 2 1 2 ARP21 2 3 HARP1 2 Angiopoietin-Like Protein 22 3 Angiopoietin-Related Protein 22
Export aliases for ANGPTL2 gene to outside databases Previous GC identifers: GC09M120965 GC09M121496 GC09M123303 GC09M125226 GC09M125225 GC09M126929 GC09M128889 GC09M099465
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Summariesfor ANGPTL2 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for ANGPTL2 : Angiopoietins are members of the vascular endothelial growth factor family and the only known growth factors largely specific for vascular endothelium. Angiopoietin-1, angiopoietin-2, and angiopoietin-4 participate in the formation of blood vessels. ANGPTL2 protein is a secreted glycoprotein with homology to the angiopoietins and may exert a function on endothelial cells through autocrine or paracrine action. (provided by RefSeq, Jul 2008) UniProtKB/Swiss-Prot: ANGL2_HUMAN, Q9UKU9 Function : Induces sprouting in endothelial cells through an autocrine and paracrine actionGene Wiki entry for ANGPTL2
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Genomic Viewsfor ANGPTL2 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000009.11 NC_018920.1 NT_008470.19 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the ANGPTL2 gene promoter: AML1a Bach2 Lmo2 PPAR-alpha HEN1 POU2F1 POU2F1a ARP-1 Other transcription factors Search SABiosciences Chromatin IP Primers for ANGPTL2 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ANGPTL2
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 9q34 Ensembl cytogenetic band: 9q33.3 HGNC cytogenetic band: 9q34 ANGPTL2 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 9 GeneLoc Exon Structure
GeneLoc location for GC09M129849: view genomic region
(about GC identifiers )
Start:
129,849,611 bp from pter
End:
129,885,162 bp from pter
Size:
35,552 bases
Orientation:
minus strand
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Proteinsfor ANGPTL2 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: ANGL2_HUMAN, Q9UKU9 (See
protein sequence )Recommended Name: Angiopoietin-related protein 2 precursor Size : 493 amino acids; 57104 Da
Subcellular location : Secreted
Secondary accessions : Q5JT58Explore the universe of human proteins at neXtProt for ANGPTL2: NX_Q9UKU9 Post-translational modifications:
N-glycosylated1
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q9UKU9 ANGPTL2 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_036230.1 ENSEMBL proteins: ENSP00000362524 ENSP00000362516 Human Recombinant Protein Products: Gene Ontology (GO): 1 cellular component term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005615 extracellular space
IEA --
ANGPTL2 for ontologies About GeneDecksing ANGPTL2 Antibody Products: Assay Products for ANGPTL2:
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Protein
Domains / Familiesfor ANGPTL2 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
ANGPTL2 for domains About GeneDecksing 4 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q9UKU9 ProtoNet protein and cluster: Q9UKU9
1 Blocks protein family : IPB002181 Fibrinogen UniProtKB/Swiss-Prot: ANGL2_HUMAN, Q9UKU9 Similarity : Contains 1 fibrinogen C-terminal domain
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Functionfor ANGPTL2 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: ANGL2_HUMAN, Q9UKU9 Function : Induces sprouting in endothelial cells through an autocrine and paracrine action
Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for ANGPTL2 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for ANGPTL2 (see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: ANGPTL2 (NM_012098 ) Sino Biological Human cDNA Clone for ANGPTL2 DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ANGPTL2 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat ANGPTL2
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANGPTL2
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005102 receptor binding
IEA --
ANGPTL2 for ontologies About GeneDecksing 1 GenomeRNAi human phenotype for ANGPTL2 :Animal Models: Mouse knock-out Angptl2 tm1Yo for ANGPTL2 6 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Angptl2) :
ANGPTL2 for phenotypes About GeneDecksing
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Pathways & Interactionsfor ANGPTL2 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Unified GeneCards pathways   About this table See pathways by source Super-pathway contained gene-specific pathways 1 IL-9 Signaling Pathways
Pathway sources See GeneCards unified pathways Show all pathways 1 R&D Systems Pathway for ANGPTL2 Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ANGPTL2 Gene Ontology (GO): 2 biological process terms (GO ID links to tree view) : About this table
ANGPTL2 for ontologies About GeneDecksing
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Drugs & Compoundsfor ANGPTL2 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for ANGPTL2 Search CenterWatch for drugs/clinical trials and news about ANGPTL2 / ANGL2
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Transcriptsfor ANGPTL2 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for ANGPTL2 gene: NM_012098.2 Unigene Cluster for ANGPTL2:
Angiopoietin-like 2 Hs.653262 [show with all ESTs ] Unigene Representative Sequence: NM_012098 4 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000373425 (uc004bqr.1 uc010mxg.1 ) ENST00000373417 ENST00000470194 ENST00000491991 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for ANGPTL2 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for ANGPTL2 (see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: ANGPTL2 (NM_012098 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ANGPTL2 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat ANGPTL2
Additional cDNA sequence: AF007150.1 AF125175.1 AK074726.1 AK075026.1 AK307175.1 AK312876.1 AY358274.1 BC012368.1
9 DOTS entries : DT.446891 DT.101982676
DT.75143048 DT.102830315 DT.92068898 DT.100778657 DT.121163490 DT.91765571 DT.100778656 24/225 AceView cDNA sequences (see all 225 ):
AF007150 BQ952353 AL598484 BQ574556 BF038694 AA350450 AL598843 BX482997 BP345694 AI625691 CB215142 BE857139 BQ446126 CD516561 AI189337 BE745986 AY358274 AA502111 BC012368 AW438656 BF038385 AI143733 BQ717905 AW298263 GeneLoc Exon Structure
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Expression for ANGPTL2 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section ANGPTL2 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: --
About this image ANGPTL2 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table See ANGPTL2 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for ANGPTL2 SOURCE GeneReport for Unigene cluster: Hs.653262 UniProtKB/Swiss-Prot: ANGL2_HUMAN, Q9UKU9 Tissue specificity : Widely expressed in heart, small intestine, spleen and stomach. Also found in lower levels incolon, ovary, adrenal gland, skeletal muscle and in prostate SABiosciences Custom PCR Arrays for ANGPTL2 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for ANGPTL2Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat ANGPTL2 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat ANGPTL2 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat ANGPTL2 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANGPTL2
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Orthologsfor ANGPTL2 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of chordates.
Orthologs for ANGPTL2 gene from 3/12 species (see all 12 ) About this table
ENSEMBL Gene Tree for ANGPTL2 (if available)TreeFam Gene Tree for ANGPTL2 (if available)
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Paralogsfor ANGPTL2 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for ANGPTL2 gene FGL2 2 ANGPT4 2 FGA 2 FGG 2 ANGPTL6 2 ANGPTL4 2 ANGPT1 2 ANGPTL3 2 ANGPTL1 2 ANGPTL7 2 FGB 2 ANGPT2 2 FGL1 2 18/23 SIMAP similar genes for ANGPTL2 using alignment to 2 protein entries: ANGL2_HUMAN (see all proteins )
(see all similar genes ):ANGPTL1 ANGPTL6 FCN3 MFAP4 TNR TNXB ANGPTL7 FCN1 FGL1 LFIRE1 ANGPTL3 ANGPTL4 FCN2 FIBCD1 ANGPT1 ANGPT4 TNC TNC variant protein
ANGPTL2 for paralogs About GeneDecksing
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Genomic Variantsfor ANGPTL2 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing ANGPTL2
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Disorders
/ Diseasesfor ANGPTL2 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
ANGPTL2 for disorders About GeneDecksing
OMIM gene information: 605001
OMIM disorders : --12 diseases for ANGPTL2 : About MalaCards alveolar soft part sarcoma basal cell carcinoma insulin resistance renal cell carcinoma glomerulopathy rheumatoid arthritis arthritis ovarian cancer obesity sarcoma carcinoma prostatitis Export disorders for ANGPTL2 gene to outside databases
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Publicationsfor ANGPTL2 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for ANGPTL2 gene, integrated from 9 sources (see all 21 ): (articles sorted by number of sources associating them with ANGPTL2) Utopia : connect your pdf to the dynamic world of online information
Molecular cloning, expression, and characterization of angiopoietin- related protein. angiopoietin-related protein induces endothelial cell sprouting. (PubMed id 10473614) 1 , 2 , 3, 9 Kim I....Koh G.Y. (1999) DNA sequence and analysis of human chromosome 9. (PubMed id 15164053) 1 , 2 Humphray S.J.... Dunham I. (2004) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309) 1 , 2 Clark H.F.... Gray A.M. (2003) Enhanced expression of ANGPTL2 in the microvascular lesions of diabetic glomerulopathy. (PubMed id 17347581) 1 , 9 Sun H....Li L.S. (2007) Synoviocyte-derived angiopoietin-like protein 2 contr ibutes to synovial chronic inflammation in rheumatoid arthritis. (PubMed id 20304962) 1 , 9 Okada T....Oike Y. (2010) Tumor cell-derived angiopoietin-like protein ANGPTL2 i s a critical driver of metastasis. (PubMed id 22345152) 1 Endo M....Oike Y. (2012) Macrophage-derived angiopoietin-like protein 2 acceler ates development of abdominal aortic aneurysm. (PubMed id 22556334) 1 Tazume H....Oike Y. (2012) Angiopoietin-like-2 and -3 act through their coiled-co il domains to enhance survival and replating capacity of human cord blood hemato poietic progenitors. (PubMed id 21983347) 1 Broxmeyer H.E....Youn B.S. (2012) The role of angiopoietin-like protein 2 in pathogenesi s of dermatomyositis. (PubMed id 22281496) 1 Ogata A....Oike Y. (2012)
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External Searches for ANGPTL2 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing ANGPTL2 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing ANGPTL2 gene
(According to HUGE )
About This Section --
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Specialized Databases showing ANGPTL2 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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About This Section Patent Information for ANGPTL2 gene: Search GeneIP for patents involving ANGPTL2 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor ANGPTL2 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for ANGPTL2 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for ANGPTL2 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for ANGPTL2 OriGene Protein Over-expression Lysate for ANGPTL2 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for ANGPTL2 OriGene 3'-UTR Clone for ANGPTL2 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for ANGPTL2 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for ANGPTL2 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for ANGPTL2 OriGene Custom Protein Services for ANGPTL2 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ANGPTL2 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing ANGPTL2 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ANGPTL2 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat ANGPTL2 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat ANGPTL2 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat ANGPTL2
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ANGPTL2 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANGPTL2
ThermoFisher Antibodies for ANGPTL2
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat ANGPTL2
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