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Aliases for ANGPTL1 Gene

Aliases for ANGPTL1 Gene

  • Angiopoietin Like 1 2 3 5
  • Angiopoietin-Like Protein 1 3 4
  • Angiopoietin-Like 1 2 3
  • Angiopoietin-3 3 4
  • Angioarrestin 2 3
  • ANGPT3 3 4
  • ANG-3 3 4
  • ARP1 3 4
  • ANG3 3 4
  • DJ595C2.2 (Angiopoietin Y1) 3
  • Angiopoietin Y1 3
  • Angiopoietin 3 3
  • DJ595C2.2 3
  • UNQ162 3
  • AngY 3

External Ids for ANGPTL1 Gene

Previous HGNC Symbols for ANGPTL1 Gene

  • ANGPT3

Previous GeneCards Identifiers for ANGPTL1 Gene

  • GC01M176344
  • GC01M174248
  • GC01M175400
  • GC01M176059
  • GC01M176060
  • GC01M175551
  • GC01M177085
  • GC01M150047

Summaries for ANGPTL1 Gene

Entrez Gene Summary for ANGPTL1 Gene

  • Angiopoietins are members of the vascular endothelial growth factor family and the only known growth factors largely specific for vascular endothelium. Angiopoietin-1, angiopoietin-2, and angiopoietin-4 participate in the formation of blood vessels. The protein encoded by this gene is another member of the angiopoietin family that is widely expressed in adult tissues with mRNA levels highest in highly vascularized tissues. This protein was found to be a secretory protein that does not act as an endothelial cell mitogen in vitro. [provided by RefSeq, Jul 2008]

GeneCards Summary for ANGPTL1 Gene

ANGPTL1 (Angiopoietin Like 1) is a Protein Coding gene. Among its related pathways are ERK Signaling and Akt Signaling. GO annotations related to this gene include receptor binding. An important paralog of this gene is FGB.

Gene Wiki entry for ANGPTL1 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANGPTL1 Gene

Genomics for ANGPTL1 Gene

Regulatory Elements for ANGPTL1 Gene

Genomic Location for ANGPTL1 Gene

Chromosome:
1
Start:
178,849,535 bp from pter
End:
178,871,353 bp from pter
Size:
21,819 bases
Orientation:
Minus strand

Genomic View for ANGPTL1 Gene

Genes around ANGPTL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANGPTL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANGPTL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANGPTL1 Gene

Proteins for ANGPTL1 Gene

  • Protein details for ANGPTL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95841-ANGL1_HUMAN
    Recommended name:
    Angiopoietin-related protein 1
    Protein Accession:
    O95841
    Secondary Accessions:
    • Q5T5Z5

    Protein attributes for ANGPTL1 Gene

    Size:
    491 amino acids
    Molecular mass:
    56720 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ANGPTL1 Gene

Proteomics data for ANGPTL1 Gene at MOPED

Post-translational modifications for ANGPTL1 Gene

  • Glycosylation at Asn 160 and Asn 188
  • Modification sites at PhosphoSitePlus

Other Protein References for ANGPTL1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for ANGPTL1 (Angiopoietin-like Protein 1/ANGPTL1)

No data available for DME Specific Peptides for ANGPTL1 Gene

Domains & Families for ANGPTL1 Gene

Gene Families for ANGPTL1 Gene

Suggested Antigen Peptide Sequences for ANGPTL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O95841

UniProtKB/Swiss-Prot:

ANGL1_HUMAN :
  • Contains 1 fibrinogen C-terminal domain.
Domain:
  • Contains 1 fibrinogen C-terminal domain.
genes like me logo Genes that share domains with ANGPTL1: view

Function for ANGPTL1 Gene

Phenotypes for ANGPTL1 Gene

GenomeRNAi human phenotypes for ANGPTL1:
MGI mutant phenotypes for ANGPTL1:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with ANGPTL1: view

Animal Models for ANGPTL1 Gene

MGI Knock Outs for ANGPTL1:

Animal Model Products

CRISPR Products

miRNA for ANGPTL1 Gene

miRTarBase miRNAs that target ANGPTL1

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ANGPTL1 Gene

Localization for ANGPTL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ANGPTL1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ANGPTL1 Gene COMPARTMENTS Subcellular localization image for ANGPTL1 gene
Compartment Confidence
extracellular 5
mitochondrion 2
cytosol 1
endoplasmic reticulum 1
peroxisome 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for ANGPTL1 Gene

Pathways & Interactions for ANGPTL1 Gene

genes like me logo Genes that share pathways with ANGPTL1: view

Pathways by source for ANGPTL1 Gene

1 GeneGo (Thomson Reuters) pathway for ANGPTL1 Gene

SIGNOR curated interactions for ANGPTL1 Gene

Activates:
Inactivates:

Gene Ontology (GO) - Biological Process for ANGPTL1 Gene

None

Drugs & Compounds for ANGPTL1 Gene

(1) Drugs for ANGPTL1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with ANGPTL1: view

Transcripts for ANGPTL1 Gene

Unigene Clusters for ANGPTL1 Gene

Angiopoietin-like 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ANGPTL1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8
SP1:
SP2:
SP3:
SP4: - -

Relevant External Links for ANGPTL1 Gene

GeneLoc Exon Structure for
ANGPTL1
ECgene alternative splicing isoforms for
ANGPTL1

Expression for ANGPTL1 Gene

mRNA expression in normal human tissues for ANGPTL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ANGPTL1 Gene

This gene is overexpressed in Artery - Tibial (x4.1).

Protein differential expression in normal tissues from HIPED for ANGPTL1 Gene

This gene is overexpressed in Vitreous humor (51.6) and Ovary (11.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ANGPTL1 Gene



SOURCE GeneReport for Unigene cluster for ANGPTL1 Gene Hs.591474

mRNA Expression by UniProt/SwissProt for ANGPTL1 Gene

O95841-ANGL1_HUMAN
Tissue specificity: Highly expressed in adrenal gland, placenta, thyroid gland, heart, skeletal muscle and small intestine. Weakly expressed in testis, ovary, colon, pancreas, kidney and stomach.
genes like me logo Genes that share expression patterns with ANGPTL1: view

Primer Products

In Situ Assay Products

No data available for Protein tissue co-expression partners for ANGPTL1 Gene

Orthologs for ANGPTL1 Gene

This gene was present in the common ancestor of animals.

Orthologs for ANGPTL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ANGPTL1 36
  • 99 (a)
OneToOne
ANGPTL1 35
  • 99.39 (n)
  • 99.39 (a)
cow
(Bos Taurus)
Mammalia ANGPTL1 35
  • 91.85 (n)
  • 95.11 (a)
ANGPTL1 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ANGPTL1 36
  • 96 (a)
OneToOne
ANGPTL1 35
  • 93.28 (n)
  • 95.52 (a)
mouse
(Mus musculus)
Mammalia Angptl1 16
Angptl1 36
  • 93 (a)
OneToOne
Angptl1 35
  • 88.71 (n)
  • 93.06 (a)
oppossum
(Monodelphis domestica)
Mammalia ANGPTL1 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ANGPTL1 36
  • 92 (a)
OneToOne
chicken
(Gallus gallus)
Aves ANGPTL1 35
  • 79.21 (n)
  • 84.87 (a)
ANGPTL1 36
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ANGPTL1 36
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia angptl1 35
  • 71.75 (n)
  • 76.7 (a)
zebrafish
(Danio rerio)
Actinopterygii angptl1 35
  • 63.37 (n)
  • 65.89 (a)
angptl1 36
  • 65 (a)
OneToMany
ANGPTL1 (1 of 2) 36
  • 52 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta BG:DS00929.7 37
  • 44 (a)
CG10359 37
  • 41 (a)
CG1791 37
  • 40 (a)
CG1889 37
  • 36 (a)
CG30280 37
  • 40 (a)
CG30281 37
  • 40 (a)
CG5550 37
  • 36 (a)
CG8642 37
  • 41 (a)
CG9500 37
  • 37 (a)
sca 37
  • 27 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 42 (a)
OneToMany
Species with no ortholog for ANGPTL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ANGPTL1 Gene

ENSEMBL:
Gene Tree for ANGPTL1 (if available)
TreeFam:
Gene Tree for ANGPTL1 (if available)

Paralogs for ANGPTL1 Gene

Paralogs for ANGPTL1 Gene

(9) SIMAP similar genes for ANGPTL1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ANGPTL1: view

Variants for ANGPTL1 Gene

Structural Variations from Database of Genomic Variants (DGV) for ANGPTL1 Gene

Variant ID Type Subtype PubMed ID
nsv525444 CNV Loss 19592680
nsv466206 CNV Gain 19166990
nsv470748 CNV Gain 18288195
nsv872572 CNV Loss 21882294
nsv3710 CNV Insertion 18451855

Variation tolerance for ANGPTL1 Gene

Residual Variation Intolerance Score: 42% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.77; 33.53% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ANGPTL1 Gene

HapMap Linkage Disequilibrium report
ANGPTL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for ANGPTL1 Gene

Disorders for ANGPTL1 Gene

Relevant External Links for ANGPTL1

Genetic Association Database (GAD)
ANGPTL1
Human Genome Epidemiology (HuGE) Navigator
ANGPTL1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ANGPTL1

No disorders were found for ANGPTL1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANGPTL1 Gene

Publications for ANGPTL1 Gene

  1. Molecular cloning and characterization of a novel angiopoietin family protein, angiopoietin-3. (PMID: 10025962) Kim I. … Koh G.Y. (FEBS Lett. 1999) 2 3 4 23 67
  2. Recombinant angioarrestin secreted from mouse melanoma cells inhibits growth of primary tumours. (PMID: 15940350) Smagur A. … Szala S. (Acta Biochim. Pol. 2005) 3 23
  3. Angioarrestin: a unique angiopoietin-related protein with anti-angiogenic properties. (PMID: 15950186) Dhanabal M. … Lichenstein H.S. (Biochem. Biophys. Res. Commun. 2005) 3 23
  4. Construction of a 1.2-Mb sequence-ready contig of chromosome 11q13 encompassing the multiple endocrine neoplasia type 1 (MEN1) gene. The European Consortium on MEN1. (PMID: 9286704) Lemmens I. … Thakker R.V. (Genomics 1997) 2 3
  5. Differential effects of Tat proteins derived from HIV-1 subtypes B and recombinant CRF02_AG on human brain microvascular endothelial cells: implications for blood-brain barrier dysfunction. (PMID: 24667918) Woollard S.M. … Kanmogne G.D. (J. Cereb. Blood Flow Metab. 2014) 3

Products for ANGPTL1 Gene

Sources for ANGPTL1 Gene

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