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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ANGPTL1 Gene

protein-coding   GIFtS: 60
GCID: GC01M178818

angiopoietin-like 1


(Previous symbol: ANGPT3)
 Explore 4 diseases affiliated with
ANGPTL1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ANGPTL1    

Aliases
for ANGPTL1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Angiopoietin-Like 11 2     Angioarrestin1
ANG31 2 3     Angiopoietin 32
ANGPT31 2 3     Angiopoietin Y12
ARP11 2 3     Angiopoietin-33
AngY1 2     Angiopoietin-Related Protein 12
Angiopoietin-Like Protein 12 3     DJ595C2.21
ANG-32 3     DJ595C2.2 (Angiopoietin Y1)2
UNQ1622     Angiopoietin-33

External Ids:    HGNC: 4891   Entrez Gene: 90682   Ensembl: ENSG000001161947   OMIM: 6038745   UniProtKB: O958413   

Export aliases for ANGPTL1 gene to outside databases

Previous GC identifers: GC01M176344 GC01M174248 GC01M175400 GC01M176059 GC01M176060 GC01M175551 GC01M177085 GC01M150047


Summaries
for ANGPTL1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for ANGPTL1:
Angiopoietins are members of the vascular endothelial growth factor family and the only known growth factors largely
specific for vascular endothelium. Angiopoietin-1, angiopoietin-2, and angiopoietin-4 participate in the formation of
blood vessels. The protein encoded by this gene is another member of the angiopoietin family that is widely expressed
in adult tissues with mRNA levels highest in highly vascularized tissues. This protein was found to be a secretory
protein that does not act as an endothelial cell mitogen in vitro. (provided by RefSeq, Jul 2008)

Gene Wiki entry for ANGPTL1


Genomic Views
for ANGPTL1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_004487.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ANGPTL1 gene promoter:
         HFH-3   GR   HNF-3beta   FOXL1   MEF-2A   FOXI1   Nkx6-1   STAT3   aMEF-2   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ANGPTL1 promoter sequence
   Search SABiosciences Chromatin IP Primers for ANGPTL1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ANGPTL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q25.2   Ensembl cytogenetic band:  1q25.2   HGNC cytogenetic band: 1q25.2

ANGPTL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ANGPTL1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M178818:  view genomic region     (about GC identifiers)

Start:
 178,818,670 bp from pter      End:
 178,840,215 bp from pter
Size:
 21,546 bases      Orientation:
 minus strand

Proteins
for ANGPTL1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ANGL1_HUMAN, O95841 (See protein sequence)
Recommended Name: Angiopoietin-related protein 1 precursor  
Size: 491 amino acids; 56720 Da
Subcellular location: Secreted
Secondary accessions: Q5T5Z5

Explore the universe of human proteins at neXtProt for ANGPTL1: NX_O95841

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O95841

    • ANGPTL1 Protein expression data from MOPED and PaxDb:    About this image 
    ANGPTL1 Protein Expression
    REFSEQ proteins: NP_004664.1  
    ENSEMBL proteins: 
     ENSP00000234816   ENSP00000356601   ENSP00000392023   ENSP00000393375  

    Human Recombinant Protein Products for ANGPTL1: 
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    Novus Biologicals ANGPTL1 Protein
    Novus Biologicals ANGPTL1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for ANGPTL1

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IDA10025962

    ANGPTL1 for ontologies           About GeneDecksing



    ANGPTL1 Antibody Products: 
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    Uscn ELISAs and CLIAs for ANGPTL1

    Protein Domains /
    Families
    for ANGPTL1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ANGPTL1 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR020837 Fibrinogen_CS
     IPR014715 Fibrinogen_a/b/g_C_2
     IPR002181 Fibrinogen_a/b/g_C_dom
     IPR014716 Fibrinogen_a/b/g_C_1

    Graphical View of Domain Structure for InterPro Entry O95841

    ProtoNet protein and cluster: O95841

    1 Blocks protein family: IPB002181 Fibrinogen

    UniProtKB/Swiss-Prot: ANGL1_HUMAN, O95841
    Similarity: Contains 1 fibrinogen C-terminal domain


    Function
    for ANGPTL1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding IEA--
         
    ANGPTL1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for ANGPTL1:
     G0/1 arrest  Increased G1 DNA content 

         1 MGI mutant phenotype (inferred from 2 alleles) (MGI details for Angptl1):
     normal 

    ANGPTL1 for phenotypes           About GeneDecksing

    Animal Models:
         Mouse knock-out Angptl1tm1Lex for ANGPTL1
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for ANGPTL1 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ANGPTL1
    8/22 QIAGEN miScript miRNA Assays for microRNAs that regulate ANGPTL1 (see all 22):
    hsa-miR-411* hsa-miR-320a hsa-miR-379* hsa-miR-4272 hsa-miR-340 hsa-miR-570 hsa-miR-1323 hsa-miR-186
    SwitchGear 3'UTR luciferase reporter plasmid: ANGPTL1 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ANGPTL1 (see all 7)
    OriGene shRNA RFP: ANGPTL1
    OriGene siRNA: ANGPTL1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ANGPTL1
    Sirion Biotech Custom design and validation of potent shRNA sequences against ANGPTL1 

    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of ANGPTL1 
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    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ANGPTL1 (see all 3)
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    GenScript: all cDNA clones in your preferred vector: ANGPTL1 (NM_004673)
    Sino Biological Human cDNA Clone for ANGPTL1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ANGPTL1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ANGPTL1 

    Cell Line
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    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANGPTL1


    Pathways & Interactions
    for ANGPTL1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1PEDF Induced Signaling
    8/11 pathways (see all 11)
    		PEDF Induced Signaling1.00
    		STAT3 Pathway0.47
    		MIF Mediated Glucocorticoid Regulation0.73
    		Endothelin-1 Signaling Pathway0.44
    		MIF Regulation of Innate Immune Cells0.71
    		NFAT Signaling and Lymphocyte Interactions0.37
    		IL-6 Pathway0.61
    		PGC1Alpha Pathway0.33
    2TGF-Beta Pathway
    		TGF-Beta Pathway1.00
    		JNK Pathway0.50
    		MAPK Family Pathway0.60
    		Regulation of eIF4 and p70S6K0.43
    		JAK-STAT Pathway0.57
    		SOCS Pathway0.29
    3Akt Signaling
    		Akt Signaling1.00
    		Tec Kinases Signaling0.55
    		p38 Signaling0.60
    4Rho Family GTPases
    		Rho Family GTPases1.00
    		Molecular Mechanisms of Cancer0.51
    		ERK Signaling0.61
    5Development_PDGF signaling via STATs and NF-kB
    		Development_Angiopoietin - Tie2 signaling0.38
    		Angiopoietin-TIE2 Signaling0.13
    		Development Angiopoietin - Tie2 signaling0.38

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for ANGPTL1
        Development Angiopoietin - Tie2 signaling

    5/26 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for ANGPTL1 (see all 26)
        Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    NFAT Signaling and Lymphocyte Interactions
    JNK Pathway

    1 GeneGo (Thomson Reuters) Pathway for ANGPTL1
        Development Angiopoietin - Tie2 signaling



    ANGPTL1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ANGPTL1

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    5 Interacting proteins for ANGPTL1 (O958413 ENSP000002348164) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TEKQ027633, ENSP000003839774I2D: score=2 STRING: ENSP00000383977
    NR2F6P105883, ENSP000002914424I2D: score=1 STRING: ENSP00000291442
    PDPK1O155303I2D: score=1 
    PRKAA1Q131313I2D: score=1 
    TIE1ENSP000003615544STRING: ENSP00000361554
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007169transmembrane receptor protein tyrosine kinase signaling pathway IEA--

    ANGPTL1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for ANGPTL1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ANGPTL1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ANGPTL1
    1 Novoseek chemical compound relationship for ANGPTL1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 21.7 1 15342395 (1)

    Search CenterWatch for drugs/clinical trials and news about ANGPTL1 / ANGL1 

    Transcripts
    for ANGPTL1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ANGPTL1 gene: 
    NM_004673.3  

    Unigene Cluster for ANGPTL1:

    Angiopoietin-like 1
    Hs.591474  [show with all ESTs]
    Unigene Representative Sequence: NM_004673
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000234816(uc010pnc.1 uc001gma.3 uc001gmb.3) ENST00000367629
    ENST00000444255 ENST00000415564

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ANGPTL1
    8/22 QIAGEN miScript miRNA Assays for microRNAs that regulate ANGPTL1 (see all 22):
    hsa-miR-411* hsa-miR-320a hsa-miR-379* hsa-miR-4272 hsa-miR-340 hsa-miR-570 hsa-miR-1323 hsa-miR-186
    SwitchGear 3'UTR luciferase reporter plasmid: ANGPTL1 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ANGPTL1 (see all 7)
    OriGene shRNA RFP: ANGPTL1
    OriGene siRNA: ANGPTL1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ANGPTL1
    Sirion Biotech Custom design and validation of potent shRNA sequences against ANGPTL1 
    Clone
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    GenScript: all cDNA clones in your preferred vector: ANGPTL1 (NM_004673)
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    Primer
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    Additional cDNA sequence: 

    AB056476.1 AF086266.1 AF107253.1 AK223467.1 AK300218.1 AY358278.1 BC047670.1 BC050640.1 

    4 DOTS entries:

    DT.100758324  DT.121429248  DT.121429253  DT.86844047 

    24/89 AceView cDNA sequences (see all 89):

    BC050640 NM_004673 AI001937 AF107253 AI927629 AI381675 AA131275 BP372640 
    CD722776 AB056476 BI523583 BU753998 AI376255 BX378529 CR621065 AF086266 
    BC047670 BM671294 BG206992 BG189452 BX500730 AI382419 AI221187 BX490031 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for ANGPTL1    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8
    SP1:                                                                  
    SP2:                                                                  
    SP3:                                                                  
    SP4:        -     -                                                   


    ECgene alternative splicing isoforms for ANGPTL1

    Expression
    for ANGPTL1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ANGPTL1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTCAAGATAC
    ANGPTL1 Expression
    About this image

    ANGPTL1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    6 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BoneThoracic RibBone
    BoneZeugopod Epiphyseal EndBone
    BoneZeugopod Growth PlateBone
    LimbAutopodLimb
    LimbStylopodLimb
    LimbZeugopodLimb
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Cartilage-like cells (Differentiation of s...)Cartilage

    See ANGPTL1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ANGPTL1

    SOURCE GeneReport for Unigene cluster: Hs.591474

    UniProtKB/Swiss-Prot: ANGL1_HUMAN, O95841
    Tissue specificity: Highly expressed in adrenal gland, placenta, thyroid gland, heart, skeletal muscle and small
    intestine. Weakly expressed in testis, ovary, colon, pancreas, kidney and stomach

        SABiosciences Expression via Pathway-Focused PCR Array including ANGPTL1: 
              Angiogenic Growth Factors in human mouse rat

    Primer
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    In Situ
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         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANGPTL1

    Orthologs
    for ANGPTL1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for ANGPTL1 gene from 3/11 species (see all 11)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves ANGPTL11 angiopoietin-like 1 79.21(n)
    84.87(a)    		   770850  XM_001233149.2  XP_001233150.1 
    lizard
    (Anolis carolinensis)    		 Reptilia ANGPTL16
    		 --
    		 84(a)
    		 1 ↔ 1
    		 GL343300.1(643467-656643)
    zebrafish
    (Danio rerio)    		 Actinopterygii angptl11 angiopoietin-like 1 63.3(n)
    65.89(a)    		   544656  NM_001014820.1  NP_001014820.1 


    ENSEMBL Gene Tree for ANGPTL1 (if available)
    TreeFam Gene Tree for ANGPTL1 (if available) 

    Paralogs
    for ANGPTL1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ANGPTL1 gene
    FGL22  ANGPT42  FGA2  FGG2  ANGPTL62  ANGPTL22  ANGPTL42  ANGPT12  
    ANGPTL32  ANGPTL72  FGB2  ANGPT22  FGL12  
    10 SIMAP similar genes for ANGPTL1 using alignment to 2 protein entries:     ANGL1_HUMAN (see all proteins):
    ANGPTL2    ANGPTL7    FGL1    LFIRE1    ANGPT1    ANGPTL6
    FCN3    FIBCD1    ANGPT4    ANGPT2

    ANGPTL1 for paralogs           About GeneDecksing



    Genomic Variants
    for ANGPTL1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/425 NCBI SNPs in ANGPTL1 are shown (see all 425)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1469276561,2
    		--178818248(+) ACAAAA/TACCAC 2 -- ds5001 int10--------
    rs767418171,2
    		C--178818409(+) ATACCG/ACNNNN 2 -- int1 ds50013Minor allele frequency- A:0.05CSA WA NA 240
    rs797148291,2
    		F--178818477(+) AGAGTA/GAAATA 2 -- ds5001 int11Minor allele frequency- G:0.13WA 118
    rs1454161881,2
    		--178818556(+) CCAAG-/GT    
       TGTAT    GTTGA     		2 -- ds5001 int10--------
    rs1830656411,2
    		--178818616(+) GTAAGA/GCTTGT 2 -- ds5001 int10--------
    rs1475967401,2
    		--178818652(+) ATGAAA/GTGATA 2 -- ds5001 int10--------
    rs1420860191,2
    		--178818737(+) GTTCCC/TTCCAG 2 -- ut31 int10--------
    rs1997058621,2
    		--178818754(+) ATAAC-/AAGATT 2 -- int1 ut310--------
    rs1166100981,2
    		F--178818774(+) TGAAGG/CAAGTG 2 -- int1 ut311Minor allele frequency- C:0.03NA 120
    rs1877453021,2
    		--178818803(+) AGTTTA/CAGATG 2 -- ut31 int10--------

    HapMap Linkage Disequilibrium report for ANGPTL1 (178818670 - 178840215 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for ANGPTL1: --

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for ANGPTL1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ANGPTL1 for disorders           About GeneDecksing

    OMIM gene information: 603874    OMIM disorders: --

    4 diseases for ANGPTL1:    About MalaCards
    multiple endocrine neoplasia    melanoma    lung cancer    thyroiditis

    2 Novoseek disease relationships for ANGPTL1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    melanoma 19.5 3 15940350 (3)
    tumors 0 10 15342395 (3), 15950186 (1)

    Human Genome Epidemiology (HuGE) Navigator: ANGPTL1 (1 document)

    Export disorders for ANGPTL1 gene to outside databases

    Publications
    for ANGPTL1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ANGPTL1 gene, integrated from 9 sources (see all 28):
    (articles sorted by number of sources associating them with ANGPTL1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and characterization of a novel angiopoietin family protein, angiopoietin-3. (PubMed id 10025962)1, 2, 3, 9 Kim I.... Koh G.Y. (1999)
    2. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    3. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1, 2 Otsuki T....Isogai T. (2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Construction of a 1.2-Mb sequence-ready contig of chromosome 11q13 encompassing the multiple endocrine neoplasia type 1 (MEN1) gene. The European Consortium on MEN1. (PubMed id 9286704)1, 3 Lemmens I....Thakker R.V. (1997)
    6. Recombinant angioarrestin secreted from mouse melanoma cells inhibits growth of primary tumours. (PubMed id 15940350)1, 9 Smagur A....Szala S. (2005)
    7. Angioarrestin: a unique angiopoietin-related protein with anti-angiogenic properties. (PubMed id 15950186)1, 9 Dhanabal M....Lichenstein H.S. (2005)
    8. MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage he ad and neck cancer. (PubMed id 20819778)1 Zhang X....Wu X. (2010)
    9. Metalloproteinases, vascular endothelial growth facto r, and angiopoietin 1 and 2 in eutopic and ectopic endometrium. (PubMed id 18644593)1 Di Carlo C....Nappi C. (2009)
    10. Balance between angiopoietin-1 and angiopoietin-2 is in favor of angiopoietin-2 in atherosclerotic plaques with high microvessel density. (PubMed id 18182823)1 Post S....Vink A. (2008)

    External Searches for ANGPTL1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing ANGPTL1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9068 HGNC: 489 AceView: ANGPTL1 Ensembl:ENSG00000116194 euGenes: HUgn9068
    ECgene: ANGPTL1 H-InvDB: ANGPTL1

    Other Databases showing ANGPTL1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ANGPTL1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ANGPTL1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ANGPTL1 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for ANGPTL1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ANGPTL1 gene:
    Search GeneIP for patents involving ANGPTL1

    GeneCards and IP:
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    About This Section

     
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