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Aliases for ANGPTL1 Gene

Aliases for ANGPTL1 Gene

  • Angiopoietin-Like 1 2 3
  • Angiopoietin-Like Protein 1 3 4
  • Angiopoietin-3 3 4
  • Angioarrestin 2 3
  • ANGPT3 3 4
  • ANG-3 3 4
  • Arp1 3 4
  • ANG3 3 4
  • Angiopoietin-Related Protein 1 3
  • DJ595C2.2 (Angiopoietin Y1) 3
  • Angiopoietin Y1 3
  • Angiopoietin 3 3
  • DJ595C2.2 3
  • UNQ162 3
  • AngY 3

External Ids for ANGPTL1 Gene

Previous HGNC Symbols for ANGPTL1 Gene

  • ANGPT3

Previous GeneCards Identifiers for ANGPTL1 Gene

  • GC01M176344
  • GC01M174248
  • GC01M175400
  • GC01M176059
  • GC01M176060
  • GC01M175551
  • GC01M177085
  • GC01M150047

Summaries for ANGPTL1 Gene

Entrez Gene Summary for ANGPTL1 Gene

  • Angiopoietins are members of the vascular endothelial growth factor family and the only known growth factors largely specific for vascular endothelium. Angiopoietin-1, angiopoietin-2, and angiopoietin-4 participate in the formation of blood vessels. The protein encoded by this gene is another member of the angiopoietin family that is widely expressed in adult tissues with mRNA levels highest in highly vascularized tissues. This protein was found to be a secretory protein that does not act as an endothelial cell mitogen in vitro. [provided by RefSeq, Jul 2008]

GeneCards Summary for ANGPTL1 Gene

ANGPTL1 (Angiopoietin-Like 1) is a Protein Coding gene. Among its related pathways are TGF-Beta Pathway and TGF-Beta Pathway. GO annotations related to this gene include receptor binding. An important paralog of this gene is FIBCD1.

Gene Wiki entry for ANGPTL1 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANGPTL1 Gene

Genomics for ANGPTL1 Gene

Regulatory Elements for ANGPTL1 Gene

Genomic Location for ANGPTL1 Gene

Start:
178,849,535 bp from pter
End:
178,871,236 bp from pter
Size:
21,702 bases
Orientation:
Minus strand

Genomic View for ANGPTL1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ANGPTL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANGPTL1 Gene

Proteins for ANGPTL1 Gene

  • Protein details for ANGPTL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95841-ANGL1_HUMAN
    Recommended name:
    Angiopoietin-related protein 1
    Protein Accession:
    O95841
    Secondary Accessions:
    • Q5T5Z5

    Protein attributes for ANGPTL1 Gene

    Size:
    491 amino acids
    Molecular mass:
    56720 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ANGPTL1 Gene

Proteomics data for ANGPTL1 Gene at MOPED

Post-translational modifications for ANGPTL1 Gene

  • Glycosylation at Asn160 and Asn188
  • Modification sites at PhosphoSitePlus

Other Protein References for ANGPTL1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for ANGPTL1 (Angiopoietin-like Protein 1/ANGPTL1)

No data available for DME Specific Peptides for ANGPTL1 Gene

Domains for ANGPTL1 Gene

Gene Families for ANGPTL1 Gene

HGNC:
  • FIBC :Fibrinogen C domain containing

Suggested Antigen Peptide Sequences for ANGPTL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O95841

UniProtKB/Swiss-Prot:

ANGL1_HUMAN :
  • O95841
Domain:
  • Contains 1 fibrinogen C-terminal domain.
genes like me logo Genes that share domains with ANGPTL1: view

Function for ANGPTL1 Gene

Gene Ontology (GO) - Molecular Function for ANGPTL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding IEA --
genes like me logo Genes that share ontologies with ANGPTL1: view

Phenotypes for ANGPTL1 Gene

MGI mutant phenotypes for ANGPTL1:
inferred from 1 alleles
GenomeRNAi human phenotypes for ANGPTL1:
genes like me logo Genes that share phenotypes with ANGPTL1: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ANGPTL1 Gene

Localization for ANGPTL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ANGPTL1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ANGPTL1 Gene COMPARTMENTS Subcellular localization image for ANGPTL1 gene
Compartment Confidence
extracellular 5
mitochondrion 2
cytosol 1
endoplasmic reticulum 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for ANGPTL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 10025962
GO:0070062 extracellular exosome IDA 19199708
genes like me logo Genes that share ontologies with ANGPTL1: view

Pathways for ANGPTL1 Gene

genes like me logo Genes that share pathways with ANGPTL1: view

Pathways by source for ANGPTL1 Gene

1 GeneGo (Thomson Reuters) pathway for ANGPTL1 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for ANGPTL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IEA --
genes like me logo Genes that share ontologies with ANGPTL1: view

Compounds for ANGPTL1 Gene

(1) Novoseek inferred chemical compound relationships for ANGPTL1 Gene

Compound -log(P) Hits PubMed IDs
tyrosine 21.7 1
genes like me logo Genes that share compounds with ANGPTL1: view

Transcripts for ANGPTL1 Gene

Unigene Clusters for ANGPTL1 Gene

Angiopoietin-like 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ANGPTL1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ANGPTL1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8
SP1:
SP2:
SP3:
SP4: - -

Relevant External Links for ANGPTL1 Gene

GeneLoc Exon Structure for
ANGPTL1
ECgene alternative splicing isoforms for
ANGPTL1

Expression for ANGPTL1 Gene

mRNA expression in normal human tissues for ANGPTL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ANGPTL1 Gene

This gene is overexpressed in Artery - Tibial (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ANGPTL1 Gene

SOURCE GeneReport for Unigene cluster for ANGPTL1 Gene Hs.591474

mRNA Expression by UniProt/SwissProt for ANGPTL1 Gene

O95841-ANGL1_HUMAN
Tissue specificity: Highly expressed in adrenal gland, placenta, thyroid gland, heart, skeletal muscle and small intestine. Weakly expressed in testis, ovary, colon, pancreas, kidney and stomach.
genes like me logo Genes that share expressions with ANGPTL1: view

In Situ Assay Products

Orthologs for ANGPTL1 Gene

This gene was present in the common ancestor of animals.

Orthologs for ANGPTL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ANGPTL1 35
  • 99.39 (n)
  • 99.39 (a)
ANGPTL1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ANGPTL1 35
  • 91.85 (n)
  • 95.11 (a)
ANGPTL1 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ANGPTL1 35
  • 93.28 (n)
  • 95.52 (a)
ANGPTL1 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Angptl1 35
  • 88.71 (n)
  • 93.06 (a)
Angptl1 16
Angptl1 36
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ANGPTL1 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ANGPTL1 36
  • 92 (a)
OneToOne
chicken
(Gallus gallus)
Aves ANGPTL1 35
  • 79.21 (n)
  • 84.87 (a)
ANGPTL1 36
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ANGPTL1 36
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia angptl1 35
  • 71.75 (n)
  • 76.7 (a)
zebrafish
(Danio rerio)
Actinopterygii angptl1 35
  • 63.37 (n)
  • 65.89 (a)
angptl1 36
  • 65 (a)
OneToMany
ANGPTL1 (1 of 2) 36
  • 52 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta BG:DS00929.7 37
  • 44 (a)
CG10359 37
  • 41 (a)
CG1889 37
  • 36 (a)
CG30281 37
  • 40 (a)
CG1791 37
  • 40 (a)
CG8642 37
  • 41 (a)
sca 37
  • 27 (a)
CG30280 37
  • 40 (a)
CG9500 37
  • 37 (a)
CG5550 37
  • 36 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 42 (a)
OneToMany
Species with no ortholog for ANGPTL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ANGPTL1 Gene

ENSEMBL:
Gene Tree for ANGPTL1 (if available)
TreeFam:
Gene Tree for ANGPTL1 (if available)

Paralogs for ANGPTL1 Gene

Selected SIMAP similar genes for ANGPTL1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ANGPTL1: view

Variants for ANGPTL1 Gene

Structural Variations from Database of Genomic Variants (DGV) for ANGPTL1 Gene

Variant ID Type Subtype PubMed ID
nsv525444 CNV Loss 19592680
nsv466206 CNV Gain 19166990
nsv470748 CNV Gain 18288195
nsv872572 CNV Loss 21882294
nsv3710 CNV Insertion 18451855

Relevant External Links for ANGPTL1 Gene

HapMap Linkage Disequilibrium report
ANGPTL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for ANGPTL1 Gene

Disorders for ANGPTL1 Gene

(2) Novoseek inferred disease relationships for ANGPTL1 Gene

Disease -log(P) Hits PubMed IDs
melanoma 19.5 3
tumors 0 4

Relevant External Links for ANGPTL1

Genetic Association Database (GAD)
ANGPTL1
Human Genome Epidemiology (HuGE) Navigator
ANGPTL1
genes like me logo Genes that share disorders with ANGPTL1: view

No data available for UniProtKB/Swiss-Prot for ANGPTL1 Gene

Publications for ANGPTL1 Gene

  1. Molecular cloning and characterization of a novel angiopoietin family protein, angiopoietin-3. (PMID: 10025962) Kim I. … Koh G.Y. (FEBS Lett. 1999) 2 3 4 23
  2. Recombinant angioarrestin secreted from mouse melanoma cells inhibits growth of primary tumours. (PMID: 15940350) Smagur A. … Szala S. (Acta Biochim. Pol. 2005) 3 23
  3. Angioarrestin: a unique angiopoietin-related protein with anti-angiogenic properties. (PMID: 15950186) Dhanabal M. … Lichenstein H.S. (Biochem. Biophys. Res. Commun. 2005) 3 23
  4. Construction of a 1.2-Mb sequence-ready contig of chromosome 11q13 encompassing the multiple endocrine neoplasia type 1 (MEN1) gene. The European Consortium on MEN1. (PMID: 9286704) Lemmens I. … Thakker R.V. (Genomics 1997) 2 3
  5. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3 4

Products for ANGPTL1 Gene

Sources for ANGPTL1 Gene

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