Aliases for ANGPTL1 Gene
Aliases for ANGPTL1 Gene
External Ids for ANGPTL1 Gene
- HGNC: 489
- Entrez Gene: 9068
- Ensembl: ENSG00000116194
- OMIM: 603874
- UniProtKB: O95841
Previous HGNC Symbols for ANGPTL1 Gene
- ANGPT3
Previous GeneCards Identifiers for ANGPTL1 Gene
- GC01M176344
- GC01M174248
- GC01M175400
- GC01M176059
- GC01M176060
- GC01M175551
- GC01M177085
- GC01M150047
Summaries for ANGPTL1 Gene
-
Angiopoietins are members of the vascular endothelial growth factor family and the only known growth factors largely specific for vascular endothelium. Angiopoietin-1, angiopoietin-2, and angiopoietin-4 participate in the formation of blood vessels. The protein encoded by this gene is another member of the angiopoietin family that is widely expressed in adult tissues with mRNA levels highest in highly vascularized tissues. This protein was found to be a secretory protein that does not act as an endothelial cell mitogen in vitro. [provided by RefSeq, Jul 2008]
GeneCards Summary for ANGPTL1 Gene
ANGPTL1 (Angiopoietin Like 1) is a Protein Coding gene. Among its related pathways are Akt Signaling and PEDF Induced Signaling. GO annotations related to this gene include receptor binding. An important paralog of this gene is FGB.
No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANGPTL1 Gene
Genomics for ANGPTL1 Gene
Regulatory Elements for ANGPTL1 Gene
Enhancers for ANGPTL1 Gene
| GeneHancer Identifier | Score | Enhancer Sources | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Other Gene Targets for Enhancer |
|---|
Enhancers around ANGPTL1 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for ANGPTL1 Gene
- Chromosome:
- 1
- Start:
- 178,849,535 bp from pter
- End:
- 178,871,353 bp from pter
- Size:
- 21,819 bases
- Orientation:
- Minus strand
Genomic View for ANGPTL1 Gene
Genes around ANGPTL1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1q25.2 by Ensembl
- 1q25.2 by Entrez Gene
- 1q25.2 by HGNC
ANGPTL1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ANGPTL1 Gene
Proteins for ANGPTL1 Gene
-
Protein details for ANGPTL1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O95841-ANGL1_HUMAN
- Recommended name:
- Angiopoietin-related protein 1
- Protein Accession:
- O95841
- Q5T5Z5
Protein attributes for ANGPTL1 Gene
- Size:
- 491 amino acids
- Molecular mass:
- 56720 Da
- Quaternary structure:
- No Data Available
Protein Expression for ANGPTL1 Gene
Post-translational modifications for ANGPTL1 Gene
Other Protein References for ANGPTL1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for ANGPTL1 (Angiopoietin-like Protein 1/ANGPTL1)
- Novus Biologicals Antibodies for ANGPTL1
- Abcam antibodies for ANGPTL1 (O95841)
-
Cloud-Clone Corp. Antibodies for ANGPTL1
- Invitrogen Antibodies for ANGPTL1
- antibodies-online Antibodies for ANGPTL1: See all 56
- GeneTex ANGPTL1 antibody for ANGPTL1
-
Santa Cruz Biotechnology (SCBT) Antibodies for ANGPTL1
Protein Products
- Enzo Life Sciences proteins for ANGPTL1
-
OriGene Purified Proteins for ANGPTL1
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- Sino Biological Recombinant Proteins for ANGPTL1
-
Cloud-Clone Corp. Proteins for ANGPTL1
- antibodies-online Proteins for ANGPTL1: See all 12
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- Search GeneTex for Proteins for ANGPTL1
Assay Products
-
Cloud-Clone Corp Assay Kits for ANGPTL1
- antibodies-online Kits for ANGPTL1: See all 40
No data available for DME Specific Peptides for ANGPTL1 Gene
Domains & Families for ANGPTL1 Gene
Gene Families for ANGPTL1 Gene
Protein Domains for ANGPTL1 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for ANGPTL1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
O95841- Domain:
-
- Contains 1 fibrinogen C-terminal domain.
Function for ANGPTL1 Gene
Phenotypes for ANGPTL1 Gene
- MGI mutant phenotypes for ANGPTL1:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for ANGPTL1:
Animal Models for ANGPTL1 Gene
- MGI Knock Outs for ANGPTL1:
-
- Angptl1 tm1Hung
Animal Model Products
-
Taconic Biosciences Mouse Models for ANGPTL1
-
ViGene Biosciences lentiviral particle packaged cDNA for ANGPTL1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for ANGPTL1 gene
- Search ViGene Biosciences for ANGPTL1
CRISPR Products
-
OriGene CRISPR knockouts for ANGPTL1
-
Santa Cruz Biotechnology (SCBT) CRISPR for ANGPTL1
- GenScript: Design CRISPR guide RNA sequences for ANGPTL1
miRNA for ANGPTL1 Gene
- miRTarBase miRNAs that target ANGPTL1
miRNA Products
- Search ViGene Biosciences for ANGPTL1
Clone Products
- OriGene clones in human for ANGPTL1
- OriGene ORF clones in human,mouse,rat for ANGPTL1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for ANGPTL1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for ANGPTL1 gene
-
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Flow Cytometry Products
No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ANGPTL1 Gene
Localization for ANGPTL1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ANGPTL1 Gene
- Secreted.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| mitochondrion | 2 |
| cytosol | 1 |
| endoplasmic reticulum | 1 |
| peroxisome | 1 |
| plasma membrane | 1 |
No data available for Gene Ontology (GO) - Cellular Components for ANGPTL1 Gene
Pathways & Interactions for ANGPTL1 Gene
More details on SuperPathways for ANGPTL1| Superpath | Contained pathways | ||
|---|---|---|---|
| 1 | PEDF Induced Signaling |
.61
|
.47
|
| 2 | TGF-Beta Pathway |
.60
.57
|
.51
.40
|
| 3 | Akt Signaling |
.60
.60
|
|
| 4 | ERK Signaling |
.61
|
|
| 5 | Immune response IL-23 signaling pathway |
Pathways by source for ANGPTL1 Gene
1 GeneGo (Thomson Reuters) pathway for ANGPTL1 Gene
26 Qiagen pathways for ANGPTL1 Gene
Transcripts for ANGPTL1 Gene
mRNA/cDNA for ANGPTL1 Gene
- (2) REFSEQ mRNAs :
- (8) Additional mRNA sequences :
- (89) Selected AceView cDNA sequences:
- (3) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for ANGPTL1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for ANGPTL1
-
Santa Cruz Biotechnology (SCBT) CRISPR for ANGPTL1
- GenScript: Design CRISPR guide RNA sequences for ANGPTL1
miRNA Products
- Search ViGene Biosciences for ANGPTL1
Clone Products
- OriGene clones in human for ANGPTL1
- OriGene ORF clones in human,mouse,rat for ANGPTL1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for ANGPTL1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Flow Cytometry Products
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||||||||||
| SP2: | |||||||||||||||||||||
| SP3: | |||||||||||||||||||||
| SP4: | - | - |
Expression for ANGPTL1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Bone (Muscoskeletal System)
- Limb (Muscoskeletal System)
-
Yolk Sac (Extraembryonic Tissues)
- Definitive Hematopoietic Stem Cells Definitive Yolk Sac
-
Blood (Cardiovascular System)
- Definitive Hematopoietic Stem Cells Definitive Yolk Sac
- Gut Tube (Gastrointestinal Tract)
-
Placenta (Extraembryonic Tissues)
-
Dermis (Integumentary System)
-
Ovary (Reproductive System)
mRNA differential expression in normal tissues according to GTEx for ANGPTL1 Gene
This gene is overexpressed in Artery - Tibial (x4.1).
This gene is overexpressed in Vitreous humor (51.6) and Ovary (11.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ANGPTL1 Gene
SOURCE GeneReport for Unigene cluster for ANGPTL1 Gene Hs.591474
mRNA Expression by UniProt/SwissProt for ANGPTL1 Gene
O95841-ANGL1_HUMAN
Tissue specificity:
Highly expressed in adrenal gland, placenta, thyroid gland, heart, skeletal muscle and small intestine. Weakly expressed in testis, ovary, colon, pancreas, kidney and stomach.
Primer Products
-
OriGene qPCR primer pairs for ANGPTL1
-
OriGene qPCR primer pairs and template standards for ANGPTL1
No data available for Protein tissue co-expression partners for ANGPTL1 Gene
Orthologs for ANGPTL1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| cow (Bos Taurus) |
Mammalia | ANGPTL1 35 |
|
||
| ANGPTL1 36 |
|
OneToOne | |||
| dog (Canis familiaris) |
Mammalia | ANGPTL1 35 |
|
||
| ANGPTL1 36 |
|
OneToOne | |||
| mouse (Mus musculus) |
Mammalia | Angptl1 35 |
|
||
| Angptl1 16 |
|
||||
| Angptl1 36 |
|
OneToOne | |||
| chimpanzee (Pan troglodytes) |
Mammalia | ANGPTL1 35 |
|
||
| ANGPTL1 36 |
|
OneToOne | |||
| oppossum (Monodelphis domestica) |
Mammalia | ANGPTL1 36 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | ANGPTL1 36 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | ANGPTL1 35 |
|
||
| ANGPTL1 36 |
|
OneToOne | |||
| lizard (Anolis carolinensis) |
Reptilia | ANGPTL1 36 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | angptl1 35 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | angptl1 35 |
|
||
| angptl1 36 |
|
OneToMany | |||
| ANGPTL1 (1 of 2) 36 |
|
OneToMany | |||
| fruit fly (Drosophila melanogaster) |
Insecta | BG:DS00929.7 37 |
|
|
|
| CG10359 37 |
|
|
|||
| CG1791 37 |
|
|
|||
| CG1889 37 |
|
|
|||
| CG30280 37 |
|
|
|||
| CG30281 37 |
|
|
|||
| CG5550 37 |
|
|
|||
| CG8642 37 |
|
|
|||
| CG9500 37 |
|
|
|||
| sca 37 |
|
|
|||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 36 |
|
OneToMany |
- Species with no ortholog for ANGPTL1:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for ANGPTL1 Gene
Paralogs for ANGPTL1 Gene
(9) SIMAP similar genes for ANGPTL1 Gene using alignment to 1 proteins:
Variants for ANGPTL1 Gene
Residual Variation Intolerance Score:
42% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.77;
33.53% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for ANGPTL1 Gene
- HapMap Linkage Disequilibrium report
- ANGPTL1
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for ANGPTL1 Gene
Disorders for ANGPTL1 Gene
Relevant External Links for ANGPTL1
No disorders were found for ANGPTL1 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANGPTL1 Gene
Publications for ANGPTL1 Gene
- Molecular cloning and characterization of a novel angiopoietin family protein, angiopoietin-3. (PMID: 10025962) Kim I. … Koh G.Y. (FEBS Lett. 1999) 2 3 4 23 67
- Recombinant angioarrestin secreted from mouse melanoma cells inhibits growth of primary tumours. (PMID: 15940350) Smagur A. … Szala S. (Acta Biochim. Pol. 2005) 3 23
- Angioarrestin: a unique angiopoietin-related protein with anti-angiogenic properties. (PMID: 15950186) Dhanabal M. … Lichenstein H.S. (Biochem. Biophys. Res. Commun. 2005) 3 23
- Construction of a 1.2-Mb sequence-ready contig of chromosome 11q13 encompassing the multiple endocrine neoplasia type 1 (MEN1) gene. The European Consortium on MEN1. (PMID: 9286704) Lemmens I. … Thakker R.V. (Genomics 1997) 2 3
- Retinoic acid receptor beta and angiopoietin-like protein 1 are involved in the regulation of human androgen biosynthesis. (PMID: 25970467) Udhane S.S. … FlA1ck C.E. (Sci Rep 2015) 3
Products for ANGPTL1 Gene
- R&D Systems Antibodies for ANGPTL1 (Angiopoietin-like Protein 1/ANGPTL1)
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- Custom Antibody ServicesOriGene Antibodies for ANGPTL1
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- OriGene qPCR primer pairs for ANGPTL1
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- Cloud-Clone Corp. Antibodies for ANGPTL1
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- Taconic Biosciences Mouse Models for ANGPTL1
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- Humanized Mice
- antibodies-online Antibodies for ANGPTL1: See all 56
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- antibodies-online Proteins for ANGPTL1: See all 12
- Search antibodies-online for peptides
- GeneTex ANGPTL1 antibody for ANGPTL1
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- ViGene Biosciences adenoviral particle packaged cDNA for ANGPTL1 gene
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- ViGene Biosciences ready-to-package AAV shRNAs for ANGPTL1 gene
- ViGene Biosciences ready-to-package AAV shRNAs for ANGPTL1 gene
- ViGene Biosciences ready-to-package AAV shRNAs for ANGPTL1 gene
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- Santa Cruz Biotechnology (SCBT) Antibodies for ANGPTL1
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Sources for ANGPTL1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
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- (20) STRING
- (21) I2D
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) UniGene
- (28) AceView
- (29) RNAdb
- (30) ASD
- (31) ECgene
- (32) GeneAnnot
- (33) SAGE
- (34) SOURCE
- (35) HomoloGene
- (36) PanEnsembl
- (37) euGenes
- (38) SGD
- (39) FlyBase
- (40) WormBase
- (41) Pseudogene
- (42) DGV
- (43) dbSNP
- (44) HapMap
- (45) GenAtlas
- (46) GeneTests
- (47) HGMD
- (48) GAD
- (49) LSDB
- (50) BGMUT
- (51) HuGE
- (52) eBioscience
- (53) Atlas
- (54) Cell Signaling Technology
- (55) GenBank
- (56) H-invDB
- (57) HORDE
- (58) HUGE
- (59) IMGT
- (60) Leiden
- (61) MILLIPORE
- (62) miRBase
- (63) DME
- (64) Nature
- (65) NCBI
- (66) OriGene
- (67) PubMed
- (68) R&D Systems
- (69) Salk
- (70) TGDB
- (71) Tufts
- (72) YEDA
- (73) CROW21
- (74) Tocris
- (75) Abcam
- (76) Novus
- (77) ProSpec
- (78) Sino Biological
- (79) GenScript
- (80) Qiagen
- (81) Cloud-Clone Corp.
- (82) Enzo Life Sciences
- (83) OCA
- (84) Proteopedia
- (85) MOPED
- (86) SPIRE
- (87) neXtProt
- (88) Reactome
- (89) GeneGo (Thomson Reuters)
- (90) fRNAdb
- (91) DISEASES
- (92) SIMAP
- (93) GenomeRNAi
- (94) LifeMap
- (95) miRTarBase
- (96) MalaCards
- (97) Invitrogen
- (98) BitterDB
- (99) Vector BioLabs
- (100) ESI-BIO
- (101) RefSeq
- (102) BioSystems
- (103) MaxQB
- (104) IUPHAR
- (105) BioGPS
- (106) Illumina
- (107) COMPARTMENTS
- (108) HOMER
- (109) PaxDb
- (110) ApexBio
- (111) Addgene
- (112) Advanced Cell Diagnostics
- (113) antibodies-online
- (114) CYP
- (115) NONCODE
- (116) SwitchGear Genomics
- (117) TreeFam
- (118) PathCards
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- (148) FANTOM5
- (149) ENCODE
- (150) ProSci
- (151) Horizon