Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



ANGPTL1 Gene

protein-coding   GIFtS: 59
GCID: GC01M178818

Angiopoietin-Like 1


(Previous symbol: ANGPT3)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Angiopoietin-Like 11 2     UNQ1622
ANGPT31 2 3     Angiopoietin 32
angioarrestin1 2     Angiopoietin Y12
Angiopoietin-Like Protein 12 3     angiopoietin-32
ANG-32 3     Angiopoietin-Related Protein 12
ANG32 3     dJ595C2.22
ARP12 3     DJ595C2.2 (Angiopoietin Y1)2
AngY2     Angiopoietin-33

External Ids:    HGNC: 4891   Entrez Gene: 90682   Ensembl: ENSG000001161947   OMIM: 6038745   UniProtKB: O958413   

Export aliases for ANGPTL1 gene to outside databases

Previous GC identifers: GC01M176344 GC01M174248 GC01M175400 GC01M176059 GC01M176060 GC01M175551 GC01M177085 GC01M150047


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for ANGPTL1 Gene:
Angiopoietins are members of the vascular endothelial growth factor family and the only known growth factors
largely specific for vascular endothelium. Angiopoietin-1, angiopoietin-2, and angiopoietin-4 participate in the
formation of blood vessels. The protein encoded by this gene is another member of the angiopoietin family that is
widely expressed in adult tissues with mRNA levels highest in highly vascularized tissues. This protein was found
to be a secretory protein that does not act as an endothelial cell mitogen in vitro. (provided by RefSeq, Jul
2008)

GeneCards Summary for ANGPTL1 Gene:
ANGPTL1 (angiopoietin-like 1) is a protein-coding gene. Diseases associated with ANGPTL1 include multiple endocrine neoplasia, and endotheliitis. GO annotations related to this gene include receptor binding. An important paralog of this gene is FGL2.

Gene Wiki entry for ANGPTL1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000001.11  NT_004487.20  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ANGPTL1 gene promoter:
         HFH-3   GR   HNF-3beta   FOXL1   MEF-2A   FOXI1   Nkx6-1   STAT3   aMEF-2   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidANGPTL1 promoter sequence
   Search Chromatin IP Primers for ANGPTL1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ANGPTL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q25.2   Ensembl cytogenetic band:  1q25.2   HGNC cytogenetic band: 1q25.2

ANGPTL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ANGPTL1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M178818:  view genomic region     (about GC identifiers)

Start:
178,818,670 bp from pter      End:
178,840,215 bp from pter
Size:
21,546 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: ANGL1_HUMAN, O95841 (See protein sequence)
Recommended Name: Angiopoietin-related protein 1 precursor  
Size: 491 amino acids; 56720 Da
Secondary accessions: Q5T5Z5

Explore the universe of human proteins at neXtProt for ANGPTL1: NX_O95841

Explore proteomics data for ANGPTL1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn160, Asn188

  • See ANGPTL1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004664.1  
    ENSEMBL proteins: 
     ENSP00000234816   ENSP00000356601   ENSP00000392023  

    ANGPTL1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Enzo Life Sciences proteins for ANGPTL1
    OriGene Purified Protein for ANGPTL1
    OriGene Protein Over-expression Lysate for ANGPTL1
    OriGene Custom MassSpec
    OriGene Custom Protein Services for ANGPTL1
    GenScript Custom Purified and Recombinant Proteins Services for ANGPTL1
    Novus Biologicals ANGPTL1 Protein
    Novus Biologicals ANGPTL1 Lysate
    Sino Biological Recombinant Protein for ANGPTL1
    Sino Biological Cell Lysate for ANGPTL1
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ANGPTL1

    ANGPTL1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for ANGPTL1 (Angiopoietin-like Protein 1/ANGPTL1)
    OriGene Antibodies for ANGPTL1
    OriGene Custom Antibody Services for ANGPTL1
    Novus Biologicals ANGPTL1 Antibodies
    Abcam antibodies for ANGPTL1
    Cloud-Clone Corp. Antibodies for ANGPTL1
    ThermoFisher Antibody for ANGPTL1
    LSBio Antibodies in human, mouse, rat for ANGPTL1

    ANGPTL1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ANGPTL1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ANGPTL1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ANGPTL1
    Cloud-Clone Corp. CLIAs for ANGPTL1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    FIBC: Fibrinogen C domain containing

    4 InterPro protein domains:
     IPR014715 Fibrinogen_a/b/g_C_2
     IPR014716 Fibrinogen_a/b/g_C_1
     IPR020837 Fibrinogen_CS
     IPR002181 Fibrinogen_a/b/g_C_dom

    Graphical View of Domain Structure for InterPro Entry O95841

    ProtoNet protein and cluster: O95841

    1 Blocks protein domain: IPB002181 Fibrinogen

    UniProtKB/Swiss-Prot: ANGL1_HUMAN, O95841
    Similarity: Contains 1 fibrinogen C-terminal domain


    ANGPTL1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding IEA--
         
    ANGPTL1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for ANGPTL1:
     G0/1 arrest  Increased G1 DNA content 

         1 MGI mutant phenotype (inferred from 2 alleles(MGI details for Angptl1):
     normal 

    ANGPTL1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Angptl1tm1Lex for ANGPTL1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ANGPTL1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ANGPTL1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ANGPTL1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ANGPTL1

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat ANGPTL1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ANGPTL1 (see all 22):
    hsa-miR-411* hsa-miR-320a hsa-miR-379* hsa-miR-4272 hsa-miR-340 hsa-miR-570 hsa-miR-1323 hsa-miR-186
    SwitchGear 3'UTR luciferase reporter plasmidANGPTL1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ANGPTL1
    Predesigned siRNA for gene silencing in human, mouse, rat ANGPTL1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ANGPTL1

    Clone
    Products:
         
    OriGene clones in human, mouse for ANGPTL1 (see all 7)
    OriGene ORF clones in mouse, rat for ANGPTL1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ANGPTL1 (NM_004673)
    Sino Biological Human cDNA Clone for ANGPTL1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ANGPTL1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ANGPTL1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ANGPTL1
    Browse ESI BIO Cell Lines and PureStem Progenitors for ANGPTL1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANGPTL1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    ANGL1_HUMAN, O95841: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    mitochondrion2
    cytosol1
    endoplasmic reticulum1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IDA10025962
    GO:0070062extracellular vesicular exosome IDA19199708

    ANGPTL1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for ANGPTL1 About   (see all 6)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Immune response IL 23 signaling pathway
    Development Angiopoietin Tie2 signaling0.38
    Angiopoietin-TIE2 Signaling0.36
    2PEDF Induced Signaling
    MIF Regulation of Innate Immune Cells0.94
    NFAT Signaling and Lymphocyte Interactions0.57
    MIF Mediated Glucocorticoid Regulation0.94
    PGC1Alpha Pathway0.51
    PEDF Induced Signaling0.73
    STAT3 Pathway0.47
    all-trans-Retinoic Acid Signaling in Brain0.71
    Endothelin-1 Signaling Pathway0.46
    3TGF-Beta Pathway
    TGF-Beta Pathway0.60
    JNK Pathway0.51
    MAPK Family Pathway0.60
    Regulation of eIF4 and p70S6K0.43
    JAK-STAT Pathway0.57
    SOCS Pathway0.40
    4Akt Signaling
    Akt Signaling0.60
    Tec Kinases Signaling0.55
    p38 Signaling0.60
    5ERK Signaling
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for ANGPTL1 (see all 26)
        Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    NFAT Signaling and Lymphocyte Interactions
    JNK Pathway

    1 GeneGo (Thomson Reuters) Pathway for ANGPTL1
        Development Angiopoietin - Tie2 signaling



        Pathway & Disease-focused RT2 Profiler PCR Array including ANGPTL1: 
              Angiogenic Growth Factors in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for ANGPTL1

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    5 Interacting proteins for ANGPTL1 (O958413 ENSP000002348164) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TEKQ027633, ENSP000003839774I2D: score=2 STRING: ENSP00000383977
    NR2F6P105883, ENSP000002914424I2D: score=1 STRING: ENSP00000291442
    PDPK1O155303I2D: score=1 
    PRKAA1Q131313I2D: score=1 
    TIE1ENSP000003615544STRING: ENSP00000361554
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007169transmembrane receptor protein tyrosine kinase signaling pathway IEA--

    ANGPTL1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ANGPTL1 (ANGL1)

    1 Novoseek inferred chemical compound relationship for ANGPTL1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 21.7 1 15342395 (1)



    ANGPTL1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for ANGPTL1 gene: 
    NM_004673.3  

    Unigene Cluster for ANGPTL1:

    Angiopoietin-like 1
    Hs.591474  [show with all ESTs]
    Unigene Representative Sequence: NM_004673
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000234816(uc010pnc.1 uc001gma.3 uc001gmb.3) ENST00000367629
    ENST00000444255
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ANGPTL1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ANGPTL1 (see all 22):
    hsa-miR-411* hsa-miR-320a hsa-miR-379* hsa-miR-4272 hsa-miR-340 hsa-miR-570 hsa-miR-1323 hsa-miR-186
    SwitchGear 3'UTR luciferase reporter plasmidANGPTL1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ANGPTL1
    Predesigned siRNA for gene silencing in human, mouse, rat ANGPTL1
    Clone
    Products:
         
    OriGene clones in human, mouse for ANGPTL1 (see all 7)
    OriGene ORF clones in mouse, rat for ANGPTL1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ANGPTL1 (NM_004673)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ANGPTL1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ANGPTL1
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for ANGPTL1
    OriGene qSTAR qPCR primer pairs in human, mouse for ANGPTL1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ANGPTL1
      QuantiTect SYBR Green Assays in human, mouse, rat ANGPTL1
      QuantiFast Probe-based Assays in human, mouse, rat ANGPTL1

    Additional mRNA sequence: 

    AB056476.1 AF086266.1 AF107253.1 AK223467.1 AK300218.1 AY358278.1 BC047670.1 BC050640.1 

    4 DOTS entries:

    DT.100758324  DT.121429248  DT.121429253  DT.86844047 

    Selected AceView cDNA sequences (see all 89):

    BU753998 BI523583 BC050640 CR621065 CD722776 AF107253 BX378529 AI001937 
    AI376255 NM_004673 BC047670 AI927629 BP372640 AI381675 AB056476 AF086266 
    AA131275 AA463383 BQ130597 BP343441 BX500730 BX499002 BM671294 BP379215 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for ANGPTL1    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8
    SP1:                                                                  
    SP2:                                                                  
    SP3:                                                                  
    SP4:        -     -                                                   


    ECgene alternative splicing isoforms for ANGPTL1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    ANGPTL1 expression in normal human tissues (normalized intensities)      ANGPTL1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTCAAGATAC
    ANGPTL1 Expression
    About this image


    ANGPTL1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 3 entries
             Zeugopod Growth Plate
     
     Limb (Muscoskeletal System)    fully expand to see all 3 entries
             Zeugopod
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Yolk Sac (Extraembryonic Tissues)
             Definitive Hematopoietic Stem Cells Definitive Yolk Sac
     
     Blood (Cardiovascular System)
             Definitive Hematopoietic Stem Cells Definitive Yolk Sac
    ANGPTL1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ANGPTL1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.591474

    UniProtKB/Swiss-Prot: ANGL1_HUMAN, O95841
    Tissue specificity: Highly expressed in adrenal gland, placenta, thyroid gland, heart, skeletal muscle and small
    intestine. Weakly expressed in testis, ovary, colon, pancreas, kidney and stomach

        Pathway & Disease-focused RT2 Profiler PCR Array including ANGPTL1: 
              Angiogenic Growth Factors in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for ANGPTL1
    OriGene qSTAR qPCR primer pairs in human, mouse for ANGPTL1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ANGPTL1
    QuantiTect SYBR Green Assays in human, mouse, rat ANGPTL1
    QuantiFast Probe-based Assays in human, mouse, rat ANGPTL1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANGPTL1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for ANGPTL1 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Angptl11 , 5 angiopoietin-like 11, 5 88.71(n)1
    93.06(a)1
      1 (67.75 cM)5
    727131  NM_028333.21  NP_082609.21 
     1568385625 
    chicken
    (Gallus gallus)
    Aves ANGPTL11 angiopoietin-like 1 79.21(n)
    84.87(a)
      770850  NM_001277665.1  NP_001264594.1 
    lizard
    (Anolis carolinensis)
    Reptilia ANGPTL16
    angiopoietin-like 1
    81(a)
    1 ↔ 1
    GL343300.1(643467-658447)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia angptl11 angiopoietin-like 1 71.75(n)
    76.7(a)
      100170184  NM_001129936.1  NP_001123408.1 
    zebrafish
    (Danio rerio)
    Actinopterygii angptl11 angiopoietin-like 1 63.37(n)
    65.89(a)
      544656  NM_001014820.1  NP_001014820.1 


    ENSEMBL Gene Tree for ANGPTL1 (if available)
    TreeFam Gene Tree for ANGPTL1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for ANGPTL1 gene
    FGL22  ANGPT42  FGG2  FIBCD12  ANGPTL62  FCN32  ANGPTL22  FCN22  
    FCN12  ANGPT12  ANGPTL72  FGB2  ANGPT22  MFAP42  FGL12  
    9 SIMAP similar genes for ANGPTL1 using alignment to 1 protein entry:     ANGL1_HUMAN:
    ANGPTL2    ANGPTL7    FGL1    LFIRE1    ANGPT1    ANGPTL6
    FCN3    FIBCD1    ANGPT4

    ANGPTL1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus
    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for ANGPTL1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv3710CNV Insertion18451855
    nsv872572CNV Loss21882294
    nsv525444CNV Loss19592680
    nsv470748CNV Gain18288195
    nsv466206CNV Gain19166990

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing ANGPTL1
    DNA2.0 Custom Variant and Variant Library Synthesis for ANGPTL1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 603874    OMIM disorders: --

    5 diseases for ANGPTL1:    About MalaCards
    multiple endocrine neoplasia    endotheliitis    melanoma    lung cancer
    thyroiditis


    ANGPTL1 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for ANGPTL1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    melanoma 19.5 3 15940350 (3)
    tumors 0 10 15342395 (3), 15950186 (1)

    Genetic Association Database (GAD): ANGPTL1
    Human Genome Epidemiology (HuGE) Navigator: ANGPTL1 (1 document)

    Export disorders for ANGPTL1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for ANGPTL1 gene, integrated from 10 sources (see all 30):
    (articles sorted by number of sources associating them with ANGPTL1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and characterization of a novel angiopoietin family protein, angiopoietin-3. (PubMed id 10025962)1, 2, 3, 9 Kim I.... Koh G.Y. (FEBS Lett. 1999)
    2. MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer. (PubMed id 20819778)1, 4 Zhang X....Wu X. (Carcinogenesis 2010)
    3. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    4. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1, 2 Otsuki T....Isogai T. (DNA Res. 2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Construction of a 1.2-Mb sequence-ready contig of chromosome 11q13 encompassing the multiple endocrine neoplasia type 1 (MEN1) gene. The European Consortium on MEN1. (PubMed id 9286704)1, 3 Lemmens I....Thakker R.V. (Genomics 1997)
    7. Recombinant angioarrestin secreted from mouse melanoma cells inhibits growth of primary tumours. (PubMed id 15940350)1, 9 Smagur A....Szala S. (Acta Biochim. Pol. 2005)
    8. Angioarrestin: a unique angiopoietin-related protein with anti-angiogenic properties. (PubMed id 15950186)1, 9 Dhanabal M....Lichenstein H.S. (Biochem. Biophys. Res. Commun. 2005)
    9. Angiopoietin-like protein 1 suppresses SLUG to inhibit cancer cell motility. (PubMed id 23434592)1 Kuo T.C....Kuo M.L. (J. Clin. Invest. 2013)
    10. Metalloproteinases, vascular endothelial growth factor, and angiopoietin 1 and 2 in eutopic and ectopic endometrium. (PubMed id 18644593)1 Di Carlo C....Nappi C. (Fertil. Steril. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 9068 HGNC: 489 AceView: ANGPTL1 Ensembl:ENSG00000116194 euGenes: HUgn9068
    ECgene: ANGPTL1 H-InvDB: ANGPTL1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for ANGPTL1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ANGPTL1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for ANGPTL1 gene:
    Search GeneIP for patents involving ANGPTL1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Antibodies for ANGPTL1 (Angiopoietin-like Protein 1/ANGPTL1)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for ANGPTL1   OriGene RNAi products in human, mouse, rat for ANGPTL1  
     OriGene qPCR primer pairs and template standards for ANGPTL1   OriGene Protein Over-expression Lysate for ANGPTL1  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for ANGPTL1  
     OriGene qSTAR qPCR primer pairs in human, mouse for ANGPTL1   OriGene Purified Protein for ANGPTL1  
     OriGene ORF clones in mouse, rat for ANGPTL1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ANGPTL1   OriGene Custom Protein Services for ANGPTL1  

     
     
     Block miRNA regulation of human, mouse, rat ANGPTL1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing ANGPTL1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ANGPTL1 Predesigned siRNA for gene silencing in human, mouse, rat ANGPTL1
     QuantiFast Probe-based Assays in human, mouse, rat ANGPTL1 QuantiTect SYBR Green Assays in human, mouse, rat ANGPTL1
     PCR Arrays including human, mouse, rat ANGPTL1 Search Chromatin IP Primers for ANGPTL1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ANGPTL1  Search GeneGlobe Interaction Network for ANGPTL1
     Regulatory tfbs in ANGPTL1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for ANGPTL1 GenScript cDNA clones with any tag delivered in your preferred vector for ANGPTL1
     GenScript Custom Assay Services for ANGPTL1 GenScript Custom overexpressing Cell Line Services for ANGPTL1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for ANGPTL1 (ANGL1)
     Proteins for ANGPTL1
     Cell Lysates for ANGPTL1
     cDNA Clones for ANGPTL1
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Proteins for ANGPTL1
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     ANGPTL1 antibodies
     ANGPTL1 proteins
     ANGPTL1 lysates
     Antibodies for ANGPTL1
     See all of Abcam's Antibodies, Kits and Proteins for ANGPTL1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for ANGPTL1
     Antibodies for ANGPTL1
     ELISAs for ANGPTL1
     CLIAs for ANGPTL1



     Browse ESI BIO Cell Lines and PureStem Progenitors for ANGPTL1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANGPTL1
     SwitchGear 3'UTR luciferase reporter plasmids for ANGPTL1
     SwitchGear Promoter luciferase reporter plasmids for ANGPTL1
     ThermoFisher Antibody for ANGPTL1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ANGPTL1
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ANGPTL1
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ANGPTL1
     LSBio Antibodies in human, mouse, rat for ANGPTL1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      ANGPTL1 gene at Home site.
    Version: 3.12.136 22 July 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4