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Aliases for ANGPT4 Gene

Aliases for ANGPT4 Gene

  • Angiopoietin 4 2 3 5
  • ANG3 3 4
  • ANG4 3 4
  • Angiopoietin-3 4
  • ANG-3 4
  • ANG-4 4

External Ids for ANGPT4 Gene

Previous GeneCards Identifiers for ANGPT4 Gene

  • GC20M000841
  • GC20M000848
  • GC20M000801
  • GC20M000805
  • GC20M000853

Summaries for ANGPT4 Gene

Entrez Gene Summary for ANGPT4 Gene

  • Angiopoietins are proteins with important roles in vascular development and angiogenesis. All angiopoietins bind with similar affinity to an endothelial cell-specific tyrosine-protein kinase receptor. The mechanism by which they contribute to angiogenesis is thought to involve regulation of endothelial cell interactions with supporting perivascular cells. The protein encoded by this gene functions as an agonist and is an angiopoietin. [provided by RefSeq, Jul 2008]

GeneCards Summary for ANGPT4 Gene

ANGPT4 (Angiopoietin 4) is a Protein Coding gene. Among its related pathways are ERK Signaling and TGF-Beta Pathway. GO annotations related to this gene include receptor tyrosine kinase binding and transmembrane receptor protein tyrosine kinase activator activity. An important paralog of this gene is FGB.

UniProtKB/Swiss-Prot for ANGPT4 Gene

  • Binds to TEK/TIE2, modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2. Promotes endothelial cell survival, migration and angiogenesis.

Gene Wiki entry for ANGPT4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANGPT4 Gene

Genomics for ANGPT4 Gene

Regulatory Elements for ANGPT4 Gene

Enhancers for ANGPT4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ANGPT4 on UCSC Golden Path with GeneCards custom track

Genomic Location for ANGPT4 Gene

869,899 bp from pter
916,375 bp from pter
46,477 bases
Minus strand

Genomic View for ANGPT4 Gene

Genes around ANGPT4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANGPT4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANGPT4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANGPT4 Gene

Proteins for ANGPT4 Gene

  • Protein details for ANGPT4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • B4E3J9
    • Q5TFF4
    • Q9H4Z4

    Protein attributes for ANGPT4 Gene

    503 amino acids
    Molecular mass:
    56849 Da
    Quaternary structure:
    • Homodimer; disulfide-linked. Interacts with TEK/TIE2.

    Alternative splice isoforms for ANGPT4 Gene


neXtProt entry for ANGPT4 Gene

Proteomics data for ANGPT4 Gene at MOPED

Post-translational modifications for ANGPT4 Gene

  • Glycosylation at Asn 96, Asn 126, Asn 140, Asn 158, Asn 247, Asn 274, Asn 311, Asn 337, and Asn 427
  • Modification sites at PhosphoSitePlus

Other Protein References for ANGPT4 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for ANGPT4 (Angiopoietin-4)

No data available for DME Specific Peptides for ANGPT4 Gene

Domains & Families for ANGPT4 Gene

Gene Families for ANGPT4 Gene

Suggested Antigen Peptide Sequences for ANGPT4 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 fibrinogen C-terminal domain.
  • Contains 1 fibrinogen C-terminal domain.
genes like me logo Genes that share domains with ANGPT4: view

Function for ANGPT4 Gene

Molecular function for ANGPT4 Gene

GENATLAS Biochemistry:
angiopoietin 4 secreted ligand for the vascular endothelial restricted receptor tyrosine kinase TEK,including phosphorylation of TEK,promoting angiogenic remodeling as well as vessel maturation and stabilization,predominantly expressed in lung
UniProtKB/Swiss-Prot Function:
Binds to TEK/TIE2, modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2. Promotes endothelial cell survival, migration and angiogenesis.

Gene Ontology (GO) - Molecular Function for ANGPT4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030971 receptor tyrosine kinase binding IDA 10051567
genes like me logo Genes that share ontologies with ANGPT4: view
genes like me logo Genes that share phenotypes with ANGPT4: view

Animal Model Products

CRISPR Products

miRNA for ANGPT4 Gene

miRTarBase miRNAs that target ANGPT4

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ANGPT4 Gene

Localization for ANGPT4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ANGPT4 Gene


Subcellular locations from

Jensen Localization Image for ANGPT4 Gene COMPARTMENTS Subcellular localization image for ANGPT4 gene
Compartment Confidence
extracellular 5
nucleus 2
endoplasmic reticulum 1

No data available for Gene Ontology (GO) - Cellular Components for ANGPT4 Gene

Pathways & Interactions for ANGPT4 Gene

genes like me logo Genes that share pathways with ANGPT4: view

SIGNOR curated interactions for ANGPT4 Gene


Gene Ontology (GO) - Biological Process for ANGPT4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IEA --
GO:0001935 NOT endothelial cell proliferation IDA 10025962
GO:0007171 activation of transmembrane receptor protein tyrosine kinase activity IDA 10051567
GO:0007219 Notch signaling pathway IEA --
GO:0007596 blood coagulation TAS --
genes like me logo Genes that share ontologies with ANGPT4: view

Drugs & Compounds for ANGPT4 Gene

(1) Drugs for ANGPT4 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for ANGPT4 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ANGPT4: view

Transcripts for ANGPT4 Gene

mRNA/cDNA for ANGPT4 Gene

(9) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ANGPT4 Gene

Angiopoietin 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ANGPT4 Gene

No ASD Table

Relevant External Links for ANGPT4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ANGPT4 Gene

mRNA expression in normal human tissues for ANGPT4 Gene

mRNA differential expression in normal tissues according to GTEx for ANGPT4 Gene

This gene is overexpressed in Adipose - Subcutaneous (x5.8), Adipose - Visceral (Omentum) (x5.1), Breast - Mammary Tissue (x4.3), and Cervix - Endocervix (x4.1).

Protein differential expression in normal tissues from HIPED for ANGPT4 Gene

This gene is overexpressed in Placenta (59.6) and Platelet (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ANGPT4 Gene

SOURCE GeneReport for Unigene cluster for ANGPT4 Gene Hs.278973

mRNA Expression by UniProt/SwissProt for ANGPT4 Gene

Tissue specificity: Highly expressed in the lung with much lower levels found in other tissues.
genes like me logo Genes that share expression patterns with ANGPT4: view

Protein tissue co-expression partners for ANGPT4 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for ANGPT4 Gene

Orthologs for ANGPT4 Gene

This gene was present in the common ancestor of animals.

Orthologs for ANGPT4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ANGPT4 35
  • 80.99 (n)
  • 68.88 (a)
  • 68 (a)
(Canis familiaris)
Mammalia ANGPT4 35
  • 81.12 (n)
  • 69.88 (a)
  • 69 (a)
(Mus musculus)
Mammalia Angpt4 35
  • 70.82 (n)
  • 56.14 (a)
Angpt4 16
Angpt4 36
  • 54 (a)
(Pan troglodytes)
Mammalia ANGPT4 35
  • 97.36 (n)
  • 96.15 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Angpt4 35
  • 71.7 (n)
  • 56.54 (a)
(Monodelphis domestica)
Mammalia ANGPT4 36
  • 59 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 24 (a)
(Gallus gallus)
Aves ANGPT4 35
  • 68.53 (n)
  • 55.28 (a)
  • 52 (a)
(Anolis carolinensis)
Reptilia ANGPT4 36
  • 55 (a)
(Danio rerio)
Actinopterygii angpt4 36
  • 44 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10359 37
  • 38 (a)
CG9500 37
  • 38 (a)
sca 37
  • 27 (a)
Species with no ortholog for ANGPT4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ANGPT4 Gene

Gene Tree for ANGPT4 (if available)
Gene Tree for ANGPT4 (if available)

Paralogs for ANGPT4 Gene

Paralogs for ANGPT4 Gene

(12) SIMAP similar genes for ANGPT4 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ANGPT4: view

Variants for ANGPT4 Gene

Sequence variations from dbSNP and Humsavar for ANGPT4 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs869171 - 878,198(-) AGTAC(A/G)AACAT reference, missense
rs487473 -- 909,226(+) AAGTG(C/T)CTGGC intron-variant, upstream-variant-2KB
rs511431 -- 910,030(+) TCCAG(C/G)TCCCA intron-variant, upstream-variant-2KB
rs511465 -- 910,036(+) TCCCA(A/G)CTAAT intron-variant, upstream-variant-2KB
rs534081 -- 899,447(+) acggg(A/G)tttca intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ANGPT4 Gene

Variant ID Type Subtype PubMed ID
nsv912580 CNV Gain 21882294
nsv510778 CNV Loss 20534489
nsv458848 CNV Loss 19166990
nsv912582 CNV Loss 21882294
nsv912583 CNV Loss 21882294
esv274947 CNV Gain+Loss 21479260
nsv817879 CNV Gain 17921354
nsv912584 CNV Loss 21882294

Variation tolerance for ANGPT4 Gene

Residual Variation Intolerance Score: 52.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.57; 56.00% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ANGPT4 Gene

Disorders for ANGPT4 Gene

Relevant External Links for ANGPT4

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ANGPT4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANGPT4 Gene

Publications for ANGPT4 Gene

  1. Angiopoietins 3 and 4: diverging gene counterparts in mice and humans. (PMID: 10051567) Valenzuela D.M. … Yancopoulos G.D. (Proc. Natl. Acad. Sci. U.S.A. 1999) 2 3 4 23 67
  2. Angiopoietin-4 inhibits angiogenesis and reduces interstitial fluid pressure. (PMID: 16790085) Olsen M.W. … Kristjansen P.E. (Neoplasia 2006) 3 23
  3. Multiple angiopoietin recombinant proteins activate the Tie1 receptor tyrosine kinase and promote its interaction with Tie2. (PMID: 15851516) Saharinen P. … Alitalo K. (J. Cell Biol. 2005) 3 23
  4. Expression of angiopoietins in renal epithelial and clear cell carcinoma cells: regulation by hypoxia and participation in angiogenesis. (PMID: 15198927) Yamakawa M. … Jiang C. (Am. J. Physiol. Renal Physiol. 2004) 3 23
  5. Biological characterization of angiopoietin-3 and angiopoietin-4. (PMID: 15284220) Lee H.J. … Koh G.Y. (FASEB J. 2004) 3 23

Products for ANGPT4 Gene

Sources for ANGPT4 Gene