Aliases for ANGPT4 Gene
Aliases for ANGPT4 Gene
External Ids for ANGPT4 Gene
- HGNC: 487
- Entrez Gene: 51378
- Ensembl: ENSG00000101280
- OMIM: 603705
- UniProtKB: Q9Y264
Previous GeneCards Identifiers for ANGPT4 Gene
- GC20M000841
- GC20M000848
- GC20M000801
- GC20M000805
- GC20M000853
Summaries for ANGPT4 Gene
-
Angiopoietins are proteins with important roles in vascular development and angiogenesis. All angiopoietins bind with similar affinity to an endothelial cell-specific tyrosine-protein kinase receptor. The mechanism by which they contribute to angiogenesis is thought to involve regulation of endothelial cell interactions with supporting perivascular cells. The protein encoded by this gene functions as an agonist and is an angiopoietin. [provided by RefSeq, Jul 2008]
GeneCards Summary for ANGPT4 Gene
ANGPT4 (Angiopoietin 4) is a Protein Coding gene. Among its related pathways are PEDF Induced Signaling and Immune response IL-23 signaling pathway. GO annotations related to this gene include receptor tyrosine kinase binding and transmembrane receptor protein tyrosine kinase activator activity. An important paralog of this gene is ANGPT1.
UniProtKB/Swiss-Prot for ANGPT4 Gene
-
Binds to TEK/TIE2, modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2. Promotes endothelial cell survival, migration and angiogenesis.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANGPT4 Gene
Genomics for ANGPT4 Gene
Regulatory Elements for ANGPT4 Gene
Enhancers for ANGPT4 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH20G000890 | 0.9 | Ensembl ENCODE | 19.3 | +25.1 | 25059 | 1.1 | MTA2 GATAD2B NR3C1 TBX21 SMARCA4 POLR2A ZNF239 IKZF1 IKZF2 | ANGPT4 LOC105372492 GC20M000856 |
| GH20G000727 | 1.5 | Ensembl ENCODE dbSUPER | 10.4 | +187.9 | 187891 | 1.3 | ATF1 ARID4B ZNF48 GLIS2 CBX5 ZNF143 ZNF263 SP5 MIER2 REST | SCRT2 SRXN1 SLC52A3 CSNK2A1 ANGPT4 SOX12 GC20P000743 PIR59185 |
| GH20G000840 | 1.3 | FANTOM5 ENCODE | 10.8 | +71.8 | 71755 | 7.5 | ATF1 PKNOX1 ARNT SIN3A GLIS2 ZNF766 ELK1 SP3 NCOA1 ZHX2 | FAM110A ANGPT4 RSPO4 RPS10P5 PIR36894 |
| GH20G000855 | 1.1 | Ensembl ENCODE | 10.9 | +60.1 | 60118 | 1.9 | PKNOX1 NFIB ARNT SIN3A TCF12 GLIS2 EGR1 ZNF366 RCOR1 FOS | FAM110A ANGPT4 GC20M000856 GC20M000847 PIR34196 |
| GH20G000766 | 1.1 | Ensembl ENCODE | 10.4 | +147.6 | 147625 | 3.5 | ATF1 KLF17 ZBTB40 RAD21 ETS1 ZNF143 FOS CREM THAP11 ZNF263 | SLC52A3 RSPO4 ANGPT4 GC20P000743 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around ANGPT4 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the ANGPT4 gene promoter:
Regulatory Element Products
Genomic Location for ANGPT4 Gene
- Chromosome:
- 20
- Start:
- 869,899 bp from pter
- End:
- 916,375 bp from pter
- Size:
- 46,477 bases
- Orientation:
- Minus strand
Genomic View for ANGPT4 Gene
Genes around ANGPT4 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 20p13 by Ensembl
- 20p13 by Entrez Gene
- 20p13 by HGNC
ANGPT4 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ANGPT4 Gene
Proteins for ANGPT4 Gene
-
Protein details for ANGPT4 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9Y264-ANGP4_HUMAN
- Recommended name:
- Angiopoietin-4
- Protein Accession:
- Q9Y264
- B4E3J9
- Q5TFF4
- Q9H4Z4
Protein attributes for ANGPT4 Gene
- Size:
- 503 amino acids
- Molecular mass:
- 56849 Da
- Quaternary structure:
-
- Homodimer; disulfide-linked. Interacts with TEK/TIE2.
Protein Expression for ANGPT4 Gene
Post-translational modifications for ANGPT4 Gene
Other Protein References for ANGPT4 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for ANGPT4
- R&D Systems Antibodies for ANGPT4 (Angiopoietin-4)
- Novus Biologicals Antibodies for ANGPT4
-
Abcam antibodies for ANGPT4
-
Cloud-Clone Corp. Antibodies for ANGPT4
- Invitrogen Antibodies for ANGPT4
- antibodies-online Antibodies for ANGPT4: See all 56
- GeneTex ANGPT4 antibody for ANGPT4
Protein Products
- R&D Systems Proteins and Enzymes for ANGPT4 (Angiopoietin-4)
-
OriGene Purified Proteins for ANGPT4
- Search Origene for MassSpec and Protein Over-expression Lysates for ANGPT4
- Origene Custom Protein Services for ANGPT4
- Sino Biological Recombinant Proteins for ANGPT4
- Sino Biological Cell Lysates for ANGPT4
-
Cloud-Clone Corp. Proteins for ANGPT4
- antibodies-online Proteins for ANGPT4: See all 12
- Search antibodies-online for peptides
- Search GeneTex for Proteins for ANGPT4
-
Abcam proteins for ANGPT4
Assay Products
- R&D Systems ELISAs and other biochemical assays for ANGPT4 (Angiopoietin-4)
-
Cloud-Clone Corp Assay Kits for ANGPT4
- antibodies-online Kits for ANGPT4: See all 40
-
Abcam assays for ANGPT4
No data available for DME Specific Peptides for ANGPT4 Gene
Domains & Families for ANGPT4 Gene
Gene Families for ANGPT4 Gene
Protein Domains for ANGPT4 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for ANGPT4 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for ANGPT4 Gene
Function for ANGPT4 Gene
Molecular function for ANGPT4 Gene
- GENATLAS Biochemistry:
- angiopoietin 4 secreted ligand for the vascular endothelial restricted receptor tyrosine kinase TEK,including phosphorylation of TEK,promoting angiogenic remodeling as well as vessel maturation and stabilization,predominantly expressed in lung
- UniProtKB/Swiss-Prot Function:
- Binds to TEK/TIE2, modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2. Promotes endothelial cell survival, migration and angiogenesis.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0030297 | transmembrane receptor protein tyrosine kinase activator activity | IDA | 10051567 |
| GO:0030971 | receptor tyrosine kinase binding | IDA | 10051567 |
Phenotypes for ANGPT4 Gene
- GenomeRNAi human phenotypes for ANGPT4:
-
- Increased viability
- Increased vaccinia virus (VACV) infection
- Increased gamma-H2AX phosphorylation
- Decreased viability in esophageal squamous lineage
- Increased transferrin (TF) endocytosis
- Decreased POU5F1-GFP protein expression
- Decreased viability
- Decreased Salmonella enterica Typhimurium invasion
- Decreased OCT4 protein expression
- Decreased NANOG protein expression
- Condensed cis-Golgi
- Decreased telomerase activity
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for ANGPT4
-
-
ViGene Biosciences lentiviral particle packaged cDNA for ANGPT4 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for ANGPT4 gene
- Search ViGene Biosciences for ANGPT4
CRISPR Products
-
OriGene CRISPR knockouts for ANGPT4
-
Santa Cruz Biotechnology (SCBT) CRISPR for ANGPT4
- GenScript: Design CRISPR guide RNA sequences for ANGPT4
miRNA for ANGPT4 Gene
- miRTarBase miRNAs that target ANGPT4
-
- hsa-mir-335-5p (MIRT016991)
- hsa-mir-6510-3p (MIRT607731)
- hsa-mir-6736-5p (MIRT607732)
- hsa-mir-4701-3p (MIRT607733)
- hsa-mir-1262 (MIRT607734)
- hsa-mir-7703 (MIRT607735)
- hsa-mir-6864-3p (MIRT607736)
- hsa-mir-3672 (MIRT607737)
- hsa-mir-6888-3p (MIRT607738)
- hsa-mir-6720-5p (MIRT607739)
- hsa-mir-6512-3p (MIRT607740)
- hsa-mir-542-3p (MIRT607741)
- hsa-mir-661 (MIRT607742)
- hsa-mir-4252 (MIRT607743)
- hsa-mir-873-3p (MIRT607744)
- hsa-mir-4522 (MIRT607745)
- hsa-mir-3120-5p (MIRT607746)
- hsa-mir-6776-5p (MIRT607747)
- hsa-mir-4793-3p (MIRT607748)
- hsa-mir-766-3p (MIRT607749)
- hsa-mir-372-5p (MIRT607750)
- hsa-mir-371a-5p (MIRT607751)
- hsa-mir-616-5p (MIRT607752)
- hsa-mir-373-5p (MIRT607753)
- hsa-mir-371b-5p (MIRT607754)
- hsa-mir-6742-3p (MIRT607755)
- hsa-mir-6849-3p (MIRT607756)
- hsa-mir-1273g-3p (MIRT607757)
- hsa-mir-759 (MIRT607758)
- hsa-mir-5586-3p (MIRT607759)
- hsa-mir-3664-5p (MIRT607760)
- hsa-mir-508-5p (MIRT607761)
- hsa-mir-4797-5p (MIRT607762)
- hsa-mir-665 (MIRT662479)
- hsa-mir-6513-5p (MIRT662480)
- hsa-mir-887-5p (MIRT662481)
- hsa-mir-3913-5p (MIRT662482)
- hsa-mir-3122 (MIRT662483)
- hsa-mir-450a-1-3p (MIRT662484)
- hsa-mir-6780a-5p (MIRT662485)
- hsa-mir-6779-5p (MIRT662486)
- hsa-mir-3689c (MIRT662487)
- hsa-mir-3689b-3p (MIRT662488)
- hsa-mir-3689a-3p (MIRT662489)
- hsa-mir-30b-3p (MIRT662490)
- hsa-mir-1273h-5p (MIRT662491)
- hsa-mir-6788-5p (MIRT662492)
- hsa-mir-30c-2-3p (MIRT662493)
- hsa-mir-30c-1-3p (MIRT662494)
- hsa-mir-7977 (MIRT662495)
- hsa-mir-3165 (MIRT662496)
- hsa-mir-6799-5p (MIRT662497)
- hsa-mir-6883-5p (MIRT662498)
- hsa-mir-6785-5p (MIRT662499)
- hsa-mir-4728-5p (MIRT662500)
- hsa-mir-149-3p (MIRT662501)
- hsa-mir-7106-5p (MIRT662502)
- hsa-mir-4736 (MIRT662503)
- hsa-mir-7160-5p (MIRT662504)
- hsa-mir-3665 (MIRT662505)
- hsa-mir-6884-5p (MIRT662506)
- hsa-mir-485-5p (MIRT662507)
- hsa-mir-6089 (MIRT662508)
- hsa-mir-5008-5p (MIRT662509)
- hsa-mir-1827 (MIRT662510)
- hsa-mir-4649-3p (MIRT662511)
- hsa-mir-383-3p (MIRT662512)
- hsa-mir-4717-3p (MIRT662513)
- hsa-mir-4478 (MIRT662514)
- hsa-mir-4419b (MIRT662515)
- hsa-mir-3929 (MIRT662516)
- hsa-mir-940 (MIRT662517)
- hsa-mir-6893-5p (MIRT662518)
- hsa-mir-6808-5p (MIRT662519)
- hsa-mir-133b (MIRT709495)
- hsa-mir-133a-3p (MIRT709496)
- hsa-mir-5587-5p (MIRT709497)
- hsa-mir-6716-5p (MIRT709498)
miRNA Products
- Search ViGene Biosciences for ANGPT4
Inhibitory RNA Products
- Origene shRNA, RNAi, and siRNA products in human, mouse, rat for ANGPT4
- Browse OriGene Inhibitory RNA Products For ANGPT4
-
ViGene Biosciences ready-to-package AAV shRNAs for ANGPT4 gene
Clone Products
-
OriGene ORF clones in human for ANGPT4
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for ANGPT4
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for ANGPT4
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ANGPT4
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for ANGPT4
-
ViGene Biosciences adenoviral particle packaged cDNA for ANGPT4 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for ANGPT4 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for ANGPT4 gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ANGPT4 Gene
Localization for ANGPT4 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ANGPT4 Gene
- Secreted.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| nucleus | 2 |
| endoplasmic reticulum | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | TAS | -- |
| GO:0005615 | extracellular space | IDA | 10025962 |
Pathways & Interactions for ANGPT4 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | PEDF Induced Signaling |
.61
|
.47
|
| 2 | TGF-Beta Pathway |
.60
.57
|
.51
.40
|
| 3 | Immune response IL-23 signaling pathway | ||
| 4 | Akt Signaling |
.60
.60
|
|
| 5 | ERK Signaling |
.61
|
|
Pathways by source for ANGPT4 Gene
2 BioSystems pathways for ANGPT4 Gene
3 Reactome pathways for ANGPT4 Gene
4 KEGG pathways for ANGPT4 Gene
1 GeneGo (Thomson Reuters) pathway for ANGPT4 Gene
26 Qiagen pathways for ANGPT4 Gene
Interacting Proteins for ANGPT4 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001525 | angiogenesis | IEA | -- |
| GO:0001935 | NOT endothelial cell proliferation | IDA | 10025962 |
| GO:0007171 | activation of transmembrane receptor protein tyrosine kinase activity | IEA | -- |
| GO:0007219 | Notch signaling pathway | IEA | -- |
| GO:0010595 | positive regulation of endothelial cell migration | IDA | 12958144 |
Transcripts for ANGPT4 Gene
mRNA/cDNA for ANGPT4 Gene
- (3) REFSEQ mRNAs :
- (5) Additional mRNA sequences :
- (4) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for ANGPT4
-
Santa Cruz Biotechnology (SCBT) CRISPR for ANGPT4
- GenScript: Design CRISPR guide RNA sequences for ANGPT4
miRNA Products
- Search ViGene Biosciences for ANGPT4
Inhibitory RNA Products
- Origene shRNA, RNAi, and siRNA products in human, mouse, rat for ANGPT4
- Browse OriGene Inhibitory RNA Products For ANGPT4
-
ViGene Biosciences ready-to-package AAV shRNAs for ANGPT4 gene
Clone Products
-
OriGene ORF clones in human for ANGPT4
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for ANGPT4
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for ANGPT4
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ANGPT4
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
Expression for ANGPT4 Gene
mRNA differential expression in normal tissues according to GTEx for ANGPT4 Gene
This gene is overexpressed in Adipose - Subcutaneous (x5.8), Adipose - Visceral (Omentum) (x5.1), Breast - Mammary Tissue (x4.3), and Cervix - Endocervix (x4.1).
This gene is overexpressed in Placenta (59.6) and Platelet (7.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ANGPT4 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of ANGPT4 Gene:
ANGPT4SOURCE GeneReport for Unigene cluster for ANGPT4 Gene:
Hs.278973mRNA Expression by UniProt/SwissProt for ANGPT4 Gene:
Q9Y264-ANGP4_HUMAN
Tissue specificity:
Highly expressed in the lung with much lower levels found in other tissues.
Primer Products
-
OriGene qPCR primer pairs for ANGPT4
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ANGPT4 Gene
Orthologs for ANGPT4 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ANGPT4 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | ANGPT4 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | ANGPT4 34 |
|
||
| ANGPTL4 35 |
|
OneToOne | |||
| rat (Rattus norvegicus) |
Mammalia | Angpt4 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Angpt4 34 16 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | ANGPT4 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 35 |
|
ManyToMany | |
| chicken (Gallus gallus) |
Aves | ANGPT4 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | ANGPT4 35 |
|
OneToOne | |
| zebrafish (Danio rerio) |
Actinopterygii | angpt4 35 |
|
OneToOne | |
| fruit fly (Drosophila melanogaster) |
Insecta | CG10359 36 |
|
|
|
| CG9500 36 |
|
|
|||
| sca 36 |
|
|
- Species where no ortholog for ANGPT4 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for ANGPT4 Gene
Paralogs for ANGPT4 Gene
(12) SIMAP similar genes for ANGPT4 Gene using alignment to 2 proteins:
Variants for ANGPT4 Gene
| SNP ID | Clin | Chr 20 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000034916 | -- | 909,610(+) | ACATG(G/T)GCATT | intron-variant | |
| rs1000065959 | -- | 907,468(+) | TGGGA(C/G)GTGTT | intron-variant | |
| rs1000100866 | -- | 871,723(+) | TGGGG(A/G)AGTTG | utr-variant-3-prime | |
| rs1000148070 | -- | 907,320(+) | AGAAG(A/G)TGAGG | intron-variant | |
| rs1000159103 | -- | 897,593(+) | TTCCA(C/T)TGGTG | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv274947 | CNV | gain+loss | 21479260 |
| esv3575346 | CNV | gain | 25503493 |
| esv3584405 | CNV | loss | 25503493 |
| esv3644952 | CNV | gain | 21293372 |
| esv3644964 | CNV | gain | 21293372 |
| esv3644966 | CNV | gain | 21293372 |
| nsv1058339 | CNV | loss | 25217958 |
| nsv1062082 | CNV | gain | 25217958 |
| nsv1062764 | CNV | loss | 25217958 |
| nsv1067424 | CNV | gain | 25217958 |
| nsv458848 | CNV | loss | 19166990 |
| nsv510778 | CNV | deletion | 20534489 |
| nsv585191 | CNV | gain | 21841781 |
| nsv585193 | CNV | gain | 21841781 |
| nsv585194 | CNV | loss | 21841781 |
| nsv817879 | CNV | gain | 17921354 |
Residual Variation Intolerance Score:
52.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.57;
56.00% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for ANGPT4 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- ANGPT4
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANGPT4 Gene
Disorders for ANGPT4 Gene
Relevant External Links for ANGPT4
No disorders were found for ANGPT4 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANGPT4 Gene
Publications for ANGPT4 Gene
- Angiopoietins 3 and 4: diverging gene counterparts in mice and humans. (PMID: 10051567) Valenzuela D.M. … Yancopoulos G.D. (Proc. Natl. Acad. Sci. U.S.A. 1999) 2 3 4 22 64
- Biological characterization of angiopoietin-3 and angiopoietin-4. (PMID: 15284220) Lee H.J. … Koh G.Y. (FASEB J. 2004) 3 4 22 64
- Angiopoietin-3, a novel member of the angiopoietin family. (PMID: 10218486) Nishimura M. … Seino S. (FEBS Lett. 1999) 2 3 4 64
- Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
- MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer. (PMID: 20819778) Zhang X. … Wu X. (Carcinogenesis 2010) 3 46 64
Products for ANGPT4 Gene
- R&D Systems Antibodies for ANGPT4 (Angiopoietin-4)
- R&D Systems Proteins and Enzymes for ANGPT4 (Angiopoietin-4)
- R&D Systems ELISAs and other biochemical assays for ANGPT4 (Angiopoietin-4)
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for ANGPT4
- Search Origene for MassSpec and Protein Over-expression Lysates for ANGPT4
- Origene Custom Protein Services for ANGPT4
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- OriGene ORF clones in human for ANGPT4
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- GenScript: Next-day shipping cDNA ORF clone for ANGPT4 in any vector
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- GenScript: Design CRISPR guide RNA sequences for ANGPT4
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- CloneReady with Over 120,000 Genes
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- Sino Biological Human cDNA Clone for ANGPT4
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- Sino Biological Antibodies
- Sino Biological ELISA Kits and Pair Sets
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- Novus Biologicals Antibodies for ANGPT4
- Novus Biologicals proteins and lysates for ANGPT4
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Abcam antibodies for ANGPT4
- Abcam proteins for ANGPT4
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- Find your target
- Search knockout validated antibodies
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- Cloud-Clone Corp. Antibodies for ANGPT4
- Cloud-Clone Corp. Proteins for ANGPT4
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- antibodies-online Antibodies for ANGPT4: See all 56
- antibodies-online Kits for ANGPT4: See all 40
- antibodies-online Proteins for ANGPT4: See all 12
- Search antibodies-online for peptides
- GeneTex ANGPT4 antibody for ANGPT4
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- ViGene Biosciences adenoviral particle packaged cDNA for ANGPT4 gene
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- Search ViGene Biosciences for ANGPT4
- Horizon Cell Lines for ANGPT4
- Cyagen custom Knockout/knockin (KOKI) mouse models for ANGPT4
- VectorBuilder custom plasmid, inducible vectors for ANGPT4
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ANGPT4
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for ANGPT4 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer