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ANGPT4 Gene

protein-coding   GIFtS: 63
GCID: GC20M000853

Angiopoietin 4

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Angiopoietin 41 2     angiopoietin-32
ANG42 3 5     angiopoietin-42
ANG-32 3     DJ824F16.2 (Angiopoietin 4)2
ANG-42 3     ANG33
AGP42     Angiopoietin-33

External Ids:    HGNC: 4871   Entrez Gene: 513782   Ensembl: ENSG000001012807   OMIM: 6037055   UniProtKB: Q9Y2643   

Export aliases for ANGPT4 gene to outside databases

Previous GC identifers: GC20M000841 GC20M000848 GC20M000801 GC20M000805


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ANGPT4 Gene:
Angiopoietins are proteins with important roles in vascular development and angiogenesis. All angiopoietins bind
with similar affinity to an endothelial cell-specific tyrosine-protein kinase receptor. The mechanism by which
they contribute to angiogenesis is thought to involve regulation of endothelial cell interactions with supporting
perivascular cells. The protein encoded by this gene functions as an agonist and is an angiopoietin. (provided by
RefSeq, Jul 2008)

GeneCards Summary for ANGPT4 Gene:
ANGPT4 (angiopoietin 4) is a protein-coding gene. Diseases associated with ANGPT4 include vascular dementia, and hemangioblastoma. GO annotations related to this gene include transmembrane receptor protein tyrosine kinase activator activity and receptor tyrosine kinase binding. An important paralog of this gene is FGL2.

UniProtKB/Swiss-Prot: ANGP4_HUMAN, Q9Y264
Function: Binds to TEK/TIE2, modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2.
Promotes endothelial cell survival, migration and angiogenesis

Gene Wiki entry for ANGPT4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000020.11  NT_011387.9  NC_018931.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ANGPT4 gene promoter:
         STAT5B   Nkx3-1 v4   C/EBPbeta   LUN-1   AP-4   Evi-1   FAC1   FOXJ2 (long isoform)   Nkx3-1 v3   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidANGPT4 promoter sequence
   Search Chromatin IP Primers for ANGPT4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ANGPT4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20p13   Ensembl cytogenetic band:  20p13   HGNC cytogenetic band: 20p13

ANGPT4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ANGPT4 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M000853:  view genomic region     (about GC identifiers)

Start:
853,296 bp from pter      End:
896,977 bp from pter
Size:
43,682 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ANGP4_HUMAN, Q9Y264 (See protein sequence)
Recommended Name: Angiopoietin-4 precursor  
Size: 503 amino acids; 56849 Da
Subunit: Homodimer; disulfide-linked. Interacts with TEK/TIE2
Secondary accessions: Q5TFF4 Q9H4Z4

Explore the universe of human proteins at neXtProt for ANGPT4: NX_Q9Y264

Explore proteomics data for ANGPT4 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn96, Asn126, Asn140, Asn158, Asn247, Asn274, Asn311, Asn337, Asn427

  • See ANGPT4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_057069.1  
    ENSEMBL proteins: 
     ENSP00000371347   ENSP00000439605  
    Reactome Protein details: Q9Y264

    ANGPT4 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    FIBC: Fibrinogen C domain containing

    5 InterPro protein domains:
     IPR028845 Ang-4
     IPR014715 Fibrinogen_a/b/g_C_2
     IPR014716 Fibrinogen_a/b/g_C_1
     IPR020837 Fibrinogen_CS
     IPR002181 Fibrinogen_a/b/g_C_dom

    Graphical View of Domain Structure for InterPro Entry Q9Y264

    ProtoNet protein and cluster: Q9Y264

    1 Blocks protein domain: IPB002181 Fibrinogen

    UniProtKB/Swiss-Prot: ANGP4_HUMAN, Q9Y264
    Similarity: Contains 1 fibrinogen C-terminal domain


    ANGPT4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ANGP4_HUMAN, Q9Y264
    Function: Binds to TEK/TIE2, modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2.
    Promotes endothelial cell survival, migration and angiogenesis

         Genatlas biochemistry entry for ANGPT4:
    angiopoietin 4 secreted ligand for the vascular endothelial restricted receptor tyrosine kinase TEK,including
    phosphorylation of TEK,promoting angiogenic remodeling as well as vessel maturation and
    stabilization,predominantly expressed in lung

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0030297transmembrane receptor protein tyrosine kinase activator activity IDA10051567
    GO:0030971receptor tyrosine kinase binding IDA10051567
         
    ANGPT4 for ontologies           About GeneDecksing


    Phenotypes:
         6 GenomeRNAi human phenotypes for ANGPT4:
     Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e  Decreased Salmonella enterica  
     Decreased telomerase activity  Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ANGPT4
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    miRTarBase miRNAs that target ANGPT4:
    hsa-mir-335-5p (MIRT016991)

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    6 qRT-PCR Assays for microRNAs that regulate ANGPT4:
    hsa-miR-422a hsa-miR-149 hsa-miR-378c hsa-miR-378 hsa-miR-24 hsa-miR-378b
    SwitchGear 3'UTR luciferase reporter plasmidANGPT4 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ANGP4_HUMAN, Q9Y264: Secreted (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    nucleus2
    endoplasmic reticulum1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IDA10025962

    ANGPT4 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ANGPT4 About   (see all 11)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Immune response IL 23 signaling pathway
    Development Angiopoietin Tie2 signaling0.38
    Angiopoietin receptor Tie2-mediated signaling0.32
    Angiopoietin-TIE2 Signaling0.36
    2PEDF Induced Signaling
    MIF Regulation of Innate Immune Cells0.94
    NFAT Signaling and Lymphocyte Interactions0.57
    MIF Mediated Glucocorticoid Regulation0.94
    PGC1Alpha Pathway0.51
    PEDF Induced Signaling0.73
    STAT3 Pathway0.47
    all-trans-Retinoic Acid Signaling in Brain0.71
    Endothelin-1 Signaling Pathway0.46
    3TGF-Beta Pathway
    TGF-Beta Pathway0.60
    JNK Pathway0.51
    MAPK Family Pathway0.60
    Regulation of eIF4 and p70S6K0.43
    JAK-STAT Pathway0.57
    SOCS Pathway0.40
    4Akt Signaling
    Akt Signaling0.60
    Tec Kinases Signaling0.55
    p38 Signaling0.60
    5ERK Signaling
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for ANGPT4 (see all 26)
        Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    NFAT Signaling and Lymphocyte Interactions
    JNK Pathway

    1 GeneGo (Thomson Reuters) Pathway for ANGPT4
        Development Angiopoietin - Tie2 signaling

    1 BioSystems Pathway for ANGPT4
        Angiopoietin receptor Tie2-mediated signaling


    1 Reactome Pathway for ANGPT4
        Tie2 Signaling


    4 Kegg Pathways  (Kegg details for ANGPT4):
        Ras signaling pathway
    Rap1 signaling pathway
    HIF-1 signaling pathway
    PI3K-Akt signaling pathway


    ANGPT4 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ANGPT4
    Interactions:

        Search GeneGlobe Interaction Network for ANGPT4

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for ANGPT4 (Q9Y2643 ENSP000003713474) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TEKQ027633, ENSP000003839774I2D: score=4 STRING: ENSP00000383977
    TIE1P355903, ENSP000003615544I2D: score=1 STRING: ENSP00000361554
    ANGPT2ENSP000003148974STRING: ENSP00000314897
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis IEA--
    GO:0001935NOT endothelial cell proliferation IDA10025962
    GO:0007171activation of transmembrane receptor protein tyrosine kinase activity IDA10051567
    GO:0007596blood coagulation TAS--
    GO:0010595positive regulation of endothelial cell migration IDA12958144

    ANGPT4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ANGPT4 (ANGP4)

    2 Novoseek inferred chemical compound relationships for ANGPT4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    vegf 55.5 5 12958144 (1), 15198927 (1), 16685428 (1)
    tyrosine 35.9 2 19449109 (1), 15284220 (1)



    ANGPT4 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ANGPT4 gene: 
    NM_015985.2  

    Unigene Cluster for ANGPT4:

    Angiopoietin 4
    Hs.278973  [show with all ESTs]
    Unigene Representative Sequence: AF074332
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000381922(uc002wei.3 uc010zpn.2) ENST00000546022

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    hsa-miR-422a hsa-miR-149 hsa-miR-378c hsa-miR-378 hsa-miR-24 hsa-miR-378b
    SwitchGear 3'UTR luciferase reporter plasmidANGPT4 3' UTR sequence
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    Additional mRNA sequence: 

    AF074332.1 AF113708.1 AK304756.1 BC111976.1 BC111978.1 

    1 DOTS entry:

    DT.92060866 

    4 AceView cDNA sequences:

    NM_015985 AF113708 AF074332 BG011154 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ANGPT4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGGGTGTTC
    ANGPT4 Expression
    About this image

    ANGPT4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ANGPT4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.278973

    UniProtKB/Swiss-Prot: ANGP4_HUMAN, Q9Y264
    Tissue specificity: Highly expressed in the lung with much lower levels found in other tissues

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ANGPT4 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Angpt41 , 5 angiopoietin 41, 5 70.82(n)1
    56.14(a)1
      2 (74.83 cM)5
    116021  NM_009641.11  NP_033771.11 
     1519112105 
    chicken
    (Gallus gallus)
    Aves ANGPT41 angiopoietin 4 68.53(n)
    55.28(a)
      771763  XM_004947146.1  XP_004947203.1 
    lizard
    (Anolis carolinensis)
    Reptilia ANGPT46
    angiopoietin 4
    55(a)
    1 ↔ 1
    GL343346.1(423369-435343)
    zebrafish
    (Danio rerio)
    Actinopterygii angpt46
    angiopoietin 4
    44(a)
    1 ↔ 1
    6(51815743-51984937) ENSDARG00000076787


    ENSEMBL Gene Tree for ANGPT4 (if available)
    TreeFam Gene Tree for ANGPT4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ANGPT4 gene
    FGL22  FGG2  FIBCD12  ANGPTL62  FCN32  ANGPTL22  FCN22  FCN12  
    ANGPT12  ANGPTL12  ANGPTL72  FGB2  ANGPT22  MFAP42  FGL12  
    12 SIMAP similar genes for ANGPT4 using alignment to 2 protein entries:     ANGP4_HUMAN (see all proteins):
    ANGPT1    FCN3    ANGPT2    MFAP4    FCN1    FGL1
    FCN2    AngA    ANGPTL2    ANGPTL7    angiopoietin-2    ANGPTL1

    ANGPT4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ANGPT4 (see all 1285)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs60554581,2
    C,F,A,H--852847(+) TTCTCA/GTTGCT 1 -- ds500121Minor allele frequency- G:0.25NS EA NA WA CSA 2345
    rs1830455181,2
    --852870(+) TAGAGA/GCAAGC 1 -- ds50010--------
    rs1163359591,2
    C,F--852917(+) CTGGAG/AGTGAA 1 -- ds50011Minor allele frequency- A:0.03WA 118
    rs754848361,2
    C--852926(+) AAGGAG/TCATGT 1 -- ds50010--------
    rs60389981,2
    H--852975(+) GGAGCC/TTAGAA 1 -- ds50014Minor allele frequency- T:0.00NS EA 418
    rs1418940021,2
    --852992(+) AAGTGG/TTAAAG 1 -- ds50010--------
    rs285164491,2
    F--853078(+) AATAAT/AGATTA 1 -- ds50012Minor allele frequency- A:0.11NA 122
    rs130440641,2
    C,F--853093(+) ACCCAT/CTAAGG 1 -- ds500113Minor allele frequency- C:0.37NA WA CSA EA 376
    rs1506404481,2
    --853239(+) CTTCCA/GATGTG 1 -- ds50010--------
    rs2005475251,2
    C--853305(+) GTCTG-/TTCTCA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for ANGPT4 (853296 - 896977 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for ANGPT4:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv912583CNV Loss21882294
    nsv510778CNV Loss20534489
    nsv912582CNV Loss21882294
    nsv458848CNV Loss19166990
    nsv912584CNV Loss21882294
    nsv912580CNV Gain21882294
    nsv817879CNV Gain17921354
    esv274947CNV Gain+Loss21479260

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603705    OMIM disorders: --

    14 diseases for ANGPT4:    About MalaCards
    vascular dementia    hemangioblastoma    angiosarcoma    renal clear cell carcinoma
    gastrointestinal stromal tumor    endotheliitis    leiomyoma    dementia
    kaposi's sarcoma    hypoxia    sarcoma    alzheimer's disease
    breast cancer    thyroiditis


    ANGPT4 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    5 Novoseek inferred disease relationships for ANGPT4 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    carcinoma renal cell 27.3 1 12434420 (1)
    metastasis 6.37 1 17381833 (1)
    breast cancer 0 3 11309342 (1), 17381833 (1)
    tumors 0 3 11309342 (3)
    cancer 0 3 17381833 (2)

    Genetic Association Database (GAD): ANGPT4
    Human Genome Epidemiology (HuGE) Navigator: ANGPT4 (5 documents)

    Export disorders for ANGPT4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ANGPT4 gene, integrated from 10 sources (see all 36):
    (articles sorted by number of sources associating them with ANGPT4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Angiopoietins 3 and 4: diverging gene counterparts in mice and humans. (PubMed id 10051567)1, 2, 3, 9 Valenzuela D.M....Yancopoulos G.D. (Proc. Natl. Acad. Sci. U.S.A. 1999)
    2. Angiopoietin-3, a novel member of the angiopoietin family. (PubMed id 10218486)1, 2, 3 Nishimura M....Seino S. (FEBS Lett. 1999)
    3. Biological characterization of angiopoietin-3 and angiopoietin-4. (PubMed id 15284220)1, 2, 9 Lee H.J.... Koh G.Y. (FASEB J. 2004)
    4. MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer. (PubMed id 20819778)1, 4 Zhang X....Wu X. (Carcinogenesis 2010)
    5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    6. Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's disease. (PubMed id 19204726)1, 4 Chapuis J....Lambert J.C. (Mol. Psychiatry 2009)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (Nature 2001)
    9. Hypoxia-inducible factor-1 mediates activation of cultured vascular endothelial cells by inducing multiple angiogenic factors. (PubMed id 12958144)1, 9 Yamakawa M....Jiang C. (Circ. Res. 2003)
    10. Expression of angiopoietins in renal epithelial and clear cell carcinoma cells: regulation by hypoxia and participation in angiogenesis. (PubMed id 15198927)1, 9 Yamakawa M....Jiang C. (Am. J. Physiol. Renal Physiol. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 51378 HGNC: 487 AceView: ANGPT4 Ensembl:ENSG00000101280 euGenes: HUgn51378
    ECgene: ANGPT4 Kegg: 51378 H-InvDB: ANGPT4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ANGPT4 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ANGPT4 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for ANGPT4 gene:
    Search GeneIP for patents involving ANGPT4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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