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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ANGPT4 Gene

protein-coding   GIFtS: 62
GCID: GC20M000853

angiopoietin 4
 Explore 15 diseases affiliated with
ANGPT4 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ANGPT4    

Aliases
for ANGPT4 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Angiopoietin 41 2     Angiopoietin-33
ANG42 3 5     Angiopoietin-41
ANG-32 3     DJ824F16.2 (Angiopoietin 4)2
ANG-42 3     ANG33
AGP42     Angiopoietin-33

External Ids:    HGNC: 4871   Entrez Gene: 513782   Ensembl: ENSG000001012807   OMIM: 6037055   UniProtKB: Q9Y2643   

Export aliases for ANGPT4 gene to outside databases

Previous GC identifers: GC20M000841 GC20M000848 GC20M000801 GC20M000805


Summaries
for ANGPT4 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for ANGPT4:
Angiopoietins are proteins with important roles in vascular development and angiogenesis. All angiopoietins bind with
similar affinity to an endothelial cell-specific tyrosine-protein kinase receptor. The mechanism by which they
contribute to angiogenesis is thought to involve regulation of endothelial cell interactions with supporting
perivascular cells. The protein encoded by this gene functions as an agonist and is an angiopoietin. (provided by
RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: ANGP4_HUMAN, Q9Y264
Function: Binds to TEK/TIE2, modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2. Promotes
endothelial cell survival, migration and angiogenesis

Gene Wiki entry for ANGPT4


Genomic Views
for ANGPT4 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000020.10  NC_018931.1  NT_011387.8  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ANGPT4 gene promoter:
         STAT5B   Nkx3-1 v4   C/EBPbeta   LUN-1   AP-4   Evi-1   FAC1   FOXJ2 (long isoform)   Nkx3-1 v3   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ANGPT4 promoter sequence
   Search SABiosciences Chromatin IP Primers for ANGPT4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ANGPT4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20p13   Ensembl cytogenetic band:  20p13   HGNC cytogenetic band: 20p13

ANGPT4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ANGPT4 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M000853:  view genomic region     (about GC identifiers)

Start:
 853,296 bp from pter      End:
 896,977 bp from pter
Size:
 43,682 bases      Orientation:
 minus strand

Proteins
for ANGPT4 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ANGP4_HUMAN, Q9Y264 (See protein sequence)
Recommended Name: Angiopoietin-4 precursor  
Size: 503 amino acids; 56849 Da
Subunit: Homodimer; disulfide-linked. Interacts with TEK/TIE2
Subcellular location: Secreted (Probable)
Secondary accessions: Q5TFF4 Q9H4Z4

Explore the universe of human proteins at neXtProt for ANGPT4: NX_Q9Y264

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9Y264

    • ANGPT4 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_057069.1  
    ENSEMBL proteins: 
     ENSP00000371347   ENSP00000439605  
    Reactome Protein details: Q9Y264
    Human Recombinant Protein Products: 
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    R&D Systems Recombinant & Natural Proteins for ANGPT4 (Angiopoietin-4)
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    OriGene Protein Over-expression Lysate: ANGPT4
    OriGene Custom Protein Services for ANGPT4 
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    Novus Biologicals ANGPT4 Protein
    Novus Biologicals ANGPT4 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for ANGPT4

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IDA10025962


    ANGPT4 for ontologies           About GeneDecksing



    ANGPT4 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of ANGPT4
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    Uscn Antibodies for ANGPT4
    ThermoFisher Antibodies for ANGPT4

    Assay Products for ANGPT4: 
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    Uscn ELISAs and CLIAs for ANGPT4

    Protein Domains /
    Families
    for ANGPT4 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ANGPT4 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR020837 Fibrinogen_CS
     IPR014715 Fibrinogen_a/b/g_C_2
     IPR002181 Fibrinogen_a/b/g_C_dom
     IPR014716 Fibrinogen_a/b/g_C_1

    Graphical View of Domain Structure for InterPro Entry Q9Y264

    ProtoNet protein and cluster: Q9Y264

    1 Blocks protein family: IPB002181 Fibrinogen

    UniProtKB/Swiss-Prot: ANGP4_HUMAN, Q9Y264
    Similarity: Contains 1 fibrinogen C-terminal domain


    Function
    for ANGPT4 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: ANGP4_HUMAN, Q9Y264
    Function: Binds to TEK/TIE2, modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2. Promotes
    endothelial cell survival, migration and angiogenesis

         Genatlas biochemistry entry for ANGPT4:
    angiopoietin 4 secreted ligand for the vascular endothelial restricted receptor tyrosine kinase TEK,including
    phosphorylation of TEK,promoting angiogenic remodeling as well as vessel maturation and stabilization,predominantly
    expressed in lung

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ANGPT4
    6 QIAGEN miScript miRNA Assays for microRNAs that regulate ANGPT4:
    hsa-miR-422a hsa-miR-149 hsa-miR-378c hsa-miR-378 hsa-miR-24 hsa-miR-378b
    SwitchGear 3'UTR luciferase reporter plasmid: ANGPT4 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ANGPT4 (see all 7)
    OriGene shRNA RFP: ANGPT4
    OriGene siRNA: ANGPT4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ANGPT4

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for ANGPT4

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ANGPT4 (see all 3)
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    GenScript: all cDNA clones in your preferred vector: ANGPT4 (NM_015985)
    Sino Biological Human cDNA Clone for ANGPT4
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ANGPT4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ANGPT4 

    Cell Line
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    Search LifeMap BioReagents cell lines for ANGPT4

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANGPT4

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding ----
    GO:0030297transmembrane receptor protein tyrosine kinase activator activity IDA10051567
    GO:0030971receptor tyrosine kinase binding IDA10051567


    ANGPT4 for ontologies           About GeneDecksing


    6 GenomeRNAi human phenotypes for ANGPT4:
     Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e  Decreased Salmonella enterica  
     Decreased telomerase activity  Increased gamma-H2AX phosphory 


    Pathways & Interactions
    for ANGPT4 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/9 super-pathways (see all 9) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1PEDF Induced Signaling
    8/11 pathways (see all 11)
    		PEDF Induced Signaling1.00
    		STAT3 Pathway0.47
    		MIF Mediated Glucocorticoid Regulation0.73
    		Endothelin-1 Signaling Pathway0.44
    		MIF Regulation of Innate Immune Cells0.71
    		NFAT Signaling and Lymphocyte Interactions0.37
    		IL-6 Pathway0.61
    		PGC1Alpha Pathway0.33
    2TGF-Beta Pathway
    		TGF-Beta Pathway1.00
    		JNK Pathway0.50
    		MAPK Family Pathway0.60
    		Regulation of eIF4 and p70S6K0.43
    		JAK-STAT Pathway0.57
    		SOCS Pathway0.29
    3Development_PDGF signaling via STATs and NF-kB
    		Development_Angiopoietin - Tie2 signaling0.38
    		Angiopoietin-TIE2 Signaling0.13
    		Development Angiopoietin - Tie2 signaling0.38
    		Angiopoietin receptor Tie2-mediated signaling0.11
    4Akt Signaling
    		Akt Signaling1.00
    		Tec Kinases Signaling0.55
    		p38 Signaling0.60
    5Rho Family GTPases
    		Rho Family GTPases1.00
    		Molecular Mechanisms of Cancer0.51
    		ERK Signaling0.61

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for ANGPT4
        Development Angiopoietin - Tie2 signaling

    5/26 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for ANGPT4 (see all 26)
        Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    NFAT Signaling and Lymphocyte Interactions
    JNK Pathway

    1 GeneGo (Thomson Reuters) Pathway for ANGPT4
        Development Angiopoietin - Tie2 signaling

    1 BioSystems Pathway for ANGPT4 
        Angiopoietin receptor Tie2-mediated signaling

    3        Reactome Pathways for ANGPT4
        Hemostasis
    Cell surface interactions at the vascular wall
    Tie2 Signaling



    ANGPT4 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ANGPT4

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for ANGPT4 (Q9Y2643 ENSP000003713474) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TEKQ027633, ENSP000003839774I2D: score=4 STRING: ENSP00000383977
    TIE1P355903, ENSP000003615544I2D: score=1 STRING: ENSP00000361554
    ANGPT2ENSP000003148974STRING: ENSP00000314897
    About this table

    Gene Ontology (GO): 5/14 biological process terms (GO ID links to tree view) (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis IEA--
    GO:0001935NOT endothelial cell proliferation IDA10025962
    GO:0007165signal transduction ----
    GO:0007171activation of transmembrane receptor protein tyrosine kinase activity IDA15851516
    GO:0007596blood coagulation TAS--


    ANGPT4 for ontologies           About GeneDecksing



    Drugs & Compounds
    for ANGPT4 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ANGPT4 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ANGPT4
    2 Novoseek chemical compound relationships for ANGPT4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    vegf 55.5 5 12958144 (1), 15198927 (1), 16685428 (1)
    tyrosine 35.9 2 19449109 (1), 15284220 (1)

    Search CenterWatch for drugs/clinical trials and news about ANGPT4 / ANGP4 

    Transcripts
    for ANGPT4 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ANGPT4 gene: 
    NM_015985.2  

    Unigene Cluster for ANGPT4:

    Angiopoietin 4
    Hs.278973  [show with all ESTs]
    Unigene Representative Sequence: AF074332
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000381922(uc002wei.3 uc010zpn.2) ENST00000546022

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ANGPT4
    6 QIAGEN miScript miRNA Assays for microRNAs that regulate ANGPT4:
    hsa-miR-422a hsa-miR-149 hsa-miR-378c hsa-miR-378 hsa-miR-24 hsa-miR-378b
    SwitchGear 3'UTR luciferase reporter plasmid: ANGPT4 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ANGPT4 (see all 7)
    OriGene shRNA RFP: ANGPT4
    OriGene siRNA: ANGPT4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ANGPT4
    Clone
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    GenScript: all cDNA clones in your preferred vector: ANGPT4 (NM_015985)
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ANGPT4
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ANGPT4

    Additional cDNA sequence: 

    AF074332.1 AF113708.1 AK304756.1 BC111976.1 BC111978.1 

    1 DOTS entry:

    DT.92060866 

    4 AceView cDNA sequences:

    NM_015985 AF074332 AF113708 BG011154 

    GeneLoc Exon Structure


    Expression
    for ANGPT4 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ANGPT4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GAGGGTGTTC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    ANGPT4 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    LiverHepatic MesenchymeMesothelial CellsLiver
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See ANGPT4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ANGPT4

    SOURCE GeneReport for Unigene cluster: Hs.278973

    UniProtKB/Swiss-Prot: ANGP4_HUMAN, Q9Y264
    Tissue specificity: Highly expressed in the lung with much lower levels found in other tissues

        SABiosciences Custom PCR Arrays for ANGPT4
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANGPT4

    Orthologs
    for ANGPT4 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for ANGPT4 gene from 4/12 species (see all 12)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves LOC7717631 angiopoietin-4-like 69.04(n)
    55.44(a)    		   771763  XM_001235002.2  XP_001235003.2 
    lizard
    (Anolis carolinensis)    		 Reptilia ANGPT46
    		 --
    		 56(a)
    		 1 ↔ 1
    		 GL343346.1(424400-435343)
    zebrafish
    (Danio rerio)    		 Actinopterygii BX324124.16
    		 --
    		 43(a)
    		 1 ↔ 1
    		 6(51815743-51984937)
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG95003   -- 38(a)
    (best of 3)    		   26C3   --


    ENSEMBL Gene Tree for ANGPT4 (if available)
    TreeFam Gene Tree for ANGPT4 (if available) 

    Paralogs
    for ANGPT4 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ANGPT4 gene
    FGL22  FGA2  FGG2  ANGPTL62  ANGPTL22  ANGPTL42  ANGPT12  ANGPTL32  
    ANGPTL12  ANGPTL72  FGB2  ANGPT22  FGL12  
    12 SIMAP similar genes for ANGPT4 using alignment to 2 protein entries:     ANGP4_HUMAN (see all proteins):
    ANGPT1    FCN3    ANGPT2    MFAP4    FCN1    FGL1
    FCN2    AngA    ANGPTL2    ANGPTL7    angiopoietin-2    ANGPTL1

    ANGPT4 for paralogs           About GeneDecksing



    Genomic Variants
    for ANGPT4 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1080 NCBI SNPs in ANGPT4 are shown (see all 1080)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 20 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs60554581,2
    		C,F,A,H,--852847(+) TTCTCA/GTTGCT 1 -- ds500121Minor allele frequency- G:0.25NS EA NA WA CSA 2345
    rs1830455181,2
    		--852870(+) TAGAGA/GCAAGC 1 -- ds50010--------
    rs1163359591,2
    		C,F,--852917(+) CTGGAG/AGTGAA 1 -- ds50011Minor allele frequency- A:0.03WA 118
    rs754848361,2
    		--852926(+) AAGGAG/TCATGT 1 -- ds50010--------
    rs60389981,2
    		H--852975(+) GGAGCC/TTAGAA 1 -- ds50014Minor allele frequency- T:0.00NS EA 418
    rs1418940021,2
    		--852992(+) AAGTGG/TTAAAG 1 -- ds50010--------
    rs285164491,2
    		--853078(+) AATAAT/AGATTA 1 -- ds50012Minor allele frequency- A:0.11NA 122
    rs130440641,2
    		C,F,--853093(+) ACCCAT/CTAAGG 1 -- ds500113Minor allele frequency- C:0.37NA WA CSA EA 376
    rs1506404481,2
    		--853239(+) CTTCCA/GATGTG 1 -- ds50010--------
    rs2005475251,2
    		--853305(+) GTCTG-/TTCTCA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for ANGPT4 (853296 - 896977 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for ANGPT4
         1 CNV: 9819

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    Disorders / Diseases
    for ANGPT4 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ANGPT4 for disorders           About GeneDecksing

    OMIM gene information: 603705    OMIM disorders: --

    15 diseases for ANGPT4:    About MalaCards
    central nervous system hemangioblastoma    gastrointestinal stromal tumor    renal clear cell carcinoma    hemangioblastoma
    vascular dementia    kaposi's sarcoma    angiosarcoma    dementia
    breast cancer    leiomyoma    sarcoma    alzheimer's disease
    glioblastoma    carcinoma    hypoxia

    5 Novoseek disease relationships for ANGPT4 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    carcinoma renal cell 27.3 1 12434420 (1)
    metastasis 6.37 1 17381833 (1)
    breast cancer 0 3 11309342 (1), 17381833 (1)
    tumors 0 3 11309342 (3)
    cancer 0 3 17381833 (2)

    Human Genome Epidemiology (HuGE) Navigator: ANGPT4 (5 documents)

    Export disorders for ANGPT4 gene to outside databases

    Publications
    for ANGPT4 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ANGPT4 gene, integrated from 9 sources (see all 36):
    (articles sorted by number of sources associating them with ANGPT4)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Angiopoietins 3 and 4: diverging gene counterparts in mice and humans. (PubMed id 10051567)1, 2, 3, 9 Valenzuela D.M....Yancopoulos G.D. (1999)
    2. Angiopoietin-3, a novel member of the angiopoietin family. (PubMed id 10218486)1, 2, 3 Nishimura M....Seino S. (1999)
    3. Biological characterization of angiopoietin-3 and angiopoietin-4. (PubMed id 15284220)1, 2, 9 Lee H.J....Koh G.Y. (2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
    6. Hypoxia-inducible factor-1 mediates activation of cultured vascular endothelial cells by inducing multiple angiogenic factors. (PubMed id 12958144)1, 9 Yamakawa M....Jiang C. (2003)
    7. Expression of angiopoietins in renal epithelial and clear cell carcinoma cells: regulation by hypoxia and participation in angiogenesis. (PubMed id 15198927)1, 9 Yamakawa M....Jiang C. (2004)
    8. Angiopoietin-4 inhibits angiogenesis and reduces interstitial fluid pressure. (PubMed id 16790085)1, 9 Olsen M.W....Kristjansen P.E. (2006)
    9. Assignment of ANGPT4, ANGPT1, and ANGPT2 encoding angiopoietins 4, 1 and 2 to human chromosome bands 20p13, 8q22.3-->q23 and 8p23.1, respectively, by in situ hybridization and radiation hybrid mapping. (PubMed id 10343124)1, 9 Grosios K....Jones P.F. (1999)
    10. Multiple angiopoietin recombinant proteins activate the Tie1 receptor tyrosine kinase and promote its interaction with Tie2. (PubMed id 15851516)1, 9 Saharinen P....Alitalo K. (2005)

    External Searches for ANGPT4 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing ANGPT4 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51378 HGNC: 487 AceView: ANGPT4 Ensembl:ENSG00000101280 euGenes: HUgn51378
    ECgene: ANGPT4 H-InvDB: ANGPT4

    Other Databases showing ANGPT4 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ANGPT4 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ANGPT4 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ANGPT4 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for ANGPT4 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ANGPT4 gene:
    Search GeneIP for patents involving ANGPT4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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