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Aliases for ANGPT4 Gene

Aliases for ANGPT4 Gene

  • Angiopoietin 4 2 3
  • ANG4 3 4 6
  • Angiopoietin-3 3 4
  • ANG-3 3 4
  • ANG-4 3 4
  • DJ824F16.2 (Angiopoietin 4) 3
  • Angiopoietin-4 3
  • ANG3 4
  • AGP4 3

External Ids for ANGPT4 Gene

Previous GeneCards Identifiers for ANGPT4 Gene

  • GC20M000841
  • GC20M000848
  • GC20M000801
  • GC20M000805
  • GC20M000853

Summaries for ANGPT4 Gene

Entrez Gene Summary for ANGPT4 Gene

  • Angiopoietins are proteins with important roles in vascular development and angiogenesis. All angiopoietins bind with similar affinity to an endothelial cell-specific tyrosine-protein kinase receptor. The mechanism by which they contribute to angiogenesis is thought to involve regulation of endothelial cell interactions with supporting perivascular cells. The protein encoded by this gene functions as an agonist and is an angiopoietin. [provided by RefSeq, Jul 2008]

GeneCards Summary for ANGPT4 Gene

ANGPT4 (Angiopoietin 4) is a Protein Coding gene. Among its related pathways are PI3K-Akt signaling pathway and Ras signaling pathway. GO annotations related to this gene include receptor tyrosine kinase binding and transmembrane receptor protein tyrosine kinase activator activity. An important paralog of this gene is FIBCD1.

UniProtKB/Swiss-Prot for ANGPT4 Gene

  • Binds to TEK/TIE2, modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2. Promotes endothelial cell survival, migration and angiogenesis.

Gene Wiki entry for ANGPT4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANGPT4 Gene

Genomics for ANGPT4 Gene

Regulatory Elements for ANGPT4 Gene

Genomic Location for ANGPT4 Gene

869,899 bp from pter
916,334 bp from pter
46,436 bases
Minus strand

Genomic View for ANGPT4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ANGPT4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANGPT4 Gene

Proteins for ANGPT4 Gene

  • Protein details for ANGPT4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • B4E3J9
    • Q5TFF4
    • Q9H4Z4

    Protein attributes for ANGPT4 Gene

    503 amino acids
    Molecular mass:
    56849 Da
    Quaternary structure:
    • Homodimer; disulfide-linked. Interacts with TEK/TIE2.

    Alternative splice isoforms for ANGPT4 Gene


neXtProt entry for ANGPT4 Gene

Proteomics data for ANGPT4 Gene at MOPED

Post-translational modifications for ANGPT4 Gene

  • Glycosylation at Asn96, Asn126, Asn140, Asn158, Asn247, Asn274, Asn311, Asn337, and Asn427
  • Modification sites at PhosphoSitePlus

Other Protein References for ANGPT4 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for ANGPT4 (Angiopoietin-4)

Protein Products

No data available for DME Specific Peptides for ANGPT4 Gene

Domains for ANGPT4 Gene

Gene Families for ANGPT4 Gene

  • FIBC :Fibrinogen C domain containing

Suggested Antigen Peptide Sequences for ANGPT4 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q9Y264
  • Contains 1 fibrinogen C-terminal domain.
genes like me logo Genes that share domains with ANGPT4: view

Function for ANGPT4 Gene

Molecular function for ANGPT4 Gene

GENATLAS Biochemistry: angiopoietin 4 secreted ligand for the vascular endothelial restricted receptor tyrosine kinase TEK,including phosphorylation of TEK,promoting angiogenic remodeling as well as vessel maturation and stabilization,predominantly expressed in lung
UniProtKB/Swiss-Prot Function: Binds to TEK/TIE2, modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2. Promotes endothelial cell survival, migration and angiogenesis.

Gene Ontology (GO) - Molecular Function for ANGPT4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030297 transmembrane receptor protein tyrosine kinase activator activity IDA 10051567
GO:0030971 receptor tyrosine kinase binding IDA 10051567
genes like me logo Genes that share ontologies with ANGPT4: view
genes like me logo Genes that share phenotypes with ANGPT4: view

Animal Model Products

CRISPR Products

miRNA for ANGPT4 Gene

miRTarBase miRNAs that target ANGPT4

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ANGPT4 Gene

Localization for ANGPT4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ANGPT4 Gene


Subcellular locations from

Jensen Localization Image for ANGPT4 Gene COMPARTMENTS Subcellular localization image for ANGPT4 gene
Compartment Confidence
extracellular 5
nucleus 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for ANGPT4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 10025962
genes like me logo Genes that share ontologies with ANGPT4: view

Pathways for ANGPT4 Gene

genes like me logo Genes that share pathways with ANGPT4: view

Pathways by source for ANGPT4 Gene

Gene Ontology (GO) - Biological Process for ANGPT4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IEA --
GO:0001935 NOT endothelial cell proliferation IDA 10025962
GO:0007171 activation of transmembrane receptor protein tyrosine kinase activity IDA 10051567
GO:0007596 blood coagulation TAS --
GO:0010595 positive regulation of endothelial cell migration IDA 12958144
genes like me logo Genes that share ontologies with ANGPT4: view

Compounds for ANGPT4 Gene

(2) Novoseek inferred chemical compound relationships for ANGPT4 Gene

Compound -log(P) Hits PubMed IDs
vegf 55.5 3
tyrosine 35.9 2
genes like me logo Genes that share compounds with ANGPT4: view

Transcripts for ANGPT4 Gene

mRNA/cDNA for ANGPT4 Gene

(8) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ANGPT4 Gene

Angiopoietin 4:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ANGPT4

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for ANGPT4

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ANGPT4 Gene

No ASD Table

Relevant External Links for ANGPT4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ANGPT4 Gene

mRNA expression in normal human tissues for ANGPT4 Gene

mRNA differential expression in normal tissues according to GTEx for ANGPT4 Gene

This gene is overexpressed in Adipose - Subcutaneous (5.8), Adipose - Visceral (Omentum) (5.1), Breast - Mammary Tissue (4.3), and Cervix - Endocervix (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ANGPT4 Gene

SOURCE GeneReport for Unigene cluster for ANGPT4 Gene Hs.278973

mRNA Expression by UniProt/SwissProt for ANGPT4 Gene

Tissue specificity: Highly expressed in the lung with much lower levels found in other tissues
genes like me logo Genes that share expressions with ANGPT4: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for ANGPT4 Gene

Orthologs for ANGPT4 Gene

This gene was present in the common ancestor of animals.

Orthologs for ANGPT4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ANGPT4 35
  • 97.36 (n)
  • 96.15 (a)
  • 99 (a)
(Bos Taurus)
Mammalia ANGPT4 35
  • 80.99 (n)
  • 68.88 (a)
  • 68 (a)
(Canis familiaris)
Mammalia ANGPT4 35
  • 81.12 (n)
  • 69.88 (a)
  • 69 (a)
(Mus musculus)
Mammalia Angpt4 35
  • 70.82 (n)
  • 56.14 (a)
Angpt4 16
Angpt4 36
  • 54 (a)
(Monodelphis domestica)
Mammalia ANGPT4 36
  • 59 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 24 (a)
(Rattus norvegicus)
Mammalia Angpt4 35
  • 71.7 (n)
  • 56.54 (a)
(Gallus gallus)
Aves ANGPT4 35
  • 68.53 (n)
  • 55.28 (a)
  • 52 (a)
(Anolis carolinensis)
Reptilia ANGPT4 36
  • 55 (a)
(Danio rerio)
Actinopterygii angpt4 36
  • 44 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10359 37
  • 38 (a)
sca 37
  • 27 (a)
CG9500 37
  • 38 (a)
Species with no ortholog for ANGPT4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ANGPT4 Gene

Gene Tree for ANGPT4 (if available)
Gene Tree for ANGPT4 (if available)

Paralogs for ANGPT4 Gene

Selected SIMAP similar genes for ANGPT4 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ANGPT4: view

Variants for ANGPT4 Gene

Sequence variations from dbSNP and Humsavar for ANGPT4 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs478451 -- 915,369(+) ctcac(A/G)gtcaa intron-variant
rs487473 -- 909,226(+) AAGTG(C/T)CTGGC intron-variant
rs502522 -- 915,656(+) GTCCG(C/T)TCAGC intron-variant
rs509769 -- 916,419(+) CTCCG(C/G)CCCCA upstream-variant-2KB
rs509880 -- 916,452(+) TCTTC(A/C)CTCCT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ANGPT4 Gene

Variant ID Type Subtype PubMed ID
nsv912580 CNV Gain 21882294
nsv510778 CNV Loss 20534489
nsv458848 CNV Loss 19166990
nsv912582 CNV Loss 21882294
nsv912583 CNV Loss 21882294
esv274947 CNV Gain+Loss 21479260
nsv817879 CNV Gain 17921354
nsv912584 CNV Loss 21882294

Relevant External Links for ANGPT4 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANGPT4 Gene

Disorders for ANGPT4 Gene

(5) Novoseek inferred disease relationships for ANGPT4 Gene

Disease -log(P) Hits PubMed IDs
carcinoma renal cell 27.3 1
metastasis 6.37 1
breast cancer 0 2
tumors 0 3
cancer 0 2

Relevant External Links for ANGPT4

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with ANGPT4: view

No data available for UniProtKB/Swiss-Prot for ANGPT4 Gene

Publications for ANGPT4 Gene

  1. Angiopoietins 3 and 4: diverging gene counterparts in mice and humans. (PMID: 10051567) Valenzuela D.M. … Yancopoulos G.D. (Proc. Natl. Acad. Sci. U.S.A. 1999) 2 3 4 23
  2. Biological characterization of angiopoietin-3 and angiopoietin-4. (PMID: 15284220) Lee H.J. … Koh G.Y. (FASEB J. 2004) 3 4 23
  3. Angiopoietin-3, a novel member of the angiopoietin family. (PMID: 10218486) Nishimura M. … Seino S. (FEBS Lett. 1999) 2 3 4
  4. Multiple angiopoietin recombinant proteins activate the Tie1 receptor tyrosine kinase and promote its interaction with Tie2. (PMID: 15851516) Saharinen P. … Alitalo K. (J. Cell Biol. 2005) 3 23
  5. Angiopoietin-4 inhibits angiogenesis and reduces interstitial fluid pressure. (PMID: 16790085) Olsen M.W. … Kristjansen P.E. (Neoplasia 2006) 3 23

Products for ANGPT4 Gene

Sources for ANGPT4 Gene

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