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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ANGPT2 Gene

protein-coding GIFtS: 68
GCID: GC08M006347

angiopoietin 2

Explore 135 diseases affiliated with
ANGPT2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Angiopoietin 2¹ ²		Tie2-Ligand¹
ANG-2² ³		Angiopoietin-2¹
ANG2² ⁵		Angiopoietin-2B¹
Ang2¹		Angiopoietin-2a¹
AGPT2²

External Ids:	HGNC: 485¹	Entrez Gene: 285²	Ensembl: ENSG00000091879⁷	OMIM: 601922⁵	UniProtKB: O15123³

Export aliases for ANGPT2 gene to outside databases

Previous GC identifers: GC08M006424 GC08M006614 GC08M006139

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ANGPT2:

The protein encoded by this gene is an antagonist of angiopoietin 1 (ANGPT1) and endothelial TEK tyrosine kinase

(TIE-2, TEK). The encoded protein disrupts the vascular remodeling ability of ANGPT1 and may induce endothelial cell

apoptosis. Three transcript variants encoding three different isoforms have been found for this gene. (provided by

RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: ANGP2_HUMAN, O15123

Function: Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce

tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF,

ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular

regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a

permissive angiogenic signal

Gene Wiki entry for ANGPT2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000008.10 NC_018919.1 NT_023736.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ANGPT2 gene promoter:
AhR AML1a GATA-6 FOXO1a STAT5A Arnt YY1 FOXO1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ANGPT2 promoter sequence

Search SABiosciences Chromatin IP Primers for ANGPT2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ANGPT2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p23.1 Ensembl cytogenetic band: 8p23.1 HGNC cytogenetic band: 8p23

ANGPT2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ANGPT2 gene location

GeneLoc information about chromosome 8 GeneLoc Exon Structure

GeneLoc location for GC08M006347: view genomic region (about GC identifiers)

Start:	6,357,172 bp from pter	End:	6,420,930 bp from pter
Size:	63,759 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ANGP2_HUMAN, O15123 (See protein sequence)

Recommended Name: Angiopoietin-2 precursor

Size: 496 amino acids; 56919 Da

Subunit: Interacts with TEK/TIE2, competing for the same binding site as ANGPT1

Subcellular location: Secreted

3 PDB 3D structures from and Proteopedia for ANGPT2:

1Z3S (3D)

1Z3U (3D)

2GY7 (3D)

Secondary accessions: A0AV38 A8K205 B7ZLM7 Q9NRR7 Q9P2Y7

Alternative splicing: 3 isoforms: O15123-1 O15123-2 O15123-3 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ANGPT2: NX_O15123

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O15123

ANGPT2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_001112359.1 NP_001112360.1 NP_001138.1

ENSEMBL proteins:

ENSP00000314897 ENSP00000343517 ENSP00000428023 ENSP00000400782

Reactome Protein details: O15123
Human Recombinant Protein Products:

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	Sino Biological Recombinant Protein for ANGPT2
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for ANGPT2

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	--
GO:0005615	extracellular space	IDA	9660821
GO:0005634	nucleus	IEA	--
GO:0005886	plasma membrane	IEA	--
GO:0042995	cell projection	IEA	--

ANGPT2 for ontologies About GeneDecksing

ANGPT2 Antibody Products:

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	ThermoFisher Antibody for ANGPT2

Assay Products for ANGPT2:

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	GenScript Custom Assay Services for ANGPT2
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for ANGPT2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ANGPT2 for domains About GeneDecksing

4 InterPro domains/families:

IPR020837 Fibrinogen_CS

IPR014715 Fibrinogen_a/b/g_C_2

IPR002181 Fibrinogen_a/b/g_C_dom

IPR014716 Fibrinogen_a/b/g_C_1

Graphical View of Domain Structure for InterPro Entry O15123

ProtoNet protein and cluster: O15123

1 Blocks protein family: IPB002181 Fibrinogen

UniProtKB/Swiss-Prot: ANGP2_HUMAN, O15123

Domain: The Fibrinogen C-terminal domain mediates interaction with the TEK/TIE2 receptor

Similarity: Contains 1 fibrinogen C-terminal domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: ANGP2_HUMAN, O15123

Function: Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce

tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF,

ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular

regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a

permissive angiogenic signal

Genatlas biochemistry entry for ANGPT2:

angiopoietin 1,75kDa,secreted ligand,for the vascular endothelial restricted receptor tyrosine kinase TEK,including

phosphorylation of TEK,expressed only at sites of vascular remodeling in adult,antagonizing ANGPT1 by blocking its

ability to activate its ligand

Summary:

During embryonic development, ANGPT2 as signaling molecule is secreted from the following cells: Angioblasts in Proepicardium It affects the following cells: Mural Cells in Splanchnic Mesoderm

miRNA Products:		OriGene 3'-UTR Clone (see all 3): ANGPT2 Browse MicroRNA Expression Plasmids
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		8/26 QIAGEN miScript miRNA Assays for microRNAs that regulate ANGPT2 (see all 26):
		hsa-miR-125a-5p hsa-miR-539 hsa-miR-3616-5p hsa-miR-944 hsa-miR-507 hsa-miR-125b hsa-miR-542-3p hsa-miR-205*

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Gene Editing
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANGPT2

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005102	receptor binding	TAS	10766762
GO:0005515	protein binding	IPI	--
GO:0030971	receptor tyrosine kinase binding	IPI	19922791
GO:0046872	metal ion binding	IEA	--

ANGPT2 for ontologies About GeneDecksing

Animal Models:
7 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Angpt2):

cardiovascular system	digestive/alimentary	homeostasis/metabolism	immune system	integument
mortality/aging	vision/eye

ANGPT2 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/11 super-pathways (see all 11) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

PEDF Induced Signaling

8/11 pathways (see all 11)
PEDF Induced Signaling	1.00	STAT3 Pathway	0.47
MIF Mediated Glucocorticoid Regulation	0.73	Endothelin-1 Signaling Pathway	0.44
MIF Regulation of Innate Immune Cells	0.71	NFAT Signaling and Lymphocyte Interactions	0.37
IL-6 Pathway	0.61	PGC1Alpha Pathway	0.33

TGF-Beta Pathway

TGF-Beta Pathway	1.00	JNK Pathway	0.50
MAPK Family Pathway	0.60	Regulation of eIF4 and p70S6K	0.43
JAK-STAT Pathway	0.57	SOCS Pathway	0.29

Development_PDGF signaling via STATs and NF-kB

	Development_Angiopoietin - Tie2 signaling	0.38			Angiopoietin-TIE2 Signaling	0.13
	Development Angiopoietin - Tie2 signaling	0.38			Angiopoietin receptor Tie2-mediated signaling	0.11

Akt Signaling

	Akt Signaling	1.00			Tec Kinases Signaling	0.55
	p38 Signaling	0.60

Rho Family GTPases

	Rho Family GTPases	1.00			Molecular Mechanisms of Cancer	0.51
	ERK Signaling	0.61

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for ANGPT2

Development Angiopoietin - Tie2 signaling

5/26 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for ANGPT2 (see all 26)

	Endothelin-1 Signaling Pathway
	Molecular Mechanisms of Cancer
	Antioxidant Action of Vitamin-C
	NFAT Signaling and Lymphocyte Interactions
	JNK Pathway

2 Cell Signaling Technology (CST) Pathways for ANGPT2

	Angiogenesis
	Tyrosine Kinases / Adaptors

1 GeneGo (Thomson Reuters) Pathway for ANGPT2

Development Angiopoietin - Tie2 signaling

1 BioSystems Pathway for ANGPT2

Angiopoietin receptor Tie2-mediated signaling

3 Reactome Pathways for ANGPT2

	Hemostasis
	Cell surface interactions at the vascular wall
	Tie2 Signaling

ANGPT2 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for ANGPT2

STRING Interaction Network Preview (showing 5 interactants - click image to see 16)

5/18 Interacting proteins for ANGPT2 (O15123^{1, 2, 3} ENSP00000314897⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 18)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
TEK	Q02763¹^,³, ENSP00000383977⁴	EBI-2912111,EBI-2257090 I2D: score=4 STRING: ENSP00000383977
ANXA7	P20073²^,³	MINT-8247976 I2D: score=2
CSNK2B	P67870²^,³	MINT-8253011 I2D: score=2
CDKN1A	P38936²^,³, ENSP00000244741⁴	MINT-8251562 I2D: score=2 STRING: ENSP00000244741
ANGPT1	Q15389³, ENSP00000297450⁴	I2D: score=1 STRING: ENSP00000297450

About this table

Gene Ontology (GO): 5/23 biological process terms (GO ID links to tree view) (see all 23): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001525	angiogenesis	IEA	--
GO:0001666	response to hypoxia	IEA	--
GO:0007165	signal transduction	TAS	10766762
GO:0007281	germ cell development	IEA	--
GO:0007596	blood coagulation	TAS	--

ANGPT2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

ANGPT2 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ANGPT2
10/34 Novoseek chemical compound relationships for ANGPT2 gene (see all 34) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
vegf	88.9	779	15548809 (9), 12808060 (8), 15871447 (7), 16538528 (7) (see all 99)
p00055	55.7	2	16179272 (1), 15112366 (1)
tyrosine	55.5	62	19223473 (2), 11397875 (1), 15743796 (1), 19390459 (1) (see all 44)
matrigel	39.7	3	19616847 (2)
progestin	17.4	2	10587365 (1), 12213726 (1)
ribonucleic acid	16.4	2	11095472 (1), 11297624 (1)
methylglyoxal	11.1	2	16413606 (1), 17387784 (1)
trastuzumab	7.37	5	10922985 (2), 11490375 (1), 17308086 (1)
wortmannin	7.08	6	16447257 (1), 17215522 (1), 11002428 (1), 16826573 (1)
celecoxib	6.62	6	16338068 (3), 16613672 (1), 17401377 (1)

Search CenterWatch for drugs/clinical trials and news about ANGPT2 / ANGP2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ANGPT2 gene (3 alternative transcripts):

NM_001118887.1 NM_001118888.1 NM_001147.2

Unigene Cluster for ANGPT2:

Angiopoietin 2

Hs.583870 [show with all ESTs]

Unigene Representative Sequence: NM_001147

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000325203(uc003wqj.4 uc003wqk.4 uc010lri.3) ENST00000338312

ENST00000523120(uc003wql.4) ENST00000415216

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		8/26 QIAGEN miScript miRNA Assays for microRNAs that regulate ANGPT2 (see all 26):
		hsa-miR-125a-5p hsa-miR-539 hsa-miR-3616-5p hsa-miR-944 hsa-miR-507 hsa-miR-125b hsa-miR-542-3p hsa-miR-205*

		SwitchGear 3'UTR luciferase reporter plasmid: ANGPT2 3' UTR sequence

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ANGPT2

Additional cDNA sequence:

AB009865.1 AF004327.1 AF187858.1 AF218015.1 AJ289780.1 AJ289781.1 AK075219.1 AK225698.1

AK290070.1 AK310171.1 AK312541.1 BC022490.1 BC126200.1 BC126202.1 BC143902.1

11 DOTS entries:

DT.100713589 DT.87017755 DT.92470304 DT.121490400 DT.40114945 DT.207882 DT.211113 DT.40114946

DT.121490371 DT.121490552 DT.40268010

24/66 AceView cDNA sequences (see all 66):

BQ010977 CR620685 BI966762 AI825611 AA252124 CK903581 AA242791 AL573084

CK903582 CB047127 BC022490 AA125872 BG212051 AF218015 BX391728 BF062790

AW105203 BI962885 BQ004033 AI347555 BX504641 AJ289781 CF529257 AL548548

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ANGPT2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTGGCTGGCA

About this image

ANGPT2 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

10 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Lateral Plate Mesoderm

Proepicardium

Angioblasts

Selective marker (cell-identifying gene)

Endothelium

Extraembryonic Mesoderm

Extraembryonic Mural Cells

Extraembryonic Tissues

Lateral Plate Mesoderm

Splanchnic Mesoderm

Mural Cells

Pericytes, Smooth Muscle

Lymph

Lymphatic Vessels

Lymphatic Endothelial Cells

Endothelium

Placenta

Chorionic Villus

Villous Cytotrophoblast Cells

Extraembryonic Tissues, Placenta

Placenta

Extravillous Cytotrophoblast Layer

Extravillous Cytotrophoblast Cells

Extraembryonic Tissues, Placenta

Eye

Inner Nuclear Layer

Mature Horizontal Cells

Horizontal, Retina

Ovary

Ovary

Limb

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 10/13 LifeMap Cells (see all 13)

Name

Category

PureStem™ endothelial progenitor 30-MV2-12 (Embryonic Progenitor Cell)

Blood, Endothelium

PureStem™ endothelial Progenitor 30-SM2-3 (Embryonic Progenitor Cell)

Blood, Endothelium

PureStem™ endothelial progenitor 30-MV2-14 (Embryonic Progenitor Cell)

Endothelium

PureStem™ endothelial progenitor 30-SM2-1 (Embryonic Progenitor Cell)

Endothelium

PureStem™ endothelial progenitor RP1-MV2-18 (Embryonic Progenitor Cell)

Endothelium

PureStem™ progenitor W8 (Embryonic Progenitor Cell)

Posterior foregut-like cells (A scalable, suspensi...)

Podocalyxin+, CD24+, GCTM2- (Derivation and sorti...)

Mesendoderm (Derivation and sorti...)

Podocalyxin+, CD24+, GCTM2 (low) (Derivation and sorti...)

See ANGPT2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ANGPT2

SOURCE GeneReport for Unigene cluster: Hs.583870

SABiosciences Expression via Pathway-Focused PCR Arrays including ANGPT2:

Angiogenic Growth Factors in human mouse rat

Cancer PathwayFinder in human mouse rat

Liver Cancer in human mouse rat

Angiogenesis in human mouse rat

Adipogenesis in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANGPT2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for ANGPT2 gene from 4/14 species (see all 14) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	ANGPT2¹	angiopoietin 2	81.72(n) 85.86(a)		395610 NM_204817.1 NP_990148.1
lizard (Anolis carolinensis)	Reptilia	ANGPT2⁶	--	81(a)	1 ↔ 1	1(152033959-152100425)
zebrafish (Danio rerio)	Actinopterygii	angpt2b¹	angiopoietin 2b	59.29(n) 54.88(a)		114408 NM_131814.1 NP_571889.1
fruit fly (Drosophila melanogaster)	Insecta	CG9593⁶	--	23(a)	1 → many	3R(11627997-11629375)

ENSEMBL Gene Tree for ANGPT2 (if available)
TreeFam Gene Tree for ANGPT2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ANGPT2 gene

FGL2² ANGPT4² FGA² FGG² ANGPTL6² ANGPTL2² ANGPTL4² ANGPT1²

ANGPTL3² ANGPTL1² ANGPTL7² FGB² FGL1²

14 SIMAP similar genes for ANGPT2 using alignment to 2 protein entries: ANGP2_HUMAN (see all proteins):

angiopoietin-2 ANGPT1 AngA FIBCD1 ANGPT4 FCN3

FCN1 MFAP4 ANGPTL7 FGL1 FCN2 ANGPTL2

FGL2 ANGPTL1

ANGPT2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 8 pos	Sequence	#	AA Chg	Type	More	#	Pop	Total sample
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs116778566^1,2	C,F,	--	6138939(+)	`AAAGGG/TATTGC`	1	--	int¹		1	WA	118
rs78662277^1,2	F,	--	6139181(+)	`CTTTTT/CATTAA`	1	--	int¹		1	WA	118
rs2442474^1,2	C,O,	--	6139197(-)	`ATAAAT/CGTTAT`	1	--	int¹		5	NA	146
rs3929194^1,2	H	--	6139362(-)	`AGCACC/TTGCAA`	1	--	spa¹		4	NS EA	420
rs2515597^1,2	C,F,O,H,	--	6139629(+)	`GACCAT/CTGTGC`	1	--	int¹ ese³		11	NS EA NA CSA WA	800
rs2442473^1,2	C,F,O,H,	--	6140283(-)	`CTTCAA/GTTCCT`	1	--	int¹		23	NS EA NA CSA WA	2452
rs58788193^1,2	F,	--	6140442(+)	`CATTAG/ACGTTT`	1	--	int¹		1	EA	120
rs73664539^1,2	C,	--	6140839(+)	`AAGGTG/AAAGAC`	1	--	int¹		2	WA	120
rs111802946^1,2	C,	--	6140976(+)	`TACTAT/CGAAAA`	1	--	int¹		2	NA WA	120
rs2442470^1,2	C,	--	6141116(-)	`TGCACC/TCCAGC`	1	--	int¹ ese³		1	NA	2

HapMap Linkage Disequilibrium report for ANGPT2 (6357172 - 6420930 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for ANGPT2
2 CNVs: 5250 39519
Human Gene Mutation Database (HGMD): ANGPT2

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ANGPT2 for disorders           About GeneDecksing

OMIM gene information: 601922    OMIM disorders: --

20/135 diseases for ANGPT2 (see all 135):    About MalaCards

macular holes placenta accreta proliferative diabetic retinopathy placental insufficiency

adult respiratory distress syndrome non-small cell lung carcinoma critical limb ischemia diabetic retinopathy

hereditary hemorrhagic telangiectasia acute myocardial infarction uterine carcinosarcoma non-hodgkin lymphoma

squamous cell carcinoma soft tissue sarcoma myocardial infarction severe combined immunodeficiency

congestive heart failure sickle cell disease arteriovenous malformation gastrointestinal stromal tumor

3 diseases from the University of Copenhagen DISEASES database for ANGPT2:

Cancer Diabetic retinopathy Vascular disease

10/88 Novoseek disease relationships for ANGPT2 gene (see all 88) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
neovascularization	74.1	34	9710115 (4), 9808608 (1), 15389527 (1), 16100571 (1) (see all 24)
tumors	56.2	347	17440098 (8), 20197469 (6), 14767538 (6), 19815705 (5) (see all 99)
metastasis	46.7	60	17483337 (5), 19408052 (2), 20359117 (2), 18727515 (2) (see all 31)
proliferative diabetic retinopathy	42.6	6	15767056 (3), 15548809 (1)
diabetic retinopathy	37.5	8	15548809 (3), 19238311 (2), 19304585 (1), 17200776 (1)
inflammation	37.4	38	19390459 (4), 10944458 (2), 16685017 (2), 18930996 (2) (see all 18)
glioblastoma multiforme	34.4	1	18991494 (1)
preeclampsia	34	21	19875484 (5), 17409768 (2), 16182107 (2), 19478794 (2) (see all 7)
glioma	33.8	46	15743799 (7), 11507079 (6), 16424009 (4), 12861074 (4) (see all 11)
cancer	32.7	64	19216842 (4), 15196437 (4), 10922985 (3), 16614513 (2) (see all 26)

Genetic Association Database (GAD): ANGPT2
Human Genome Epidemiology (HuGE) Navigator: ANGPT2 (16 documents)

Export disorders for ANGPT2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ANGPT2 gene, integrated from 9 sources (see all 645):
(articles sorted by number of sources associating them with ANGPT2)

Utopia: connect your pdf to the dynamic
world of online information

Angiopoietin 2 is a partial agonist/antagonist of Tie2 signaling in the endothelium. (PubMed id 19223473)^{1, 2, 9} Yuan H.T....Parikh S.M. (2009)
Characterization and expression of a novel alternatively spliced human angiopoietin-2. (PubMed id 10766762)^{1, 2, 9} Kim I.... Koh G.Y. (2000)
Biologic significance of angiopoietin-2 expression in human hepatocellular carcinoma. (PubMed id 9927494)^{1, 2, 9} Tanaka S....Wands J.R. (1999)
Biological characterization of angiopoietin-3 and angiopoietin-4. (PubMed id 15284220)^{1, 2, 9} Lee H.J....Koh G.Y. (2004)
An Angiopoietin-2 gene polymorphism in unexplained intrauterine fetal death: a multi-center study. (PubMed id 15694966)^{1, 4} Huber A....Hefler L. (2005)
Structure of the angiopoietin-2 receptor binding domain and identification of surfaces involved in Tie2 recognition. (PubMed id 15893672)^{1, 2} Barton W.A....Nikolov D.B. (2005)
Polymorphism of the p53 tumor suppressor gene is associated with susceptibility to uterine leiomyoma. (PubMed id 16009172)^{1, 4} Denschlag D....Pietrowski D. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Angiopoietin-1 and angiopoietin-2 share the same binding domains in the Tie-2 receptor involving the first Ig-like loop and the epidermal growth factor-like repeats. (PubMed id 12427764)^{1, 2} Fiedler U....Augustin H.G. (2003)
Angiopoietin-2 polymorphism in women with idiopathic recurrent miscarriage. (PubMed id 14556828)^{1, 4} Pietrowski D....Keck C. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 285	HGNC: 485	AceView: ANGPT2	Ensembl:ENSG00000091879	euGenes: HUgn285
ECgene: ANGPT2	H-InvDB: ANGPT2

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ANGPT2	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for ANGPT2	Genetics and Cytogenetics in Oncology and Haematology
Wikipedia	http://en.wikipedia.org/wiki/Angiopoietin

Intellectual Property for ANGPT2 gene
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Patent Information for ANGPT2 gene:
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