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ANGPT2 Gene

protein-coding   GIFtS: 65
GCID: GC08M006347

Angiopoietin 2

  See ANGPT2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Angiopoietin 21 2     Tie2-ligand2
ANG-22 3     angiopoietin-22
ANG22 5     angiopoietin-2B2
AGPT22     angiopoietin-2a2

External Ids:    HGNC: 4851   Entrez Gene: 2852   Ensembl: ENSG000000918797   OMIM: 6019225   UniProtKB: O151233   

Export aliases for ANGPT2 gene to outside databases

Previous GC identifers: GC08M006424 GC08M006614 GC08M006139


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ANGPT2 Gene:
The protein encoded by this gene is an antagonist of angiopoietin 1 (ANGPT1) and endothelial TEK tyrosine kinase
(TIE-2, TEK). The encoded protein disrupts the vascular remodeling ability of ANGPT1 and may induce endothelial
cell apoptosis. Three transcript variants encoding three different isoforms have been found for this gene.
(provided by RefSeq, Jul 2008)

GeneCards Summary for ANGPT2 Gene:
ANGPT2 (angiopoietin 2) is a protein-coding gene. Diseases associated with ANGPT2 include chorioangioma, and twin-to-twin transfusion syndrome. GO annotations related to this gene include receptor tyrosine kinase binding and receptor binding. An important paralog of this gene is FGL2.

UniProtKB/Swiss-Prot: ANGP2_HUMAN, O15123
Function: Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce
tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as
VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent
vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus
serving as a permissive angiogenic signal

Gene Wiki entry for ANGPT2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000008.10  NC_018919.2  NT_023736.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the ANGPT2 gene promoter:
         AhR   AML1a   GATA-6   FOXO1a   STAT5A   Arnt   YY1   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidANGPT2 promoter sequence
   Search Chromatin IP Primers for ANGPT2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ANGPT2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p23.1   Ensembl cytogenetic band:  8p23.1   HGNC cytogenetic band: 8p23

ANGPT2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ANGPT2 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M006347:  view genomic region     (about GC identifiers)

Start:
6,357,172 bp from pter      End:
6,420,930 bp from pter
Size:
63,759 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ANGP2_HUMAN, O15123 (See protein sequence)
Recommended Name: Angiopoietin-2 precursor  
Size: 496 amino acids; 56919 Da
Subunit: Interacts with TEK/TIE2, competing for the same binding site as ANGPT1
4 PDB 3D structures from and Proteopedia for ANGPT2:
1Z3S (3D)        1Z3U (3D)        2GY7 (3D)        4JZC (3D)    
Secondary accessions: A0AV38 A8K205 B7ZLM7 Q9NRR7 Q9P2Y7
Alternative splicing: 3 isoforms:  O15123-1   O15123-2   O15123-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ANGPT2: NX_O15123

Explore proteomics data for ANGPT2 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn89, Asn119, Asn133, Asn151, Asn240, Asn304
  • Modification sites at PhosphoSitePlus

  • See ANGPT2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001112359.1  NP_001112360.1  NP_001138.1  

    ENSEMBL proteins: 
     ENSP00000314897   ENSP00000343517   ENSP00000428023   ENSP00000400782  
    Reactome Protein details: O15123

    ANGPT2 Human Recombinant Protein Products:

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    Sino Biological Recombinant Protein for ANGPT2
    Sino Biological Cell Lysate for ANGPT2
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    Cloud-Clone Corp. Proteins for ANGPT2

     
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    antibodies-online proteins for ANGPT2 (31 products) 

     
    antibodies-online peptides for ANGPT2

    ANGPT2 Antibody Products:

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    antibodies-online antibodies for ANGPT2 (66 products) 

    ANGPT2 Assay Products:

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    Search eBioscience for ELISAs for ANGPT2 
    antibodies-online kits for ANGPT2 (56 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    FIBC: Fibrinogen C domain containing

    5 InterPro protein domains:
     IPR014715 Fibrinogen_a/b/g_C_2
     IPR028844 Ang-2
     IPR014716 Fibrinogen_a/b/g_C_1
     IPR020837 Fibrinogen_CS
     IPR002181 Fibrinogen_a/b/g_C_dom

    Graphical View of Domain Structure for InterPro Entry O15123

    ProtoNet protein and cluster: O15123

    1 Blocks protein domain: IPB002181 Fibrinogen

    UniProtKB/Swiss-Prot: ANGP2_HUMAN, O15123
    Domain: The Fibrinogen C-terminal domain mediates interaction with the TEK/TIE2 receptor
    Similarity: Contains 1 fibrinogen C-terminal domain


    Find genes that share domains with ANGPT2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ANGP2_HUMAN, O15123
    Function: Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce
    tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as
    VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent
    vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus
    serving as a permissive angiogenic signal

         Genatlas biochemistry entry for ANGPT2:
    angiopoietin 1,75kDa,secreted ligand,for the vascular endothelial restricted receptor tyrosine kinase
    TEK,including phosphorylation of TEK,expressed only at sites of vascular remodeling in adult,antagonizing ANGPT1
    by blocking its ability to activate its ligand

         Summary: 
    During embryonic development, ANGPT2 as signaling molecule is secreted from the following cells:
                
    Lateral Plate Mesoderm: Angioblasts (Proepicardium)

    It affects the following cells:
    Lateral Plate Mesoderm: Mural Cells (Splanchnic Mesoderm)

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding TAS10766762
    GO:0005515protein binding IPI--
    GO:0030971receptor tyrosine kinase binding IPI19922791
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with ANGPT2           About GenesLikeMe


    Phenotypes:
         8 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Angpt2):
     cardiovascular system  digestive/alimentary  homeostasis/metabolism  immune system  integument 
     mortality/aging  respiratory system  vision/eye 

    Find genes that share phenotypes with ANGPT2           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for ANGPT2

    miRNA
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    Block miRNA regulation of human, mouse, rat ANGPT2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ANGPT2 (see all 26):
    hsa-miR-125a-5p hsa-miR-539 hsa-miR-3616-5p hsa-miR-944 hsa-miR-507 hsa-miR-125b hsa-miR-542-3p hsa-miR-205*
    SwitchGear 3'UTR luciferase reporter plasmidANGPT2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ANGPT2

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 3): ANGPT2 (NM_001147)
    Sino Biological Human cDNA Clone for ANGPT2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ANGPT2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ANGPT2

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    Flow Cytometry
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    eBioscience FlowRNA Probe Sets ( VA1-14248) for ANGPT2 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ANGP2_HUMAN, O15123: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    nucleus2
    plasma membrane2
    cytoskeleton1
    endoplasmic reticulum1
    lysosome1
    mitochondrion1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IDA9660821
    GO:0005634nucleus IEA--
    GO:0005886plasma membrane IEA--
    GO:0042995cell projection IEA--

    Find genes that share ontologies with ANGPT2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ANGPT2 About   (see all 13)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Immune response IL 23 signaling pathway
    Development Angiopoietin Tie2 signaling0.38
    Angiopoietin receptor Tie2-mediated signaling0.32
    Angiopoietin-TIE2 Signaling0.36
    2PEDF Induced Signaling
    MIF Regulation of Innate Immune Cells0.94
    NFAT Signaling and Lymphocyte Interactions0.57
    MIF Mediated Glucocorticoid Regulation0.94
    PGC1Alpha Pathway0.51
    PEDF Induced Signaling0.73
    STAT3 Pathway0.47
    all-trans-Retinoic Acid Signaling in Brain0.71
    Endothelin-1 Signaling Pathway0.46
    3TGF-Beta Pathway
    TGF-Beta Pathway0.60
    JNK Pathway0.51
    MAPK Family Pathway0.60
    Regulation of eIF4 and p70S6K0.43
    JAK-STAT Pathway0.57
    SOCS Pathway0.40
    4Akt Signaling
    Akt Signaling0.60
    Tec Kinases Signaling0.55
    p38 Signaling0.60
    5ERK Signaling
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61


    Find genes that share SuperPaths with ANGPT2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for ANGPT2 (see all 26)
        Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    NFAT Signaling and Lymphocyte Interactions
    JNK Pathway

    2 Cell Signaling Technology (CST) Pathways for ANGPT2
        Angiogenesis
    Tyrosine Kinases / Adaptors

    1 GeneGo (Thomson Reuters) Pathway for ANGPT2
        Development Angiopoietin - Tie2 signaling

    1 BioSystems Pathway for ANGPT2
        Angiopoietin receptor Tie2-mediated signaling


    1 Reactome Pathway for ANGPT2
        Tie2 Signaling


    4 Kegg Pathways  (Kegg details for ANGPT2):
        Ras signaling pathway
    Rap1 signaling pathway
    HIF-1 signaling pathway
    PI3K-Akt signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ANGPT2: 
              Angiogenic Growth Factors in human mouse rat
              Cancer PathwayFinder in human mouse rat
              Liver Cancer in human mouse rat
              Angiogenesis in human mouse rat
              Adipogenesis in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for ANGPT2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 16)

    Selected Interacting proteins for ANGPT2 (O151231, 2, 3 ENSP000003148974) via UniProtKB, MINT, STRING, and/or I2D (see all 24)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CSNK2BP678702, 3MINT-8253011 I2D: score=2 
    ENSG00000206406P678702, 3MINT-8253011 I2D: score=2 
    ENSG00000224398P678702, 3MINT-8253011 I2D: score=2 
    ENSG00000224774P678702, 3MINT-8253011 I2D: score=2 
    ENSG00000228875P678702, 3MINT-8253011 I2D: score=2 
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    Gene Ontology (GO): Selected biological process terms (see all 22):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis IEA--
    GO:0001666response to hypoxia IEA--
    GO:0007165signal transduction TAS10766762
    GO:0007281germ cell development IEA--
    GO:0007596blood coagulation TAS--

    Find genes that share ontologies with ANGPT2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ANGPT2 (ANGP2)

    Selected Novoseek inferred chemical compound relationships for ANGPT2 gene (see all 34)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    vegf 88.9 779 15548809 (9), 12808060 (8), 15871447 (7), 16538528 (7) (see all 99)
    p00055 55.7 2 16179272 (1), 15112366 (1)
    tyrosine 55.5 62 19223473 (2), 11397875 (1), 15743796 (1), 19390459 (1) (see all 44)
    matrigel 39.7 3 19616847 (2)
    progestin 17.4 2 10587365 (1), 12213726 (1)
    ribonucleic acid 16.4 2 11095472 (1), 11297624 (1)
    methylglyoxal 11.1 2 16413606 (1), 17387784 (1)
    trastuzumab 7.37 5 10922985 (2), 11490375 (1), 17308086 (1)
    wortmannin 7.08 6 16447257 (1), 17215522 (1), 11002428 (1), 16826573 (1)
    celecoxib 6.62 6 16338068 (3), 16613672 (1), 17401377 (1)



    Find genes that share compounds with ANGPT2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ANGPT2 gene (3 alternative transcripts): 
    NM_001118887.1  NM_001118888.1  NM_001147.2  

    Unigene Cluster for ANGPT2:

    Angiopoietin 2
    Hs.583870  [show with all ESTs]
    Unigene Representative Sequence: NM_001147
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000325203(uc003wqj.4 uc003wqk.4 uc010lri.3) ENST00000338312
    ENST00000523120(uc003wql.4) ENST00000415216
    miRNA
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ANGPT2
      QuantiTect SYBR Green Assays in human, mouse, rat ANGPT2
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    Additional mRNA sequence: 

    AB009865.1 AF004327.1 AF187858.1 AF218015.1 AJ289780.1 AJ289781.1 AK075219.1 AK225698.1 
    AK290070.1 AK310171.1 AK312541.1 BC022490.1 BC126200.1 BC126202.1 BC143902.1 

    11 DOTS entries:

    DT.100713589  DT.87017755  DT.92470304  DT.121490400  DT.40114945  DT.207882  DT.211113  DT.40114946 
    DT.121490371  DT.121490552  DT.40268010 

    Selected AceView cDNA sequences (see all 66):

    AI825611 AA242791 CR620685 CK903581 AA252124 BI966762 BQ010977 AF187858 
    AF218015 AK075219 BC022490 AA002023 BP346252 AI809922 AI347555 BX504641 
    BG212051 CF529257 AI862415 AB009865 BP347750 BX506958 AF004327 BX391728 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    ANGPT2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGGCTGGCA
    ANGPT2 Expression
    About this image


    ANGPT2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 22) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Peripheral blood-derived hematopoietic stem cells (family)
     
     Brain (Nervous System)    fully expand to see all 8 entries
             Thalamus
     
     Bone (Muscoskeletal System)    fully expand to see all 7 entries
             Chondrocytes Zeugopod Epiphyseal End
             Bone marrow-derived mesenchymal stem cells
             HyStem+BMP4-induced SK11 cells
     
     Endothelium (Cardiovascular System)    fully expand to see all 3 entries
             Angioblasts Proepicardium
             Endothelial-like cells
     
     Lateral Plate Mesoderm (Gastrulation Derivatives)    fully expand to see all 2 entries
             Angioblasts Proepicardium
    ANGPT2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ANGPT2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.583870
        Pathway & Disease-focused RT2 Profiler PCR Arrays including ANGPT2: 
              Angiogenic Growth Factors in human mouse rat
              Cancer PathwayFinder in human mouse rat
              Liver Cancer in human mouse rat
              Angiogenesis in human mouse rat
              Adipogenesis in human mouse rat

    Primer
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ANGPT2 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Angpt21 , 5 angiopoietin 21, 5 81.01(n)1
    85.66(a)1
      8 (10.30 cM)5
    116011  NM_007426.41  NP_031452.21 
     186902635 
    chicken
    (Gallus gallus)
    Aves ANGPT21 angiopoietin 2 81.59(n)
    85.82(a)
      395610  NM_204817.1  NP_990148.1 
    lizard
    (Anolis carolinensis)
    Reptilia ANGPT26
    angiopoietin 2
    81(a)
    1 ↔ 1
    1(152033217-152101931)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004852721 angiopoietin-2-like 62.12(n)
    59.06(a)
      100485272  XM_004911568.1  XP_004911625.1 
    zebrafish
    (Danio rerio)
    Actinopterygii angpt2a1 angiopoietin 2a 64.28(n)
    57.59(a)
      101101687  NM_001278825.1  NP_001265754.1 


    ENSEMBL Gene Tree for ANGPT2 (if available)
    TreeFam Gene Tree for ANGPT2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ANGPT2 gene
    FGL22  ANGPT42  FGG2  FIBCD12  ANGPTL62  FCN32  ANGPTL22  FCN22  
    FCN12  ANGPT12  ANGPTL12  ANGPTL72  FGB2  MFAP42  FGL12  
    13 SIMAP similar genes for ANGPT2 using alignment to 2 protein entries:     ANGP2_HUMAN (see all proteins):
    angiopoietin-2    ANGPT1    AngA    FIBCD1    ANGPT4    FCN3
    FCN1    MFAP4    ANGPTL7    FGL1    FCN2    ANGPTL2
    FGL2

    Find genes that share paralogs with ANGPT2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    1 SNPs for ANGPT2    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs78132151,2,4
    ----see VAR_0490692 mis40--------

    HapMap Linkage Disequilibrium report for ANGPT2 (6357172 - 6420930 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for ANGPT2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2736532CNV Deletion23290073
    esv2422383CNV Duplication17116639
    nsv397733CNV Loss16902084
    nsv522043CNV Loss19592680
    nsv890034CNV Gain21882294
    nsv890058CNV Gain21882294
    nsv890057CNV Gain21882294

    Human Gene Mutation Database (HGMD): ANGPT2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ANGPT2
    DNA2.0 Custom Variant and Variant Library Synthesis for ANGPT2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601922    OMIM disorders: --

    Selected diseases for ANGPT2 (see all 26):    
    About MalaCards
    chorioangioma    twin-to-twin transfusion syndrome    pyogenic granuloma    placenta accreta
    placental insufficiency    lipodermatosclerosis    macular holes    proliferative diabetic retinopathy
    diabetic retinopathy    retinopathy of prematurity    mucoepidermoid carcinoma    limb ischemia
    critical limb ischemia    glioblastoma multiforme    adult respiratory distress syndrome    angiosarcoma
    hereditary hemorrhagic telangiectasia    uterine carcinosarcoma    polycystic liver disease    septic shock

    3 diseases from the University of Copenhagen DISEASES database for ANGPT2:
    Cancer     Diabetic retinopathy     Vascular disease

    Find genes that share disorders with ANGPT2           About GenesLikeMe

    Selected Novoseek inferred disease relationships for ANGPT2 gene (see all 88)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    neovascularization 74.1 34 9710115 (4), 9808608 (1), 15389527 (1), 16100571 (1) (see all 24)
    tumors 56.2 347 17440098 (8), 20197469 (6), 14767538 (6), 19815705 (5) (see all 99)
    metastasis 46.7 60 17483337 (5), 19408052 (2), 20359117 (2), 18727515 (2) (see all 31)
    proliferative diabetic retinopathy 42.6 6 15767056 (3), 15548809 (1)
    diabetic retinopathy 37.5 8 15548809 (3), 19238311 (2), 19304585 (1), 17200776 (1)
    inflammation 37.4 38 19390459 (4), 10944458 (2), 16685017 (2), 18930996 (2) (see all 18)
    glioblastoma multiforme 34.4 1 18991494 (1)
    preeclampsia 34 21 19875484 (5), 17409768 (2), 16182107 (2), 19478794 (2) (see all 7)
    glioma 33.8 46 15743799 (7), 11507079 (6), 16424009 (4), 12861074 (4) (see all 11)
    cancer 32.7 64 19216842 (4), 15196437 (4), 10922985 (3), 16614513 (2) (see all 26)

    Genetic Association Database (GAD): ANGPT2
    Human Genome Epidemiology (HuGE) Navigator: ANGPT2 (16 documents)

    Export disorders for ANGPT2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ANGPT2 gene, integrated from 10 sources (see all 682):
    (articles sorted by number of sources associating them with ANGPT2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Angiopoietin 2 is a partial agonist/antagonist of Tie2 signaling in the endothelium. (PubMed id 19223473)1, 2, 9 Yuan H.T.... Parikh S.M. (Mol. Cell. Biol. 2009)
    2. Angiopoietin-2 promoter haplotypes confer an increased risk of stroke in a Chinese Han population. (PubMed id 19341361)1, 4, 9 Chen J....Hui R. (Clin. Sci. 2009)
    3. Genetic polymorphisms of vascular endothelial growth factor and angiopoietin 2 in retinopathy of prematurity. (PubMed id 16877277)1, 4, 9 BA!nyA!sz I....SzabA^ A. (Curr. Eye Res. 2006)
    4. Characterization and expression of a novel alternatively spliced human angiopoietin-2. (PubMed id 10766762)1, 2, 9 Kim I.... Koh G.Y. (J. Biol. Chem. 2000)
    5. Biologic significance of angiopoietin-2 expression in human hepatocellular carcinoma. (PubMed id 9927494)1, 2, 9 Tanaka S....Wands J.R. (J. Clin. Invest. 1999)
    6. Genetic variants in the angiopoietin-2 gene are associated with increased risk of ARDS. (PubMed id 19271210)1, 4, 9 Su L....Christiani D.C. (Intensive Care Med 2009)
    7. Biological characterization of angiopoietin-3 and angiopoietin-4. (PubMed id 15284220)1, 2, 9 Lee H.J.... Koh G.Y. (FASEB J. 2004)
    8. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    9. Promoter variant of angiopoietin-2 and plasma angiopoietin-2 are associated with risk of stroke recurrence in lacunar infarct patients. (PubMed id 20599737)1, 4 Chen J....Hui R. (Biochem. Biophys. Res. Commun. 2010)
    10. Identification of fetal and maternal single nucleotide polymorphisms in candidate genes that predispose to spontaneous preterm labor with intact membranes. (PubMed id 20452482)1, 4 Romero R....Menon R. (Am. J. Obstet. Gynecol. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 285 HGNC: 485 AceView: ANGPT2 Ensembl:ENSG00000091879 euGenes: HUgn285
    ECgene: ANGPT2 Kegg: 285 H-InvDB: ANGPT2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ANGPT2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ANGPT2 Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/Angiopoietin

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ANGPT2 gene:
    Search GeneIP for patents involving ANGPT2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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