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ANGPT2 Gene

protein-coding GIFtS: 59

GC08M006347

angiopoietin 2
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
AGPT2 ^²
ANG-2 ^³
ANG2 ^², ⁵
Ang2 ^¹
Tie2-ligand ^²
angiopoietin-2 ^²
angiopoietin-2B ^²
angiopoietin-2a ^²

Descriptions
angiopoietin 2 ^²

External Ids
HGNC: 485¹
Entrez Gene: 285²
UniProtKB: O15123³
Ensembl: ENSG00000091879⁷

Search outside databases for aliases for ANGPT2 gene

Previous GC identifers: GC08M006424 GC08M006614

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for ANGPT2:

The protein encoded by this gene is an antagonist of angiopoietin 1 (ANGPT1) and endothelial TEK

tyrosine kinase (TIE-2, TEK). The encoded protein disrupts the vascular remodeling ability of

ANGPT1 and may induce endothelial cell apoptosis. Three transcript variants encoding three

different isoforms have been found for this gene. [provided by RefSeq]

UniProtKB/Swiss-Prot: ANGP2_HUMAN, O15123

Function: Binds to TIE2 receptor and counteracts blood vessel maturation/stability mediated by

angiopoietin-1. Its function may be context-dependent. In the absence of angiogenic inducers, such

as VEGF, ANG2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis

with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell

migration and proliferation, thus serving as a permissive angiogenic signal

Gene Wiki entry for ANGPT2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the ANGPT2 gene

Entrez Gene cytogenetic band: 8p23.1 Ensembl cytogenetic band: 8p23.1 HGNC cytogenetic band: 8p23

ANGPT2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 8 GeneLoc Exon Structure

GeneLoc location for GC08M006347: (about GC identifiers)

Start:	6,347,227 bp from pter
End:	6,408,174 bp from pter
Size:	60,948 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000008.9 NT_023736.16

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: ANGP2_HUMAN, O15123 (See protein sequence)

Recommended Name: Angiopoietin-2 precursor

Size: 496 amino acids; 56919 Da

Subcellular location: Secreted

PDB structures from and Proteopedia :

1Z3S (3D)

1Z3U (3D)

2GY7 (3D)

Secondary accessions: A0AV38 A8K205 Q9NRR7 Q9P2Y7

Alternative splicing: 2 isoforms: O15123-1 O15123-2

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (3 alternative transcripts):

NP_001112359.1 NP_001112360.1 NP_001138.1

ENSEMBL proteins:

ENSP00000314897 ENSP00000343517

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Millipore Purified and/or Recombinant ANGPT2 Protein
	Sigma-Aldrich Proteins for ANGPT2
	R&D Systems Recombinant & Natural Proteins for ANGPT2 (Angiopoietin-2)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Angiopoietin 2)
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--
GO:0005615	extracellular space	TAS	10766762

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Antibodies for ANGPT2:

	Invitrogen Antibodies for ANGPT2
	Millipore Mono- and Polyclonal Antibodies for the study of ANGPT2
	Sigma-Aldrich Antibodies for ANGPT2
	R&D Systems Antibodies for ANGPT2 (Angiopoietin-2)
	Cell Signaling Technology (CST) Antibodies for ANGPT2 (Angiopoietin-2)
	Antibodies from Abcam (Angiopoietin 2), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Novus Biologicals Antibodies for ANGPT2

Assays for ANGPT2:

	Invitrogen Assays for ANGPT2
	Browse Kits and Assays available from Millipore
	R&D Systems ELISAs for ANGPT2 (Angiopoietin-2) (see all)
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry O15123

ProtoNet protein and cluster: O15123

1 Blocks protein family: IPB002181 Fibrinogen

UniProtKB/Swiss-Prot: ANGP2_HUMAN, O15123

Similarity: Contains 1 fibrinogen C-terminal domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ANGPT2)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_001118887

Applied Biosystems Silencer® siRNAs for ANGPT2

Sigma-Aldrich siRNA and siRNA Panels for ANGPT2

Sigma-Aldrich shRNA for ANGPT2

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001118887
Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001118887
untagged cDNA clones in CMV expression vector (see all 3): NM_001118887

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001147

UniProtKB/Swiss-Prot: ANGP2_HUMAN, O15123

Function: Binds to TIE2 receptor and counteracts blood vessel maturation/stability mediated by

angiopoietin-1. Its function may be context-dependent. In the absence of angiogenic inducers, such

as VEGF, ANG2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis

with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell

migration and proliferation, thus serving as a permissive angiogenic signal

Genatlas biochemistry entry for ANGPT2:

angiopoietin 1,75kDa,secreted ligand,for the vascular endothelial restricted receptor tyrosine

kinase TEK,including phosphorylation of TEK,expressed only at sites of vascular remodeling in

adult,antagonizing ANGPT1 by blocking its ability to activate its ligand

7 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Angpt2):

	digestive/alimentary	homeostasis/metabolism	immune system	lethality-postnatal
skin/coat/nails	vision/eye

1 Gene Ontology (GO) molecular function term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005102	receptor binding	TAS	9204896 10766762

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

2 Sigma-Aldrich "Your Favorite Gene" Pathways for ANGPT2 (Your Favorite Gene powered by Ingenuity)

IL-8 Signaling
Angiopoietin Signaling

GeneDecks ANGPT2 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for ANGPT2

4 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001525	angiogenesis	IEA	--
GO:0007165	signal transduction	TAS	10766762
GO:0007275	multicellular organismal development	IEA	--
GO:0030154	cell differentiation	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for ANGPT2
10/16 Novoseek chemical compound relationships for ANGPT2 gene (see all 16 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
p00055	57.92	2	16179272 (1), 15112366 (1)
tyrosine	54.74	54	19223473 (2), 11397875 (1), 15743796 (1), 11838839 (1) (see all 37)
ribonucleic acid	19.92	2	11095472 (1), 11297624 (1)
methylglyoxal	15.71	2	16413606 (1), 17387784 (1)
wortmannin	11.21	6	16447257 (1), 17215522 (1), 11002428 (1), 16826573 (1)
guanylate	6.60	3	17526946 (1), 18567719 (1), 16943586 (1)
atp	2.56	1	17440098 (1)
calcium	0.82	3	19112163 (1), 15840779 (1)
oxygen	0.00	10	11778652 (3), 11141343 (1), 12162728 (1), 12213726 (1) (see all 5)
fibrinogen	0.00	3	17240049 (2)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ANGPT2)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_001118887

Sigma-Aldrich siRNA and siRNA Panels for ANGPT2

Sigma-Aldrich shRNA for ANGPT2

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001118887 NM_001118888 NM_001147

REFSEQ mRNAs for ANGPT2 gene (3 alternative transcripts):

NM_001118887.1 NM_001118888.1 NM_001147.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001118887 NM_001118888 NM_001147

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001118887
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001118887
                                 untagged cDNA clones in CMV expression vector (see all 3): NM_001118887

Additional cDNA sequence:

AB009865.1 AF004327.1 AF187858.1 AF218015.1 AJ289780.1 AJ289781.1 AK075219.1 AK225698.1

AK290070.1 AK310171.1 AK312541.1 BC022490.1 BC126200.1 BC126202.1 BC143902.1 CR620685.1

12 DOTS entries:

DT.100713589 DT.87017755 DT.92470304 DT.121490400 DT.40114945 DT.95155674 DT.207882 DT.211113

DT.40114946 DT.121490371 DT.121490552 DT.40268010

24/66 AceView cDNA sequences (see all 66 ):

AA252124 AI825611 BQ010977 AA242791 CR620685 BI966762 CK903581 AA125872

BU753418 BE145701 CK903582 BI962932 AI623578 AI862415 AA002023 CB047127

BX506958 CF529257 CB528341 BP347750 BX504641 AL573084 AF004327 AW450199

highest scoring ESTs for ANGPT2:

AF004327 AB009865 AF187858 AF218015 AI825611 AJ289781 AK075219 AW813491 BC022490 BF085046

Unigene Cluster for ANGPT2:

Angiopoietin 2

Hs.583870 [show with all ESTs]

Unigene Representative Sequence: NM_001147

GeneLoc Exon Structure

2 Ensembl transcripts including schematic representations:

ENST00000325203 ENST00000338312

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

ANGPT2 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ANGPT2

¹ / ² / ³

13 probe-sets matching ANGPT2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
47853_at²^{, 3}	U95-B	1	1.00	1.00	0.51	0.38	AA156409	0.20	0.50	0.38	1
37461_at²^{, 3}	U95-A	1	1.00	1.00	0.92	0.89	AF004327	1.00	1.00	1.00	1
1951_at²^{, 3}	U95-A	1	1.00	1.00	0.92	0.81	AF004327	1.00	1.00	1.00	1
53731_at²^{, 3}	U95-C	1	1.00	1.00	0.91	1.17	AA083514	0.20	0.50	0.38	1
58716_at²^{, 3}	U95-C	1	0.88	1.00	0.80	1.18	AI825611	0.80	1.00	0.91	1
205572_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_001147	0.60	1.00	0.82	1
236034_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AA083514	0.20	0.50	0.38	1
211148_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AF187858	0.80	1.00	0.91	1
237261_at²	U133-B	1	0.91	1.00	--	--	--	--	--	--	--
205572_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
236034_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
211148_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
237261_at²	U133Plus2	1	0.91	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GTGGCTGGCA

SOURCE GeneReport for Unigene cluster: Hs.583870
Expression variation in blood from EXPOLDB for ANGPT2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ANGPT2 gene from 5/7 species (see all 7 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	ANGPT2¹	--	angiopoietin 2	88.62(n) 92.53(a)	607616 XM_844197.1 XP_849290.1
chimpanzee (Pan troglodytes)	ANGPT2¹	--	angiopoietin 2	99.39(n) 99.8(a)	742508 XM_001145488.1 XP_001145488.1
cow (Bos taurus)	ANGPT2¹	--	angiopoietin 2	87.47(n) 90.1(a)	282141 XM_864610.2 XP_869703.1
rat (Rattus norvegicus)	Angpt2¹	--	angiopoietin 2	80.31(n) 86.49(a)	89805 XM_344544.3 XP_344545.3
mouse (Mus musculus)	Angpt2^{1, 5}	8 (9.00 cM)⁵	angiopoietin 2^{1, 5}	80.51(n)¹ 85.28(a)¹	11601¹ NM_007426.3¹ NP_031452.2¹ AF004326⁵ AK019860⁵ (see all 12)

About this table Species with no ortholog for ANGPT2

ENSEMBL Gene Tree for ANGPT2

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for ANGPT2 gene

ANGPT4² ANGPT1²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 601922

10/86 Novoseek disease relationships for ANGPT2 gene (see all 86 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
neovascularization	75.80	34	9710115 (4), 9808608 (1), 15389527 (1), 16100571 (1) (see all 24)
tumors	54.90	283	17440098 (8), 14767538 (6), 12808060 (5), 16552969 (5) (see all 99)
metastasis	45.90	53	17483337 (5), 18727515 (2), 14767538 (2), 16465407 (2) (see all 27)
proliferative diabetic retinopathy	42.02	6	15767056 (3), 15548809 (1)
diabetic retinopathy	36.15	4	15548809 (3), 17200776 (1)
inflammation	36.02	21	10944458 (2), 16685017 (2), 17287278 (1), 19025590 (1) (see all 14)
retinal neovascularization	35.92	2	17200776 (1)
placental insufficiency	35.37	1	17949380 (1)
glioma	34.41	45	15743799 (7), 11507079 (6), 16424009 (4), 12861074 (4) (see all 10)
vascular proliferation	32.41	2	11348459 (1)

About this table

Genetic Association Database: ANGPT2
Human Genome Epidemiology Navigator: ANGPT2 (11 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/473 PubMed articles for ANGPT2 gene (see all 473 ):

An Angiopoietin-2 gene polymorphism in unexplained intrauterine fetal death: a multi-center study. (PubMed id 15694966)^{1, 3, 6} Huber A....Hefler L. (2005)
Biologic significance of angiopoietin-2 expression in human hepatocellular carcinoma. (PubMed id 9927494)^{1, 3, 4} Tanaka S....Wands J.R. (1999)
Characterization and expression of a novel alternatively spliced human angiopoietin-2. (PubMed id 10766762)^{1, 3, 4} Kim I.... Koh G.Y. (2000)
Polymorphism of the p53 tumor suppressor gene is associated with susceptibility to uterine leiomyoma. (PubMed id 16009172)^{1, 3, 6} Denschlag D....Pietrowski D. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Angiopoietin-2 polymorphism in women with idiopathic recurrent miscarriage. (PubMed id 14556828)^{3, 6} Pietrowski D....Keck C. (2003)
Endothelial Tie2/Tek ligands angiopoietin-1 (ANGPT1) and angiopoietin-2 (ANGPT2): regional localization of the human genes to 8q22.3-q23 and 8p23. (PubMed id 9545648)^{2, 3} Cheung A.H....Marsden P.A. (1998)
Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis. (PubMed id 9204896)^{3, 4} Maisonpierre P.C.... Yancopoulos G.D. (1997)
Angiopoietin 2 expression in invasive ductal carcinoma of the breast: its relationship to the VEGF expression and microvessel density. (PubMed id 16538528)^{1, 3} Tsutsui S....Mori M. (2006)
Overexpression of Ang-2 mRNA in non-small cell lung cancer: association with angiogenesis and poor prognosis. (PubMed id 15375511)^{1, 3} Takanami I. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 285	HGNC: 485	AceView: ANGPT2	Ensembl:ENSG00000091879	euGenes: HUgn285
ECgene: ANGPT2	H-InvDB: ANGPT2

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for ANGPT2	Genetics and Cytogenetics in Oncology and Haematology
Wikipedia	http://en.wikipedia.org/wiki/Angiopoietin

Licensable Technologies for ANGPT2
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for ANGPT2:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ANGPT2-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for ANGPT2		Antibodies for ANGPT2
	Explore super-pooled esiRNAs		Proteins for ANGPT2
	Lentivirus-delivered shRNAs for ANGPT2		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for ANGPT2 (Angiopoietin-2)

	Recombinant Proteins (Angiopoietin 2)
	Antibodies (Angiopoietin 2)

Search OriGene for ANGPT2

Search Tocris compounds for ANGPT2

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for ANGPT2

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ANGPT2 Gene

protein-coding GIFtS: 59

Aliases &
Descriptions
for ANGPT2

Summaries
for ANGPT2

Genomic Location
for ANGPT2

Proteins
for ANGPT2

Protein Domains/
Families
for ANGPT2

Gene Function
for ANGPT2

Pathways & Interactions
for ANGPT2

Drugs & Compounds
for ANGPT2

Transcripts
for ANGPT2

Expression
for ANGPT2

Orthologs
for ANGPT2

Paralogs
for ANGPT2

SNPs/Variants
for ANGPT2

Disorders & Mutations
for ANGPT2

Medical News
for ANGPT2

Publications
for ANGPT2

Search for ANGPT2

Genome Databases showing ANGPT2

Other Databases showing ANGPT2

Specialized Databases showing ANGPT2

Licensable Technologies
for ANGPT2

Services
for ANGPT2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ANGPT2 Gene

protein-coding GIFtS: 59

Aliases & Descriptionsfor ANGPT2

Summariesfor ANGPT2

Genomic Locationfor ANGPT2

Proteinsfor ANGPT2

Protein Domains/Familiesfor ANGPT2

Gene Functionfor ANGPT2

Pathways & Interactionsfor ANGPT2

Drugs & Compoundsfor ANGPT2

Transcriptsfor ANGPT2

Expression for ANGPT2

Orthologsfor ANGPT2

Paralogsfor ANGPT2

SNPs/Variantsfor ANGPT2

Disorders & Mutationsfor ANGPT2

Medical Newsfor ANGPT2

Publicationsfor ANGPT2

Search for ANGPT2

Genome Databases showing ANGPT2

Other Databases showing ANGPT2

Specialized Databases showing ANGPT2

Licensable Technologiesfor ANGPT2

Servicesfor ANGPT2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ANGPT2

Summaries
for ANGPT2

Genomic Location
for ANGPT2

Proteins
for ANGPT2

Protein Domains/
Families
for ANGPT2

Gene Function
for ANGPT2

Pathways & Interactions
for ANGPT2

Drugs & Compounds
for ANGPT2

Transcripts
for ANGPT2

Expression
for ANGPT2

Orthologs
for ANGPT2

Paralogs
for ANGPT2

SNPs/Variants
for ANGPT2

Disorders & Mutations
for ANGPT2

Medical News
for ANGPT2

Publications
for ANGPT2

Licensable Technologies
for ANGPT2

Services
for ANGPT2