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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ANGPT1 Gene

protein-coding   GIFtS: 70
GCID: GC08M108330

Angiopoietin 1

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Angiopoietin 11 2     AGPT2
ANG-12 3     angiopoietin-12
ANG12 5     KIAA00033
AGP12     

External Ids:    HGNC: 4841   Entrez Gene: 2842   Ensembl: ENSG000001541887   OMIM: 6016675   UniProtKB: Q153893   

Export aliases for ANGPT1 gene to outside databases

Previous GC identifers: GC08M107246 GC08M108328 GC08M107930 GC08M108218 GC08M103581


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ANGPT1 Gene:
Angiopoietins are proteins with important roles in vascular development and angiogenesis. All angiopoietins bind
with similar affinity to an endothelial cell-specific tyrosine-protein kinase receptor. The protein encoded by
this gene is a secreted glycoprotein that activates the receptor by inducing its tyrosine phosphorylation. It
plays a critical role in mediating reciprocal interactions between the endothelium and surrounding matrix and
mesenchyme and inhibits endothelial permeability. The protein also contributes to blood vessel maturation and
stability, and may be involved in early development of the heart. Alternative splicing results in multiple
transcript variants encoding distinct isoforms.(provided by RefSeq, Dec 2010)

GeneCards Summary for ANGPT1 Gene: 
ANGPT1 (angiopoietin 1) is a protein-coding gene. Diseases associated with ANGPT1 include chorioangioma, and funisitis, and among its related super-pathways are Development Angiopoietin - Tie2 signaling and MIF Mediated Glucocorticoid Regulation. GO annotations related to this gene include receptor tyrosine kinase binding. An important paralog of this gene is FGL2.

UniProtKB/Swiss-Prot: ANGP1_HUMAN, Q15389
Function: Binds and activates TEK/TIE2 receptor by inducing its dimerization and tyrosine phosphorylation. Plays
an important role in the regulation of angiogenesis, endothelial cell survival, proliferation, migration,
adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular
quiescence. Required for normal angiogenesis and heart development during embryogenesis. After birth, activates
or inhibits angiogenesis, depending on the context. Inhibits angiogenesis and promotes vascular stability in
quiescent vessels, where endothelial cells have tight contacts. In quiescent vessels, ANGPT1 oligomers recruit
TEK to cell-cell contacts, forming complexes with TEK molecules from adjoining cells, and this leads to
preferential activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascades. In migrating
endothelial cells that lack cell-cell adhesions, ANGT1 recruits TEK to contacts with the extracellular matrix,
leading to the formation of focal adhesion complexes, activation of PTK2/FAK and of the downstream kinases
MAPK1/ERK2 and MAPK3/ERK1, and ultimately to the stimulation of sprouting angiogenesis. Mediates blood vessel
maturation/stability. Implicated in endothelial developmental processes later and distinct from that of VEGF.
Appears to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding
matrix and mesenchyme

Gene Wiki entry for ANGPT1 (Angiopoietin 1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NT_008046.16  NC_018919.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ANGPT1 gene promoter:
         E2F-4   E2F-3a   E2F-5   Lmo2   IRF-1   E2F-2   IRF-2   E2F   E2F-1   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidANGPT1 promoter sequence
   Search SABiosciences Chromatin IP Primers for ANGPT1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ANGPT1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q23.1   Ensembl cytogenetic band:  8q23.1   HGNC cytogenetic band: 8q23.1

ANGPT1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ANGPT1 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M108330:  view genomic region     (about GC identifiers)

Start:
108,261,710 bp from pter      End:
108,510,283 bp from pter
Size:
248,574 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ANGP1_HUMAN, Q15389 (See protein sequence)
Recommended Name: Angiopoietin-1 precursor  
Size: 498 amino acids; 57513 Da
Subunit: Homooligomer. Interacts with TEK/TIE2
Subcellular location: Secreted
Miscellaneous: It may have a potential therapeutic utility since it can be used for specifically targeting tumor
vasculature or for promoting angiogenic processes in certain organs such as an ischemic heart
Sequence caution: Sequence=BAA02793.2; Type=Erroneous initiation;
3 PDB 3D structures from and Proteopedia for ANGPT1:
4EPU (3D)        4JYO (3D)        4K0V (3D)    
Secondary accessions: Q5HYA0
Alternative splicing: 2 isoforms:  Q15389-1   Q15389-2   

Explore the universe of human proteins at neXtProt for ANGPT1: NX_Q15389

Explore proteomics data for ANGPT1 at MOPED 

Post-translational modifications:

  • UniProtKB: Glycosylated
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q15389

  • ANGPT1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ANGPT1 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001137.2  NP_001186788.1  

    ENSEMBL proteins: 
     ENSP00000428340   ENSP00000297450   ENSP00000430750   ENSP00000429349   ENSP00000428908  
    Reactome Protein details: Q15389
    Human Recombinant Protein Products for ANGPT1: 
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    R&D Systems Recombinant & Natural Proteins for ANGPT1 (Angiopoietin-1)
    Enzo Life Sciences proteins for ANGPT1
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    Novus Biologicals ANGPT1 Proteins
    Novus Biologicals ANGPT1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for ANGPT1
    Cloud-Clone Corp. Proteins for ANGPT1 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IDA10218485
    GO:0005886plasma membrane IDA19424712
    GO:0005902microvillus IDA19424712
    GO:0045121membrane raft IDA19615361

    ANGPT1 for ontologies           About GeneDecksing



    ANGPT1 Antibody Products: 
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    R&D Systems Antibodies for ANGPT1 (Angiopoietin-1)
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    Abcam antibodies for ANGPT1
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    ThermoFisher Antibodies for ANGPT1
    LSBio Antibodies in human, mouse, rat for ANGPT1 

    Assay Products for ANGPT1: 
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    R&D Systems Flow Cytometry Kits for ANGPT1 (Angiopoietin-1)         (see all)
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    Cloud-Clone Corp. ELISAs for ANGPT1 
    Cloud-Clone Corp. CLIAs for ANGPT1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    FIBC: Fibrinogen C domain containing

    4 InterPro protein domains:
     IPR020837 Fibrinogen_CS
     IPR014715 Fibrinogen_a/b/g_C_2
     IPR002181 Fibrinogen_a/b/g_C_dom
     IPR014716 Fibrinogen_a/b/g_C_1

    Graphical View of Domain Structure for InterPro Entry Q15389

    ProtoNet protein and cluster: Q15389

    1 Blocks protein domain: IPB002181 Fibrinogen

    UniProtKB/Swiss-Prot: ANGP1_HUMAN, Q15389
    Similarity: Contains 1 fibrinogen C-terminal domain


    ANGPT1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ANGP1_HUMAN, Q15389
    Function: Binds and activates TEK/TIE2 receptor by inducing its dimerization and tyrosine phosphorylation. Plays
    an important role in the regulation of angiogenesis, endothelial cell survival, proliferation, migration,
    adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular
    quiescence. Required for normal angiogenesis and heart development during embryogenesis. After birth, activates
    or inhibits angiogenesis, depending on the context. Inhibits angiogenesis and promotes vascular stability in
    quiescent vessels, where endothelial cells have tight contacts. In quiescent vessels, ANGPT1 oligomers recruit
    TEK to cell-cell contacts, forming complexes with TEK molecules from adjoining cells, and this leads to
    preferential activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascades. In migrating
    endothelial cells that lack cell-cell adhesions, ANGT1 recruits TEK to contacts with the extracellular matrix,
    leading to the formation of focal adhesion complexes, activation of PTK2/FAK and of the downstream kinases
    MAPK1/ERK2 and MAPK3/ERK1, and ultimately to the stimulation of sprouting angiogenesis. Mediates blood vessel
    maturation/stability. Implicated in endothelial developmental processes later and distinct from that of VEGF.
    Appears to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding
    matrix and mesenchyme

         Genatlas biochemistry entry for ANGPT1:
    angiopoietin 1,75kDa,secreted ligand for the vascular endothelial restricted receptor tyrosine kinase
    TEK,including phosphorylation of TEK,widely expressed,involved in late stages of angiogenesis,promoting
    angiogenic remodeling as well as vessel maturation and stabilization

         Summary:
    During embryonic development, ANGPT1 as signaling molecule is secreted from the following cells: Mural Cells in Splanchnic Mesoderm, Pulmonary Vascular Smooth Muscle Cells in Pulmonary Capillary Plexus (see all 3).

    It affects the following cells: Angioblasts in Embryonic Capillary Plexus, Arterial Endothelial Cells in Pulmonary Capillary Plexus (see all 3).

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding ----
    GO:0030971receptor tyrosine kinase binding IPI19922791
         
    ANGPT1 for ontologies           About GeneDecksing


    Phenotypes:
         7 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Angpt1):
     cardiovascular system  embryogenesis  growth/size  mortality/aging  muscle 
     nervous system  renal/urinary system 

    ANGPT1 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ANGPT1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ANGPT1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ANGPT1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ANGPT1 

    miRNA
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    8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate ANGPT1 (see all 10):
    hsa-miR-448 hsa-miR-4328 hsa-miR-340 hsa-miR-211 hsa-miR-153 hsa-miR-1244 hsa-miR-96* hsa-miR-204
    SwitchGear 3'UTR luciferase reporter plasmidANGPT1 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Gene Editing
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): ANGPT1 (NM_001199859)
    Sino Biological Human cDNA Clone for ANGPT1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ANGPT1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ANGPT1
    Sirion Biotech Customized lentivirus for stable overexpression of ANGPT1 
                         Customized lentivirus expression plasmids for stable overexpression of ANGPT1 

    Cell Line
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANGPT1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ANGPT1 About   (see all 14)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Development PDGF signaling via STATs and NF-kB
    Development Angiopoietin - Tie2 signaling0.38
    Angiopoietin receptor Tie2-mediated signaling0.32
    Angiopoietin-TIE2 Signaling0.36
    2PEDF Induced Signaling
    MIF Mediated Glucocorticoid Regulation0.94
    NFAT Signaling and Lymphocyte Interactions0.57
    MIF Regulation of Innate Immune Cells0.94
    PGC1Alpha Pathway0.51
    PEDF Induced Signaling0.73
    STAT3 Pathway0.47
    all-trans-Retinoic Acid Signaling in Brain0.71
    Endothelin-1 Signaling Pathway0.46
    3TGF-Beta Pathway
    TGF-Beta Pathway0.60
    JNK Pathway0.51
    MAPK Family Pathway0.60
    Regulation of eIF4 and p70S6K0.43
    JAK-STAT Pathway0.57
    SOCS Pathway0.40
    4Akt Signaling
    Akt Signaling0.60
    Tec Kinases Signaling0.55
    p38 Signaling0.60
    5Rho Family GTPases
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for ANGPT1
        Development Angiopoietin - Tie2 signaling
    G-protein signaling H-RAS regulation pathway

    5/26 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for ANGPT1 (see all 26)
        Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    NFAT Signaling and Lymphocyte Interactions
    JNK Pathway

    2 GeneGo (Thomson Reuters) Pathways for ANGPT1
        G-protein signaling H-RAS regulation pathway
    Development Angiopoietin - Tie2 signaling

    2 BioSystems Pathways for ANGPT1
        Angiogenesis
    Angiopoietin receptor Tie2-mediated signaling


    3        Reactome Pathways for ANGPT1
        Hemostasis
    Cell surface interactions at the vascular wall
    Tie2 Signaling


    3         Kegg Pathways  (Kegg details for ANGPT1):
        HIF-1 signaling pathway
    PI3K-Akt signaling pathway
    Rheumatoid arthritis


    ANGPT1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ANGPT1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/35 Interacting proteins for ANGPT1 (Q153893 ENSP000002974504) via UniProtKB, MINT, STRING, and/or I2D (see all 35)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TEKQ027633, ENSP000003839774I2D: score=4 STRING: ENSP00000383977
    ANGPT2O151233, ENSP000003148974I2D: score=1 STRING: ENSP00000314897
    ITGA5P086483, ENSP000002933794I2D: score=2 STRING: ENSP00000293379
    CRKENSP000003005744STRING: ENSP00000300574
    DOK2ENSP000002764204STRING: ENSP00000276420
    About this table

    Gene Ontology (GO): 5/31 biological process terms (GO ID links to tree view) (see all 31):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis ----
    GO:0001701in utero embryonic development IEA--
    GO:0001936NOT regulation of endothelial cell proliferation IDA8980223
    GO:0002040sprouting angiogenesis IDA10218485
    GO:0002092positive regulation of receptor internalization IDA19424712

    ANGPT1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ANGPT1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ANGPT1 (ANGP1)

    10/43 Novoseek inferred chemical compound relationships for ANGPT1 gene (see all 43)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    vegf 88.9 788 14584044 (8), 19564638 (8), 19160387 (7), 15367176 (7) (see all 99)
    tyrosine 63.6 109 18848573 (3), 17595127 (3), 10706866 (2), 8980223 (2) (see all 65)
    ameroid 52.8 1 16547766 (1)
    matrigel 49 4 16754788 (1), 20098680 (1), 15501241 (1), 12759249 (1)
    ly294002 45.7 3 19028450 (1), 15763944 (1), 12514118 (1)
    wortmannin 42.5 3 16447257 (1), 19379779 (1), 16826573 (1)
    phosphatidylinositol 35.3 20 17599743 (3), 11729102 (3), 16000309 (3), 16372478 (2) (see all 9)
    tween 28.6 4 16363251 (1), 16164572 (1)
    gelfoam 17.6 2 12810673 (2)
    progestin 16.1 3 10587365 (1), 12213726 (1)

    Search CenterWatch for drugs/clinical trials and news about ANGPT1 / ANGP1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    About This Section

    REFSEQ mRNAs for ANGPT1 gene (3 alternative transcripts): 
    NM_001146.3  NM_001199859.1  NM_139290.1  

    Unigene Cluster for ANGPT1:

    Angiopoietin 1
    Hs.369675  [show with all ESTs]
    Unigene Representative Sequence: BX648814
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000517746(uc011lhv.2) ENST00000297450(uc003ymn.3 uc003ymo.3)
    ENST00000520734 ENST00000520052 ENST00000518386 ENST00000521950(uc003ymp.4)
    ENST00000522400 ENST00000520033
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ANGPT1
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ANGPT1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ANGPT1

    Additional mRNA sequence: 

    AB084454.1 AK300319.1 AK304717.1 AY121504.1 AY124380.1 BC029406.1 BC152411.1 BC152419.1 
    BX648814.1 D13628.2 U83508.1 

    7 DOTS entries:

    DT.409144  DT.92048735  DT.100655583  DT.91826443  DT.95268809  DT.95268811  DT.95268810 

    24/75 AceView cDNA sequences (see all 75):

    CB959296 AA903299 BF435199 D13628 CA442002 NM_139290 U83508 AB084454 
    CA391291 BF195841 AW044503 AY121504 AI658562 BF224438 BU625006 AY124380 
    BU627306 AL700970 AI753541 NM_001146 AW296269 CA394153 CD652714 AW195609 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for ANGPT1 (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b · 10c · 10d ^ 11 ^ 12a · 12b · 12c · 12d
    SP1:                    -     -                 -                                   -                             -     -                                 
    SP2:                    -     -                 -                                   -                             -     -                                 
    SP3:                                                                                -           -     -           -     -                                 
    SP4:                                                                                -                                                                     
    SP5:                                                                    -     -     -                 -     -     -     -                                 


    ECgene alternative splicing isoforms for ANGPT1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ANGPT1 expression in normal human tissues (normalized intensities)      ANGPT1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGTTTCTAT
    ANGPT1 Expression
    About this image


    ANGPT1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/27 selected tissues (see all 27) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 6 entries
             Bone marrow-derived mesenchymal stem cells (Stemedyne-MSC)
             HyStem+BMP4-induced MEL2 cells
             Human Calvarial Osteoblasts (HCO)   
             bone marrow   
     
     Blood (Cardiovascular System)    fully expand to see all 6 entries
             Hematopoietic Stem Cells Liver Bud
             Peripheral blood-derived hematopoietic stem cells
             cord blood   
     
     Mesenchymal Stem Cells
             Bone marrow-derived mesenchymal stem cells (Stemedyne-MSC)
             Human Mesenchymal Stem Cells (hMSC)-1   
     
     Smooth Muscle (Muscoskeletal System)    fully expand to see all 3 entries
             Pulmonary Vascular Smooth Muscle Cells Pulmonary Capillary Plexus
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 3 entries
             Myoblasts Mandibular Arch Muscles

    See ANGPT1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ANGPT1

    SOURCE GeneReport for Unigene cluster: Hs.369675
        SABiosciences Expression via Pathway-Focused PCR Arrays including ANGPT1 (see all 6): 
              Endothelial Cell Biology in human mouse rat
              Angiogenic Growth Factors in human mouse rat
              Wound Healing in human mouse rat
              Cancer PathwayFinder in human mouse rat
              Angiogenesis in human mouse rat

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANGPT1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ANGPT1 gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Angpt11 , 5 angiopoietin 11, 5 91.82(n)1
    97.38(a)1
      15 (16.69 cM)5
    116001  NM_009640.31  NP_033770.21 
     424247235 
    chicken
    (Gallus gallus)
    Aves ANGPT11 angiopoietin 1 83.9(n)
    91.75(a)
      395129  NM_001199447.1  NP_001186376.1 
    lizard
    (Anolis carolinensis)
    Reptilia ANGPT16
    Uncharacterized protein
    89(a)
    1 ↔ 1
    4(11613060-11773040)
    zebrafish
    (Danio rerio)
    Actinopterygii angpt12 angiopoietin 1 74.33(n)   114407  AF379602.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG103593   -- 41(a)   63E5   --


    ENSEMBL Gene Tree for ANGPT1 (if available)
    TreeFam Gene Tree for ANGPT1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ANGPT1 gene
    FGL22  ANGPT42  FIBCD12  ANGPTL62  FCN32  ANGPTL22  FCN22  FCN12  
    ANGPTL12  ANGPTL72  ANGPT22  MFAP42  
    18/19 SIMAP similar genes for ANGPT1 using alignment to 4 protein entries:     ANGP1_HUMAN (see all proteins) (see all similar genes):
    AngA    ANGPT2    ANGPT4    FCN1    FCN3    FCN2
    ANGPTL7    ANGPTL1    TNXB    ANGPTL2    ANGPTL4    MFAP4
    TNC    FGL1    LFIRE1    ANGPTL6    FIBCD1    FGL2

    ANGPT1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/5007 SNPs in ANGPT1 are shown (see all 5007)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1456722121,2
    --103590204(+) TTTTG-/TTTC  
            
    TTTTT
    2 -- int10--------
    rs20229611,2
    C,A--103590207(-) AAAAAA/GAAACA 2 -- int1 trp32Minor allele frequency- G:0.00WA NA 4
    rs1997100441,2
    --103590207(+) TGTTT-/CTTTTT 2 -- int10--------
    rs339244391,2
    C--103590210(+) TCTTT-/GTTTGT 2 -- int10--------
    rs50033681,2
    C--103590214(+) TTTTTT/GTTTGT 2 -- int11Minor allele frequency- G:0.00NA 2
    rs715228021,2
    C--103590222(+) TGTTTG/TTTTGT 2 -- int11Minor allele frequency- T:0.50NA 2
    rs1425068931,2
    C--103590253(+) TTCTT-/TCTCTCT 2 -- int10--------
    rs361904081,2
    C--103595684(+) GTTTC-/A/AAA 
            
    AAAAA
    4 -- int1 cds11NA 2
    rs1400083441,2
    C--103599041(+) CTCAC-/TAATA 
            
    AAGAC
    2 -- int10--------
    rs799149761,2
    C--103608956(+) GATTTA/TAAAAA 2 -- int10--------

    HapMap Linkage Disequilibrium report for ANGPT1 (108261710 - 108510283 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/23 variations for ANGPT1 (see all 23):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv996692CNV Deletion20482838
    esv2737413CNV Deletion23290073
    esv2737410CNV Deletion23290073
    esv2508144CNV Deletion19546169
    esv1949347CNV Deletion18987734
    dgv1301e199CNV Deletion23128226
    esv2737412CNV Deletion23290073
    esv1401355CNV Deletion17803354
    esv5345CNV Deletion18987735
    esv4787CNV Deletion18987735


    Human Gene Mutation Database (HGMD): ANGPT1
    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for ANGPT1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 601667    OMIM disorders: --

    20/98 diseases for ANGPT1 (see all 98):    About MalaCards
    chorioangioma    funisitis    lipodermatosclerosis    polycystic liver disease
    pyogenic granuloma    vascular malformations    gastric ulcer    angioimmunoblastic t-cell lymphoma
    angiosarcoma    proliferative diabetic retinopathy    diabetic retinopathy    retinopathy of prematurity
    sickle cell disease    ischemia    arteriosclerosis    gingival overgrowth
    cerebral malaria    bronchopulmonary dysplasia    gingivitis    hepatopulmonary syndrome

    2 diseases from the University of Copenhagen DISEASES database for ANGPT1:
    Vascular disease     Cancer

    ANGPT1 for disorders           About GeneDecksing

    10/85 Novoseek inferred disease relationships for ANGPT1 gene (see all 85)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    neovascularization 76.6 31 9710115 (4), 17376288 (2), 9808608 (1), 11677194 (1) (see all 20)
    tumors 48.5 204 19018775 (7), 12810673 (6), 19487284 (5), 11245414 (5) (see all 81)
    metastasis 35 16 19487284 (3), 19916173 (3), 16465407 (2), 14607656 (1) (see all 8)
    uterine bleeding 32.7 1 20233519 (1)
    acute respiratory distress 31.7 2 19543148 (1), 17322110 (1)
    preeclampsia 30.5 10 19875484 (2), 16363251 (1), 17409768 (1), 19478794 (1) (see all 6)
    inflammation 30.5 37 16741035 (3), 17322110 (3), 19772173 (2), 17560831 (2) (see all 23)
    hypertension pulmonary 25.5 21 11436038 (4), 15678035 (3), 14759414 (3), 12571257 (2) (see all 8)
    proliferative diabetic retinopathy 25.2 1 15774928 (1)
    respiratory distress syndrome 24.6 2 19543148 (1), 17322110 (1)

    Genetic Association Database (GAD): ANGPT1
    Human Genome Epidemiology (HuGE) Navigator: ANGPT1 (7 documents)

    Export disorders for ANGPT1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ANGPT1 gene, integrated from 9 sources (see all 628):
    (articles sorted by number of sources associating them with ANGPT1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A functional variant in the 3'-UTR of angiopoietin-1 might reduce stroke risk by interfering with the binding efficiency of microRNA 211. (PubMed id 20378606)1, 4, 9 Chen J....Hui R. (2010)
    2. Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning. (PubMed id 8980223)1, 2, 9 Davis S....Yancopoulos G.D. (1996)
    3. Biological characterization of angiopoietin-3 and angiopoietin-4. (PubMed id 15284220)1, 2, 9 Lee H.J....Koh G.Y. (2004)
    4. Physiogenomic analysis of statin-treated patients: do main-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol? (PubMed id 20602615)1, 4 RuaA+o G....Wu A.H. (2010)
    5. Genetic Risk Factors for Hepatopulmonary Syndrome in Patients With Advanced Liver Disease. (PubMed id 20346360)1, 4 Roberts K.E....Fallon M.B. (2010)
    6. Physiogenomic comparison of edema and BMI in patients receiving rosiglitazone or pioglitazone. (PubMed id 18996102)1, 4 RuaA+o G....Hanks S. (2009)
    7. Differential function of Tie2 at cell-cell contacts and cell-substratum contacts regulated by angiopoietin-1. (PubMed id 18425120)1, 2 Fukuhara S....Mochizuki N. (2008)
    8. Angiopoietin-1 and angiopoietin-2 share the same binding domains in the Tie-2 receptor involving the first Ig-like loop and the epidermal growth factor-like repeats. (PubMed id 12427764)1, 2 Fiedler U....Augustin H.G. (2003)
    9. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (2002)
    10. Endothelial Tie2/Tek ligands angiopoietin-1 (ANGPT1) and angiopoietin-2 (ANGPT2): regional localization of the human genes to 8q22.3-q23 and 8p23. (PubMed id 9545648)1, 3 Cheung A.H....Marsden P.A. (1998)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 284 HGNC: 484 AceView: ANGPT1 Ensembl:ENSG00000154188 euGenes: HUgn284
    ECgene: ANGPT1 Kegg: 284 H-InvDB: ANGPT1

    (According to HUGE)
    About This Section
    HUGE: KIAA0003

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ANGPT1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ANGPT1 Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/Angiopoietin

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ANGPT1 gene:
    Search GeneIP for patents involving ANGPT1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

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