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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ANGPT1 Gene

protein-coding   GIFtS: 68
GCID: GC08M108330

angiopoietin 1
 Explore 112 diseases affiliated with
ANGPT1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ANGPT1    

Aliases
for ANGPT1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Angiopoietin 11 2     Ang11
KIAA00031 3     AGP12
ANG-12 3     AGPT2
ANG12 5     Angiopoietin-11

External Ids:    HGNC: 4841   Entrez Gene: 2842   Ensembl: ENSG000001541887   OMIM: 6016675   UniProtKB: Q153893   

Export aliases for ANGPT1 gene to outside databases

Previous GC identifers: GC08M107246 GC08M108328 GC08M107930 GC08M108218 GC08M103581


Summaries
for ANGPT1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for ANGPT1:
Angiopoietins are proteins with important roles in vascular development and angiogenesis. All angiopoietins bind with
similar affinity to an endothelial cell-specific tyrosine-protein kinase receptor. The protein encoded by this gene is
a secreted glycoprotein that activates the receptor by inducing its tyrosine phosphorylation. It plays a critical role
in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme and inhibits
endothelial permeability. The protein also contributes to blood vessel maturation and stability, and may be involved
in early development of the heart. Alternative splicing results in multiple transcript variants encoding distinct
isoforms.(provided by RefSeq, Dec 2010)

UniProtKB/Swiss-Prot: ANGP1_HUMAN, Q15389
Function: Binds and activates TEK/TIE2 receptor by inducing its dimerization and tyrosine phosphorylation. Plays an
important role in the regulation of angiogenesis, endothelial cell survival, proliferation, migration, adhesion and
cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence. Required for
normal angiogenesis and heart development during embryogenesis. After birth, activates or inhibits angiogenesis,
depending on the context. Inhibits angiogenesis and promotes vascular stability in quiescent vessels, where
endothelial cells have tight contacts. In quiescent vessels, ANGPT1 oligomers recruit TEK to cell-cell contacts,
forming complexes with TEK molecules from adjoining cells, and this leads to preferential activation of
phosphatidylinositol 3-kinase and the AKT1 signaling cascades. In migrating endothelial cells that lack cell-cell
adhesions, ANGT1 recruits TEK to contacts with the extracellular matrix, leading to the formation of focal adhesion
complexes, activation of PTK2/FAK and of the downstream kinases MAPK1/ERK2 and MAPK3/ERK1, and ultimately to the
stimulation of sprouting angiogenesis. Mediates blood vessel maturation/stability. Implicated in endothelial
developmental processes later and distinct from that of VEGF. Appears to play a crucial role in mediating reciprocal
interactions between the endothelium and surrounding matrix and mesenchyme

Gene Wiki entry for ANGPT1 (Angiopoietin 1)


Genomic Views
for ANGPT1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NC_018919.1  NT_008046.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ANGPT1 gene promoter:
         E2F-4   E2F-3a   E2F-5   Lmo2   IRF-1   E2F-2   IRF-2   E2F   E2F-1   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ANGPT1 promoter sequence
   Search SABiosciences Chromatin IP Primers for ANGPT1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ANGPT1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q23.1   Ensembl cytogenetic band:  8q23.1   HGNC cytogenetic band: 8q23.1

ANGPT1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ANGPT1 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M108330:  view genomic region     (about GC identifiers)

Start:
 108,261,710 bp from pter      End:
 108,510,283 bp from pter
Size:
 248,574 bases      Orientation:
 minus strand

Proteins
for ANGPT1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ANGP1_HUMAN, Q15389 (See protein sequence)
Recommended Name: Angiopoietin-1 precursor  
Size: 498 amino acids; 57513 Da
Subunit: Homooligomer. Interacts with TEK/TIE2
Subcellular location: Secreted
Miscellaneous: It may have a potential therapeutic utility since it can be used for specifically targeting tumor
vasculature or for promoting angiogenic processes in certain organs such as an ischemic heart
Sequence caution: Sequence=BAA02793.2; Type=Erroneous initiation;
Secondary accessions: Q5HYA0
Alternative splicing: 2 isoforms:  Q15389-1   Q15389-2   

Explore the universe of human proteins at neXtProt for ANGPT1: NX_Q15389

Post-translational modifications:

  • Glycosylated1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q15389

    • ANGPT1 Protein expression data from MOPED and PaxDb:    About this image 
    ANGPT1 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001137.2  NP_001186788.1  

    ENSEMBL proteins: 
     ENSP00000428340   ENSP00000297450   ENSP00000430750   ENSP00000429349   ENSP00000428908  
    Reactome Protein details: Q15389
    Human Recombinant Protein Products for ANGPT1: 
    EMD Millipore Purified and/or Recombinant ANGPT1 Protein
    R&D Systems Recombinant & Natural Proteins for ANGPT1 (Angiopoietin-1)
    Enzo Life Sciences proteins for ANGPT1
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: ANGPT1
    OriGene Custom Protein Services for ANGPT1 
    GenScript Custom Purified and Recombinant Proteins Services for ANGPT1
    Novus Biologicals ANGPT1 Proteins
    Novus Biologicals ANGPT1 Lysate
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for ANGPT1
    Uscn Proteins for ANGPT1

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IDA8980223
    GO:0005886plasma membrane IDA19424712
    GO:0005902microvillus IDA19424712
    GO:0045121membrane raft IDA19615361

    ANGPT1 for ontologies           About GeneDecksing



    ANGPT1 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of ANGPT1
    R&D Systems Antibodies for ANGPT1 (Angiopoietin-1)
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for ANGPT1 
    GenScript Custom Superior Antibodies Services for ANGPT1
    Novus Biologicals ANGPT1 Antibodies
    Abcam antibodies for ANGPT1 
    Uscn Antibodies for ANGPT1
    ThermoFisher Antibodies for ANGPT1

    Assay Products for ANGPT1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    R&D Systems Flow Cytometry Kits for ANGPT1 (Angiopoietin-1)         (see all)
    GenScript Custom Assay Services for ANGPT1
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for ANGPT1

    Protein Domains /
    Families
    for ANGPT1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ANGPT1 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR020837 Fibrinogen_CS
     IPR014715 Fibrinogen_a/b/g_C_2
     IPR002181 Fibrinogen_a/b/g_C_dom
     IPR014716 Fibrinogen_a/b/g_C_1

    Graphical View of Domain Structure for InterPro Entry Q15389

    ProtoNet protein and cluster: Q15389

    1 Blocks protein family: IPB002181 Fibrinogen

    UniProtKB/Swiss-Prot: ANGP1_HUMAN, Q15389
    Similarity: Contains 1 fibrinogen C-terminal domain


    Function
    for ANGPT1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ANGP1_HUMAN, Q15389
    Function: Binds and activates TEK/TIE2 receptor by inducing its dimerization and tyrosine phosphorylation. Plays an
    important role in the regulation of angiogenesis, endothelial cell survival, proliferation, migration, adhesion and
    cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence. Required for
    normal angiogenesis and heart development during embryogenesis. After birth, activates or inhibits angiogenesis,
    depending on the context. Inhibits angiogenesis and promotes vascular stability in quiescent vessels, where
    endothelial cells have tight contacts. In quiescent vessels, ANGPT1 oligomers recruit TEK to cell-cell contacts,
    forming complexes with TEK molecules from adjoining cells, and this leads to preferential activation of
    phosphatidylinositol 3-kinase and the AKT1 signaling cascades. In migrating endothelial cells that lack cell-cell
    adhesions, ANGT1 recruits TEK to contacts with the extracellular matrix, leading to the formation of focal adhesion
    complexes, activation of PTK2/FAK and of the downstream kinases MAPK1/ERK2 and MAPK3/ERK1, and ultimately to the
    stimulation of sprouting angiogenesis. Mediates blood vessel maturation/stability. Implicated in endothelial
    developmental processes later and distinct from that of VEGF. Appears to play a crucial role in mediating reciprocal
    interactions between the endothelium and surrounding matrix and mesenchyme

         Genatlas biochemistry entry for ANGPT1:
    angiopoietin 1,75kDa,secreted ligand for the vascular endothelial restricted receptor tyrosine kinase TEK,including
    phosphorylation of TEK,widely expressed,involved in late stages of angiogenesis,promoting angiogenic remodeling as
    well as vessel maturation and stabilization

         Summary:  
    During embryonic development, ANGPT1 as signaling molecule is secreted from the following cells: Mural Cells in Splanchnic Mesoderm, Pulmonary Vascular Smooth Muscle Cells in Pulmonary Capillary Plexus

    It affects the following cells: Angioblasts in Embryonic Capillary Plexus, Arterial Endothelial Cells in Pulmonary Capillary Plexus (see all 3).

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding ----
    GO:0030971receptor tyrosine kinase binding IPI8980223
         
    ANGPT1 for ontologies           About GeneDecksing


    Phenotypes:
         7 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Angpt1):
     cardiovascular system  embryogenesis  growth/size  mortality/aging  muscle 
     nervous system  renal/urinary system 

    ANGPT1 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for ANGPT1 

    miRNA
    Products:            		 OriGene 3'-UTR Clone: ANGPT1
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ANGPT1
    8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate ANGPT1 (see all 10):
    hsa-miR-448 hsa-miR-4328 hsa-miR-340 hsa-miR-211 hsa-miR-153 hsa-miR-1244 hsa-miR-96* hsa-miR-204
    SwitchGear 3'UTR luciferase reporter plasmid: ANGPT1 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ANGPT1 (see all 7)
    OriGene shRNA RFP: ANGPT1
    OriGene siRNA: ANGPT1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ANGPT1
    Sirion Biotech Custom design and validation of potent shRNA sequences against ANGPT1 

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for ANGPT1
    Sirion Biotech Customized adenovirus for overexpression of ANGPT1 
    Sirion Biotech Customized adenovirus for potent knockdown of ANGPT1

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ANGPT1 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ANGPT1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): ANGPT1 (NM_001199859)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ANGPT1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ANGPT1 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for ANGPT1
    Search LifeMap BioReagents cell lines for ANGPT1
    Sirion Biotech Customized stable knockdown cell line services for ANGPT1 
    Sirion Biotech Customized inducible knockdown cell line services for ANGPT1
    Sirion Biotech Customized stable overexpressing cell line services for ANGPT1
    Sirion Biotech Customized inducible overexpressing cell line services for ANGPT1

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANGPT1


    Pathways & Interactions
    for ANGPT1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/12 super-pathways (see all 12) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1PEDF Induced Signaling
    8/11 pathways (see all 11)
    		PEDF Induced Signaling1.00
    		STAT3 Pathway0.47
    		MIF Mediated Glucocorticoid Regulation0.73
    		Endothelin-1 Signaling Pathway0.44
    		MIF Regulation of Innate Immune Cells0.71
    		NFAT Signaling and Lymphocyte Interactions0.37
    		IL-6 Pathway0.61
    		PGC1Alpha Pathway0.33
    2TGF-Beta Pathway
    		TGF-Beta Pathway1.00
    		JNK Pathway0.50
    		MAPK Family Pathway0.60
    		Regulation of eIF4 and p70S6K0.43
    		JAK-STAT Pathway0.57
    		SOCS Pathway0.29
    3Development_PDGF signaling via STATs and NF-kB
    		Development_Angiopoietin - Tie2 signaling0.38
    		Angiopoietin-TIE2 Signaling0.13
    		Development Angiopoietin - Tie2 signaling0.38
    		Angiopoietin receptor Tie2-mediated signaling0.11
    4Akt Signaling
    		Akt Signaling1.00
    		Tec Kinases Signaling0.55
    		p38 Signaling0.60
    5Rho Family GTPases
    		Rho Family GTPases1.00
    		Molecular Mechanisms of Cancer0.51
    		ERK Signaling0.61

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    2 EMD Millipore Pathways for ANGPT1
        Development Angiopoietin - Tie2 signaling
    G-protein signaling H-RAS regulation pathway

    5/26 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for ANGPT1 (see all 26)
        Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    NFAT Signaling and Lymphocyte Interactions
    JNK Pathway

    2 GeneGo (Thomson Reuters) Pathways for ANGPT1
        G-protein signaling H-RAS regulation pathway
    Development Angiopoietin - Tie2 signaling

    2 BioSystems Pathways for ANGPT1 
        Angiogenesis
    Angiopoietin receptor Tie2-mediated signaling

    3        Reactome Pathways for ANGPT1
        Hemostasis
    Cell surface interactions at the vascular wall
    Tie2 Signaling


    1         Kegg Pathway  (Kegg details for ANGPT1):
        Rheumatoid arthritis


    ANGPT1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ANGPT1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/35 Interacting proteins for ANGPT1 (Q153893 ENSP000002974504) via UniProtKB, MINT, STRING, and/or I2D (see all 35)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TEKQ027633, ENSP000003839774I2D: score=4 STRING: ENSP00000383977
    ANGPT2O151233, ENSP000003148974I2D: score=1 STRING: ENSP00000314897
    ITGA5P086483, ENSP000002933794I2D: score=2 STRING: ENSP00000293379
    CRKENSP000003005744STRING: ENSP00000300574
    DOK2ENSP000002764204STRING: ENSP00000276420
    About this table

    Gene Ontology (GO): 5/39 biological process terms (GO ID links to tree view) (see all 39):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis ----
    GO:0001541ovarian follicle development ----
    GO:0001666response to hypoxia ----
    GO:0001701in utero embryonic development IEA--
    GO:0001936NOT regulation of endothelial cell proliferation IDA8980223

    ANGPT1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for ANGPT1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ANGPT1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ANGPT1
    10/43 Novoseek chemical compound relationships for ANGPT1 gene (see all 43)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    vegf 88.9 788 14584044 (8), 19564638 (8), 19160387 (7), 15367176 (7) (see all 99)
    tyrosine 63.6 109 18848573 (3), 17595127 (3), 10706866 (2), 8980223 (2) (see all 65)
    ameroid 52.8 1 16547766 (1)
    matrigel 49 4 16754788 (1), 20098680 (1), 15501241 (1), 12759249 (1)
    ly294002 45.7 3 19028450 (1), 15763944 (1), 12514118 (1)
    wortmannin 42.5 3 16447257 (1), 19379779 (1), 16826573 (1)
    phosphatidylinositol 35.3 20 17599743 (3), 11729102 (3), 16000309 (3), 16372478 (2) (see all 9)
    tween 28.6 4 16363251 (1), 16164572 (1)
    gelfoam 17.6 2 12810673 (2)
    progestin 16.1 3 10587365 (1), 12213726 (1)

    Search CenterWatch for drugs/clinical trials and news about ANGPT1 / ANGP1 

    Transcripts
    for ANGPT1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ANGPT1 gene (3 alternative transcripts): 
    NM_001146.3  NM_001199859.1  NM_139290.1  

    Unigene Cluster for ANGPT1:

    Angiopoietin 1
    Hs.369675  [show with all ESTs]
    Unigene Representative Sequence: BX648814
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000517746(uc011lhv.2) ENST00000297450(uc003ymn.3 uc003ymo.3)
    ENST00000520734 ENST00000520052 ENST00000518386 ENST00000521950(uc003ymp.4)
    ENST00000522400 ENST00000520033

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ANGPT1
    8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate ANGPT1 (see all 10):
    hsa-miR-448 hsa-miR-4328 hsa-miR-340 hsa-miR-211 hsa-miR-153 hsa-miR-1244 hsa-miR-96* hsa-miR-204
    SwitchGear 3'UTR luciferase reporter plasmid: ANGPT1 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ANGPT1 (see all 7)
    OriGene shRNA RFP: ANGPT1
    OriGene siRNA: ANGPT1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ANGPT1
    Sirion Biotech Custom design and validation of potent shRNA sequences against ANGPT1 
    Clone
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    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ANGPT1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): ANGPT1 (NM_001199859)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ANGPT1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ANGPT1 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ANGPT1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ANGPT1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ANGPT1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ANGPT1

    Additional cDNA sequence: 

    AB084454.1 AK300319.1 AK304717.1 AY121504.1 AY124380.1 BC029406.1 BC152411.1 BC152419.1 
    BX648814.1 D13628.2 U83508.1 

    7 DOTS entries:

    DT.409144  DT.92048735  DT.100655583  DT.91826443  DT.95268809  DT.95268811  DT.95268810 

    24/75 AceView cDNA sequences (see all 75):

    CB959296 AA903299 AL700970 NM_001146 AI753541 AW296269 AY124380 BU627306 
    BF195841 BF224438 BU625006 U83508 AB084454 AY121504 AI658562 AW044503 
    CA391291 NM_139290 BF435199 D13628 CA442002 CA394153 BX504259 AI754490 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for ANGPT1 (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b · 10c · 10d ^ 11 ^ 12a · 12b · 12c · 12d
    SP1:                    -     -                 -                                   -                             -     -                                 
    SP2:                    -     -                 -                                   -                             -     -                                 
    SP3:                                                                                -           -     -           -     -                                 
    SP4:                                                                                -                                                                     
    SP5:                                                                    -     -     -                 -     -     -     -                                 


    ECgene alternative splicing isoforms for ANGPT1

    Expression
    for ANGPT1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ANGPT1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGGTTTCTAT
    ANGPT1 Expression
    About this image

    ANGPT1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    8 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BrainBlood Brain BarrierPericytesPericytes
    Neural TubePerineural capillary PlexusAngioblastsBlood Brain Barrier, Endothelium
    Extraembryonic MesodermExtraembryonic MesodermExtraembryonic Mural CellsExtraembryonic Tissues
    Lateral Plate MesodermSplanchnic MesodermMural CellsPericytes, Smooth Muscle
    Lateral Plate MesodermSplanchnic MesodermPericytesPericytes
    LungPulmonary Capillary PlexusPulmonary Vascular Smooth Muscle CellsLung, Smooth Muscle
    PlacentaChorionic VillusVillous Cytotrophoblast CellsExtraembryonic Tissues, Placenta
    PlacentaExtravillous Cytotrophoblast LayerExtravillous Cytotrophoblast CellsExtraembryonic Tissues, Placenta
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 3 LifeMap Cells 
    NameCategory
    PureStem™ endothelial progenitor RP1-MV2-18 (Embryonic Progenitor Cell)Endothelium
    PureStem™ progenitor SK17 (Embryonic Progenitor Cell)
    Mesendoderm-like cells (Generation of mesend...)

    See ANGPT1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ANGPT1

    SOURCE GeneReport for Unigene cluster: Hs.369675
        SABiosciences Expression via Pathway-Focused PCR Arrays including ANGPT1 (see all 6): 
              Endothelial Cell Biology in human mouse rat
              Angiogenic Growth Factors in human mouse rat
              Wound Healing in human mouse rat
              Cancer PathwayFinder in human mouse rat
              Angiogenesis in human mouse rat

    Primer
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    In Situ
    Assay Products:     
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    Orthologs
    for ANGPT1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for ANGPT1 gene from 4/13 species (see all 13)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves ANGPT11 angiopoietin 1 83.9(n)
    91.75(a)    		   395129  NM_001199447.1  NP_001186376.1 
    lizard
    (Anolis carolinensis)    		 Reptilia ANGPT16
    		 --
    		 90(a)
    		 1 ↔ 1
    		 4(11700040-11769195)
    zebrafish
    (Danio rerio)    		 Actinopterygii angpt12 angiopoietin 1 74.33(n)   114407  AF379602.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG103593   -- 41(a)   63E5   --


    ENSEMBL Gene Tree for ANGPT1 (if available)
    TreeFam Gene Tree for ANGPT1 (if available) 

    Paralogs
    for ANGPT1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ANGPT1 gene
    FGL22  ANGPT42  FGA2  FGG2  ANGPTL62  ANGPTL22  ANGPTL42  ANGPTL32  
    ANGPTL12  ANGPTL72  FGB2  ANGPT22  FGL12  
    18/21 SIMAP similar genes for ANGPT1 using alignment to 4 protein entries:     ANGP1_HUMAN (see all proteins) (see all similar genes):
    AngA    ANGPT2    ANGPT4    FCN1    FCN3    FCN2
    ANGPTL7    ANGPTL1    ANGPTL2    TNXB    ANGPTL4    MFAP4
    TNC    FGL1    LFIRE1    ANGPTL6    FIBCD1    FGL2

    ANGPT1 for paralogs           About GeneDecksing



    Genomic Variants
    for ANGPT1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/4383 NCBI SNPs in ANGPT1 are shown (see all 4383)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 8 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1161792301,2
    		C,F--103581381(+) GGCAAT/CAGGAG 2 -- ds50011Minor allele frequency- C:0.03WA 118
    rs101128251,2
    		C,F,H--103581701(+) GAAAGT/GTGTTC 2 -- ds50015Minor allele frequency- G:0.01NS NA 696
    rs455174371,2
    		F--103581911(-) ATGTGG/CAATTT 4 -- ut311Minor allele frequency- C:0.41NA 46
    rs1121361021,2
    		C--103581942(+) CAATTAAATG/- 
                AAAAG     		2 -- ut311Minor allele frequency- -:0.50CSA 2
    rs456145421,2
    		F--103581943(-) TATTA-/CATTT 
                AATTG     		4 -- ut311Minor allele frequency- CATTT:0.41NA 46
    rs414159451,2
    		C,F--103582365(-) TCAAGT/GCTTTT 2 -- ut312Minor allele frequency- G:0.03NA WA 166
    rs414215481,2
    		C--103582477(-) CAATAC/ACAGTT 2 -- ut311Minor allele frequency- A:0.02NA 48
    rs413642481,2
    		C,F--103582485(-) CAAGGT/CAGCAA 2 -- ut313Minor allele frequency- C:0.09NA WA 286
    rs413431481,2
    		C--103582587(-) GTTATG/AACAGT 2 -- ut311Minor allele frequency- A:0.02NA 48
    rs455327341,2
    		F--103582772(-) AAAATA/TATATA 4 -- ut311Minor allele frequency- T:0.42NA 48

    HapMap Linkage Disequilibrium report for ANGPT1 (108261710 - 108510283 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 12 variations for ANGPT1
         5 CNVs: 6653 59442 95624 65227 100453
         7 Indels: 43129 62836 41119 41118 41397 47428 60725
    Human Gene Mutation Database (HGMD): ANGPT1

    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for ANGPT1

    Disorders / Diseases
    for ANGPT1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ANGPT1 for disorders           About GeneDecksing

    OMIM gene information: 601667    OMIM disorders: --

    20/112 diseases for ANGPT1 (see all 112):    About MalaCards
    proliferative diabetic retinopathy    non-small cell lung carcinoma    myocardial infarction    acute myocardial infarction
    malignant pleural mesothelioma    squamous cell carcinoma    diabetic retinopathy    congestive heart failure
    sickle cell disease    gastrointestinal stromal tumor    renal clear cell carcinoma    gingival overgrowth
    lipodermatosclerosis    venous malformations    laryngeal squamous cell carcinoma    chorioangioma
    funisitis    oral squamous cell carcinoma    bronchopulmonary dysplasia    malignant glioma

    2 diseases from the University of Copenhagen DISEASES database for ANGPT1:
    Vascular disease     Cancer

    10/85 Novoseek disease relationships for ANGPT1 gene (see all 85)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    neovascularization 76.6 31 9710115 (4), 17376288 (2), 9808608 (1), 11677194 (1) (see all 20)
    tumors 48.5 204 19018775 (7), 12810673 (6), 19487284 (5), 11245414 (5) (see all 81)
    metastasis 35 16 19487284 (3), 19916173 (3), 16465407 (2), 14607656 (1) (see all 8)
    uterine bleeding 32.7 1 20233519 (1)
    acute respiratory distress 31.7 2 19543148 (1), 17322110 (1)
    preeclampsia 30.5 10 19875484 (2), 16363251 (1), 17409768 (1), 19478794 (1) (see all 6)
    inflammation 30.5 37 16741035 (3), 17322110 (3), 19772173 (2), 17560831 (2) (see all 23)
    hypertension pulmonary 25.5 21 11436038 (4), 15678035 (3), 14759414 (3), 12571257 (2) (see all 8)
    proliferative diabetic retinopathy 25.2 1 15774928 (1)
    respiratory distress syndrome 24.6 2 19543148 (1), 17322110 (1)

    Human Genome Epidemiology (HuGE) Navigator: ANGPT1 (7 documents)

    Export disorders for ANGPT1 gene to outside databases

    Publications
    for ANGPT1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ANGPT1 gene, integrated from 9 sources (see all 615):
    (articles sorted by number of sources associating them with ANGPT1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning. (PubMed id 8980223)1, 2, 9 Davis S....Yancopoulos G.D. (1996)
    2. Biological characterization of angiopoietin-3 and angiopoietin-4. (PubMed id 15284220)1, 2, 9 Lee H.J....Koh G.Y. (2004)
    3. Differential function of Tie2 at cell-cell contacts and cell-substratum contacts regulated by angiopoietin-1. (PubMed id 18425120)1, 2 Fukuhara S....Mochizuki N. (2008)
    4. Angiopoietin-1 and angiopoietin-2 share the same binding domains in the Tie-2 receptor involving the first Ig-like loop and the epidermal growth factor-like repeats. (PubMed id 12427764)1, 2 Fiedler U....Augustin H.G. (2003)
    5. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (2002)
    6. Endothelial Tie2/Tek ligands angiopoietin-1 (ANGPT1) and angiopoietin-2 (ANGPT2): regional localization of the human genes to 8q22.3-q23 and 8p23. (PubMed id 9545648)1, 3 Cheung A.H....Marsden P.A. (1998)
    7. Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis. (PubMed id 9204896)1, 2 Maisonpierre P.C.... Yancopoulos G.D. (1997)
    8. Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1. (PubMed id 7584026)1, 2 Nomura N.... Tabata S. (1994)
    9. Angiopoietin-1 inhibits vascular permeability, angiogenesis, and growth of hepatic colon cancer tumors. (PubMed id 12810673)1, 9 Stoeltzing O....Ellis L.M. (2003)
    10. Oligomerization and multimerization are critical for angiopoietin-1 to bind and phosphorylate Tie2. (PubMed id 15769741)1, 9 Kim K.T....Koh G.Y. (2005)

    External Searches for ANGPT1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing ANGPT1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 284 HGNC: 484 AceView: ANGPT1 Ensembl:ENSG00000154188 euGenes: HUgn284
    ECgene: ANGPT1 Kegg: 284 H-InvDB: ANGPT1

    Other Databases showing ANGPT1 gene

    (According to HUGE)
    About This Section
    HUGE: KIAA0003

    Specialized Databases showing ANGPT1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ANGPT1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ANGPT1 Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/Angiopoietin

    Intellectual Property
    for ANGPT1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ANGPT1 gene:
    Search GeneIP for patents involving ANGPT1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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