Aliases for ANGPT1 Gene
Aliases for ANGPT1 Gene
External Ids for ANGPT1 Gene
- HGNC: 484
- Entrez Gene: 284
- Ensembl: ENSG00000154188
- OMIM: 601667
- UniProtKB: Q15389
Previous GeneCards Identifiers for ANGPT1 Gene
- GC08M108328
- GC08M107930
- GC08M108218
- GC08M108330
- GC08M103581
Summaries for ANGPT1 Gene
-
This gene encodes a secreted glycoprotein that belongs to the angiopoietin family. Members of this family play important roles in vascular development and angiogenesis. All angiopoietins bind with similar affinity to an endothelial cell-specific tyrosine-protein kinase receptor. The protein encoded by this gene is a secreted glycoprotein that activates the receptor by inducing its tyrosine phosphorylation. It plays a critical role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme and inhibits endothelial permeability. The protein also contributes to blood vessel maturation and stability, and may be involved in early development of the heart. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Sep 2015]
GeneCards Summary for ANGPT1 Gene
ANGPT1 (Angiopoietin 1) is a Protein Coding gene. Diseases associated with ANGPT1 include Pyogenic Granuloma and Twin-To-Twin Transfusion Syndrome. Among its related pathways are RET signaling and PEDF Induced Signaling. GO annotations related to this gene include receptor binding and receptor tyrosine kinase binding. An important paralog of this gene is ANGPT2.
UniProtKB/Swiss-Prot for ANGPT1 Gene
-
Binds and activates TEK/TIE2 receptor by inducing its dimerization and tyrosine phosphorylation. Plays an important role in the regulation of angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence. Required for normal angiogenesis and heart development during embryogenesis. After birth, activates or inhibits angiogenesis, depending on the context. Inhibits angiogenesis and promotes vascular stability in quiescent vessels, where endothelial cells have tight contacts. In quiescent vessels, ANGPT1 oligomers recruit TEK to cell-cell contacts, forming complexes with TEK molecules from adjoining cells, and this leads to preferential activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascades. In migrating endothelial cells that lack cell-cell adhesions, ANGT1 recruits TEK to contacts with the extracellular matrix, leading to the formation of focal adhesion complexes, activation of PTK2/FAK and of the downstream kinases MAPK1/ERK2 and MAPK3/ERK1, and ultimately to the stimulation of sprouting angiogenesis. Mediates blood vessel maturation/stability. Implicated in endothelial developmental processes later and distinct from that of VEGF. Appears to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANGPT1 Gene
Genomics for ANGPT1 Gene
Regulatory Elements for ANGPT1 Gene
Enhancers for ANGPT1 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH08G107331 | 1.3 | Ensembl ENCODE dbSUPER | 10.4 | +165.9 | 165851 | 1.3 | CTCF GTF2E2 ZNF316 FOXK2 ZNF584 MAFK IKZF2 ZNF639 ZNF197 MTA2 | ANGPT1 GC08M107314 GC08M107369 |
| GH08G107494 | 1.4 | FANTOM5 ENCODE dbSUPER | 8.7 | +1.6 | 1631 | 4.4 | CBX3 ATF1 RAD21 GATA2 FOS ZNF654 REST PRDM6 GLIS1 HMBOX1 | ANGPT1 GC08M107369 |
| GH08G107334 | 0.9 | dbSUPER | 10.4 | +162.3 | 162301 | 3.3 | HDAC1 ATF1 ARNT NFRKB CHAMP1 GATA2 CEBPB ELF4 POLR2H MEF2D | ANGPT1 GC08M107314 GC08M107369 |
| GH08G107425 | 0.4 | ENCODE | 18.6 | +72.0 | 71962 | 1.2 | HLF | ANGPT1 GC08M107369 |
| GH08G107485 | 1 | Ensembl ENCODE dbSUPER | 7.1 | +11.7 | 11738 | 2.2 | GATA2 POU5F1 ZMYM3 IRF1 NR2F2 | ANGPT1 GC08M107369 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around ANGPT1 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for ANGPT1 Gene
- Chromosome:
- 8
- Start:
- 107,249,482 bp from pter
- End:
- 107,498,055 bp from pter
- Size:
- 248,574 bases
- Orientation:
- Minus strand
Genomic View for ANGPT1 Gene
Genes around ANGPT1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 8q23.1 by Ensembl
- 8q23.1 by Entrez Gene
- 8q23.1 by HGNC
ANGPT1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ANGPT1 Gene
Proteins for ANGPT1 Gene
-
Protein details for ANGPT1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q15389-ANGP1_HUMAN
- Recommended name:
- Angiopoietin-1
- Protein Accession:
- Q15389
- Q5HYA0
Protein attributes for ANGPT1 Gene
- Size:
- 498 amino acids
- Molecular mass:
- 57513 Da
- Quaternary structure:
-
- Homooligomer. Interacts with TEK/TIE2.
- Miscellaneous:
-
- It may have a potential therapeutic utility since it can be used for specifically targeting tumor vasculature or for promoting angiogenic processes in certain organs such as an ischemic heart.
- SequenceCaution:
-
- Sequence=BAA02793.2; Type=Erroneous initiation; Evidence={ECO:0000305};
Protein Expression for ANGPT1 Gene
Post-translational modifications for ANGPT1 Gene
- Glycosylated.
- Glycosylation at posLast=9292, posLast=122122, posLast=154154, Asn243, and posLast=295295
- Modification sites at PhosphoSitePlus
Other Protein References for ANGPT1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for ANGPT1
- R&D Systems Antibodies for ANGPT1 (Angiopoietin-1)
-
Custom Antibody ServicesOriGene Antibodies for ANGPT1
- Novus Biologicals Antibodies for ANGPT1
-
Abcam antibodies for ANGPT1
-
Cloud-Clone Corp. Antibodies for ANGPT1
- Invitrogen Antibodies for ANGPT1
- antibodies-online Antibodies for ANGPT1: See all 167
- GeneTex ANGPT1 antibody for ANGPT1
Protein Products
- EMD Millipore Purified and/or Recombinant ANGPT1 Protein
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-
OriGene Purified Proteins for ANGPT1
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- Sino Biological Recombinant Proteins for ANGPT1
- ProSpec Recombinant Proteins for ANGPT1
-
Cloud-Clone Corp. Proteins for ANGPT1
- antibodies-online Proteins for ANGPT1: See all 47
- Search antibodies-online for peptides
- GeneTex Proteins for ANGPT1
-
ProSci Proteins for ANGPT1
-
Abcam proteins for ANGPT1
Assay Products
-
Custom Assay ServicesOriGene ELISA Kits for ANGPT1
- R&D Systems Proteome Profiler Antibody Arrays, Luminex Assays, ELISAs, and other biochemical assays for ANGPT1 (Angiopoietin-1)
- antibodies-online Kits for ANGPT1: See all 98
No data available for DME Specific Peptides for ANGPT1 Gene
Domains & Families for ANGPT1 Gene
Gene Families for ANGPT1 Gene
Protein Domains for ANGPT1 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for ANGPT1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for ANGPT1 Gene
Function for ANGPT1 Gene
Molecular function for ANGPT1 Gene
- GENATLAS Biochemistry:
- angiopoietin 1,75kDa,secreted ligand for the vascular endothelial restricted receptor tyrosine kinase TEK,including phosphorylation of TEK,widely expressed,involved in late stages of angiogenesis,promoting angiogenic remodeling as well as vessel maturation and stabilization
- UniProtKB/Swiss-Prot Function:
- Binds and activates TEK/TIE2 receptor by inducing its dimerization and tyrosine phosphorylation. Plays an important role in the regulation of angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence. Required for normal angiogenesis and heart development during embryogenesis. After birth, activates or inhibits angiogenesis, depending on the context. Inhibits angiogenesis and promotes vascular stability in quiescent vessels, where endothelial cells have tight contacts. In quiescent vessels, ANGPT1 oligomers recruit TEK to cell-cell contacts, forming complexes with TEK molecules from adjoining cells, and this leads to preferential activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascades. In migrating endothelial cells that lack cell-cell adhesions, ANGT1 recruits TEK to contacts with the extracellular matrix, leading to the formation of focal adhesion complexes, activation of PTK2/FAK and of the downstream kinases MAPK1/ERK2 and MAPK3/ERK1, and ultimately to the stimulation of sprouting angiogenesis. Mediates blood vessel maturation/stability. Implicated in endothelial developmental processes later and distinct from that of VEGF. Appears to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme.
LifeMap Function Summary for ANGPT1 Gene
During embryonic development, ANGPT1 as signaling molecule is secreted from the following cells
- Lateral Plate Mesoderm
- Lung
- Head Mesenchyme
It affects the following cells:
- Lateral Plate Mesoderm
- Lung
- Blood
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005088 | Ras guanyl-nucleotide exchange factor activity | TAS | -- |
| GO:0005102 | receptor binding | IEA | -- |
| GO:0030971 | receptor tyrosine kinase binding | IEA,IPI | 8980223 |
Phenotypes for ANGPT1 Gene
- MGI mutant phenotypes for ANGPT1:
- inferred from 5 alleles
- GenomeRNAi human phenotypes for ANGPT1:
Animal Models for ANGPT1 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for ANGPT1
-
-
ViGene Biosciences lentiviral particle packaged cDNA for ANGPT1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for ANGPT1 gene
- Search ViGene Biosciences for ANGPT1
CRISPR Products
-
OriGene CRISPR knockouts for ANGPT1
-
Santa Cruz Biotechnology (SCBT) CRISPR for ANGPT1
- GenScript: Design CRISPR guide RNA sequences for ANGPT1
miRNA for ANGPT1 Gene
- miRTarBase miRNAs that target ANGPT1
miRNA Products
- Search ViGene Biosciences for ANGPT1
Inhibitory RNA Products
- Origene RNAi, shRNA, and siRNA products in human, mouse, rat for ANGPT1
- Browse OriGene Inhibitory RNA Products For ANGPT1
-
ViGene Biosciences ready-to-package AAV shRNAs for ANGPT1 gene
Clone Products
- Sino Biological Human cDNA Clone for ANGPT1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for ANGPT1
- VectorBuilder custom plasmid, inducible vectors for ANGPT1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ANGPT1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for ANGPT1
-
ViGene Biosciences adenoviral particle packaged cDNA for ANGPT1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for ANGPT1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for ANGPT1 gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ANGPT1 Gene
Localization for ANGPT1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ANGPT1 Gene
- Secreted.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
| cytoskeleton | 2 |
| endoplasmic reticulum | 2 |
| mitochondrion | 1 |
| peroxisome | 1 |
| nucleus | 1 |
| cytosol | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | TAS | -- |
| GO:0005615 | extracellular space | IDA | 8980223 |
| GO:0005622 | intracellular | IEA | -- |
| GO:0005886 | plasma membrane | IDA | 19424712 |
| GO:0005902 | microvillus | IDA | 19424712 |
Pathways & Interactions for ANGPT1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | RET signaling |
.92
|
.92
|
| 2 | PEDF Induced Signaling |
.61
|
.47
|
| 3 | TGF-Beta Pathway |
.60
.57
|
.51
.40
|
| 4 | Immune response IL-23 signaling pathway | ||
| 5 | Akt Signaling |
.60
.60
|
|
Pathways by source for ANGPT1 Gene
4 BioSystems pathways for ANGPT1 Gene
49 Reactome pathways for ANGPT1 Gene
5 KEGG pathways for ANGPT1 Gene
2 GeneGo (Thomson Reuters) pathways for ANGPT1 Gene
26 Qiagen pathways for ANGPT1 Gene
Interacting Proteins for ANGPT1 Gene
Selected Interacting proteins:
ENSP00000428340
Q15389-ANGP1_HUMAN
for ANGPT1 Gene via
STRING
IID
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000165 | MAPK cascade | TAS | -- |
| GO:0001525 | angiogenesis | IEA | -- |
| GO:0001701 | in utero embryonic development | IEA | -- |
| GO:0001933 | negative regulation of protein phosphorylation | IEA | -- |
| GO:0001936 | NOT regulation of endothelial cell proliferation | IDA | 8980223 |
Transcripts for ANGPT1 Gene
mRNA/cDNA for ANGPT1 Gene
- (4) REFSEQ mRNAs :
- (11) Additional mRNA sequences :
- (75) Selected AceView cDNA sequences:
- (8) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for ANGPT1
-
Santa Cruz Biotechnology (SCBT) CRISPR for ANGPT1
- GenScript: Design CRISPR guide RNA sequences for ANGPT1
miRNA Products
- Search ViGene Biosciences for ANGPT1
Inhibitory RNA Products
- Origene RNAi, shRNA, and siRNA products in human, mouse, rat for ANGPT1
- Browse OriGene Inhibitory RNA Products For ANGPT1
-
ViGene Biosciences ready-to-package AAV shRNAs for ANGPT1 gene
Clone Products
- Sino Biological Human cDNA Clone for ANGPT1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for ANGPT1
- VectorBuilder custom plasmid, inducible vectors for ANGPT1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ANGPT1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9a | · | 9b | · | 9c | ^ | 10a | · | 10b | · | 10c | · | 10d | ^ | 11 | ^ | 12a | · | 12b | · | 12c | · | 12d |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - |
Expression for ANGPT1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Brain (Nervous System)
- Angioblasts Perineural Capillary Plexus
- Pericytes Blood Brain Barrier
- Neural stem cell line (CTX0E03)
-
Endothelium (Cardiovascular System)
- Angioblasts Perineural Capillary Plexus
- MultiGeneAngio, transduced vein-derived endothelial cells
- Blood (Hematopoietic System)
-
Neural Tube (Nervous System)
- Angioblasts Perineural Capillary Plexus
- Bone (Muscoskeletal System)
- Mesenchymal Stem Cells
mRNA differential expression in normal tissues according to GTEx for ANGPT1 Gene
This gene is overexpressed in Artery - Tibial (x5.9).
This gene is overexpressed in Peripheral blood mononuclear cells (25.5), Serum (20.2), CD8 Tcells (16.7), and Platelet (6.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ANGPT1 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of ANGPT1 Gene:
ANGPT1SOURCE GeneReport for Unigene cluster for ANGPT1 Gene:
Hs.369675Evidence on tissue expression from TISSUES for ANGPT1 Gene
- Lung(4.5)
- Bone marrow(4.4)
- Liver(4.3)
- Intestine(4.2)
- Heart(3.2)
- Blood(2.7)
- Muscle(2.7)
- Kidney(2.1)
- Nervous system(2.1)
Primer Products
-
OriGene qPCR primer pairs for ANGPT1
-
OriGene qPCR primer pairs and template standards for ANGPT1
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ANGPT1 Gene
Orthologs for ANGPT1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ANGPT1 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | ANGPT1 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | ANGPT1 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Angpt1 34 16 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | ANGPT1 35 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Angpt1 34 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | ANGPT1 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | ANG-1 35 |
|
OneToOne | |
| ANGPT1 34 |
|
||||
| lizard (Anolis carolinensis) |
Reptilia | ANGPT1 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | angpt1 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | angpt1 34 35 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | CG10359 36 |
|
|
- Species where no ortholog for ANGPT1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for ANGPT1 Gene
Paralogs for ANGPT1 Gene
(19) SIMAP similar genes for ANGPT1 Gene using alignment to 4 proteins:
Variants for ANGPT1 Gene
| SNP ID | Clin | Chr 08 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000008147 | -- | 107,438,640(+) | TTATA(G/T)AAATG | intron-variant | |
| rs1000024132 | -- | 107,384,238(+) | TTGGC(A/G)TGGTT | intron-variant | |
| rs1000038760 | -- | 107,431,995(+) | CTCAA(C/T)TGAGC | intron-variant | |
| rs1000079926 | -- | 107,333,486(+) | ACCTA(C/T)ATTAC | intron-variant | |
| rs1000092211 | -- | 107,312,955(+) | GGATA(A/G)TTAAT | intron-variant |
Residual Variation Intolerance Score:
19.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.72;
32.74% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for ANGPT1 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANGPT1 Gene
Disorders for ANGPT1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| pyogenic granuloma |
|
|
| twin-to-twin transfusion syndrome |
|
|
| epileptic encephalopathy, childhood-onset |
|
|
| chronic myocardial ischemia |
|
|
| funisitis |
|
|
Search ANGPT1 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for ANGPT1
No data available for UniProtKB/Swiss-Prot and Genatlas for ANGPT1 Gene
Publications for ANGPT1 Gene
- A functional variant in the 3'-UTR of angiopoietin-1 might reduce stroke risk by interfering with the binding efficiency of microRNA 211. (PMID: 20378606) Chen J. … Hui R. (Hum. Mol. Genet. 2010) 3 22 46 64
- Biological characterization of angiopoietin-3 and angiopoietin-4. (PMID: 15284220) Lee H.J. … Koh G.Y. (FASEB J. 2004) 3 4 22 64
- Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning. (PMID: 8980223) Davis S. … Yancopoulos G.D. (Cell 1996) 3 4 22 64
- Genetic risk factors for hepatopulmonary syndrome in patients with advanced liver disease. (PMID: 20346360) Roberts K.E. … Fallon M.B. (Gastroenterology 2010) 3 46 64
- Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol? (PMID: 20602615) RuaA+o G. … Wu A.H. (Pharmacogenomics 2010) 3 46 64
Products for ANGPT1 Gene
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- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for ANGPT1
- EMD Millipore Purified and/or Recombinant ANGPT1 Protein
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- Custom Antibody ServicesOriGene Antibodies for ANGPT1
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- GenScript Custom Purified and Recombinant Proteins Services for ANGPT1
- GenScript Custom Assay Services for ANGPT1
- GenScript Custom overexpressing Cell Line Services for ANGPT1
- GenScript: Design CRISPR guide RNA sequences for ANGPT1
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for ANGPT1
- Sino Biological Human cDNA Clone for ANGPT1
- Sino Biological Recombinant Proteins for ANGPT1
- Sino Biological Cell Lysates for ANGPT1
- Sino Biological Antibodies
- Sino Biological ELISA Kits and Pair Sets
- Sino Biological Cell Lysates
- Sino Biological qPCR Primers
- Sino Biological CRO Services for Proteins, Antibodies and Genes
- Sino Biological Transfection Reagents
- Novus Biologicals Antibodies for ANGPT1
- Novus Biologicals proteins and lysates for ANGPT1
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Abcam antibodies for ANGPT1
- Abcam proteins for ANGPT1
- Search for Assays for ANGPT1 at Abcam
- Find your target
- Search knockout validated antibodies
- Browse monoclonal antibodies
- ProSpec Recombinant Proteins for ANGPT1
- Cloud-Clone Corp. Antibodies for ANGPT1
- Cloud-Clone Corp. Proteins for ANGPT1
- Addgene plasmids for ANGPT1
- antibodies-online Antibodies for ANGPT1: See all 167
- antibodies-online Kits for ANGPT1: See all 98
- antibodies-online Proteins for ANGPT1: See all 47
- Search antibodies-online for peptides
- GeneTex ANGPT1 antibody for ANGPT1
- GeneTex Proteins for ANGPT1
- ViGene Biosciences adenoviral particle packaged cDNA for ANGPT1 gene
- ViGene Biosciences lentiviral particle packaged cDNA for ANGPT1 gene
- ViGene Biosciences ready-to-package AAV shRNAs for ANGPT1 gene
- Search ViGene Biosciences for ANGPT1
- Horizon Cell Lines for ANGPT1
- Cyagen custom Knockout/knockin (KOKI) mouse models for ANGPT1
- VectorBuilder custom plasmid, inducible vectors for ANGPT1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ANGPT1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for ANGPT1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer