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ANGPT1 Gene

protein-coding GIFtS: 66

GC08M108330

angiopoietin 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
AGP1 ^²
AGPT ^²
ANG-1 ^³
ANG1 ^², ⁵
Ang1 ^¹
KIAA0003 ^¹, ³

Descriptions
angiopoietin 1 ^²

External Ids
HGNC: 484¹
Entrez Gene: 284²
UniProtKB: Q15389³
Ensembl: ENSG00000154188⁷

Search outside databases for aliases for ANGPT1 gene

Previous GC identifers: GC08M107246 GC08M108328 GC08M107930 GC08M108218

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for ANGPT1:

Angiopoietins are proteins with important roles in vascular development and angiogenesis. All

angiopoietins bind with similar affinity to an endothelial cell-specific tyrosine-protein kinase

receptor. The protein encoded by this gene is a secreted glycoprotein that activates the receptor

by inducing its tyrosine phosphorylation. It plays a critical role in mediating reciprocal

interactions between the endothelium and surrounding matrix and mesenchyme. The protein also

contributes to blood vessel maturation and stability, and may be involved in early development of

the heart. [provided by RefSeq]

UniProtKB/Swiss-Prot: ANGP1_HUMAN, Q15389

Function: Binds and activates TIE2 receptor by inducing its tyrosine phosphorylation. Implicated in

endothelial developmental processes later and distinct from that of VEGF. Appears to play a

crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix

and mesenchyme. Mediates blood vessel maturation/stability. It may play an important role in the

heart early development

Gene Wiki entry for ANGPT1 (Angiopoietin_1)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the ANGPT1 gene

Entrez Gene cytogenetic band: 8q22.3-q23 Ensembl cytogenetic band: 8q23.1 HGNC cytogenetic band: 8q23.1

ANGPT1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 8 GeneLoc Exon Structure

GeneLoc location for GC08M108330: (about GC identifiers)

Start:	108,330,886 bp from pter
End:	108,579,459 bp from pter
Size:	248,574 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000008.9 NT_008046.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: ANGP1_HUMAN, Q15389 (See protein sequence)

Recommended Name: Angiopoietin-1 precursor

Size: 498 amino acids; 57513 Da

Subcellular location: Secreted

Miscellaneous: It may have a potential therapeutic utility since it can be used for specifically

targeting tumor vasculature or for promoting angiogenic processes in certain organs such as an

ischemic heart

Post-translational modifications:

Glycosylated¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_001137.2

ENSEMBL proteins:

ENSP00000297450 ENSP00000379165

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Millipore Purified and/or Recombinant ANGPT1 Protein
	Sigma-Aldrich Proteins for ANGPT1
	R&D Systems Recombinant & Natural Proteins for ANGPT1 (Angiopoietin-1)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Angiopoietin 1)
	Human Recombinant Proteins from Abnova (ANGPT1)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--

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Antibodies for ANGPT1:

	Invitrogen Antibodies for ANGPT1
	Millipore Mono- and Polyclonal Antibodies for the study of ANGPT1
	Sigma-Aldrich Antibodies for ANGPT1
	R&D Systems Antibodies for ANGPT1 (Angiopoietin-1)
	Antibodies from Abcam (Angiopoietin 1), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Novus Biologicals Antibody for ANGPT1

Assays for ANGPT1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	R&D Systems ELISAs for ANGPT1 (Angiopoietin-1) (see all)
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q15389

ProtoNet protein and cluster: Q15389

1 Blocks protein family: IPB002181 Fibrinogen

UniProtKB/Swiss-Prot: ANGP1_HUMAN, Q15389

Similarity: Contains 1 fibrinogen C-terminal domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ANGPT1)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001146

Applied Biosystems Silencer® siRNAs for ANGPT1

Sigma-Aldrich siRNA and siRNA Panels for ANGPT1

Sigma-Aldrich shRNA Panels and shRNA for ANGPT1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for ANGPT1
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_001146
Myc/DDK tagged cDNA clone in CMV expression vector: NM_001146
untagged cDNA clone in CMV expression vector: NM_001146

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001146

UniProtKB/Swiss-Prot: ANGP1_HUMAN, Q15389

Function: Binds and activates TIE2 receptor by inducing its tyrosine phosphorylation. Implicated in

endothelial developmental processes later and distinct from that of VEGF. Appears to play a

crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix

and mesenchyme. Mediates blood vessel maturation/stability. It may play an important role in the

heart early development

Genatlas biochemistry entry for ANGPT1:

angiopoietin 1,75kDa,secreted ligand for the vascular endothelial restricted receptor tyrosine

kinase TEK,including phosphorylation of TEK,widely expressed,involved in late stages of

angiogenesis,promoting angiogenic remodeling as well as vessel maturation and stabilization

4 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Angpt1):

embryogenesis

lethality-prenatal/perinatal

muscle

1 Gene Ontology (GO) molecular function term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005102	receptor binding	TAS	8980223 10766762

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

3 Sigma-Aldrich "Your Favorite Gene" Pathways for ANGPT1 (Your Favorite Gene powered by Ingenuity)

Ephrin Receptor Signaling
Angiopoietin Signaling
IL-8 Signaling

GeneDecks ANGPT1 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for ANGPT1

5/57 Interacting proteins for ANGPT1 (ENSP00000297450³) via UniProtKB, MINT, and/or STRING (see all 57 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ELF2	ENSP00000368868³	STRING (score=.986)
ITGA5	ENSP00000293379³	STRING (score=.969)
TIE1	ENSP00000361554³	STRING (score=.965)
TNIP2	ENSP00000321203³	STRING (score=.951)
MMP2	ENSP00000219070³	STRING (score=.94)

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4 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001525	angiogenesis	IEA	--
GO:0007165	signal transduction	TAS	10766762
GO:0007275	multicellular organismal development	IEA	--
GO:0030154	cell differentiation	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for ANGPT1
10/23 Novoseek chemical compound relationships for ANGPT1 gene (see all 23 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
tyrosine	63.04	98	18848573 (3), 17595127 (3), 10706866 (2), 8980223 (2) (see all 58)
ameroid	54.87	1	16547766 (1)
matrigel	46.58	3	16754788 (1), 15501241 (1), 12759249 (1)
wortmannin	43.00	2	16447257 (1), 16826573 (1)
phosphatidylinositol	36.54	20	17599743 (3), 11729102 (3), 16000309 (3), 16372478 (2) (see all 9)
tween	32.05	4	16363251 (1), 16164572 (1)
ribonucleic acid	17.86	4	11397875 (1), 11095472 (1), 11297624 (1)
nitric oxide	5.73	18	12759249 (2), 16943586 (2), 15466636 (1), 17526946 (1) (see all 10)
guanylate	4.30	3	17526946 (1), 18567719 (1), 16943586 (1)
glucose	2.52	1	18436850 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ANGPT1)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001146

Sigma-Aldrich siRNA and siRNA Panels for ANGPT1

Sigma-Aldrich shRNA Panels and shRNA for ANGPT1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001146

REFSEQ mRNAs for ANGPT1 gene:

NM_001146.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001146

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001146
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001146
                                 untagged cDNA clone in CMV expression vector: NM_001146

Additional cDNA sequence:

AB084454.1 AK300319.1 AK304717.1 AY121504.1 AY124380.1 BC029406.1 BC152411.1 BC152419.1

BX648814.1 D13628.2 U83508.1

6 DOTS entries:

DT.409144 DT.92048735 DT.91826443 DT.95268809 DT.95268811 DT.95268810

24/75 AceView cDNA sequences (see all 75 ):

AW296269 U83508 D13628 CB959296 NM_139290 AI753541 BF195841 CA442002

AB084454 AL700970 AY124380 AA903299 BU625006 AW044503 AI658562 CA394153

NM_001146 BU627306 AY121504 CA391291 BF435199 BF224438 BG770949 BG569826

highest scoring ESTs for ANGPT1:

U83508 AB084454 AL598318 AL700401 AL700429 AL700970 AY121504 AY124380 BM146223 BX504259

Unigene Cluster for ANGPT1:

Angiopoietin 1

Hs.369675 [show with all ESTs]

Unigene Representative Sequence: BX648814

GeneLoc Exon Structure

5/9 Alternative Splicing Database (ASD) splice patterns (SP) for ANGPT1 (see all 9 )

ExUns:	1a	·	1b	·	1c	^	2	^	3	^	4a	·	4b	^	5	^	6	^	7a	·	7b	^	8a	·	8b	^	9a	·	9b	·	9c	^	10a	·	10b	·	10c	·	10d	^	11	^	12a	·	12b	·	12c	·	12d
SP1:							-		-						-												-										-		-
SP2:							-		-						-												-										-		-
SP3:																											-				-		-				-		-
SP4:																											-
SP5:																							-		-		-						-		-		-		-

About this scheme

ECgene alternative splicing isoforms for ANGPT1

2 Ensembl transcripts including schematic representations:

ENST00000297450 ENST00000395820

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

ANGPT1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ANGPT1

¹ / ² / ³

7 probe-sets matching ANGPT1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
1929_at²^{, 3}	U95-A	1	1.00	1.00	0.99	0.71	U83508	1.00	0.90	0.95	1
39315_at²^{, 3}	U95-A	1	1.00	1.00	0.99	1.29	U83508	1.00	0.90	0.95	1
205609_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_001146	0.60	1.00	0.82	1
205608_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	U83508	1.00	0.90	0.95	1
205609_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
1552939_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
205608_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks ANGPT1 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TGGTTTCTAT

SOURCE GeneReport for Unigene cluster: Hs.369675
Expression variation in blood from EXPOLDB for ANGPT1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ANGPT1 gene from 5/8 species (see all 8 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	ANGPT1¹	--	angiopoietin 1	95.57(n) 97.79(a)	403656 NM_001005754.2 NP_001005754.1
chimpanzee (Pan troglodytes)	ANGPT1¹	--	angiopoietin 1	98.52(n) 98.52(a)	464334 XM_519904.2 XP_519904.2
cow (Bos taurus)	ANGPT1¹	--	angiopoietin 1	94.37(n) 98.39(a)	282140 NM_001076797.1 NP_001070265.1
rat (Rattus norvegicus)	Angpt1¹	--	angiopoietin 1	90.88(n) 97.18(a)	89807 NM_053546.1 NP_445998.1
mouse (Mus musculus)	Angpt1^{1, 5}	15 (14.30 cM)⁵	angiopoietin 1^{1, 5}	91.83(n)¹ 97.39(a)¹	11600¹ NM_009640.3¹ NP_033770.2¹ AK004193⁵ AK012027⁵ (see all 10)

About this table Species with no ortholog for ANGPT1

ENSEMBL Gene Tree for ANGPT1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for ANGPT1 gene

ANGPT4² ANGPT2²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/1546 NCBI SNPs in ANGPT1 are shown (see all 1546 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 535)

AB	SNP ID	Valid	Chr 8 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs1954727^1,2	A,C,F,H,O	108332310(-)	`TAAAAC/GCAAGT`	1	--	ut3¹		9	EU EA WA MN NA	1158
	rs2507799^1,2	C,F,H	108330984(+)	`AAATTC/GGAATA`	1	--	ut3¹		5	EU EA WA NA	456
	rs2507800^1,2	A,C,F	108331845(+)	`TATATT/ATCCCT`	1	--	ut3¹		5	MN EA NA	586
--	rs41322349^1,2	C,F	108332037(-)	`CTAATT/CAATCT`	1	--	ut3¹		5	EU EA WA NA	466
	rs34145387^1,2	C,F	108579732(+)	`AATGAT/AAAACC`	1	--	ng3¹		1	NA	48
	rs4430064^1,2	H	108580957(+)	`ATTTTA/CTCAAT`	1	--	ng3¹		4	EU EA WA	418
--	rs45517437^1,2	F	108330984(-)	`ATGTGG/CAATTT`	1	--	ut3¹		1	NA	46
--	rs41516446^1,2	F	108331018(-)	`ATTCT-/TTTCA TTTAA`	1	--	ut3¹		1	NA	48
--	rs45614542^1,2	F	108331016(-)	`TATTA-/CATTT AATTG`	1	--	ut3¹		1	NA	46
--	rs45532734^1,2	F	108331890(-)	`AAAATA/TATATA`	1	--	ut3¹		1	NA	48

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HapMap Linkage Disequilibrium images for ANGPT1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 601667

10/83 Novoseek disease relationships for ANGPT1 gene (see all 83 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
neovascularization	76.68	30	9710115 (4), 17376288 (2), 9808608 (1), 11677194 (1) (see all 19)
tumors	46.55	187	19018775 (7), 12810673 (6), 11245414 (5), 16552969 (5) (see all 75)
metastasis	32.20	9	16465407 (2), 14607656 (1), 18375246 (1), 17972146 (1) (see all 6)
inflammation	30.01	32	16741035 (3), 17322110 (3), 14715662 (2), 17560831 (2) (see all 20)
proliferative diabetic retinopathy	28.47	1	15774928 (1)
hypertension pulmonary	26.32	21	11436038 (4), 15678035 (3), 14759414 (3), 12571257 (2) (see all 8)
preeclampsia	25.95	6	16363251 (1), 17409768 (1), 12548213 (1), 16182107 (1)
astrocytoma	23.33	11	16354591 (3), 11304469 (2), 15453096 (2), 10506510 (1) (see all 5)
acute respiratory distress	23.03	1	17322110 (1)
granuloma pyogenic	20.14	2	10929871 (2)

About this table

Human Genome Epidemiology Navigator: ANGPT1 (3 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/483 PubMed articles for ANGPT1 gene (see all 483 ):

Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning. (PubMed id 8980223)^{1, 3, 4} Davis S....Yancopoulos G.D. (1996)
Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)^{3, 4} Nakajima D.... Nagase T. (2002)
Endothelial Tie2/Tek ligands angiopoietin-1 (ANGPT1) and angiopoietin-2 (ANGPT2): regional localization of the human genes to 8q22.3-q23 and 8p23. (PubMed id 9545648)^{2, 3} Cheung A.H....Marsden P.A. (1998)
Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1. (PubMed id 7584026)^{3, 4} Nomura N....Tabata S. (1994)
Angiopoietin-1 inhibits vascular permeability, angiogenesis, and growth of hepatic colon cancer tumors. (PubMed id 12810673)^{1, 3} Stoeltzing O....Ellis L.M. (2003)
Oligomerization and multimerization are critical for angiopoietin-1 to bind and phosphorylate Tie2. (PubMed id 15769741)^{1, 3} Kim K.T....Koh G.Y. (2005)
ESE-1 is a novel transcriptional mediator of angiopoietin-1 expression in the setting of inflammation. (PubMed id 14715662)^{1, 3} Brown C.... Oettgen P. (2004)
Identification of a family of alternatively spliced mRNA species of angiopoietin-1. (PubMed id 10706866)^{1, 3} Huang Y.Q....Karpatkin S. (2000)
Parathyroid hormone (1-34) augments angiopoietin-1 expression in human osteoblast-like cells. (PubMed id 17039426)^{1, 3} Park J.H....Baek H.S. (2006)
Overexpression of angiopoietin-1 and angiopoietin-2 in hepatocellular carcinoma. (PubMed id 15094228)^{1, 3} Torimura T....Kojiro M. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 284	HGNC: 484	AceView: ANGPT1	Ensembl:ENSG00000154188	euGenes: HUgn284
ECgene: ANGPT1	H-InvDB: ANGPT1

(According to HUGE)
About This Section

HUGE: KIAA0003

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for ANGPT1	Genetics and Cytogenetics in Oncology and Haematology
Wikipedia	http://en.wikipedia.org/wiki/Angiopoietin

Licensable Technologies for ANGPT1
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for ANGPT1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ANGPT1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for ANGPT1		Antibodies for ANGPT1
	Explore super-pooled esiRNAs		Proteins for ANGPT1
	Lentivirus-delivered shRNAs for ANGPT1		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
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Antibodies for ANGPT1

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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ANGPT1 Gene at Home site.
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ANGPT1 Gene

protein-coding GIFtS: 66

Aliases &
Descriptions
for ANGPT1

Summaries
for ANGPT1

Genomic Location
for ANGPT1

Proteins
for ANGPT1

Protein Domains/
Families
for ANGPT1

Gene Function
for ANGPT1

Pathways & Interactions
for ANGPT1

Drugs & Compounds
for ANGPT1

Transcripts
for ANGPT1

Expression
for ANGPT1

Orthologs
for ANGPT1

Paralogs
for ANGPT1

SNPs/Variants
for ANGPT1

Disorders & Mutations
for ANGPT1

Medical News
for ANGPT1

Publications
for ANGPT1

Search for ANGPT1

Genome Databases showing ANGPT1

Other Databases showing ANGPT1

Specialized Databases showing ANGPT1

Licensable Technologies
for ANGPT1

Services
for ANGPT1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ANGPT1 Gene

protein-coding GIFtS: 66

Aliases & Descriptionsfor ANGPT1

Summariesfor ANGPT1

Genomic Locationfor ANGPT1

Proteinsfor ANGPT1

Protein Domains/Familiesfor ANGPT1

Gene Functionfor ANGPT1

Pathways & Interactionsfor ANGPT1

Drugs & Compoundsfor ANGPT1

Transcriptsfor ANGPT1

Expression for ANGPT1

Orthologsfor ANGPT1

Paralogsfor ANGPT1

SNPs/Variantsfor ANGPT1

Disorders & Mutationsfor ANGPT1

Medical Newsfor ANGPT1

Publicationsfor ANGPT1

Search for ANGPT1

Genome Databases showing ANGPT1

Other Databases showing ANGPT1

Specialized Databases showing ANGPT1

Licensable Technologiesfor ANGPT1

Servicesfor ANGPT1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ANGPT1

Summaries
for ANGPT1

Genomic Location
for ANGPT1

Proteins
for ANGPT1

Protein Domains/
Families
for ANGPT1

Gene Function
for ANGPT1

Pathways & Interactions
for ANGPT1

Drugs & Compounds
for ANGPT1

Transcripts
for ANGPT1

Expression
for ANGPT1

Orthologs
for ANGPT1

Paralogs
for ANGPT1

SNPs/Variants
for ANGPT1

Disorders & Mutations
for ANGPT1

Medical News
for ANGPT1

Publications
for ANGPT1

Licensable Technologies
for ANGPT1

Services
for ANGPT1