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Aliases for ANGEL2 Gene

Aliases for ANGEL2 Gene

  • Angel Homolog 2 (Drosophila) 2 3 5
  • KIAA0759L 3 4
  • Ccr4d 3

External Ids for ANGEL2 Gene

Previous GeneCards Identifiers for ANGEL2 Gene

  • GC01M209555
  • GC01M211232
  • GC01M213165
  • GC01M183840

Summaries for ANGEL2 Gene

GeneCards Summary for ANGEL2 Gene

ANGEL2 (Angel Homolog 2 (Drosophila)) is a Protein Coding gene. An important paralog of this gene is PDE12.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANGEL2 Gene

Genomics for ANGEL2 Gene

Regulatory Elements for ANGEL2 Gene

Promoters for ANGEL2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ANGEL2 on UCSC Golden Path with GeneCards custom track

Genomic Location for ANGEL2 Gene

212,992,182 bp from pter
213,015,875 bp from pter
23,694 bases
Minus strand

Genomic View for ANGEL2 Gene

Genes around ANGEL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANGEL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANGEL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANGEL2 Gene

Proteins for ANGEL2 Gene

  • Protein details for ANGEL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein angel homolog 2
    Protein Accession:
    Secondary Accessions:
    • B7Z2U4
    • D3DTA3
    • Q86X13
    • Q8NHH3

    Protein attributes for ANGEL2 Gene

    544 amino acids
    Molecular mass:
    62339 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH47469.1; Type=Erroneous termination; Positions=456; Note=Translated as Ser.; Evidence={ECO:0000305};

    Alternative splice isoforms for ANGEL2 Gene


neXtProt entry for ANGEL2 Gene

Proteomics data for ANGEL2 Gene at MOPED

Post-translational modifications for ANGEL2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ANGEL2 Gene

Antibody Products

No data available for DME Specific Peptides for ANGEL2 Gene

Domains & Families for ANGEL2 Gene

Protein Domains for ANGEL2 Gene


Suggested Antigen Peptide Sequences for ANGEL2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the CCR4/nocturin family.
  • Belongs to the CCR4/nocturin family.
genes like me logo Genes that share domains with ANGEL2: view

No data available for Gene Families for ANGEL2 Gene

Function for ANGEL2 Gene

Animal Model Products

  • Taconic Biosciences Mouse Models for ANGEL2

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ANGEL2 Gene

Localization for ANGEL2 Gene

Subcellular locations from

Jensen Localization Image for ANGEL2 Gene COMPARTMENTS Subcellular localization image for ANGEL2 gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for ANGEL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 17178830
genes like me logo Genes that share ontologies with ANGEL2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ANGEL2 Gene

Pathways & Interactions for ANGEL2 Gene

SuperPathways for ANGEL2 Gene

No Data Available

Interacting Proteins for ANGEL2 Gene

Gene Ontology (GO) - Biological Process for ANGEL2 Gene


No data available for Pathways by source and SIGNOR curated interactions for ANGEL2 Gene

Drugs & Compounds for ANGEL2 Gene

No Compound Related Data Available

Transcripts for ANGEL2 Gene

Unigene Clusters for ANGEL2 Gene

Angel homolog 2 (Drosophila):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ANGEL2 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b
SP1: - - - - -
SP2: -
SP3: - - - - - - -
SP4: - -
SP7: - - -

Relevant External Links for ANGEL2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ANGEL2 Gene

mRNA expression in normal human tissues for ANGEL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ANGEL2 Gene

This gene is overexpressed in CD8 Tcells (17.6), Fetal heart (12.4), Peripheral blood mononuclear cells (12.4), and CD4 Tcells (9.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ANGEL2 Gene

SOURCE GeneReport for Unigene cluster for ANGEL2 Gene Hs.157078

genes like me logo Genes that share expression patterns with ANGEL2: view

Protein tissue co-expression partners for ANGEL2 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ANGEL2 Gene

Orthologs for ANGEL2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ANGEL2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ANGEL2 35
  • 92.46 (n)
  • 91.73 (a)
  • 92 (a)
(Canis familiaris)
Mammalia ANGEL2 35
  • 93.5 (n)
  • 93.75 (a)
  • 94 (a)
(Mus musculus)
Mammalia Angel2 35
  • 84.5 (n)
  • 85.48 (a)
Angel2 16
Angel2 36
  • 85 (a)
(Pan troglodytes)
Mammalia ANGEL2 35
  • 99.88 (n)
  • 100 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Angel2 35
  • 84.93 (n)
  • 87.36 (a)
(Monodelphis domestica)
Mammalia ANGEL2 36
  • 77 (a)
(Ornithorhynchus anatinus)
Mammalia ANGEL2 36
  • 77 (a)
(Gallus gallus)
Aves ANGEL2 35
  • 70.48 (n)
  • 69.19 (a)
  • 53 (a)
(Anolis carolinensis)
Reptilia ANGEL2 36
  • 57 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia angel2 35
  • 63.26 (n)
  • 63.05 (a)
Str.11476 35
(Danio rerio)
Actinopterygii angel2 35
  • 58.83 (n)
  • 59.22 (a)
wufl78e02 35
angel2 36
  • 44 (a)
fruit fly
(Drosophila melanogaster)
Insecta angel 36
  • 31 (a)
(Caenorhabditis elegans)
Secernentea W02G9.5 35
  • 48 (n)
  • 39 (a)
angl-1 36
  • 32 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CCR4 36
  • 13 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5917 36
  • 23 (a)
Species with no ortholog for ANGEL2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ANGEL2 Gene

Gene Tree for ANGEL2 (if available)
Gene Tree for ANGEL2 (if available)

Paralogs for ANGEL2 Gene

Paralogs for ANGEL2 Gene

(1) SIMAP similar genes for ANGEL2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ANGEL2: view

Variants for ANGEL2 Gene

Sequence variations from dbSNP and Humsavar for ANGEL2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs11542154 - 213,013,189(-) GGAGA(C/T)CTGAC intron-variant, nc-transcript-variant, upstream-variant-2KB, reference, missense
rs10366 -- 213,006,597(+) TTAGG(G/T)AGACA intron-variant
rs14007 -- 212,992,415(+) CCTTT(C/G)CATTT nc-transcript-variant, utr-variant-3-prime
rs1027422 -- 212,998,282(+) ctgtg(A/G)tctca intron-variant
rs1135238 -- 213,007,008(-) caagt(A/G)atcct intron-variant

Variation tolerance for ANGEL2 Gene

Residual Variation Intolerance Score: 39.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.36; 41.86% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ANGEL2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ANGEL2 Gene

Disorders for ANGEL2 Gene

Relevant External Links for ANGEL2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ANGEL2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANGEL2 Gene

Publications for ANGEL2 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 67
  2. Genomic structure and evolutionary context of the human feline leukemia virus subgroup C receptor (hFLVCR) gene: evidence for block duplications and de novo gene formation within duplicons of the hFLVCR locus. (PMID: 11943475) Lipovich L. … Quigley J.G. (Gene 2002) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. TRIM65 regulates microRNA activity by ubiquitination of TNRC6. (PMID: 24778252) Li S. … Dorf M.E. (Proc. Natl. Acad. Sci. U.S.A. 2014) 3
  5. hnRNPA1 couples nuclear export and translation of specific mRNAs downstream of FGF-2/S6K2 signalling. (PMID: 25324306) Roy R. … Pardo O.E. (Nucleic Acids Res. 2014) 3

Products for ANGEL2 Gene

Sources for ANGEL2 Gene

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