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Aliases for ANGEL2 Gene

Aliases for ANGEL2 Gene

  • Angel Homolog 2 2 3 5
  • KIAA0759L 3 4
  • Angel Homolog 2 (Drosophila) 2
  • Protein Angel Homolog 2 3
  • Ccr4d 3

External Ids for ANGEL2 Gene

Previous GeneCards Identifiers for ANGEL2 Gene

  • GC01M209555
  • GC01M211232
  • GC01M213165
  • GC01M183840

Summaries for ANGEL2 Gene

GeneCards Summary for ANGEL2 Gene

ANGEL2 (Angel Homolog 2) is a Protein Coding gene. An important paralog of this gene is ANGEL1.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANGEL2 Gene

Genomics for ANGEL2 Gene

Regulatory Elements for ANGEL2 Gene

Enhancers for ANGEL2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G212481 2 FANTOM5 Ensembl ENCODE dbSUPER 23.1 +530.0 529959 8.2 PKNOX1 FOXA2 ARNT SIN3A FEZF1 ZNF2 ZNF766 FOS DEK SP3 LOC105372907 ATF3 ANGEL2 BATF3 LOC105372908
GH01G212789 1.2 ENCODE 31.3 +224.3 224279 4.4 MLX CREB3L1 AGO1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 FLVCR1-AS1 ANGEL2 FLVCR1 TATDN3 RPS28P2 ENSG00000235182 VASH2 BATF3 NSL1 PIR52879
GH01G212283 1.7 FANTOM5 ENCODE dbSUPER 13.2 +729.9 729939 4.4 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC TBX21 MEF2D LOC101929541 TMEM206 PPP2R5A ANGEL2 INTS7 ENSG00000230063
GH01G212557 1.6 Ensembl ENCODE dbSUPER 13.3 +455.9 455925 4.8 HDGF PKNOX1 CREB3L1 ARNT ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF766 ANGEL2 ENSG00000260805 ATF3
GH01G212977 1.7 FANTOM5 Ensembl ENCODE dbSUPER 12.1 +35.7 35727 5.6 HDAC1 TBP FOXA2 CBX3 TBL1XR1 WRNIP1 BMI1 EGR1 ZNF207 RELB RPS6KC1 VASH2 BATF3 ANGEL2 TATDN3
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ANGEL2 on UCSC Golden Path with GeneCards custom track

Promoters for ANGEL2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000019797 375 1801 HDGF PKNOX1 ARNT SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF766 CBX5

Genomic Location for ANGEL2 Gene

Chromosome:
1
Start:
212,992,182 bp from pter
End:
213,015,875 bp from pter
Size:
23,694 bases
Orientation:
Minus strand

Genomic View for ANGEL2 Gene

Genes around ANGEL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANGEL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANGEL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANGEL2 Gene

Proteins for ANGEL2 Gene

  • Protein details for ANGEL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5VTE6-ANGE2_HUMAN
    Recommended name:
    Protein angel homolog 2
    Protein Accession:
    Q5VTE6
    Secondary Accessions:
    • B7Z2U4
    • D3DTA3
    • Q86X13
    • Q8NHH3

    Protein attributes for ANGEL2 Gene

    Size:
    544 amino acids
    Molecular mass:
    62339 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH47469.1; Type=Erroneous termination; Positions=456; Note=Translated as Ser.; Evidence={ECO:0000305};

    Alternative splice isoforms for ANGEL2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ANGEL2 Gene

Post-translational modifications for ANGEL2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ANGEL2 Gene

Domains & Families for ANGEL2 Gene

Protein Domains for ANGEL2 Gene

Suggested Antigen Peptide Sequences for ANGEL2 Gene

Graphical View of Domain Structure for InterPro Entry

Q5VTE6

UniProtKB/Swiss-Prot:

ANGE2_HUMAN :
  • Belongs to the CCR4/nocturin family.
Family:
  • Belongs to the CCR4/nocturin family.
genes like me logo Genes that share domains with ANGEL2: view

No data available for Gene Families for ANGEL2 Gene

Function for ANGEL2 Gene

Gene Ontology (GO) - Molecular Function for ANGEL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003730 mRNA 3-UTR binding IDA 22547059
genes like me logo Genes that share ontologies with ANGEL2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for ANGEL2

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ANGEL2 Gene

Localization for ANGEL2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ANGEL2 gene
Compartment Confidence
nucleus 5
mitochondrion 2
cytosol 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for ANGEL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 17178830
GO:0015030 Cajal body IDA 17178830
genes like me logo Genes that share ontologies with ANGEL2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ANGEL2 Gene

Pathways & Interactions for ANGEL2 Gene

SuperPathways for ANGEL2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ANGEL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045930 negative regulation of mitotic cell cycle IMP 22547059
GO:0070935 3-UTR-mediated mRNA stabilization IMP 22547059
genes like me logo Genes that share ontologies with ANGEL2: view

No data available for Pathways by source and SIGNOR curated interactions for ANGEL2 Gene

Drugs & Compounds for ANGEL2 Gene

No Compound Related Data Available

Transcripts for ANGEL2 Gene

Unigene Clusters for ANGEL2 Gene

Angel homolog 2 (Drosophila):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ANGEL2 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b
SP1: - - - - -
SP2: -
SP3: - - - - - - -
SP4: - -
SP5:
SP6:
SP7: - - -
SP8:

Relevant External Links for ANGEL2 Gene

GeneLoc Exon Structure for
ANGEL2
ECgene alternative splicing isoforms for
ANGEL2

Expression for ANGEL2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ANGEL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ANGEL2 Gene

This gene is overexpressed in CD8 Tcells (17.6), Fetal heart (12.4), Peripheral blood mononuclear cells (12.4), and CD4 Tcells (9.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ANGEL2 Gene



Protein tissue co-expression partners for ANGEL2 Gene

NURSA nuclear receptor signaling pathways regulating expression of ANGEL2 Gene:

ANGEL2

SOURCE GeneReport for Unigene cluster for ANGEL2 Gene:

Hs.157078

Evidence on tissue expression from TISSUES for ANGEL2 Gene

  • Nervous system(4.6)
genes like me logo Genes that share expression patterns with ANGEL2: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ANGEL2 Gene

Orthologs for ANGEL2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ANGEL2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ANGEL2 35 34
  • 99.88 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ANGEL2 35 34
  • 93.5 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ANGEL2 34 35
  • 92.46 (n)
rat
(Rattus norvegicus)
Mammalia Angel2 34
  • 84.93 (n)
mouse
(Mus musculus)
Mammalia Angel2 34 16 35
  • 84.5 (n)
oppossum
(Monodelphis domestica)
Mammalia ANGEL2 35
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ANGEL2 35
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves ANGEL2 35 34
  • 70.48 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ANGEL2 35
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia angel2 34
  • 63.26 (n)
Str.11476 34
zebrafish
(Danio rerio)
Actinopterygii angel2 35 34
  • 58.83 (n)
OneToOne
wufl78e02 34
fruit fly
(Drosophila melanogaster)
Insecta angel 35
  • 31 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea W02G9.5 34
  • 48 (n)
angl-1 35
  • 32 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CCR4 35
  • 13 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5917 35
  • 23 (a)
OneToMany
Species where no ortholog for ANGEL2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ANGEL2 Gene

ENSEMBL:
Gene Tree for ANGEL2 (if available)
TreeFam:
Gene Tree for ANGEL2 (if available)

Paralogs for ANGEL2 Gene

Paralogs for ANGEL2 Gene

(1) SIMAP similar genes for ANGEL2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ANGEL2: view

Variants for ANGEL2 Gene

Sequence variations from dbSNP and Humsavar for ANGEL2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000050349 -- 213,006,966(+) GCACA(C/T)ATCTC intron-variant
rs1000051498 -- 213,003,780(+) GATAG(A/G)GCTGC intron-variant
rs1000106157 -- 212,994,079(+) GAGTT(C/T)GAGAC nc-transcript-variant, utr-variant-3-prime
rs1000168899 -- 212,998,998(+) CCTCA(A/G)CCTAC intron-variant
rs1000313010 -- 213,004,088(+) TAGTC(C/T)CAGCT intron-variant

Variation tolerance for ANGEL2 Gene

Residual Variation Intolerance Score: 39.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.36; 41.86% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ANGEL2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ANGEL2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ANGEL2 Gene

Disorders for ANGEL2 Gene

Relevant External Links for ANGEL2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ANGEL2

No disorders were found for ANGEL2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANGEL2 Gene

Publications for ANGEL2 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. Genomic structure and evolutionary context of the human feline leukemia virus subgroup C receptor (hFLVCR) gene: evidence for block duplications and de novo gene formation within duplicons of the hFLVCR locus. (PMID: 11943475) Lipovich L. … Quigley J.G. (Gene 2002) 2 3 64
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64
  5. The variant Polycomb Repressor Complex 1 component PCGF1 interacts with a pluripotency sub-network that includes DPPA4, a regulator of embryogenesis. (PMID: 26687479) Oliviero G. … Cagney G. (Sci. Rep. 2015) 3 64

Products for ANGEL2 Gene

Sources for ANGEL2 Gene

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