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Aliases for ANGEL1 Gene

Aliases for ANGEL1 Gene

  • Angel Homolog 1 (Drosophila) 2 3 5
  • KIAA0759 3 4
  • Ccr4e 3

External Ids for ANGEL1 Gene

Previous HGNC Symbols for ANGEL1 Gene

  • KIAA0759

Previous GeneCards Identifiers for ANGEL1 Gene

  • GC14M076324
  • GC14M077255
  • GC14M057422

Summaries for ANGEL1 Gene

GeneCards Summary for ANGEL1 Gene

ANGEL1 (Angel Homolog 1 (Drosophila)) is a Protein Coding gene. An important paralog of this gene is PDE12.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANGEL1 Gene

Genomics for ANGEL1 Gene

Regulatory Elements for ANGEL1 Gene

Genomic Location for ANGEL1 Gene

76,786,178 bp from pter
76,828,473 bp from pter
42,296 bases
Minus strand

Genomic View for ANGEL1 Gene

Genes around ANGEL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANGEL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANGEL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANGEL1 Gene

Proteins for ANGEL1 Gene

  • Protein details for ANGEL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein angel homolog 1
    Protein Accession:
    Secondary Accessions:
    • B4DWL7
    • O94859
    • Q8NCS9

    Protein attributes for ANGEL1 Gene

    670 amino acids
    Molecular mass:
    75276 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA34479.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAG63079.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ANGEL1 Gene

Proteomics data for ANGEL1 Gene at MOPED

Post-translational modifications for ANGEL1 Gene

  • Ubiquitination at Lys 29, Lys 416, Lys 460, and Lys 475
  • Modification sites at PhosphoSitePlus

Other Protein References for ANGEL1 Gene

No data available for DME Specific Peptides for ANGEL1 Gene

Domains & Families for ANGEL1 Gene

Protein Domains for ANGEL1 Gene


Suggested Antigen Peptide Sequences for ANGEL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the CCR4/nocturin family.
  • Belongs to the CCR4/nocturin family.
genes like me logo Genes that share domains with ANGEL1: view

No data available for Gene Families for ANGEL1 Gene

Function for ANGEL1 Gene

genes like me logo Genes that share phenotypes with ANGEL1: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ANGEL1 Gene

Localization for ANGEL1 Gene

Subcellular locations from

Jensen Localization Image for ANGEL1 Gene COMPARTMENTS Subcellular localization image for ANGEL1 gene
Compartment Confidence
cytosol 5
nucleus 5
endoplasmic reticulum 4
extracellular 2
golgi apparatus 1
lysosome 1
mitochondrion 1
peroxisome 1
plasma membrane 1
vacuole 1

Gene Ontology (GO) - Cellular Components for ANGEL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IDA 23814182
GO:0005801 cis-Golgi network IDA 23814182
GO:0005829 cytosol IDA 23814182
genes like me logo Genes that share ontologies with ANGEL1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ANGEL1 Gene

Pathways & Interactions for ANGEL1 Gene

SuperPathways for ANGEL1 Gene

No Data Available

Interacting Proteins for ANGEL1 Gene

Gene Ontology (GO) - Biological Process for ANGEL1 Gene


No data available for Pathways by source and SIGNOR curated interactions for ANGEL1 Gene

Drugs & Compounds for ANGEL1 Gene

No Compound Related Data Available

Transcripts for ANGEL1 Gene

Unigene Clusters for ANGEL1 Gene

Angel homolog 1 (Drosophila):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ANGEL1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13a · 13b
SP1: - - - -
SP3: - - - - - - -

Relevant External Links for ANGEL1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ANGEL1 Gene

mRNA expression in normal human tissues for ANGEL1 Gene

Protein differential expression in normal tissues from HIPED for ANGEL1 Gene

This gene is overexpressed in Lung (40.7) and Testis (19.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ANGEL1 Gene

SOURCE GeneReport for Unigene cluster for ANGEL1 Gene Hs.497448

genes like me logo Genes that share expression patterns with ANGEL1: view

Protein tissue co-expression partners for ANGEL1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ANGEL1 Gene

Orthologs for ANGEL1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ANGEL1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ANGEL1 35
  • 89.81 (n)
  • 91.45 (a)
  • 91 (a)
(Canis familiaris)
Mammalia ANGEL1 35
  • 91.02 (n)
  • 93.03 (a)
  • 91 (a)
(Mus musculus)
Mammalia Angel1 35
  • 89.46 (n)
  • 91 (a)
Angel1 16
Angel1 36
  • 91 (a)
(Pan troglodytes)
Mammalia ANGEL1 35
  • 99.45 (n)
  • 99.4 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Angel1 35
  • 89.46 (n)
  • 90.85 (a)
(Monodelphis domestica)
Mammalia ANGEL1 36
  • 77 (a)
(Ornithorhynchus anatinus)
Mammalia ANGEL1 36
  • 67 (a)
(Gallus gallus)
Aves ANGEL1 35
  • 66.1 (n)
  • 63.35 (a)
  • 58 (a)
(Anolis carolinensis)
Reptilia ANGEL1 36
  • 59 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia angel1 35
  • 56.74 (n)
  • 54.53 (a)
(Danio rerio)
Actinopterygii angel1 36
  • 37 (a)
ANGEL1 (2 of 2) 36
  • 49 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011401 35
  • 48.39 (n)
  • 39.76 (a)
fruit fly
(Drosophila melanogaster)
Insecta angel 35
  • 50.42 (n)
  • 39.5 (a)
angel 36
  • 35 (a)
(Caenorhabditis elegans)
Secernentea angl-1 36
  • 33 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CCR4 36
  • 15 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5917 36
  • 21 (a)
Species with no ortholog for ANGEL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ANGEL1 Gene

Gene Tree for ANGEL1 (if available)
Gene Tree for ANGEL1 (if available)

Paralogs for ANGEL1 Gene

Paralogs for ANGEL1 Gene

(1) SIMAP similar genes for ANGEL1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ANGEL1: view

Variants for ANGEL1 Gene

Sequence variations from dbSNP and Humsavar for ANGEL1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs34270005 - 76,809,287(+) CACCC(A/C/G/T)CTCCA nc-transcript-variant, reference, missense
rs2075773 - 76,803,445(+) AGCGG(A/C)AACGT nc-transcript-variant, reference, missense
rs45499197 - 76,806,649(+) GGCCA(C/G)CGAGA nc-transcript-variant, reference, missense
rs768297 -- 76,807,675(+) GTGCA(C/T)TGGAT intron-variant
rs741858 -- 76,817,736(+) cttct(C/G)ttcct intron-variant

Variation tolerance for ANGEL1 Gene

Residual Variation Intolerance Score: 60.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.32; 88.31% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ANGEL1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ANGEL1 Gene

Disorders for ANGEL1 Gene

Relevant External Links for ANGEL1

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ANGEL1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANGEL1 Gene

Publications for ANGEL1 Gene

  1. The DNA sequence and analysis of human chromosome 14. (PMID: 12508121) Heilig R. … Weissenbach J. (Nature 2003) 3 4 67
  2. Genomic structure and evolutionary context of the human feline leukemia virus subgroup C receptor (hFLVCR) gene: evidence for block duplications and de novo gene formation within duplicons of the hFLVCR locus. (PMID: 11943475) Lipovich L. … Quigley J.G. (Gene 2002) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Tracking a refined eIF4E-binding motif reveals Angel1 as a new partner of eIF4E. (PMID: 23814182) Gosselin P. … Cosson B. (Nucleic Acids Res. 2013) 3
  5. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3

Products for ANGEL1 Gene

Sources for ANGEL1 Gene

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