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Aliases for ANGEL1 Gene

Aliases for ANGEL1 Gene

  • Angel Homolog 1 (Drosophila) 2 3
  • KIAA0759 3 4
  • Protein Angel Homolog 1 3
  • Ccr4e 3

External Ids for ANGEL1 Gene

Previous HGNC Symbols for ANGEL1 Gene

  • KIAA0759

Previous GeneCards Identifiers for ANGEL1 Gene

  • GC14M076324
  • GC14M077255
  • GC14M057422

Summaries for ANGEL1 Gene

GeneCards Summary for ANGEL1 Gene

ANGEL1 (Angel Homolog 1 (Drosophila)) is a Protein Coding gene. An important paralog of this gene is PDE12.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANGEL1 Gene

Genomics for ANGEL1 Gene

Regulatory Elements for ANGEL1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ANGEL1 Gene

Start:
76,787,243 bp from pter
End:
76,826,263 bp from pter
Size:
39,021 bases
Orientation:
Minus strand

Genomic View for ANGEL1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ANGEL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANGEL1 Gene

Proteins for ANGEL1 Gene

  • Protein details for ANGEL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UNK9-ANGE1_HUMAN
    Recommended name:
    Protein angel homolog 1
    Protein Accession:
    Q9UNK9
    Secondary Accessions:
    • B4DWL7
    • O94859
    • Q8NCS9

    Protein attributes for ANGEL1 Gene

    Size:
    670 amino acids
    Molecular mass:
    75276 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA34479.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAG63079.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ANGEL1 Gene

Proteomics data for ANGEL1 Gene at MOPED

Post-translational modifications for ANGEL1 Gene

  • Ubiquitination at Lys29, Lys416, Lys460, and Lys475
  • Modification sites at PhosphoSitePlus

Other Protein References for ANGEL1 Gene

No data available for DME Specific Peptides for ANGEL1 Gene

Domains for ANGEL1 Gene

Protein Domains for ANGEL1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ANGEL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UNK9

UniProtKB/Swiss-Prot:

ANGE1_HUMAN :
  • Q9UNK9
Family:
  • Belongs to the CCR4/nocturin family.
genes like me logo Genes that share domains with ANGEL1: view

No data available for Gene Families for ANGEL1 Gene

Function for ANGEL1 Gene

Phenotypes for ANGEL1 Gene

GenomeRNAi human phenotypes for ANGEL1:
genes like me logo Genes that share phenotypes with ANGEL1: view

Animal Model Products

CRISPR Products

miRNA for ANGEL1 Gene

miRTarBase miRNAs that target ANGEL1

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ANGEL1

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targeting and HOMER Transcription for ANGEL1 Gene

Localization for ANGEL1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ANGEL1 Gene COMPARTMENTS Subcellular localization image for ANGEL1 gene
Compartment Confidence
extracellular 2
cytosol 1
lysosome 1
mitochondrion 1
nucleus 1
peroxisome 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ANGEL1 Gene

Pathways for ANGEL1 Gene

SuperPathways for ANGEL1 Gene

No Data Available

Interacting Proteins for ANGEL1 Gene

Gene Ontology (GO) - Biological Process for ANGEL1 Gene

None

No data available for Pathways by source for ANGEL1 Gene

Transcripts for ANGEL1 Gene

Unigene Clusters for ANGEL1 Gene

Angel homolog 1 (Drosophila):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ANGEL1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for ANGEL1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ANGEL1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13a · 13b
SP1: - - - -
SP2:
SP3: - - - - - - -
SP4:

Relevant External Links for ANGEL1 Gene

GeneLoc Exon Structure for
ANGEL1
ECgene alternative splicing isoforms for
ANGEL1

Expression for ANGEL1 Gene

mRNA expression in normal human tissues for ANGEL1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ANGEL1 Gene

SOURCE GeneReport for Unigene cluster for ANGEL1 Gene Hs.497448

genes like me logo Genes that share expressions with ANGEL1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ANGEL1 Gene

Orthologs for ANGEL1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ANGEL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ANGEL1 35
  • 99.45 (n)
  • 99.4 (a)
ANGEL1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ANGEL1 35
  • 89.81 (n)
  • 91.45 (a)
ANGEL1 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ANGEL1 35
  • 91.02 (n)
  • 93.03 (a)
ANGEL1 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Angel1 35
  • 89.46 (n)
  • 91 (a)
Angel1 16
Angel1 36
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ANGEL1 36
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ANGEL1 36
  • 67 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Angel1 35
  • 89.46 (n)
  • 90.85 (a)
chicken
(Gallus gallus)
Aves ANGEL1 35
  • 66.1 (n)
  • 63.35 (a)
ANGEL1 36
  • 58 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ANGEL1 36
  • 59 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia angel1 35
  • 56.74 (n)
  • 54.53 (a)
zebrafish
(Danio rerio)
Actinopterygii angel1 36
  • 37 (a)
OneToMany
ANGEL1 (2 of 2) 36
  • 49 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011401 35
  • 48.39 (n)
  • 39.76 (a)
fruit fly
(Drosophila melanogaster)
Insecta angel 35
  • 50.42 (n)
  • 39.5 (a)
angel 36
  • 35 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea angl-1 36
  • 33 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CCR4 36
  • 15 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5917 36
  • 21 (a)
OneToMany
Species with no ortholog for ANGEL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ANGEL1 Gene

ENSEMBL:
Gene Tree for ANGEL1 (if available)
TreeFam:
Gene Tree for ANGEL1 (if available)

Paralogs for ANGEL1 Gene

Paralogs for ANGEL1 Gene

Selected SIMAP similar genes for ANGEL1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ANGEL1: view

Variants for ANGEL1 Gene

Sequence variations from dbSNP and Humsavar for ANGEL1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs741858 -- 76,817,736(+) cttct(C/G)ttcct intron-variant
rs760266 -- 76,818,073(+) GGAGT(A/G/T)GCACA intron-variant
rs760267 -- 76,818,376(+) TACAG(C/T)CAATG intron-variant
rs768297 -- 76,807,675(+) GTGCA(C/T)TGGAT intron-variant
rs2037934 -- 76,815,772(+) GCTAC(C/G)GACCA intron-variant

Relevant External Links for ANGEL1 Gene

HapMap Linkage Disequilibrium report
ANGEL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ANGEL1 Gene

Disorders for ANGEL1 Gene

(1) University of Copenhagen DISEASES for ANGEL1 Gene

Relevant External Links for ANGEL1

Genetic Association Database (GAD)
ANGEL1
genes like me logo Genes that share disorders with ANGEL1: view

No data available for UniProtKB/Swiss-Prot for ANGEL1 Gene

Publications for ANGEL1 Gene

  1. The DNA sequence and analysis of human chromosome 14. (PMID: 12508121) Heilig R. … Weissenbach J. (Nature 2003) 3 4
  2. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9872452) Nagase T. … Ohara O. (DNA Res. 1998) 3 4
  3. Genomic structure and evolutionary context of the human feline leukemia virus subgroup C receptor (hFLVCR) gene: evidence for block duplications and de novo gene formation within duplicons of the hFLVCR locus. (PMID: 11943475) Lipovich L. … Quigley J.G. (Gene 2002) 2 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3

Products for ANGEL1 Gene

Sources for ANGEL1 Gene

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