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Aliases for ANGEL1 Gene

Aliases for ANGEL1 Gene

  • Angel Homolog 1 2 3 5
  • KIAA0759 3 4
  • Angel Homolog 1 (Drosophila) 2
  • Protein Angel Homolog 1 3
  • Ccr4e 3

External Ids for ANGEL1 Gene

Previous HGNC Symbols for ANGEL1 Gene

  • KIAA0759

Previous GeneCards Identifiers for ANGEL1 Gene

  • GC14M076324
  • GC14M077255
  • GC14M057422

Summaries for ANGEL1 Gene

GeneCards Summary for ANGEL1 Gene

ANGEL1 (Angel Homolog 1) is a Protein Coding gene. An important paralog of this gene is ANGEL2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANGEL1 Gene

Genomics for ANGEL1 Gene

Regulatory Elements for ANGEL1 Gene

Enhancers for ANGEL1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14F076827 0.5 Ensembl ENCODE 18 -1.0 -979 3.3 SOX13 ELF3 TFAP4 SAP130 ZFP64 ARID4B CEBPG THRB ZIC2 ZNF644 ANGEL1 ENSG00000259081 GC14P076854
GH14F076810 1 FANTOM5 ENCODE 14.5 +16.2 16229 3.4 HDGF PKNOX1 MLX ARID4B SIN3A DMAP1 ZNF143 FOS KLF13 DEK ANGEL1 ENSG00000259081 LOC100506603 LRRC74A PIR52952
GH14F076814 0.2 ENCODE 14.3 +13.0 12969 1.3 PKNOX1 ZNF781 NR2F2 VASH1 ANGEL1 ENSG00000259081 LOC100506603 PIR52952 LRRC74A
GH14F076772 0.6 Ensembl ENCODE 14.2 +55.2 55201 3.7 CTCF ESRRA PKNOX1 JUN ZNF384 RAD21 ZFHX2 GATA3 CTBP1 POLR2A ANGEL1 VASH1 ENSG00000259081 LOC100506603 ENSG00000258610
GH14F076719 1.3 Ensembl ENCODE 11 +107.8 107804 2.7 TFAP4 ESRRA ZNF384 CEBPG THRB ZNF644 RARA TEAD3 POLR2A EED VASH1 LRRC74A ANGEL1 ENSG00000259124 LOC100130048
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ANGEL1 on UCSC Golden Path with GeneCards custom track

Genomic Location for ANGEL1 Gene

76,786,178 bp from pter
76,828,473 bp from pter
42,296 bases
Minus strand

Genomic View for ANGEL1 Gene

Genes around ANGEL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANGEL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANGEL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANGEL1 Gene

Proteins for ANGEL1 Gene

  • Protein details for ANGEL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein angel homolog 1
    Protein Accession:
    Secondary Accessions:
    • B4DWL7
    • O94859
    • Q8NCS9

    Protein attributes for ANGEL1 Gene

    670 amino acids
    Molecular mass:
    75276 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA34479.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAG63079.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ANGEL1 Gene

Post-translational modifications for ANGEL1 Gene

  • Ubiquitination at Lys 29, Lys 416, Lys 460, and Lys 475
  • Modification sites at PhosphoSitePlus

Other Protein References for ANGEL1 Gene

No data available for DME Specific Peptides for ANGEL1 Gene

Domains & Families for ANGEL1 Gene

Protein Domains for ANGEL1 Gene

Suggested Antigen Peptide Sequences for ANGEL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the CCR4/nocturin family.
  • Belongs to the CCR4/nocturin family.
genes like me logo Genes that share domains with ANGEL1: view

No data available for Gene Families for ANGEL1 Gene

Function for ANGEL1 Gene

Gene Ontology (GO) - Molecular Function for ANGEL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008190 eukaryotic initiation factor 4E binding IDA 23814182
GO:0019904 protein domain specific binding IDA 23814182
genes like me logo Genes that share ontologies with ANGEL1: view
genes like me logo Genes that share phenotypes with ANGEL1: view

Animal Models for ANGEL1 Gene

MGI Knock Outs for ANGEL1:

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ANGEL1 Gene

Localization for ANGEL1 Gene

Subcellular locations from

Jensen Localization Image for ANGEL1 Gene COMPARTMENTS Subcellular localization image for ANGEL1 gene
Compartment Confidence
cytosol 5
nucleus 5
endoplasmic reticulum 4
extracellular 2
golgi apparatus 1
lysosome 1
mitochondrion 1
peroxisome 1
plasma membrane 1
vacuole 1

Gene Ontology (GO) - Cellular Components for ANGEL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 23814182
GO:0005783 endoplasmic reticulum IDA 23814182
GO:0005801 cis-Golgi network IDA 23814182
GO:0005829 cytosol IDA 23814182
GO:0048471 perinuclear region of cytoplasm IDA 23814182
genes like me logo Genes that share ontologies with ANGEL1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ANGEL1 Gene

Pathways & Interactions for ANGEL1 Gene

SuperPathways for ANGEL1 Gene

No Data Available

Interacting Proteins for ANGEL1 Gene

Gene Ontology (GO) - Biological Process for ANGEL1 Gene


No data available for Pathways by source and SIGNOR curated interactions for ANGEL1 Gene

Transcripts for ANGEL1 Gene

Unigene Clusters for ANGEL1 Gene

Angel homolog 1 (Drosophila):
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ANGEL1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13a · 13b
SP1: - - - -
SP3: - - - - - - -

Relevant External Links for ANGEL1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ANGEL1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ANGEL1 Gene

Protein differential expression in normal tissues from HIPED for ANGEL1 Gene

This gene is overexpressed in Lung (40.7) and Testis (19.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ANGEL1 Gene

Protein tissue co-expression partners for ANGEL1 Gene

NURSA nuclear receptor signaling pathways regulating expression of ANGEL1 Gene:


SOURCE GeneReport for Unigene cluster for ANGEL1 Gene:

genes like me logo Genes that share expression patterns with ANGEL1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ANGEL1 Gene

Orthologs for ANGEL1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ANGEL1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ANGEL1 34 35
  • 99.45 (n)
(Canis familiaris)
Mammalia ANGEL1 34 35
  • 91.02 (n)
(Bos Taurus)
Mammalia ANGEL1 34 35
  • 89.81 (n)
(Mus musculus)
Mammalia Angel1 34 16 35
  • 89.46 (n)
(Rattus norvegicus)
Mammalia Angel1 34
  • 89.46 (n)
(Monodelphis domestica)
Mammalia ANGEL1 35
  • 77 (a)
(Ornithorhynchus anatinus)
Mammalia ANGEL1 35
  • 67 (a)
(Gallus gallus)
Aves ANGEL1 34 35
  • 66.1 (n)
(Anolis carolinensis)
Reptilia ANGEL1 35
  • 59 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia angel1 34
  • 56.74 (n)
(Danio rerio)
Actinopterygii ANGEL1 (2 of 2) 35
  • 49 (a)
angel1 35
  • 37 (a)
fruit fly
(Drosophila melanogaster)
Insecta angel 34 35
  • 50.42 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011401 34
  • 48.39 (n)
(Caenorhabditis elegans)
Secernentea angl-1 35
  • 33 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CCR4 35
  • 15 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5917 35
  • 21 (a)
Species where no ortholog for ANGEL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ANGEL1 Gene

Gene Tree for ANGEL1 (if available)
Gene Tree for ANGEL1 (if available)

Paralogs for ANGEL1 Gene

Paralogs for ANGEL1 Gene

(1) SIMAP similar genes for ANGEL1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ANGEL1: view

Variants for ANGEL1 Gene

Sequence variations from dbSNP and Humsavar for ANGEL1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs10135075 -- 76,797,977(+) tgatt(A/G)ggtca intron-variant
rs10140528 -- 76,804,826(+) CCAAC(A/G)TGGCG intron-variant
rs10431725 -- 76,802,830(+) CCTTC(C/T)GTGTT intron-variant
rs1076584 -- 76,787,756(-) CCTCA(C/T)TCGAC intron-variant, upstream-variant-2KB, utr-variant-3-prime
rs111350779 -- 76,791,359(+) CCCGC(A/G)GGTCG reference, synonymous-codon, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ANGEL1 Gene

Variant ID Type Subtype PubMed ID
esv3551798 CNV deletion 23714750
nsv952869 CNV deletion 24416366

Variation tolerance for ANGEL1 Gene

Residual Variation Intolerance Score: 60.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.32; 88.31% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ANGEL1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANGEL1 Gene

Disorders for ANGEL1 Gene

Relevant External Links for ANGEL1

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ANGEL1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANGEL1 Gene

Publications for ANGEL1 Gene

  1. The DNA sequence and analysis of human chromosome 14. (PMID: 12508121) Heilig R. … Weissenbach J. (Nature 2003) 3 4 64
  2. Genomic structure and evolutionary context of the human feline leukemia virus subgroup C receptor (hFLVCR) gene: evidence for block duplications and de novo gene formation within duplicons of the hFLVCR locus. (PMID: 11943475) Lipovich L. … Quigley J.G. (Gene 2002) 2 3 64
  3. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9872452) Nagase T. … Ohara O. (DNA Res. 1998) 3 4 64
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  5. Tracking a refined eIF4E-binding motif reveals Angel1 as a new partner of eIF4E. (PMID: 23814182) Gosselin P. … Cosson B. (Nucleic Acids Res. 2013) 3 64

Products for ANGEL1 Gene

Sources for ANGEL1 Gene

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