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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ANG Gene

protein-coding   GIFtS: 62
GCID: GC14P021152

Angiogenin, Ribonuclease, RNase A Family, 5

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Angiogenin, Ribonuclease, RNase A Family, 51 2     RNASE42
RNASE52 3 5     angiogenin2
Ribonuclease 52 3     Epididymis Luminal Protein 1682
RNase 52 3     EC 3.1.27.-3
ALS92 5     EC 3.1.278
HEL1682     

External Ids:    HGNC: 4831   Entrez Gene: 2832   Ensembl: ENSG000002142747   OMIM: 1058505   UniProtKB: P039503   

Export aliases for ANG gene to outside databases

Previous GC identifers: GC14P018528 GC14P014944 GC14P019147 GC14P019143 GC14P019144 GC14P020223 GC14P001273


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ANG Gene:
The protein encoded by this gene is an exceedingly potent mediator of new blood vessel formation. It hydrolyzes
cellular tRNAs resulting in decreased protein synthesis and is similar to pancreatic ribonuclease. Alternative
splicing results in two transcript variants encoding the same protein. This gene and the gene that encodes
ribonuclease, RNase A family, 4 share promoters and 5' exons. Each gene splices to a unique downstream exon that
contains its complete coding region. (provided by RefSeq, Jul 2008)

GeneCards Summary for ANG Gene: 
ANG (angiogenin, ribonuclease, RNase A family, 5) is a protein-coding gene. Diseases associated with ANG include lipodermatosclerosis, and amyotrophic lateral sclerosis type 9. GO annotations related to this gene include actin binding and heparin binding. An important paralog of this gene is RNASE3.

UniProtKB/Swiss-Prot: ANGI_HUMAN, P03950
Function: Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and
translocated to the nucleus. Stimulates ribosomal RNA synthesis including that containing the initiation site
sequences of 45S rRNA. Cleaves tRNA within anticodon loops to produce tRNA-derived stress-induced fragments
(tiRNAs) which inhibit protein synthesis and triggers the assembly of stress granules (SGs). Angiogenin induces
vascularization of normal and malignant tissues. Angiogenic activity is regulated by interaction with RNH1 in
vivo

Gene Wiki entry for ANG (Angiogenin) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NC_018925.2  NT_026437.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ANG gene promoter:
         COUP-TF1   COUP-TF   COUP   HNF-4alpha2   Nkx2-5   HNF-4alpha1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ANG promoter sequence
   Search SABiosciences Chromatin IP Primers for ANG

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ANG


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q11.1-q11.2   Ensembl cytogenetic band:  14q11.2   HGNC cytogenetic band: 14q11.1-q11.2

ANG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ANG gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P021152:  view genomic region     (about GC identifiers)

Start:
21,152,336 bp from pter      End:
21,167,130 bp from pter
Size:
14,795 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ANGI_HUMAN, P03950 (See protein sequence)
Recommended Name: Angiogenin precursor  
Size: 147 amino acids; 16550 Da
Subunit: Interacts with and forms a tight 1:1 complex with RNH1. Dimerization of two such complexes may occur
Subcellular location: Secreted, extracellular space, extracellular matrix, basement membrane. Nucleus, nucleolus.
Note=Rapidly endocytosed by target cells and translocated to the nucleus where it accumulates in the nucleolus
and binds to DNA
Developmental stage: Low level expression in the developing fetus, increased in the neonate, and maximal in the
adult
Caution: It is uncertain whether Met-1 or Met-3 is the initiator
Sequence caution: Sequence=AAH20704.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
6/32 PDB 3D structures from and Proteopedia for ANG (see all 32):
1A4Y (3D)        1ANG (3D)        1AWZ (3D)        1B1E (3D)        1B1I (3D)        1B1J (3D)    
Secondary accessions: Q05CV1 Q53X86 Q6P5T2 Q8WXE7

Explore the universe of human proteins at neXtProt for ANG: NX_P03950

Explore proteomics data for ANG at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P03950

  • 4/11 DME Specific Peptides for ANG (P03950) (see all 11)
     PPTLAQD  LGLGLTP  FQVTTCK  PTLAQDN 

    ANG Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ANG Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001091046.1  NP_001136.1  

    ENSEMBL proteins: 
     ENSP00000336762   ENSP00000381077  

    Human Recombinant Protein Products for ANG: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for ANG (Angiogenin)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for ANG
    OriGene Protein Over-expression Lysate for ANG
    OriGene MassSpec for ANG 
    OriGene Custom Protein Services for ANG
    GenScript Custom Purified and Recombinant Proteins Services for ANG
    Novus Biologicals ANG Protein
    Novus Biologicals ANG Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ANG 

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005605basal lamina IDA15166501
    GO:0005615extracellular space IDA16461950
    GO:0005634nucleus IDA10649442
    GO:0005730nucleolus ISS--
    GO:0030426growth cone ISS--

    ANG for ontologies           About GeneDecksing



    ANG Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of ANG
    R&D Systems Antibodies for ANG (Angiogenin)
    Browse OriGene Antibodies
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    Novus Biologicals ANG Antibodies
    Abcam antibodies for ANG
    Cloud-Clone Corp. Antibodies for ANG 
    ThermoFisher Antibodies for ANG
    LSBio Antibodies in human, mouse, rat for ANG 

    Assay Products for ANG: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ANG
    R&D Systems ELISAs for ANG (Angiogenin)         (see all)
    GenScript Custom Assay Services for ANG
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ANG 
    Cloud-Clone Corp. CLIAs for ANG


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    RNASE: Ribonucleases, RNase A

    3 InterPro protein domains:
     IPR023411 RNaseA_AS
     IPR023412 RNaseA_domain
     IPR001427 RNaseA

    Graphical View of Domain Structure for InterPro Entry P03950

    ProtoNet protein and cluster: P03950

    1 Blocks protein domain: IPB001427 Pancreatic ribonuclease

    UniProtKB/Swiss-Prot: ANGI_HUMAN, P03950
    Similarity: Belongs to the pancreatic ribonuclease family


    ANG for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ANGI_HUMAN, P03950
    Function: Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and
    translocated to the nucleus. Stimulates ribosomal RNA synthesis including that containing the initiation site
    sequences of 45S rRNA. Cleaves tRNA within anticodon loops to produce tRNA-derived stress-induced fragments
    (tiRNAs) which inhibit protein synthesis and triggers the assembly of stress granules (SGs). Angiogenin induces
    vascularization of normal and malignant tissues. Angiogenic activity is regulated by interaction with RNH1 in
    vivo

         Genatlas biochemistry entry for ANG:
    angiogenin,ribonuclease RNAse A family

         Enzyme Numbers (IUBMB): EC 3.1.272 EC 3.1.27.-1

         Gene Ontology (GO): 5/11 molecular function terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IC10649442
    GO:0003779actin binding IDA11782452
    GO:0004519endonuclease activity TAS10103013
    GO:0004522pancreatic ribonuclease activity IEA--
    GO:0004540ribonuclease activity IDA2424496
         
    ANG for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ANG 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ANG

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ANG 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ANG 

    miRNA
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    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate ANG
    SwitchGear 3'UTR luciferase reporter plasmidANG 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ANG
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ANG

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for ANG
    Sirion Biotech Customized adenovirus for overexpression of ANG

    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): ANG (NM_001145)
    Sino Biological Human cDNA Clone for ANG
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ANG
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ANG
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                         Customized lentivirus expression plasmids for stable overexpression of ANG 

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    Search LifeMap BioReagents cell lines for ANG
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANG


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ANG

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    5/12 Interacting proteins for ANG (P039501, 3 ENSP000003367624) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ACTN2P356091, 3, ENSP000003555374EBI-525291,EBI-77797 I2D: score=3 STRING: ENSP00000355537
    FSTP198831, 3, ENSP000002567594EBI-525291,EBI-1571188 I2D: score=1 STRING: ENSP00000256759
    RNH1P134891, 3, ENSP000003464024EBI-525291,EBI-1237106 I2D: score=4 STRING: ENSP00000346402
    PTENP604843, ENSP000003610214I2D: score=4 STRING: ENSP00000361021
    TDGF1P133853, ENSP000002961454I2D: score=3 STRING: ENSP00000296145
    About this table

    Gene Ontology (GO): 5/21 biological process terms (GO ID links to tree view) (see all 21):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis TAS16567967
    GO:0001541ovarian follicle development NAS12770725
    GO:0001556oocyte maturation NAS11438326
    GO:0001666response to hypoxia NAS15776477
    GO:0001890placenta development NAS11984825

    ANG for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ANG for compounds           About GeneDecksing

    EMD Millipore small molecules for ANG:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ANG (ANGI)

    3 DrugBank Compounds for ANG    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Citric Acid-- 77-92-9target--17139284 17016423
    Pyroglutamic Acid-- 98-79-3target--17139284 17016423
    Pyrophosphate 2--- --target--17139284 17016423

    10/11 Novoseek inferred chemical compound relationships for ANG gene (see all 11)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    vegf 74.9 99 16490744 (10), 17093399 (7), 9815846 (5), 17493367 (4) (see all 42)
    2',5'-adp 64.4 1 14503864 (1)
    pd123319 53.5 3 17893372 (1), 9756092 (1), 15221345 (1)
    pyrimidine 44.7 8 14503864 (1), 9918722 (1), 7708754 (1), 11468363 (1) (see all 5)
    losartan 37.4 6 10484544 (2), 9051351 (1), 17893372 (1), 15221345 (1) (see all 5)
    phosphonate 30.3 1 14503864 (1)
    neomycin 15.4 4 19258415 (1), 19276260 (1)
    tyrosine 3.25 4 11348889 (1), 19787198 (1), 10397264 (1), 12010571 (1)
    hydrogen 0.351 1 11468363 (1)
    oxygen 0 1 17893372 (1)

    Search CenterWatch for drugs/clinical trials and news about ANG / ANGI

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ANG gene (2 alternative transcripts): 
    NM_001097577.2  NM_001145.4  

    Unigene Cluster for ANG:

    Angiogenin, ribonuclease, RNase A family, 5
    Hs.283749  [show with all ESTs]
    Unigene Representative Sequence: NM_002937
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000336811(uc001vxw.4) ENST00000554073 ENST00000397990(uc001vxz.3)


    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ANG
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate ANG
    SwitchGear 3'UTR luciferase reporter plasmidANG 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ANG
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ANG
    Clone
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    OriGene clones in human, mouse for ANG (see all 13)
    OriGene ORF clones in mouse, rat for ANG
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): ANG (NM_001145)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ANG
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ANG
    Sirion Biotech Customized lentivirus for stable overexpression of ANG 
                         Customized lentivirus expression plasmids for stable overexpression of ANG 
    Primer
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    OriGene qPCR primer pairs and template standards for ANG
    OriGene qSTAR qPCR primer pairs in human, mouse for ANG
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ANG
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ANG

    Additional mRNA sequence: 

    AK092422.1 AK313989.1 BC015520.1 BC020704.1 BC054880.1 BC062698.1 BX247985.1 BX248010.1 
    CR407633.1 D37931.1 FJ236304.1 

    8 DOTS entries:

    DT.319153  DT.97763017  DT.100803611  DT.101979535  DT.95372717  DT.319155  DT.95274406  DT.91745439 

    24/333 AceView cDNA sequences (see all 333):

    CR622207 CB215920 CR407633 CB161736 BM980362 AI934356 BQ773849 AA424174 
    AV646929 BM800182 CA447209 CR597178 BM785359 BU620311 AA999895 CF528880 
    AA635528 CR623403 AA577012 AA317789 BG618620 BF509059 AA418935 BG566891 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ANG expression in normal human tissues (normalized intensities)      ANG embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTAATAAAT
    ANG Expression
    About this image


    ANG expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/12 selected tissues (see all 12) fully expand
     
     Kidney (Urinary System)    fully expand to see all 2 entries
             Renal Collecting Duct System
     
     Placenta (Extraembryonic Tissues)    fully expand to see all 2 entries
             Villous Cytotrophoblast Cells Chorionic Villus
     
     Colon (Gastrointestinal Tract)
             rectum   
     
     Bone (Muscoskeletal System)
             Notch-transfected mesenchymal stromal cells (SB623)
     
     Uterus (Reproductive System)
             cervix   

    See ANG Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ANG

    SOURCE GeneReport for Unigene cluster: Hs.283749

    UniProtKB/Swiss-Prot: ANGI_HUMAN, P03950
    Tissue specificity: Expressed predominantly in the liver. Also detected in endothelial cells and spinal cord
    neurons

        SABiosciences Expression via Pathway-Focused PCR Arrays including ANG: 
              Insulin Signaling Pathway in human mouse rat
              Angiogenic Growth Factors in human mouse rat
              Angiogenesis in human mouse rat

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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ANG
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANG

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for ANG gene from 2/6 species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ang1 , 5 angiogenin, ribonuclease, RNase A family, 51, 5 82.98(n)1
    74.83(a)1
      14 (26.37 cM)5
    117271  NM_001161731.21  NP_001155203.11 
     510910775 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 6)
    Uncharacterized protein
    (see all 6)
    43(a)
    41(a)
    (see all 6)
    1 ↔ many
    1 ↔ many
    (see all 6)
    GL343220.1(1449001-1449435)
    GL343220.1(1519672-1520085)


    ENSEMBL Gene Tree for ANG (if available)
    TreeFam Gene Tree for ANG (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ANG gene
    RNASE32  RNASE82  RNASE72  RNASE22  RNASE12  RNASE62  RNASE42  
    2 SIMAP similar genes for ANG using alignment to 1 protein entry:     ANGI_HUMAN:
    RNASE1    RNASE4

    ANG for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/24 SNPs in ANG are shown (see all 24)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0441574
    Amyotrophic lateral sclerosis 9 (ALS9)4--see VAR_0441572 H R mis40--------
    VAR_0441514
    Amyotrophic lateral sclerosis 9 (ALS9)4--see VAR_0441512 R K mis40--------
    VAR_0441494
    Amyotrophic lateral sclerosis 9 (ALS9)4--see VAR_0441492 K I mis40--------
    VAR_0441464
    Amyotrophic lateral sclerosis 9 (ALS9)4--see VAR_0441462 P S mis40--------
    VAR_0441524
    Amyotrophic lateral sclerosis 9 (ALS9)4--see VAR_0441522 C W mis40--------
    VAR_0441554
    Amyotrophic lateral sclerosis 9 (ALS9)4--see VAR_0441552 P L mis40--------
    VAR_0441534
    Amyotrophic lateral sclerosis 9 (ALS9)4--see VAR_0441532 K I mis40--------
    VAR_0441474
    Amyotrophic lateral sclerosis 9 (ALS9)4--see VAR_0441472 Q L mis40--------
    VAR_0441454
    Amyotrophic lateral sclerosis 9 (ALS9)4--see VAR_0441452 F S mis40--------
    VAR_0441504
    Amyotrophic lateral sclerosis 9 (ALS9)4--see VAR_0441502 S N mis40--------

    HapMap Linkage Disequilibrium report for ANG (21152336 - 21167130 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for ANG:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv1203CNV Loss18451855
    esv23438CNV Gain+Loss19812545


    Human Gene Mutation Database (HGMD): ANG
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 105850   
    OMIM disorders: 611895  
    UniProtKB/Swiss-Prot: ANGI_HUMAN, P03950
  • Amyotrophic lateral sclerosis 9 (ALS9) [MIM:611895]: A neurodegenerative disorder affecting upper motor
    neurons in the brain and lower motor neurons in the brain stem and spinal cord, resulting in fatal paralysis.
    Sensory abnormalities are absent. The pathologic hallmarks of the disease include pallor of the corticospinal
    tract due to loss of motor neurons, presence of ubiquitin-positive inclusions within surviving motor neurons, and
    deposition of pathologic aggregates. The etiology of amyotrophic lateral sclerosis is likely to be
    multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10% of the cases.
    Note=Disease susceptibility is associated with variations affecting the gene represented in this entry

  • 20/68 diseases for ANG (see all 68):    About MalaCards
    lipodermatosclerosis    amyotrophic lateral sclerosis type 9    ang-related amyotrophic lateral sclerosis    gestational trophoblastic tumor
    uterine carcinosarcoma    amyotrophic lateral sclerosis    bladder carcinoma    noma
    lateral sclerosis    myelodysplastic syndromes    proliferative diabetic retinopathy    endometrial carcinoma
    cervical intraepithelial neoplasia    pancreatitis    laryngeal carcinoma    cerebral infarction
    diabetic retinopathy    age related macular degeneration    macular degeneration    kaposi's sarcoma

    2 diseases from the University of Copenhagen DISEASES database for ANG:
    Amyotrophic lateral sclerosis     Cancer

    ANG for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/24 Novoseek inferred disease relationships for ANG gene (see all 24)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    amyotrophic lateral sclerosis 65.4 15 18852347 (2), 18087731 (2), 16501576 (2), 19363631 (1) (see all 11)
    neovascularization 60.4 11 14581357 (2), 19354288 (2), 19502452 (1), 9539780 (1) (see all 9)
    tumors 30.3 44 7831307 (5), 17493367 (3), 9539780 (2), 18832998 (2) (see all 22)
    aggressiveness 20.7 4 10353747 (1), 8665497 (1), 10206479 (1)
    cancer 19.7 25 12168899 (3), 10353747 (2), 19575937 (2), 12684892 (2) (see all 10)
    bladder carcinoma 18.1 3 10421268 (2), 15329320 (1)
    solid tumor 13.1 1 10421268 (1)
    endometrial carcinoma 9.51 1 15581949 (1)
    pancreatic cancer 8.35 22 8665497 (4), 10206479 (4), 10353747 (1)
    gastric carcinoma 4.73 6 15757533 (4), 16937522 (1)

    GeneTests: ANG
    GeneReviews: ANG
    Genetic Association Database (GAD): ANG
    Human Genome Epidemiology (HuGE) Navigator: ANG (79 documents)

    Export disorders for ANG gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ANG gene, integrated from 9 sources (see all 266):
    (articles sorted by number of sources associating them with ANG)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of new ANG gene mutations in a large cohort of Italian patients with amyotrophic lateral sclerosis. (PubMed id 18087731)1, 2, 4, 9 Gellera C.... Silani V. (2008)
    2. Angiogenin loss-of-function mutations in amyotrophic lateral sclerosis. (PubMed id 17886298)1, 2, 9 Wu D.... Hu G.-F. (2007)
    3. Mutations of the ANG gene in French patients with sporadic amyotrophic lateral sclerosis. (PubMed id 18852347)1, 4, 9 Paubel A....Vourc'h P. (2008)
    4. Binding of phosphate and pyrophosphate ions at the active site of human angiogenin as revealed by X-ray crystallography. (PubMed id 11468363)1, 2, 9 Leonidas D.D....Acharya K.R. (2001)
    5. Identification of novel Angiogenin (ANG) gene missense variants in German patients with amyotrophic lateral sclerosis. (PubMed id 19363631)1, 4, 9 FernA!ndez-Santiago R....Ludolph A. (2009)
    6. Characterization of human angiogenin variants implicated in amyotrophic lateral sclerosis. (PubMed id 17900154)1, 2, 9 Crabtree B.... Acharya K.R. (2007)
    7. Crystallographic studies on the role of the C-terminal segment of human angiogenin in defining enzymatic potency. (PubMed id 11851402)1, 2, 9 Leonidas D.D.... Acharya K.R. (2002)
    8. Refined crystal structures of native human angiogenin and two active site variants: implications for the unique functional properties of an enzyme involved in neovascularisation during tumour growth. (PubMed id 9918722)1, 2, 9 Leonidas D.D....Acharya K.R. (1999)
    9. [Genetic determinants of cardiovascular remodeling in Uzbek patients with essential hypertension] (PubMed id 19253715)1, 4, 9 Eliseeva M.R....Abdullaeva G.Z.h. (2009)
    10. A novel Angiogenin gene mutation in a sporadic patient with amyotrophic lateral sclerosis from southern Italy. (PubMed id 17703939)1, 2, 9 Conforti F.L....Quattrone A. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 283 HGNC: 483 AceView: ANG Ensembl:ENSG00000214274 euGenes: HUgn283
    ECgene: ANG H-InvDB: ANG

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ANG Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ANG Genetics and Cytogenetics in Oncology and Haematology
    R&D Systems' cytokine mini-reviews: Angiogeninhttp://www.rndsystems.com/molecule_detail.aspx?m=1054
    Functional Glycomics Gateway - Glycan Bindinghttp://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_other_803
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/ANG

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ANG gene:
    Search GeneIP for patents involving ANG

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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