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Aliases & Descriptions for ANG
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases ALS9 2 , 5 EC 3.1.27.- 3 HEL168 2 MGC22466 2 MGC71966 2 OTTHUMP00000164020 2 OTTHUMP00000164021 2 RNASE4 2 RNASE5 1 , 2 , 3 , 5
Descriptions RNase 5 3 Ribonuclease 5 3 angiogenin, ribonuclease, RNase A family, 5 2 epididymis luminal protein 168 2
Search outside databases for aliases for ANG genePrevious GC identifers: GC14P018528 GC14P014944 GC14P019147 GC14P019143 GC14P019144
Summaries for ANG (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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EntrezGene summary for ANG : The protein encoded by this gene is an exceedingly potent mediator of new blood vessel formation.It hydrolyzes cellular tRNAs resulting in decreased protein synthesis and is similar to pancreaticribonuclease. Alternative splicing results in two transcript variants encoding the same protein.This gene and the gene that encodes ribonuclease, RNase A family, 4 share promoters and 5'exons. Each gene splices to a unique downstream exon that contains its complete coding region.[provided by RefSeq] UniProtKB/Swiss-Prot: ANGI_HUMAN, P03950 Function : May function as a tRNA-specific ribonuclease that binds to actin on the surface ofendothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus, therebypromoting the endothelial invasiveness necessary for blood vessel formation. Angiogenin inducesvascularization of normal and malignant tissues. Abolishes protein synthesis by specificallyhydrolyzing cellular tRNAs
Gene Wiki entry for ANG (Angiogenin)
Genomic Location for ANG
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
SABiosciences )About This Section
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Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the ANG gene Entrez Gene cytogenetic band: 14q11.1-q11.2 Ensembl cytogenetic band: 14q11.2 HGNC cytogenetic band: 14q11.1-q11.2 ANG Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 14 GeneLoc Exon Structure
GeneLoc location for GC14P020223:
(about GC identifiers )
Start:
20,222,176 bp from pter
End:
20,232,185 bp from pter
Size:
10,010 bases
Orientation:
plus strand
RefSeq DNA sequence: NC_000014.7 NT_026437.11 Proteins for ANG
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: ANGI_HUMAN, P03950 (See
protein sequence )Recommended Name: Angiogenin precursor Size : 147 amino acids; 16550 Da
Subcellular location : Secreted
Developmental stage : Low level expression in the developing fetus, increased in the neonate, andmaximal in the adult
Caution : It is uncertain whether Met-1 or Met-3 is the initiator
PDB structures from and Proteopedia : 1A4Y (3D)
 1ANG (3D)
 1AWZ (3D)
 1B1E (3D)
 1B1I (3D)
 1B1J (3D)
 1GV7 (3D)
 1H0D (3D)
 1H52 (3D)
 1H53 (3D)
 1HBY (3D)
 1K58 (3D)
 1K59 (3D)
 1K5A (3D)
 1K5B (3D)
 1UN3 (3D)
 1UN4 (3D)
 1UN5 (3D)
 2ANG (3D)
 
Secondary accessions : Q8WXE7
REFSEQ proteins (2 alternative transcripts):
NP_001091046.1 NP_001136.1 ENSEMBL proteins: ENSP00000381074 ENSP00000381077 ENSP00000336762 Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 5/8 Gene Ontology (GO) cellular component terms (links to tree view) (see all 8
):
About this table Antibodies for ANG: Invitrogen Antibodies for ANG Millipore Mono- and Polyclonal Antibodies for the study of ANG Sigma-Aldrich Antibodies for ANG R&D Systems Antibodies for ANG (Angiogenin) Antibodies from Abcam (Angiogenin ), each with their Abpromise SM Monoclonal and Polyclonal Antibodies from Abnova (ANG ) Novus Biologicals Antibodies for ANG
Assays for ANG:
Protein
Domains/ Families for ANG(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry P03950 ProtoNet protein and cluster: P03950
1 Blocks protein family : IPB001427 Pancreatic ribonuclease UniProtKB/Swiss-Prot: ANGI_HUMAN, P03950 Similarity : Belongs to the pancreatic ribonuclease family
Gene Function for ANG
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
OriGene ,
Sigma-Aldrich , RNAi from
Sigma-Aldrich ,
RNAi Products ,
Clones , and
Q-PCR Products
from Invitrogen ,
Millipore ,
OriGene , and/or
Abnova ,
siRNAs from
Applied Biosystems ,
SYBR primers from OriGene ,
Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_001145 Applied Biosystems Silencer ® siRNAs for ANG Sigma-Aldrich siRNA and siRNA Panels for ANG Sigma-Aldrich shRNA Panels and shRNA for ANG Explore Sigma-Aldrich super-pooled esiRNAs                OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_001097577                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_001097577                                  untagged cDNA clones in CMV expression vector (see all 2 ): NM_001097577  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_001145 UniProtKB/Swiss-Prot: ANGI_HUMAN, P03950 Function : May function as a tRNA-specific ribonuclease that binds to actin on the surface ofendothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus, therebypromoting the endothelial invasiveness necessary for blood vessel formation. Angiogenin inducesvascularization of normal and malignant tissues. Abolishes protein synthesis by specificallyhydrolyzing cellular tRNAs Enzyme Number (IUBMB): EC 3.1.27.-
Genatlas biochemistry entry for ANG :angiogenin,ribonuclease RNAse A family 5/11 Gene Ontology (GO) molecular function terms (links to tree view) (see all 11
):
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Pathways & Interactions for ANG
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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Gene Network CentralTM Interacting Genes and Proteins Network for ANG 5/20 Interacting proteins for ANG (ENSP00000336762 3 P03950 1 ) via UniProtKB, MINT, and/or STRING (see all 20
)About this table 5/22 Gene Ontology (GO) biological process terms (links to tree view) (see all 22
):
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Drugs & Compounds for ANG (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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Browse Tocris compounds for ANG 7 Novoseek chemical compound relationships for ANG gene
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Transcripts for ANG(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from Invitrogen ,
Millipore , and/or
Abnova ,
siRNAs from Applied Biosystems ,
Sigma-Aldrich ,
shRNA from
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OriGene ,
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_001145 Sigma-Aldrich siRNA and siRNA Panels for ANG Sigma-Aldrich shRNA Panels and shRNA for ANG Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_001097577 NM_001145
REFSEQ mRNAs for ANG gene (2 alternative transcripts): NM_001097577.2 NM_001145.4
Applied Biosystems TaqMan ® Gene Expression Assays: NM_001097577 NM_001145
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_001097577                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_001097577                                  untagged cDNA clones in CMV expression vector (see all 2 ): NM_001097577  
Additional cDNA sequence: AK092422.1 AK313989.1 BC015520.1 BC020704.1 BC054880.1 BC062698.1 BX247985.1 BX248010.1 CR407633.1 CR597178.1 CR622207.1 CR623403.1 D37931.1 FJ236304.1
8 DOTS entries : DT.319153 DT.97763017 DT.100803611 DT.101979535 DT.95372717 DT.319155 DT.95274406 DT.91745439
24/333 AceView cDNA sequences (see all 333
):AA953339 BU552571 C20998 CK904582 BI759778 BG562878 NM_001145 CA449864 BM995510 BE856015 BG567799 BM800182 BM983165 AA341255 BG569248 CB162113 AI168617 BX247985 AA862345 CB157060 AI978618 CR622207 BG618620 AW338069
highest scoring ESTs for ANG :AV645350 T95016 AA424174 N24920 T29333 T58749 W74202 BF920924 BG777781 BM792893
Unigene Cluster for ANG: Angiogenin, ribonuclease, RNase A family, 5 Hs.283749 [show with all ESTs ] Unigene Representative Sequence: NM_002937 GeneLoc Exon Structure 3 Ensembl transcripts including schematic representations : ENST00000397987
ENST00000397990
ENST00000336811
Expression for ANG
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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ANG expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for ANG 1 / 2 / 3
3 probe-sets matching ANG gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: --SOURCE GeneReport for Unigene cluster: Hs.283749 Expression variation in blood from EXPOLDB for ANG
UniProtKB/Swiss-Prot: ANGI_HUMAN, P03950 Tissue specificity : Expressed predominantly in the liver. Also detected in endothelial cells andspinal cord neurons
Orthologs for ANG
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for ANG gene from 4 species
Organism
Gene
Locus
Description
Human Similarity
NCBI accessions
chimpanzee (Pan troglodytes)
ANG1
--
angiogenin, ribonuclease, RNase A family, 5
99.55(n) 99.32(a)
494026 NM_001009159.1 NP_001009159.1
cow (Bos taurus)
ANG1
--
angiogenin, ribonuclease, RNase A family, 5
78.87(n) 66.9(a)
777597 XM_001251258.1 XP_001251259.1
rat (Rattus norvegicus)
Ang11
--
angiogenin, ribonuclease A family, member 1
82.03(n) 75.89(a)
305843 NM_001006992.1 NP_001006993.1
mouse (Mus musculus)
Ang1 , 5
14 (18.00 cM) 5
angiogenin, ribonuclease, RNase A family, 51, 5
83.45(n) 1 74.83(a) 1
11727 1 NM_007447.2 1 NP_031473.1 1 AI385586 5 AK159966 5 (see all 8 )
About this table Species with no ortholog for ANG ENSEMBL Gene Tree for ANG Paralogs for ANG (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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Paralogs for ANG gene LOC643332 2 RNASE3 2 RNASE8 2 RNASE7 2 RNASE6 2 RNASE4 2 RNASE2 2 RNASE1 2
SNPs/Variants for ANG (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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--
Disorders & Mutations for ANG
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
Novoseek , PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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OMIM: 105850 disorders : 611895 UniProtKB/Swiss-Prot: ANGI_HUMAN, P03950
Defects in ANG are the cause of susceptibility to amyotrophic lateral sclerosis type 9(ALS9) [MIM:611895]. ALS is a degenerative disorder of motor neurons in the cortex, brain stem andspinal cord. ALS is characterized by muscular weakness and atrophy
10/24 Novoseek disease relationships for ANG gene (see all 24
)
Disease
Score
Articles
PubMed IDs for Articles with Shared Sentences (# sentences)
neovascularization
61.18
10
14581357 (2), 19354288 (2), 9539780 (1), 17900154 (1) (see all 8 )
amyotrophic lateral sclerosis
58.61
14
18852347 (2), 18087731 (2), 16501576 (2), 17703939 (1) (see all 10 )
tumors
31.76
41
7831307 (5), 17493367 (3), 9539780 (2), 18832998 (2) (see all 20 )
aggressiveness
23.90
4
10353747 (1), 8665497 (1), 10206479 (1)
cancer
21.98
23
12168899 (3), 10353747 (2), 12684892 (2), 11299848 (1) (see all 9 )
bladder carcinoma
20.37
3
10421268 (2), 15329320 (1)
solid tumor
16.27
1
10421268 (1)
endometrial carcinoma
12.19
1
15581949 (1)
pancreatic cancer
11.89
22
8665497 (4), 10206479 (4), 10353747 (1)
gastric carcinoma
7.36
6
15757533 (4), 16937522 (1)
About this table GeneTests: ANG Amyotrophic Lateral Sclerosis Human Gene Mutation Database : ANG Human Genome Epidemiology Navigator: ANG (60 documents)
Medical News for ANG (Possibly Related Articles in
Doctor's Guide )
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Publications for ANG (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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10/189 PubMed articles for ANG gene (see all 189
): Angiogenin loss-of-function mutations in amyotrophic lateral sclerosis. (PubMed id 17886298) 1, 3, 4 Wu D....Hu G.F. (2007) Binding of phosphate and pyrophosphate ions at the active site of human angiogenin as revealed by X-ray crystallography. (PubMed id 11468363) 1, 3, 4 Leonidas D.D....Acharya K.R. (2001) Identification of new ANG gene mutations in a large cohort of Italian patients with amyotrophic lateral sclerosis. (PubMed id 18087731) 1, 3, 4 Gellera C.... Silani V. (2008) Characterization of human angiogenin variants implicated in amyotrophic lateral sclerosis. (PubMed id 17900154) 1, 3, 4 Crabtree B....Acharya K.R. (2007) Crystallographic studies on the role of the C-terminal segment of human angiogenin in defining enzymatic potency. (PubMed id 11851402) 1, 3, 4 Leonidas D.D.... Acharya K.R. (2002) Refined crystal structures of native human angiogenin and two active site variants: implications for the unique functional properties of an enzyme involved in neovascularisation during tumour growth. (PubMed id 9918722) 1, 3, 4 Leonidas D.D....Acharya K.R. (1999) A novel Angiogenin gene mutation in a sporadic patient with amyotrophic lateral sclerosis from southern Italy. (PubMed id 17703939) 1, 3, 4 Conforti F.L....Quattrone A. (2008) Molecular recognition of human angiogenin by placental ribonuclease inhibitor -- an X-ray crystallographic study at 2.0-A resolution. (PubMed id 9311977) 1, 3, 4 Papageorgiou A.C.... Acharya K.R. (1997) Crystallographic studies on structural features that determine the enzymatic specificity and potency of human angiogenin: Thr44, Thr80, and residues 38-41. (PubMed id 14756559) 1, 3, 4 Holloway D.E.... Acharya K.R. (2004) The crystal structure of human angiogenin in complex with an antitumor neutralizing antibody. (PubMed id 12842050) 1, 3, 4 Chavali G.B.... Acharya K.R. (2003)
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Genome Databases showing ANG
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
and/or
H-InvDB )
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Other Databases showing ANG
(According to HUGE )
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--
Specialized Databases showing ANG (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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Name Description
ATLAS Chromosomes in Cancer entry for ANG Genetics and Cytogenetics in Oncology and Haematology R&D Systems' cytokine mini-reviews: Angiogenin http://www.rndsystems.com/molecule_detail.aspx?m=1054 Functional Glycomics Gateway - Glycan Binding http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_other_803 GeneReviews http://www.genetests.org/query?gene=ANG
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-- Services for ANG (Reagents available from Applied Biosystems , Antibodies and assays by Cell
Signaling Technology , Abcam , Novus Biologicals ,Sigma-Aldrich , R&D Systems , Millipore , Abnova , and/or Invitrogen , Clones available from OriGene ,and/or Invitrogen , Drugs and/or compounds by Sigma-Aldrich , Enzo Life Sciences , and/or Tocris Bioscience )About This Section
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Products for ANG:
Search Tocris compounds for ANG
Antibodies for ANG
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Aliases for ANG
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Drugs/Compounds for ANG
Expression for ANG
Function for ANG
Location for ANG
Medical News for ANG
Orthologs for ANG
Paralogs for ANG
Pathways/Interactions for ANG
Proteins for ANG
Publications for ANG
SNPs for ANG
Search Box for ANG
Services for ANG
Summaries for ANG
Technologies for ANG
Transcripts for ANG
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GeneCards Homepage - Last full update: 2 Jul 2009
Incremental update: 13 Oct 2009