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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ANG Gene

protein-coding   GIFtS: 61
GCID: GC14P021152

angiogenin, ribonuclease, RNase A family, 5
 Explore 72 diseases affiliated with
ANG via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ANG    

Aliases
for ANG gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Angiogenin, Ribonuclease, RNase A Family, 51 2     RNASE42
RNASE51 2 3 5     Angiogenin1
Ribonuclease 52 3     Epididymis Luminal Protein 1682
RNase 52 3     EC 3.1.27.-3
ALS92 5     EC 3.1.278
HEL1682     

External Ids:    HGNC: 4831   Entrez Gene: 2832   Ensembl: ENSG000002142747   OMIM: 1058505   UniProtKB: P039503   

Export aliases for ANG gene to outside databases

Previous GC identifers: GC14P018528 GC14P014944 GC14P019147 GC14P019143 GC14P019144 GC14P020223 GC14P001273


Summaries
for ANG gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for ANG:
The protein encoded by this gene is an exceedingly potent mediator of new blood vessel formation. It hydrolyzes
cellular tRNAs resulting in decreased protein synthesis and is similar to pancreatic ribonuclease. Alternative
splicing results in two transcript variants encoding the same protein. This gene and the gene that encodes
ribonuclease, RNase A family, 4 share promoters and 5' exons. Each gene splices to a unique downstream exon that
contains its complete coding region. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: ANGI_HUMAN, P03950
Function: May function as a tRNA-specific ribonuclease that abolishes protein synthesis by specifically hydrolyzing
cellular tRNAs. Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and
translocated to the nucleus. Angiogenin induces vascularization of normal and malignant tissues. Angiogenic activity
is regulated by interaction with RNH1 in vivo

Gene Wiki entry for ANG (Angiogenin)


Genomic Views
for ANG gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NC_018925.1  NT_026437.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ANG gene promoter:
         COUP-TF1   COUP-TF   COUP   HNF-4alpha2   Nkx2-5   HNF-4alpha1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ANG promoter sequence
   Search SABiosciences Chromatin IP Primers for ANG

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ANG


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q11.1-q11.2   Ensembl cytogenetic band:  14q11.2   HGNC cytogenetic band: 14q11.1-q11.2

ANG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ANG gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P021152:  view genomic region     (about GC identifiers)

Start:
 21,152,336 bp from pter      End:
 21,167,130 bp from pter
Size:
 14,795 bases      Orientation:
 plus strand

Proteins
for ANG gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ANGI_HUMAN, P03950 (See protein sequence)
Recommended Name: Angiogenin precursor  
Size: 147 amino acids; 16550 Da
Subunit: Interacts with and forms a tight 1:1 complex with RNH1. Dimerization of two such complexes may occur
Subcellular location: Secreted
Developmental stage: Low level expression in the developing fetus, increased in the neonate, and maximal in the adult
Caution: It is uncertain whether Met-1 or Met-3 is the initiator
Sequence caution: Sequence=AAH20704.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
6/32 PDB 3D structures from and Proteopedia for ANG (see all 32):
1A4Y (3D)        1ANG (3D)        1AWZ (3D)        1B1E (3D)        1B1I (3D)        1B1J (3D)    
Secondary accessions: Q05CV1 Q53X86 Q6P5T2 Q8WXE7

Explore the universe of human proteins at neXtProt for ANG: NX_P03950

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P03950

    • 4/11 DME Specific Peptides for ANG (P03950) (see all 11)
     PPTLAQD  LGLGLTP  FQVTTCK  PTLAQDN 

    ANG Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001091046.1  NP_001136.1  

    ENSEMBL proteins: 
     ENSP00000336762   ENSP00000381077  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for ANG (Angiogenin)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: ANG
    OriGene Protein Over-expression Lysate (see all 3): ANG
    OriGene Custom Protein Services for ANG 
    GenScript Custom Purified and Recombinant Proteins Services for ANG
    Novus Biologicals ANG Protein
    Novus Biologicals ANG Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for ANG

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005605basal lamina IDA15166501
    GO:0005615extracellular space IDA16490744
    GO:0005634nucleus IDA10649442
    GO:0005730nucleolus ISS--
    GO:0030426growth cone ISS--


    ANG for ontologies           About GeneDecksing



    ANG Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of ANG
    R&D Systems Antibodies for ANG (Angiogenin)
    Browse OriGene Antibodies
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    GenScript Custom Superior Antibodies Services for ANG
    Novus Biologicals ANG Antibodies
    Search for Antibodies for ANG at Abcam  
    Uscn Antibodies for ANG
    ThermoFisher Antibodies for ANG

    Assay Products for ANG: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    R&D Systems ELISAs for ANG (Angiogenin)         (see all)
    GenScript Custom Assay Services for ANG
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for ANG

    Protein Domains /
    Families
    for ANG gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ANG for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR023411 RNaseA_AS
     IPR023412 RNaseA_domain
     IPR001427 RNaseA

    Graphical View of Domain Structure for InterPro Entry P03950

    ProtoNet protein and cluster: P03950

    1 Blocks protein family: IPB001427 Pancreatic ribonuclease

    UniProtKB/Swiss-Prot: ANGI_HUMAN, P03950
    Similarity: Belongs to the pancreatic ribonuclease family


    Function
    for ANG gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: ANGI_HUMAN, P03950
    Function: May function as a tRNA-specific ribonuclease that abolishes protein synthesis by specifically hydrolyzing
    cellular tRNAs. Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and
    translocated to the nucleus. Angiogenin induces vascularization of normal and malignant tissues. Angiogenic activity
    is regulated by interaction with RNH1 in vivo

         Genatlas biochemistry entry for ANG:
    angiogenin,ribonuclease RNAse A family

    Enzyme Numbers (IUBMB): EC 3.1.272 EC 3.1.27.-1

    miRNA
    Products:            		 OriGene 3'-UTR Clone (see all 2): ANG
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ANG
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate ANG
    SwitchGear 3'UTR luciferase reporter plasmid: ANG 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ANG (see all 4)
    OriGene shRNA RFP: ANG
    OriGene siRNA: ANG
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ANG

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for ANG

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ANG (see all 5)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ANG (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): ANG (NM_001145)
    Sino Biological Human cDNA Clone for ANG
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ANG
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ANG 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for ANG
    Search LifeMap BioReagents cell lines for ANG

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANG

    Gene Ontology (GO): 5/11 molecular function terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IC10649442
    GO:0003779actin binding IDA7679494
    GO:0004519endonuclease activity TAS10103013
    GO:0004522pancreatic ribonuclease activity IEA--
    GO:0004540ribonuclease activity IDA2730651


    ANG for ontologies           About GeneDecksing



    Pathways & Interactions
    for ANG gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ANG

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    5/12 Interacting proteins for ANG (P039501, 3 ENSP000003367624) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ACTN2P356091, 3, ENSP000003555374EBI-525291,EBI-928705 I2D: score=3 STRING: ENSP00000355537
    FSTP198831, 3, ENSP000002567594EBI-525291,EBI-1571188 I2D: score=1 STRING: ENSP00000256759
    RNH1P134891, 3, ENSP000003464024EBI-525291,EBI-1237106 I2D: score=4 STRING: ENSP00000346402
    PTENP604843, ENSP000003610214I2D: score=4 STRING: ENSP00000361021
    TDGF1P133853, ENSP000002961454I2D: score=3 STRING: ENSP00000296145
    About this table

    Gene Ontology (GO): 5/21 biological process terms (GO ID links to tree view) (see all 21):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis TAS16567967
    GO:0001541ovarian follicle development NAS12770725
    GO:0001556oocyte maturation NAS11438326
    GO:0001666response to hypoxia NAS15776477
    GO:0001890placenta development NAS11984825


    ANG for ontologies           About GeneDecksing



    Drugs & Compounds
    for ANG gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ANG for compounds           About GeneDecksing

    EMD Millipore small molecules for ANG:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ANG

    3 DrugBank Compounds for ANG    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Citric Acid-- 77-92-9target--17139284 17016423
    Pyroglutamic Acid-- 98-79-3target--17139284 17016423
    Pyrophosphate 2--- --target--17139284 17016423

    10/11 Novoseek chemical compound relationships for ANG gene (see all 11)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    vegf 74.9 99 16490744 (10), 17093399 (7), 9815846 (5), 17493367 (4) (see all 42)
    2',5'-adp 64.4 1 14503864 (1)
    pd123319 53.5 3 17893372 (1), 9756092 (1), 15221345 (1)
    pyrimidine 44.7 8 14503864 (1), 9918722 (1), 7708754 (1), 11468363 (1) (see all 5)
    losartan 37.4 6 10484544 (2), 9051351 (1), 17893372 (1), 15221345 (1) (see all 5)
    phosphonate 30.3 1 14503864 (1)
    neomycin 15.4 4 19258415 (1), 19276260 (1)
    tyrosine 3.25 4 11348889 (1), 19787198 (1), 10397264 (1), 12010571 (1)
    hydrogen 0.351 1 11468363 (1)
    oxygen 0 1 17893372 (1)

    Search CenterWatch for drugs/clinical trials and news about ANG / ANGI 

    Transcripts
    for ANG gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ANG gene (2 alternative transcripts): 
    NM_001097577.2  NM_001145.4  

    Unigene Cluster for ANG:

    Angiogenin, ribonuclease, RNase A family, 5
    Hs.283749  [show with all ESTs]
    Unigene Representative Sequence: NM_002937
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000336811(uc001vxw.4) ENST00000554073 ENST00000397990(uc001vxz.3)


    miRNA
    Products:             		 OriGene 3'-UTR Clone (see all 2): ANG
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ANG
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate ANG
    SwitchGear 3'UTR luciferase reporter plasmid: ANG 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ANG (see all 4)
    OriGene shRNA RFP: ANG
    OriGene siRNA: ANG
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ANG
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ANG (see all 5)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ANG (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): ANG (NM_001145)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ANG
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ANG 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ANG
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ANG
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ANG
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ANG

    Additional cDNA sequence: 

    AK092422.1 AK313989.1 BC015520.1 BC020704.1 BC054880.1 BC062698.1 BX247985.1 BX248010.1 
    CR407633.1 D37931.1 FJ236304.1 

    8 DOTS entries:

    DT.319153  DT.97763017  DT.100803611  DT.101979535  DT.95372717  DT.319155  DT.95274406  DT.91745439 

    24/333 AceView cDNA sequences (see all 333):

    BF594383 AI685720 BG562878 CB154272 BG563237 AI934356 BU552571 AV646929 
    NM_194431 BX247985 BU682731 AA418935 AA862345 BU732659 BX248010 BQ013922 
    CR623403 BG618620 CB215920 BM825329 AA635528 CB157060 C20998 AA577012 

    GeneLoc Exon Structure


    Expression
    for ANG gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ANG expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTTAATAAAT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    ANG expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    PlacentaChorionic VillusVillous Cytotrophoblast CellsExtraembryonic Tissues, Placenta
    PlacentaExtravillous Cytotrophoblast LayerExtravillous Cytotrophoblast CellsExtraembryonic Tissues, Placenta
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See ANG Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ANG

    SOURCE GeneReport for Unigene cluster: Hs.283749

    UniProtKB/Swiss-Prot: ANGI_HUMAN, P03950
    Tissue specificity: Expressed predominantly in the liver. Also detected in endothelial cells and spinal cord neurons

        SABiosciences Expression via Pathway-Focused PCR Arrays including ANG: 
              Insulin Signaling Pathway in human mouse rat
              Angiogenic Growth Factors in human mouse rat
              Angiogenesis in human mouse rat

    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ANG
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANG

    Orthologs
    for ANG gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for ANG gene from 2/7 species (see all 7)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    lizard
    (Anolis carolinensis)    		 Reptilia --
    --
    (see all 6)    		 --
    		 41(a)
    41(a)
    (see all 6)    		 1 ↔ many
    1 ↔ many
    (see all 6)    		 GL343865.1(90873-91431)
    GL343220.1(1449001-1449435)
    zebrafish
    (Danio rerio)    		 Actinopterygii rnasel26
    rnasel36
    		 ribonuclease like 3
    		 34(a)
    30(a)
    		 many ↔ many
    many ↔ many
    		 22(6217650-6218836)
    14(40044381-40046544)


    ENSEMBL Gene Tree for ANG (if available)
    TreeFam Gene Tree for ANG (if available) 

    Paralogs
    for ANG gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ANG gene
    RNASE32  RNASE72  RNASE82  RNASE62  RNASE42  RNASE12  RNASE22  ENSG000002588182  
    2 SIMAP similar genes for ANG using alignment to 1 protein entry:     ANGI_HUMAN:
    RNASE1    RNASE4

    ANG for paralogs           About GeneDecksing



    Genomic Variants
    for ANG gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/253 NCBI SNPs in ANG are shown (see all 253)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 14 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1219095361,2
    		C,F,pathogenic1282764(+) TGCCAA/TACCAC 4 K I mis12Minor allele frequency- T:0.00NA EU 5875
    rs1219095411,2
    		C,Fpathogenic1282850(+) CATTTA/GTTCAT 4 I V mis11Minor allele frequency- G:0.00NA 4552
    rs1219095431,2
    		Cpathogenic1283049(+) CTTACC/TTGTCC 4 P L mis11Minor allele frequency- T:0.00NA 4550
    rs726599721,2
    		C,--1271740(+) CTCTTC/TCCCCC 1 -- us2k10--------
    rs171146331,2
    		C,F,H,--1272271(+) CTTTCC/TGGGTA 1 -- us2k111Minor allele frequency- T:0.04NA NS EA WA 1348
    rs735722971,2
    		C,--1272339(+) AGGAGA/CGTTGT 1 -- us2k12Minor allele frequency- C:0.03WA 120
    rs777538141,2
    		--1272349(+) TTTCCG/ATGCTT 1 -- us2k12Minor allele frequency- A:0.02CSA WA 120
    rs756683941,2
    		F,--1272491(+) AAAAAA/GTCTCT 1 -- us2k11Minor allele frequency- G:0.03NA 120
    rs791638621,2
    		--1272851(+) GGGCTC/TAGTGA 1 -- us2k11Minor allele frequency- T:0.01WA 118
    rs789376651,2
    		F,--1273072(+) AGAGTG/AATAGG 1 -- us2k11Minor allele frequency- A:0.03NA 120

    HapMap Linkage Disequilibrium report for ANG (21152336 - 21167130 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 5 variations for ANG
         5 CNVs: 87129 76571 87130 76570 71865
    Human Gene Mutation Database (HGMD): ANG

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    DNA2.0 Custom Variant and Variant Library Synthesis for ANG

    Disorders / Diseases
    for ANG gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ANG for disorders           About GeneDecksing

    OMIM gene information: 105850   
    OMIM disorders: 611895  
    UniProtKB/Swiss-Prot: ANGI_HUMAN, P03950
  • Defects in ANG are the cause of susceptibility to amyotrophic lateral sclerosis type 9 (ALS9) [MIM:611895].
    • ALS is a degenerative disorder of motor neurons in the cortex, brain stem and spinal cord. ALS is characterized by
    muscular weakness and atrophy

    20/72 diseases for ANG (see all 72):    About MalaCards
    amyotrophic lateral sclerosis    amyotrophic lateral sclerosis type 9    age related macular degeneration    pancreatitis
    lateral sclerosis    gestational trophoblastic tumor    uterine carcinosarcoma    non-hodgkin lymphoma
    cervical intraepithelial neoplasia    proliferative diabetic retinopathy    macular degeneration    lipodermatosclerosis
    diabetic retinopathy    hodgkin's lymphoma    inflammatory bowel disease    myelodysplastic syndrome
    rheumatoid arthritis    chronic lymphocytic leukemia    acute myeloid leukemia    bladder carcinoma

    2 diseases from the University of Copenhagen DISEASES database for ANG:
    Amyotrophic lateral sclerosis     Cancer

    10/24 Novoseek disease relationships for ANG gene (see all 24)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    amyotrophic lateral sclerosis 65.4 15 18852347 (2), 18087731 (2), 16501576 (2), 19363631 (1) (see all 11)
    neovascularization 60.4 11 14581357 (2), 19354288 (2), 19502452 (1), 9539780 (1) (see all 9)
    tumors 30.3 44 7831307 (5), 17493367 (3), 9539780 (2), 18832998 (2) (see all 22)
    aggressiveness 20.7 4 10353747 (1), 8665497 (1), 10206479 (1)
    cancer 19.7 25 12168899 (3), 10353747 (2), 19575937 (2), 12684892 (2) (see all 10)
    bladder carcinoma 18.1 3 10421268 (2), 15329320 (1)
    solid tumor 13.1 1 10421268 (1)
    endometrial carcinoma 9.51 1 15581949 (1)
    pancreatic cancer 8.35 22 8665497 (4), 10206479 (4), 10353747 (1)
    gastric carcinoma 4.73 6 15757533 (4), 16937522 (1)

    GeneTests: ANG
    Amyotrophic Lateral Sclerosis

    Human Genome Epidemiology (HuGE) Navigator: ANG (79 documents)

    Export disorders for ANG gene to outside databases

    Publications
    for ANG gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ANG gene, integrated from 9 sources (see all 256):
    (articles sorted by number of sources associating them with ANG)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Angiogenin loss-of-function mutations in amyotrophic lateral sclerosis. (PubMed id 17886298)1, 2, 9 Wu D.... Hu G.-F. (2007)
    2. Binding of phosphate and pyrophosphate ions at the active site of human angiogenin as revealed by X-ray crystallography. (PubMed id 11468363)1, 2, 9 Leonidas D.D....Acharya K.R. (2001)
    3. Identification of new ANG gene mutations in a large cohort of Italian patients with amyotrophic lateral sclerosis. (PubMed id 18087731)1, 2, 9 Gellera C.... Silani V. (2008)
    4. Characterization of human angiogenin variants implicated in amyotrophic lateral sclerosis. (PubMed id 17900154)1, 2, 9 Crabtree B.... Acharya K.R. (2007)
    5. Crystallographic studies on the role of the C-terminal segment of human angiogenin in defining enzymatic potency. (PubMed id 11851402)1, 2, 9 Leonidas D.D.... Acharya K.R. (2002)
    6. Refined crystal structures of native human angiogenin and two active site variants: implications for the unique functional properties of an enzyme involved in neovascularisation during tumour growth. (PubMed id 9918722)1, 2, 9 Leonidas D.D....Acharya K.R. (1999)
    7. A novel Angiogenin gene mutation in a sporadic patient with amyotrophic lateral sclerosis from southern Italy. (PubMed id 17703939)1, 2, 9 Conforti F.L....Quattrone A. (2008)
    8. Superadditive and subadditive effects of 'hot spot' mutations within the interfaces of placental ribonuclease inhibitor with angiogenin and ribonuclease A. (PubMed id 10413501)1, 2, 9 Chen C.Z. and Shapiro R. (1999)
    9. Molecular recognition of human angiogenin by placental ribonuclease inhibitor -- an X-ray crystallographic study at 2.0-A resolution. (PubMed id 9311977)1, 2, 9 Papageorgiou A.C.... Acharya K.R. (1997)
    10. Crystallographic studies on structural features that determine the enzymatic specificity and potency of human angiogenin: Thr44, Thr80, and residues 38-41. (PubMed id 14756559)1, 2, 9 Holloway D.E.... Acharya K.R. (2004)

    External Searches for ANG gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
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    Genome Databases showing ANG gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 283 HGNC: 483 AceView: ANG Ensembl:ENSG00000214274 euGenes: HUgn283
    ECgene: ANG H-InvDB: ANG

    Other Databases showing ANG gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ANG gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ANG Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ANG Genetics and Cytogenetics in Oncology and Haematology
    R&D Systems' cytokine mini-reviews: Angiogeninhttp://www.rndsystems.com/molecule_detail.aspx?m=1054
    Functional Glycomics Gateway - Glycan Bindinghttp://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_other_803
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/ANG

    Intellectual Property
    for ANG gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ANG gene:
    Search GeneIP for patents involving ANG

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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