Aliases for ANG Gene
External Ids for ANG Gene
Previous GeneCards Identifiers for ANG Gene
The protein encoded by this gene is an exceedingly potent mediator of new blood vessel formation. It hydrolyzes cellular tRNAs resulting in decreased protein synthesis and is similar to pancreatic ribonuclease. In addition, the mature peptide has antimicrobial activity against some bacteria and fungi, including S. pneumoniae and C. albicans. Alternative splicing results in two transcript variants encoding the same protein. This gene and the gene that encodes ribonuclease, RNase A family, 4 share promoters and 5' exons. Each gene splices to a unique downstream exon that contains its complete coding region. [provided by RefSeq, Aug 2014]
GeneCards Summary for ANG Gene
ANG (Angiogenin, Ribonuclease, RNase A Family, 5) is a Protein Coding gene. Diseases associated with ANG include Amyotrophic Lateral Sclerosis 9 and Amyotrophic Lateral Sclerosis 1. Among its related pathways are Cell junction organization. GO annotations related to this gene include protein homodimerization activity and actin binding. An important paralog of this gene is RNASE1.
UniProtKB/Swiss-Prot for ANG Gene
Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus. Stimulates ribosomal RNA synthesis including that containing the initiation site sequences of 45S rRNA. Cleaves tRNA within anticodon loops to produce tRNA-derived stress-induced fragments (tiRNAs) which inhibit protein synthesis and triggers the assembly of stress granules (SGs). Angiogenin induces vascularization of normal and malignant tissues. Angiogenic activity is regulated by interaction with RNH1 in vivo.