Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



ANG Gene

protein-coding   GIFtS: 63
GCID: GC14P021152

Angiogenin, Ribonuclease, RNase A Family, 5

  See ANG-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Angiogenin, Ribonuclease, RNase A Family, 51 2     RNASE42
RNASE52 3 5     angiogenin2
Ribonuclease 52 3     Epididymis Luminal Protein 1682
RNase 52 3     Ribonuclease A A12
ALS92 5     EC 3.1.27.-3
HEL1682     EC 3.1.278
RAA12     

External Ids:    HGNC: 4831   Entrez Gene: 2832   Ensembl: ENSG000002142747   OMIM: 1058505   UniProtKB: P039503   
ORGUL members:         

Export aliases for ANG gene to outside databases

Previous GC identifers: GC14P018528 GC14P014944 GC14P019147 GC14P019143 GC14P019144 GC14P020223 GC14P001273


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for ANG Gene:
The protein encoded by this gene is an exceedingly potent mediator of new blood vessel formation. It hydrolyzes
cellular tRNAs resulting in decreased protein synthesis and is similar to pancreatic ribonuclease. Alternative
splicing results in two transcript variants encoding the same protein. This gene and the gene that encodes
ribonuclease, RNase A family, 4 share promoters and 5' exons. Each gene splices to a unique downstream exon that
contains its complete coding region. (provided by RefSeq, Jul 2008)

GeneCards Summary for ANG Gene:
ANG (angiogenin, ribonuclease, RNase A family, 5) is a protein-coding gene. Diseases associated with ANG include lipodermatosclerosis, and ang-related amyotrophic lateral sclerosis. GO annotations related to this gene include actin binding and heparin binding. An important paralog of this gene is RNASE3.

UniProtKB/Swiss-Prot: ANGI_HUMAN, P03950
Function: Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and
translocated to the nucleus. Stimulates ribosomal RNA synthesis including that containing the initiation site
sequences of 45S rRNA. Cleaves tRNA within anticodon loops to produce tRNA-derived stress-induced fragments
(tiRNAs) which inhibit protein synthesis and triggers the assembly of stress granules (SGs). Angiogenin induces
vascularization of normal and malignant tissues. Angiogenic activity is regulated by interaction with RNH1 in
vivo

Gene Wiki entry for ANG (Angiogenin) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000014.8  NC_018925.2  NT_026437.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the ANG gene promoter:
         COUP-TF1   COUP-TF   COUP   HNF-4alpha2   Nkx2-5   HNF-4alpha1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ANG promoter sequence
   Search Chromatin IP Primers for ANG

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ANG


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q11.1-q11.2   Ensembl cytogenetic band:  14q11.2   HGNC cytogenetic band: 14q11.1-q11.2

ANG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ANG gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P021152:  view genomic region     (about GC identifiers)

Start:
21,152,336 bp from pter      End:
21,167,130 bp from pter
Size:
14,795 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: ANGI_HUMAN, P03950 (See protein sequence)
Recommended Name: Angiogenin precursor  
Size: 147 amino acids; 16550 Da
Subunit: Interacts with and forms a tight 1:1 complex with RNH1. Dimerization of two such complexes may occur
Developmental stage: Low level expression in the developing fetus, increased in the neonate, and maximal in the
adult
Caution: It is uncertain whether Met-1 or Met-3 is the initiator
Sequence caution: Sequence=AAH20704.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Selected PDB 3D structures from and Proteopedia for ANG (see all 32):
1A4Y (3D)        1ANG (3D)        1AWZ (3D)        1B1E (3D)        1B1I (3D)        1B1J (3D)    
Secondary accessions: Q05CV1 Q53X86 Q6P5T2 Q8WXE7

Explore the universe of human proteins at neXtProt for ANG: NX_P03950

Explore proteomics data for ANG at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for ANG (P03950) (see all 11)
     PPTLAQD  LGLGLTP  FQVTTCK  PTLAQDN 


    See ANG Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001091046.1  NP_001136.1  

    ENSEMBL proteins: 
     ENSP00000336762   ENSP00000381077  

    ANG Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for ANG (Angiogenin)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for ANG
    OriGene Protein Over-expression Lysate for ANG
    OriGene MassSpec for ANG
    OriGene Custom Protein Services for ANG
    GenScript Custom Purified and Recombinant Proteins Services for ANG
    Novus Biologicals ANG Protein
    Novus Biologicals ANG Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ANG

     
    Search eBioscience for Proteins for ANG 

     
    antibodies-online proteins for ANG (35 products) 

     
    antibodies-online peptides for ANG

    ANG Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of ANG
    R&D Systems Antibodies for ANG (Angiogenin)
    OriGene Antibodies for ANG
    OriGene Custom Antibody Services for ANG
    Novus Biologicals ANG Antibodies
    Abcam antibodies for ANG
    Cloud-Clone Corp. Antibodies for ANG
    ThermoFisher Antibodies for ANG
    LSBio Antibodies in human, mouse, rat for ANG
    antibodies-online antibodies for ANG (53 products) 

    ANG Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ANG
    R&D Systems ELISAs for ANG (Angiogenin)         (see all)
    GenScript Custom Assay Services for ANG
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ANG
    Cloud-Clone Corp. CLIAs for ANG
    Search eBioscience for ELISAs for ANG 
    antibodies-online kits for ANG (55 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    RNASE: Ribonucleases, RNase A

    3 InterPro protein domains:
     IPR023411 RNaseA_AS
     IPR001427 RNaseA
     IPR023412 RNaseA_domain

    Graphical View of Domain Structure for InterPro Entry P03950

    ProtoNet protein and cluster: P03950

    1 Blocks protein domain: IPB001427 Pancreatic ribonuclease

    UniProtKB/Swiss-Prot: ANGI_HUMAN, P03950
    Similarity: Belongs to the pancreatic ribonuclease family


    Find genes that share domains with ANG           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ANGI_HUMAN, P03950
    Function: Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and
    translocated to the nucleus. Stimulates ribosomal RNA synthesis including that containing the initiation site
    sequences of 45S rRNA. Cleaves tRNA within anticodon loops to produce tRNA-derived stress-induced fragments
    (tiRNAs) which inhibit protein synthesis and triggers the assembly of stress granules (SGs). Angiogenin induces
    vascularization of normal and malignant tissues. Angiogenic activity is regulated by interaction with RNH1 in
    vivo

         Genatlas biochemistry entry for ANG:
    angiogenin,ribonuclease RNAse A family

         Enzyme Numbers (IUBMB): EC 3.1.272 EC 3.1.27.-1

         Gene Ontology (GO): Selected molecular function terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IC10649442
    GO:0003779actin binding IDA11782452
    GO:0004519endonuclease activity TAS10103013
    GO:0004540ribonuclease activity IDA2424496
    GO:0005102receptor binding IDA9122172
         
    Find genes that share ontologies with ANG           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ANG
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ANG

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ANG
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ANG

    miRNA
    Products:
        
    miRTarBase miRNAs that target ANG:
    hsa-mir-335-5p (MIRT018344), hsa-mir-409-3p (MIRT006649), hsa-mir-192-5p (MIRT026610), hsa-mir-215-5p (MIRT024617)

    Block miRNA regulation of human, mouse, rat ANG using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate ANG
    SwitchGear 3'UTR luciferase reporter plasmidANG 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ANG
    Predesigned siRNA for gene silencing in human, mouse, rat ANG

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ANG

    Clone
    Products:
         
    OriGene clones in human, mouse for ANG (see all 12)
    OriGene ORF clones in mouse, rat for ANG
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): ANG (NM_001145)
    Sino Biological Human cDNA Clone for ANG
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ANG
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ANG

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ANG
    Browse ESI BIO Cell Lines and PureStem Progenitors for ANG 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANG


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    ANGI_HUMAN, P03950: Secreted, extracellular space, extracellular matrix, basement membrane. Nucleus, nucleolus.
    Note=Rapidly endocytosed by target cells and translocated to the nucleus where it accumulates in the nucleolus
    and binds to DNA
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    nucleus5
    cytoskeleton1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005605basal lamina IDA15166501
    GO:0005615extracellular space IDA16461950
    GO:0005634nucleus IDA10649442
    GO:0005730nucleolus ISS--
    GO:0030426growth cone ISS--

    Find genes that share ontologies with ANG           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus




        Pathway & Disease-focused RT2 Profiler PCR Arrays including ANG: 
              Insulin Signaling Pathway in human mouse rat
              Angiogenic Growth Factors in human mouse rat
              Angiogenesis in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for ANG

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    Selected Interacting proteins for ANG (P039501, 3 ENSP000003367624) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ACTN2P356091, 3, ENSP000003555374EBI-525291,EBI-77797 I2D: score=3 STRING: ENSP00000355537
    FSTP198831, 3, ENSP000002567594EBI-525291,EBI-1571188 I2D: score=1 STRING: ENSP00000256759
    RNH1P134891, 3, ENSP000003464024EBI-525291,EBI-1237106 I2D: score=4 STRING: ENSP00000346402
    PTENP604843, ENSP000003610214I2D: score=4 STRING: ENSP00000361021
    TDGF1P133853, ENSP000002961454I2D: score=3 STRING: ENSP00000296145
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 23):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis TAS16567967
    GO:0001541ovarian follicle development NAS12770725
    GO:0001556oocyte maturation NAS11438326
    GO:0001666response to hypoxia NAS15776477
    GO:0001890placenta development NAS11984825

    Find genes that share ontologies with ANG           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ANG (ANGI)

    3 DrugBank Compounds for ANG    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Citric Acid-- 77-92-9target--17139284 17016423
    Pyroglutamic Acid-- 98-79-3target--17139284 17016423
    Pyrophosphate 2--- --target--17139284 17016423

    Selected Novoseek inferred chemical compound relationships for ANG gene (see all 11)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    vegf 74.9 99 16490744 (10), 17093399 (7), 9815846 (5), 17493367 (4) (see all 42)
    2',5'-adp 64.4 1 14503864 (1)
    pd123319 53.5 3 17893372 (1), 9756092 (1), 15221345 (1)
    pyrimidine 44.7 8 14503864 (1), 9918722 (1), 7708754 (1), 11468363 (1) (see all 5)
    losartan 37.4 6 10484544 (2), 9051351 (1), 17893372 (1), 15221345 (1) (see all 5)
    phosphonate 30.3 1 14503864 (1)
    neomycin 15.4 4 19258415 (1), 19276260 (1)
    tyrosine 3.25 4 11348889 (1), 19787198 (1), 10397264 (1), 12010571 (1)
    hydrogen 0.351 1 11468363 (1)
    oxygen 0 1 17893372 (1)



    Find genes that share compounds with ANG           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for ANG gene (2 alternative transcripts): 
    NM_001097577.2  NM_001145.4  

    Unigene Cluster for ANG:

    Angiogenin, ribonuclease, RNase A family, 5
    Hs.283749  [show with all ESTs]
    Unigene Representative Sequence: NM_002937
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000336811(uc001vxw.4) ENST00000554073 ENST00000397990(uc001vxz.3)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ANG using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate ANG
    SwitchGear 3'UTR luciferase reporter plasmidANG 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ANG
    Predesigned siRNA for gene silencing in human, mouse, rat ANG
    Clone
    Products:
         
    OriGene clones in human, mouse for ANG (see all 12)
    OriGene ORF clones in mouse, rat for ANG
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): ANG (NM_001145)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ANG
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ANG
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for ANG
    OriGene qSTAR qPCR primer pairs in human, mouse for ANG
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ANG
      QuantiTect SYBR Green Assays in human, mouse, rat ANG
      QuantiFast Probe-based Assays in human, mouse, rat ANG

    Additional mRNA sequence: 

    AK092422.1 AK313989.1 BC015520.1 BC020704.1 BC054880.1 BC062698.1 BX247985.1 BX248010.1 
    CR407633.1 D37931.1 FJ236304.1 

    8 DOTS entries:

    DT.319153  DT.97763017  DT.100803611  DT.101979535  DT.95372717  DT.319155  DT.95274406  DT.91745439 

    Selected AceView cDNA sequences (see all 333):

    CR623403 BG566959 CR622207 BM054905 T29333 CA449864 CB215920 AI335730 
    AI978618 CA447209 BG563237 CR597178 BG567799 R28749 AA317789 CF528880 
    AA341255 BE856015 BM800182 NM_194430 BG564488 CK904582 BM983165 AA577012 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    ANG expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTAATAAAT
    ANG Expression
    About this image


    ANG expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Blood (Cardiovascular System)    fully expand to see all 3 entries
             Monocytes Peripheral Blood
             Angiogenic cell precursor
     
     Endothelium (Cardiovascular System)
             Angiogenic cell precursor
     
     Kidney (Urinary System)    fully expand to see all 2 entries
             Renal Collecting Duct System
     
     Placenta (Extraembryonic Tissues)    fully expand to see all 2 entries
             Villous Cytotrophoblast Cells Chorionic Villus
     
     Pancreas (Endocrine System)
             Islets of Langerhans
    ANG Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ANG Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.283749

    UniProtKB/Swiss-Prot: ANGI_HUMAN, P03950
    Tissue specificity: Expressed predominantly in the liver. Also detected in endothelial cells and spinal cord
    neurons

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ANG: 
              Insulin Signaling Pathway in human mouse rat
              Angiogenic Growth Factors in human mouse rat
              Angiogenesis in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for ANG
    OriGene qSTAR qPCR primer pairs in human, mouse for ANG
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ANG
    QuantiTect SYBR Green Assays in human, mouse, rat ANG
    QuantiFast Probe-based Assays in human, mouse, rat ANG
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANG

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for ANG gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ang1 , 5 angiogenin, ribonuclease, RNase A family, 51, 5 83.87(n)1
    79.03(a)1
      14 (26.37 cM)5
    117271  NM_001161731.21  NP_001155203.11 
     510910775 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 6)
    Uncharacterized protein
    (see all 6)
    44(a)
    43(a)
    (see all 6)
    1 ↔ many
    1 ↔ many
    (see all 6)
    GL343220.1(1449001-1449435)
    GL343220.1(1502216-1502641)


    ENSEMBL Gene Tree for ANG (if available)
    TreeFam Gene Tree for ANG (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for ANG gene
    RNASE32  RNASE82  RNASE72  RNASE22  RNASE12  RNASE62  RNASE42  
    3 SIMAP similar genes for ANG using alignment to 1 protein entry:     ANGI_HUMAN:
    RNASE1    RAB1    RNASE4

    Find genes that share paralogs with ANG           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for ANG (see all 24)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0441574
    Amyotrophic lateral sclerosis 9 (ALS9)4--see VAR_0441572 H R mis40--------
    VAR_0441514
    Amyotrophic lateral sclerosis 9 (ALS9)4--see VAR_0441512 R K mis40--------
    VAR_0441494
    Amyotrophic lateral sclerosis 9 (ALS9)4--see VAR_0441492 K I mis40--------
    VAR_0441464
    Amyotrophic lateral sclerosis 9 (ALS9)4--see VAR_0441462 P S mis40--------
    VAR_0441524
    Amyotrophic lateral sclerosis 9 (ALS9)4--see VAR_0441522 C W mis40--------
    VAR_0441554
    Amyotrophic lateral sclerosis 9 (ALS9)4--see VAR_0441552 P L mis40--------
    VAR_0441534
    Amyotrophic lateral sclerosis 9 (ALS9)4--see VAR_0441532 K I mis40--------
    VAR_0441474
    Amyotrophic lateral sclerosis 9 (ALS9)4--see VAR_0441472 Q L mis40--------
    VAR_0441454
    Amyotrophic lateral sclerosis 9 (ALS9)4--see VAR_0441452 F S mis40--------
    VAR_0441504
    Amyotrophic lateral sclerosis 9 (ALS9)4--see VAR_0441502 S N mis40--------

    HapMap Linkage Disequilibrium report for ANG (21152336 - 21167130 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for ANG:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv1203CNV Loss18451855
    esv23438CNV Gain+Loss19812545

    Human Gene Mutation Database (HGMD): ANG
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ANG
    DNA2.0 Custom Variant and Variant Library Synthesis for ANG

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 105850   
    OMIM disorders: 611895  
    UniProtKB/Swiss-Prot: ANGI_HUMAN, P03950
  • Amyotrophic lateral sclerosis 9 (ALS9) [MIM:611895]: A neurodegenerative disorder affecting upper motor
    neurons in the brain and lower motor neurons in the brain stem and spinal cord, resulting in fatal paralysis.
    Sensory abnormalities are absent. The pathologic hallmarks of the disease include pallor of the corticospinal
    tract due to loss of motor neurons, presence of ubiquitin-positive inclusions within surviving motor neurons, and
    deposition of pathologic aggregates. The etiology of amyotrophic lateral sclerosis is likely to be
    multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10% of the cases.
    Note=Disease susceptibility is associated with variations affecting the gene represented in this entry

  • 11 diseases for ANG:    
    About MalaCards
    lipodermatosclerosis    ang-related amyotrophic lateral sclerosis    amyotrophic lateral sclerosis type 9    gestational trophoblastic tumor
    uterine carcinosarcoma    cutaneous t cell lymphoma    bladder carcinoma    amyotrophic lateral sclerosis
    endometrial carcinoma    myelodysplastic syndromes    pancreatic cancer

    2 diseases from the University of Copenhagen DISEASES database for ANG:
    Amyotrophic lateral sclerosis     Cancer

    Find genes that share disorders with ANG           About GenesLikeMe

    Selected Novoseek inferred disease relationships for ANG gene (see all 24)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    amyotrophic lateral sclerosis 65.4 15 18852347 (2), 18087731 (2), 16501576 (2), 19363631 (1) (see all 11)
    neovascularization 60.4 11 14581357 (2), 19354288 (2), 19502452 (1), 9539780 (1) (see all 9)
    tumors 30.3 44 7831307 (5), 17493367 (3), 9539780 (2), 18832998 (2) (see all 22)
    aggressiveness 20.7 4 10353747 (1), 8665497 (1), 10206479 (1)
    cancer 19.7 25 12168899 (3), 10353747 (2), 19575937 (2), 12684892 (2) (see all 10)
    bladder carcinoma 18.1 3 10421268 (2), 15329320 (1)
    solid tumor 13.1 1 10421268 (1)
    endometrial carcinoma 9.51 1 15581949 (1)
    pancreatic cancer 8.35 22 8665497 (4), 10206479 (4), 10353747 (1)
    gastric carcinoma 4.73 6 15757533 (4), 16937522 (1)

    GeneTests: ANG
    GeneReviews: ANG
    Genetic Association Database (GAD): ANG
    Human Genome Epidemiology (HuGE) Navigator: ANG (79 documents)

    Export disorders for ANG gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for ANG gene, integrated from 10 sources (see all 270):
    (articles sorted by number of sources associating them with ANG)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of new ANG gene mutations in a large cohort of Italian patients with amyotrophic lateral sclerosis. (PubMed id 18087731)1, 2, 4, 9 Gellera C.... Silani V. (Neurogenetics 2008)
    2. Angiogenin loss-of-function mutations in amyotrophic lateral sclerosis. (PubMed id 17886298)1, 2, 9 Wu D.... Hu G.-F. (Ann. Neurol. 2007)
    3. Mutations of the ANG gene in French patients with sporadic amyotrophic lateral sclerosis. (PubMed id 18852347)1, 4, 9 Paubel A....Vourc'h P. (Arch. Neurol. 2008)
    4. Binding of phosphate and pyrophosphate ions at the active site of human angiogenin as revealed by X-ray crystallography. (PubMed id 11468363)1, 2, 9 Leonidas D.D....Acharya K.R. (Protein Sci. 2001)
    5. Identification of novel Angiogenin (ANG) gene missense variants in German patients with amyotrophic lateral sclerosis. (PubMed id 19363631)1, 4, 9 FernA!ndez-Santiago R....Ludolph A. (J. Neurol. 2009)
    6. Characterization of human angiogenin variants implicated in amyotrophic lateral sclerosis. (PubMed id 17900154)1, 2, 9 Crabtree B.... Acharya K.R. (Biochemistry 2007)
    7. Crystallographic studies on the role of the C-terminal segment of human angiogenin in defining enzymatic potency. (PubMed id 11851402)1, 2, 9 Leonidas D.D.... Acharya K.R. (Biochemistry 2002)
    8. Refined crystal structures of native human angiogenin and two active site variants: implications for the unique functional properties of an enzyme involved in neovascularisation during tumour growth. (PubMed id 9918722)1, 2, 9 Leonidas D.D....Acharya K.R. (J. Mol. Biol. 1999)
    9. [Genetic determinants of cardiovascular remodeling in Uzbek patients with essential hypertension]. (PubMed id 19253715)1, 4, 9 Eliseeva M.R....Abdullaeva G.Z.h. (Ter. Arkh. 2009)
    10. A novel angiogenin gene mutation in a sporadic patient with amyotrophic lateral sclerosis from southern Italy. (PubMed id 17703939)1, 2, 9 Conforti F.L.... Quattrone A. (Neuromuscul. Disord. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 283 HGNC: 483 AceView: ANG Ensembl:ENSG00000214274 euGenes: HUgn283
    ECgene: ANG H-InvDB: ANG

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for ANG Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ANG Genetics and Cytogenetics in Oncology and Haematology
    R&D Systems' cytokine mini-reviews: Angiogeninhttp://www.rndsystems.com/molecule_detail.aspx?m=1054
    Functional Glycomics Gateway - Glycan Bindinghttp://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_other_803
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=ANG[genesymbol]

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for ANG gene:
    Search GeneIP for patents involving ANG

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Small Molecules at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of ANG
     
     EMD Millipore genomic analysis products

      
     Antibodies for ANG (Angiogenin)   Browse Cell Culture Products  
     ELISAs for ANG (Angiogenin)   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Luminex Assays for ANG (Angiogenin)  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Recombinant/Natural Proteins for ANG (Angiogenin)   Browse Stem Cell Products  
     Browse cDNA Clones   Proteome Profiler Antibody Arrays for ANG (Angiogenin)  
     OriGene Antibodies for ANG   OriGene RNAi products in human, mouse, rat for ANG  
     OriGene qPCR primer pairs and template standards for ANG   OriGene Protein Over-expression Lysate for ANG  
     OriGene MassSpec for ANG   OriGene clones in human, mouse for ANG  
     OriGene qSTAR qPCR primer pairs in human, mouse for ANG   OriGene Purified Protein for ANG  
     OriGene ORF clones in mouse, rat for ANG   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ANG   OriGene Custom Protein Services for ANG  

     
     
     Block miRNA regulation of human, mouse, rat ANG using miScript Target Protectors SeqTarget long-range PCR primers for resequencing ANG
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ANG Predesigned siRNA for gene silencing in human, mouse, rat ANG
     QuantiFast Probe-based Assays in human, mouse, rat ANG QuantiTect SYBR Green Assays in human, mouse, rat ANG
     PCR Arrays including human, mouse, rat ANG Search Chromatin IP Primers for ANG
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ANG  GeneGlobe Interaction Network for ANG
     Regulatory tfbs in ANG promoter
     GenScript Custom Purified and Recombinant Proteins Services for ANG GenScript cDNA clones with any tag delivered in your preferred vector for ANG
     GenScript Custom Assay Services for ANG GenScript Custom overexpressing Cell Line Services for ANG
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for ANG (ANGI)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for ANG
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     ANG antibodies
     ANG proteins
     ANG lysates
     Antibodies for ANG
     See all of Abcam's Antibodies, Kits and Proteins for ANG
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for ANG
     Antibodies for ANG
     ELISAs for ANG
     CLIAs for ANG



     Browse ESI BIO Cell Lines and PureStem Progenitors for ANG
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANG
     SwitchGear 3'UTR luciferase reporter plasmids for ANG
     SwitchGear Promoter luciferase reporter plasmids for ANG
     ThermoFisher Antibodies for ANG
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ANG
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ANG
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ANG
     LSBio Antibodies in human, mouse, rat for ANG
     Browse compounds at ApexBio
     Search Addgene for plasmids for ANG
      Search eBioscience for proteins for ANG
      Search eBioscience for elisas for ANG
      eBioscience FlowRNA Probe Sets
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     antibodies-online antibodies for ANG (53 products)
     antibodies-online kits for ANG (55 products)
     antibodies-online peptides for ANG
     antibodies-online proteins for ANG (35 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      ANG gene at Home site.
    Version: 3.12.234 23 Oct 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4