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Aliases & Descriptions for ANAPC7
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Descriptions Cyclosome subunit 7 2 , 3 anaphase promoting complex subunit 7 2 anaphase-promoting complex subunit 7 2
Search outside databases for aliases for ANAPC7 genePrevious GC identifers: GC12M9C0183 GC12P9H0002 GC12U900269 GC12M109274
Summaries for ANAPC7 (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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EntrezGene summary for ANAPC7 : This gene encodes a tetratricopeptide repeat containing component of the anaphase promotingcomplex/cyclosome (APC/C), a large E3 ubiquitin ligase that controls cell cycle progression bytargeting a number of cell cycle regulators such as B-type cyclins for 26S proteasome-mediateddegradation through ubiquitination. The encoded protein is required for proper proteinubiquitination function of APC/C and for the interaction of APC/C with certain transcriptioncoactivators. Multiple transcript variants encoding different isoforms have been found for thisgene. [provided by RefSeq] UniProtKB/Swiss-Prot: APC7_HUMAN, Q9UJX3 Function : Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulatedubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle
Gene Wiki entry for ANAPC7
Genomic Location for ANAPC7
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
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Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the ANAPC7 gene Entrez Gene cytogenetic band: 12q24.11 Ensembl cytogenetic band: 12q24.11 HGNC cytogenetic band: 12q13.12 ANAPC7 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 12 GeneLoc Exon Structure
GeneLoc location for GC12M109295:
(about GC identifiers )
Start:
109,295,667 bp from pter
End:
109,325,868 bp from pter
Size:
30,202 bases
Orientation:
minus strand
RefSeq DNA sequence: NC_000012.10 NT_009775.16 Proteins for ANAPC7
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: APC7_HUMAN, Q9UJX3 (See
protein sequence )Recommended Name: Anaphase-promoting complex subunit 7 Size : 565 amino acids; 63133 Da
Subunit : The APC/C is composed of at least 11 subunits
Sequence caution : Sequence=AAH17316.2; Type=Erroneous translation; Note=Wrong choice of frame;
PDB structures from and Proteopedia : 3FFL (3D)
 
Secondary accessions : Q96AC4 Q96GF4 Q9BU24 Q9NT16
Post-translational modifications:
View phosphorylation sites using PhosphoSite 2
REFSEQ proteins (2 alternative transcripts):
NP_001131136.1 NP_057322.2 ENSEMBL proteins: ENSP00000346363 Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 2 Gene Ontology (GO) cellular component terms (links to tree view) :
About this table Antibodies for ANAPC7: Assays for ANAPC7:
Protein
Domains/ Families for ANAPC7(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry Q9UJX3 ProtoNet protein and cluster: Q9UJX3
UniProtKB/Swiss-Prot: APC7_HUMAN, Q9UJX3 Similarity : Belongs to the APC7 familySimilarity : Contains 7 TPR repeats
Gene Function for ANAPC7
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
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Clones , and
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siRNAs from
Applied Biosystems ,
SYBR primers from OriGene ,
Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_016238 Applied Biosystems Silencer ® siRNAs for ANAPC7 Sigma-Aldrich siRNA and siRNA Panels for ANAPC7 Sigma-Aldrich shRNA for ANAPC7 Explore Sigma-Aldrich super-pooled esiRNAs                OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_001137664                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_001137664                                  untagged cDNA clones in CMV expression vector (see all 2 ): NM_001137664  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_016238 UniProtKB/Swiss-Prot: APC7_HUMAN, Q9UJX3 Function : Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulatedubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle
1 Gene Ontology (GO) molecular function term (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0005488 binding
IEA --
About this table
Pathways & Interactions for ANAPC7
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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1 Sigma-Aldrich "Your Favorite Gene" Pathway for ANAPC7 (Your Favorite Gene powered by Ingenuity) UniProtKB/Swiss-Prot: APC7_HUMAN, Q9UJX3 Pathway : Protein modification; protein ubiquitination
Gene Network CentralTM Interacting Genes and Proteins Network for ANAPC7 5/77 Interacting proteins for ANAPC7 (ENSP00000346363 3 ) via UniProtKB, MINT, and/or STRING (see all 77
)About this table 5/7 Gene Ontology (GO) biological process terms (links to tree view) (see all 7
):
GO ID Qualified GO term Evidence PubMed IDs GO:0007049 cell cycle
IEA -- GO:0007067 mitosis
IEA -- GO:0019941 modification-dependent protein catabolic process
IEA -- GO:0031145 anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
EXP 11285280 GO:0051301 cell division
IEA --
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Drugs & Compounds for ANAPC7 (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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Browse Tocris compounds for ANAPC7
Transcripts for ANAPC7(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_016238 Sigma-Aldrich siRNA and siRNA Panels for ANAPC7 Sigma-Aldrich shRNA for ANAPC7 Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_001137664 NM_016238
REFSEQ mRNAs for ANAPC7 gene (2 alternative transcripts): NM_001137664.1 NM_016238.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_001137664 NM_016238
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_001137664                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_001137664                                  untagged cDNA clones in CMV expression vector (see all 2 ): NM_001137664  
Additional cDNA sequence: AF004561.1 AF006086.1 AF191340.1 AK021809.1 AK297309.1 AK311789.1 AL137586.1 AL157481.1 AL357196.1 AY007104.1 BC002941.2 BC009498.2 BC017316.2 BC040130.1 BC067747.1 BC078162.1 BC098264.1 BC098295.1 BC098362.1 BC099732.1 BC111798.1 BC141848.1 BC148236.2 CR407667.1 CR595174.1 CR606213.1 CR611961.1 CR616701.1 DQ328220.1
24/47 DOTS entries (see all 47
): DT.95290197 DT.100666390 DT.95162379 DT.97862620 DT.100666385 DT.444484 DT.99950552 DT.100782748 DT.102845358 DT.95162376 DT.312557 DT.121216052 DT.100666386 DT.121216159 DT.120690346 DT.121216120 DT.92453362 DT.121216080 DT.121216306 DT.100666384 DT.92453363 DT.40108271 DT.75112546 DT.86859893
24/983 AceView cDNA sequences (see all 983
):BU195572 AI298479 CB069455 BU153627 AL137586 AW161094 BQ003692 AI373621 BM792288 AA159032 CA309839 BE910721 CR595174 CB159862 BI715388 BQ922005 AI621325 BG387564 AA629219 BM841738 BM550338 BM451842 BG825894 BG825422
highest scoring ESTs for ANAPC7 :AA131793 AA334730 AF191340 AI358798 AI690444 AI910731 AK021809 AU143374 AW135464 AW471105
Unigene Cluster for ANAPC7: Anaphase promoting complex subunit 7 Hs.524741 [show with all ESTs ] Unigene Representative Sequence: NM_016238 GeneLoc Exon Structure 5/11 Alternative Splicing Database (ASD) splice patterns (SP) for ANAPC7 (see all 11
) ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b ^ 12a · 12b ^ SP1 :         -   -                 -       -           -   -       -   SP2 :         -   -                 -       -           -   -         SP3 :                           -                           SP4 :         -   -   -   -             -                           SP5 :         -   -         -                                  
ExUns: 13a · 13b · 13c SP1 :       SP2 :       SP3 :       SP4 :       SP5 :      
About this scheme ECgene alternative splicing isoforms for ANAPC7 1 Ensembl transcript including schematic representation : ENST00000354390
Expression for ANAPC7
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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ANAPC7 expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for ANAPC7 1 / 2 / 3
7 probe-sets matching ANAPC7 gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: --SOURCE GeneReport for Unigene cluster: Hs.524741
Orthologs for ANAPC7
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
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Gene Trees according to Ensembl )
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Orthologs for ANAPC7 gene from 5/11 species (see all 11
)
About this table Species with no ortholog for ANAPC7 ENSEMBL Gene Tree for ANAPC7 Paralogs for ANAPC7 (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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--
SNPs/Variants for ANAPC7 (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for ANAPC7 (up to first 250kb)
Disorders & Mutations for ANAPC7
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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OMIM: 606949
Medical News for ANAPC7 (Possibly Related Articles in
Doctor's Guide )
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--
Publications for ANAPC7 (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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10/30 PubMed articles for ANAPC7 gene (see all 30
):
Search for ANAPC7
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing ANAPC7
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
and/or
H-InvDB )
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Other Databases showing ANAPC7
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Specialized Databases showing ANAPC7 (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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