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Aliases for ANAPC7 Gene

Aliases for ANAPC7 Gene

  • Anaphase Promoting Complex Subunit 7 2 3 5
  • Cyclosome Subunit 7 3 4
  • APC7 3 4
  • Anaphase-Promoting Complex Subunit 7 3

External Ids for ANAPC7 Gene

Previous GeneCards Identifiers for ANAPC7 Gene

  • GC12M9C0183
  • GC12P9H0002
  • GC12U900269
  • GC12M109274
  • GC12M109295
  • GC12M110810
  • GC12M107829

Summaries for ANAPC7 Gene

Entrez Gene Summary for ANAPC7 Gene

  • This gene encodes a tetratricopeptide repeat containing component of the anaphase promoting complex/cyclosome (APC/C), a large E3 ubiquitin ligase that controls cell cycle progression by targeting a number of cell cycle regulators such as B-type cyclins for 26S proteasome-mediated degradation through ubiquitination. The encoded protein is required for proper protein ubiquitination function of APC/C and for the interaction of APC/C with certain transcription coactivators. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2008]

GeneCards Summary for ANAPC7 Gene

ANAPC7 (Anaphase Promoting Complex Subunit 7) is a Protein Coding gene. Among its related pathways are CDK-mediated phosphorylation and removal of Cdc6 and Cell Cycle, Mitotic. GO annotations related to this gene include protein phosphatase binding.

UniProtKB/Swiss-Prot for ANAPC7 Gene

  • Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of Lys-11-linked polyubiquitin chains and, to a lower extent, the formation of Lys-48- and Lys-63-linked polyubiquitin chains.

Gene Wiki entry for ANAPC7 Gene

Additional gene information for ANAPC7 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANAPC7 Gene

Genomics for ANAPC7 Gene

Regulatory Elements for ANAPC7 Gene

Enhancers for ANAPC7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12H109993 1.3 ENCODE dbSUPER 20 +408.3 408290 3 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ZNF207 SP3 ZHX2 IFT81 UBE3B ALKBH2 ANAPC7 RNU4-32P GIT2 GLTP ENSG00000277299
GH12H110499 1.2 ENCODE 19.9 -97.3 -97309 3 MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC MEF2D ZNF610 IFT81 ARPC3 FAM216A ANAPC7 ENSG00000257268 GPN3 ANKRD13A TCHP ENSG00000278993 GC12M110497
GH12H110279 1.4 ENCODE dbSUPER 11.6 +120.9 120910 5 HDGF PKNOX1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 GPN3 ARPC3 ANAPC7 IFT81 ATP2A2 GC12M110365 RN7SL769P
GH12H109571 1.2 ENCODE 11.5 +830.6 830557 3 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 KCTD10 ANAPC7 RNU4-32P GPN3 MYO1H UBE3B MVK GC12M109566
GH12H111367 1.1 ENCODE 11.5 -964.8 -964787 2 PKNOX1 FOXA2 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 YY1 ZNF143 ADAM1A PCNPP1 ANAPC7 ATXN2 FAM109A TMEM116 RNA5SP373
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ANAPC7 on UCSC Golden Path with GeneCards custom track

Promoters for ANAPC7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000057321 330 2001 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF207 SP3

Genomic Location for ANAPC7 Gene

Chromosome:
12
Start:
110,372,900 bp from pter
End:
110,403,730 bp from pter
Size:
30,831 bases
Orientation:
Minus strand

Genomic View for ANAPC7 Gene

Genes around ANAPC7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANAPC7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANAPC7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANAPC7 Gene

Proteins for ANAPC7 Gene

  • Protein details for ANAPC7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UJX3-APC7_HUMAN
    Recommended name:
    Anaphase-promoting complex subunit 7
    Protein Accession:
    Q9UJX3
    Secondary Accessions:
    • Q96AC4
    • Q96GF4
    • Q9BU24
    • Q9NT16

    Protein attributes for ANAPC7 Gene

    Size:
    599 amino acids
    Molecular mass:
    66855 Da
    Quaternary structure:
    • V-shaped homodimer. The mammalian APC/C is composed of 14 distinct subunits that assemble into a complex of at least 19 chains with a combined molecular mass of around 1.2 MDa.
    SequenceCaution:
    • Sequence=AAH17316.2; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ANAPC7 Gene

    Alternative splice isoforms for ANAPC7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ANAPC7 Gene

Post-translational modifications for ANAPC7 Gene

  • Ubiquitination at posLast=9999, posLast=115115, posLast=139139, posLast=193193, Lys293, Lys306, Lys353, posLast=364364, posLast=467467, posLast=477477, Lys482, and posLast=491491
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ANAPC7 Gene

Domains & Families for ANAPC7 Gene

Gene Families for ANAPC7 Gene

Protein Domains for ANAPC7 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UJX3

UniProtKB/Swiss-Prot:

APC7_HUMAN :
  • Belongs to the APC7 family.
Family:
  • Belongs to the APC7 family.
genes like me logo Genes that share domains with ANAPC7: view

Function for ANAPC7 Gene

Molecular function for ANAPC7 Gene

UniProtKB/Swiss-Prot Function:
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of Lys-11-linked polyubiquitin chains and, to a lower extent, the formation of Lys-48- and Lys-63-linked polyubiquitin chains.

Phenotypes From GWAS Catalog for ANAPC7 Gene

Gene Ontology (GO) - Molecular Function for ANAPC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20360068
GO:0019903 protein phosphatase binding IPI 21241890
genes like me logo Genes that share ontologies with ANAPC7: view
genes like me logo Genes that share phenotypes with ANAPC7: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ANAPC7
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ANAPC7 Gene

Localization for ANAPC7 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ANAPC7 gene
Compartment Confidence
nucleus 5
cytosol 5
cytoskeleton 2
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ANAPC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21241890
GO:0005654 nucleoplasm TAS --
GO:0005680 anaphase-promoting complex IDA 16364912
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with ANAPC7: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ANAPC7 Gene

Pathways & Interactions for ANAPC7 Gene

SuperPathways for ANAPC7 Gene

SuperPathway Contained pathways
1 CDK-mediated phosphorylation and removal of Cdc6
2 APC-Cdc20 mediated degradation of Nek2A
3 Class I MHC mediated antigen processing and presentation
4 Cell Cycle, Mitotic
.60
5 Cellular Senescence (REACTOME)
genes like me logo Genes that share pathways with ANAPC7: view

UniProtKB/Swiss-Prot Q9UJX3-APC7_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

SIGNOR curated interactions for ANAPC7 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for ANAPC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007049 cell cycle IEA --
GO:0016567 protein ubiquitination IEA --
GO:0031145 anaphase-promoting complex-dependent catabolic process TAS --
GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process TAS --
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process TAS --
genes like me logo Genes that share ontologies with ANAPC7: view

Drugs & Compounds for ANAPC7 Gene

(1) Drugs for ANAPC7 Gene - From: ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
TAME Pharma 0

(1) ApexBio Compounds for ANAPC7 Gene

Compound Action Cas Number
TAME 901-47-3
genes like me logo Genes that share compounds with ANAPC7: view

Drug Products

Transcripts for ANAPC7 Gene

Unigene Clusters for ANAPC7 Gene

Anaphase promoting complex subunit 7:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ANAPC7
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for ANAPC7 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b ^ 12a · 12b ^
SP1: - - - - - - -
SP2: - - - - - -
SP3: -
SP4: - - - - -
SP5: - - -
SP6: - -
SP7: - - -
SP8: - -
SP9: -
SP10:
SP11: - - -

ExUns: 13a · 13b · 13c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for ANAPC7 Gene

GeneLoc Exon Structure for
ANAPC7
ECgene alternative splicing isoforms for
ANAPC7

Expression for ANAPC7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ANAPC7 Gene

Protein differential expression in normal tissues from HIPED for ANAPC7 Gene

This gene is overexpressed in Breast (23.5), Bone (22.4), and Lung (12.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ANAPC7 Gene



Protein tissue co-expression partners for ANAPC7 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ANAPC7 Gene:

ANAPC7

SOURCE GeneReport for Unigene cluster for ANAPC7 Gene:

Hs.719935

Evidence on tissue expression from TISSUES for ANAPC7 Gene

  • Skin(4.3)
  • Nervous system(3.2)
  • Pancreas(2)
genes like me logo Genes that share expression patterns with ANAPC7: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ANAPC7 Gene

Orthologs for ANAPC7 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ANAPC7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ANAPC7 33 34
  • 99.78 (n)
oppossum
(Monodelphis domestica)
Mammalia ANAPC7 34
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ANAPC7 34
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ANAPC7 33 34
  • 95.48 (n)
cow
(Bos Taurus)
Mammalia ANAPC7 33 34
  • 94.65 (n)
mouse
(Mus musculus)
Mammalia Anapc7 33 16 34
  • 88.79 (n)
rat
(Rattus norvegicus)
Mammalia Anapc7 33
  • 88.5 (n)
chicken
(Gallus gallus)
Aves ANAPC7 33 34
  • 82.06 (n)
lizard
(Anolis carolinensis)
Reptilia ANAPC7 34
  • 93 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia anapc7 33
  • 78.88 (n)
zebrafish
(Danio rerio)
Actinopterygii anapc7 33 34
  • 75.58 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003902 33
  • 45.4 (n)
fruit fly
(Drosophila melanogaster)
Insecta Apc7 33 34
  • 40.64 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G39090 33
  • 44.67 (n)
rice
(Oryza sativa)
Liliopsida Os05g0149900 33
  • 41.51 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 37 (a)
OneToOne
Species where no ortholog for ANAPC7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ANAPC7 Gene

ENSEMBL:
Gene Tree for ANAPC7 (if available)
TreeFam:
Gene Tree for ANAPC7 (if available)

Paralogs for ANAPC7 Gene

(1) SIMAP similar genes for ANAPC7 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with ANAPC7: view

No data available for Paralogs for ANAPC7 Gene

Variants for ANAPC7 Gene

Sequence variations from dbSNP and Humsavar for ANAPC7 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000057896 -- 110,396,289(+) TGCAG(A/T)ATTTC nc-transcript-variant, reference, missense, utr-variant-5-prime
rs1000121777 -- 110,402,661(+) AGGGA(C/T)ATGCA intron-variant, upstream-variant-2KB
rs1000395635 -- 110,389,998(+) AGAAT(A/G)TAGAA intron-variant
rs1000425789 -- 110,379,742(+) AAATC(-/ACTCCTAG)ACTCC intron-variant
rs1000458883 -- 110,373,324(+) GGGTT(C/T)CTGAG downstream-variant-500B, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ANAPC7 Gene

Variant ID Type Subtype PubMed ID
esv1001296 CNV deletion 20482838
nsv1044428 CNV gain 25217958
nsv1115970 CNV insertion 24896259

Variation tolerance for ANAPC7 Gene

Residual Variation Intolerance Score: 15% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.76; 47.04% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ANAPC7 Gene

Human Gene Mutation Database (HGMD)
ANAPC7
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ANAPC7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANAPC7 Gene

Disorders for ANAPC7 Gene

Relevant External Links for ANAPC7

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ANAPC7

No disorders were found for ANAPC7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANAPC7 Gene

Publications for ANAPC7 Gene

  1. Identification of a cullin homology region in a subunit of the anaphase-promoting complex. (PMID: 9469815) Yu H … Kirschner MW (Science (New York, N.Y.) 1998) 3 4 22 60
  2. Molecular architecture and mechanism of the anaphase-promoting complex. (PMID: 25043029) Chang LF … Barford D (Nature 2014) 3 4 60
  3. Crystal structure of the N-terminal domain of anaphase-promoting complex subunit 7. (PMID: 19091741) Han D … Kim Y (The Journal of biological chemistry 2009) 3 4 60
  4. Mechanism of ubiquitin-chain formation by the human anaphase-promoting complex. (PMID: 18485873) Jin L … Rape M (Cell 2008) 3 4 60
  5. Localization of the coactivator Cdh1 and the cullin subunit Apc2 in a cryo-electron microscopy model of vertebrate APC/C. (PMID: 16364912) Dube P … Stark H (Molecular cell 2005) 3 4 60

Products for ANAPC7 Gene

Sources for ANAPC7 Gene

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