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Aliases for ANAPC7 Gene

Aliases for ANAPC7 Gene

  • Anaphase Promoting Complex Subunit 7 2 3 5
  • Cyclosome Subunit 7 3 4
  • APC7 3 4

External Ids for ANAPC7 Gene

Previous GeneCards Identifiers for ANAPC7 Gene

  • GC12M9C0183
  • GC12P9H0002
  • GC12U900269
  • GC12M109274
  • GC12M109295
  • GC12M110810
  • GC12M107829

Summaries for ANAPC7 Gene

Entrez Gene Summary for ANAPC7 Gene

  • This gene encodes a tetratricopeptide repeat containing component of the anaphase promoting complex/cyclosome (APC/C), a large E3 ubiquitin ligase that controls cell cycle progression by targeting a number of cell cycle regulators such as B-type cyclins for 26S proteasome-mediated degradation through ubiquitination. The encoded protein is required for proper protein ubiquitination function of APC/C and for the interaction of APC/C with certain transcription coactivators. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2008]

GeneCards Summary for ANAPC7 Gene

ANAPC7 (Anaphase Promoting Complex Subunit 7) is a Protein Coding gene. Among its related pathways are Immune System and Cellular Senescence. GO annotations related to this gene include protein phosphatase binding.

UniProtKB/Swiss-Prot for ANAPC7 Gene

  • Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of Lys-11-linked polyubiquitin chains and, to a lower extent, the formation of Lys-48- and Lys-63-linked polyubiquitin chains.

Gene Wiki entry for ANAPC7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANAPC7 Gene

Genomics for ANAPC7 Gene

Regulatory Elements for ANAPC7 Gene

Promoters for ANAPC7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ANAPC7 on UCSC Golden Path with GeneCards custom track

Genomic Location for ANAPC7 Gene

Chromosome:
12
Start:
110,372,900 bp from pter
End:
110,403,730 bp from pter
Size:
30,831 bases
Orientation:
Minus strand

Genomic View for ANAPC7 Gene

Genes around ANAPC7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANAPC7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANAPC7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANAPC7 Gene

Proteins for ANAPC7 Gene

  • Protein details for ANAPC7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UJX3-APC7_HUMAN
    Recommended name:
    Anaphase-promoting complex subunit 7
    Protein Accession:
    Q9UJX3
    Secondary Accessions:
    • Q96AC4
    • Q96GF4
    • Q9BU24
    • Q9NT16

    Protein attributes for ANAPC7 Gene

    Size:
    599 amino acids
    Molecular mass:
    66855 Da
    Quaternary structure:
    • V-shaped homodimer. The mammalian APC/C is composed of 14 distinct subunits that assemble into a complex of at least 19 chains with a combined molecular mass of around 1.2 MDa.
    SequenceCaution:
    • Sequence=AAH17316.2; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ANAPC7 Gene

    Alternative splice isoforms for ANAPC7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ANAPC7 Gene

Proteomics data for ANAPC7 Gene at MOPED

Post-translational modifications for ANAPC7 Gene

  • Ubiquitination at Lys 99, Lys 115, Lys 139, Lys 193, Lys 293, Lys 306, Lys 353, Lys 364, Lys 467, Lys 477, Lys 482, and Lys 491
  • Modification sites at PhosphoSitePlus

Other Protein References for ANAPC7 Gene

Antibody Products

No data available for DME Specific Peptides for ANAPC7 Gene

Domains & Families for ANAPC7 Gene

Protein Domains for ANAPC7 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UJX3

UniProtKB/Swiss-Prot:

APC7_HUMAN :
  • Belongs to the APC7 family.
  • Contains 10 TPR repeats.
Family:
  • Belongs to the APC7 family.
Similarity:
  • Contains 10 TPR repeats.
genes like me logo Genes that share domains with ANAPC7: view

Function for ANAPC7 Gene

Molecular function for ANAPC7 Gene

UniProtKB/Swiss-Prot Function:
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of Lys-11-linked polyubiquitin chains and, to a lower extent, the formation of Lys-48- and Lys-63-linked polyubiquitin chains.
genes like me logo Genes that share phenotypes with ANAPC7: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ANAPC7 Gene

Localization for ANAPC7 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ANAPC7 Gene COMPARTMENTS Subcellular localization image for ANAPC7 gene
Compartment Confidence
cytosol 5
nucleus 5
cytoskeleton 2
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ANAPC7 Gene

Pathways & Interactions for ANAPC7 Gene

SuperPathways for ANAPC7 Gene

Superpath Contained pathways
1 CDK-mediated phosphorylation and removal of Cdc6
2 APC-Cdc20 mediated degradation of Nek2A
3 Cellular Senescence
4 Cell Cycle, Mitotic
.61
5 Mitotic Metaphase and Anaphase
genes like me logo Genes that share pathways with ANAPC7: view

UniProtKB/Swiss-Prot Q9UJX3-APC7_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

SIGNOR curated interactions for ANAPC7 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for ANAPC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007067 mitotic nuclear division IEA --
GO:0031145 anaphase-promoting complex-dependent catabolic process TAS --
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process TAS --
GO:0051301 cell division IEA --
GO:0051436 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle TAS --
genes like me logo Genes that share ontologies with ANAPC7: view

Drugs & Compounds for ANAPC7 Gene

(1) Drugs for ANAPC7 Gene - From: ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
TAME Pharma 0

(1) ApexBio Compounds for ANAPC7 Gene

Compound Action Cas Number
TAME 901-47-3
genes like me logo Genes that share compounds with ANAPC7: view

Transcripts for ANAPC7 Gene

Unigene Clusters for ANAPC7 Gene

Anaphase promoting complex subunit 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ANAPC7 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b ^ 12a · 12b ^
SP1: - - - - - - -
SP2: - - - - - -
SP3: -
SP4: - - - - -
SP5: - - -
SP6: - -
SP7: - - -
SP8: - -
SP9: -
SP10:
SP11: - - -

ExUns: 13a · 13b · 13c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for ANAPC7 Gene

GeneLoc Exon Structure for
ANAPC7
ECgene alternative splicing isoforms for
ANAPC7

Expression for ANAPC7 Gene

mRNA expression in normal human tissues for ANAPC7 Gene

Protein differential expression in normal tissues from HIPED for ANAPC7 Gene

This gene is overexpressed in Breast (23.5), Bone (22.4), and Lung (12.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ANAPC7 Gene



SOURCE GeneReport for Unigene cluster for ANAPC7 Gene Hs.719935

genes like me logo Genes that share expression patterns with ANAPC7: view

Protein tissue co-expression partners for ANAPC7 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ANAPC7 Gene

Orthologs for ANAPC7 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ANAPC7 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ANAPC7 35
  • 94.65 (n)
  • 97.32 (a)
ANAPC7 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ANAPC7 35
  • 95.48 (n)
  • 97.49 (a)
ANAPC7 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Anapc7 35
  • 88.79 (n)
  • 98.23 (a)
Anapc7 16
Anapc7 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ANAPC7 35
  • 99.78 (n)
  • 99.67 (a)
ANAPC7 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Anapc7 35
  • 88.5 (n)
  • 98.41 (a)
oppossum
(Monodelphis domestica)
Mammalia ANAPC7 36
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ANAPC7 36
  • 97 (a)
OneToOne
chicken
(Gallus gallus)
Aves ANAPC7 35
  • 82.06 (n)
  • 96.81 (a)
ANAPC7 36
  • 95 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ANAPC7 36
  • 93 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia anapc7 35
  • 78.88 (n)
  • 94.34 (a)
zebrafish
(Danio rerio)
Actinopterygii anapc7 35
  • 75.58 (n)
  • 89.38 (a)
anapc7 36
  • 89 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003902 35
  • 45.4 (n)
  • 34.4 (a)
fruit fly
(Drosophila melanogaster)
Insecta Apc7 35
  • 40.64 (n)
  • 27.01 (a)
Apc7 36
  • 24 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G39090 35
  • 44.67 (n)
  • 30.8 (a)
rice
(Oryza sativa)
Liliopsida Os05g0149900 35
  • 41.51 (n)
  • 27.16 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 37 (a)
OneToOne
Species with no ortholog for ANAPC7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ANAPC7 Gene

ENSEMBL:
Gene Tree for ANAPC7 (if available)
TreeFam:
Gene Tree for ANAPC7 (if available)

Paralogs for ANAPC7 Gene

(1) SIMAP similar genes for ANAPC7 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with ANAPC7: view

No data available for Paralogs for ANAPC7 Gene

Variants for ANAPC7 Gene

Sequence variations from dbSNP and Humsavar for ANAPC7 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs4131850 -- 110,374,748(-) TGGGA(C/T)ACCTA intron-variant
rs4131851 -- 110,374,540(-) ACTCT(A/G)AAAAT intron-variant
rs4131852 -- 110,374,852(-) TCCTG(C/G)GGTCT intron-variant
rs6606746 -- 110,378,889(-) agagc(A/G)agact intron-variant
rs11554605 -- 110,375,877(+) ATGTT(A/G)TTAAT intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ANAPC7 Gene

Variant ID Type Subtype PubMed ID
esv1001296 CNV Deletion 20482838

Variation tolerance for ANAPC7 Gene

Residual Variation Intolerance Score: 15% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.76; 47.04% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ANAPC7 Gene

HapMap Linkage Disequilibrium report
ANAPC7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANAPC7 Gene

Disorders for ANAPC7 Gene

Relevant External Links for ANAPC7

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ANAPC7

No disorders were found for ANAPC7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANAPC7 Gene

Publications for ANAPC7 Gene

  1. Identification of a cullin homology region in a subunit of the anaphase-promoting complex. (PMID: 9469815) Yu H. … Kirschner M.W. (Science 1998) 3 4 23 67
  2. Deregulation of Rb-E2F1 axis causes chromosomal instability by engaging the transactivation function of Cdc20-anaphase-promoting complex/cyclosome. (PMID: 25368385) Nath S. … Roychoudhury S. (Mol. Cell. Biol. 2015) 3
  3. Structure of an APC3-APC16 complex: insights into assembly of the anaphase-promoting complex/cyclosome. (PMID: 25490258) Yamaguchi M. … Schulman B.A. (J. Mol. Biol. 2015) 3
  4. Atomic structure of the APC/C and its mechanism of protein ubiquitination. (PMID: 26083744) Chang L. … Barford D. (Nature 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for ANAPC7 Gene

Sources for ANAPC7 Gene

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