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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ANAPC7 Gene

protein-coding GIFtS: 55
GCID: GC12M110810

anaphase promoting complex subunit 7

Explore 2 diseases affiliated with
ANAPC7 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Anaphase Promoting Complex Subunit 7¹ ²
APC7¹ ² ³
Cyclosome Subunit 7² ³
Anaphase-Promoting Complex Subunit 7²

External Ids:	HGNC: 17380¹	Entrez Gene: 51434²	Ensembl: ENSG00000196510⁷	OMIM: 606949⁵	UniProtKB: Q9UJX3³

Export aliases for ANAPC7 gene to outside databases

Previous GC identifers: GC12M9C0183 GC12P9H0002 GC12U900269 GC12M109274 GC12M109295 GC12M107829

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ANAPC7:

This gene encodes a tetratricopeptide repeat containing component of the anaphase promoting complex/cyclosome (APC/C),

a large E3 ubiquitin ligase that controls cell cycle progression by targeting a number of cell cycle regulators such

as B-type cyclins for 26S proteasome-mediated degradation through ubiquitination. The encoded protein is required for

proper protein ubiquitination function of APC/C and for the interaction of APC/C with certain transcription

coactivators. Multiple transcript variants encoding different isoforms have been found for this gene. (provided by

RefSeq, Nov 2008)

UniProtKB/Swiss-Prot: APC7_HUMAN, Q9UJX3

Function: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase

that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating

ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked

polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains

Gene Wiki entry for ANAPC7

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000012.11 NC_018923.1 NT_009775.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ANAPC7 gene promoter:
Bach1 SREBP-1c STAT1beta Lmo2 GATA-1 SREBP-1b RORalpha1 SREBP-1a GATA-6 LyF-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ANAPC7 promoter sequence

Search SABiosciences Chromatin IP Primers for ANAPC7

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ANAPC7

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.11 Ensembl cytogenetic band: 12q24.11 HGNC cytogenetic band: 12q13.12

ANAPC7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ANAPC7 gene location

GeneLoc information about chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12M110810: view genomic region (about GC identifiers)

Start:	110,810,705 bp from pter	End:	110,841,535 bp from pter
Size:	30,831 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: APC7_HUMAN, Q9UJX3 (See protein sequence)

Recommended Name: Anaphase-promoting complex subunit 7

Size: 599 amino acids; 66855 Da

Subunit: Homodimer. The APC/C is composed of at least 12 subunits

Caution: It is uncertain whether Met-1 or Met-35 is the initiator

Sequence caution: Sequence=AAH17316.2; Type=Erroneous translation; Note=Wrong choice of frame;

1 PDB 3D structure from and Proteopedia for ANAPC7:

3FFL (3D)

Secondary accessions: Q96AC4 Q96GF4 Q9BU24 Q9NT16

Alternative splicing: 2 isoforms: Q9UJX3-1 Q9UJX3-2

Explore the universe of human proteins at neXtProt for ANAPC7: NX_Q9UJX3

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9UJX3

ANAPC7 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001131136.1 NP_057322.2

ENSEMBL proteins:

ENSP00000394394 ENSP00000449231 ENSP00000450293 ENSP00000449249 ENSP00000402314

ENSP00000447395 ENSP00000450219 ENSP00000450405

Reactome Protein details: Q9UJX3
Human Recombinant Protein Products:

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	Uscn Proteins for ANAPC7

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	--
GO:0005654	nucleoplasm	TAS	--
GO:0005680	anaphase-promoting complex	IDA	--
GO:0005829	cytosol	TAS	--

ANAPC7 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for ANAPC7

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ANAPC7 for domains About GeneDecksing

4 InterPro domains/families:

IPR011990 TPR-like_helical

IPR013105 TPR_2

IPR013026 TPR-contain_dom

IPR019734 TPR_repeat

Graphical View of Domain Structure for InterPro Entry Q9UJX3

ProtoNet protein and cluster: Q9UJX3

UniProtKB/Swiss-Prot: APC7_HUMAN, Q9UJX3

Similarity: Belongs to the APC7 family

Similarity: Contains 7 TPR repeats

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: APC7_HUMAN, Q9UJX3

Function: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase

that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating

ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked

polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains

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In Situ Assay
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Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0019903	protein phosphatase binding	IPI	--

ANAPC7 for ontologies About GeneDecksing

3 GenomeRNAi human phenotypes for ANAPC7:

Downregulation of NF-kappaB pa

Increased cell death HMECs cel

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/22 super-pathways (see all 22) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Ubiquitinated Orc1 is degraded by the proteasome

8/15 pathways (see all 15)
APC/C:Cdh1-mediated degradation of Skp2	0.74	APC/C:Cdc20 mediated degradation of mitotic proteins	0.69
APC/C:Cdc20 mediated degradation of Securin	0.74	APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	0.69
Degradation of multiubiquitinated Securin	0.74	Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	0.68
Autodegradation of Cdh1 by Cdh1:APC/C	0.70	Regulation of APC/C activators between G1/S and early anaphase	0.62

APC-Cdc20 mediated degradation of Nek2A

8/10 pathways (see all 10)
Degradation of multiubiquitinated Nek2A	1.00	Degradation of multiubiquitinated Cyclin B	0.76
APC-Cdc20 mediated degradation of Nek2A	1.00	Mitotic Spindle Checkpoint	0.75
Inactivation of APC/C via direct inhibition of the APC/C complex	0.78	Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	0.60
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	0.78	Phosphorylation of the APC/C	0.54

M Phase

M Phase	1.00	Mitotic Anaphase	0.85
Mitotic M-M/G1 phases	0.88	Separation of Sister Chromatids	0.80
Mitotic Metaphase and Anaphase	0.85

Antigen processing: Ubiquitination & Proteasome degradation

	Antigen processing: Ubiquitination & Proteasome degradation	1.00			Polyubiquitination of substrate	0.75
	Class I MHC mediated antigen processing & presentation	0.83			Ubiquitin mediated proteolysis	0.36

Cell cycle_Spindle assembly and chromosome separation

Cell cycle_Spindle assembly and chromosome separation

1.00

Cell cycle Spindle assembly and chromosome separation

0.94

Pathway sources
See GeneCards unified pathways
Show all pathways

5/9 EMD Millipore Pathways for ANAPC7 (see all 9)

	Cell cycle Role of APC in cell cycle regulation
	Meiosis
	Cell cycle Regulation of G1/S transition (part 1)
	Development TGF-beta receptor signaling
	Signal transduction PKA signaling

5/6 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for ANAPC7 (see all 6)

	Activation of PKA through GPCR
	Remodeling of Adherens Junctions
	cAMP Pathway
	CDC42 Pathway
	Mitotic Roles of Polo Like Kinases

5/7 GeneGo (Thomson Reuters) Pathways for ANAPC7 (see all 7)

	Cell cycle Role of APC in cell cycle regulation
	G-protein signaling G-Protein alpha-s signaling cascades
	Signal transduction PKA signaling
	Cell cycle Regulation of G1/S transition (part 1)
	Cell cycle Spindle assembly and chromosome separation

1 BioSystems Pathway for ANAPC7

TGF-beta Receptor Signaling Pathway

5/36 Reactome Pathways for ANAPC7 (see all 36)

	APC/C:Cdc20 mediated degradation of mitotic proteins
	Phosphorylation of the APC/C
	APC/C:Cdc20 mediated degradation of Securin
	Cdc20:Phospho-APC/C mediated degradation of Cyclin A
	Antigen processing: Ubiquitination & Proteasome degradation

4 Kegg Pathways (Kegg details for ANAPC7):

	Cell cycle
	Oocyte meiosis
	Ubiquitin mediated proteolysis
	Progesterone-mediated oocyte maturation

UniProtKB/Swiss-Prot: APC7_HUMAN, Q9UJX3

Pathway: Protein modification; protein ubiquitination

ANAPC7 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for ANAPC7

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/613 Interacting proteins for ANAPC7 (Q9UJX3^{2, 3} ENSP00000394394⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 613)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ANAPC1	Q9H1A4²^,³, ENSP00000339109⁴	MINT-8412994 MINT-7947479 I2D: score=2 STRING: ENSP00000339109
CDC16	Q13042²^,³, ENSP00000348554⁴	MINT-7947479 I2D: score=3 STRING: ENSP00000348554
ANAPC2	Q9UJX6²^,³, ENSP00000314004⁴	MINT-7947479 I2D: score=1 STRING: ENSP00000314004
CDC23	Q9UJX2²^,³, ENSP00000378350⁴	MINT-7947479 I2D: score=1 STRING: ENSP00000378350
CDC27	P30260²^,³	MINT-7947479 I2D: score=3

About this table

Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000075	cell cycle checkpoint	TAS	--
GO:0000278	mitotic cell cycle	TAS	--
GO:0007067	mitosis	IEA	--
GO:0007094	mitotic cell cycle spindle assembly checkpoint	TAS	--
GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process	TAS	--

ANAPC7 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ANAPC7
Search CenterWatch for drugs/clinical trials and news about ANAPC7 / APC7

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ANAPC7 gene (2 alternative transcripts):

NM_001137664.1 NM_016238.2

Unigene Cluster for ANAPC7:

Anaphase promoting complex subunit 7

Hs.719935 [show with all ESTs]

Unigene Representative Sequence: NM_016238

12 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000455511(uc001tqo.2) ENST00000481473 ENST00000552087 ENST00000547199

ENST00000486321 ENST00000452721 ENST00000450008(uc001tqp.4) ENST00000471602

ENST00000548234 ENST00000546720 ENST00000552170 ENST00000464697

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Additional cDNA sequence:

AF191340.1 AK021809.1 AL137586.1 AL157481.1 AY007104.1 BC002941.2 BC009498.2 BC017316.2

BC040130.1 BC098264.1 BC098295.1 BC098362.1 BC099732.1 BC111798.1 BC141848.1 BC148236.2

20 DOTS entries:

DT.444484 DT.99950552 DT.100782748 DT.102845358 DT.312557 DT.121216306 DT.40108271 DT.100841885

DT.75112546 DT.95280116 DT.100782749 DT.102845175 DT.121216056 DT.40308729 DT.75145156 DT.91812299

DT.92434849 DT.95230688 DT.100666390 DT.91941222

24/983 AceView cDNA sequences (see all 983):

AA593738 AI130955 BU786140 BQ230788 BF109961 BM840260 BM783382 CB240918

BQ005152 R23930 T30859 CD674462 BG574858 BQ882141 CD246073 BQ071452

AV654736 AI373621 BC002941 BQ893969 BM781474 AI203712 BM825147 BM503327

GeneLoc Exon Structure

5/11 Alternative Splicing Database (ASD) splice patterns (SP) for ANAPC7 (see all 11) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	^	2	^	3a	·	3b	·	3c	^	4a	·	4b	^	5	^	6a	·	6b	·	6c	^	7a	·	7b	^	8a	·	8b	^	9a	·	9b	·	9c	^	10	^	11a	·	11b	^	12a	·	12b	^
SP1:									-		-																-						-										-		-						-
SP2:									-		-																-						-										-		-
SP3:																											-
SP4:									-		-		-		-												-
SP5:									-		-								-

ExUns:	13a	·	13b	·	13c
SP1:
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for ANAPC7

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ANAPC7 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AACCAGAGGT

About this image
See ANAPC7 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ANAPC7

SOURCE GeneReport for Unigene cluster: Hs.719935

SABiosciences Expression via Pathway-Focused PCR Array including ANAPC7:

Ubiquitin Ligases in human mouse rat

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for ANAPC7 gene from 6/22 species (see all 22) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	ANAPC7¹	anaphase promoting complex subunit 7	82.06(n) 96.81(a)		416838 XM_415129.3 XP_415129.1
lizard (Anolis carolinensis)	Reptilia	--	--	91(a)	1 → many	LGb(2156453-2163663)
zebrafish (Danio rerio)	Actinopterygii	LOC558402¹	novel protein similar to vertebrate anaphase promoting more	75.58(n) 89.38(a)		558402 NM_001113585.1 NP_001107057.1
fruit fly (Drosophila melanogaster)	Insecta	Apc7¹	Anaphase promoting complex 7	40.44(n) 26.79(a)		31594 NM_132101.3 NP_572329.3
thale cress (Arabidopsis thaliana)	eudicotyledons	AT2G39090¹	anaphase-promoting complex subunit 7	44.15(n) 29.27(a)		818495 NM_179978.2 NP_850309.1
rice (Oryza sativa)	Liliopsida	Os05g0149900¹	hypothetical protein	41.27(n) 26.67(a)		4337822 NM_001061196.1 NP_001054661.2

ENSEMBL Gene Tree for ANAPC7 (if available)
TreeFam Gene Tree for ANAPC7 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ANAPC7 gene

ENSG00000258210²

1 SIMAP similar gene for ANAPC7 using alignment to 11 protein entries: APC7_HUMAN (see all proteins):

DKFZp762H177

ANAPC7 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 12 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs143247464^1,2		--	110810254(+)	`TCCTGC/GACAGC`	1	--	ds500¹		0	--	--	--	--
rs199558275^1,2		--	110810340(+)	`CTTTA-/TTTTTT`	1	--	ds500¹		0	--	--	--	--
rs147082419^1,2		--	110810453(+)	`CTGAGC/TATTGA`	1	--	ds500¹		0	--	--	--	--
rs116862125^1,2		--	110810454(+)	`TGAGTA/CTTGAG`	1	--	ds500¹		1		EA	120
rs114890469^1,2	F,	--	110810459(+)	`ATTGAG/ATAGCT`	1	--	ds500¹		1		WA	118
rs183064103^1,2		--	110810492(+)	`ATGCCC/TGGTTA`	1	--	ds500¹		0	--	--	--	--
rs187400714^1,2		--	110810845(+)	`TTTTGA/GATTTG`	1	--	ut3¹		0	--	--	--	--
rs191851189^1,2		--	110810857(+)	`GATTAA/GCTGTG`	1	--	ut3¹		0	--	--	--	--
rs184067954^1,2		--	110810904(+)	`GAGCCA/GTCGCA`	1	--	ut3¹		0	--	--	--	--
rs148019779^1,2		--	110810907(+)	`CCATCA/GCAACT`	1	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for ANAPC7 (110810705 - 110841535 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ANAPC7: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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ANAPC7 for disorders           About GeneDecksing

OMIM gene information: 606949    OMIM disorders: --

2 diseases for ANAPC7:    About MalaCards

carcinoma neuronitis

Export disorders for ANAPC7 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for ANAPC7 gene, integrated from 9 sources (see all 65):
(articles sorted by number of sources associating them with ANAPC7)

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Identification of a cullin homology region in a subunit of the anaphase-promoting complex. (PubMed id 9469815)^{1, 2, 9} Yu H.... Kirschner M.W. (1998)
Crystal structure of the N-terminal domain of anaphase-promoting complex subunit 7. (PubMed id 19091741)^{1, 2} Han D.... Kim Y. (2009)
Mechanism of ubiquitin-chain formation by the human anaphase-promoting complex. (PubMed id 18485873)^{1, 2} Jin L....Rape M. (2008)
Localization of the coactivator Cdh1 and the cullin subunit Apc2 in a cryo-electron microscopy model of vertebrate APC/C. (PubMed id 16364912)^{1, 2} Dube P.... Stark H. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
A census of human soluble protein complexes. (PubMed id 22939629)¹ Havugimana P.C....Emili A. (2012)
Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)¹ Woods N.T....Monteiro A.N. (2012)
The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)¹ Aichem A....Groettrup M. (2012)
Proteome-wide identification of ubiquitylation sites b y conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)¹ Oshikawa K....Nakayama K.I. (2012)
Proteasome-dependent disruption of the E3 ubiquitin li gase anaphase-promoting complex by HCMV protein pUL21a. (PubMed id 22792066)¹ Fehr A.R....Yu D. (2012)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 51434	HGNC: 17380	AceView: ARPC3andANAPC7	Ensembl:ENSG00000196510	euGenes: HUgn51434
ECgene: ANAPC7	Kegg: 51434	H-InvDB: ANAPC7

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for ANAPC7	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ANAPC7 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for ANAPC7 gene:
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GeneCards and IP:
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ANAPC7 Gene

anaphase promoting complex subunit 7

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ANAPC7 Gene

anaphase promoting complex subunit 7

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