Aliases for ANAPC7 Gene
External Ids for ANAPC7 Gene
Previous GeneCards Identifiers for ANAPC7 Gene
This gene encodes a tetratricopeptide repeat containing component of the anaphase promoting complex/cyclosome (APC/C), a large E3 ubiquitin ligase that controls cell cycle progression by targeting a number of cell cycle regulators such as B-type cyclins for 26S proteasome-mediated degradation through ubiquitination. The encoded protein is required for proper protein ubiquitination function of APC/C and for the interaction of APC/C with certain transcription coactivators. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2008]
GeneCards Summary for ANAPC7 Gene
ANAPC7 (Anaphase Promoting Complex Subunit 7) is a Protein Coding gene. Among its related pathways are Cellular Senescence and Cell cycle Role of SCF complex in cell cycle regulation. GO annotations related to this gene include protein phosphatase binding.
UniProtKB/Swiss-Prot for ANAPC7 Gene
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of Lys-11-linked polyubiquitin chains and, to a lower extent, the formation of Lys-48- and Lys-63-linked polyubiquitin chains.