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Aliases for ANAPC7 Gene

Aliases for ANAPC7 Gene

  • Anaphase Promoting Complex Subunit 7 2 3
  • Cyclosome Subunit 7 3 4
  • APC7 3 4
  • Anaphase-Promoting Complex Subunit 7 3

External Ids for ANAPC7 Gene

Summaries for ANAPC7 Gene

Entrez Gene Summary for ANAPC7 Gene

  • This gene encodes a tetratricopeptide repeat containing component of the anaphase promoting complex/cyclosome (APC/C), a large E3 ubiquitin ligase that controls cell cycle progression by targeting a number of cell cycle regulators such as B-type cyclins for 26S proteasome-mediated degradation through ubiquitination. The encoded protein is required for proper protein ubiquitination function of APC/C and for the interaction of APC/C with certain transcription coactivators. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2008]

GeneCards Summary for ANAPC7 Gene

ANAPC7 (Anaphase Promoting Complex Subunit 7) is a Protein Coding gene. Among its related pathways are Class I MHC mediated antigen processing and presentation and PAK Pathway. GO annotations related to this gene include protein phosphatase binding.

UniProtKB/Swiss-Prot for ANAPC7 Gene

  • Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of Lys-11-linked polyubiquitin chains and, to a lower extent, the formation of Lys-48- and Lys-63-linked polyubiquitin chains.

Gene Wiki entry for ANAPC7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANAPC7 Gene

Genomics for ANAPC7 Gene

Genomic Location for ANAPC7 Gene

Start:
110,372,900 bp from pter
End:
110,403,737 bp from pter
Size:
30,838 bases
Orientation:
Minus strand

Genomic View for ANAPC7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ANAPC7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANAPC7 Gene

Regulatory Elements for ANAPC7 Gene

Proteins for ANAPC7 Gene

  • Protein details for ANAPC7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UJX3-APC7_HUMAN
    Recommended name:
    Anaphase-promoting complex subunit 7
    Protein Accession:
    Q9UJX3
    Secondary Accessions:
    • Q96AC4
    • Q96GF4
    • Q9BU24
    • Q9NT16

    Protein attributes for ANAPC7 Gene

    Size:
    599 amino acids
    Molecular mass:
    66855 Da
    Quaternary structure:
    • V-shaped homodimer. The mammalian APC/C is composed of 14 distinct subunits that assemble into a complex of at least 19 chains with a combined molecular mass of around 1.2 MDa.
    SequenceCaution:
    • Sequence=AAH17316.2; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ANAPC7 Gene

    Alternative splice isoforms for ANAPC7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ANAPC7 Gene

Proteomics data for ANAPC7 Gene at MOPED

Post-translational modifications for ANAPC7 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys99, Lys115, Lys139, Lys193, Lys293, Lys306, Lys353, Lys364, Lys379, Lys467, Lys477, Lys482, and Lys491

Other Protein References for ANAPC7 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for ANAPC7 Gene

Domains for ANAPC7 Gene

Gene Families for ANAPC7 Gene

HGNC:
  • TTC :Tetratricopeptide (TTC) repeat domain containing
  • ANAPC :Anaphase promoting complex subunits

Protein Domains for ANAPC7 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UJX3

UniProtKB/Swiss-Prot:

APC7_HUMAN
Family:
  • Belongs to the APC7 family.:
    • Q9UJX3
Similarity:
  • Contains 10 TPR repeats.:
    • Q9UJX3
genes like me logo Genes that share domains with ANAPC7: view

Function for ANAPC7 Gene

Molecular function for ANAPC7 Gene

UniProtKB/Swiss-Prot Function: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of Lys-11-linked polyubiquitin chains and, to a lower extent, the formation of Lys-48- and Lys-63-linked polyubiquitin chains.

Gene Ontology (GO) - Molecular Function for ANAPC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0019903 protein phosphatase binding IPI 21241890
genes like me logo Genes that share ontologies with ANAPC7: view
genes like me logo Genes that share phenotypes with ANAPC7: view

miRNA for ANAPC7 Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ANAPC7 Gene

Localization for ANAPC7 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ANAPC7 Gene COMPARTMENTS Subcellular localization image for ANAPC7 gene
Compartment Confidence
nucleus 5
cytosol 4
mitochondrion 1

Gene Ontology (GO) - Cellular Components for ANAPC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21241890
GO:0005654 nucleoplasm TAS --
GO:0005680 anaphase-promoting complex IDA 16364912
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with ANAPC7: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ANAPC7 Gene

Pathways for ANAPC7 Gene

SuperPathways for ANAPC7 Gene

genes like me logo Genes that share pathways with ANAPC7: view

UniProtKB/Swiss-Prot Q9UJX3-APC7_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for ANAPC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle TAS --
GO:0007067 mitotic nuclear division IEA --
GO:0007094 mitotic spindle assembly checkpoint TAS --
GO:0031145 anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process TAS --
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with ANAPC7: view

Transcripts for ANAPC7 Gene

Unigene Clusters for ANAPC7 Gene

Anaphase promoting complex subunit 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ANAPC7 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b ^ 12a · 12b ^
SP1: - - - - - - -
SP2: - - - - - -
SP3: -
SP4: - - - - -
SP5: - - -
SP6: - -
SP7: - - -
SP8: - -
SP9: -
SP10:
SP11: - - -

ExUns: 13a · 13b · 13c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for ANAPC7 Gene

GeneLoc Exon Structure for
ANAPC7
ECgene alternative splicing isoforms for
ANAPC7

Expression for ANAPC7 Gene

mRNA expression in normal human tissues for ANAPC7 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ANAPC7 Gene

SOURCE GeneReport for Unigene cluster for ANAPC7 Gene Hs.719935

genes like me logo Genes that share expressions with ANAPC7: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ANAPC7 Gene

Orthologs for ANAPC7 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ANAPC7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ANAPC7 35
  • 99.78 (n)
  • 99.67 (a)
ANAPC7 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ANAPC7 35
  • 94.65 (n)
  • 97.32 (a)
ANAPC7 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ANAPC7 35
  • 95.48 (n)
  • 97.49 (a)
ANAPC7 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Anapc7 35
  • 88.79 (n)
  • 98.23 (a)
Anapc7 16
Anapc7 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ANAPC7 36
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ANAPC7 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Anapc7 35
  • 88.5 (n)
  • 98.41 (a)
chicken
(Gallus gallus)
Aves ANAPC7 35
  • 82.06 (n)
  • 96.81 (a)
ANAPC7 36
  • 95 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ANAPC7 36
  • 93 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia anapc7 35
  • 78.88 (n)
  • 94.34 (a)
zebrafish
(Danio rerio)
Actinopterygii anapc7 35
  • 75.58 (n)
  • 89.38 (a)
anapc7 36
  • 89 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003902 35
  • 45.4 (n)
  • 34.4 (a)
fruit fly
(Drosophila melanogaster)
Insecta Apc7 35
  • 40.64 (n)
  • 27.01 (a)
Apc7 36
  • 24 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G39090 35
  • 44.67 (n)
  • 30.8 (a)
rice
(Oryza sativa)
Liliopsida Os05g0149900 35
  • 41.51 (n)
  • 27.16 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 37 (a)
OneToOne
Species with no ortholog for ANAPC7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ANAPC7 Gene

ENSEMBL:
Gene Tree for ANAPC7 (if available)
TreeFam:
Gene Tree for ANAPC7 (if available)

Paralogs for ANAPC7 Gene

Selected SIMAP similar genes for ANAPC7 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with ANAPC7: view

No data available for Paralogs for ANAPC7 Gene

Variants for ANAPC7 Gene

Sequence variations from dbSNP and Humsavar for ANAPC7 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs4131850 -- 110,374,748(-) TGGGA(C/T)ACCTA intron-variant
rs4131851 -- 110,374,540(-) ACTCT(A/G)AAAAT intron-variant
rs4131852 -- 110,374,852(-) TCCTG(C/G)GGTCT intron-variant
rs6606746 -- 110,378,889(-) agagc(A/G)agact intron-variant
rs11554605 -- 110,375,877(+) ATGTT(A/G)TTAAT utr-variant-3-prime, intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ANAPC7 Gene

Variant ID Type Subtype PubMed ID
esv1001296 CNV Deletion 20482838

Relevant External Links for ANAPC7 Gene

HapMap Linkage Disequilibrium report
ANAPC7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANAPC7 Gene

Disorders for ANAPC7 Gene

No disorders were found for ANAPC7 Gene.

No data available for UniProtKB/Swiss-Prot for ANAPC7 Gene

Publications for ANAPC7 Gene

  1. Identification of a cullin homology region in a subunit of the anaphase-promoting complex. (PMID: 9469815) Yu H. … Kirschner M.W. (Science 1998) 3 4 23
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Localization of the coactivator Cdh1 and the cullin subunit Apc2 in a cryo-electron microscopy model of vertebrate APC/C. (PMID: 16364912) Dube P. … Stark H. (Mol. Cell 2005) 3 4
  4. Mechanism of ubiquitin-chain formation by the human anaphase- promoting complex. (PMID: 18485873) Jin L. … Rape M. (Cell 2008) 3 4
  5. Molecular architecture and mechanism of the anaphase-promoting complex. (PMID: 25043029) Chang L. … Barford D. (Nature 2014) 3 4

Products for ANAPC7 Gene

Sources for ANAPC7 Gene

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