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ANAPC7 Gene

protein-coding   GIFtS: 54
GCID: GC12M110810

Anaphase Promoting Complex Subunit 7

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Anaphase Promoting Complex Subunit 71 2
Cyclosome Subunit 72 3
APC72 3
Anaphase-Promoting Complex Subunit 72

External Ids:    HGNC: 173801   Entrez Gene: 514342   Ensembl: ENSG000001965107   OMIM: 6069495   UniProtKB: Q9UJX33   

Export aliases for ANAPC7 gene to outside databases

Previous GC identifers: GC12M9C0183 GC12P9H0002 GC12U900269 GC12M109274 GC12M109295 GC12M107829


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ANAPC7 Gene:
This gene encodes a tetratricopeptide repeat containing component of the anaphase promoting complex/cyclosome
(APC/C), a large E3 ubiquitin ligase that controls cell cycle progression by targeting a number of cell cycle
regulators such as B-type cyclins for 26S proteasome-mediated degradation through ubiquitination. The encoded
protein is required for proper protein ubiquitination function of APC/C and for the interaction of APC/C with
certain transcription coactivators. Multiple transcript variants encoding different isoforms have been found for
this gene. (provided by RefSeq, Nov 2008)

GeneCards Summary for ANAPC7 Gene:
ANAPC7 (anaphase promoting complex subunit 7) is a protein-coding gene. Diseases associated with ANAPC7 include phyllode tumor, and cytomegalovirus infection. GO annotations related to this gene include protein phosphatase binding.

UniProtKB/Swiss-Prot: APC7_HUMAN, Q9UJX3
Function: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin
ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by
mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of
'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked
polyubiquitin chains

Gene Wiki entry for ANAPC7 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the ANAPC7 gene promoter:
         Bach1   SREBP-1c   STAT1beta   Lmo2   GATA-1   SREBP-1b   RORalpha1   SREBP-1a   GATA-6   LyF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ANAPC7 promoter sequence
   Search Chromatin IP Primers for ANAPC7

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ANAPC7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.11   Ensembl cytogenetic band:  12q24.11   HGNC cytogenetic band: 12q13.12

ANAPC7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ANAPC7 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M110810:  view genomic region     (about GC identifiers)

Start:
110,810,705 bp from pter      End:
110,841,535 bp from pter
Size:
30,831 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: APC7_HUMAN, Q9UJX3 (See protein sequence)
Recommended Name: Anaphase-promoting complex subunit 7  
Size: 599 amino acids; 66855 Da
Subunit: Homodimer. The APC/C is composed of at least 12 subunits
Caution: It is uncertain whether Met-1 or Met-35 is the initiator
Sequence caution: Sequence=AAH17316.2; Type=Erroneous translation; Note=Wrong choice of frame;
1 PDB 3D structure from and Proteopedia for ANAPC7:
3FFL (3D)    
Secondary accessions: Q96AC4 Q96GF4 Q9BU24 Q9NT16
Alternative splicing: 2 isoforms:  Q9UJX3-1   Q9UJX3-2   

Explore the universe of human proteins at neXtProt for ANAPC7: NX_Q9UJX3

Explore proteomics data for ANAPC7 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys99, Lys115, Lys139, Lys193, Lys293, Lys306, Lys353, Lys364, Lys379, Lys467,
                                 Lys477, Lys482, Lys491
  • Modification sites at PhosphoSitePlus

  • See ANAPC7 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001131136.1  NP_057322.2  

    ENSEMBL proteins: 
     ENSP00000394394   ENSP00000450293   ENSP00000402314   ENSP00000450405  
    Reactome Protein details: Q9UJX3

    ANAPC7 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ANAPC: Anaphase promoting complex subunits
    TTC: Tetratricopeptide (TTC) repeat domain containing

    4 InterPro protein domains:
     IPR011990 TPR-like_helical
     IPR013105 TPR_2
     IPR013026 TPR-contain_dom
     IPR019734 TPR_repeat

    Graphical View of Domain Structure for InterPro Entry Q9UJX3

    ProtoNet protein and cluster: Q9UJX3

    UniProtKB/Swiss-Prot: APC7_HUMAN, Q9UJX3
    Similarity: Belongs to the APC7 family
    Similarity: Contains 7 TPR repeats


    ANAPC7 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: APC7_HUMAN, Q9UJX3
    Function: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin
    ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by
    mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of
    'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked
    polyubiquitin chains

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0019903protein phosphatase binding IPI--
         
    ANAPC7 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for ANAPC7:
     Downregulation of NF-kappaB pa  Downregulation of NF-kappaB pa  Increased cell death HMECs cel 

    Animal Models:
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    miRTarBase miRNAs that target ANAPC7:
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    Block miRNA regulation of human, mouse, rat ANAPC7 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ANAPC7 (see all 24):
    hsa-miR-3910 hsa-miR-3678-3p hsa-miR-4265 hsa-miR-185* hsa-miR-548k hsa-miR-139-5p hsa-miR-124 hsa-miR-298
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    Gene Editing
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANAPC7


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    mitochondrion1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005680anaphase-promoting complex IDA16364912
    GO:0005829cytosol TAS--

    ANAPC7 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ANAPC7 About   (see all 22)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Inactivation of APC/C via direct inhibition of the APC/C complex
    Inactivation of APC/C via direct inhibition of the APC/C complex0.64
    Mitotic Spindle Checkpoint0.62
    APC/C-Cdc20 mediated degradation of Cyclin B0.64
    Common schema of ubiquitination0.33
    Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components0.64
    2Class I MHC mediated antigen processing and presentation
    Class I MHC mediated antigen processing and presentation0.84
    Adaptive Immune System0.41
    Antigen processing- Ubiquitination and Proteasome degradation0.84
    Ubiquitin mediated proteolysis0.35
    3CDK-mediated phosphorylation and removal of Cdc6
    APC/C-mediated degradation of cell cycle proteins0.94
    Activation of APC/C and APC/C-Cdc20 mediated degradation of mitotic proteins0.92
    Regulation of mitotic cell cycle0.94
    Autodegradation of Cdh1 by Cdh1-APC/C0.91
    Regulation of APC/C activators between G1/S and early anaphase0.94
    Cell Cycle Checkpoints0.58
    APC/C-Cdc20 mediated degradation of Securin0.93
    Phosphorylation of the APC/C0.00
    4Mitotic Metaphase and Anaphase
    Mitotic Anaphase0.94
    Mitotic Metaphase and Anaphase0.93
    Separation of Sister Chromatids0.94
    5Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    M Phase0.62
    Cell Cycle0.90

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for ANAPC7 (see all 6)
        Activation of PKA through GPCR
    Remodeling of Adherens Junctions
    cAMP Pathway
    CDC42 Pathway
    Mitotic Roles of Polo Like Kinases

    Selected GeneGo (Thomson Reuters) Pathways for ANAPC7 (see all 7)
        Cell cycle Role of APC in cell cycle regulation
    G-protein signaling G-Protein alpha-s signaling cascades
    Signal transduction PKA signaling
    Cell cycle Regulation of G1/S transition (part 1)
    Cell cycle Spindle assembly and chromosome separation

    1 BioSystems Pathway for ANAPC7
        TGF-beta Receptor Signaling Pathway

    Selected Reactome Pathways for ANAPC7 (see all 12)
        APC/C:Cdc20 mediated degradation of mitotic proteins
    Autodegradation of Cdh1 by Cdh1:APC/C
    Phosphorylation of the APC/C
    Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
    APC/C:Cdc20 mediated degradation of Securin


    5 Kegg Pathways  (Kegg details for ANAPC7):
        Cell cycle
    Oocyte meiosis
    Ubiquitin mediated proteolysis
    Progesterone-mediated oocyte maturation
    HTLV-I infection

    UniProtKB/Swiss-Prot: APC7_HUMAN, Q9UJX3
    Pathway: Protein modification; protein ubiquitination


    ANAPC7 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including ANAPC7: 

              Ubiquitin Ligases in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for ANAPC7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ANAPC7 (Q9UJX32, 3 ENSP000003943944) via UniProtKB, MINT, STRING, and/or I2D (see all 642)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ANAPC1Q9H1A42, 3, ENSP000003391094MINT-8412994 MINT-7947479 I2D: score=2 STRING: ENSP00000339109
    CDC16Q130422, 3, ENSP000003485544MINT-7947479 I2D: score=3 STRING: ENSP00000348554
    ANAPC2Q9UJX62, 3, ENSP000003140044MINT-7947479 I2D: score=1 STRING: ENSP00000314004
    CDC23Q9UJX22, 3, ENSP000003783504MINT-7947479 I2D: score=1 STRING: ENSP00000378350
    CDC27P302602, 3MINT-7947479 I2D: score=3 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000278mitotic cell cycle TAS--
    GO:0007067mitosis IEA--
    GO:0007094mitotic spindle assembly checkpoint TAS--
    GO:0031145anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process TAS--
    GO:0051436negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle TAS--

    ANAPC7 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ANAPC7 (APC7)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ANAPC7 gene (2 alternative transcripts): 
    NM_001137664.1  NM_016238.2  

    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000455511(uc001tqo.2) ENST00000481473 ENST00000552087 ENST00000486321
    ENST00000452721 ENST00000450008(uc001tqp.4) ENST00000471602 ENST00000547199
    ENST00000548234 ENST00000546720 ENST00000552170 ENST00000464697
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    Selected qRT-PCR Assays for microRNAs that regulate ANAPC7 (see all 24):
    hsa-miR-3910 hsa-miR-3678-3p hsa-miR-4265 hsa-miR-185* hsa-miR-548k hsa-miR-139-5p hsa-miR-124 hsa-miR-298
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      QuantiFast Probe-based Assays in human, mouse, rat ANAPC7

    Selected AceView cDNA sequences (see all 983):

    AW160362 AA593738 AI621325 BM841517 BE910721 BC002941 CA773264 BM743505 
    AI571341 BF055066 CD369701 BM985018 BG825894 CR407667 BM557165 BM503327 
    AI929833 BG387564 BU508371 BQ071452 BM840260 NM_005719 BM761504 BQ221283 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ANAPC7 (see all 11)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b ^ 12a · 12b ^
    SP1:                          -     -                                               -                 -                             -     -                 -   
    SP2:                          -     -                                               -                 -                             -     -                     
    SP3:                                                                                -                                                                           
    SP4:                          -     -     -     -                                   -                                                                           
    SP5:                          -     -                       -                                                                                                   

    ExUns: 13a · 13b · 13c
    SP1:                  
    SP2:                  
    SP3:                  
    SP4:                  
    SP5:                  


    ECgene alternative splicing isoforms for ANAPC7

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    ANAPC7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AACCAGAGGT
    ANAPC7 Expression
    About this image

    ANAPC7 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ANAPC7 Protein Expression
        Pathway & Disease-focused RT2 Profiler PCR Array including ANAPC7: 
              Ubiquitin Ligases in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANAPC7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ANAPC7 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Anapc71 , 5 anaphase promoting complex subunit 71, 5 88.79(n)1
    98.23(a)1
      5 (62.36 cM)5
    563171  NM_019805.41  NP_062779.31 
     1224216935 
    chicken
    (Gallus gallus)
    Aves ANAPC71 anaphase promoting complex subunit 7 82.06(n)
    96.81(a)
      416838  XM_415129.4  XP_415129.1 
    lizard
    (Anolis carolinensis)
    Reptilia ANAPC76
    anaphase promoting complex subunit 7
    93(a)
    1 ↔ 1
    LGb(2155741-2173913)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia anapc71 anaphase promoting complex subunit 7 78.88(n)
    94.34(a)
      549081  NM_001016327.2  NP_001016327.1 
    zebrafish
    (Danio rerio)
    Actinopterygii anapc71 anaphase promoting complex subunit 7 75.58(n)
    89.38(a)
      558402  NM_001113585.1  NP_001107057.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Apc71 Anaphase promoting complex 7 40.64(n)
    27.01(a)
      31594  NM_132101.3  NP_572329.3 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT2G390901 AT2G39090 44.67(n)
    30.8(a)
      818495  NM_179978.2  NP_850309.1 
    rice
    (Oryza sativa)
    Liliopsida Os05g01499001 Os05g0149900 41.51(n)
    27.16(a)
      4337822  NM_001061196.1  NP_001054661.2 


    ENSEMBL Gene Tree for ANAPC7 (if available)
    TreeFam Gene Tree for ANAPC7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ANAPC7 gene
    1 SIMAP similar gene for ANAPC7 using alignment to 7 protein entries:     APC7_HUMAN (see all proteins):
    DKFZp762H177

    ANAPC7 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for ANAPC7 (see all 704)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1432474641,2
    --110810254(+) TCCTGC/GACAGC 1 -- ds50010--------
    rs1995582751,2
    --110810340(+) CTTTA-/TTTTTT 1 -- ds50010--------
    rs1470824191,2
    --110810453(+) CTGAGC/TATTGA 1 -- ds50010--------
    rs1168621251,2
    F--110810454(+) TGAGTA/CTTGAG 1 -- ds50011Minor allele frequency- C:0.01EA 120
    rs1148904691,2
    F--110810459(+) ATTGAG/ATAGCT 1 -- ds50011Minor allele frequency- A:0.04WA 118
    rs1830641031,2
    --110810492(+) ATGCCC/TGGTTA 1 -- ds50010--------
    rs1874007141,2
    --110810845(+) TTTTGA/GATTTG 1 -- ut310--------
    rs1918511891,2
    --110810857(+) GATTAA/GCTGTG 1 -- ut310--------
    rs1840679541,2
    --110810904(+) GAGCCA/GTCGCA 1 -- ut310--------
    rs1480197791,2
    C--110810907(+) CCATCA/GCAACT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for ANAPC7 (110810705 - 110841535 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for ANAPC7:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1001296CNV Deletion20482838

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ANAPC7
    DNA2.0 Custom Variant and Variant Library Synthesis for ANAPC7

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606949    OMIM disorders: --

    6 diseases for ANAPC7:    
    About MalaCards
    phyllode tumor    cytomegalovirus infection    brain cancer    hiv-1
    malaria    neuronitis


    ANAPC7 for disorders           About GeneDecksing


    Export disorders for ANAPC7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ANAPC7 gene, integrated from 10 sources (see all 77):
    (articles sorted by number of sources associating them with ANAPC7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a cullin homology region in a subunit of the anaphase-promoting complex. (PubMed id 9469815)1, 2, 9 Yu H.... Kirschner M.W. (Science 1998)
    2. Crystal structure of the N-terminal domain of anaphase-promoting complex subunit 7. (PubMed id 19091741)1, 2 Han D.... Kim Y. (J. Biol. Chem. 2009)
    3. Mechanism of ubiquitin-chain formation by the human anaphase- promoting complex. (PubMed id 18485873)1, 2 Jin L.... Rape M. (Cell 2008)
    4. Localization of the coactivator Cdh1 and the cullin subunit Apc2 in a cryo-electron microscopy model of vertebrate APC/C. (PubMed id 16364912)1, 2 Dube P.... Stark H. (Mol. Cell 2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Recombinant expression, reconstitution and structure of human anaphase-promoting complex (APC/C). (PubMed id 23078409)1 Zhang Z....Barford D. (Biochem. J. 2013)
    7. The G2/M regulator histone demethylase PHF8 is targeted for degradation by the anaphase-promoting complex containing CDC20. (PubMed id 23979597)1 Lim H.J....Shi Y. (Mol. Cell. Biol. 2013)
    8. Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes? (PubMed id 23314748)1 Nathan J.A....Goldberg A.L. (EMBO J. 2013)
    9. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    10. Transcriptional intermediary factor 1I^ binds to the anaphase-promoting complex/cyclosome and promotes mitosis. (PubMed id 23160376)1 Sedgwick G.G....Turnell A.S. (Oncogene 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 51434 HGNC: 17380 AceView: ARPC3andANAPC7 Ensembl:ENSG00000196510 euGenes: HUgn51434
    ECgene: ANAPC7 Kegg: 51434 H-InvDB: ANAPC7

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ANAPC7 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for ANAPC7 gene:
    Search GeneIP for patents involving ANAPC7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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