Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



ANAPC5 Gene

protein-coding   GIFtS: 60
GCID: GC12M121746

Anaphase Promoting Complex Subunit 5

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Anaphase Promoting Complex Subunit 51 2
APC52 3 5
Cyclosome Subunit 52 3
Anaphase-Promoting Complex Subunit 52

External Ids:    HGNC: 157131   Entrez Gene: 514332   Ensembl: ENSG000000890537   OMIM: 6069485   UniProtKB: Q9UJX43   

Export aliases for ANAPC5 gene to outside databases

Previous GC identifers: GC12M120611 GC12M121326 GC12M121529 GC12M120158 GC12M120208 GC12M118756


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for ANAPC5 Gene:
This gene encodes a tetratricopeptide repeat-containing component of the anaphase promoting complex/cyclosome
(APC/C), a large E3 ubiquitin ligase that controls cell cycle progression by targeting a number of cell cycle
regulators such as B-type cyclins for 26S proteasome-mediated degradation through ubiquitination. The encoded
protein is required for the proper ubiquitination function of APC/C and for the interaction of APC/C with
transcription coactivators. It also interacts with polyA binding protein and represses internal ribosome entry
site-mediated translation. Multiple transcript variants encoding different isoforms have been found for this
gene. These differences cause translation initiation at a downstream AUG and result in a shorter protein (isoform
b), compared to isoform a. (provided by RefSeq, Nov 2008)

GeneCards Summary for ANAPC5 Gene:
ANAPC5 (anaphase promoting complex subunit 5) is a protein-coding gene. Diseases associated with ANAPC5 include cytomegalovirus infection, and brain cancer. GO annotations related to this gene include ubiquitin-protein ligase activity and protein phosphatase binding.

UniProtKB/Swiss-Prot: APC5_HUMAN, Q9UJX4
Function: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin
ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by
mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of
'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked
polyubiquitin chains

Gene Wiki entry for ANAPC5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000012.12  NT_029419.13  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ANAPC5 gene promoter:
         HOXA9   PPAR-gamma1   PPAR-gamma2   MIF-1   POU3F2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 6): ANAPC5 promoter sequence
   Search Chromatin IP Primers for ANAPC5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ANAPC5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.31   Ensembl cytogenetic band:  12q24.31   HGNC cytogenetic band: 12q24

ANAPC5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ANAPC5 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M121746:  view genomic region     (about GC identifiers)

Start:
121,746,048 bp from pter      End:
121,837,699 bp from pter
Size:
91,652 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: APC5_HUMAN, Q9UJX4 (See protein sequence)
Recommended Name: Anaphase-promoting complex subunit 5  
Size: 755 amino acids; 85077 Da
Subunit: The APC/C is composed of at least 12 subunits
Secondary accessions: E9PFB2 Q8N4H7 Q9BQD4
Alternative splicing: 3 isoforms:  Q9UJX4-1   Q9UJX4-2   Q9UJX4-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ANAPC5: NX_Q9UJX4

Explore proteomics data for ANAPC5 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys224, Lys229, Lys238, Lys289, Lys403, Lys669
  • Modification sites at PhosphoSitePlus

  • See ANAPC5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001131031.1  NP_057321.2  

    ENSEMBL proteins: 
     ENSP00000437857   ENSP00000415061   ENSP00000439875   ENSP00000261819   ENSP00000438754  
     ENSP00000440800   ENSP00000445191   ENSP00000441508   ENSP00000343787   ENSP00000445310  
    Reactome Protein details: Q9UJX4

    ANAPC5 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for ANAPC5
    OriGene Protein Over-expression Lysate for ANAPC5
    OriGene MassSpec for ANAPC5
    OriGene Custom Protein Services for ANAPC5
    GenScript Custom Purified and Recombinant Proteins Services for ANAPC5
    Novus Biologicals ANAPC5 Proteins
    Novus Biologicals ANAPC5 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ANAPC5

    ANAPC5 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for ANAPC5
    OriGene Custom Antibody Services for ANAPC5
    Novus Biologicals ANAPC5 Antibodies
    Abcam antibodies for ANAPC5
    Cloud-Clone Corp. Antibodies for ANAPC5
    ThermoFisher Antibodies for ANAPC5
    LSBio Antibodies in human, mouse, rat for ANAPC5

    ANAPC5 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ANAPC5
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ANAPC5
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ANAPC5
    Cloud-Clone Corp. CLIAs for ANAPC5


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    ANAPC: Anaphase promoting complex subunits

    2 InterPro protein domains:
     IPR011990 TPR-like_helical
     IPR026000 Apc5/TPR19_dom

    Graphical View of Domain Structure for InterPro Entry Q9UJX4

    ProtoNet protein and cluster: Q9UJX4

    UniProtKB/Swiss-Prot: APC5_HUMAN, Q9UJX4
    Similarity: Belongs to the APC5 family
    Similarity: Contains 4 TPR repeats


    ANAPC5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: APC5_HUMAN, Q9UJX4
    Function: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin
    ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by
    mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of
    'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked
    polyubiquitin chains

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity TAS9469815
    GO:0005515protein binding ----
    GO:0019903protein phosphatase binding IPI--
         
    ANAPC5 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for ANAPC5:
     Increased cell death HMECs cel  Increased cell death in breast 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ANAPC5
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ANAPC5

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ANAPC5
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ANAPC5

    miRNA
    Products:
        
    miRTarBase miRNAs that target ANAPC5:
    hsa-mir-30a-5p (MIRT049952), hsa-mir-124-3p (MIRT022451), hsa-mir-26b-3p (MIRT038955), hsa-mir-1227-3p (MIRT036395), hsa-mir-93-5p (MIRT048874), hsa-mir-34a-5p (MIRT047361)

    Block miRNA regulation of human, mouse, rat ANAPC5 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate ANAPC5:
    hsa-miR-3065-5p
    SwitchGear 3'UTR luciferase reporter plasmidANAPC5 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ANAPC5
    Predesigned siRNA for gene silencing in human, mouse, rat ANAPC5

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ANAPC5

    Clone
    Products:
         
    OriGene clones in human, mouse for ANAPC5 (see all 12)
    OriGene ORF clones in mouse, rat for ANAPC5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): ANAPC5 (NM_016237)
    Sino Biological Human cDNA Clone for ANAPC5
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ANAPC5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ANAPC5

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ANAPC5
    Browse ESI BIO Cell Lines and PureStem Progenitors for ANAPC5 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANAPC5


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    golgi apparatus1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005680anaphase-promoting complex IDA16364912
    GO:0005829cytosol TAS--

    ANAPC5 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for ANAPC5 About   (see all 22)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Inactivation of APC/C via direct inhibition of the APC/C complex
    Inactivation of APC/C via direct inhibition of the APC/C complex0.64
    Mitotic Spindle Checkpoint0.62
    APC/C-Cdc20 mediated degradation of Cyclin B0.64
    Common schema of ubiquitination0.33
    Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components0.64
    2Class I MHC mediated antigen processing and presentation
    Class I MHC mediated antigen processing and presentation0.84
    Adaptive Immune System0.41
    Antigen processing- Ubiquitination and Proteasome degradation0.84
    Ubiquitin mediated proteolysis0.35
    3CDK-mediated phosphorylation and removal of Cdc6
    APC/C-mediated degradation of cell cycle proteins0.94
    Activation of APC/C and APC/C-Cdc20 mediated degradation of mitotic proteins0.92
    Regulation of mitotic cell cycle0.94
    Autodegradation of Cdh1 by Cdh1-APC/C0.91
    Regulation of APC/C activators between G1/S and early anaphase0.94
    Cell Cycle Checkpoints0.58
    APC/C-Cdc20 mediated degradation of Securin0.93
    Phosphorylation of the APC/C0.00
    4Mitotic Metaphase and Anaphase
    Mitotic Anaphase0.94
    Mitotic Metaphase and Anaphase0.93
    Separation of Sister Chromatids0.94
    5Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    M Phase0.62
    Cell Cycle0.90

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for ANAPC5 (see all 6)
        Activation of PKA through GPCR
    Remodeling of Adherens Junctions
    cAMP Pathway
    CDC42 Pathway
    Mitotic Roles of Polo Like Kinases

    Selected GeneGo (Thomson Reuters) Pathways for ANAPC5 (see all 7)
        Cell cycle Role of APC in cell cycle regulation
    G-protein signaling G-Protein alpha-s signaling cascades
    Signal transduction PKA signaling
    Cell cycle Regulation of G1/S transition (part 1)
    Cell cycle Spindle assembly and chromosome separation

    1 BioSystems Pathway for ANAPC5
        TGF-beta Receptor Signaling Pathway


    Selected Reactome Pathways for ANAPC5 (see all 12)
        APC/C:Cdc20 mediated degradation of mitotic proteins
    Autodegradation of Cdh1 by Cdh1:APC/C
    Phosphorylation of the APC/C
    Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
    APC/C:Cdc20 mediated degradation of Securin


    5 Kegg Pathways  (Kegg details for ANAPC5):
        Cell cycle
    Oocyte meiosis
    Ubiquitin mediated proteolysis
    Progesterone-mediated oocyte maturation
    HTLV-I infection

    UniProtKB/Swiss-Prot: APC5_HUMAN, Q9UJX4
    Pathway: Protein modification; protein ubiquitination


    ANAPC5 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including ANAPC5: 

              Ubiquitin Ligases in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for ANAPC5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ANAPC5 (Q9UJX42, 3 ENSP000002618194) via UniProtKB, MINT, STRING, and/or I2D (see all 184)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ZBTB16Q055162, 3, ENSP000003381574MINT-65751 I2D: score=5 STRING: ENSP00000338157
    MAPK6Q166592, 3MINT-8260669 I2D: score=2 
    ENSG00000206481Q146763, ENSP000003730604I2D: score=1 STRING: ENSP00000373060
    ENSG00000224587Q146763I2D: score=1 
    ENSG00000225589Q146763I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000086G2/M transition of mitotic cell cycle TAS9469815
    GO:0000090mitotic anaphase TAS9469815
    GO:0000278mitotic cell cycle TAS--
    GO:0006511ubiquitin-dependent protein catabolic process TAS9469815
    GO:0007067mitosis IEA--

    ANAPC5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ANAPC5 (APC5)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for ANAPC5 gene (2 alternative transcripts): 
    NM_001137559.1  NM_016237.4  

    Unigene Cluster for ANAPC5:

    Anaphase promoting complex subunit 5
    Hs.7101  [show with all ESTs]
    Unigene Representative Sequence: NM_016237
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 24):
    ENST00000422342 ENST00000535641(uc001uae.3) ENST00000539079(uc001uaf.3)
    ENST00000441917(uc001uah.3) ENST00000534976 ENST00000541887 ENST00000261819(uc010szv.2 uc001uag.3)
    ENST00000535482(uc010szu.2) ENST00000544314 ENST00000545218 ENST00000366333
    ENST00000535472 ENST00000538334 ENST00000535463 ENST00000538223 ENST00000539612
    ENST00000541652 ENST00000544442
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ANAPC5 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate ANAPC5:
    hsa-miR-3065-5p
    SwitchGear 3'UTR luciferase reporter plasmidANAPC5 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ANAPC5
    Predesigned siRNA for gene silencing in human, mouse, rat ANAPC5
    Clone
    Products:
         
    OriGene clones in human, mouse for ANAPC5 (see all 12)
    OriGene ORF clones in mouse, rat for ANAPC5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): ANAPC5 (NM_016237)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ANAPC5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ANAPC5
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for ANAPC5
    OriGene qSTAR qPCR primer pairs in human, mouse for ANAPC5
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ANAPC5
      QuantiTect SYBR Green Assays in human, mouse, rat ANAPC5
      QuantiFast Probe-based Assays in human, mouse, rat ANAPC5

    Additional mRNA sequence: 

    AF191339.1 AK025614.1 AK054779.1 AK294139.1 AK301197.1 AK315451.1 BC001081.2 BC001950.1 
    BC003095.1 BC006301.2 BC034243.1 BX537687.1 

    Selected DOTS entries (see all 35):

    DT.100678453  DT.91776083  DT.447171  DT.100678448  DT.100678455  DT.95070195  DT.97860680  DT.95070179 
    DT.121164737  DT.100638763  DT.40223869  DT.121164919  DT.40107121  DT.100678457  DT.91872681  DT.91951806 
    DT.91962906  DT.100733870  DT.91776084  DT.92340179  DT.100039495  DT.100678445  DT.100678450  DT.121164723 

    Selected AceView cDNA sequences (see all 744):

    AV726571 BG675147 BE208447 BQ424548 BQ020132 BM559232 BQ690984 BQ946840 
    BM827135 BM717017 BE219770 AA283089 AI859927 AA985638 AI372982 T17500 
    BC001950 BC003095 BM852780 AA100221 BX356750 BM766351 CK725186 BQ433025 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ANAPC5 (see all 20)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e · 2f ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b · 11c ^ 12a · 12b ·
    SP1:        -     -     -     -     -     -     -           -           -     -     -     -                                                                     
    SP2:                                            -           -           -     -     -     -                                                                     
    SP3:                                                                                                                                                  -     -   
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 12c ^ 13a · 13b · 13c · 13d ^ 14a · 14b · 14c · 14d · 14e · 14f ^ 15a · 15b · 15c · 15d ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21a · 21b ^ 22 ^ 23a · 23b ·
    SP1:  -     -     -                 -     -           -     -     -     -     -                 -                                   -     -                     
    SP2:  -     -     -                                   -     -     -     -     -                 -                                   -     -                     
    SP3:  -     -     -     -     -                       -     -     -     -     -                 -                                   -                           
    SP4:                                                                                            -                                   -     -                     
    SP5:  -     -     -                 -                                                                                                                           


    ECgene alternative splicing isoforms for ANAPC5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    ANAPC5 expression in normal human tissues (normalized intensities)      ANAPC5 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCCCCTCTCT
    ANAPC5 Expression
    About this image


    ANAPC5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 17) fully expand
     
     Thymus (Hematopoietic System)
             Double Negative 2 Thymocytes Thymus
     
     Blood (Cardiovascular System)
             Double Negative 2 Thymocytes Thymus
     
     Brain (Nervous System)
             Cerebral Cortex
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Colon (Gastrointestinal Tract)
    ANAPC5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ANAPC5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.7101
        Pathway & Disease-focused RT2 Profiler PCR Array including ANAPC5: 
              Ubiquitin Ligases in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for ANAPC5
    OriGene qSTAR qPCR primer pairs in human, mouse for ANAPC5
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ANAPC5
    QuantiTect SYBR Green Assays in human, mouse, rat ANAPC5
    QuantiFast Probe-based Assays in human, mouse, rat ANAPC5
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANAPC5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ANAPC5 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Anapc51 , 5 anaphase-promoting complex subunit 51, 5 90.05(n)1
    94.73(a)1
      5 (62.58 cM)5
    590081  NM_021505.21  NP_067480.21 
     1227874695 
    chicken
    (Gallus gallus)
    Aves ANAPC51 anaphase promoting complex subunit 5 78.46(n)
    85.77(a)
      416842  NM_001006187.1  NP_001006187.1 
    lizard
    (Anolis carolinensis)
    Reptilia ANAPC56
    anaphase promoting complex subunit 5
    83(a)
    1 ↔ 1
    AAWZ02041481(1950-4965)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.117722 Transcribed sequence with weak similarity to protein more 79.1(n)    BX719854.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb75a092 wufb75a09 75.71(n)   322854  BC045458.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta ida1 imaginal discs arrested 40.67(n)
    28.07(a)
      45574  NM_139580.3  NP_647837.2 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G065901 AT1G06590 42.53(n)
    31.17(a)
      837170  NM_100538.4  NP_172146.2 


    ENSEMBL Gene Tree for ANAPC5 (if available)
    TreeFam Gene Tree for ANAPC5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for ANAPC5 (see all 996)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0357934
    A breast cancer sample4--see VAR_0357932 Q H mis40--------
    rs1467325461,2
    --121745551(+) CTGCTA/GGGATT 2 -- ds50010--------
    rs1837205461,2
    C--121745625(+) TGGACA/GTAATT 2 -- ds50010--------
    rs26863571,2
    C--121745742(+) ATTGGT/GCCAAA 2 -- ds50012Minor allele frequency- G:0.00NA 4
    rs1403157591,2
    --121745794(+) ACCAAC/TAAGTC 2 -- ds50010--------
    rs1881915401,2
    --121745802(+) GTCCTC/TGTGAG 2 -- ds50010--------
    rs1453545801,2
    --121745816(+) CCACAG/TGAACC 2 -- ds50010--------
    rs748206481,2
    C,F--121745828(+) CAAGCG/ACTGGT 2 -- ds50011Minor allele frequency- A:0.06EA 120
    rs1119404711,2
    F--121745837(+) GTTCAG/CTCCAA 2 -- ds50012Minor allele frequency- C:0.50CSA 4
    rs1929588761,2
    --121745941(+) TCTGAA/GAATAG 2 -- ds50010--------

    HapMap Linkage Disequilibrium report for ANAPC5 (121746048 - 121837699 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for ANAPC5:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv521928CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ANAPC5
    DNA2.0 Custom Variant and Variant Library Synthesis for ANAPC5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 606948    OMIM disorders: --

    6 diseases for ANAPC5:    About MalaCards
    cytomegalovirus infection    brain cancer    breast and colorectal cancer    colorectal cancer
    malaria    neuronitis


    ANAPC5 for disorders           About GeneDecksing


    Export disorders for ANAPC5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for ANAPC5 gene, integrated from 10 sources (see all 68):
    (articles sorted by number of sources associating them with ANAPC5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a cullin homology region in a subunit of the anaphase-promoting complex. (PubMed id 9469815)1, 2, 3, 9 Yu H.... Kirschner M.W. (Science 1998)
    2. Mechanism of ubiquitin-chain formation by the human anaphase- promoting complex. (PubMed id 18485873)1, 2 Jin L.... Rape M. (Cell 2008)
    3. Localization of the coactivator Cdh1 and the cullin subunit Apc2 in a cryo-electron microscopy model of vertebrate APC/C. (PubMed id 16364912)1, 2 Dube P.... Stark H. (Mol. Cell 2005)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Mitotic regulation of the human anaphase-promoting complex by phosphorylation. (PubMed id 14657031)1, 2 Kraft C....Peters J.-M. (EMBO J. 2003)
    7. Expression of anaphase-promoting complex 5 in balloon angioplasty-injured rat carotid arteries and mitogen-stimulated human vascular smooth muscle cells. (PubMed id 11401522)1, 9 Autieri M.V. (Biochem. Biophys. Res. Commun. 2001)
    8. Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. (PubMed id 24255178)1 Couzens A.L....Gingras A.C. (Sci Signal 2013)
    9. The G2/M regulator histone demethylase PHF8 is targeted for degradation by the anaphase-promoting complex containing CDC20. (PubMed id 23979597)1 Lim H.J....Shi Y. (Mol. Cell. Biol. 2013)
    10. Transcriptional intermediary factor 1I^ binds to the anaphase-promoting complex/cyclosome and promotes mitosis. (PubMed id 23160376)1 Sedgwick G.G....Turnell A.S. (Oncogene 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 51433 HGNC: 15713 AceView: ANAPC5 Ensembl:ENSG00000089053 euGenes: HUgn51433
    ECgene: ANAPC5 Kegg: 51433 H-InvDB: ANAPC5

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for ANAPC5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for ANAPC5 gene:
    Search GeneIP for patents involving ANAPC5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for ANAPC5   OriGene RNAi products in human, mouse, rat for ANAPC5  
     OriGene qPCR primer pairs and template standards for ANAPC5   OriGene Protein Over-expression Lysate for ANAPC5  
     OriGene MassSpec something-or-other for ANAPC5   OriGene clones in human, mouse for ANAPC5  
     OriGene qSTAR qPCR primer pairs in human, mouse for ANAPC5   OriGene Purified Protein for ANAPC5  
     OriGene ORF clones in mouse, rat for ANAPC5   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ANAPC5   OriGene Custom Protein Services for ANAPC5  

     
     
     Block miRNA regulation of human, mouse, rat ANAPC5 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing ANAPC5
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ANAPC5 Predesigned siRNA for gene silencing in human, mouse, rat ANAPC5
     QuantiFast Probe-based Assays in human, mouse, rat ANAPC5 QuantiTect SYBR Green Assays in human, mouse, rat ANAPC5
     PCR Arrays including human, mouse, rat ANAPC5 Search Chromatin IP Primers for ANAPC5
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ANAPC5  Search GeneGlobe Interaction Network for ANAPC5
     Regulatory tfbs in ANAPC5 promoter
     GenScript Custom Purified and Recombinant Proteins Services for ANAPC5 GenScript cDNA clones with any tag delivered in your preferred vector for ANAPC5
     GenScript Custom Assay Services for ANAPC5 GenScript Custom overexpressing Cell Line Services for ANAPC5
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for ANAPC5 (APC5)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for ANAPC5
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     ANAPC5 antibodies
     ANAPC5 proteins
     ANAPC5 lysates
     Antibodies for ANAPC5
     See all of Abcam's Antibodies, Kits and Proteins for ANAPC5
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for ANAPC5
     Antibodies for ANAPC5
     ELISAs for ANAPC5
     CLIAs for ANAPC5



     Browse ESI BIO Cell Lines and PureStem Progenitors for ANAPC5
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANAPC5
     SwitchGear 3'UTR luciferase reporter plasmids for ANAPC5
     SwitchGear Promoter luciferase reporter plasmids for ANAPC5
     ThermoFisher Antibodies for ANAPC5
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ANAPC5
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ANAPC5
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ANAPC5
     LSBio Antibodies in human, mouse, rat for ANAPC5
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      ANAPC5 gene at Home site.
    Version: 3.12.136 22 July 2014
    hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4