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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ANAPC5 Gene

protein-coding GIFtS: 55
GCID: GC12M121746

anaphase promoting complex subunit 5

Explore 2 diseases affiliated with
ANAPC5 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Anaphase Promoting Complex Subunit 5¹ ²
APC5¹ ² ³ ⁵
Cyclosome Subunit 5² ³
Anaphase-Promoting Complex Subunit 5²

External Ids:	HGNC: 15713¹	Entrez Gene: 51433²	Ensembl: ENSG00000089053⁷	OMIM: 606948⁵	UniProtKB: Q9UJX4³

Export aliases for ANAPC5 gene to outside databases

Previous GC identifers: GC12M120611 GC12M121326 GC12M121529 GC12M120158 GC12M120208 GC12M118756

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ANAPC5:

This gene encodes a tetratricopeptide repeat-containing component of the anaphase promoting complex/cyclosome (APC/C),

a large E3 ubiquitin ligase that controls cell cycle progression by targeting a number of cell cycle regulators such

as B-type cyclins for 26S proteasome-mediated degradation through ubiquitination. The encoded protein is required for

the proper ubiquitination function of APC/C and for the interaction of APC/C with transcription coactivators. It also

interacts with polyA binding protein and represses internal ribosome entry site-mediated translation. Multiple

transcript variants encoding different isoforms have been found for this gene. These differences cause translation

initiation at a downstream AUG and result in a shorter protein (isoform b), compared to isoform a. (provided by

RefSeq, Nov 2008)

UniProtKB/Swiss-Prot: APC5_HUMAN, Q9UJX4

Function: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase

that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating

ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked

polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains

Gene Wiki entry for ANAPC5

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000012.11 NC_018923.1 NT_009775.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ANAPC5 gene promoter:
HOXA9 PPAR-gamma1 PPAR-gamma2 MIF-1 POU3F2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 6): ANAPC5 promoter sequence

Search SABiosciences Chromatin IP Primers for ANAPC5

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ANAPC5

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.31 Ensembl cytogenetic band: 12q24.31 HGNC cytogenetic band: 12q24

ANAPC5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ANAPC5 gene location

GeneLoc information about chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12M121746: view genomic region (about GC identifiers)

Start:	121,746,048 bp from pter	End:	121,837,699 bp from pter
Size:	91,652 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: APC5_HUMAN, Q9UJX4 (See protein sequence)

Recommended Name: Anaphase-promoting complex subunit 5

Size: 755 amino acids; 85077 Da

Subunit: The APC/C is composed of at least 12 subunits

Secondary accessions: E9PFB2 Q8N4H7 Q9BQD4

Alternative splicing: 3 isoforms: Q9UJX4-1 Q9UJX4-2 Q9UJX4-3 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ANAPC5: NX_Q9UJX4

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9UJX4

ANAPC5 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001131031.1 NP_057321.2

ENSEMBL proteins:

ENSP00000437857 ENSP00000415061 ENSP00000439875 ENSP00000261819 ENSP00000438754

ENSP00000440800 ENSP00000445191 ENSP00000441508 ENSP00000343787 ENSP00000439207

ENSP00000445310

Reactome Protein details: Q9UJX4
Human Recombinant Protein Products:

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	Uscn Proteins for ANAPC5

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	--
GO:0005654	nucleoplasm	TAS	--
GO:0005680	anaphase-promoting complex	IDA	16364912
GO:0005829	cytosol	TAS	--

ANAPC5 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ANAPC5 for domains About GeneDecksing

2 InterPro domains/families:

IPR011990 TPR-like_helical

IPR026000 Apc5_TPR

Graphical View of Domain Structure for InterPro Entry Q9UJX4

ProtoNet protein and cluster: Q9UJX4

UniProtKB/Swiss-Prot: APC5_HUMAN, Q9UJX4

Similarity: Belongs to the APC5 family

Similarity: Contains 4 TPR repeats

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: APC5_HUMAN, Q9UJX4

Function: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase

that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating

ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked

polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains

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In Situ Assay
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Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004842	ubiquitin-protein ligase activity	TAS	9469815
GO:0019903	protein phosphatase binding	IPI	--

ANAPC5 for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for ANAPC5:

Increased cell death HMECs cel

Increased cell death in breast

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/22 super-pathways (see all 22) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Ubiquitinated Orc1 is degraded by the proteasome

8/15 pathways (see all 15)
APC/C:Cdh1-mediated degradation of Skp2	0.74	APC/C:Cdc20 mediated degradation of mitotic proteins	0.69
APC/C:Cdc20 mediated degradation of Securin	0.74	APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	0.69
Degradation of multiubiquitinated Securin	0.74	Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	0.68
Autodegradation of Cdh1 by Cdh1:APC/C	0.70	Regulation of APC/C activators between G1/S and early anaphase	0.62

APC-Cdc20 mediated degradation of Nek2A

8/10 pathways (see all 10)
Degradation of multiubiquitinated Nek2A	1.00	Degradation of multiubiquitinated Cyclin B	0.76
APC-Cdc20 mediated degradation of Nek2A	1.00	Mitotic Spindle Checkpoint	0.75
Inactivation of APC/C via direct inhibition of the APC/C complex	0.78	Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	0.60
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	0.78	Phosphorylation of the APC/C	0.54

M Phase

M Phase	1.00	Mitotic Anaphase	0.85
Mitotic M-M/G1 phases	0.88	Separation of Sister Chromatids	0.80
Mitotic Metaphase and Anaphase	0.85

Antigen processing: Ubiquitination & Proteasome degradation

	Antigen processing: Ubiquitination & Proteasome degradation	1.00			Polyubiquitination of substrate	0.75
	Class I MHC mediated antigen processing & presentation	0.83			Ubiquitin mediated proteolysis	0.36

Cell cycle_Spindle assembly and chromosome separation

Cell cycle_Spindle assembly and chromosome separation

1.00

Cell cycle Spindle assembly and chromosome separation

0.94

Pathway sources
See GeneCards unified pathways
Show all pathways

5/9 EMD Millipore Pathways for ANAPC5 (see all 9)

	Cell cycle Role of APC in cell cycle regulation
	Meiosis
	Cell cycle Regulation of G1/S transition (part 1)
	Development TGF-beta receptor signaling
	Signal transduction PKA signaling

5/6 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for ANAPC5 (see all 6)

	Activation of PKA through GPCR
	Remodeling of Adherens Junctions
	cAMP Pathway
	CDC42 Pathway
	Mitotic Roles of Polo Like Kinases

5/7 GeneGo (Thomson Reuters) Pathways for ANAPC5 (see all 7)

	Cell cycle Role of APC in cell cycle regulation
	G-protein signaling G-Protein alpha-s signaling cascades
	Signal transduction PKA signaling
	Cell cycle Regulation of G1/S transition (part 1)
	Cell cycle Spindle assembly and chromosome separation

1 BioSystems Pathway for ANAPC5

TGF-beta Receptor Signaling Pathway

5/36 Reactome Pathways for ANAPC5 (see all 36)

	APC/C:Cdc20 mediated degradation of mitotic proteins
	Phosphorylation of the APC/C
	APC/C:Cdc20 mediated degradation of Securin
	Cdc20:Phospho-APC/C mediated degradation of Cyclin A
	Antigen processing: Ubiquitination & Proteasome degradation

4 Kegg Pathways (Kegg details for ANAPC5):

	Cell cycle
	Oocyte meiosis
	Ubiquitin mediated proteolysis
	Progesterone-mediated oocyte maturation

UniProtKB/Swiss-Prot: APC5_HUMAN, Q9UJX4

Pathway: Protein modification; protein ubiquitination

ANAPC5 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for ANAPC5

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/119 Interacting proteins for ANAPC5 (Q9UJX4^{2, 3} ENSP00000261819⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 119)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ZBTB16	Q05516²^,³, ENSP00000338157⁴	MINT-65751 I2D: score=5 STRING: ENSP00000338157
MAPK6	Q16659²^,³	MINT-8260669 I2D: score=2
PABPC1	P11940³, ENSP00000313007⁴	I2D: score=3 STRING: ENSP00000313007
ANAPC1	Q9H1A4³, ENSP00000339109⁴	I2D: score=2 STRING: ENSP00000339109
ANAPC7	Q9UJX3³, ENSP00000394394⁴	I2D: score=2 STRING: ENSP00000394394

About this table

Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000075	cell cycle checkpoint	TAS	--
GO:0000086	G2/M transition of mitotic cell cycle	TAS	9469815
GO:0000090	mitotic anaphase	TAS	9469815
GO:0000278	mitotic cell cycle	TAS	--
GO:0006511	ubiquitin-dependent protein catabolic process	TAS	9469815

ANAPC5 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ANAPC5
Search CenterWatch for drugs/clinical trials and news about ANAPC5 / APC5

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ANAPC5 gene (2 alternative transcripts):

NM_001137559.1 NM_016237.4

Unigene Cluster for ANAPC5:

Anaphase promoting complex subunit 5

Hs.7101 [show with all ESTs]

Unigene Representative Sequence: NM_016237

18/25 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 25):

ENST00000422342 ENST00000535641(uc001uae.3) ENST00000539079(uc001uaf.3)

ENST00000441917(uc001uah.3) ENST00000534976 ENST00000541887 ENST00000261819(uc010szv.2 uc001uag.3)

ENST00000535482(uc010szu.2) ENST00000543649 ENST00000545218 ENST00000366333

ENST00000535472 ENST00000538334 ENST00000535463 ENST00000538223 ENST00000539612

ENST00000541652 ENST00000544442

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Additional cDNA sequence:

AF191339.1 AK025614.1 AK054779.1 AK294139.1 AK301197.1 AK315451.1 BC001081.2 BC001950.1

BC003095.1 BC006301.2 BC034243.1 BX537687.1

24/35 DOTS entries (see all 35):

DT.100678453 DT.91776083 DT.447171 DT.100678448 DT.100678455 DT.95070195 DT.97860680 DT.95070179

DT.121164737 DT.100638763 DT.40223869 DT.121164919 DT.40107121 DT.100678457 DT.91872681 DT.91951806

DT.91962906 DT.100733870 DT.91776084 DT.92340179 DT.100039495 DT.100678445 DT.100678450 DT.121164723

24/744 AceView cDNA sequences (see all 744):

CA434955 AW008017 BE266135 AA344166 BM717017 CA307540 BQ690984 BM968649

BC006301 Z41497 BG284735 BQ063931 AI065074 AV654917 AA991308 BU682708

CA388898 BM986791 AA976395 BM996406 AF191339 AA985638 BM713099 BQ055744

GeneLoc Exon Structure

5/20 Alternative Splicing Database (ASD) splice patterns (SP) for ANAPC5 (see all 20) About this scheme

ExUns:	1	^	2a	·	2b	·	2c	·	2d	·	2e	·	2f	^	3	^	4a	·	4b	^	5a	·	5b	^	6	^	7a	·	7b	^	8a	·	8b	^	9	^	10a	·	10b	·	10c	^	11a	·	11b	·	11c	^	12a	·	12b	·
SP1:			-		-		-		-		-		-		-				-				-		-		-		-
SP2:															-				-				-		-		-		-
SP3:																																																	-		-
SP4:
SP5:

ExUns:	12c	^	13a	·	13b	·	13c	·	13d	^	14a	·	14b	·	14c	·	14d	·	14e	·	14f	^	15a	·	15b	·	15c	·	15d	^	16	^	17	^	18a	·	18b	^	19	^	20	^	21a	·	21b	^	22	^	23a	·	23b	·
SP1:	-		-		-						-		-				-		-		-		-		-						-												-		-
SP2:	-		-		-												-		-		-		-		-						-												-		-
SP3:	-		-		-		-		-								-		-		-		-		-						-												-
SP4:																															-												-		-
SP5:	-		-		-						-

ECgene alternative splicing isoforms for ANAPC5

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ANAPC5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCCCCTCTCT

About this image
See ANAPC5 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ANAPC5

SOURCE GeneReport for Unigene cluster: Hs.7101

SABiosciences Expression via Pathway-Focused PCR Array including ANAPC5:

Ubiquitin Ligases in human mouse rat

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for ANAPC5 gene from 8/22 species (see all 22) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Anapc5^{1 , 5}	anaphase-promoting complex subunit 5^{1, 5}	90.05(n)¹ 94.73(a)¹		5 (62.58 cM)⁵ 59008¹ NM_021505.2¹ NP_067480.2¹ 122787469⁵
chicken (Gallus gallus)	Aves	ANAPC5¹	anaphase promoting complex subunit 5	78.5(n) 85.77(a)		416842 NM_001006187.1 NP_001006187.1
lizard (Anolis carolinensis)	Reptilia	-- -- (see all 3)	--	77(a) 76(a) (see all 3)	possible ortholog possible ortholog (see all 3)	AAWZ02041481(1950-4965) GL345060.1(1814-11188)
tropical clawed frog (Xenopus tropicalis)	Amphibia	Str.11772²	Transcribed sequence with weak similarity to protein more	79.1(n)		BX719854.1
zebrafish (Danio rerio)	Actinopterygii	wufb75a09²	wufb75a09	75.71(n)		322854 BC045458.1
fruit fly (Drosophila melanogaster)	Insecta	ida¹	imaginal discs arrested	40.46(n) 27.46(a)		45574 NM_139580.2 NP_647837.2
thale cress (Arabidopsis thaliana)	eudicotyledons	AT1G06590¹	anaphase-promoting complex subunit 5	41.72(n) 29.97(a)		837170 NM_100538.4 NP_172146.2
rice (Oryza sativa)	Liliopsida	--	expressed protein	19(a)	1 ↔ 1	12(26737124-26745515)

ENSEMBL Gene Tree for ANAPC5 (if available)
TreeFam Gene Tree for ANAPC5 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 12 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs146732546^1,2		--	121745551(+)	`CTGCTA/GGGATT`	2	--	ds500¹		0	--	--	--	--
rs183720546^1,2		--	121745625(+)	`TGGACA/GTAATT`	2	--	ds500¹		0	--	--	--	--
rs2686357^1,2	C	--	121745742(+)	`ATTGGT/GCCAAA`	2	--	ds500¹		2		NA	4
rs140315759^1,2		--	121745794(+)	`ACCAAC/TAAGTC`	2	--	ds500¹		0	--	--	--	--
rs188191540^1,2		--	121745802(+)	`GTCCTC/TGTGAG`	2	--	ds500¹		0	--	--	--	--
rs145354580^1,2		--	121745816(+)	`CCACAG/TGAACC`	2	--	ds500¹		0	--	--	--	--
rs74820648^1,2	F,	--	121745828(+)	`CAAGCG/ACTGGT`	2	--	ds500¹		1		EA	120
rs111940471^1,2	F,	--	121745837(+)	`GTTCAG/CTCCAA`	2	--	ds500¹		2		CSA	4
rs192958876^1,2		--	121745941(+)	`TCTGAA/GAATAG`	2	--	ds500¹		0	--	--	--	--
rs117562882^1,2	C,F,	--	121745975(+)	`ATGGAG/TTGTGT`	2	--	ds500¹		1		NA	120

HapMap Linkage Disequilibrium report for ANAPC5 (121746048 - 121837699 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ANAPC5: --

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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ANAPC5 for disorders           About GeneDecksing

OMIM gene information: 606948    OMIM disorders: --

2 diseases for ANAPC5:    About MalaCards

cytomegalovirus infection neuronitis

Export disorders for ANAPC5 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for ANAPC5 gene, integrated from 9 sources (see all 60):
(articles sorted by number of sources associating them with ANAPC5)

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world of online information

Identification of a cullin homology region in a subunit of the anaphase-promoting complex. (PubMed id 9469815)^{1, 2, 3, 9} Yu H.... Kirschner M.W. (1998)
Mechanism of ubiquitin-chain formation by the human anaphase-promoting complex. (PubMed id 18485873)^{1, 2} Jin L....Rape M. (2008)
Localization of the coactivator Cdh1 and the cullin subunit Apc2 in a cryo-electron microscopy model of vertebrate APC/C. (PubMed id 16364912)^{1, 2} Dube P.... Stark H. (2005)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Mitotic regulation of the human anaphase-promoting complex by phosphorylation. (PubMed id 14657031)^{1, 2} Kraft C....Peters J.-M. (2003)
Expression of anaphase-promoting complex 5 in balloon angioplasty-injured rat carotid arteries and mitogen-stimulated human vascular smooth muscle cells. (PubMed id 11401522)^{1, 9} Autieri M.V. (2001)
Regulation of E2F1 by APC/C Cdh1 via K11 linkage-speci fic ubiquitin chain formation. (PubMed id 22580462)¹ Budhavarapu V.N....Lin W.C. (2012)
A census of human soluble protein complexes. (PubMed id 22939629)¹ Havugimana P.C....Emili A. (2012)
Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)¹ Woods N.T....Monteiro A.N. (2012)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 51433	HGNC: 15713	AceView: ANAPC5	Ensembl:ENSG00000089053	euGenes: HUgn51433
ECgene: ANAPC5	Kegg: 51433	H-InvDB: ANAPC5

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ANAPC5	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ANAPC5 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for ANAPC5 gene:
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GeneCards and IP:
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anaphase promoting complex subunit 5

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ANAPC5 Gene

anaphase promoting complex subunit 5

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