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Aliases for ANAPC5 Gene

Aliases for ANAPC5 Gene

  • Anaphase Promoting Complex Subunit 5 2 3 5
  • Cyclosome Subunit 5 3 4
  • APC5 3 4
  • Anaphase-Promoting Complex Subunit 5 3

External Ids for ANAPC5 Gene

Previous GeneCards Identifiers for ANAPC5 Gene

  • GC12M120611
  • GC12M121529
  • GC12M120158
  • GC12M120208
  • GC12M121746
  • GC12M118756

Summaries for ANAPC5 Gene

Entrez Gene Summary for ANAPC5 Gene

  • This gene encodes a tetratricopeptide repeat-containing component of the anaphase promoting complex/cyclosome (APC/C), a large E3 ubiquitin ligase that controls cell cycle progression by targeting a number of cell cycle regulators such as B-type cyclins for 26S proteasome-mediated degradation through ubiquitination. The encoded protein is required for the proper ubiquitination function of APC/C and for the interaction of APC/C with transcription coactivators. It also interacts with polyA binding protein and represses internal ribosome entry site-mediated translation. Multiple transcript variants encoding different isoforms have been found for this gene. These differences cause translation initiation at a downstream AUG and result in a shorter protein (isoform b), compared to isoform a. [provided by RefSeq, Nov 2008]

GeneCards Summary for ANAPC5 Gene

ANAPC5 (Anaphase Promoting Complex Subunit 5) is a Protein Coding gene. Among its related pathways are G-protein signaling G-Protein alpha-i signaling cascades and APC-Cdc20 mediated degradation of Nek2A. GO annotations related to this gene include protein phosphatase binding.

UniProtKB/Swiss-Prot for ANAPC5 Gene

  • Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of Lys-11-linked polyubiquitin chains and, to a lower extent, the formation of Lys-48- and Lys-63-linked polyubiquitin chains.

Gene Wiki entry for ANAPC5 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANAPC5 Gene

Genomics for ANAPC5 Gene

Regulatory Elements for ANAPC5 Gene

Enhancers for ANAPC5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12G121351 1.2 ENCODE 39.4 +47.5 47512 2.7 MLX CREB3L1 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC TBX21 MEF2D ANAPC5 CAMKK2 PSMD9 RNF34 SRSF9 SETD1B ENSG00000272849 ENSG00000258435
GH12G121655 1 dbSUPER 42.1 -257.0 -257000 1.8 HDGF ARNT ZNF493 GLI4 YBX1 ZNF2 ZNF302 CBX5 KLF7 ZNF548 ZCCHC8 SETD1B ANAPC5 ENSG00000272849 KNTC1 LINC01089 PSMD9 LOC101928346 TMEM120B UNC119B
GH12G120528 1.2 ENCODE 32.6 +870.5 870452 2.4 CREB3L1 ZFP64 FEZF1 DMAP1 YY1 ZNF143 SP3 MEF2D ZNF610 GLIS1 COQ5 GCN1 ANAPC5 RPL31P52 GATC PRKAB1 C12orf43 RNF10 RPL29P24
GH12G122061 1.7 Ensembl ENCODE dbSUPER 20.2 -663.6 -663571 4.6 CREB3L1 AGO1 DMAP1 FEZF1 YY1 SLC30A9 ZNF143 SP3 NFYC TBX21 ZCCHC8 PSMD9 KNTC1 SETD1B ANAPC5 LOC100506691 BCL7A ENSG00000255856 HPD ENSG00000256950
GH12G120683 1.4 ENCODE dbSUPER 23.6 +712.4 712449 7.3 CREB3L1 ZFP64 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 SP3 NFYC GCN1 ACADS ANAPC5 C12orf43 MLEC ENSG00000256569 RPL31P52 ENSG00000255946 UNC119B COQ5
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ANAPC5 on UCSC Golden Path with GeneCards custom track

Promoters for ANAPC5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000058439 -204 2201 HDGF PKNOX1 CREB3L1 ARNT AGO1 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B

Genomic Location for ANAPC5 Gene

Chromosome:
12
Start:
121,308,245 bp from pter
End:
121,399,896 bp from pter
Size:
91,652 bases
Orientation:
Minus strand

Genomic View for ANAPC5 Gene

Genes around ANAPC5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANAPC5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANAPC5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANAPC5 Gene

Proteins for ANAPC5 Gene

  • Protein details for ANAPC5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UJX4-APC5_HUMAN
    Recommended name:
    Anaphase-promoting complex subunit 5
    Protein Accession:
    Q9UJX4
    Secondary Accessions:
    • E9PFB2
    • Q8N4H7
    • Q9BQD4

    Protein attributes for ANAPC5 Gene

    Size:
    755 amino acids
    Molecular mass:
    85077 Da
    Quaternary structure:
    • The mammalian APC/C is composed of 14 distinct subunits that assemble into a complex of at least 19 chains with a combined molecular mass of around 1.2 MDa.

    Three dimensional structures from OCA and Proteopedia for ANAPC5 Gene

    Alternative splice isoforms for ANAPC5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ANAPC5 Gene

Post-translational modifications for ANAPC5 Gene

  • Ubiquitination at Lys224, Lys229, posLast=238238, Lys289, posLast=403403, and Lys669
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ANAPC5 Gene

Domains & Families for ANAPC5 Gene

Gene Families for ANAPC5 Gene

Protein Domains for ANAPC5 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UJX4

UniProtKB/Swiss-Prot:

APC5_HUMAN :
  • The TPR repeats are six to seven residues longer than a canonical TPR motif.
  • Belongs to the APC5 family.
Domain:
  • The TPR repeats are six to seven residues longer than a canonical TPR motif.
Family:
  • Belongs to the APC5 family.
genes like me logo Genes that share domains with ANAPC5: view

Function for ANAPC5 Gene

Molecular function for ANAPC5 Gene

UniProtKB/Swiss-Prot Function:
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of Lys-11-linked polyubiquitin chains and, to a lower extent, the formation of Lys-48- and Lys-63-linked polyubiquitin chains.

Gene Ontology (GO) - Molecular Function for ANAPC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019903 protein phosphatase binding IPI 21241890
genes like me logo Genes that share ontologies with ANAPC5: view
genes like me logo Genes that share phenotypes with ANAPC5: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ANAPC5 Gene

Localization for ANAPC5 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ANAPC5 gene
Compartment Confidence
nucleus 5
cytosol 5
mitochondrion 1
peroxisome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for ANAPC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21241890
GO:0005654 nucleoplasm TAS --
GO:0005680 anaphase-promoting complex IDA 16364912
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with ANAPC5: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ANAPC5 Gene

Pathways & Interactions for ANAPC5 Gene

SuperPathways for ANAPC5 Gene

SuperPathway Contained pathways
1 CDK-mediated phosphorylation and removal of Cdc6
2 APC-Cdc20 mediated degradation of Nek2A
3 Class I MHC mediated antigen processing and presentation
4 Cell Cycle, Mitotic
.60
5 Cellular Senescence
genes like me logo Genes that share pathways with ANAPC5: view

UniProtKB/Swiss-Prot Q9UJX4-APC5_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for ANAPC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007049 cell cycle IEA --
GO:0007067 mitotic nuclear division IEA --
GO:0016567 protein ubiquitination IEA --
GO:0031145 anaphase-promoting complex-dependent catabolic process TAS --
GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process TAS --
genes like me logo Genes that share ontologies with ANAPC5: view

No data available for SIGNOR curated interactions for ANAPC5 Gene

Drugs & Compounds for ANAPC5 Gene

(1) Drugs for ANAPC5 Gene - From: ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
TAME Pharma 0

(1) ApexBio Compounds for ANAPC5 Gene

Compound Action Cas Number
TAME 901-47-3
genes like me logo Genes that share compounds with ANAPC5: view

Drug Products

Transcripts for ANAPC5 Gene

Unigene Clusters for ANAPC5 Gene

Anaphase promoting complex subunit 5:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ANAPC5 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e · 2f ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b · 11c ^ 12a · 12b ·
SP1: - - - - - - - - - - - -
SP2: - - - - - -
SP3: - -
SP4:
SP5:
SP6: -
SP7:
SP8: - -
SP9:
SP10:
SP11: - - - - -
SP12: -
SP13: - - - - - - -
SP14: - -
SP15: - -
SP16:
SP17:
SP18: - - - - - - - -
SP19: -
SP20:

ExUns: 12c ^ 13a · 13b · 13c · 13d ^ 14a · 14b · 14c · 14d · 14e · 14f ^ 15a · 15b · 15c · 15d ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21a · 21b ^ 22 ^ 23a · 23b ·
SP1: - - - - - - - - - - - - -
SP2: - - - - - - - - - - -
SP3: - - - - - - - - - - - -
SP4: - - -
SP5: - - - -
SP6: - - - - - - - - - - - - - - -
SP7: - -
SP8: - - - - - - - - -
SP9: - - -
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17: - -
SP18:
SP19:
SP20:

Relevant External Links for ANAPC5 Gene

GeneLoc Exon Structure for
ANAPC5
ECgene alternative splicing isoforms for
ANAPC5

Expression for ANAPC5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ANAPC5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ANAPC5 Gene

This gene is overexpressed in Breast (17.2), Plasma (14.0), Bone (8.3), and Pancreas (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ANAPC5 Gene



Protein tissue co-expression partners for ANAPC5 Gene

NURSA nuclear receptor signaling pathways regulating expression of ANAPC5 Gene:

ANAPC5

SOURCE GeneReport for Unigene cluster for ANAPC5 Gene:

Hs.7101

Evidence on tissue expression from TISSUES for ANAPC5 Gene

  • Nervous system(4.9)
  • Lung(4.8)
  • Eye(3)
  • Intestine(2.9)
  • Skin(2.9)
genes like me logo Genes that share expression patterns with ANAPC5: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ANAPC5 Gene

Orthologs for ANAPC5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ANAPC5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ANAPC5 34 35
  • 99.78 (n)
dog
(Canis familiaris)
Mammalia ANAPC5 34 35
  • 92.89 (n)
cow
(Bos Taurus)
Mammalia ANAPC5 34 35
  • 92.05 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 91 (a)
OneToMany
-- 35
  • 82 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Anapc5 34 16 35
  • 90.05 (n)
oppossum
(Monodelphis domestica)
Mammalia ANAPC5 35
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Anapc5 34
  • 89.04 (n)
chicken
(Gallus gallus)
Aves ANAPC5 34 35
  • 78.46 (n)
lizard
(Anolis carolinensis)
Reptilia ANAPC5 35
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia anapc5 34
  • 75.64 (n)
Str.11772 34
zebrafish
(Danio rerio)
Actinopterygii anapc5 34 35
  • 65.65 (n)
wufb75a09 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4568 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005578 34
  • 44.2 (n)
fruit fly
(Drosophila melanogaster)
Insecta ida 34 35
  • 40.67 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G06590 34
  • 42.53 (n)
Species where no ortholog for ANAPC5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ANAPC5 Gene

ENSEMBL:
Gene Tree for ANAPC5 (if available)
TreeFam:
Gene Tree for ANAPC5 (if available)

Paralogs for ANAPC5 Gene

No data available for Paralogs for ANAPC5 Gene

Variants for ANAPC5 Gene

Sequence variations from dbSNP and Humsavar for ANAPC5 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
VAR_035793 A breast cancer sample
rs1000019377 -- 121,317,517(+) AAAGT(A/G)CTGGG intron-variant
rs1000152768 -- 121,333,128(+) CTGAC(C/T)GATAT intron-variant
rs1000231546 -- 121,314,286(+) CCCAG(A/C)TACTT intron-variant
rs1000353813 -- 121,308,173(+) TGGAG(C/T)GTGTA downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for ANAPC5 Gene

Variant ID Type Subtype PubMed ID
esv3630946 CNV loss 21293372
nsv1048801 CNV gain 25217958
nsv1054878 CNV gain 25217958
nsv521928 CNV gain 19592680
nsv560455 CNV gain 21841781

Variation tolerance for ANAPC5 Gene

Residual Variation Intolerance Score: 13.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.83; 34.39% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ANAPC5 Gene

Human Gene Mutation Database (HGMD)
ANAPC5
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ANAPC5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANAPC5 Gene

Disorders for ANAPC5 Gene

Relevant External Links for ANAPC5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ANAPC5

No disorders were found for ANAPC5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANAPC5 Gene

Publications for ANAPC5 Gene

  1. Identification of a cullin homology region in a subunit of the anaphase-promoting complex. (PMID: 9469815) Yu H. … Kirschner M.W. (Science 1998) 2 3 4 22 64
  2. Molecular architecture and mechanism of the anaphase-promoting complex. (PMID: 25043029) Chang L. … Barford D. (Nature 2014) 3 4 64
  3. Mechanism of ubiquitin-chain formation by the human anaphase- promoting complex. (PMID: 18485873) Jin L. … Rape M. (Cell 2008) 3 4 64
  4. Localization of the coactivator Cdh1 and the cullin subunit Apc2 in a cryo-electron microscopy model of vertebrate APC/C. (PMID: 16364912) Dube P. … Stark H. (Mol. Cell 2005) 3 4 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64

Products for ANAPC5 Gene

Sources for ANAPC5 Gene

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