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Aliases for ANAPC5 Gene

Aliases for ANAPC5 Gene

  • Anaphase Promoting Complex Subunit 5 2 3
  • Cyclosome Subunit 5 3 4
  • APC5 3 4

External Ids for ANAPC5 Gene

Previous GeneCards Identifiers for ANAPC5 Gene

  • GC12M120611
  • GC12M121529
  • GC12M120158
  • GC12M120208
  • GC12M121746
  • GC12M118756

Summaries for ANAPC5 Gene

Entrez Gene Summary for ANAPC5 Gene

  • This gene encodes a tetratricopeptide repeat-containing component of the anaphase promoting complex/cyclosome (APC/C), a large E3 ubiquitin ligase that controls cell cycle progression by targeting a number of cell cycle regulators such as B-type cyclins for 26S proteasome-mediated degradation through ubiquitination. The encoded protein is required for the proper ubiquitination function of APC/C and for the interaction of APC/C with transcription coactivators. It also interacts with polyA binding protein and represses internal ribosome entry site-mediated translation. Multiple transcript variants encoding different isoforms have been found for this gene. These differences cause translation initiation at a downstream AUG and result in a shorter protein (isoform b), compared to isoform a. [provided by RefSeq, Nov 2008]

GeneCards Summary for ANAPC5 Gene

ANAPC5 (Anaphase Promoting Complex Subunit 5) is a Protein Coding gene. Among its related pathways are Immune System and Activation of cAMP-Dependent PKA. GO annotations related to this gene include protein phosphatase binding.

UniProtKB/Swiss-Prot for ANAPC5 Gene

  • Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of Lys-11-linked polyubiquitin chains and, to a lower extent, the formation of Lys-48- and Lys-63-linked polyubiquitin chains.

Gene Wiki entry for ANAPC5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANAPC5 Gene

Genomics for ANAPC5 Gene

Regulatory Elements for ANAPC5 Gene

Genomic Location for ANAPC5 Gene

Chromosome:
12
Start:
121,308,245 bp from pter
End:
121,399,896 bp from pter
Size:
91,652 bases
Orientation:
Minus strand

Genomic View for ANAPC5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ANAPC5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANAPC5 Gene

Proteins for ANAPC5 Gene

  • Protein details for ANAPC5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UJX4-APC5_HUMAN
    Recommended name:
    Anaphase-promoting complex subunit 5
    Protein Accession:
    Q9UJX4
    Secondary Accessions:
    • E9PFB2
    • Q8N4H7
    • Q9BQD4

    Protein attributes for ANAPC5 Gene

    Size:
    755 amino acids
    Molecular mass:
    85077 Da
    Quaternary structure:
    • The mammalian APC/C is composed of 14 distinct subunits that assemble into a complex of at least 19 chains with a combined molecular mass of around 1.2 MDa.

    Three dimensional structures from OCA and Proteopedia for ANAPC5 Gene

    Alternative splice isoforms for ANAPC5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ANAPC5 Gene

Proteomics data for ANAPC5 Gene at MOPED

Post-translational modifications for ANAPC5 Gene

  • Ubiquitination at Lys 224, Lys 229, Lys 238, Lys 289, Lys 403, and Lys 669
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for ANAPC5 Gene

Domains & Families for ANAPC5 Gene

Gene Families for ANAPC5 Gene

Protein Domains for ANAPC5 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9UJX4

UniProtKB/Swiss-Prot:

APC5_HUMAN :
  • The TPR repeats are six to seven residues longer than a canonical TPR motif.
  • Belongs to the APC5 family.
  • Contains 13 TPR repeats.
Domain:
  • The TPR repeats are six to seven residues longer than a canonical TPR motif.
Family:
  • Belongs to the APC5 family.
Similarity:
  • Contains 13 TPR repeats.
genes like me logo Genes that share domains with ANAPC5: view

Function for ANAPC5 Gene

Molecular function for ANAPC5 Gene

UniProtKB/Swiss-Prot Function:
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of Lys-11-linked polyubiquitin chains and, to a lower extent, the formation of Lys-48- and Lys-63-linked polyubiquitin chains.

Gene Ontology (GO) - Molecular Function for ANAPC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0019903 protein phosphatase binding IPI 21241890
genes like me logo Genes that share ontologies with ANAPC5: view
genes like me logo Genes that share phenotypes with ANAPC5: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ANAPC5

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for ANAPC5 Gene

Localization for ANAPC5 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ANAPC5 Gene COMPARTMENTS Subcellular localization image for ANAPC5 gene
Compartment Confidence
nucleus 5
cytosol 4

Gene Ontology (GO) - Cellular Components for ANAPC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21241890
GO:0005654 nucleoplasm TAS --
GO:0005680 anaphase-promoting complex IDA 16364912
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with ANAPC5: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ANAPC5 Gene

Pathways & Interactions for ANAPC5 Gene

SuperPathways for ANAPC5 Gene

Superpath Contained pathways
1 CDK-mediated phosphorylation and removal of Cdc6
2 Separation of Sister Chromatids
3 APC-Cdc20 mediated degradation of Nek2A
4 Cell Cycle, Mitotic
.62
5 Cellular Senescence
genes like me logo Genes that share pathways with ANAPC5: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

UniProtKB/Swiss-Prot Q9UJX4-APC5_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for ANAPC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle TAS --
GO:0007067 mitotic nuclear division IEA --
GO:0007094 mitotic spindle assembly checkpoint TAS --
GO:0031145 anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process TAS --
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with ANAPC5: view

No data available for SIGNOR curated interactions for ANAPC5 Gene

Drugs & Compounds for ANAPC5 Gene

(1) Drugs for ANAPC5 Gene - From: ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
TAME Pharma 0
genes like me logo Genes that share compounds with ANAPC5: view

Transcripts for ANAPC5 Gene

Unigene Clusters for ANAPC5 Gene

Anaphase promoting complex subunit 5:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ANAPC5

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ANAPC5 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e · 2f ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b · 11c ^ 12a · 12b ·
SP1: - - - - - - - - - - - -
SP2: - - - - - -
SP3: - -
SP4:
SP5:
SP6: -
SP7:
SP8: - -
SP9:
SP10:
SP11: - - - - -
SP12: -
SP13: - - - - - - -
SP14: - -
SP15: - -
SP16:
SP17:
SP18: - - - - - - - -
SP19: -
SP20:

ExUns: 12c ^ 13a · 13b · 13c · 13d ^ 14a · 14b · 14c · 14d · 14e · 14f ^ 15a · 15b · 15c · 15d ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21a · 21b ^ 22 ^ 23a · 23b ·
SP1: - - - - - - - - - - - - -
SP2: - - - - - - - - - - -
SP3: - - - - - - - - - - - -
SP4: - - -
SP5: - - - -
SP6: - - - - - - - - - - - - - - -
SP7: - -
SP8: - - - - - - - - -
SP9: - - -
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17: - -
SP18:
SP19:
SP20:

Relevant External Links for ANAPC5 Gene

GeneLoc Exon Structure for
ANAPC5
ECgene alternative splicing isoforms for
ANAPC5

Expression for ANAPC5 Gene

mRNA expression in normal human tissues for ANAPC5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ANAPC5 Gene

This gene is overexpressed in Breast (17.2), Plasma (14.0), Bone (8.3), and Pancreas (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ANAPC5 Gene



SOURCE GeneReport for Unigene cluster for ANAPC5 Gene Hs.7101

genes like me logo Genes that share expression patterns with ANAPC5: view

Protein tissue co-expression partners for ANAPC5 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ANAPC5 Gene

Orthologs for ANAPC5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ANAPC5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ANAPC5 35
  • 92.05 (n)
  • 97.22 (a)
ANAPC5 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ANAPC5 35
  • 92.89 (n)
  • 97.88 (a)
ANAPC5 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Anapc5 35
  • 90.05 (n)
  • 94.73 (a)
Anapc5 16
Anapc5 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ANAPC5 35
  • 99.78 (n)
  • 100 (a)
ANAPC5 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Anapc5 35
  • 89.04 (n)
  • 95.05 (a)
oppossum
(Monodelphis domestica)
Mammalia ANAPC5 36
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 82 (a)
OneToMany
-- 36
  • 91 (a)
OneToMany
chicken
(Gallus gallus)
Aves ANAPC5 35
  • 78.46 (n)
  • 85.77 (a)
ANAPC5 36
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ANAPC5 36
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia anapc5 35
  • 75.64 (n)
  • 82.4 (a)
Str.11772 35
zebrafish
(Danio rerio)
Actinopterygii anapc5 35
  • 65.65 (n)
  • 66.84 (a)
wufb75a09 35
anapc5 36
  • 65 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4568 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005578 35
  • 44.2 (n)
  • 31.86 (a)
fruit fly
(Drosophila melanogaster)
Insecta ida 35
  • 40.67 (n)
  • 28.07 (a)
ida 36
  • 23 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G06590 35
  • 42.53 (n)
  • 31.17 (a)
Species with no ortholog for ANAPC5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ANAPC5 Gene

ENSEMBL:
Gene Tree for ANAPC5 (if available)
TreeFam:
Gene Tree for ANAPC5 (if available)

Paralogs for ANAPC5 Gene

No data available for Paralogs for ANAPC5 Gene

Variants for ANAPC5 Gene

Sequence variations from dbSNP and Humsavar for ANAPC5 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs190795625 -- 121,316,447(+) AGGTA(C/T)TCAAC intron-variant
rs191042943 -- 121,320,391(+) TGGGC(A/C/G)TGCTG reference, missense, synonymous-codon
rs191199094 -- 121,320,868(+) AAAGT(A/G)CTGGA intron-variant
rs191205473 -- 121,323,575(+) GATAC(A/G)CCTGC intron-variant
rs191640033 -- 121,313,070(+) CCTGT(A/G)ATCCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ANAPC5 Gene

Variant ID Type Subtype PubMed ID
nsv521928 CNV Gain 19592680

Variation tolerance for ANAPC5 Gene

Residual Variation Intolerance Score: 13.27% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.83; 34.39% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ANAPC5 Gene

HapMap Linkage Disequilibrium report
ANAPC5
Human Gene Mutation Database (HGMD)
ANAPC5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANAPC5 Gene

Disorders for ANAPC5 Gene

Relevant External Links for ANAPC5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ANAPC5
genes like me logo Genes that share disorders with ANAPC5: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANAPC5 Gene

Publications for ANAPC5 Gene

  1. Identification of a cullin homology region in a subunit of the anaphase-promoting complex. (PMID: 9469815) Yu H. … Kirschner M.W. (Science 1998) 2 23 67
  2. Expression of anaphase-promoting complex 5 in balloon angioplasty-injured rat carotid arteries and mitogen-stimulated human vascular smooth muscle cells. (PMID: 11401522) Autieri M.V. (Biochem. Biophys. Res. Commun. 2001) 23 67
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  4. Structure of an APC3-APC16 complex: insights into assembly of the anaphase-promoting complex/cyclosome. (PMID: 25490258) Yamaguchi M. … Schulman B.A. (J. Mol. Biol. 2015) 67
  5. Atomic structure of the APC/C and its mechanism of protein ubiquitination. (PMID: 26083744) Chang L. … Barford D. (Nature 2015) 67

Products for ANAPC5 Gene

Sources for ANAPC5 Gene

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