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Aliases for ANAPC4 Gene

Aliases for ANAPC4 Gene

  • Anaphase Promoting Complex Subunit 4 2 3
  • APC4 3 4 6
  • Cyclosome Subunit 4 3 4
  • Anaphase-Promoting Complex Subunit 4 3

External Ids for ANAPC4 Gene

Summaries for ANAPC4 Gene

Entrez Gene Summary for ANAPC4 Gene

  • A large protein complex, termed the anaphase-promoting complex (APC), or the cyclosome, promotes metaphase-anaphase transition by ubiquitinating its specific substrates such as mitotic cyclins and anaphase inhibitor, which are subsequently degraded by the 26S proteasome. Biochemical studies have shown that the vertebrate APC contains eight subunits. The composition of the APC is highly conserved in organisms from yeast to humans. The exact function of this gene product is not known. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]

GeneCards Summary for ANAPC4 Gene

ANAPC4 (Anaphase Promoting Complex Subunit 4) is a Protein Coding gene. Among its related pathways are Class I MHC mediated antigen processing and presentation and PAK Pathway. GO annotations related to this gene include ubiquitin-protein transferase activity and protein phosphatase binding.

UniProtKB/Swiss-Prot for ANAPC4 Gene

  • Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of Lys-11-linked polyubiquitin chains and, to a lower extent, the formation of Lys-48- and Lys-63-linked polyubiquitin chains.

Gene Wiki entry for ANAPC4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANAPC4 Gene

Genomics for ANAPC4 Gene

Genomic Location for ANAPC4 Gene

Start:
25,377,213 bp from pter
End:
25,418,498 bp from pter
Size:
41,286 bases
Orientation:
Plus strand

Genomic View for ANAPC4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ANAPC4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANAPC4 Gene

Regulatory Elements for ANAPC4 Gene

Proteins for ANAPC4 Gene

  • Protein details for ANAPC4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UJX5-APC4_HUMAN
    Recommended name:
    Anaphase-promoting complex subunit 4
    Protein Accession:
    Q9UJX5
    Secondary Accessions:
    • A8K8H1
    • E9PCR4
    • Q6PCC6
    • Q9NSH6

    Protein attributes for ANAPC4 Gene

    Size:
    808 amino acids
    Molecular mass:
    92116 Da
    Quaternary structure:
    • The mammalian APC/C is composed of 14 distinct subunits that assemble into a complex of at least 19 chains with a combined molecular mass of around 1.2 MDa.

    Alternative splice isoforms for ANAPC4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ANAPC4 Gene

Proteomics data for ANAPC4 Gene at MOPED

Post-translational modifications for ANAPC4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ANAPC4 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for ANAPC4 Gene

Domains for ANAPC4 Gene

Gene Families for ANAPC4 Gene

HGNC:
  • ANAPC :Anaphase promoting complex subunits

Protein Domains for ANAPC4 Gene

UniProtKB/Swiss-Prot:

APC4_HUMAN
Family:
  • Belongs to the APC4 family.:
    • Q9UJX5
genes like me logo Genes that share domains with ANAPC4: view

Function for ANAPC4 Gene

Molecular function for ANAPC4 Gene

UniProtKB/Swiss-Prot Function: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of Lys-11-linked polyubiquitin chains and, to a lower extent, the formation of Lys-48- and Lys-63-linked polyubiquitin chains.

Gene Ontology (GO) - Molecular Function for ANAPC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity TAS 6180011
GO:0005515 protein binding IPI 23288039
GO:0019903 protein phosphatase binding IPI 21241890
genes like me logo Genes that share ontologies with ANAPC4: view
genes like me logo Genes that share phenotypes with ANAPC4: view

miRNA for ANAPC4 Gene

miRTarBase miRNAs that target ANAPC4

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ANAPC4 Gene

Localization for ANAPC4 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ANAPC4 Gene COMPARTMENTS Subcellular localization image for ANAPC4 gene
Compartment Confidence
nucleus 5
cytosol 4
cytoskeleton 2
mitochondrion 2
golgi apparatus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for ANAPC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21241890
GO:0005654 nucleoplasm TAS --
GO:0005680 anaphase-promoting complex IDA 16364912
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with ANAPC4: view

Pathways for ANAPC4 Gene

SuperPathways for ANAPC4 Gene

genes like me logo Genes that share pathways with ANAPC4: view

UniProtKB/Swiss-Prot Q9UJX5-APC4_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for ANAPC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle TAS --
GO:0007067 mitotic nuclear division IEA --
GO:0007094 mitotic spindle assembly checkpoint TAS --
GO:0030071 regulation of mitotic metaphase/anaphase transition --
GO:0031145 anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process TAS --
genes like me logo Genes that share ontologies with ANAPC4: view

Transcripts for ANAPC4 Gene

Unigene Clusters for ANAPC4 Gene

Anaphase promoting complex subunit 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ANAPC4 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b · 14c ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^
SP1: - -
SP2: - -
SP3: -
SP4: -
SP5:
SP6: -
SP7:
SP8:
SP9: -
SP10:

ExUns: 20 ^ 21a · 21b ^ 22a · 22b ^ 23a · 23b ^ 24 ^ 25 ^ 26a · 26b ^ 27 ^ 28 ^ 29a · 29b · 29c
SP1: - - -
SP2: - - -
SP3:
SP4:
SP5:
SP6:
SP7: -
SP8:
SP9:
SP10:

Relevant External Links for ANAPC4 Gene

GeneLoc Exon Structure for
ANAPC4
ECgene alternative splicing isoforms for
ANAPC4

Expression for ANAPC4 Gene

mRNA expression in normal human tissues for ANAPC4 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ANAPC4 Gene

SOURCE GeneReport for Unigene cluster for ANAPC4 Gene Hs.152173

genes like me logo Genes that share expressions with ANAPC4: view

Orthologs for ANAPC4 Gene

This gene was present in the common ancestor of animals.

Orthologs for ANAPC4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ANAPC4 36
  • 99.83 (n)
  • 99.88 (a)
ANAPC4 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ANAPC4 36
  • 93.23 (n)
  • 97.15 (a)
ANAPC4 37
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ANAPC4 36
  • 92.99 (n)
  • 97.52 (a)
ANAPC4 37
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Anapc4 36
  • 87.77 (n)
  • 93.56 (a)
Anapc4 16
Anapc4 37
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ANAPC4 37
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 76 (a)
OneToMany
-- 37
  • 46 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Anapc4 36
  • 87.81 (n)
  • 93.8 (a)
chicken
(Gallus gallus)
Aves ANAPC4 36
  • 77.97 (n)
  • 78.64 (a)
ANAPC4 37
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ANAPC4 37
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia anapc4 36
  • 70.09 (n)
  • 73.17 (a)
Str.3790 36
zebrafish
(Danio rerio)
Actinopterygii anapc4 36
  • 64.74 (n)
  • 65.97 (a)
anapc4 37
  • 63 (a)
OneToOne
wufa95b03 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002345 36
  • 41.52 (n)
  • 32.24 (a)
fruit fly
(Drosophila melanogaster)
Insecta APC4 36
  • 40.24 (n)
  • 26.67 (a)
APC4 37
  • 24 (a)
OneToOne
Species with no ortholog for ANAPC4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ANAPC4 Gene

ENSEMBL:
Gene Tree for ANAPC4 (if available)
TreeFam:
Gene Tree for ANAPC4 (if available)

Paralogs for ANAPC4 Gene

No data available for Paralogs for ANAPC4 Gene

Variants for ANAPC4 Gene

Sequence variations from dbSNP and Humsavar for ANAPC4 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs9174 -- 25,417,661(+) CATTT(C/T)GAGAA synonymous-codon, reference, nc-transcript-variant
rs186408 -- 25,389,962(+) GGAAT(A/G)AGCCT intron-variant
rs315664 -- 25,409,021(+) gggac(C/T)actac intron-variant
rs315665 -- 25,407,071(-) TAGAT(G/T)ATAAG intron-variant
rs315666 -- 25,387,180(+) TGTGT(A/G)TAGTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ANAPC4 Gene

Variant ID Type Subtype PubMed ID
nsv509000 CNV Insertion 20534489

Relevant External Links for ANAPC4 Gene

HapMap Linkage Disequilibrium report
ANAPC4

Disorders for ANAPC4 Gene

Relevant External Links for ANAPC4

Genetic Association Database (GAD)
ANAPC4
genes like me logo Genes that share disorders with ANAPC4: view

No data available for UniProtKB/Swiss-Prot for ANAPC4 Gene

Publications for ANAPC4 Gene

  1. Identification of a cullin homology region in a subunit of the anaphase-promoting complex. (PMID: 9469815) Yu H. … Kirschner M.W. (Science 1998) 3 4 23
  2. Two subgroups of HLA Bw44 defined by cell-mediated lympholysis that differ in Bw44 expression on platelets and in patterns of genetic linkage disequilibrium. (PMID: 6180011) Tekolf W.A. … Shaw S. (J. Immunol. 1982) 2 3
  3. Mitotic regulation of the human anaphase-promoting complex by phosphorylation. (PMID: 14657031) Kraft C. … Peters J.-M. (EMBO J. 2003) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. Localization of the coactivator Cdh1 and the cullin subunit Apc2 in a cryo-electron microscopy model of vertebrate APC/C. (PMID: 16364912) Dube P. … Stark H. (Mol. Cell 2005) 3 4

Products for ANAPC4 Gene

Sources for ANAPC4 Gene

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