Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



ANAPC4 Gene

protein-coding   GIFtS: 57
GCID: GC04P025379

Anaphase Promoting Complex Subunit 4

  Search for ANAPC4
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Anaphase Promoting Complex Subunit 41 2
APC42 3 5
Cyclosome Subunit 42 3
Anaphase-Promoting Complex Subunit 42

External Ids:    HGNC: 199901   Entrez Gene: 299452   Ensembl: ENSG000000539007   OMIM: 6069475   UniProtKB: Q9UJX53   

Export aliases for ANAPC4 gene to outside databases

Previous GC identifers: GC04P025462 GC04P025067 GC04P025129 GC04P025055 GC04P024719


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for ANAPC4 Gene:
A large protein complex, termed the anaphase-promoting complex (APC), or the cyclosome, promotes
metaphase-anaphase transition by ubiquitinating its specific substrates such as mitotic cyclins and anaphase
inhibitor, which are subsequently degraded by the 26S proteasome. Biochemical studies have shown that the
vertebrate APC contains eight subunits. The composition of the APC is highly conserved in organisms from yeast to
humans. The exact function of this gene product is not known. Two transcript variants encoding different isoforms
have been found for this gene. (provided by RefSeq, Nov 2013)

GeneCards Summary for ANAPC4 Gene:
ANAPC4 (anaphase promoting complex subunit 4) is a protein-coding gene. GO annotations related to this gene include ubiquitin-protein ligase activity and protein phosphatase binding.

UniProtKB/Swiss-Prot: APC4_HUMAN, Q9UJX5
Function: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin
ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by
mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of
'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked
polyubiquitin chains

Gene Wiki entry for ANAPC4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000004.11  NT_006316.17  NC_018915.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ANAPC4 gene promoter:
         USF1   AML1a   POU3F1   Ik-3   MEF-2A   POU2F1   USF-1   POU2F1a   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ANAPC4 promoter sequence
   Search Chromatin IP Primers for ANAPC4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ANAPC4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p15.2   Ensembl cytogenetic band:  4p15.2   HGNC cytogenetic band: 4p15.31

ANAPC4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ANAPC4 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P025379:  view genomic region     (about GC identifiers)

Start:
25,378,835 bp from pter      End:
25,420,120 bp from pter
Size:
41,286 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: APC4_HUMAN, Q9UJX5 (See protein sequence)
Recommended Name: Anaphase-promoting complex subunit 4  
Size: 808 amino acids; 92116 Da
Subunit: The APC/C is composed of at least 12 subunits
Secondary accessions: A8K8H1 Q6PCC6 Q9NSH6
Alternative splicing: 2 isoforms:  Q9UJX5-1   Q9UJX5-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ANAPC4: NX_Q9UJX5

Explore proteomics data for ANAPC4 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ANAPC4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001273685.1  NP_037499.2  

    ENSEMBL proteins: 
     ENSP00000318775   ENSP00000426654   ENSP00000426512   ENSP00000421840  
    Reactome Protein details: Q9UJX5

    ANAPC4 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for ANAPC4
    GenScript Custom Purified and Recombinant Proteins Services for ANAPC4
    Novus Biologicals ANAPC4 Proteins
    Novus Biologicals ANAPC4 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ANAPC4

     
    Search eBioscience for Proteins for ANAPC4 

    ANAPC4 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for ANAPC4
    OriGene Custom Antibody Services for ANAPC4
    Novus Biologicals ANAPC4 Antibodies
    Abcam antibodies for ANAPC4
    Cloud-Clone Corp. Antibodies for ANAPC4
    ThermoFisher Antibodies for ANAPC4
    LSBio Antibodies in human, mouse, rat for ANAPC4

    ANAPC4 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ANAPC4
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ANAPC4
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ANAPC4
    Cloud-Clone Corp. CLIAs for ANAPC4
    Search eBioscience for ELISAs for ANAPC4 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    ANAPC: Anaphase promoting complex subunits

    Selected InterPro protein domains (see all 6):
     IPR024789 APC4
     IPR017169 APC4_metazoa
     IPR024977 Apc4_WD40_dom
     IPR017986 WD40_repeat_dom
     IPR015943 WD40/YVTN_repeat-like_dom

    Graphical View of Domain Structure for InterPro Entry Q9UJX5

    ProtoNet protein and cluster: Q9UJX5

    UniProtKB/Swiss-Prot: APC4_HUMAN, Q9UJX5
    Similarity: Belongs to the APC4 family


    Find genes that share domains with ANAPC4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: APC4_HUMAN, Q9UJX5
    Function: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin
    ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by
    mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of
    'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked
    polyubiquitin chains

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity TAS6180011
    GO:0005515protein binding IPI--
    GO:0019903protein phosphatase binding IPI--
         
    Find genes that share ontologies with ANAPC4           About GenesLikeMe


    Phenotypes:
         4 GenomeRNAi human phenotypes for ANAPC4:
     Increased ID2::GFP protein exp  Increased cell death in HCC-19  Synthetic lethal with Ras  Wnt reporter downregulated 

         1 MGI phenotypic allele for Anapc4 (no phenotypes)

    Find genes that share phenotypes with ANAPC4           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ANAPC4
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ANAPC4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ANAPC4
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ANAPC4

    miRNA
    Products:
        
    miRTarBase miRNAs that target ANAPC4:
    hsa-mir-124-3p (MIRT022718)

    Block miRNA regulation of human, mouse, rat ANAPC4 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate ANAPC4:
    hsa-miR-452
    SwitchGear 3'UTR luciferase reporter plasmidANAPC4 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ANAPC4
    Predesigned siRNA for gene silencing in human, mouse, rat ANAPC4

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ANAPC4

    Clone
    Products:
         
    OriGene clones in human, mouse for ANAPC4 (see all 7)
    OriGene ORF clones in mouse, rat for ANAPC4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ANAPC4 (NM_013367)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ANAPC4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ANAPC4

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ANAPC4
    Browse ESI BIO Cell Lines and PureStem Progenitors for ANAPC4 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANAPC4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    cytoskeleton2
    mitochondrion2
    golgi apparatus1
    plasma membrane1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005680anaphase-promoting complex IDA16364912
    GO:0005829cytosol TAS--

    Find genes that share ontologies with ANAPC4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for ANAPC4 About   (see all 22)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Inactivation of APC/C via direct inhibition of the APC/C complex
    Inactivation of APC/C via direct inhibition of the APC/C complex0.64
    Mitotic Spindle Checkpoint0.62
    APC/C-Cdc20 mediated degradation of Cyclin B0.64
    Common schema of ubiquitination0.33
    Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components0.64
    2Class I MHC mediated antigen processing and presentation
    Class I MHC mediated antigen processing and presentation0.84
    Adaptive Immune System0.41
    Antigen processing- Ubiquitination and Proteasome degradation0.84
    Ubiquitin mediated proteolysis0.35
    3CDK-mediated phosphorylation and removal of Cdc6
    APC/C-mediated degradation of cell cycle proteins0.94
    Activation of APC/C and APC/C-Cdc20 mediated degradation of mitotic proteins0.92
    Regulation of mitotic cell cycle0.94
    Autodegradation of Cdh1 by Cdh1-APC/C0.91
    Regulation of APC/C activators between G1/S and early anaphase0.94
    Cell Cycle Checkpoints0.58
    APC/C-Cdc20 mediated degradation of Securin0.93
    Phosphorylation of the APC/C0.00
    4Mitotic Metaphase and Anaphase
    Mitotic Anaphase0.94
    Mitotic Metaphase and Anaphase0.93
    Separation of Sister Chromatids0.94
    5Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    M Phase0.62
    Cell Cycle0.90


    Find genes that share SuperPaths with ANAPC4           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for ANAPC4 (see all 6)
        Activation of PKA through GPCR
    Remodeling of Adherens Junctions
    cAMP Pathway
    CDC42 Pathway
    Mitotic Roles of Polo Like Kinases

    Selected GeneGo (Thomson Reuters) Pathways for ANAPC4 (see all 7)
        Cell cycle Role of APC in cell cycle regulation
    G-protein signaling G-Protein alpha-s signaling cascades
    Signal transduction PKA signaling
    Cell cycle Regulation of G1/S transition (part 1)
    Cell cycle Spindle assembly and chromosome separation

    1 BioSystems Pathway for ANAPC4
        TGF-beta Receptor Signaling Pathway

    Selected Reactome Pathways for ANAPC4 (see all 12)
        APC/C:Cdc20 mediated degradation of mitotic proteins
    Autodegradation of Cdh1 by Cdh1:APC/C
    Phosphorylation of the APC/C
    Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
    APC/C:Cdc20 mediated degradation of Securin


    5 Kegg Pathways  (Kegg details for ANAPC4):
        Cell cycle
    Oocyte meiosis
    Ubiquitin mediated proteolysis
    Progesterone-mediated oocyte maturation
    HTLV-I infection

    UniProtKB/Swiss-Prot: APC4_HUMAN, Q9UJX5
    Pathway: Protein modification; protein ubiquitination

        Pathway & Disease-focused RT2 Profiler PCR Array including ANAPC4: 

              Ubiquitin Ligases in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for ANAPC4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ANAPC4 (Q9UJX51, 2, 3 ENSP000003187754) via UniProtKB, MINT, STRING, and/or I2D (see all 124)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NEK2P519551, 2, ENSP000003559664EBI-2554854,EBI-633182 MINT-8412949 MINT-8412968 MINT-8412937 MINT-8413199 MINT-8413025 MINT-8413062 STRING: ENSP00000355966
    KIF18AQ8NI771, 2EBI-2554854,EBI-355426 MINT-8412937 MINT-8412957
    BUB1BO605662, 3, ENSP000002875984MINT-8413231 MINT-8413199 MINT-8413062 I2D: score=2 STRING: ENSP00000287598
    ANAPC7Q9UJX32, 3, ENSP000003943944MINT-8413231 MINT-8413199 MINT-8413062 I2D: score=1 STRING: ENSP00000394394
    CDC20Q128342, 3, ENSP000003084504MINT-8413025 I2D: score=1 STRING: ENSP00000308450
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000086G2/M transition of mitotic cell cycle TAS9469815
    GO:0000090mitotic anaphase TAS9469815
    GO:0000278mitotic cell cycle TAS--
    GO:0006511ubiquitin-dependent protein catabolic process TAS9469815
    GO:0007067mitosis IEA--

    Find genes that share ontologies with ANAPC4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ANAPC4 (APC4)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for ANAPC4 gene (2 alternative transcripts): 
    NM_001286756.1  NM_013367.2  

    Unigene Cluster for ANAPC4:

    Anaphase promoting complex subunit 4
    Hs.152173  [show with all ESTs]
    Unigene Representative Sequence: AL353932
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000315368(uc003gro.3 uc003grp.3) ENST00000510092(uc010iet.1 uc010ieu.1)
    ENST00000505080 ENST00000505991 ENST00000507809 ENST00000507925 ENST00000503805
    ENST00000505842 ENST00000504256 ENST00000515848(uc003grq.3) ENST00000506973

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ANAPC4 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate ANAPC4:
    hsa-miR-452
    SwitchGear 3'UTR luciferase reporter plasmidANAPC4 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ANAPC4
    Predesigned siRNA for gene silencing in human, mouse, rat ANAPC4
    Clone
    Products:
         
    OriGene clones in human, mouse for ANAPC4 (see all 7)
    OriGene ORF clones in mouse, rat for ANAPC4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ANAPC4 (NM_013367)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ANAPC4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ANAPC4
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for ANAPC4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ANAPC4
      QuantiTect SYBR Green Assays in human, mouse, rat ANAPC4
      QuantiFast Probe-based Assays in human, mouse, rat ANAPC4

    Additional mRNA sequence: 

    AF191338.1 AK001881.1 AK023562.1 AK023597.1 AK292336.1 AL353932.1 AY429517.1 AY429518.1 
    BC059383.1 

    11 DOTS entries:

    DT.420654  DT.95368421  DT.40191933  DT.87077450  DT.97841353  DT.86851252  DT.102836230  DT.121234270 
    DT.91705239  DT.99972970  DT.121234264 

    Selected AceView cDNA sequences (see all 140):

    AW583671 AI200120 BM830490 BX956361 AA384939 BC059383 BQ632338 BP337824 
    AI335868 Z42287 AW513226 AI955406 BM683668 W73648 CA312572 CA975921 
    AW470099 AW196795 BQ006493 BU618246 BE883958 AI189513 NM_013367 AW583446 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ANAPC4 (see all 10)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b · 14c ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^
    SP1:                                                                                                        -           -                                       
    SP2:                                                                                                        -           -                                       
    SP3:                                                                                                                    -                                       
    SP4:                                                                                                                    -                                       
    SP5:                                                                                                                                                            

    ExUns: 20 ^ 21a · 21b ^ 22a · 22b ^ 23a · 23b ^ 24 ^ 25 ^ 26a · 26b ^ 27 ^ 28 ^ 29a · 29b · 29c
    SP1:                          -     -                             -                                 
    SP2:                          -     -                             -                                 
    SP3:                                                                                                
    SP4:                                                                                                
    SP5:                                                                                                


    ECgene alternative splicing isoforms for ANAPC4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    ANAPC4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGAGAGTATT
    ANAPC4 Expression
    About this image

    ANAPC4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ANAPC4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.152173
        Pathway & Disease-focused RT2 Profiler PCR Array including ANAPC4: 
              Ubiquitin Ligases in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for ANAPC4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ANAPC4
    QuantiTect SYBR Green Assays in human, mouse, rat ANAPC4
    QuantiFast Probe-based Assays in human, mouse, rat ANAPC4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANAPC4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for ANAPC4 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Anapc41 , 5 anaphase promoting complex subunit 41, 5 87.77(n)1
    93.56(a)1
      5 (28.81 cM)5
    522061  NM_024213.21  NP_077175.11 
     528340155 
    chicken
    (Gallus gallus)
    Aves ANAPC41 anaphase promoting complex subunit 4 77.97(n)
    78.64(a)
      422805  XM_004936144.1  XP_004936201.1 
    lizard
    (Anolis carolinensis)
    Reptilia ANAPC46
    anaphase promoting complex subunit 4
    73(a)
    1 ↔ 1
    GL343348.1(198371-232301)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.37902 Transcribed sequence with weak similarity to protein more 78.87(n)    BX714840.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufa95b032 Transcribed sequence with weak similarity to protein more 74.13(n)    AL916167.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta APC41 Anaphase Promoting Complex 4 40.24(n)
    26.67(a)
      31835  NM_132294.3  NP_572522.2 


    ENSEMBL Gene Tree for ANAPC4 (if available)
    TreeFam Gene Tree for ANAPC4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for ANAPC4 (see all 968)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0357924
    A colorectal cancer sample4--see VAR_0357922 I V mis40--------
    rs1451388221,2
    --25376927(+) GTTTAC/TGCCTC 1 -- us2k10--------
    rs1486614961,2
    C--25376937(+) CTGGGA/TACAGT 1 -- us2k10--------
    rs1892654721,2
    --25376962(+) GTATGC/GGTGTT 1 -- us2k10--------
    rs1421704631,2
    --25377177(+) GTTTGC/TGGCAA 1 -- us2k10--------
    rs3156821,2
    C,H--25377192(-) TTGCAA/GCCCTT 1 -- us2k117Minor allele frequency- G:0.12MN EA NA WA CSA 606
    rs1822142111,2
    --25377217(+) AGCAGC/GGTAGG 1 -- us2k10--------
    rs1872090381,2
    --25377227(+) GTATAA/GAGTCA 1 -- us2k10--------
    rs1910401751,2
    --25377388(+) TTTGAA/GCAAGT 1 -- us2k10--------
    rs1828663471,2
    --25377458(+) ATGGTA/GCTGTC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ANAPC4 (25378835 - 25420120 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for ANAPC4:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv509000CNV Insertion20534489

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ANAPC4
    DNA2.0 Custom Variant and Variant Library Synthesis for ANAPC4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 606947    OMIM disorders: --


    Find genes that share disorders with ANAPC4           About GenesLikeMe

    Genetic Association Database (GAD): ANAPC4

    Export disorders for ANAPC4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for ANAPC4 gene, integrated from 10 sources (see all 62):
    (articles sorted by number of sources associating them with ANAPC4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a cullin homology region in a subunit of the anaphase-promoting complex. (PubMed id 9469815)1, 2, 9 Yu H.... Kirschner M.W. (Science 1998)
    2. Genome-wide association study of anthropometric traits and evidence of interactions with age and study year in Filipino women. (PubMed id 20966902)1, 4 Croteau-Chonka D.C....Mohlke K.L. (Obesity (Silver Spring) 2011)
    3. Mechanism of ubiquitin-chain formation by the human anaphase- promoting complex. (PubMed id 18485873)1, 2 Jin L.... Rape M. (Cell 2008)
    4. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. (PubMed id 17554300)1, 4 (Nature 2007)
    5. Localization of the coactivator Cdh1 and the cullin subunit Apc2 in a cryo-electron microscopy model of vertebrate APC/C. (PubMed id 16364912)1, 2 Dube P.... Stark H. (Mol. Cell 2005)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. Mitotic regulation of the human anaphase-promoting complex by phosphorylation. (PubMed id 14657031)1, 2 Kraft C....Peters J.-M. (EMBO J. 2003)
    8. Two subgroups of HLA Bw44 defined by cell-mediated lympholysis that differ in Bw44 expression on platelets and in patterns of genetic linkage disequilibrium. (PubMed id 6180011)1, 3 Tekolf W.A....Shaw S. (J. Immunol. 1982)
    9. The G2/M regulator histone demethylase PHF8 is targeted for degradation by the anaphase-promoting complex containing CDC20. (PubMed id 23979597)1 Lim H.J....Shi Y. (Mol. Cell. Biol. 2013)
    10. The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells. (PubMed id 23667531)1 Cox J.L....Rizzino A. (PLoS ONE 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 29945 HGNC: 19990 AceView: ANAPC4 Ensembl:ENSG00000053900 euGenes: HUgn29945
    ECgene: ANAPC4 Kegg: 29945 H-InvDB: ANAPC4

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for ANAPC4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for ANAPC4 gene:
    Search GeneIP for patents involving ANAPC4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for ANAPC4   OriGene RNAi products in human, mouse, rat for ANAPC4  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for ANAPC4  
     OriGene qSTAR qPCR primer pairs in human, mouse for ANAPC4   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for ANAPC4   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ANAPC4   OriGene Custom Protein Services for ANAPC4  

     
     
     Block miRNA regulation of human, mouse, rat ANAPC4 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing ANAPC4
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ANAPC4 Predesigned siRNA for gene silencing in human, mouse, rat ANAPC4
     QuantiFast Probe-based Assays in human, mouse, rat ANAPC4 QuantiTect SYBR Green Assays in human, mouse, rat ANAPC4
     PCR Arrays including human, mouse, rat ANAPC4 Search Chromatin IP Primers for ANAPC4
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ANAPC4  Search GeneGlobe Interaction Network for ANAPC4
     Regulatory tfbs in ANAPC4 promoter
     GenScript Custom Purified and Recombinant Proteins Services for ANAPC4 GenScript cDNA clones with any tag delivered in your preferred vector for ANAPC4
     GenScript Custom Assay Services for ANAPC4 GenScript Custom overexpressing Cell Line Services for ANAPC4
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for ANAPC4 (APC4)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     ANAPC4 antibodies
     ANAPC4 proteins
     ANAPC4 lysates
     Antibodies for ANAPC4
     See all of Abcam's Antibodies, Kits and Proteins for ANAPC4
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for ANAPC4
     Antibodies for ANAPC4
     ELISAs for ANAPC4
     CLIAs for ANAPC4



     Browse ESI BIO Cell Lines and PureStem Progenitors for ANAPC4
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANAPC4
     SwitchGear 3'UTR luciferase reporter plasmids for ANAPC4
     SwitchGear Promoter luciferase reporter plasmids for ANAPC4
     ThermoFisher Antibodies for ANAPC4
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ANAPC4
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ANAPC4
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ANAPC4
     LSBio Antibodies in human, mouse, rat for ANAPC4
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for ANAPC4
      Search eBioscience for proteins for ANAPC4
      Search eBioscience for elisas for ANAPC4
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      ANAPC4 gene at Home site.
    Version: 3.12.212 17 Sep 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4