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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ANAPC4 Gene

protein-coding   GIFtS: 54
GCID: GC04P025462

anaphase promoting complex subunit 4

 Explore 2 diseases affiliated with
ANAPC4 via our new
 Human Malady Compendium 
Biological research products
for ANAPC4
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Anaphase Promoting Complex Subunit 41 2
APC41 2 3 5
Cyclosome Subunit 42 3
Anaphase-Promoting Complex Subunit 42

External Ids:    HGNC: 199901   Entrez Gene: 299452   Ensembl: ENSG000000539007   OMIM: 6069475   UniProtKB: Q9UJX53   

Export aliases for ANAPC4 gene to outside databases

Previous GC identifers: GC04P025067 GC04P025129 GC04P025055 GC04P024719


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ANAPC4:
A large protein complex, termed the anaphase-promoting complex (APC), or the cyclosome, promotes metaphase-anaphase
transition by ubiquitinating its specific substrates such as mitotic cyclins and anaphase inhibitor, which are
subsequently degraded by the 26S proteasome. Biochemical studies have shown that the vertebrate APC contains eight
subunits. The composition of the APC is highly conserved in organisms from yeast to humans. The exact function of this
gene product is not known. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: APC4_HUMAN, Q9UJX5
Function: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase
that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating
ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked
polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains

Gene Wiki entry for ANAPC4


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.1  NT_006316.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ANAPC4 gene promoter:
         USF1   AML1a   POU3F1   Ik-3   MEF-2A   POU2F1   USF-1   POU2F1a   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ANAPC4 promoter sequence
   Search SABiosciences Chromatin IP Primers for ANAPC4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ANAPC4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p15.2   Ensembl cytogenetic band:  4p15.2   HGNC cytogenetic band: 4p15.31

ANAPC4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ANAPC4 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P025462:  view genomic region     (about GC identifiers)

Start:
25,378,835 bp from pter      End:
25,420,120 bp from pter
Size:
41,286 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: APC4_HUMAN, Q9UJX5 (See protein sequence)
Recommended Name: Anaphase-promoting complex subunit 4  
Size: 808 amino acids; 92116 Da
Subunit: The APC/C is composed of at least 12 subunits
Secondary accessions: A8K8H1 Q6PCC6 Q9NSH6
Alternative splicing: 2 isoforms:  Q9UJX5-1   Q9UJX5-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ANAPC4: NX_Q9UJX5

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9UJX5

  • ANAPC4 Protein expression data from MOPED and PaxDb:    About this image 
    ANAPC4 Protein Expression
    REFSEQ proteins: NP_037499.2  
    ENSEMBL proteins: 
     ENSP00000318775   ENSP00000426654   ENSP00000426512   ENSP00000421840  
    Reactome Protein details: Q9UJX5
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    Uscn Proteins for ANAPC4

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005680anaphase-promoting complex IDA--
    GO:0005829cytosol TAS--

    ANAPC4 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ANAPC4 for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR024789 APC4
     IPR017986 WD40_repeat_dom
     IPR015943 WD40/YVTN_repeat-like_dom
     IPR017169 APC4_metazoa
     IPR024790 APC4_long_dom

    Graphical View of Domain Structure for InterPro Entry Q9UJX5

    ProtoNet protein and cluster: Q9UJX5

    UniProtKB/Swiss-Prot: APC4_HUMAN, Q9UJX5
    Similarity: Belongs to the APC4 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: APC4_HUMAN, Q9UJX5
    Function: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase
    that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating
    ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked
    polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity TAS6180011
    GO:0019903protein phosphatase binding IPI--
         
    ANAPC4 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for ANAPC4:
     Increased ID2::GFP protein exp  Increased cell death in HCC-19  Synthetic lethal with Ras  Wnt reporter downregulated 

    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/22 super-pathways (see all 22About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Ubiquitinated Orc1 is degraded by the proteasome
    8/15 pathways (see all 15)
    APC/C:Cdh1-mediated degradation of Skp20.74
    APC/C:Cdc20 mediated degradation of mitotic proteins0.69
    APC/C:Cdc20 mediated degradation of Securin0.74
    APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G10.69
    Degradation of multiubiquitinated Securin0.74
    Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins0.68
    Autodegradation of Cdh1 by Cdh1:APC/C0.70
    Regulation of APC/C activators between G1/S and early anaphase0.62
    2APC-Cdc20 mediated degradation of Nek2A
    8/10 pathways (see all 10)
    Degradation of multiubiquitinated Nek2A1.00
    Degradation of multiubiquitinated Cyclin B0.76
    APC-Cdc20 mediated degradation of Nek2A1.00
    Mitotic Spindle Checkpoint0.75
    Inactivation of APC/C via direct inhibition of the APC/C complex0.78
    Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase0.60
    Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components0.78
    Phosphorylation of the APC/C0.54
    3M Phase
    M Phase1.00
    Mitotic Anaphase0.85
    Mitotic M-M/G1 phases0.88
    Separation of Sister Chromatids0.80
    Mitotic Metaphase and Anaphase0.85
    4Antigen processing: Ubiquitination & Proteasome degradation
    Antigen processing: Ubiquitination & Proteasome degradation1.00
    Polyubiquitination of substrate0.75
    Class I MHC mediated antigen processing & presentation0.83
    Ubiquitin mediated proteolysis0.36
    5Cell cycle_Spindle assembly and chromosome separation
    Cell cycle_Spindle assembly and chromosome separation1.00
    Cell cycle Spindle assembly and chromosome separation0.94

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5/9 EMD Millipore Pathways for ANAPC4 (see all 9)
        Cell cycle Role of APC in cell cycle regulation
    Meiosis
    Cell cycle Regulation of G1/S transition (part 1)
    Development TGF-beta receptor signaling
    Signal transduction PKA signaling

    5/6 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for ANAPC4 (see all 6)
        Activation of PKA through GPCR
    Remodeling of Adherens Junctions
    cAMP Pathway
    CDC42 Pathway
    Mitotic Roles of Polo Like Kinases

    5/7 GeneGo (Thomson Reuters) Pathways for ANAPC4 (see all 7)
        Cell cycle Role of APC in cell cycle regulation
    G-protein signaling G-Protein alpha-s signaling cascades
    Signal transduction PKA signaling
    Cell cycle Regulation of G1/S transition (part 1)
    Cell cycle Spindle assembly and chromosome separation

    1 BioSystems Pathway for ANAPC4 
        TGF-beta Receptor Signaling Pathway

    5/36        Reactome Pathways for ANAPC4 (see all 36)
        APC/C:Cdc20 mediated degradation of mitotic proteins
    Phosphorylation of the APC/C
    APC/C:Cdc20 mediated degradation of Securin
    Cdc20:Phospho-APC/C mediated degradation of Cyclin A
    Antigen processing: Ubiquitination & Proteasome degradation


    4         Kegg Pathways  (Kegg details for ANAPC4):
        Cell cycle
    Oocyte meiosis
    Ubiquitin mediated proteolysis
    Progesterone-mediated oocyte maturation

    UniProtKB/Swiss-Prot: APC4_HUMAN, Q9UJX5
    Pathway: Protein modification; protein ubiquitination


    ANAPC4 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ANAPC4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/105 Interacting proteins for ANAPC4 (Q9UJX52, 3 ENSP000003187754) via UniProtKB, MINT, STRING, and/or I2D (see all 105)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    NEK2P519552, ENSP000003559664MINT-8412949 MINT-8412968 MINT-8412937 MINT-8413199 MINT-8413025 MINT-8413062 STRING: ENSP00000355966
    BUB1BO605662, 3, ENSP000002875984MINT-8413231 MINT-8413199 MINT-8413062 I2D: score=2 STRING: ENSP00000287598
    ANAPC7Q9UJX32, 3, ENSP000003943944MINT-8413231 MINT-8413199 MINT-8413062 I2D: score=1 STRING: ENSP00000394394
    CDC20Q128342, 3, ENSP000003084504MINT-8413025 I2D: score=1 STRING: ENSP00000308450
    MAD2L1Q132572, ENSP000002965094MINT-8413199 MINT-8413025 STRING: ENSP00000296509
    About this table

    Gene Ontology (GO): 5/15 biological process terms (GO ID links to tree view) (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000075cell cycle checkpoint TAS--
    GO:0000086G2/M transition of mitotic cell cycle TAS9469815
    GO:0000090mitotic anaphase TAS9469815
    GO:0000278mitotic cell cycle TAS--
    GO:0006511ubiquitin-dependent protein catabolic process TAS9469815

    ANAPC4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Search CenterWatch for drugs/clinical trials and news about ANAPC4 / APC4 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    About This Section

    REFSEQ mRNAs for ANAPC4 gene: 
    NM_013367.2  

    Unigene Cluster for ANAPC4:

    Anaphase promoting complex subunit 4
    Hs.152173  [show with all ESTs]
    Unigene Representative Sequence: AL353932
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000315368(uc003gro.3 uc003grp.3) ENST00000510092(uc010iet.1 uc010ieu.1)
    ENST00000505080 ENST00000505991 ENST00000507809 ENST00000507925 ENST00000503805
    ENST00000505842 ENST00000504256 ENST00000515848(uc003grq.3) ENST00000506973


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    Additional cDNA sequence: 

    AF191338.1 AK001881.1 AK023562.1 AK023597.1 AK292336.1 AL353932.1 AY429517.1 AY429518.1 
    BC059383.1 

    11 DOTS entries:

    DT.420654  DT.95368421  DT.40191933  DT.87077450  DT.97841353  DT.86851252  DT.102836230  DT.121234270 
    DT.91705239  DT.99972970  DT.121234264 

    24/140 AceView cDNA sequences (see all 140):

    Z38516 AW583671 AA384939 BC059383 BQ632338 AI200120 N63100 BP337824 
    BM683668 W73648 AI955406 CA975921 NM_013367 CA312572 AW513226 AW470099 
    AA428784 AW583446 BM479644 BQ011691 AI189513 AI979163 BX956361 Z42287 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for ANAPC4 (see all 10)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b · 14c ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^
    SP1:                                                                                                        -           -                                       
    SP2:                                                                                                        -           -                                       
    SP3:                                                                                                                    -                                       
    SP4:                                                                                                                    -                                       
    SP5:                                                                                                                                                            

    ExUns: 20 ^ 21a · 21b ^ 22a · 22b ^ 23a · 23b ^ 24 ^ 25 ^ 26a · 26b ^ 27 ^ 28 ^ 29a · 29b · 29c
    SP1:                          -     -                             -                                 
    SP2:                          -     -                             -                                 
    SP3:                                                                                                
    SP4:                                                                                                
    SP5:                                                                                                


    ECgene alternative splicing isoforms for ANAPC4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ANAPC4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGAGAGTATT
    ANAPC4 Expression
    About this image
    See ANAPC4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ANAPC4

    SOURCE GeneReport for Unigene cluster: Hs.152173
        SABiosciences Expression via Pathway-Focused PCR Array including ANAPC4: 

              Ubiquitin Ligases in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ANAPC4 gene from 8/23 species (see all 23)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Anapc41 , 5 anaphase promoting complex subunit 41, 5 87.77(n)1
    93.56(a)1
      5 (28.81 cM)5
    522061  NM_024213.21  NP_077175.11 
     528340155 
    chicken
    (Gallus gallus)
    Aves ANAPC41 anaphase promoting complex subunit 4 76.61(n)
    75.98(a)
      422805  XM_001231776.2  XP_001231777.1 
    lizard
    (Anolis carolinensis)
    Reptilia ANAPC46
    --
    73(a)
    1 ↔ 1
    GL343348.1(198374-227849)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.37902 Transcribed sequence with weak similarity to protein more 78.87(n)    BX714840.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufa95b032 Transcribed sequence with weak similarity to protein more 74.13(n)    AL916167.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta APC41 Anaphase Promoting Complex 4 40.37(n)
    26.34(a)
      31835  NM_132294.3  NP_572522.2 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT4G215301 anaphase-promoting complex subunit 4 42.58(n)
    26.01(a)
      828238  NM_118273.7  NP_193884.6 
    rice
    (Oryza sativa)
    Liliopsida Os02g07859001 hypothetical protein 41.72(n)
    28.68(a)
      4330947  NM_001054866.2  NP_001048331.2 


    ENSEMBL Gene Tree for ANAPC4 (if available)
    TreeFam Gene Tree for ANAPC4 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/807 NCBI SNPs in ANAPC4 are shown (see all 807    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1451388221,2
    --25376927(+) GTTTAC/TGCCTC 1 -- us2k10--------
    rs1486614961,2
    --25376937(+) CTGGGA/TACAGT 1 -- us2k10--------
    rs1892654721,2
    --25376962(+) GTATGC/GGTGTT 1 -- us2k10--------
    rs1421704631,2
    --25377177(+) GTTTGC/TGGCAA 1 -- us2k10--------
    rs3156821,2
    C,H--25377192(-) TTGCAA/GCCCTT 1 -- us2k117Minor allele frequency- G:0.12MN EA NA WA CSA 606
    rs1822142111,2
    --25377217(+) AGCAGC/GGTAGG 1 -- us2k10--------
    rs1872090381,2
    --25377227(+) GTATAA/GAGTCA 1 -- us2k10--------
    rs1910401751,2
    --25377388(+) TTTGAA/GCAAGT 1 -- us2k10--------
    rs1828663471,2
    --25377458(+) ATGGTA/GCTGTC 1 -- us2k10--------
    rs1416687271,2
    --25377577(+) GGCTGA/GCCTGT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ANAPC4 (25378835 - 25420120 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for ANAPC4: --

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ANAPC4 for disorders           About GeneDecksing

    OMIM gene information: 606947    OMIM disorders: --

    2 diseases for ANAPC4:    About MalaCards
    cytomegalovirus infection    neuronitis


    Export disorders for ANAPC4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ANAPC4 gene, integrated from 9 sources (see all 52):
    (articles sorted by number of sources associating them with ANAPC4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a cullin homology region in a subunit of the anaphase-promoting complex. (PubMed id 9469815)1, 2, 9 Yu H.... Kirschner M.W. (1998)
    2. Mechanism of ubiquitin-chain formation by the human anaphase-promoting complex. (PubMed id 18485873)1, 2 Jin L....Rape M. (2008)
    3. Localization of the coactivator Cdh1 and the cullin subunit Apc2 in a cryo-electron microscopy model of vertebrate APC/C. (PubMed id 16364912)1, 2 Dube P.... Stark H. (2005)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. Mitotic regulation of the human anaphase-promoting complex by phosphorylation. (PubMed id 14657031)1, 2 Kraft C....Peters J.-M. (2003)
    6. Two subgroups of HLA Bw44 defined by cell-mediated lympholysis that differ in Bw44 expression on platelets and in patterns of genetic linkage disequilibrium. (PubMed id 6180011)1, 3 Tekolf W.A....Shaw S. (1982)
    7. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    8. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)
    9. A cohesin-RAD21 interactome. (PubMed id 22145905)1 Panigrahi A.K....Pati D. (2012)
    10. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 29945 HGNC: 19990 AceView: ANAPC4 Ensembl:ENSG00000053900 euGenes: HUgn29945
    ECgene: ANAPC4 Kegg: 29945 H-InvDB: ANAPC4

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ANAPC4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ANAPC4 gene:
    Search GeneIP for patents involving ANAPC4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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