Aliases for ANAPC4 Gene
Aliases for ANAPC4 Gene
External Ids for ANAPC4 Gene
- HGNC: 19990
- Entrez Gene: 29945
- Ensembl: ENSG00000053900
- OMIM: 606947
- UniProtKB: Q9UJX5
Previous GeneCards Identifiers for ANAPC4 Gene
- GC04P025462
- GC04P025067
- GC04P025129
- GC04P025055
- GC04P024719
Summaries for ANAPC4 Gene
-
A large protein complex, termed the anaphase-promoting complex (APC), or the cyclosome, promotes metaphase-anaphase transition by ubiquitinating its specific substrates such as mitotic cyclins and anaphase inhibitor, which are subsequently degraded by the 26S proteasome. Biochemical studies have shown that the vertebrate APC contains eight subunits. The composition of the APC is highly conserved in organisms from yeast to humans. The exact function of this gene product is not known. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]
GeneCards Summary for ANAPC4 Gene
ANAPC4 (Anaphase Promoting Complex Subunit 4) is a Protein Coding gene. Among its related pathways are G-protein signaling G-Protein alpha-i signaling cascades and APC-Cdc20 mediated degradation of Nek2A. GO annotations related to this gene include ubiquitin-protein transferase activity and protein phosphatase binding.
UniProtKB/Swiss-Prot for ANAPC4 Gene
-
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of Lys-11-linked polyubiquitin chains and, to a lower extent, the formation of Lys-48- and Lys-63-linked polyubiquitin chains.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANAPC4 Gene
Genomics for ANAPC4 Gene
Regulatory Elements for ANAPC4 Gene
Enhancers for ANAPC4 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH04G025309 | 1.4 | Ensembl ENCODE | 48.5 | -66.5 | -66525 | 1.7 | HNRNPUL1 HDGF CREB3L1 ARNT MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 | ANAPC4 DHX15 ZCCHC4 GC04P025283 |
| GH04G025158 | 1.1 | ENCODE | 45.9 | -216.7 | -216654 | 3.8 | HDGF FOXA2 CREB3L1 MLX WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 | ANAPC4 DHX15 PI4K2B SEPSECS PIR60918 |
| GH04G025376 | 1 | ENCODE | 44.1 | +0.3 | 253 | 2.2 | HDGF ATF1 PKNOX1 CREB3L1 AGO1 ARID4B SIN3A BRCA1 ZNF48 YY1 | ANAPC4 LOC105374536 |
| GH04G025312 | 1.1 | ENCODE | 39.1 | -64.1 | -64146 | 1.9 | HDGF HNRNPUL1 MLX CREB3L1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 | ANAPC4 PI4K2B ZCCHC4 PIR58322 |
| GH04G025320 | 0.8 | Ensembl ENCODE | 48.5 | -56.1 | -56107 | 1.5 | MXI1 ZNF316 JUND CEBPB MYC PRDM1 EP300 | ANAPC4 ZCCHC4 PIR58322 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around ANAPC4 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for ANAPC4 Gene
- Chromosome:
- 4
- Start:
- 25,377,213 bp from pter
- End:
- 25,418,498 bp from pter
- Size:
- 41,286 bases
- Orientation:
- Plus strand
Genomic View for ANAPC4 Gene
Genes around ANAPC4 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 4p15.2 by Ensembl
- 4p15.2 by Entrez Gene
- 4p15.2 by HGNC
ANAPC4 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ANAPC4 Gene
Proteins for ANAPC4 Gene
-
Protein details for ANAPC4 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9UJX5-APC4_HUMAN
- Recommended name:
- Anaphase-promoting complex subunit 4
- Protein Accession:
- Q9UJX5
- A8K8H1
- E9PCR4
- Q6PCC6
- Q9NSH6
Protein attributes for ANAPC4 Gene
- Size:
- 808 amino acids
- Molecular mass:
- 92116 Da
- Quaternary structure:
-
- The mammalian APC/C is composed of 14 distinct subunits that assemble into a complex of at least 19 chains with a combined molecular mass of around 1.2 MDa.
Three dimensional structures from OCA and Proteopedia for ANAPC4 Gene
Protein Expression for ANAPC4 Gene
Post-translational modifications for ANAPC4 Gene
Other Protein References for ANAPC4 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
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- antibodies-online Antibodies for ANAPC4: See all 46
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-
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-
Santa Cruz Biotechnology (SCBT) Antibodies for ANAPC4
Protein Products
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Assay Products
- antibodies-online Kits for ANAPC4: See all 8
No data available for DME Specific Peptides for ANAPC4 Gene
Domains & Families for ANAPC4 Gene
Gene Families for ANAPC4 Gene
Protein Domains for ANAPC4 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for ANAPC4 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9UJX5- Family:
-
- Belongs to the APC4 family.
Function for ANAPC4 Gene
Molecular function for ANAPC4 Gene
- UniProtKB/Swiss-Prot Function:
- Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of Lys-11-linked polyubiquitin chains and, to a lower extent, the formation of Lys-48- and Lys-63-linked polyubiquitin chains.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004842 | ubiquitin-protein transferase activity | TAS | 6180011 |
| GO:0005515 | protein binding | IPI | 23288039 |
| GO:0019903 | protein phosphatase binding | IPI | 21241890 |
Phenotypes for ANAPC4 Gene
- MGI mutant phenotypes for ANAPC4:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for ANAPC4:
-
- Increased viability
- Increased vaccinia virus (VACV) infection
- shRNA abundance <= 50%
- Synthetic lethal with Ras
- Dynamic nuclei (hole, folded or small irregular)
- Increased transferrin (TF) endocytosis
- Negative genetic interaction between KRASG13D/+ and KRAS+/-
- Effect on mitosis
- Wnt reporter downregulated
- Increased cell death HMECs cells
- Increased ID2::GFP protein expression
Animal Models for ANAPC4 Gene
- MGI Knock Outs for ANAPC4:
-
- Anapc4 tm1b(EUCOMM)Wtsi
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for ANAPC4
-
-
ViGene Biosciences lentiviral particle packaged cDNA for ANAPC4 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for ANAPC4 gene
- Search ViGene Biosciences for ANAPC4
CRISPR Products
-
OriGene CRISPR knockouts for ANAPC4
-
Santa Cruz Biotechnology (SCBT) CRISPR for ANAPC4
- GenScript: Design CRISPR guide RNA sequences for ANAPC4
miRNA for ANAPC4 Gene
- miRTarBase miRNAs that target ANAPC4
miRNA Products
- Search ViGene Biosciences for ANAPC4
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for ANAPC4
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-
ViGene Biosciences ready-to-package AAV shRNAs for ANAPC4 gene
Clone Products
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- VectorBuilder custom plasmid, inducible vectors for ANAPC4
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for ANAPC4 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for ANAPC4 gene
-
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Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ANAPC4 Gene
Localization for ANAPC4 Gene
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| cytoskeleton | 3 |
| mitochondrion | 2 |
| plasma membrane | 1 |
| golgi apparatus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IDA | 21241890 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005680 | anaphase-promoting complex | IEA,IDA | 16364912 |
| GO:0005829 | cytosol | TAS | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for ANAPC4 Gene
Pathways & Interactions for ANAPC4 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | CDK-mediated phosphorylation and removal of Cdc6 | ||
| 2 | APC-Cdc20 mediated degradation of Nek2A | ||
| 3 | Class I MHC mediated antigen processing and presentation | ||
| 4 | Cell Cycle, Mitotic |
.83
|
.60
|
| 5 | Cellular Senescence | ||
Pathways by source for ANAPC4 Gene
31 Reactome pathways for ANAPC4 Gene
5 KEGG pathways for ANAPC4 Gene
7 GeneGo (Thomson Reuters) pathways for ANAPC4 Gene
6 Qiagen pathways for ANAPC4 Gene
UniProtKB/Swiss-Prot Q9UJX5-APC4_HUMAN
- Pathway: Protein modification; protein ubiquitination.
Interacting Proteins for ANAPC4 Gene
Selected Interacting proteins:
ENSP00000318775
Q9UJX5-APC4_HUMAN
for ANAPC4 Gene via
STRING
MINT
IID
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007049 | cell cycle | IEA | -- |
| GO:0007067 | mitotic nuclear division | IEA | -- |
| GO:0016567 | protein ubiquitination | IEA | -- |
| GO:0030071 | regulation of mitotic metaphase/anaphase transition | IEA | -- |
| GO:0031145 | anaphase-promoting complex-dependent catabolic process | IEA,TAS | -- |
No data available for SIGNOR curated interactions for ANAPC4 Gene
Transcripts for ANAPC4 Gene
mRNA/cDNA for ANAPC4 Gene
- (6) REFSEQ mRNAs :
- (9) Additional mRNA sequences :
- (140) Selected AceView cDNA sequences:
- (11) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for ANAPC4 Gene
CRISPR Products
-
OriGene CRISPR knockouts for ANAPC4
-
Santa Cruz Biotechnology (SCBT) CRISPR for ANAPC4
- GenScript: Design CRISPR guide RNA sequences for ANAPC4
miRNA Products
- Search ViGene Biosciences for ANAPC4
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for ANAPC4
- Browse OriGene Inhibitory RNA Products For ANAPC4
-
ViGene Biosciences ready-to-package AAV shRNAs for ANAPC4 gene
Clone Products
-
OriGene ORF clones in human for ANAPC4
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for ANAPC4
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ANAPC4
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14a | · | 14b | · | 14c | ^ | 15a | · | 15b | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| SP9: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: |
| ExUns: | 20 | ^ | 21a | · | 21b | ^ | 22a | · | 22b | ^ | 23a | · | 23b | ^ | 24 | ^ | 25 | ^ | 26a | · | 26b | ^ | 27 | ^ | 28 | ^ | 29a | · | 29b | · | 29c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||||||||||||||
| SP2: | - | - | - | ||||||||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||||||||
| SP5: | |||||||||||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||||||||||
| SP7: | - | ||||||||||||||||||||||||||||||
| SP8: | |||||||||||||||||||||||||||||||
| SP9: | |||||||||||||||||||||||||||||||
| SP10: |
Expression for ANAPC4 Gene
This gene is overexpressed in Lung (22.0) and Breast (19.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ANAPC4 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of ANAPC4 Gene:
ANAPC4SOURCE GeneReport for Unigene cluster for ANAPC4 Gene:
Hs.152173Evidence on tissue expression from TISSUES for ANAPC4 Gene
- Nervous system(4.4)
Primer Products
-
OriGene qPCR primer pairs for ANAPC4
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ANAPC4 Gene
Orthologs for ANAPC4 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ANAPC4 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | ANAPC4 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | ANAPC4 34 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Anapc4 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Anapc4 34 16 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | ANAPC4 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 35 |
|
OneToMany | |
| -- 35 |
|
OneToMany | |||
| chicken (Gallus gallus) |
Aves | ANAPC4 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | ANAPC4 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | anapc4 34 |
|
||
| Str.3790 34 |
|
||||
| zebrafish (Danio rerio) |
Actinopterygii | anapc4 34 35 |
|
||
| wufa95b03 34 |
|
||||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP002345 34 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | APC4 34 35 |
|
- Species where no ortholog for ANAPC4 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for ANAPC4 Gene
No data available for Paralogs for ANAPC4 Gene
Variants for ANAPC4 Gene
| SNP ID | Clin | Chr 04 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| VAR_035792 | A colorectal cancer sample | ||||
| rs1000030943 | -- | 25,407,387(+) | AGTTT(A/T)TAAAC | intron-variant | |
| rs1000086215 | -- | 25,399,297(+) | TCCCA(A/G)TATGT | intron-variant | |
| rs10001307 | -- | 25,390,361(+) | ATTTC(C/T)TTACT | intron-variant | |
| rs10001352 | -- | 25,411,352(+) | TCCTC(G/T)TTTAT | intron-variant |
Residual Variation Intolerance Score:
6.23% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
5.20;
69.80% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for ANAPC4 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- ANAPC4
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANAPC4 Gene
Disorders for ANAPC4 Gene
Relevant External Links for ANAPC4
No disorders were found for ANAPC4 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANAPC4 Gene
Publications for ANAPC4 Gene
- Identification of a cullin homology region in a subunit of the anaphase-promoting complex. (PMID: 9469815) Yu H. … Kirschner M.W. (Science 1998) 3 4 22 64
- Molecular architecture and mechanism of the anaphase-promoting complex. (PMID: 25043029) Chang L. … Barford D. (Nature 2014) 3 4 64
- Genome-wide association study of anthropometric traits and evidence of interactions with age and study year in Filipino women. (PMID: 20966902) Croteau-Chonka D.C. … Mohlke K.L. (Obesity (Silver Spring) 2011) 3 46 64
- Mechanism of ubiquitin-chain formation by the human anaphase- promoting complex. (PMID: 18485873) Jin L. … Rape M. (Cell 2008) 3 4 64
- Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. (PMID: 17554300) (Nature 2007) 3 46 64
Products for ANAPC4 Gene
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- Novus Biologicals Antibodies for ANAPC4
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- Novus Biologicals
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- antibodies-online Antibodies for ANAPC4: See all 46
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- Search antibodies-online for proteins
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- GeneTex ANAPC4 antibody for ANAPC4
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- ViGene Biosciences adenoviral particle packaged cDNA for ANAPC4 gene
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- Search for ANAPC4 Proteins at ProSci
- Cyagen custom Knockout/knockin (KOKI) mouse models for ANAPC4
- VectorBuilder custom plasmid, inducible vectors for ANAPC4
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ANAPC4
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for ANAPC4 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
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