Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ANAPC4 Gene

protein-coding   GIFtS: 57
GCID: GC04P025462

Anaphase Promoting Complex Subunit 4

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Anaphase Promoting Complex Subunit 41 2
APC42 3 5
Cyclosome Subunit 42 3
Anaphase-Promoting Complex Subunit 42

External Ids:    HGNC: 199901   Entrez Gene: 299452   Ensembl: ENSG000000539007   OMIM: 6069475   UniProtKB: Q9UJX53   

Export aliases for ANAPC4 gene to outside databases

Previous GC identifers: GC04P025067 GC04P025129 GC04P025055 GC04P024719


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ANAPC4 Gene:
A large protein complex, termed the anaphase-promoting complex (APC), or the cyclosome, promotes
metaphase-anaphase transition by ubiquitinating its specific substrates such as mitotic cyclins and anaphase
inhibitor, which are subsequently degraded by the 26S proteasome. Biochemical studies have shown that the
vertebrate APC contains eight subunits. The composition of the APC is highly conserved in organisms from yeast to
humans. The exact function of this gene product is not known. (provided by RefSeq, Jul 2008)

GeneCards Summary for ANAPC4 Gene: 
ANAPC4 (anaphase promoting complex subunit 4) is a protein-coding gene. Diseases associated with ANAPC4 include cytomegalovirus infection, and neuronitis, and among its related super-pathways are Mitotic Spindle Checkpoint and Antigen processing: Ubiquitination & Proteasome degradation. GO annotations related to this gene include ubiquitin-protein ligase activity and protein phosphatase binding.

UniProtKB/Swiss-Prot: APC4_HUMAN, Q9UJX5
Function: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin
ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by
mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of
'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked
polyubiquitin chains

Gene Wiki entry for ANAPC4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NT_006316.16  NC_018915.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ANAPC4 gene promoter:
         USF1   AML1a   POU3F1   Ik-3   MEF-2A   POU2F1   USF-1   POU2F1a   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ANAPC4 promoter sequence
   Search SABiosciences Chromatin IP Primers for ANAPC4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ANAPC4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p15.2   Ensembl cytogenetic band:  4p15.2   HGNC cytogenetic band: 4p15.31

ANAPC4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ANAPC4 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P025462:  view genomic region     (about GC identifiers)

Start:
25,378,835 bp from pter      End:
25,420,120 bp from pter
Size:
41,286 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: APC4_HUMAN, Q9UJX5 (See protein sequence)
Recommended Name: Anaphase-promoting complex subunit 4  
Size: 808 amino acids; 92116 Da
Subunit: The APC/C is composed of at least 12 subunits
Secondary accessions: A8K8H1 Q6PCC6 Q9NSH6
Alternative splicing: 2 isoforms:  Q9UJX5-1   Q9UJX5-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ANAPC4: NX_Q9UJX5

Explore proteomics data for ANAPC4 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9UJX5

  • ANAPC4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ANAPC4 Protein Expression
    REFSEQ proteins: NP_037499.2  
    ENSEMBL proteins: 
     ENSP00000318775   ENSP00000426654   ENSP00000426512   ENSP00000421840  
    Reactome Protein details: Q9UJX5
    Human Recombinant Protein Products for ANAPC4: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for ANAPC4
    GenScript Custom Purified and Recombinant Proteins Services for ANAPC4
    Novus Biologicals ANAPC4 Proteins
    Novus Biologicals ANAPC4 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ANAPC4 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005680anaphase-promoting complex IDA16364912
    GO:0005829cytosol TAS--

    ANAPC4 for ontologies           About GeneDecksing



    ANAPC4 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for ANAPC4
    GenScript Custom Superior Antibodies Services for ANAPC4
    Novus Biologicals ANAPC4 Antibodies
    Abcam antibodies for ANAPC4
    Cloud-Clone Corp. Antibodies for ANAPC4 
    ThermoFisher Antibodies for ANAPC4
    LSBio Antibodies in human, mouse, rat for ANAPC4 

    Assay Products for ANAPC4: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ANAPC4
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ANAPC4
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ANAPC4 
    Cloud-Clone Corp. CLIAs for ANAPC4


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ANAPC: Anaphase promoting complex subunits

    5/6 InterPro protein domains (see all 6):
     IPR024789 APC4
     IPR017986 WD40_repeat_dom
     IPR015943 WD40/YVTN_repeat-like_dom
     IPR017169 APC4_metazoa
     IPR024790 APC4_long_dom

    Graphical View of Domain Structure for InterPro Entry Q9UJX5

    ProtoNet protein and cluster: Q9UJX5

    UniProtKB/Swiss-Prot: APC4_HUMAN, Q9UJX5
    Similarity: Belongs to the APC4 family


    ANAPC4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: APC4_HUMAN, Q9UJX5
    Function: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin
    ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by
    mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of
    'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked
    polyubiquitin chains

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity TAS6180011
    GO:0005515protein binding IPI--
    GO:0019903protein phosphatase binding IPI--
         
    ANAPC4 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for ANAPC4:
     Increased ID2::GFP protein exp  Increased cell death in HCC-19  Synthetic lethal with Ras  Wnt reporter downregulated 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ANAPC4 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ANAPC4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ANAPC4 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ANAPC4 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ANAPC4
    1 QIAGEN miScript miRNA Assays for microRNA that regulate ANAPC4:
    hsa-miR-452
    SwitchGear 3'UTR luciferase reporter plasmidANAPC4 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ANAPC4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ANAPC4

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ANAPC4
    Sirion Biotech Customized adenovirus for overexpression of ANAPC4

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for ANAPC4 (see all 6)
    OriGene ORF clones in mouse, rat for ANAPC4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ANAPC4 (NM_013367)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ANAPC4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ANAPC4
    Sirion Biotech Customized lentivirus for stable overexpression of ANAPC4 
                         Customized lentivirus expression plasmids for stable overexpression of ANAPC4 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ANAPC4
    Search LifeMap BioReagents cell lines for ANAPC4
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANAPC4


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ANAPC4 About   (see all 22)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
    Mitotic Spindle Checkpoint0.95
    APC/C:Cdc20 mediated degradation of Cyclin B0.76
    Inactivation of APC/C via direct inhibition of the APC/C complex0.95
    Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase0.75
    Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components0.95
    Phosphorylation of the APC/C0.73
    APC-Cdc20 mediated degradation of Nek2A0.78
    Common schema of ubiquitination0.36
    2Antigen processing: Ubiquitination & Proteasome degradation
    Antigen processing: Ubiquitination & Proteasome degradation0.83
    Ubiquitin mediated proteolysis0.36
    Class I MHC mediated antigen processing & presentation0.83
    3CDK-mediated phosphorylation and removal of Cdc6
    APC/C:Cdc20 mediated degradation of mitotic proteins0.94
    Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins0.93
    Cdc20:Phospho-APC/C mediated degradation of Cyclin A0.94
    APC/C:Cdc20 mediated degradation of Securin0.93
    Regulation of APC/C activators between G1/S and early anaphase0.94
    APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G10.93
    APC/C-mediated degradation of cell cycle proteins0.94
    Autodegradation of Cdh1 by Cdh1:APC/C0.91
    4M Phase
    Mitotic Anaphase0.94
    M Phase0.88
    Separation of Sister Chromatids0.94
    Mitotic M-M/G1 phases0.88
    Mitotic Metaphase and Anaphase0.94
    5Cell Cycle
    Cell Cycle, Mitotic0.84
    Cell Cycle0.84

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/9 EMD Millipore Pathways for ANAPC4 (see all 9)
        Cell cycle Role of APC in cell cycle regulation
    Meiosis
    Cell cycle Regulation of G1/S transition (part 1)
    Development TGF-beta receptor signaling
    Signal transduction PKA signaling

    5/6 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for ANAPC4 (see all 6)
        Activation of PKA through GPCR
    Remodeling of Adherens Junctions
    cAMP Pathway
    CDC42 Pathway
    Mitotic Roles of Polo Like Kinases

    5/7 GeneGo (Thomson Reuters) Pathways for ANAPC4 (see all 7)
        Cell cycle Role of APC in cell cycle regulation
    G-protein signaling G-Protein alpha-s signaling cascades
    Signal transduction PKA signaling
    Cell cycle Regulation of G1/S transition (part 1)
    Cell cycle Spindle assembly and chromosome separation

    1 BioSystems Pathway for ANAPC4
        TGF-beta Receptor Signaling Pathway

    5/28        Reactome Pathways for ANAPC4 (see all 28)
        APC/C:Cdc20 mediated degradation of mitotic proteins
    Cell Cycle
    M Phase
    Phosphorylation of the APC/C
    Mitotic Spindle Checkpoint


    5         Kegg Pathways  (Kegg details for ANAPC4):
        Cell cycle
    Oocyte meiosis
    Ubiquitin mediated proteolysis
    Progesterone-mediated oocyte maturation
    HTLV-I infection

    UniProtKB/Swiss-Prot: APC4_HUMAN, Q9UJX5
    Pathway: Protein modification; protein ubiquitination


    ANAPC4 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ANAPC4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/105 Interacting proteins for ANAPC4 (Q9UJX52, 3 ENSP000003187754) via UniProtKB, MINT, STRING, and/or I2D (see all 105)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    NEK2P519552, ENSP000003559664MINT-8412949 MINT-8412968 MINT-8412937 MINT-8413199 MINT-8413025 MINT-8413062 STRING: ENSP00000355966
    BUB1BO605662, 3, ENSP000002875984MINT-8413231 MINT-8413199 MINT-8413062 I2D: score=2 STRING: ENSP00000287598
    ANAPC7Q9UJX32, 3, ENSP000003943944MINT-8413231 MINT-8413199 MINT-8413062 I2D: score=1 STRING: ENSP00000394394
    CDC20Q128342, 3, ENSP000003084504MINT-8413025 I2D: score=1 STRING: ENSP00000308450
    MAD2L1Q132572, ENSP000002965094MINT-8413199 MINT-8413025 STRING: ENSP00000296509
    About this table

    Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000086G2/M transition of mitotic cell cycle TAS9469815
    GO:0000090mitotic anaphase TAS9469815
    GO:0000278mitotic cell cycle TAS--
    GO:0006511ubiquitin-dependent protein catabolic process TAS9469815
    GO:0007067mitosis IEA--

    ANAPC4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ANAPC4 (APC4)

    Search CenterWatch for drugs/clinical trials and news about ANAPC4 / APC4

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ANAPC4 gene: 
    NM_013367.2  

    Unigene Cluster for ANAPC4:

    Anaphase promoting complex subunit 4
    Hs.152173  [show with all ESTs]
    Unigene Representative Sequence: AL353932
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000315368(uc003gro.3 uc003grp.3) ENST00000510092(uc010iet.1 uc010ieu.1)
    ENST00000505080 ENST00000505991 ENST00000507809 ENST00000507925 ENST00000503805
    ENST00000505842 ENST00000504256 ENST00000515848(uc003grq.3) ENST00000506973

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ANAPC4
    1 QIAGEN miScript miRNA Assays for microRNA that regulate ANAPC4:
    hsa-miR-452
    SwitchGear 3'UTR luciferase reporter plasmidANAPC4 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ANAPC4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ANAPC4
    Clone
    Products:
         
    OriGene clones in human, mouse for ANAPC4 (see all 6)
    OriGene ORF clones in mouse, rat for ANAPC4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ANAPC4 (NM_013367)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ANAPC4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ANAPC4
    Sirion Biotech Customized lentivirus for stable overexpression of ANAPC4 
                         Customized lentivirus expression plasmids for stable overexpression of ANAPC4 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for ANAPC4
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ANAPC4
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ANAPC4
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ANAPC4

    Additional mRNA sequence: 

    AF191338.1 AK001881.1 AK023562.1 AK023597.1 AK292336.1 AL353932.1 AY429517.1 AY429518.1 
    BC059383.1 

    11 DOTS entries:

    DT.420654  DT.95368421  DT.40191933  DT.87077450  DT.97841353  DT.86851252  DT.102836230  DT.121234270 
    DT.91705239  DT.99972970  DT.121234264 

    24/140 AceView cDNA sequences (see all 140):

    NM_013367 BM479644 CA975921 AA428784 BM683668 W73648 AI955406 AW583446 
    CA312572 BE883958 AI979163 BX956361 Z42287 AW583389 AI335868 AW583671 
    N63100 Z38516 BC059383 BM830490 BP337824 BQ632338 AI200120 BQ011691 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for ANAPC4 (see all 10)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b · 14c ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^
    SP1:                                                                                                        -           -                                       
    SP2:                                                                                                        -           -                                       
    SP3:                                                                                                                    -                                       
    SP4:                                                                                                                    -                                       
    SP5:                                                                                                                                                            

    ExUns: 20 ^ 21a · 21b ^ 22a · 22b ^ 23a · 23b ^ 24 ^ 25 ^ 26a · 26b ^ 27 ^ 28 ^ 29a · 29b · 29c
    SP1:                          -     -                             -                                 
    SP2:                          -     -                             -                                 
    SP3:                                                                                                
    SP4:                                                                                                
    SP5:                                                                                                


    ECgene alternative splicing isoforms for ANAPC4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ANAPC4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGAGAGTATT
    ANAPC4 Expression
    About this image


    See ANAPC4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ANAPC4

    SOURCE GeneReport for Unigene cluster: Hs.152173
        SABiosciences Expression via Pathway-Focused PCR Array including ANAPC4: 
              Ubiquitin Ligases in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for ANAPC4
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ANAPC4
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ANAPC4
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ANAPC4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANAPC4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ANAPC4 gene from 8/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Anapc41 , 5 anaphase promoting complex subunit 41, 5 87.77(n)1
    93.56(a)1
      5 (28.81 cM)5
    522061  NM_024213.21  NP_077175.11 
     528340155 
    chicken
    (Gallus gallus)
    Aves ANAPC41 anaphase promoting complex subunit 4 76.61(n)
    75.98(a)
      422805  XM_001231776.2  XP_001231777.1 
    lizard
    (Anolis carolinensis)
    Reptilia ANAPC46
    anaphase promoting complex subunit 4
    74(a)
    1 ↔ 1
    GL343348.1(198371-232301)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.37902 Transcribed sequence with weak similarity to protein more 78.87(n)    BX714840.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufa95b032 Transcribed sequence with weak similarity to protein more 74.13(n)    AL916167.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta APC41 Anaphase Promoting Complex 4 40.37(n)
    26.34(a)
      31835  NM_132294.3  NP_572522.2 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT4G215301 anaphase-promoting complex subunit 4 42.58(n)
    26.01(a)
      828238  NM_118273.7  NP_193884.6 
    rice
    (Oryza sativa)
    Liliopsida Os02g07859001 hypothetical protein 41.72(n)
    28.68(a)
      4330947  NM_001054866.2  NP_001048331.2 


    ENSEMBL Gene Tree for ANAPC4 (if available)
    TreeFam Gene Tree for ANAPC4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/968 SNPs in ANAPC4 are shown (see all 968)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0357924
    A colorectal cancer sample4--see VAR_0357922 I V mis40--------
    rs1451388221,2
    --25376927(+) GTTTAC/TGCCTC 1 -- us2k10--------
    rs1486614961,2
    C--25376937(+) CTGGGA/TACAGT 1 -- us2k10--------
    rs1892654721,2
    --25376962(+) GTATGC/GGTGTT 1 -- us2k10--------
    rs1421704631,2
    --25377177(+) GTTTGC/TGGCAA 1 -- us2k10--------
    rs3156821,2
    C,H--25377192(-) TTGCAA/GCCCTT 1 -- us2k117Minor allele frequency- G:0.12MN EA NA WA CSA 606
    rs1822142111,2
    --25377217(+) AGCAGC/GGTAGG 1 -- us2k10--------
    rs1872090381,2
    --25377227(+) GTATAA/GAGTCA 1 -- us2k10--------
    rs1910401751,2
    --25377388(+) TTTGAA/GCAAGT 1 -- us2k10--------
    rs1828663471,2
    --25377458(+) ATGGTA/GCTGTC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ANAPC4 (25378835 - 25420120 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for ANAPC4:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv509000CNV Insertion20534489

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing ANAPC4
    DNA2.0 Custom Variant and Variant Library Synthesis for ANAPC4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 606947    OMIM disorders: --

    2 diseases for ANAPC4:    About MalaCards
    cytomegalovirus infection    neuronitis


    ANAPC4 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ANAPC4

    Export disorders for ANAPC4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ANAPC4 gene, integrated from 9 sources (see all 60):
    (articles sorted by number of sources associating them with ANAPC4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a cullin homology region in a subunit of the anaphase-promoting complex. (PubMed id 9469815)1, 2, 9 Yu H.... Kirschner M.W. (1998)
    2. Genome-Wide Association Study of Anthropometric Trait s and Evidence of Interactions With Age and Study Year in Filipino Women. (PubMed id 20966902)1, 4 Croteau-Chonka D.C....Mohlke K.L. (2010)
    3. Mechanism of ubiquitin-chain formation by the human anaphase-promoting complex. (PubMed id 18485873)1, 2 Jin L....Rape M. (2008)
    4. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. (PubMed id 17554300)1, 4  . (2007)
    5. Localization of the coactivator Cdh1 and the cullin subunit Apc2 in a cryo-electron microscopy model of vertebrate APC/C. (PubMed id 16364912)1, 2 Dube P.... Stark H. (2005)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    7. Mitotic regulation of the human anaphase-promoting complex by phosphorylation. (PubMed id 14657031)1, 2 Kraft C....Peters J.-M. (2003)
    8. Two subgroups of HLA Bw44 defined by cell-mediated lympholysis that differ in Bw44 expression on platelets and in patterns of genetic linkage disequilibrium. (PubMed id 6180011)1, 3 Tekolf W.A....Shaw S. (1982)
    9. The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells. (PubMed id 23667531)1 Cox J.L....Rizzino A. (2013)
    10. Transcriptional intermediary factor 1g binds to the an aphase-promoting complex/cyclosome and promotes mitosis. (PubMed id 23160376)1 Sedgwick G.G....Turnell A.S. (2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 29945 HGNC: 19990 AceView: ANAPC4 Ensembl:ENSG00000053900 euGenes: HUgn29945
    ECgene: ANAPC4 Kegg: 29945 H-InvDB: ANAPC4

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ANAPC4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ANAPC4 gene:
    Search GeneIP for patents involving ANAPC4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for ANAPC4  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for ANAPC4  
     OriGene qSTAR qPCR primer pairs in human, mouse for ANAPC4   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for ANAPC4   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ANAPC4   OriGene Custom Protein Services for ANAPC4  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ANAPC4
     QIAGEN SeqTarget long-range PCR primers for resequencing ANAPC4
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ANAPC4
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ANAPC4
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ANAPC4
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ANAPC4
     GenScript Custom Purified and Recombinant Proteins Services for ANAPC4 GenScript cDNA clones with any tag delivered in your preferred vector for ANAPC4
     GenScript Custom Assay Services for ANAPC4 GenScript Custom Superior Antibodies Services for ANAPC4
     GenScript Custom overexpressing Cell Line Services for ANAPC4 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in ANAPC4 promoter
     Search Chromatin IP Primers for ANAPC4
     RT2 qPCR Primer Assay in human, mouse, rat ANAPC4
     Search GNC Networks for ANAPC4
     SABiosciences PCR Arrays including human, mouse, rat ANAPC4
     Search Tocris compounds for ANAPC4 (APC4)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     ANAPC4 antibodies
     ANAPC4 proteins
     ANAPC4 lysates
     Antibodies for ANAPC4
     See all of Abcam's Antibodies, Kits and Proteins for ANAPC4
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for ANAPC4
     Antibodies for ANAPC4
     ELISAs for ANAPC4
     CLIAs for ANAPC4
     Search LifeMap BioReagents cell lines for ANAPC4
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANAPC4
     SwitchGear 3'UTR luciferase reporter plasmids for ANAPC4
     SwitchGear Promoter luciferase reporter plasmids for ANAPC4
     ThermoFisher Antibodies for ANAPC4
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ANAPC4
     inGenious Targeting Laboratory - Custom generated mouse model solutions for ANAPC4
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ANAPC4
    Customized:
     lentivirus for stable overexpression of ANAPC4
     lentivirus expression plasmids for stable overexpression of ANAPC4
     adenovirus for overexpression of ANAPC4
     LSBio Antibodies in human, mouse, rat for ANAPC4
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      ANAPC4 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4