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Aliases for ANAPC2 Gene

Aliases for ANAPC2 Gene

  • Anaphase Promoting Complex Subunit 2 2 3 5
  • Cyclosome Subunit 2 3 4
  • APC2 3 4
  • Anaphase-Promoting Complex Subunit 2 3
  • KIAA1406 4

External Ids for ANAPC2 Gene

Previous GeneCards Identifiers for ANAPC2 Gene

  • GC09M131759
  • GC09M133510
  • GC09M135426
  • GC09M137345
  • GC09M139189
  • GC09M140069
  • GC09M109530

Summaries for ANAPC2 Gene

Entrez Gene Summary for ANAPC2 Gene

  • A large protein complex, termed the anaphase-promoting complex (APC), or the cyclosome, promotes metaphase-anaphase transition by ubiquitinating its specific substrates such as mitotic cyclins and anaphase inhibitor, which are subsequently degraded by the 26S proteasome. Biochemical studies have shown that the vertebrate APC contains eight subunits. The composition of the APC is highly conserved in organisms from yeast to humans. The product of this gene is a component of the complex and shares sequence similarity with a recently identified family of proteins called cullins, which may also be involved in ubiquitin-mediated degradation. [provided by RefSeq, Jul 2008]

GeneCards Summary for ANAPC2 Gene

ANAPC2 (Anaphase Promoting Complex Subunit 2) is a Protein Coding gene. Among its related pathways are G-protein signaling G-Protein alpha-i signaling cascades and APC-Cdc20 mediated degradation of Nek2A. GO annotations related to this gene include ubiquitin protein ligase binding.

UniProtKB/Swiss-Prot for ANAPC2 Gene

  • Together with the RING-H2 protein ANAPC11, constitutes the catalytic component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of Lys-11-linked polyubiquitin chains and, to a lower extent, the formation of Lys-48- and Lys-63-linked polyubiquitin chains. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 drives presynaptic differentiation.

Gene Wiki entry for ANAPC2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANAPC2 Gene

Genomics for ANAPC2 Gene

Regulatory Elements for ANAPC2 Gene

Enhancers for ANAPC2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09G136563 2.4 VISTA FANTOM5 Ensembl ENCODE dbSUPER 11.3 +620.1 620063 10.7 HDGF FOXA2 MLX WRNIP1 ARID4B SIN3A YBX1 ZBTB7B SLC30A9 ZNF143 NOTCH1 SNAPC4 ANAPC2 CCDC183-AS1 SEC16A FUT7 TMEM250 NACC2 MIR4674 LINC01451
GH09G136398 1.6 FANTOM5 ENCODE dbSUPER 15.7 +788.8 788784 3.0 HDGF CREB3L1 AGO1 ARID4B SIN3A ZNF766 ZNF207 ZNF143 DEK REST INPP5E DNLZ SNAPC4 ANAPC2 SNHG7 CARD9 SEC16A NDOR1 FAM69B TRAF2
GH09G136990 1.7 FANTOM5 Ensembl ENCODE 14.2 +192.6 192590 10.9 HDGF PKNOX1 CREB3L1 ARNT AGO1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 LCN12 ABCA2 ANAPC2 PRR31 C9orf139 SNHG7 LCNL1 RABL6 CCDC183 LOC100418938
GH09G136613 2 FANTOM5 Ensembl ENCODE dbSUPER 11.3 +567.7 567744 14.5 HDGF PKNOX1 FOXA2 MLX AGO1 ZFP64 SIN3A ARID4B DMAP1 YY1 DPH7 ARRDC1-AS1 SNAPC4 ANAPC2 NOTCH1 CCDC183-AS1 FUT7 EGFL7 SEC16A ABCA2
GH09G136266 1.5 Ensembl ENCODE dbSUPER 14.2 +920.7 920656 2.3 HDGF PKNOX1 ARNT ARID4B GLI4 ZNF121 GTF3C2 ZNF207 ZNF143 KLF7 ANAPC2 GPSM1 SNHG7 LHX3 NDOR1 LOC101928722 CCDC187
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ANAPC2 on UCSC Golden Path with GeneCards custom track

Genomic Location for ANAPC2 Gene

Chromosome:
9
Start:
137,174,784 bp from pter
End:
137,188,605 bp from pter
Size:
13,822 bases
Orientation:
Minus strand

Genomic View for ANAPC2 Gene

Genes around ANAPC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANAPC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANAPC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANAPC2 Gene

Proteins for ANAPC2 Gene

  • Protein details for ANAPC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UJX6-ANC2_HUMAN
    Recommended name:
    Anaphase-promoting complex subunit 2
    Protein Accession:
    Q9UJX6
    Secondary Accessions:
    • Q5VSG1
    • Q96DG5
    • Q96GG4
    • Q9P2E1

    Protein attributes for ANAPC2 Gene

    Size:
    822 amino acids
    Molecular mass:
    93828 Da
    Quaternary structure:
    • Interacts with NEUROD2 (By similarity). The mammalian APC/C is composed of 14 distinct subunits that assemble into a complex of at least 19 chains with a combined molecular mass of around 1.2 MDa. Interacts through the cullin domain with ANAPC11 and with UBCH10.
    SequenceCaution:
    • Sequence=AAH09487.2; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ANAPC2 Gene

    Alternative splice isoforms for ANAPC2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ANAPC2 Gene

Post-translational modifications for ANAPC2 Gene

  • Ubiquitination at posLast=134134, Lys190, and Lys228
  • Modification sites at PhosphoSitePlus

Other Protein References for ANAPC2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for ANAPC2 (APC2)
  • Abcam antibodies for ANAPC2
  • Santa Cruz Biotechnology (SCBT) Antibodies for ANAPC2

No data available for DME Specific Peptides for ANAPC2 Gene

Domains & Families for ANAPC2 Gene

Gene Families for ANAPC2 Gene

Protein Domains for ANAPC2 Gene

Suggested Antigen Peptide Sequences for ANAPC2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UJX6

UniProtKB/Swiss-Prot:

ANC2_HUMAN :
  • Belongs to the cullin family.
Family:
  • Belongs to the cullin family.
genes like me logo Genes that share domains with ANAPC2: view

Function for ANAPC2 Gene

Molecular function for ANAPC2 Gene

UniProtKB/Swiss-Prot Function:
Together with the RING-H2 protein ANAPC11, constitutes the catalytic component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of Lys-11-linked polyubiquitin chains and, to a lower extent, the formation of Lys-48- and Lys-63-linked polyubiquitin chains. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 drives presynaptic differentiation.

Gene Ontology (GO) - Molecular Function for ANAPC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031625 ubiquitin protein ligase binding IBA --
GO:0061630 contributes_to ubiquitin protein ligase activity IBA --
genes like me logo Genes that share ontologies with ANAPC2: view
genes like me logo Genes that share phenotypes with ANAPC2: view

Animal Models for ANAPC2 Gene

MGI Knock Outs for ANAPC2:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ANAPC2 Gene

Localization for ANAPC2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ANAPC2 gene
Compartment Confidence
nucleus 5
cytosol 5
mitochondrion 1

Gene Ontology (GO) - Cellular Components for ANAPC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0005680 anaphase-promoting complex IDA 16364912
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with ANAPC2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ANAPC2 Gene

Pathways & Interactions for ANAPC2 Gene

SuperPathways for ANAPC2 Gene

SuperPathway Contained pathways
1 CDK-mediated phosphorylation and removal of Cdc6
2 APC-Cdc20 mediated degradation of Nek2A
3 Class I MHC mediated antigen processing and presentation
4 Cell Cycle, Mitotic
.60
5 Cellular Senescence
genes like me logo Genes that share pathways with ANAPC2: view

UniProtKB/Swiss-Prot Q9UJX6-ANC2_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

SIGNOR curated interactions for ANAPC2 Gene

Inactivates:

Gene Ontology (GO) - Biological Process for ANAPC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006511 ubiquitin-dependent protein catabolic process IEA --
GO:0007049 cell cycle IEA --
GO:0007067 mitotic nuclear division IEA --
GO:0007399 nervous system development IEA --
GO:0016567 protein ubiquitination IEA --
genes like me logo Genes that share ontologies with ANAPC2: view

Transcripts for ANAPC2 Gene

Unigene Clusters for ANAPC2 Gene

Anaphase promoting complex subunit 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ANAPC2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12a · 12b ^ 13a · 13b · 13c ^ 14
SP1: - -
SP2: - -
SP3:
SP4: -
SP5: - -
SP6:
SP7:

Relevant External Links for ANAPC2 Gene

GeneLoc Exon Structure for
ANAPC2
ECgene alternative splicing isoforms for
ANAPC2

Expression for ANAPC2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ANAPC2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ANAPC2 Gene

This gene is overexpressed in Bone (50.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ANAPC2 Gene



NURSA nuclear receptor signaling pathways regulating expression of ANAPC2 Gene:

ANAPC2

SOURCE GeneReport for Unigene cluster for ANAPC2 Gene:

Hs.533262

Evidence on tissue expression from TISSUES for ANAPC2 Gene

  • Nervous system(4.4)
  • Liver(4.3)
  • Stomach(2.1)
genes like me logo Genes that share expression patterns with ANAPC2: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ANAPC2 Gene

Orthologs for ANAPC2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ANAPC2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ANAPC2 34 35
  • 96.3 (n)
cow
(Bos Taurus)
Mammalia -- 35
  • 94 (a)
OneToMany
-- 35
  • 86 (a)
OneToMany
dog
(Canis familiaris)
Mammalia ANAPC2 34
  • 89.45 (n)
rat
(Rattus norvegicus)
Mammalia Anapc2 34
  • 86.48 (n)
mouse
(Mus musculus)
Mammalia Anapc2 34 16 35
  • 85.95 (n)
oppossum
(Monodelphis domestica)
Mammalia ANAPC2 35
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ANAPC2 35
  • 52 (a)
OneToOne
chicken
(Gallus gallus)
Aves ANAPC2 34 35
  • 75.93 (n)
lizard
(Anolis carolinensis)
Reptilia ANAPC2 35
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia anapc2 34
  • 69.08 (n)
Str.15442 34
zebrafish
(Danio rerio)
Actinopterygii anapc2 34 35
  • 61.22 (n)
fruit fly
(Drosophila melanogaster)
Insecta mr 34 35
  • 50.98 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005048 34
  • 50.69 (n)
worm
(Caenorhabditis elegans)
Secernentea apc-2 35
  • 24 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes APC2 35 37
  • 18 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons APC2 34
  • 48.19 (n)
rice
(Oryza sativa)
Liliopsida Os04g0484800 34
  • 48.65 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 29 (a)
OneToOne
Species where no ortholog for ANAPC2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ANAPC2 Gene

ENSEMBL:
Gene Tree for ANAPC2 (if available)
TreeFam:
Gene Tree for ANAPC2 (if available)

Paralogs for ANAPC2 Gene

No data available for Paralogs for ANAPC2 Gene

Variants for ANAPC2 Gene

Sequence variations from dbSNP and Humsavar for ANAPC2 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1000143800 -- 137,182,079(+) AAGGC(C/T)GGCCT intron-variant
rs1000219495 -- 137,185,489(+) CGCCG(C/T)GGGGC intron-variant
rs1000250402 -- 137,185,697(+) CAGGA(C/T)GGGGG intron-variant
rs1000254588 -- 137,175,320(+) GTTGT(C/T)CCGGT nc-transcript-variant, reference, missense
rs1000352600 -- 137,183,401(+) GTTCA(C/T)AGGTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ANAPC2 Gene

Variant ID Type Subtype PubMed ID
dgv13009n54 CNV loss 21841781
esv2422220 CNV deletion 17116639
esv2761561 CNV gain 21179565
nsv1161918 CNV duplication 26073780
nsv524322 CNV loss 19592680
nsv616007 CNV loss 21841781
nsv951207 CNV deletion 24416366

Variation tolerance for ANAPC2 Gene

Residual Variation Intolerance Score: 6.48% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.78; 33.56% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ANAPC2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ANAPC2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANAPC2 Gene

Disorders for ANAPC2 Gene

Relevant External Links for ANAPC2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ANAPC2

No disorders were found for ANAPC2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANAPC2 Gene

Publications for ANAPC2 Gene

  1. APC2 cullin protein and APC11 RING protein comprise the minimal ubiquitin ligase module of the anaphase-promoting complex. (PMID: 11739784) Tang Z. … Yu H. (Mol. Biol. Cell 2001) 2 3 4 64
  2. Identification of a cullin homology region in a subunit of the anaphase-promoting complex. (PMID: 9469815) Yu H. … Kirschner M.W. (Science 1998) 3 4 22 64
  3. Molecular architecture and mechanism of the anaphase-promoting complex. (PMID: 25043029) Chang L. … Barford D. (Nature 2014) 3 4 64
  4. Mechanism of ubiquitin-chain formation by the human anaphase- promoting complex. (PMID: 18485873) Jin L. … Rape M. (Cell 2008) 3 4 64
  5. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil S.A. … Gygi S.P. (Nat. Biotechnol. 2006) 3 4 64

Products for ANAPC2 Gene

Sources for ANAPC2 Gene

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