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Aliases for ANAPC2 Gene

Aliases for ANAPC2 Gene

  • Anaphase Promoting Complex Subunit 2 2 3 5
  • Cyclosome Subunit 2 3 4
  • APC2 3 4
  • KIAA1406 4

External Ids for ANAPC2 Gene

Previous GeneCards Identifiers for ANAPC2 Gene

  • GC09M131759
  • GC09M133510
  • GC09M135426
  • GC09M137345
  • GC09M139189
  • GC09M140069
  • GC09M109530

Summaries for ANAPC2 Gene

Entrez Gene Summary for ANAPC2 Gene

  • A large protein complex, termed the anaphase-promoting complex (APC), or the cyclosome, promotes metaphase-anaphase transition by ubiquitinating its specific substrates such as mitotic cyclins and anaphase inhibitor, which are subsequently degraded by the 26S proteasome. Biochemical studies have shown that the vertebrate APC contains eight subunits. The composition of the APC is highly conserved in organisms from yeast to humans. The product of this gene is a component of the complex and shares sequence similarity with a recently identified family of proteins called cullins, which may also be involved in ubiquitin-mediated degradation. [provided by RefSeq, Jul 2008]

GeneCards Summary for ANAPC2 Gene

ANAPC2 (Anaphase Promoting Complex Subunit 2) is a Protein Coding gene. Among its related pathways are Cell cycle and HTLV-I infection. GO annotations related to this gene include ubiquitin protein ligase binding.

UniProtKB/Swiss-Prot for ANAPC2 Gene

  • Together with the RING-H2 protein ANAPC11, constitutes the catalytic component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of Lys-11-linked polyubiquitin chains and, to a lower extent, the formation of Lys-48- and Lys-63-linked polyubiquitin chains. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 drives presynaptic differentiation.

Gene Wiki entry for ANAPC2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANAPC2 Gene

Genomics for ANAPC2 Gene

Regulatory Elements for ANAPC2 Gene

Enhancers for ANAPC2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ANAPC2 on UCSC Golden Path with GeneCards custom track

Promoters for ANAPC2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ANAPC2 on UCSC Golden Path with GeneCards custom track

Genomic Location for ANAPC2 Gene

Chromosome:
9
Start:
137,174,784 bp from pter
End:
137,188,605 bp from pter
Size:
13,822 bases
Orientation:
Minus strand

Genomic View for ANAPC2 Gene

Genes around ANAPC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANAPC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANAPC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANAPC2 Gene

Proteins for ANAPC2 Gene

  • Protein details for ANAPC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UJX6-ANC2_HUMAN
    Recommended name:
    Anaphase-promoting complex subunit 2
    Protein Accession:
    Q9UJX6
    Secondary Accessions:
    • Q5VSG1
    • Q96DG5
    • Q96GG4
    • Q9P2E1

    Protein attributes for ANAPC2 Gene

    Size:
    822 amino acids
    Molecular mass:
    93828 Da
    Quaternary structure:
    • Interacts with NEUROD2 (By similarity). The mammalian APC/C is composed of 14 distinct subunits that assemble into a complex of at least 19 chains with a combined molecular mass of around 1.2 MDa. Interacts through the cullin domain with ANAPC11 and with UBCH10.
    SequenceCaution:
    • Sequence=AAH09487.2; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ANAPC2 Gene

    Alternative splice isoforms for ANAPC2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ANAPC2 Gene

Proteomics data for ANAPC2 Gene at MOPED

Post-translational modifications for ANAPC2 Gene

  • Ubiquitination at Lys 134, Lys 190, and Lys 228
  • Modification sites at PhosphoSitePlus

Other Protein References for ANAPC2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for ANAPC2 (APC2)

No data available for DME Specific Peptides for ANAPC2 Gene

Domains & Families for ANAPC2 Gene

Gene Families for ANAPC2 Gene

Protein Domains for ANAPC2 Gene

Suggested Antigen Peptide Sequences for ANAPC2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UJX6

UniProtKB/Swiss-Prot:

ANC2_HUMAN :
  • Belongs to the cullin family.
Family:
  • Belongs to the cullin family.
genes like me logo Genes that share domains with ANAPC2: view

Function for ANAPC2 Gene

Molecular function for ANAPC2 Gene

UniProtKB/Swiss-Prot Function:
Together with the RING-H2 protein ANAPC11, constitutes the catalytic component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of Lys-11-linked polyubiquitin chains and, to a lower extent, the formation of Lys-48- and Lys-63-linked polyubiquitin chains. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 drives presynaptic differentiation.
genes like me logo Genes that share phenotypes with ANAPC2: view

Animal Models for ANAPC2 Gene

MGI Knock Outs for ANAPC2:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ANAPC2 Gene

Localization for ANAPC2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ANAPC2 Gene COMPARTMENTS Subcellular localization image for ANAPC2 gene
Compartment Confidence
cytosol 5
nucleus 5
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ANAPC2 Gene

Pathways & Interactions for ANAPC2 Gene

SuperPathways for ANAPC2 Gene

Superpath Contained pathways
1 CDK-mediated phosphorylation and removal of Cdc6
2 APC-Cdc20 mediated degradation of Nek2A
3 Antigen processing- Ubiquitination and Proteasome degradation
4 Cell Cycle, Mitotic
.61
5 Cellular Senescence
genes like me logo Genes that share pathways with ANAPC2: view

UniProtKB/Swiss-Prot Q9UJX6-ANC2_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

SIGNOR curated interactions for ANAPC2 Gene

Inactivates:

Gene Ontology (GO) - Biological Process for ANAPC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006511 ubiquitin-dependent protein catabolic process IEA --
GO:0007067 mitotic nuclear division IEA --
GO:0007094 mitotic spindle assembly checkpoint TAS --
GO:0031145 anaphase-promoting complex-dependent catabolic process TAS --
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process TAS --
genes like me logo Genes that share ontologies with ANAPC2: view

Drugs & Compounds for ANAPC2 Gene

No Compound Related Data Available

Transcripts for ANAPC2 Gene

Unigene Clusters for ANAPC2 Gene

Anaphase promoting complex subunit 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ANAPC2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12a · 12b ^ 13a · 13b · 13c ^ 14
SP1: - -
SP2: - -
SP3:
SP4: -
SP5: - -
SP6:
SP7:

Relevant External Links for ANAPC2 Gene

GeneLoc Exon Structure for
ANAPC2
ECgene alternative splicing isoforms for
ANAPC2

Expression for ANAPC2 Gene

mRNA expression in normal human tissues for ANAPC2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ANAPC2 Gene

This gene is overexpressed in Bone (50.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ANAPC2 Gene



SOURCE GeneReport for Unigene cluster for ANAPC2 Gene Hs.533262

genes like me logo Genes that share expression patterns with ANAPC2: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for ANAPC2 Gene

Orthologs for ANAPC2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ANAPC2 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia ANAPC2 35
  • 89.45 (n)
  • 95.35 (a)
mouse
(Mus musculus)
Mammalia Anapc2 35
  • 85.95 (n)
  • 94.52 (a)
Anapc2 16
Anapc2 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ANAPC2 35
  • 96.3 (n)
  • 95.52 (a)
ANAPC2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Anapc2 35
  • 86.48 (n)
  • 94.88 (a)
cow
(Bos Taurus)
Mammalia -- 36
  • 94 (a)
OneToMany
-- 36
  • 86 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia ANAPC2 36
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ANAPC2 36
  • 52 (a)
OneToOne
chicken
(Gallus gallus)
Aves ANAPC2 35
  • 75.93 (n)
  • 72.09 (a)
ANAPC2 36
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ANAPC2 36
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia anapc2 35
  • 69.08 (n)
  • 68.03 (a)
Str.15442 35
zebrafish
(Danio rerio)
Actinopterygii anapc2 35
  • 61.22 (n)
  • 57.53 (a)
anapc2 36
  • 55 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005048 35
  • 50.69 (n)
  • 39.42 (a)
fruit fly
(Drosophila melanogaster)
Insecta mr 35
  • 50.98 (n)
  • 41.02 (a)
mr 36
  • 36 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea apc-2 36
  • 24 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes APC2 36
  • 18 (a)
OneToOne
APC2 38
thale cress
(Arabidopsis thaliana)
eudicotyledons APC2 35
  • 48.19 (n)
  • 40.04 (a)
rice
(Oryza sativa)
Liliopsida Os04g0484800 35
  • 48.65 (n)
  • 43 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 29 (a)
OneToOne
Species with no ortholog for ANAPC2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ANAPC2 Gene

ENSEMBL:
Gene Tree for ANAPC2 (if available)
TreeFam:
Gene Tree for ANAPC2 (if available)

Paralogs for ANAPC2 Gene

No data available for Paralogs for ANAPC2 Gene

Variants for ANAPC2 Gene

Sequence variations from dbSNP and Humsavar for ANAPC2 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs112995447 -- 137,185,585(+) GCCCA(C/T)CGCTT intron-variant
rs113007355 -- 137,177,168(+) CACCC(A/G)CAGAA intron-variant
rs113328938 -- 137,176,947(+) TTGGG(A/G)ATCTG intron-variant
rs113517964 -- 137,180,041(+) TCTCC(C/T)GCAGA intron-variant
rs113622816 -- 137,184,010(+) GCCAG(C/T)CCCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ANAPC2 Gene

Variant ID Type Subtype PubMed ID
nsv894387 CNV Gain 21882294
esv2422220 CNV Deletion 17116639
dgv8412n71 CNV Loss 21882294
dgv8416n71 CNV Loss 21882294
nsv524322 CNV Loss 19592680
nsv894469 CNV Loss 21882294
dgv8423n71 CNV Loss 21882294
nsv894502 CNV Loss 21882294
nsv894506 CNV Gain 21882294
dgv8428n71 CNV Loss 21882294
nsv894521 CNV Loss 21882294
dgv8437n71 CNV Gain 21882294
dgv8439n71 CNV Loss 21882294
dgv8441n71 CNV Loss 21882294
dgv8442n71 CNV Loss 21882294
dgv8445n71 CNV Loss 21882294
dgv8446n71 CNV Loss 21882294
dgv8447n71 CNV Loss 21882294
dgv8450n71 CNV Loss 21882294
nsv894603 CNV Gain+Loss 21882294
dgv8451n71 CNV Loss 21882294
dgv8452n71 CNV Gain+Loss 21882294
dgv8453n71 CNV Gain 21882294
dgv8454n71 CNV Gain 21882294
dgv8455n71 CNV Gain+Loss 21882294

Variation tolerance for ANAPC2 Gene

Residual Variation Intolerance Score: 6.48% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.78; 33.56% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ANAPC2 Gene

HapMap Linkage Disequilibrium report
ANAPC2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANAPC2 Gene

Disorders for ANAPC2 Gene

Relevant External Links for ANAPC2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ANAPC2

No disorders were found for ANAPC2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANAPC2 Gene

Publications for ANAPC2 Gene

  1. APC2 cullin protein and APC11 RING protein comprise the minimal ubiquitin ligase module of the anaphase-promoting complex. (PMID: 11739784) Tang Z. … Yu H. (Mol. Biol. Cell 2001) 2 3 4 67
  2. Identification of a cullin homology region in a subunit of the anaphase-promoting complex. (PMID: 9469815) Yu H. … Kirschner M.W. (Science 1998) 3 23
  3. Structure of an APC3-APC16 complex: insights into assembly of the anaphase-promoting complex/cyclosome. (PMID: 25490258) Yamaguchi M. … Schulman B.A. (J. Mol. Biol. 2015) 3
  4. Nek2A destruction marks APC/C activation at the prophase-to-prometaphase transition by spindle-checkpoint-restricted Cdc20. (PMID: 25673878) Boekhout M. … Wolthuis R. (J. Cell. Sci. 2015) 3
  5. RING E3 mechanism for ubiquitin ligation to a disordered substrate visualized for human anaphase-promoting complex. (PMID: 25825779) Brown N.G. … Schulman B.A. (Proc. Natl. Acad. Sci. U.S.A. 2015) 3

Products for ANAPC2 Gene

Sources for ANAPC2 Gene

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