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ANAPC2 Gene

protein-coding   GIFtS: 59
GCID: GC09M140069

Anaphase Promoting Complex Subunit 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Anaphase Promoting Complex Subunit 21 2
APC22 3 5
Cyclosome Subunit 22 3
KIAA14063 5
Anaphase-Promoting Complex Subunit 22

External Ids:    HGNC: 199891   Entrez Gene: 298822   Ensembl: ENSG000001762487   OMIM: 6069465   UniProtKB: Q9UJX63   

Export aliases for ANAPC2 gene to outside databases

Previous GC identifers: GC09M131759 GC09M133510 GC09M135426 GC09M137345 GC09M139189 GC09M109530


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ANAPC2 Gene:
A large protein complex, termed the anaphase-promoting complex (APC), or the cyclosome, promotes
metaphase-anaphase transition by ubiquitinating its specific substrates such as mitotic cyclins and anaphase
inhibitor, which are subsequently degraded by the 26S proteasome. Biochemical studies have shown that the
vertebrate APC contains eight subunits. The composition of the APC is highly conserved in organisms from yeast to
humans. The product of this gene is a component of the complex and shares sequence similarity with a recently
identified family of proteins called cullins, which may also be involved in ubiquitin-mediated degradation.
(provided by RefSeq, Jul 2008)

GeneCards Summary for ANAPC2 Gene:
ANAPC2 (anaphase promoting complex subunit 2) is a protein-coding gene. Diseases associated with ANAPC2 include brain cancer, and retinoblastoma. GO annotations related to this gene include ubiquitin-protein ligase activity and ubiquitin protein ligase binding.

UniProtKB/Swiss-Prot: ANC2_HUMAN, Q9UJX6
Function: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin
ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by
mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of
'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked
polyubiquitin chains. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering
at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2
drives presynaptic differentiation

Gene Wiki entry for ANAPC2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000009.12  NC_018920.2  NT_008470.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the ANAPC2 gene promoter:
         CREB   deltaCREB   MyoD   Nkx2-5   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidANAPC2 promoter sequence
   Search Chromatin IP Primers for ANAPC2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ANAPC2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q34.3   Ensembl cytogenetic band:  9q34.3   HGNC cytogenetic band: 9q34.3

ANAPC2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ANAPC2 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M140069:  view genomic region     (about GC identifiers)

Start:
140,069,236 bp from pter      End:
140,083,057 bp from pter
Size:
13,822 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ANC2_HUMAN, Q9UJX6 (See protein sequence)
Recommended Name: Anaphase-promoting complex subunit 2  
Size: 822 amino acids; 93828 Da
Subunit: Interacts with NEUROD2 (By similarity). The APC/C is composed of at least 12 subunits. Interacts through
the cullin domain with ANAPC11 and with UBCH10
Sequence caution: Sequence=AAH09487.2; Type=Erroneous translation; Note=Wrong choice of frame;
Secondary accessions: Q5VSG1 Q96DG5 Q96GG4 Q9P2E1
Alternative splicing: 2 isoforms:  Q9UJX6-1   Q9UJX6-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ANAPC2: NX_Q9UJX6

Explore proteomics data for ANAPC2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys134, Lys190, Lys228
  • Modification sites at PhosphoSitePlus

  • See ANAPC2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_037498.1  
    ENSEMBL proteins: 
     ENSP00000314004  
    Reactome Protein details: Q9UJX6

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ANAPC: Anaphase promoting complex subunits

    4 InterPro protein domains:
     IPR001373 Cullin_N
     IPR011991 WHTH_DNA-bd_dom
     IPR016158 Cullin_homology
     IPR014786 APC_su2_C

    Graphical View of Domain Structure for InterPro Entry Q9UJX6

    ProtoNet protein and cluster: Q9UJX6

    UniProtKB/Swiss-Prot: ANC2_HUMAN, Q9UJX6
    Similarity: Belongs to the cullin family


    ANAPC2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ANC2_HUMAN, Q9UJX6
    Function: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin
    ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by
    mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of
    'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked
    polyubiquitin chains. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering
    at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2
    drives presynaptic differentiation

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity TAS9469815
    GO:0031625ubiquitin protein ligase binding IEA--
         
    ANAPC2 for ontologies           About GeneDecksing


    Phenotypes:
         6 GenomeRNAi human phenotypes for ANAPC2:
     Decreased viability of wild-ty  Increased cell death in DLD-1   Increased cell death in breast  Increased cell number in S 
     Synthetic lethal with Ras  Upregulation of Wnt/beta-caten 

         7 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Anapc2):
     cellular  hematopoietic system  homeostasis/metabolism  liver/biliary system  mortality/aging 
     normal  skeleton 

    ANAPC2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Anapc2tm2Kna for ANAPC2

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    mitochondrion1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005654nucleoplasm TAS--
    GO:0005680anaphase-promoting complex IDA16364912
    GO:0005829cytosol TAS--
    GO:0031461cullin-RING ubiquitin ligase complex ----

    ANAPC2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ANAPC2 About   (see all 24)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Inactivation of APC/C via direct inhibition of the APC/C complex
    Inactivation of APC/C via direct inhibition of the APC/C complex0.64
    Mitotic Spindle Checkpoint0.62
    APC/C-Cdc20 mediated degradation of Cyclin B0.64
    Common schema of ubiquitination0.33
    Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components0.64
    2Class I MHC mediated antigen processing and presentation
    Class I MHC mediated antigen processing and presentation0.84
    Adaptive Immune System0.41
    Antigen processing- Ubiquitination and Proteasome degradation0.84
    Ubiquitin mediated proteolysis0.35
    3CDK-mediated phosphorylation and removal of Cdc6
    APC/C-mediated degradation of cell cycle proteins0.94
    Activation of APC/C and APC/C-Cdc20 mediated degradation of mitotic proteins0.92
    Regulation of mitotic cell cycle0.94
    Autodegradation of Cdh1 by Cdh1-APC/C0.91
    Regulation of APC/C activators between G1/S and early anaphase0.94
    Cell Cycle Checkpoints0.58
    APC/C-Cdc20 mediated degradation of Securin0.93
    Phosphorylation of the APC/C0.00
    4Mitotic Metaphase and Anaphase
    Mitotic Anaphase0.94
    Mitotic Metaphase and Anaphase0.93
    Separation of Sister Chromatids0.94
    5Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    M Phase0.62
    Cell Cycle0.90

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for ANAPC2 (see all 6)
        Activation of PKA through GPCR
    Remodeling of Adherens Junctions
    cAMP Pathway
    CDC42 Pathway
    Mitotic Roles of Polo Like Kinases

    2 Cell Signaling Technology (CST) Pathways for ANAPC2
        Cell Cycle / Checkpoint Control
    Protein Stability

    Selected GeneGo (Thomson Reuters) Pathways for ANAPC2 (see all 7)
        Cell cycle Role of APC in cell cycle regulation
    G-protein signaling G-Protein alpha-s signaling cascades
    Signal transduction PKA signaling
    Cell cycle Regulation of G1/S transition (part 1)
    Cell cycle Spindle assembly and chromosome separation

    1 BioSystems Pathway for ANAPC2
        TGF-beta Receptor Signaling Pathway


    Selected Reactome Pathways for ANAPC2 (see all 12)
        APC/C:Cdc20 mediated degradation of mitotic proteins
    Autodegradation of Cdh1 by Cdh1:APC/C
    Phosphorylation of the APC/C
    Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
    APC/C:Cdc20 mediated degradation of Securin


    5 Kegg Pathways  (Kegg details for ANAPC2):
        Cell cycle
    Oocyte meiosis
    Ubiquitin mediated proteolysis
    Progesterone-mediated oocyte maturation
    HTLV-I infection

    UniProtKB/Swiss-Prot: ANC2_HUMAN, Q9UJX6
    Pathway: Protein modification; protein ubiquitination


    ANAPC2 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ANAPC2: 

              Ubiquitination (Ubiquitylation) Pathway in human mouse rat
              Cell Cycle in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for ANAPC2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ANAPC2 (Q9UJX62, 3 ENSP000003140044) via UniProtKB, MINT, STRING, and/or I2D (see all 679)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDC16Q130422, 3, ENSP000003485544MINT-7947479 I2D: score=7 STRING: ENSP00000348554
    CDC23Q9UJX22, 3, ENSP000003783504MINT-7947479 I2D: score=7 STRING: ENSP00000378350
    ANAPC1Q9H1A42, 3, ENSP000003391094MINT-7947479 I2D: score=2 STRING: ENSP00000339109
    PLK1P533502, 3, ENSP000003000934MINT-7947479 I2D: score=2 STRING: ENSP00000300093
    ANAPC7Q9UJX32, 3, ENSP000003943944MINT-7947479 I2D: score=1 STRING: ENSP00000394394
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 17):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000079regulation of cyclin-dependent protein serine/threonine kinase activity TAS9469815
    GO:0000278mitotic cell cycle TAS--
    GO:0006511ubiquitin-dependent protein catabolic process TAS9469815
    GO:0007067mitosis IEA--
    GO:0007094mitotic spindle assembly checkpoint TAS--

    ANAPC2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ANAPC2 (ANC2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ANAPC2 gene: 
    NM_013366.3  

    Unigene Cluster for ANAPC2:

    Anaphase promoting complex subunit 2
    Hs.533262  [show with all ESTs]
    Unigene Representative Sequence: NM_013366
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000487917 ENST00000323927(uc004clq.1 uc004clr.1 uc011mer.1)
    ENST00000493730 ENST00000483432 ENST00000485970 ENST00000471131 ENST00000495611

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      QuantiFast Probe-based Assays in human, mouse, rat ANAPC2

    Additional mRNA sequence: 

    AB037827.1 AF191337.1 AK294601.1 AK296204.1 BC001579.1 BC009487.2 BC032503.1 

    13 DOTS entries:

    DT.86854408  DT.92437772  DT.92437773  DT.95303791  DT.99989464  DT.100781573  DT.100781578  DT.95303789 
    DT.100657167  DT.121168196  DT.121168222  DT.95303803  DT.91737935 

    Selected AceView cDNA sequences (see all 212):

    BC001579 AF191337 BM666938 BQ718639 AI925468 BM919786 AA862592 AW732734 
    BC032503 BF002414 BX377538 CA397471 BI772477 BM967262 BM854587 BM549825 
    BQ213026 BQ439985 BM563359 BE894530 AA313959 CN484926 BQ720132 BQ876970 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ANAPC2 (see all 7)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12a · 12b ^ 13a · 13b · 13c ^ 14
    SP1:                    -                                                                             -                                 
    SP2:                                            -                                                     -                                 
    SP3:                                                                                                                                    
    SP4:                                                                                                  -                                 
    SP5:        -           -                                                                                                               


    ECgene alternative splicing isoforms for ANAPC2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ANAPC2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCCACCCCCA
    ANAPC2 Expression
    About this image


    ANAPC2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Brain (Nervous System)
             Cerebellum
     
     Lymph (Hematopoietic System)
    ANAPC2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ANAPC2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.533262
        Pathway & Disease-focused RT2 Profiler PCR Arrays including ANAPC2: 
              Ubiquitination (Ubiquitylation) Pathway in human mouse rat
              Cell Cycle in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANAPC2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ANAPC2 gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Anapc21 , 5 anaphase promoting complex subunit 21, 5 85.95(n)1
    94.52(a)1
      2 (17.12 cM)5
    991521  NM_175300.41  NP_780509.21 
     252724785 
    chicken
    (Gallus gallus)
    Aves ANAPC21 anaphase promoting complex subunit 2 75.93(n)
    72.09(a)
      417258  XM_415533.4  XP_415533.2 
    lizard
    (Anolis carolinensis)
    Reptilia ANAPC26
    anaphase promoting complex subunit 2
    65(a)
    1 ↔ 1
    AAWZ02036331(10564-27314)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.154422 Transcribed sequence with moderate similarity to protein more 77.25(n)    AL973405.2 
    zebrafish
    (Danio rerio)
    Actinopterygii anapc21 anaphase promoting complex subunit 2 61.22(n)
    57.53(a)
      100318335  NM_001256746.1  NP_001243675.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta mr1 morula 50.98(n)
    41.02(a)
      45906  NM_138018.2  NP_611862.1 
    worm
    (Caenorhabditis elegans)
    Secernentea apc-26
    Protein APC-2 (apc-2) mRNA, complete cds
    24(a)
    1 ↔ 1
    III(8080613-8083696) WBGene00000143
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes APC2(YLR127C)4 Subunit of the Anaphase-Promoting Complex/Cyclosome more   --   12(398319-395758) 850818  NP_013228.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons APC21 APC2 48.19(n)
    40.04(a)
      815008  NM_126495.2  NP_178543.2 
    rice
    (Oryza sativa)
    Liliopsida Os04g04848001 Os04g0484800 48.65(n)
    43(a)
      4336204  NM_001059662.1  NP_001053127.2 


    ENSEMBL Gene Tree for ANAPC2 (if available)
    TreeFam Gene Tree for ANAPC2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for ANAPC2 (see all 362)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1914096021,2
    --140070099(+) AACAGC/TCCCTC 1 -- int10--------
    rs413170101,2
    C,F--140070188(+) ATCACC/TGCCTG 2 A syn12Minor allele frequency- T:0.00NA EU 5015
    rs789807971,2
    C--140070206(+) GTGACC/TGCCAC 2 A syn12Minor allele frequency- T:0.01EA EU 925
    rs1510859671,2
    F--140070226(+) GCGGTC/TGGCCA 2 N D mis11Minor allele frequency- T:0.00NA 4438
    rs1175387901,2
    C--140070227(+) CGGTCG/AGCCAG 2 /A syn11Minor allele frequency- A:0.00NA 4432
    rs1839361571,2
    C--140070313(+) AGCACA/GGGCAG 1 -- int10--------
    rs760695681,2
    F--140070358(+) CCACCT/CGGTAC 1 -- int11Minor allele frequency- C:0.03WA 118
    rs726193531,2
    C,F--140070369(+) CAGTGA/GGAAAG 1 -- int12Minor allele frequency- G:0.05WA EA 238
    rs1480374971,2
    C--140070394(+) ACCTGC/TCCCAC 1 -- int10--------
    rs413074381,2
    C,F--140070397(+) TGCCCC/TACCCC 1 -- int11Minor allele frequency- T:0.14NA 120

    HapMap Linkage Disequilibrium report for ANAPC2 (140069236 - 140083057 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for ANAPC2 (see all 25):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2422220CNV Deletion17116639
    dgv8416n71CNV Loss21882294
    dgv8439n71CNV Loss21882294
    dgv8445n71CNV Loss21882294
    dgv8441n71CNV Loss21882294
    dgv8428n71CNV Loss21882294
    nsv894521CNV Loss21882294
    dgv8450n71CNV Loss21882294
    dgv8423n71CNV Loss21882294
    dgv8451n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ANAPC2
    DNA2.0 Custom Variant and Variant Library Synthesis for ANAPC2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606946    OMIM disorders: --

    7 diseases for ANAPC2:    
    About MalaCards
    brain cancer    retinoblastoma    tonsillitis    malaria
    thyroiditis    neuronitis    prostatitis


    ANAPC2 for disorders           About GeneDecksing


    Export disorders for ANAPC2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ANAPC2 gene, integrated from 10 sources (see all 78):
    (articles sorted by number of sources associating them with ANAPC2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. APC2 cullin protein and APC11 RING protein comprise the minimal ubiquitin ligase module of the anaphase-promoting complex. (PubMed id 11739784)1, 2, 3 Tang Z.... Yu H. (Mol. Biol. Cell 2001)
    2. Identification of a cullin homology region in a subunit of the anaphase-promoting complex. (PubMed id 9469815)1, 2, 9 Yu H.... Kirschner M.W. (Science 1998)
    3. Mechanism of ubiquitin-chain formation by the human anaphase- promoting complex. (PubMed id 18485873)1, 2 Jin L.... Rape M. (Cell 2008)
    4. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (Nat. Biotechnol. 2006)
    5. Localization of the coactivator Cdh1 and the cullin subunit Apc2 in a cryo-electron microscopy model of vertebrate APC/C. (PubMed id 16364912)1, 2 Dube P.... Stark H. (Mol. Cell 2005)
    6. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (Nature 2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Mitotic regulation of the human anaphase-promoting complex by phosphorylation. (PubMed id 14657031)1, 2 Kraft C....Peters J.-M. (EMBO J. 2003)
    9. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)1, 2 Nagase T.... Ohara O. (DNA Res. 2000)
    10. The G2/M regulator histone demethylase PHF8 is targeted for degradation by the anaphase-promoting complex containing CDC20. (PubMed id 23979597)1 Lim H.J....Shi Y. (Mol. Cell. Biol. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 29882 HGNC: 19989 AceView: ANAPC2 Ensembl:ENSG00000176248 euGenes: HUgn29882
    ECgene: ANAPC2 Kegg: 29882 H-InvDB: ANAPC2

    (According to HUGE)
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    HUGE: KIAA1406

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ANAPC2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ANAPC2 gene:
    Search GeneIP for patents involving ANAPC2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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