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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ANAPC2 Gene

protein-coding GIFtS: 57
GCID: GC09M140069

anaphase promoting complex subunit 2

Explore 2 diseases affiliated with
ANAPC2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Anaphase Promoting Complex Subunit 2¹ ²
APC2¹ ² ³ ⁵
KIAA1406¹ ³ ⁵
Cyclosome Subunit 2² ³
RP11-350O14.5²
Anaphase-Promoting Complex Subunit 2²

External Ids:	HGNC: 19989¹	Entrez Gene: 29882²	Ensembl: ENSG00000176248⁷	OMIM: 606946⁵	UniProtKB: Q9UJX6³

Export aliases for ANAPC2 gene to outside databases

Previous GC identifers: GC09M131759 GC09M133510 GC09M135426 GC09M137345 GC09M139189 GC09M109530

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ANAPC2:

A large protein complex, termed the anaphase-promoting complex (APC), or the cyclosome, promotes metaphase-anaphase

transition by ubiquitinating its specific substrates such as mitotic cyclins and anaphase inhibitor, which are

subsequently degraded by the 26S proteasome. Biochemical studies have shown that the vertebrate APC contains eight

subunits. The composition of the APC is highly conserved in organisms from yeast to humans. The product of this gene

is a component of the complex and shares sequence similarity with a recently identified family of proteins called

cullins, which may also be involved in ubiquitin-mediated degradation. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: ANC2_HUMAN, Q9UJX6

Function: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase

that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating

ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked

polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. The

CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the

presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 drives presynaptic

differentiation

Gene Wiki entry for ANAPC2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000009.11 NC_018920.1 NT_024000.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ANAPC2 gene promoter:
CREB deltaCREB MyoD Nkx2-5 Pax-4a
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ANAPC2 promoter sequence

Search SABiosciences Chromatin IP Primers for ANAPC2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ANAPC2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q34.3 Ensembl cytogenetic band: 9q34.3 HGNC cytogenetic band: 9q34.3

ANAPC2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ANAPC2 gene location

GeneLoc information about chromosome 9 GeneLoc Exon Structure

GeneLoc location for GC09M140069: view genomic region (about GC identifiers)

Start:	140,069,236 bp from pter	End:	140,083,057 bp from pter
Size:	13,822 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ANC2_HUMAN, Q9UJX6 (See protein sequence)

Recommended Name: Anaphase-promoting complex subunit 2

Size: 822 amino acids; 93828 Da

Subunit: Interacts with NEUROD2 (By similarity). The APC/C is composed of at least 12 subunits. Interacts through the

cullin domain with ANAPC11 and with UBCH10

Sequence caution: Sequence=AAH09487.2; Type=Erroneous translation; Note=Wrong choice of frame;

Secondary accessions: Q5VSG1 Q96DG5 Q96GG4 Q9P2E1

Alternative splicing: 2 isoforms: Q9UJX6-1 Q9UJX6-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ANAPC2: NX_Q9UJX6

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9UJX6

ANAPC2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_037498.1

ENSEMBL proteins:

ENSP00000314004

Reactome Protein details: Q9UJX6
Human Recombinant Protein Products:

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	Uscn Proteins for ANAPC2

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	--	--
GO:0005654	nucleoplasm	TAS	--
GO:0005680	anaphase-promoting complex	IDA	16364912
GO:0005829	cytosol	TAS	--

ANAPC2 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for ANAPC2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ANAPC2 for domains About GeneDecksing

4 InterPro domains/families:

IPR011991 WHTH_trsnscrt_rep_DNA-bd_dom

IPR016158 Cullin_homology

IPR014786 APC_su2_C

IPR001373 Cullin_N

Graphical View of Domain Structure for InterPro Entry Q9UJX6

ProtoNet protein and cluster: Q9UJX6

UniProtKB/Swiss-Prot: ANC2_HUMAN, Q9UJX6

Similarity: Belongs to the cullin family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: ANC2_HUMAN, Q9UJX6

Function: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase

that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating

ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked

polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. The

CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the

presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 drives presynaptic

differentiation

miRNA Products:		OriGene 3'-UTR Clone: ANAPC2 Browse MicroRNA Expression Plasmids
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANAPC2

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004842	ubiquitin-protein ligase activity	TAS	9469815
GO:0031625	ubiquitin protein ligase binding	IEA	--

ANAPC2 for ontologies About GeneDecksing

6 GenomeRNAi human phenotypes for ANAPC2:

Decreased viability of wild-ty	Increased cell death in DLD-1	Increased cell death in breast	Increased cell number in S
Synthetic lethal with Ras	Upregulation of Wnt/beta-caten

Animal Models:
Mouse knock-out Anapc2^tm2Kna for ANAPC2
7 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Anapc2):

cellular	hematopoietic system	homeostasis/metabolism	liver/biliary system	mortality/aging
normal	skeleton

ANAPC2 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/24 super-pathways (see all 24) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Ubiquitinated Orc1 is degraded by the proteasome

8/15 pathways (see all 15)
APC/C:Cdh1-mediated degradation of Skp2	0.74	APC/C:Cdc20 mediated degradation of mitotic proteins	0.69
APC/C:Cdc20 mediated degradation of Securin	0.74	APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	0.69
Degradation of multiubiquitinated Securin	0.74	Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	0.68
Autodegradation of Cdh1 by Cdh1:APC/C	0.70	Regulation of APC/C activators between G1/S and early anaphase	0.62

APC-Cdc20 mediated degradation of Nek2A

8/10 pathways (see all 10)
Degradation of multiubiquitinated Nek2A	1.00	Degradation of multiubiquitinated Cyclin B	0.76
APC-Cdc20 mediated degradation of Nek2A	1.00	Mitotic Spindle Checkpoint	0.75
Inactivation of APC/C via direct inhibition of the APC/C complex	0.78	Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	0.60
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	0.78	Phosphorylation of the APC/C	0.54

M Phase

M Phase	1.00	Mitotic Anaphase	0.85
Mitotic M-M/G1 phases	0.88	Separation of Sister Chromatids	0.80
Mitotic Metaphase and Anaphase	0.85

Antigen processing: Ubiquitination & Proteasome degradation

	Antigen processing: Ubiquitination & Proteasome degradation	1.00			Polyubiquitination of substrate	0.75
	Class I MHC mediated antigen processing & presentation	0.83			Ubiquitin mediated proteolysis	0.36

Cell cycle_Spindle assembly and chromosome separation

Cell cycle_Spindle assembly and chromosome separation

1.00

Cell cycle Spindle assembly and chromosome separation

0.94

Pathway sources
See GeneCards unified pathways
Show all pathways

5/9 EMD Millipore Pathways for ANAPC2 (see all 9)

	Cell cycle Role of APC in cell cycle regulation
	Meiosis
	Cell cycle Regulation of G1/S transition (part 1)
	Development TGF-beta receptor signaling
	Signal transduction PKA signaling

5/6 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for ANAPC2 (see all 6)

	Activation of PKA through GPCR
	Remodeling of Adherens Junctions
	cAMP Pathway
	CDC42 Pathway
	Mitotic Roles of Polo Like Kinases

2 Cell Signaling Technology (CST) Pathways for ANAPC2

	Cell Cycle / Checkpoint Control
	Protein Stability

5/7 GeneGo (Thomson Reuters) Pathways for ANAPC2 (see all 7)

	Cell cycle Role of APC in cell cycle regulation
	G-protein signaling G-Protein alpha-s signaling cascades
	Signal transduction PKA signaling
	Cell cycle Regulation of G1/S transition (part 1)
	Cell cycle Spindle assembly and chromosome separation

1 BioSystems Pathway for ANAPC2

TGF-beta Receptor Signaling Pathway

5/36 Reactome Pathways for ANAPC2 (see all 36)

	APC/C:Cdc20 mediated degradation of mitotic proteins
	Phosphorylation of the APC/C
	APC/C:Cdc20 mediated degradation of Securin
	Cdc20:Phospho-APC/C mediated degradation of Cyclin A
	Antigen processing: Ubiquitination & Proteasome degradation

4 Kegg Pathways (Kegg details for ANAPC2):

	Cell cycle
	Oocyte meiosis
	Ubiquitin mediated proteolysis
	Progesterone-mediated oocyte maturation

UniProtKB/Swiss-Prot: ANC2_HUMAN, Q9UJX6

Pathway: Protein modification; protein ubiquitination

ANAPC2 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for ANAPC2

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/636 Interacting proteins for ANAPC2 (Q9UJX6^{2, 3} ENSP00000314004⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 636)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CDC16	Q13042²^,³, ENSP00000348554⁴	MINT-7947479 I2D: score=7 STRING: ENSP00000348554
CDC23	Q9UJX2²^,³, ENSP00000378350⁴	MINT-7947479 I2D: score=7 STRING: ENSP00000378350
ANAPC1	Q9H1A4²^,³, ENSP00000339109⁴	MINT-7947479 I2D: score=2 STRING: ENSP00000339109
PLK1	P53350²^,³, ENSP00000300093⁴	MINT-7947479 I2D: score=2 STRING: ENSP00000300093
ANAPC7	Q9UJX3²^,³, ENSP00000394394⁴	MINT-7947479 I2D: score=1 STRING: ENSP00000394394

About this table

Gene Ontology (GO): 5/20 biological process terms (GO ID links to tree view) (see all 20): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000075	cell cycle checkpoint	TAS	--
GO:0000079	regulation of cyclin-dependent protein kinase activity	TAS	9469815
GO:0000278	mitotic cell cycle	TAS	--
GO:0006511	ubiquitin-dependent protein catabolic process	TAS	9469815
GO:0007067	mitosis	IEA	--

ANAPC2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ANAPC2
Search CenterWatch for drugs/clinical trials and news about ANAPC2 / ANC2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ANAPC2 gene:

NM_013366.3

Unigene Cluster for ANAPC2:

Anaphase promoting complex subunit 2

Hs.533262 [show with all ESTs]

Unigene Representative Sequence: NM_013366

8 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000487917 ENST00000459740 ENST00000323927(uc004clq.1 uc004clr.1 uc011mer.1)

ENST00000493730 ENST00000483432 ENST00000485970 ENST00000471131 ENST00000495611

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Additional cDNA sequence:

AB037827.1 AF191337.1 AK294601.1 AK296204.1 BC001579.1 BC009487.2 BC032503.1

13 DOTS entries:

DT.86854408 DT.92437772 DT.92437773 DT.95303791 DT.99989464 DT.100781573 DT.100781578 DT.95303789

DT.100657167 DT.121168196 DT.121168222 DT.95303803 DT.91737935

24/212 AceView cDNA sequences (see all 212):

AA313959 BQ213026 AI928361 BE894530 AW087285 BC009487 BX377538 BM695853

BQ718639 BF002414 BQ673039 AF191337 CA309267 BM919786 BM549825 BI772477

BC032503 BM563359 CN484926 BM051985 CA397471 BM967262 NM_013366 BQ439985

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for ANAPC2 (see all 7) About this scheme

ExUns:	1	^	2	^	3	^	4a	·	4b	·	4c	^	5	^	6a	·	6b	^	7	^	8	^	9	^	10a	·	10b	·	10c	^	11	^	12a	·	12b	^	13a	·	13b	·	13c	^	14
SP1:							-																										-
SP2:															-																		-
SP3:
SP4:																																	-
SP5:			-				-

ECgene alternative splicing isoforms for ANAPC2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ANAPC2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCCACCCCCA

About this image
See ANAPC2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ANAPC2

SOURCE GeneReport for Unigene cluster: Hs.533262

SABiosciences Expression via Pathway-Focused PCR Arrays including ANAPC2:

Ubiquitination (Ubiquitylation) Pathway in human mouse rat

Cell Cycle in human mouse rat

Ubiquitin Ligases in human mouse rat

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for ANAPC2 gene from 9/28 species (see all 28) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Anapc2^{1 , 5}	anaphase promoting complex subunit 2^{1, 5}	86(n)¹ 94.75(a)¹		2 (17.12 cM)⁵ 99152¹ NM_175300.4¹ NP_780509.2¹ 25272478⁵
chicken (Gallus gallus)	Aves	ANAPC2¹	anaphase promoting complex subunit 2	75.71(n) 71.62(a)		417258 XM_415533.3 XP_415533.2
lizard (Anolis carolinensis)	Reptilia	ANAPC2⁶	--	69(a)	1 ↔ 1	AAWZ02036331(11650-27062)
tropical clawed frog (Xenopus tropicalis)	Amphibia	Str.15442²	Transcribed sequence with moderate similarity to protein more	77.25(n)		AL973405.2
zebrafish (Danio rerio)	Actinopterygii	anapc2¹	anaphase promoting complex subunit 2	61(n) 57.27(a)		100318335 XM_002662119.1 XP_002662165.1
fruit fly (Drosophila melanogaster)	Insecta	mr¹	morula	50.14(n) 39.97(a)		45906 NM_138018.2 NP_611862.1
worm (Caenorhabditis elegans)	Secernentea	apc-2⁶	Anaphase-promoting complex subunit 2	22(a)	1 ↔ 1	III(8080547-8083630)
thale cress (Arabidopsis thaliana)	eudicotyledons	APC2¹	anaphase-promoting complex subunit 2	44.02(n) 32.98(a)		815008 NM_126495.2 NP_178543.2
rice (Oryza sativa)	Liliopsida	Os04g0484800¹	hypothetical protein	44.94(n) 36.6(a)		4336204 NM_001059662.1 NP_001053127.2

ENSEMBL Gene Tree for ANAPC2 (if available)
TreeFam Gene Tree for ANAPC2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 9 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs77173745^1,2	C,F,	--	109528939(+)	`GGTGAC/TCCCAG`	1	--	us2k¹		1		WA	118
rs117907571^1,2	C,F,	--	109529040(+)	`TGGCCC/TGGGCG`	1	--	us2k¹		1		NA	120
rs28617401^1,2	C	--	109529708(+)	`CACCAG/TCAGCT`	1	--	us2k¹ ese³		0	--	--	--	--
rs115836794^1,2		--	140068911(+)	`GCTGAG/ACAGAG`	2	--	ds500¹ us2k¹		1		WA	118
rs144743795^1,2		--	140069016(+)	`TGAGCC/TGTGGC`	2	--	us2k¹ ds500¹		0	--	--	--	--
rs79955544^1,2	C,F,	--	140069024(+)	`GGCCCG/AGGCGT`	2	--	us2k¹ ds500¹		1		WA	118
rs188375676^1,2		--	140069025(+)	`GCCCGA/GGCGTG`	2	--	ds500¹ us2k¹		0	--	--	--	--
rs117489231^1,2	F,	--	140069082(+)	`GGCCCG/AGGATT`	2	--	ds500¹ us2k¹		1		NA	120
rs78332229^1,2	C,	--	140069093(+)	`CTCTC-/AGGAGGCT`	2	--	us2k¹ ds500¹		0	--	--	--	--
rs140485004^1,2		--	140069172(+)	`AGGCT-/GAGA GAGAG`	2	--	ds500¹ us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for ANAPC2 (140069236 - 140083057 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for ANAPC2
1 CNV: 5415

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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ANAPC2 for disorders           About GeneDecksing

OMIM gene information: 606946    OMIM disorders: --

2 diseases for ANAPC2:    About MalaCards

neuronitis retinoblastoma

Export disorders for ANAPC2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for ANAPC2 gene, integrated from 9 sources (see all 66):
(articles sorted by number of sources associating them with ANAPC2)

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APC2 cullin protein and APC11 RING protein comprise the minimal ubiquitin ligase module of the anaphase-promoting complex. (PubMed id 11739784)^{1, 2, 3} Tang Z.... Yu H. (2001)
Identification of a cullin homology region in a subunit of the anaphase-promoting complex. (PubMed id 9469815)^{1, 2, 9} Yu H.... Kirschner M.W. (1998)
Mechanism of ubiquitin-chain formation by the human anaphase-promoting complex. (PubMed id 18485873)^{1, 2} Jin L....Rape M. (2008)
A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)^{1, 2} Beausoleil S.A.... Gygi S.P. (2006)
Localization of the coactivator Cdh1 and the cullin subunit Apc2 in a cryo-electron microscopy model of vertebrate APC/C. (PubMed id 16364912)^{1, 2} Dube P.... Stark H. (2005)
DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)^{1, 2} Humphray S.J.... Dunham I. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Mitotic regulation of the human anaphase-promoting complex by phosphorylation. (PubMed id 14657031)^{1, 2} Kraft C....Peters J.-M. (2003)
Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)^{1, 2} Nagase T.... Ohara O. (2000)
A census of human soluble protein complexes. (PubMed id 22939629)¹ Havugimana P.C....Emili A. (2012)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 29882	HGNC: 19989	AceView: ANAPC2	Ensembl:ENSG00000176248	euGenes: HUgn29882
ECgene: ANAPC2	Kegg: 29882	H-InvDB: ANAPC2

(According to HUGE)
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HUGE: KIAA1406

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for ANAPC2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ANAPC2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for ANAPC2 gene:
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ANAPC2 Gene

anaphase promoting complex subunit 2

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ANAPC2 Gene

anaphase promoting complex subunit 2

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