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Aliases for ANAPC2 Gene

Aliases for ANAPC2 Gene

  • Anaphase Promoting Complex Subunit 2 2 3
  • APC2 3 4 6
  • Cyclosome Subunit 2 3 4
  • KIAA1406 4 6
  • Anaphase-Promoting Complex Subunit 2 3

External Ids for ANAPC2 Gene

Summaries for ANAPC2 Gene

Entrez Gene Summary for ANAPC2 Gene

  • A large protein complex, termed the anaphase-promoting complex (APC), or the cyclosome, promotes metaphase-anaphase transition by ubiquitinating its specific substrates such as mitotic cyclins and anaphase inhibitor, which are subsequently degraded by the 26S proteasome. Biochemical studies have shown that the vertebrate APC contains eight subunits. The composition of the APC is highly conserved in organisms from yeast to humans. The product of this gene is a component of the complex and shares sequence similarity with a recently identified family of proteins called cullins, which may also be involved in ubiquitin-mediated degradation. [provided by RefSeq, Jul 2008]

GeneCards Summary for ANAPC2 Gene

ANAPC2 (Anaphase Promoting Complex Subunit 2) is a Protein Coding gene. Among its related pathways are Regulation of actin cytoskeleton and Class I MHC mediated antigen processing and presentation. GO annotations related to this gene include ubiquitin-protein transferase activity and ubiquitin protein ligase binding.

UniProtKB/Swiss-Prot for ANAPC2 Gene

  • Together with the RING-H2 protein ANAPC11, constitutes the catalytic component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of Lys-11-linked polyubiquitin chains and, to a lower extent, the formation of Lys-48- and Lys-63-linked polyubiquitin chains. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 drives presynaptic differentiation.

Gene Wiki entry for ANAPC2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANAPC2 Gene

Genomics for ANAPC2 Gene

Genomic Location for ANAPC2 Gene

Start:
137,174,784 bp from pter
End:
137,188,605 bp from pter
Size:
13,822 bases
Orientation:
Minus strand

Genomic View for ANAPC2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ANAPC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANAPC2 Gene

Regulatory Elements for ANAPC2 Gene

Proteins for ANAPC2 Gene

  • Protein details for ANAPC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UJX6-ANC2_HUMAN
    Recommended name:
    Anaphase-promoting complex subunit 2
    Protein Accession:
    Q9UJX6
    Secondary Accessions:
    • Q5VSG1
    • Q96DG5
    • Q96GG4
    • Q9P2E1

    Protein attributes for ANAPC2 Gene

    Size:
    822 amino acids
    Molecular mass:
    93828 Da
    Quaternary structure:
    • Interacts with NEUROD2 (By similarity). The mammalian APC/C is composed of 14 distinct subunits that assemble into a complex of at least 19 chains with a combined molecular mass of around 1.2 MDa. Interacts through the cullin domain with ANAPC11 and with UBCH10.
    SequenceCaution:
    • Sequence=AAH09487.2; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305};

    Alternative splice isoforms for ANAPC2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ANAPC2 Gene

Proteomics data for ANAPC2 Gene at MOPED

Post-translational modifications for ANAPC2 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys134, Lys190, and Lys228

Other Protein References for ANAPC2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for ANAPC2 Gene

Domains for ANAPC2 Gene

Gene Families for ANAPC2 Gene

HGNC:
  • ANAPC :Anaphase promoting complex subunits

Protein Domains for ANAPC2 Gene

Suggested Antigen Peptide Sequences for ANAPC2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UJX6

UniProtKB/Swiss-Prot:

ANC2_HUMAN
Family:
  • Belongs to the cullin family.:
    • Q9UJX6
genes like me logo Genes that share domains with ANAPC2: view

Function for ANAPC2 Gene

Molecular function for ANAPC2 Gene

UniProtKB/Swiss-Prot Function: Together with the RING-H2 protein ANAPC11, constitutes the catalytic component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of Lys-11-linked polyubiquitin chains and, to a lower extent, the formation of Lys-48- and Lys-63-linked polyubiquitin chains. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 drives presynaptic differentiation.

Gene Ontology (GO) - Molecular Function for ANAPC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031625 ubiquitin protein ligase binding IEA --
genes like me logo Genes that share ontologies with ANAPC2: view
genes like me logo Genes that share phenotypes with ANAPC2: view

Animal Models for ANAPC2 Gene

MGI Knock Outs for ANAPC2:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for ANAPC2 Gene

Localization for ANAPC2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ANAPC2 Gene COMPARTMENTS Subcellular localization image for ANAPC2 gene
Compartment Confidence
nucleus 5
cytosol 4
mitochondrion 1

Gene Ontology (GO) - Cellular Components for ANAPC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm TAS --
GO:0005680 anaphase-promoting complex IDA 16364912
GO:0005829 cytosol TAS --
GO:0031461 cullin-RING ubiquitin ligase complex --
genes like me logo Genes that share ontologies with ANAPC2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ANAPC2 Gene

Pathways for ANAPC2 Gene

SuperPathways for ANAPC2 Gene

genes like me logo Genes that share pathways with ANAPC2: view

UniProtKB/Swiss-Prot Q9UJX6-ANC2_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for ANAPC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle TAS --
GO:0006511 ubiquitin-dependent protein catabolic process --
GO:0007067 mitotic nuclear division IEA --
GO:0007094 mitotic spindle assembly checkpoint TAS --
GO:0031145 anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process TAS --
genes like me logo Genes that share ontologies with ANAPC2: view

Transcripts for ANAPC2 Gene

Unigene Clusters for ANAPC2 Gene

Anaphase promoting complex subunit 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ANAPC2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12a · 12b ^ 13a · 13b · 13c ^ 14
SP1: - -
SP2: - -
SP3:
SP4: -
SP5: - -
SP6:
SP7:

Relevant External Links for ANAPC2 Gene

GeneLoc Exon Structure for
ANAPC2
ECgene alternative splicing isoforms for
ANAPC2

Expression for ANAPC2 Gene

mRNA expression in normal human tissues for ANAPC2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ANAPC2 Gene

SOURCE GeneReport for Unigene cluster for ANAPC2 Gene Hs.533262

genes like me logo Genes that share expressions with ANAPC2: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ANAPC2 Gene

Orthologs for ANAPC2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ANAPC2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ANAPC2 35
  • 96.3 (n)
  • 95.52 (a)
ANAPC2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 94 (a)
OneToMany
-- 36
  • 86 (a)
OneToMany
dog
(Canis familiaris)
Mammalia ANAPC2 35
  • 89.45 (n)
  • 95.35 (a)
mouse
(Mus musculus)
Mammalia Anapc2 35
  • 85.95 (n)
  • 94.52 (a)
Anapc2 16
Anapc2 36
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ANAPC2 36
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ANAPC2 36
  • 52 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Anapc2 35
  • 86.48 (n)
  • 94.88 (a)
chicken
(Gallus gallus)
Aves ANAPC2 35
  • 75.93 (n)
  • 72.09 (a)
ANAPC2 36
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ANAPC2 36
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia anapc2 35
  • 69.08 (n)
  • 68.03 (a)
Str.15442 35
zebrafish
(Danio rerio)
Actinopterygii anapc2 35
  • 61.22 (n)
  • 57.53 (a)
anapc2 36
  • 55 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005048 35
  • 50.69 (n)
  • 39.42 (a)
fruit fly
(Drosophila melanogaster)
Insecta mr 35
  • 50.98 (n)
  • 41.02 (a)
mr 36
  • 36 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea apc-2 36
  • 24 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes APC2 36
  • 18 (a)
OneToOne
APC2 38
thale cress
(Arabidopsis thaliana)
eudicotyledons APC2 35
  • 48.19 (n)
  • 40.04 (a)
rice
(Oryza sativa)
Liliopsida Os04g0484800 35
  • 48.65 (n)
  • 43 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 29 (a)
OneToOne
Species with no ortholog for ANAPC2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ANAPC2 Gene

ENSEMBL:
Gene Tree for ANAPC2 (if available)
TreeFam:
Gene Tree for ANAPC2 (if available)

Paralogs for ANAPC2 Gene

No data available for Paralogs for ANAPC2 Gene

Variants for ANAPC2 Gene

Sequence variations from dbSNP and Humsavar for ANAPC2 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs3922734 -- 137,186,047(+) TCGCT(A/G)TCACC intron-variant
rs3922735 -- 137,186,131(+) CCTCC(A/G)TGCTC intron-variant
rs4880219 -- 137,176,186(+) AAAGA(C/T)AGGAA intron-variant
rs9775861 -- 137,182,575(+) CCAAA(C/G)GAGTC intron-variant
rs9775873 -- 137,182,861(+) CTGGA(A/G)ATGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ANAPC2 Gene

Variant ID Type Subtype PubMed ID
nsv894387 CNV Gain 21882294
esv2422220 CNV Deletion 17116639
dgv8412n71 CNV Loss 21882294
dgv8416n71 CNV Loss 21882294
nsv524322 CNV Loss 19592680
nsv894469 CNV Loss 21882294
dgv8423n71 CNV Loss 21882294
nsv894502 CNV Loss 21882294
nsv894506 CNV Gain 21882294
dgv8428n71 CNV Loss 21882294
nsv894521 CNV Loss 21882294
dgv8437n71 CNV Gain 21882294
dgv8439n71 CNV Loss 21882294
dgv8441n71 CNV Loss 21882294
dgv8442n71 CNV Loss 21882294
dgv8445n71 CNV Loss 21882294
dgv8446n71 CNV Loss 21882294
dgv8447n71 CNV Loss 21882294
dgv8450n71 CNV Loss 21882294
nsv894603 CNV Gain+Loss 21882294
dgv8451n71 CNV Loss 21882294
dgv8452n71 CNV Gain+Loss 21882294
dgv8453n71 CNV Gain 21882294
dgv8454n71 CNV Gain 21882294
dgv8455n71 CNV Gain+Loss 21882294

Relevant External Links for ANAPC2 Gene

HapMap Linkage Disequilibrium report
ANAPC2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANAPC2 Gene

Disorders for ANAPC2 Gene

No disorders were found for ANAPC2 Gene.

No data available for UniProtKB/Swiss-Prot for ANAPC2 Gene

Publications for ANAPC2 Gene

  1. Identification of a cullin homology region in a subunit of the anaphase-promoting complex. (PMID: 9469815) Yu H. … Kirschner M.W. (Science 1998) 3 4 23
  2. APC2 cullin protein and APC11 RING protein comprise the minimal ubiquitin ligase module of the anaphase-promoting complex. (PMID: 11739784) Tang Z. … Yu H. (Mol. Biol. Cell 2001) 2 3 4
  3. Mitotic regulation of the human anaphase-promoting complex by phosphorylation. (PMID: 14657031) Kraft C. … Peters J.-M. (EMBO J. 2003) 3 4
  4. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for ANAPC2 Gene

  • antibodies-online proteins for ANAPC2
  • antibodies-online antibodies for ANAPC2
  • antibodies-online kits for ANAPC2

Sources for ANAPC2 Gene

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