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ANAPC16 Gene

protein-coding   GIFtS: 44
GCID: GC10P073975

Anaphase Promoting Complex Subunit 16

(Previous name: chromosome 10 open reading frame 104)
(Previous symbol: C10orf104)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Anaphase Promoting Complex Subunit 161 2     Chromosome 10 Open Reading Frame 1041
C10orf1041 2 3 5     CENP-272
Centromere Protein 271 2     Anaphase-Promoting Complex Subunit 162
Cyclosome Subunit 162 3     bA570G20.32
APC162 3     Metabolic Syndrome-Associated Protein2
MSAG2 5     

External Ids:    HGNC: 269761   Entrez Gene: 1195042   Ensembl: ENSG000001662957   OMIM: 6134275   UniProtKB: Q96DE53   

Export aliases for ANAPC16 gene to outside databases

Previous GC identifer: GC10P067970


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ANAPC16 Gene:
ANAPC16 (anaphase promoting complex subunit 16) is a protein-coding gene.

UniProtKB/Swiss-Prot: APC16_HUMAN, Q96DE5
Function: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin
ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by
mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of
'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked
polyubiquitin chains




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000010.10  NC_018921.2  NT_030059.14  
Regulatory elements:
   Search for regulatory transcription factor binding sites for ANAPC16
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidANAPC16 promoter sequence
   Search Chromatin IP Primers for ANAPC16

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ANAPC16


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q22.1   Ensembl cytogenetic band:  10q22.1   HGNC cytogenetic band: 10q22.2

ANAPC16 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ANAPC16 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P073975:  view genomic region     (about GC identifiers)

Start:
73,975,758 bp from pter      End:
73,995,618 bp from pter
Size:
19,861 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: APC16_HUMAN, Q96DE5 (See protein sequence)
Recommended Name: Anaphase-promoting complex subunit 16  
Size: 110 amino acids; 11667 Da
Subunit: The APC/C is composed of at least 12 subunits. ANAPC16 associates with the rest of the complex
independently of ANAPC2 and ANAPC11

Explore the universe of human proteins at neXtProt for ANAPC16: NX_Q96DE5

Explore proteomics data for ANAPC16 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys68
  • Modification sites at PhosphoSitePlus

  • See ANAPC16 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001229475.1  NP_001229476.1  NP_001229477.1  NP_775744.1  

    ENSEMBL proteins: 
     ENSP00000299381  

    ANAPC16 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for ANAPC16

     
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    antibodies-online proteins for ANAPC16 (4 products) 

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ANAPC: Anaphase promoting complex subunits

    ProtoNet protein and cluster: Q96DE5

    UniProtKB/Swiss-Prot: APC16_HUMAN, Q96DE5
    Similarity: Belongs to the APC16 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: APC16_HUMAN, Q96DE5
    Function: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin
    ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by
    mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of
    'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked
    polyubiquitin chains

    Animal Models:

       genOway: Develop your customized and physiologically relevant rodent model for ANAPC16

    miRNA
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    miRTarBase miRNAs that target ANAPC16:
    hsa-mir-16-5p (MIRT004381), hsa-mir-155-5p (MIRT020492), hsa-mir-15a-5p (MIRT003887)

    Block miRNA regulation of human, mouse, rat ANAPC16 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ANAPC16 (see all 71):
    hsa-miR-548j hsa-miR-579 hsa-miR-607 hsa-miR-520e hsa-miR-605 hsa-miR-374a hsa-miR-219-5p hsa-miR-3921
    SwitchGear 3'UTR luciferase reporter plasmidANAPC16 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    APC16_HUMAN, Q96DE5: Cytoplasm. Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3
    mitochondrion1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005680anaphase-promoting complex IDA--
    GO:0005737cytoplasm IDA--

    Find genes that share ontologies with ANAPC16           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    UniProtKB/Swiss-Prot: APC16_HUMAN, Q96DE5
    Pathway: Protein modification; protein ubiquitination

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ANAPC16
    Interactions:

        Search GeneGlobe Interaction Network for ANAPC16

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ANAPC16 (Q96DE53 ENSP000002993814) via UniProtKB, MINT, STRING, and/or I2D (see all 29)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    RBBP6Q7Z6E93, ENSP000003178724I2D: score=2 STRING: ENSP00000317872
    ANAPC1Q9H1A43, ENSP000003391094I2D: score=1 STRING: ENSP00000339109
    ANAPC13Q9BS183, ENSP000003469874I2D: score=1 STRING: ENSP00000346987
    ANAPC5Q9UJX43, ENSP000002618194I2D: score=1 STRING: ENSP00000261819
    CDC26Q8NHZ83, ENSP000003633224I2D: score=1 STRING: ENSP00000363322
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007067mitosis IEA--
    GO:0016567protein ubiquitination IEA--

    Find genes that share ontologies with ANAPC16           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ANAPC16 (APC16)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ANAPC16 gene (4 alternative transcripts): 
    NM_001242546.1  NM_001242547.1  NM_001242548.1  NM_173473.3  

    Unigene Cluster for ANAPC16:

    Anaphase promoting complex subunit 16
    Hs.426296  [show with all ESTs]
    Unigene Representative Sequence: NM_001242546
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000478193 ENST00000299381(uc001jsw.3 uc001jsv.3 uc021psp.1 uc021psq.1 uc021psr.1 uc021pss.1)
    ENST00000470481(uc021psn.1)
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate ANAPC16 (see all 71):
    hsa-miR-548j hsa-miR-579 hsa-miR-607 hsa-miR-520e hsa-miR-605 hsa-miR-374a hsa-miR-219-5p hsa-miR-3921
    SwitchGear 3'UTR luciferase reporter plasmidANAPC16 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ANAPC16
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      QuantiTect SYBR Green Assays in human, mouse, rat ANAPC16
      QuantiFast Probe-based Assays in human, mouse, rat ANAPC16

    Additional mRNA sequence: 

    AF085974.1 AK023981.1 BC009530.1 EU552924.1 NR_038391.1 NR_038392.1 

    Selected DOTS entries (see all 26):

    DT.100038624  DT.456242  DT.86838897  DT.100038625  DT.121298978  DT.100773647  DT.100822176  DT.92327556 
    DT.100822163  DT.121299050  DT.91642226  DT.95156635  DT.100822175  DT.100822181  DT.429295  DT.121298975 
    DT.100822174  DT.121298980  DT.208458  DT.92449643  DT.92449645  DT.92416030  DT.121298981  DT.92449652 

    Selected AceView cDNA sequences (see all 510):

    BU902150 AW514222 BM669482 F19260 BU617881 CD671407 CB135073 N50370 
    AA232284 AA704175 BM689924 R99621 BI004037 AA814454 AW070969 AA937208 
    CA867235 BU184402 AA769877 CA943019 BQ879593 N54721 CR598398 AI826578 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ANAPC16 (see all 11)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5a · 5b · 5c · 5d · 5e · 5f · 5g · 5h
    SP1:                                      -     -     -     -           -     -                                                               
    SP2:                                -     -     -     -     -           -     -                                                               
    SP3:                                            -     -     -           -     -                                                               
    SP4:                                                        -           -     -                                                               
    SP5:                                -     -     -     -     -     -     -     -                                                               


    ECgene alternative splicing isoforms for ANAPC16

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ANAPC16 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCAAATGCTG
    ANAPC16 Expression
    About this image

    ANAPC16 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ANAPC16 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.426296
        Custom PCR Arrays for ANAPC16
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ANAPC16 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Anapc161 , 5 anaphase promoting complex subunit 161, 5 90(n)1
    100(a)1
      10 (29.66 cM)5
    527171  NM_025514.21  NP_079790.11 
     599874095 
    chicken
    (Gallus gallus)
    Aves ANAPC161 anaphase promoting complex subunit 16 82.12(n)
    99.09(a)
      423708  XM_421587.4  XP_421587.3 
    lizard
    (Anolis carolinensis)
    Reptilia ANAPC166
    anaphase promoting complex subunit 16
    96(a)
    1 ↔ 1
    3(51634396-51643382)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.75412 Xenopus laevis transcribed sequence with strong similarity more 81.84(n)    CF547953.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.139492 Transcribed sequence with moderate similarity to protein more 76.6(n)    BI868103.1 


    ENSEMBL Gene Tree for ANAPC16 (if available)
    TreeFam Gene Tree for ANAPC16 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ANAPC16 gene
    1 SIMAP similar gene for ANAPC16 using alignment to 1 protein entry:     APC16_HUMAN:
    C10orf104

    Find genes that share paralogs with ANAPC16           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ANAPC16 (see all 375)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1881081791,2
    --73978923(+) ACTGAC/TGGGAA 6 -- int10--------
    rs798150521,2
    C--73979085(+) GTGTAG/ATCCGG 6 -- int11Minor allele frequency- A:0.01NA 120
    rs1512990671,2
    --73979089(+) AGTCCA/GGAAGA 6 -- int10--------
    rs1808852891,2
    --73979127(+) GTTGCC/TTCTGT 6 -- int10--------
    rs1439376771,2
    C--73979265(+) GAGGT-/GGGA  
            
    GGATC
    6 -- int10--------
    rs1504713451,2
    --73979353(+) AGTGGA/GGTGTT 6 -- int10--------
    rs1383347891,2
    --73979364(+) CTGGCA/GCGTGC 6 -- int10--------
    rs1862957751,2
    --73979446(+) GCCAGA/GATAGT 6 -- int10--------
    rs1912718921,2
    --73979447(+) CCAGGA/GTAGTG 6 -- int10--------
    rs1835368251,2
    --73979493(+) CTGTCC/TCCAAA 6 -- int10--------

    HapMap Linkage Disequilibrium report for ANAPC16 (73975758 - 73995618 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for ANAPC16:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv269353CNV Insertion20981092
    nsv508592CNV Loss20534489
    nsv895721CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ANAPC16
    DNA2.0 Custom Variant and Variant Library Synthesis for ANAPC16

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 613427    OMIM disorders: --


    Find genes that share disorders with ANAPC16           About GenesLikeMe


    Export disorders for ANAPC16 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ANAPC16 gene, integrated from 10 sources (see all 20):
    (articles sorted by number of sources associating them with ANAPC16)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Systematic analysis of human protein complexes identifies chromosome segregation proteins. (PubMed id 20360068)1, 2, 3 Hutchins J.R.... Peters J.M. (Science 2010)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 3 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (Nature 2004)
    5. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    6. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (Sci Signal 2012)
    7. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    8. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    9. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    10. Lesson from the stoichiometry determination of the cohesin complex: a short protease mediated elution increases the recovery from cross-linked antibody-conjugated beads. (PubMed id 21043528)1 Holzmann J....Mechtler K. (J. Proteome Res. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 119504 HGNC: 26976 AceView: C10orf104 Ensembl:ENSG00000166295 euGenes: HUgn119504
    ECgene: ANAPC16 H-InvDB: ANAPC16

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ANAPC16 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ANAPC16 gene:
    Search GeneIP for patents involving ANAPC16

    GeneCards and IP:
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