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Aliases for ANAPC16 Gene

Aliases for ANAPC16 Gene

  • Anaphase Promoting Complex Subunit 16 2 3
  • C10orf104 3 4 6
  • Centromere Protein 27 2 3
  • Cyclosome Subunit 16 3 4
  • APC16 3 4
  • MSAG 3 6
  • Anaphase-Promoting Complex Subunit 16 3
  • Metabolic Syndrome-Associated Protein 3
  • Chromosome 10 Open Reading Frame 104 2
  • BA570G20.3 3
  • CENP-27 3

External Ids for ANAPC16 Gene

Previous HGNC Symbols for ANAPC16 Gene

  • C10orf104

Previous GeneCards Identifiers for ANAPC16 Gene

  • GC10P073975
  • GC10P067970

Summaries for ANAPC16 Gene

GeneCards Summary for ANAPC16 Gene

ANAPC16 (Anaphase Promoting Complex Subunit 16) is a Protein Coding gene.

UniProtKB/Swiss-Prot for ANAPC16 Gene

  • Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of Lys-11-linked polyubiquitin chains and, to a lower extent, the formation of Lys-48- and Lys-63-linked polyubiquitin chains.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANAPC16 Gene

Genomics for ANAPC16 Gene

Genomic Location for ANAPC16 Gene

Start:
72,216,000 bp from pter
End:
72,235,860 bp from pter
Size:
19,861 bases
Orientation:
Plus strand

Genomic View for ANAPC16 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ANAPC16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANAPC16 Gene

No data available for Regulatory Elements for ANAPC16 Gene

Proteins for ANAPC16 Gene

  • Protein details for ANAPC16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96DE5-APC16_HUMAN
    Recommended name:
    Anaphase-promoting complex subunit 16
    Protein Accession:
    Q96DE5
    Secondary Accessions:

    Protein attributes for ANAPC16 Gene

    Size:
    110 amino acids
    Molecular mass:
    11667 Da
    Quaternary structure:
    • The mammalian APC/C is composed of 14 distinct subunits that assemble into a complex of at least 19 chains with a combined molecular mass of around 1.2 MDa. ANAPC16 associates with the rest of the complex independently of ANAPC2 and ANAPC11.

    Three dimensional structures from OCA and Proteopedia for ANAPC16 Gene

neXtProt entry for ANAPC16 Gene

Proteomics data for ANAPC16 Gene at MOPED

Post-translational modifications for ANAPC16 Gene

  • Ubiquitination at Lys68
  • Modification sites at PhosphoSitePlus

Other Protein References for ANAPC16 Gene

No data available for DME Specific Peptides for ANAPC16 Gene

Domains for ANAPC16 Gene

Gene Families for ANAPC16 Gene

HGNC:
  • ANAPC :Anaphase promoting complex subunits

Protein Domains for ANAPC16 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ANAPC16 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96DE5

UniProtKB/Swiss-Prot:

APC16_HUMAN :
  • Q96DE5
Family:
  • Belongs to the APC16 family.
genes like me logo Genes that share domains with ANAPC16: view

Function for ANAPC16 Gene

Molecular function for ANAPC16 Gene

UniProtKB/Swiss-Prot Function: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of Lys-11-linked polyubiquitin chains and, to a lower extent, the formation of Lys-48- and Lys-63-linked polyubiquitin chains.

miRNA for ANAPC16 Gene

miRTarBase miRNAs that target ANAPC16

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ANAPC16 Gene

Localization for ANAPC16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ANAPC16 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ANAPC16 Gene COMPARTMENTS Subcellular localization image for ANAPC16 gene
Compartment Confidence
nucleus 5
cytosol 3
mitochondrion 1

Gene Ontology (GO) - Cellular Components for ANAPC16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005680 anaphase-promoting complex IDA 20360068
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with ANAPC16: view

Pathways for ANAPC16 Gene

SuperPathways for ANAPC16 Gene

No Data Available

UniProtKB/Swiss-Prot Q96DE5-APC16_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for ANAPC16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007067 mitotic nuclear division IEA --
GO:0016567 protein ubiquitination IEA --
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with ANAPC16: view

No data available for Pathways by source for ANAPC16 Gene

Transcripts for ANAPC16 Gene

Unigene Clusters for ANAPC16 Gene

Anaphase promoting complex subunit 16:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ANAPC16 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5a · 5b · 5c · 5d · 5e · 5f · 5g · 5h
SP1: - - - - - -
SP2: - - - - - - -
SP3: - - - - -
SP4: - - -
SP5: - - - - - - - -
SP6: - - - - - - - - -
SP7: - - - - - - -
SP8: - - - -
SP9: - -
SP10:
SP11: - - - -

Relevant External Links for ANAPC16 Gene

GeneLoc Exon Structure for
ANAPC16
ECgene alternative splicing isoforms for
ANAPC16

Expression for ANAPC16 Gene

mRNA expression in normal human tissues for ANAPC16 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ANAPC16 Gene

SOURCE GeneReport for Unigene cluster for ANAPC16 Gene Hs.426296

genes like me logo Genes that share expressions with ANAPC16: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ANAPC16 Gene

Orthologs for ANAPC16 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ANAPC16 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ANAPC16 35
  • 100 (n)
  • 100 (a)
ANAPC16 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ANAPC16 35
  • 94.24 (n)
  • 99.09 (a)
ANAPC16 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ANAPC16 35
  • 96.06 (n)
  • 100 (a)
ANAPC16 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Anapc16 35
  • 90 (n)
  • 100 (a)
Anapc16 16
Anapc16 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ANAPC16 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ANAPC16 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Anapc16 35
  • 91.21 (n)
  • 98.18 (a)
chicken
(Gallus gallus)
Aves ANAPC16 35
  • 82.12 (n)
  • 99.09 (a)
ANAPC16 36
  • 99 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ANAPC16 36
  • 96 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.7541 35
tropical clawed frog
(Silurana tropicalis)
Amphibia anapc16 35
  • 80.8 (n)
  • 94.57 (a)
Str.1888 35
zebrafish
(Danio rerio)
Actinopterygii anapc16 35
  • 75.56 (n)
  • 85.56 (a)
anapc16 36
  • 70 (a)
OneToOne
Dr.13949 35
Species with no ortholog for ANAPC16:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ANAPC16 Gene

ENSEMBL:
Gene Tree for ANAPC16 (if available)
TreeFam:
Gene Tree for ANAPC16 (if available)

Paralogs for ANAPC16 Gene

Selected SIMAP similar genes for ANAPC16 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ANAPC16: view

No data available for Paralogs for ANAPC16 Gene

Variants for ANAPC16 Gene

Sequence variations from dbSNP and Humsavar for ANAPC16 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs9275 -- 72,233,104(-) GAAGA(C/G/T)GGGGT synonymous-codon, reference, nc-transcript-variant
rs11952 -- 72,230,382(-) CAGAG(G/T)AATCT missense, reference, intron-variant, nc-transcript-variant
rs13980 -- 72,233,121(-) CCAGG(C/G/T)AGTAT utr-variant-3-prime, nc-transcript-variant
rs1136518 -- 72,233,302(+) GGAAT(A/G)TTTTG utr-variant-3-prime, nc-transcript-variant
rs4293052 -- 72,234,310(+) GCCAA(A/T)TTTTT utr-variant-3-prime, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for ANAPC16 Gene

Variant ID Type Subtype PubMed ID
nsv508592 CNV Loss 20534489
nsv895721 CNV Gain 21882294
esv269353 CNV Insertion 20981092

Relevant External Links for ANAPC16 Gene

HapMap Linkage Disequilibrium report
ANAPC16

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANAPC16 Gene

Disorders for ANAPC16 Gene

No disorders were found for ANAPC16 Gene.

No data available for UniProtKB/Swiss-Prot for ANAPC16 Gene

Publications for ANAPC16 Gene

  1. Systematic analysis of human protein complexes identifies chromosome segregation proteins. (PMID: 20360068) Hutchins J.R. … Peters J.M. (Science 2010) 2 3 4
  2. Molecular architecture and mechanism of the anaphase-promoting complex. (PMID: 25043029) Chang L. … Barford D. (Nature 2014) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 2 3
  4. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for ANAPC16 Gene

Sources for ANAPC16 Gene

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