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Aliases for ANAPC16 Gene

Aliases for ANAPC16 Gene

  • Anaphase Promoting Complex Subunit 16 2 3 5
  • Centromere Protein 27 2 3
  • Cyclosome Subunit 16 3 4
  • C10orf104 3 4
  • CENP-27 3 4
  • APC16 3 4
  • Anaphase-Promoting Complex Subunit 16 3
  • Metabolic Syndrome-Associated Protein 3
  • Chromosome 10 Open Reading Frame 104 2
  • BA570G20.3 3
  • MSAG 3

External Ids for ANAPC16 Gene

Previous HGNC Symbols for ANAPC16 Gene

  • C10orf104

Previous GeneCards Identifiers for ANAPC16 Gene

  • GC10P073975
  • GC10P067970
  • GC10P072217
  • GC10P072218

Summaries for ANAPC16 Gene

GeneCards Summary for ANAPC16 Gene

ANAPC16 (Anaphase Promoting Complex Subunit 16) is a Protein Coding gene. Among its related pathways are APC-Cdc20 mediated degradation of Nek2A and CDK-mediated phosphorylation and removal of Cdc6.

UniProtKB/Swiss-Prot for ANAPC16 Gene

  • Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of Lys-11-linked polyubiquitin chains and, to a lower extent, the formation of Lys-48- and Lys-63-linked polyubiquitin chains.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANAPC16 Gene

Genomics for ANAPC16 Gene

Regulatory Elements for ANAPC16 Gene

Enhancers for ANAPC16 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10G072241 2.3 VISTA FANTOM5 Ensembl ENCODE dbSUPER 12.3 +33.8 33801 16.8 MLX CREB3L1 DMAP1 YBX1 FEZF1 YY1 ZNF143 ZNF263 SP3 TBX21 ECD ASCC1 DNAJB12 DDIT4 DNAJC9 ENSG00000200170 ANAPC16 RPL17P50 ENSG00000272599 ENSG00000272630
GH10G072258 2.1 FANTOM5 Ensembl ENCODE dbSUPER 10.6 +45.8 45802 7.0 MLX CREB3L1 ZFP64 DMAP1 YBX1 FEZF1 YY1 SLC30A9 ZNF263 SP3 DNAJB12 C10orf105 ANAPC16 PSAP ASCC1 NUDT13 DNAJC9 DDIT4 VSIR GC10M072248
GH10G072307 2 FANTOM5 Ensembl ENCODE dbSUPER 11.1 +93.5 93498 3.8 HDGF PKNOX1 ARNT ARID4B ZNF766 CBX5 FOS KLF13 ZNF263 JUNB DNAJB12 DDIT4 ENSG00000200170 ASCC1 ANAPC16 PSAP ENSG00000269926
GH10G072314 2.1 FANTOM5 Ensembl ENCODE dbSUPER 10.5 +104.2 104225 11.7 MLX CREB3L1 FEZF1 DMAP1 YBX1 YY1 ZNF143 ZNF263 SP3 TBX21 DNAJB12 DDIT4 ECD PSAP ENSG00000227540 ANAPC16 NUDT13 MICU1 ENSG00000269926
GH10G072885 1.2 Ensembl ENCODE 14.5 +670.8 670828 3.5 PKNOX1 TCF12 ZNF766 FOS KLF13 ZNF263 CAVIN1 NCOA1 REST ZNF592 ANAPC16 DNAJB12 OIT3 ENSG00000272627
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ANAPC16 on UCSC Golden Path with GeneCards custom track

Promoters for ANAPC16 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000029690 200 1601 MLX CREB3L1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 TBX21 SSRP1

Genomic Location for ANAPC16 Gene

Chromosome:
10
Start:
72,216,000 bp from pter
End:
72,235,860 bp from pter
Size:
19,861 bases
Orientation:
Plus strand

Genomic View for ANAPC16 Gene

Genes around ANAPC16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANAPC16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANAPC16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANAPC16 Gene

Proteins for ANAPC16 Gene

  • Protein details for ANAPC16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96DE5-APC16_HUMAN
    Recommended name:
    Anaphase-promoting complex subunit 16
    Protein Accession:
    Q96DE5

    Protein attributes for ANAPC16 Gene

    Size:
    110 amino acids
    Molecular mass:
    11667 Da
    Quaternary structure:
    • The mammalian APC/C is composed of 14 distinct subunits that assemble into a complex of at least 19 chains with a combined molecular mass of around 1.2 MDa. ANAPC16 associates with the rest of the complex independently of ANAPC2 and ANAPC11.

    Three dimensional structures from OCA and Proteopedia for ANAPC16 Gene

neXtProt entry for ANAPC16 Gene

Post-translational modifications for ANAPC16 Gene

  • Ubiquitination at Lys68
  • Modification sites at PhosphoSitePlus

Other Protein References for ANAPC16 Gene

No data available for DME Specific Peptides for ANAPC16 Gene

Domains & Families for ANAPC16 Gene

Gene Families for ANAPC16 Gene

Protein Domains for ANAPC16 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ANAPC16 Gene

Graphical View of Domain Structure for InterPro Entry

Q96DE5

UniProtKB/Swiss-Prot:

APC16_HUMAN :
  • Belongs to the APC16 family.
Family:
  • Belongs to the APC16 family.
genes like me logo Genes that share domains with ANAPC16: view

Function for ANAPC16 Gene

Molecular function for ANAPC16 Gene

UniProtKB/Swiss-Prot Function:
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of Lys-11-linked polyubiquitin chains and, to a lower extent, the formation of Lys-48- and Lys-63-linked polyubiquitin chains.

Phenotypes for ANAPC16 Gene

genes like me logo Genes that share phenotypes with ANAPC16: view

Animal Model Products

CRISPR Products

miRNA for ANAPC16 Gene

miRTarBase miRNAs that target ANAPC16

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ANAPC16 Gene

Localization for ANAPC16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ANAPC16 Gene

Cytoplasm. Nucleus. Chromosome, centromere, kinetochore.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ANAPC16 gene
Compartment Confidence
nucleus 5
cytosol 5
mitochondrion 1

Gene Ontology (GO) - Cellular Components for ANAPC16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000776 kinetochore IEA,IDA 20813266
GO:0000777 condensed chromosome kinetochore IEA --
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005680 anaphase-promoting complex IDA 20360068
genes like me logo Genes that share ontologies with ANAPC16: view

Pathways & Interactions for ANAPC16 Gene

SuperPathways for ANAPC16 Gene

SuperPathway Contained pathways
1 CDK-mediated phosphorylation and removal of Cdc6
2 APC-Cdc20 mediated degradation of Nek2A
3 Cell Cycle, Mitotic
.60
4 Cellular Senescence
5 Mitotic Metaphase and Anaphase
genes like me logo Genes that share pathways with ANAPC16: view

UniProtKB/Swiss-Prot Q96DE5-APC16_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for ANAPC16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007049 cell cycle IEA --
GO:0007067 mitotic nuclear division IEA --
GO:0016567 protein ubiquitination IDA 20360068
GO:0031145 anaphase-promoting complex-dependent catabolic process TAS --
GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process TAS --
genes like me logo Genes that share ontologies with ANAPC16: view

No data available for SIGNOR curated interactions for ANAPC16 Gene

Drugs & Compounds for ANAPC16 Gene

(1) Drugs for ANAPC16 Gene - From: ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
TAME Pharma 0

(1) ApexBio Compounds for ANAPC16 Gene

Compound Action Cas Number
TAME 901-47-3
genes like me logo Genes that share compounds with ANAPC16: view

Drug Products

Transcripts for ANAPC16 Gene

Unigene Clusters for ANAPC16 Gene

Anaphase promoting complex subunit 16:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ANAPC16 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5a · 5b · 5c · 5d · 5e · 5f · 5g · 5h
SP1: - - - - - -
SP2: - - - - - - -
SP3: - - - - -
SP4: - - -
SP5: - - - - - - - -
SP6: - - - - - - - - -
SP7: - - - - - - -
SP8: - - - -
SP9: - -
SP10:
SP11: - - - -

Relevant External Links for ANAPC16 Gene

GeneLoc Exon Structure for
ANAPC16
ECgene alternative splicing isoforms for
ANAPC16

Expression for ANAPC16 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ANAPC16 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ANAPC16 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (38.0), Pancreas (18.2), and Breast (10.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ANAPC16 Gene



Protein tissue co-expression partners for ANAPC16 Gene

NURSA nuclear receptor signaling pathways regulating expression of ANAPC16 Gene:

ANAPC16

SOURCE GeneReport for Unigene cluster for ANAPC16 Gene:

Hs.426296

Evidence on tissue expression from TISSUES for ANAPC16 Gene

  • Lung(4.6)
  • Nervous system(3.3)
  • Heart(2)
  • Liver(2)
  • Muscle(2)
genes like me logo Genes that share expression patterns with ANAPC16: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ANAPC16 Gene

Orthologs for ANAPC16 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ANAPC16 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ANAPC16 34 35
  • 100 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ANAPC16 35
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ANAPC16 34 35
  • 96.06 (n)
cow
(Bos Taurus)
Mammalia ANAPC16 34 35
  • 94.24 (n)
rat
(Rattus norvegicus)
Mammalia Anapc16 34
  • 91.21 (n)
mouse
(Mus musculus)
Mammalia Anapc16 34 16 35
  • 90 (n)
oppossum
(Monodelphis domestica)
Mammalia ANAPC16 35
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves ANAPC16 34 35
  • 82.12 (n)
lizard
(Anolis carolinensis)
Reptilia ANAPC16 35
  • 96 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia anapc16 34
  • 80.8 (n)
Str.1888 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.7541 34
zebrafish
(Danio rerio)
Actinopterygii anapc16 34 35
  • 75.56 (n)
Dr.13949 34
Species where no ortholog for ANAPC16 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ANAPC16 Gene

ENSEMBL:
Gene Tree for ANAPC16 (if available)
TreeFam:
Gene Tree for ANAPC16 (if available)

Paralogs for ANAPC16 Gene

(1) SIMAP similar genes for ANAPC16 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ANAPC16: view

No data available for Paralogs for ANAPC16 Gene

Variants for ANAPC16 Gene

Sequence variations from dbSNP and Humsavar for ANAPC16 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1000040012 -- 72,214,339(+) TTCAG(C/T)GGTTA intron-variant, upstream-variant-2KB
rs1000266167 -- 72,220,050(+) CATGG(C/T)CAGGT intron-variant
rs1000437428 -- 72,225,755(+) AAATT(A/C)GCTGG intron-variant
rs1000556282 -- 72,225,474(+) CATTT(G/T)GGGAA intron-variant
rs1000652744 -- 72,231,961(+) ACGGG(C/T)GGATC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ANAPC16 Gene

Variant ID Type Subtype PubMed ID
esv3342969 CNV insertion 20981092
nsv1134027 CNV deletion 24896259
nsv1144501 CNV deletion 24896259
nsv508592 CNV deletion 20534489

Variation tolerance for ANAPC16 Gene

Residual Variation Intolerance Score: 65.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.22; 5.04% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ANAPC16 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ANAPC16

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANAPC16 Gene

Disorders for ANAPC16 Gene

Relevant External Links for ANAPC16

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ANAPC16

No disorders were found for ANAPC16 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANAPC16 Gene

Publications for ANAPC16 Gene

  1. Systematic analysis of human protein complexes identifies chromosome segregation proteins. (PMID: 20360068) Hutchins J.R. … Peters J.M. (Science 2010) 2 3 4 64
  2. Molecular architecture and mechanism of the anaphase-promoting complex. (PMID: 25043029) Chang L. … Barford D. (Nature 2014) 3 4 64
  3. The protein composition of mitotic chromosomes determined using multiclassifier combinatorial proteomics. (PMID: 20813266) Ohta S. … Rappsilber J. (Cell 2010) 3 4 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 2 3 64
  5. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 3 4 64

Products for ANAPC16 Gene

Sources for ANAPC16 Gene

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