Aliases for ANAPC15 Gene
Aliases for ANAPC15 Gene
External Ids for ANAPC15 Gene
- HGNC: 24531
- Entrez Gene: 25906
- Ensembl: ENSG00000110200
- OMIM: 614717
- UniProtKB: P60006
Previous HGNC Symbols for ANAPC15 Gene
- C11orf51
Previous GeneCards Identifiers for ANAPC15 Gene
- GC11M071817
Summaries for ANAPC15 Gene
GeneCards Summary for ANAPC15 Gene
ANAPC15 (Anaphase Promoting Complex Subunit 15) is a Protein Coding gene. Among its related pathways are Regulation of activated PAK-2p34 by proteasome mediated degradation and Mitotic Metaphase and Anaphase.
UniProtKB/Swiss-Prot for ANAPC15 Gene
-
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. In the complex, plays a role in the release of the mitotic checkpoint complex (MCC) from the APC/C: not required for APC/C activity itself, but promotes the turnover of CDC20 and MCC on the APC/C, thereby participating in the responsiveness of the spindle assembly checkpoint. Also required for degradation of CDC20.
No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANAPC15 Gene
Genomics for ANAPC15 Gene
Regulatory Elements for ANAPC15 Gene
Enhancers for ANAPC15 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around ANAPC15 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for ANAPC15 Gene
- Chromosome:
- 11
- Start:
- 72,106,378 bp from pter
- End:
- 72,112,780 bp from pter
- Size:
- 6,403 bases
- Orientation:
- Minus strand
Genomic View for ANAPC15 Gene
Genes around ANAPC15 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11q13.4 by Ensembl
- 11q13.4 by Entrez Gene
- 11q13.4 by HGNC
ANAPC15 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ANAPC15 Gene
Proteins for ANAPC15 Gene
-
Protein details for ANAPC15 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P60006-APC15_HUMAN
- Recommended name:
- Anaphase-promoting complex subunit 15
- Protein Accession:
- P60006
- G3V1Q3
- Q9CXK2
- Q9Y269
Protein attributes for ANAPC15 Gene
- Size:
- 121 amino acids
- Molecular mass:
- 14281 Da
- Quaternary structure:
-
- The mammalian APC/C is composed of 14 distinct subunits that assemble into a complex of at least 19 chains with a combined molecular mass of around 1.2 MDa.
- SequenceCaution:
-
- Sequence=EAW74842.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
Three dimensional structures from OCA and Proteopedia for ANAPC15 Gene
Protein Expression for ANAPC15 Gene
Post-translational modifications for ANAPC15 Gene
No Post-translational modifications
Other Protein References for ANAPC15 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
-
- NP_001265414.1
- NP_001265415.1
- NP_001265416.1
- NP_001265417.1
- NP_001265418.1
- NP_001265419.1
- NP_001265420.1
- NP_001265421.1
- NP_001265422.1
- NP_001265423.1
- NP_001317250.1
- NP_054761.1
- XP_016872977.1
- XP_016872978.1
- XP_016872979.1
- XP_016872980.1
- XP_016872981.1
- XP_016872982.1
- XP_016872983.1
- XP_016872984.1
- XP_016872985.1
- XP_016872986.1
Antibody Products
- Novus Biologicals Antibodies for ANAPC15
- Invitrogen Antibodies for ANAPC15
- antibodies-online Antibodies for ANAPC15: See all 6
- Search GeneTex for Antibodies for ANAPC15
-
Santa Cruz Biotechnology (SCBT) Antibodies for ANAPC15
Protein Products
-
OriGene Purified Proteins for ANAPC15
- Search Origene for MassSpec and Protein Over-expression Lysates for ANAPC15
- Origene Custom Protein Services for ANAPC15
- antibodies-online Proteins for ANAPC15: See all 4
- Search antibodies-online for peptides
- Search GeneTex for Proteins for ANAPC15
Assay Products
No data available for DME Specific Peptides for ANAPC15 Gene
Domains & Families for ANAPC15 Gene
Gene Families for ANAPC15 Gene
Graphical View of Domain Structure for InterPro Entry
P60006- Family:
-
- Belongs to the APC15 family.
No data available for Suggested Antigen Peptide Sequences for ANAPC15 Gene
Function for ANAPC15 Gene
Molecular function for ANAPC15 Gene
- UniProtKB/Swiss-Prot Function:
- Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. In the complex, plays a role in the release of the mitotic checkpoint complex (MCC) from the APC/C: not required for APC/C activity itself, but promotes the turnover of CDC20 and MCC on the APC/C, thereby participating in the responsiveness of the spindle assembly checkpoint. Also required for degradation of CDC20.
Phenotypes for ANAPC15 Gene
- GenomeRNAi human phenotypes for ANAPC15:
Animal Model Products
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-
-
ViGene Biosciences lentiviral particle packaged cDNA for ANAPC15 gene
-
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- Search ViGene Biosciences for ANAPC15
CRISPR Products
-
OriGene CRISPR knockouts for ANAPC15
- GenScript: Design CRISPR guide RNA sequences for ANAPC15
miRNA for ANAPC15 Gene
- miRTarBase miRNAs that target ANAPC15
miRNA Products
- Search ViGene Biosciences for ANAPC15
Inhibitory RNA Products
- Origene shRNA, siRNA, mouse_rna, and RNAi products in human, mouse, rat for ANAPC15
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-
ViGene Biosciences ready-to-package AAV shRNAs for ANAPC15 gene
Clone Products
- Sino Biological Human cDNA Clone for ANAPC15
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- Addgene plasmids for ANAPC15
- VectorBuilder custom plasmid, inducible vectors for ANAPC15
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ANAPC15
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for ANAPC15
-
ViGene Biosciences adenoviral particle packaged cDNA for ANAPC15 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for ANAPC15 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for ANAPC15 gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ANAPC15 Gene
Localization for ANAPC15 Gene
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| extracellular | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005622 | intracellular | IDA | -- |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005680 | anaphase-promoting complex | IEA,IDA | 21926987 |
| GO:0005829 | cytosol | TAS | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for ANAPC15 Gene
Pathways & Interactions for ANAPC15 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Regulation of activated PAK-2p34 by proteasome mediated degradation | ||
| 2 | APC-Cdc20 mediated degradation of Nek2A | ||
| 3 | Cell Cycle, Mitotic |
.83
|
.60
|
| 4 | Cellular Senescence | ||
| 5 | Mitotic Metaphase and Anaphase |
.94
|
|
Pathways by source for ANAPC15 Gene
1 Sino Biological pathway for ANAPC15 Gene
27 Reactome pathways for ANAPC15 Gene
- Activation of APC/C and APC/C-Cdc20 mediated degradation of mitotic proteins
- APC/C-Cdc20 mediated degradation of Cyclin B
- APC/C-Cdc20 mediated degradation of mitotic proteins
- APC/C-Cdc20 mediated degradation of Securin
- APC/C-Cdh1 mediated degradation of Cdc20 and other APC/C-Cdh1 targeted proteins in late mitosis/early G1
Interacting Proteins for ANAPC15 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007049 | cell cycle | IEA | -- |
| GO:0007067 | mitotic nuclear division | IEA | -- |
| GO:0031145 | anaphase-promoting complex-dependent catabolic process | TAS | -- |
| GO:0042787 | protein ubiquitination involved in ubiquitin-dependent protein catabolic process | TAS | -- |
| GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process | TAS | -- |
No data available for SIGNOR curated interactions for ANAPC15 Gene
Drugs & Compounds for ANAPC15 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| TAME | Pharma | 0 |
(1) ApexBio Compounds for ANAPC15 Gene
| Compound | Action | Cas Number |
|---|---|---|
| TAME | 901-47-3 |
Drug Products
- ApexBio compounds for ANAPC15
Transcripts for ANAPC15 Gene
mRNA/cDNA for ANAPC15 Gene
- (22) REFSEQ mRNAs :
- (6) Additional mRNA sequences :
- (593) Selected AceView cDNA sequences:
- (17) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for ANAPC15 Gene
CRISPR Products
-
OriGene CRISPR knockouts for ANAPC15
- GenScript: Design CRISPR guide RNA sequences for ANAPC15
miRNA Products
- Search ViGene Biosciences for ANAPC15
Inhibitory RNA Products
- Origene shRNA, siRNA, mouse_rna, and RNAi products in human, mouse, rat for ANAPC15
- Browse OriGene Inhibitory RNA Products For ANAPC15
-
ViGene Biosciences ready-to-package AAV shRNAs for ANAPC15 gene
Clone Products
- Sino Biological Human cDNA Clone for ANAPC15
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for ANAPC15
- VectorBuilder custom plasmid, inducible vectors for ANAPC15
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ANAPC15
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | · | 7c | · | 7d | · | 7e | ^ | 8 | ^ | 9 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||||||||||
| SP4: | - | - | |||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | ||||||||||||||||||||||||
| SP6: |
Expression for ANAPC15 Gene
This gene is overexpressed in Pancreas (46.0) and Fetal ovary (19.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ANAPC15 Gene
NURSA nuclear receptor signaling pathways regulating expression of ANAPC15 Gene:
ANAPC15SOURCE GeneReport for Unigene cluster for ANAPC15 Gene:
Hs.38044Primer Products
-
OriGene qPCR primer pairs and template standards for ANAPC15
-
OriGene qPCR primer pairs for ANAPC15
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ANAPC15 Gene
Orthologs for ANAPC15 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| cow (Bos Taurus) |
Mammalia | ANAPC15 35 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | ANAPC15 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Anapc15 35 |
|
OneToMany | |
| Anapc15-ps 35 |
|
OneToMany | |||
| oppossum (Monodelphis domestica) |
Mammalia | ANAPC15 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | ANAPC15 35 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | ANAPC15 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | Str.6387 34 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.6427 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | anapc15 35 |
|
OneToOne | |
| Dr.13292 34 |
|
- Species where no ortholog for ANAPC15 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chimpanzee (Pan troglodytes)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for ANAPC15 Gene
Pseudogenes.org Pseudogenes for ANAPC15 Gene
No data available for Paralogs for ANAPC15 Gene
Variants for ANAPC15 Gene
| SNP ID | Clin | Chr 11 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs137853185 | Pathogenic | 72,106,094(+) | GGAGC(A/G)GGCCT | downstream-variant-500B, reference, missense | |
| rs137853186 | Pathogenic | 72,106,165(+) | ACCAC(C/T)GGAGC | downstream-variant-500B, reference, missense | |
| rs137853187 | Pathogenic | 72,106,180(+) | GCTGC(A/G)AGTAC | downstream-variant-500B, reference, missense | |
| rs137853188 | Pathogenic | 72,106,185(+) | GAGTA(C/G)TTGAG | downstream-variant-500B, reference, stop-gained | |
| rs545947177 | Pathogenic | 72,106,214(+) | AGGTC(A/C)GTGTT | intron-variant, downstream-variant-500B |
Residual Variation Intolerance Score:
42.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.19;
4.30% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for ANAPC15 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- ANAPC15
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ANAPC15 Gene
Disorders for ANAPC15 Gene
Relevant External Links for ANAPC15
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- ANAPC15
No disorders were found for ANAPC15 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANAPC15 Gene
Publications for ANAPC15 Gene
- APC15 drives the turnover of MCC-CDC20 to make the spindle assembly checkpoint responsive to kinetochore attachment. (PMID: 21926987) Mansfeld J. … Pines J. (Nat. Cell Biol. 2011) 2 3 4 64
- Molecular architecture and mechanism of the anaphase-promoting complex. (PMID: 25043029) Chang L. … Barford D. (Nature 2014) 3 4 64
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
- Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4 64
- Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 3 4 64
Products for ANAPC15 Gene
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- ViGene Biosciences adenoviral particle packaged cDNA for ANAPC15 gene
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- Horizon Cell Lines for ANAPC15
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- VectorBuilder custom plasmid, inducible vectors for ANAPC15
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ANAPC15
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for ANAPC15 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
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- (146) Cyagen
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