ANAPC15 Gene
protein-coding GIFtS: 37
GCID: GC11M071817
|
|
anaphase promoting complex subunit 15(Previous name: chromosome 11 open reading frame 51 )
(Previous symbol: C11orf51)
| |
Aliases
for ANAPC15 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Anaphase Promoting Complex Subunit 151 2 | | HSPC0201 | | APC151 2 3 | | Chromosome 11 Open Reading Frame 511 | | C11orf511 2 3 | | Anaphase-Promoting Complex Subunit 152 | | DKFZP564M0821 | | |
Export aliases for ANAPC15 gene to outside databases |
Summaries
for ANAPC15 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: APC15_HUMAN, P60006Function: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligasethat controls progression through mitosis and the G1 phase of the cell cycle. In the complex, plays a role in therelease of the mitotic checkpoint complex (MCC) from the APC/C: not required for APC/C activity itself, but promotesthe turnover of CDC20 and MCC on the APC/C, thereby participating to the responsiveness of the spindle assemblycheckpoint. Also required for degradation of CDC20
|
Genomic Views
for ANAPC15 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_167190.1
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for ANAPC15
Other transcription factors
Search SABiosciences Chromatin IP Primers for ANAPC15
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ANAPC15 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11q13.4 Ensembl cytogenetic band: 11q13.4 HGNC cytogenetic band: 11q13.4ANAPC15 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11M071817: view genomic region
(about GC identifiers)
Start:
|
71,817,424 bp from pter |
End:
|
71,823,826 bp from pter |
Size:
|
6,403 bases |
Orientation:
|
minus strand |
|
Proteins
for ANAPC15 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: APC15_HUMAN, P60006 (See
protein sequence)Recommended Name: Anaphase-promoting complex subunit 15 Size: 121 amino acids; 14281 Da
Subunit: The APC/C is composed of at least 12 subunits
Sequence caution: Sequence=EAW74842.1; Type=Erroneous gene model prediction;
Secondary accessions: G3V1Q3 Q9CXK2 Q9Y269Explore the universe of human proteins at neXtProt for ANAPC15: NX_P60006
ANAPC15 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_054761.1
ENSEMBL proteins: ENSP00000441774 ENSP00000437360 ENSP00000445212 ENSP00000439403 ENSP00000443645 ENSP00000227618 ENSP00000443911 ENSP00000446412 ENSP00000446383 ENSP00000440002 ENSP00000443383 ENSP00000440983 ENSP00000437683 ENSP00000389730 ENSP00000439362 ENSP00000440380
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005622 | intracellular |
IDA | -- | | GO:0005680 | anaphase-promoting complex |
IDA | -- |
ANAPC15 for ontologies About GeneDecksing
ANAPC15 Antibody Products:
Assay Products for ANAPC15: |
Protein
Domains /
Families
for ANAPC15 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ANAPC15 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry P60006ProtoNet protein and cluster: P60006 UniProtKB/Swiss-Prot: APC15_HUMAN, P60006Similarity: Belongs to the APC15 family |
Function
for ANAPC15 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: APC15_HUMAN, P60006Function: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligasethat controls progression through mitosis and the G1 phase of the cell cycle. In the complex, plays a role in therelease of the mitotic checkpoint complex (MCC) from the APC/C: not required for APC/C activity itself, but promotesthe turnover of CDC20 and MCC on the APC/C, thereby participating to the responsiveness of the spindle assemblycheckpoint. Also required for degradation of CDC20
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ANAPC15 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ANAPC15
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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Synthesis Service for ANAPC15 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ANAPC15 |
3 GenomeRNAi human phenotypes for ANAPC15:
|
Pathways & Interactions
for ANAPC15 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ANAPC15
STRING Interaction
Network Preview (showing 5 interactants - click image to see 22)
5/22 Interacting proteins for ANAPC15 (ENSP000002276184) via UniProtKB, MINT, STRING, and/or I2D (see all 22)About this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007067 | mitosis |
IEA | -- | | GO:0051301 | cell division |
IEA | -- | | GO:0090266 | regulation of mitotic cell cycle spindle assembly checkpoint |
IMP | -- |
ANAPC15 for ontologies About GeneDecksing
|
Drugs & Compounds
for ANAPC15 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ANAPC15
Search CenterWatch for drugs/clinical trials and news about ANAPC15 / APC15
|
Transcripts
for ANAPC15 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ANAPC15 gene: NM_014042.2 Unigene Cluster for ANAPC15: Anaphase promoting complex subunit 15 Hs.38044 [show with all ESTs]Unigene Representative Sequence: AK31114617 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000502597(uc009ytc.1) ENST00000543050 ENST00000538117 ENST00000543587(uc001orv.3)
ENST00000543015 ENST00000545680 ENST00000227618(uc001orw.3) ENST00000542531
ENST00000535234 ENST00000545944 ENST00000538393 ENST00000535503 ENST00000538919
ENST00000537644 ENST00000438939 ENST00000545333 ENST00000539395
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ANAPC15 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ANAPC15
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript Custom all cDNA clones Services for ANAPC15 | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ANAPC15 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ANAPC15 |
Additional cDNA sequence: AF077206.1 AK222622.1 AK311146.1 AL080071.1 BC005156.2 BC005393.1 12 DOTS entries: DT.91640431 DT.102824953 DT.120712088 DT.85105330 DT.120711959 DT.97843177 DT.120711949 DT.85105329 DT.95233089 DT.120712098 DT.121281162 DT.92473190 24/593 AceView cDNA sequences (see all 593): BM973912 BU857057 CB142202 BM987519 BM762310 BM744923 AI676075 BM762263 BG231826 BM755811 AA846012 D56195 CR603805 BM974658 BU784910 BQ064820 AA505892 AA768979 AI095684 CR613122 BX384580 CR626401 AI138427 BQ056214
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for ANAPC15 (see all 6) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | · | 7c | · | 7d | · | 7e | ^ | 8 | ^ | 9 |
|---|
|
| SP1: | | | | | - | | | | - | | | | | | | | - | | | | | | | | | | | | | | |
| SP2: | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | - | | | | | | | | | | | | - | | | | | | | | | | | | | | |
| SP4: | | | | | - | | | | | | | | | | | | - | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | - | | - | | - | | - | | - | | | | | |
ECgene alternative splicing isoforms for ANAPC15
|
Expression
for ANAPC15 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| See probesets specificity/sensitivity at GeneAnnot
CGAP TAG: --
See ANAPC15 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ANAPC15
SOURCE GeneReport for Unigene cluster: Hs.38044
SABiosciences Custom PCR Arrays for ANAPC15
Primer
Products: | | Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat ANAPC15 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ANAPC15 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ANAPC15 |
Orthologs
for ANAPC15 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for ANAPC15 gene from 6/14 species (see all 14) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Anapc151 , 5 |
RIKEN cDNA 3200002M19 gene5
anaphase prompoting complex C subunit 151 |
94.21(n)1
100(a)1 |
|
7 (54.68 cM)5
754301 NM_027532.31 NP_081808.21
1018813255 |
chicken
(Gallus gallus) |
Aves |
LOC1008574051 |
uncharacterized LOC100857405 |
83.75(n)
94.21(a) |
|
100857405 XM_003643434.1 XP_003643482.1 |
lizard
(Anolis carolinensis) |
Reptilia |
C11orf516 |
-- |
81(a) |
1 ↔ 1 |
GL343792.1(11359-21083) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.64272 |
Xenopus laevis transcribed sequence with moderate similarity more |
80.17(n) |
|
48058459 |
zebrafish
(Danio rerio) |
Actinopterygii |
Dr.132922 |
Transcribed sequence with moderate similarity to protein more |
83.5(n) |
|
BI672822.1 |
honey bee
(Apis mellifera) |
Insecta |
-- |
-- |
42(a) |
1 ↔ 1 |
Group3.25(134401-134693) |
ENSEMBL Gene Tree for ANAPC15 (if available)
TreeFam Gene Tree for ANAPC15 (if available) |
Paralogs
for ANAPC15 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ANAPC15 gene
ANAPC15 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for ANAPC15
PGOHUM00000241182
|
Genomic Variants
for ANAPC15 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ANAPC15 (71817424 - 71823826 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ANAPC15: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ANAPC15 |
|
Disorders
/ Diseases
for ANAPC15 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 ANAPC15 for disorders About MalaCards
ANAPC15 for disorders About GeneDecksing
OMIM gene information: 614717
OMIM disorders: --
Export disorders for ANAPC15 gene to outside databases
|
Publications
for ANAPC15 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ANAPC15 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ANAPC15) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- APC15 drives the turnover of MCC-CDC20 to make the sp indle assembly checkpoint responsive to kinetochore attachment. (PubMed id 21926987)1, 2, 3 Mansfeld J....Pines J. (2011)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (2001)
- Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2 Zhang Q.-H.... Chen Z. (2000)
- APC15 mediates CDC20 autoubiquitylation by APC/C(MCC) and disassembly of the mitotic checkpoint complex. (PubMed id 23007861)1 Uzunova K....Peters J.M. (2012)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)2 Taylor T.D....Sakaki Y. (2006)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. (PubMed id 11256614)1 Simpson J.C.... Wiemann S. (2000)
- Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PubMed id 8125298)1 Maruyama K. and Sugano S. (1994)
|
External Searches for ANAPC15 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ANAPC15 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ANAPC15 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ANAPC15 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ANAPC15 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ANAPC15 gene:
Search GeneIP for patents involving ANAPC15
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ANAPC15 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 |
| | | | |
 |
 |
|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ANAPC15 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ANAPC15 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ANAPC15 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ANAPC15 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ANAPC15 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ANAPC15 |
| |
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| | | | Search Tocris compounds for ANAPC15 |
| |  |  |  |  | | | | |
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 | | | ANAPC15 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | ThermoFisher Antibodies for ANAPC15 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ANAPC15 |
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