Aliases for ANAPC15 Gene
Aliases for ANAPC15 Gene
External Ids for ANAPC15 Gene
- HGNC: 24531
- Entrez Gene: 25906
- Ensembl: ENSG00000110200
- OMIM: 614717
- UniProtKB: P60006
Previous HGNC Symbols for ANAPC15 Gene
- C11orf51
Previous GeneCards Identifiers for ANAPC15 Gene
- GC11M071817
Summaries for ANAPC15 Gene
GeneCards Summary for ANAPC15 Gene
ANAPC15 (Anaphase Promoting Complex Subunit 15) is a Protein Coding gene. Among its related pathways are Cellular Senescence (REACTOME) and CDK-mediated phosphorylation and removal of Cdc6.
UniProtKB/Swiss-Prot for ANAPC15 Gene
-
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. In the complex, plays a role in the release of the mitotic checkpoint complex (MCC) from the APC/C: not required for APC/C activity itself, but promotes the turnover of CDC20 and MCC on the APC/C, thereby participating in the responsiveness of the spindle assembly checkpoint. Also required for degradation of CDC20.
Additional gene information for ANAPC15 Gene
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANAPC15 Gene
Genomics for ANAPC15 Gene
GeneHancer (GH) Regulatory Elements for ANAPC15 Gene
Promoters and enhancers for ANAPC15 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around ANAPC15 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for ANAPC15 Gene
Genomic Locations for ANAPC15 Gene
- chr11:72,106,378-72,112,780
- (GRCh38/hg38)
- Size:
- 6,403 bases
- Orientation:
- Minus strand
- chr11:71,817,424-71,823,826
- (GRCh37/hg19)
Genomic View for ANAPC15 Gene
Genes around ANAPC15 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11q13.4 by Ensembl
- 11q13.4 by Entrez Gene
- 11q13.4 by HGNC
ANAPC15 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ANAPC15 Gene
Proteins for ANAPC15 Gene
-
Protein details for ANAPC15 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P60006-APC15_HUMAN
- Recommended name:
- Anaphase-promoting complex subunit 15
- Protein Accession:
- P60006
- G3V1Q3
- Q9CXK2
- Q9Y269
Protein attributes for ANAPC15 Gene
- Size:
- 121 amino acids
- Molecular mass:
- 14281 Da
- Quaternary structure:
-
- The mammalian APC/C is composed of 14 distinct subunits that assemble into a complex of at least 19 chains with a combined molecular mass of around 1.2 MDa.
- SequenceCaution:
-
- Sequence=EAW74842.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
Three dimensional structures from OCA and Proteopedia for ANAPC15 Gene
Protein Expression for ANAPC15 Gene
Post-translational modifications for ANAPC15 Gene
No Post-translational modifications
Other Protein References for ANAPC15 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
-
- NP_001265414.1
- NP_001265415.1
- NP_001265416.1
- NP_001265417.1
- NP_001265418.1
- NP_001265419.1
- NP_001265420.1
- NP_001265421.1
- NP_001265422.1
- NP_001265423.1
- NP_001317250.1
- NP_054761.1
- XP_016872977.1
- XP_016872978.1
- XP_016872979.1
- XP_016872980.1
- XP_016872981.1
- XP_016872982.1
- XP_016872983.1
- XP_016872984.1
- XP_016872985.1
- XP_016872986.1
Antibody Products
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Assay Products
No data available for DME Specific Peptides for ANAPC15 Gene
Domains & Families for ANAPC15 Gene
Gene Families for ANAPC15 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Graphical View of Domain Structure for InterPro Entry
P60006- Family:
-
- Belongs to the APC15 family.
No data available for Suggested Antigen Peptide Sequences for ANAPC15 Gene
Function for ANAPC15 Gene
Molecular function for ANAPC15 Gene
- UniProtKB/Swiss-Prot Function:
- Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. In the complex, plays a role in the release of the mitotic checkpoint complex (MCC) from the APC/C: not required for APC/C activity itself, but promotes the turnover of CDC20 and MCC on the APC/C, thereby participating in the responsiveness of the spindle assembly checkpoint. Also required for degradation of CDC20.
Phenotypes for ANAPC15 Gene
- GenomeRNAi human phenotypes for ANAPC15:
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-
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miRNA for ANAPC15 Gene
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-
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- Mammalian expression: PiggyBac
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- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
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-
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Cell Line Products
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No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ANAPC15 Gene
Localization for ANAPC15 Gene
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| extracellular | 1 |
- Nucleoplasm (2)
- Vesicles (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005622 | intracellular | IDA | -- |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005680 | anaphase-promoting complex | IEA,IDA | 21926987 |
| GO:0005829 | cytosol | TAS | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for ANAPC15 Gene
Pathways & Interactions for ANAPC15 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | CDK-mediated phosphorylation and removal of Cdc6 | ||
| 2 | APC-Cdc20 mediated degradation of Nek2A | ||
| 3 | Cell Cycle, Mitotic |
.83
|
.60
|
| 4 | Cellular Senescence (REACTOME) | ||
| 5 | Mitotic Metaphase and Anaphase |
.94
|
|
Pathways by source for ANAPC15 Gene
1 Sino Biological pathway for ANAPC15 Gene
27 Reactome pathways for ANAPC15 Gene
- Activation of APC/C and APC/C-Cdc20 mediated degradation of mitotic proteins
- APC/C-Cdc20 mediated degradation of Cyclin B
- APC/C-Cdc20 mediated degradation of mitotic proteins
- APC/C-Cdc20 mediated degradation of Securin
- APC/C-Cdh1 mediated degradation of Cdc20 and other APC/C-Cdh1 targeted proteins in late mitosis/early G1
Interacting Proteins for ANAPC15 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007049 | cell cycle | IEA | -- |
| GO:0031145 | anaphase-promoting complex-dependent catabolic process | TAS | -- |
| GO:0042787 | protein ubiquitination involved in ubiquitin-dependent protein catabolic process | TAS | -- |
| GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process | TAS | -- |
| GO:0051301 | cell division | IEA | -- |
No data available for SIGNOR curated interactions for ANAPC15 Gene
Drugs & Compounds for ANAPC15 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| TAME | Pharma | 0 |
(1) ApexBio Compounds for ANAPC15 Gene
| Compound | Action | Cas Number |
|---|---|---|
| TAME | 901-47-3 |
Transcripts for ANAPC15 Gene
mRNA/cDNA for ANAPC15 Gene
- (22) REFSEQ mRNAs :
- (6) Additional mRNA sequences :
- (593) Selected AceView cDNA sequences:
- (17) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for ANAPC15 Gene
CRISPR Products
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OriGene CRISPR knockouts for ANAPC15
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Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ANAPC15
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miRNA Products
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Inhibitory RNA Products
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Clone Products
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- VectorBuilder custom plasmid, inducible vectors for ANAPC15
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ANAPC15
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for ANAPC15
- genomics-online: cdna clones - Search results for available ANAPC15 gene related products
- orf clones - Search results for available ANAPC15 gene related products
- Applied Biological Materials Clones for ANAPC15
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | · | 7c | · | 7d | · | 7e | ^ | 8 | ^ | 9 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||||||||||
| SP4: | - | - | |||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | ||||||||||||||||||||||||
| SP6: |
Expression for ANAPC15 Gene
This gene is overexpressed in Pancreas (46.0) and Fetal ovary (19.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ANAPC15 Gene
NURSA nuclear receptor signaling pathways regulating expression of ANAPC15 Gene:
ANAPC15SOURCE GeneReport for Unigene cluster for ANAPC15 Gene:
Hs.38044Evidence on tissue expression from TISSUES for ANAPC15 Gene
- Kidney(4.3)
- Muscle(4.3)
- Nervous system(4.2)
- Blood(4)
Primer Products
-
OriGene qPCR primer pairs and template standards for ANAPC15
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No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ANAPC15 Gene
Orthologs for ANAPC15 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| cow (Bos Taurus) |
Mammalia | ANAPC15 34 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | ANAPC15 33 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Anapc15 34 |
|
OneToMany | |
| Anapc15-ps 34 |
|
OneToMany | |||
| oppossum (Monodelphis domestica) |
Mammalia | ANAPC15 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | ANAPC15 34 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | ANAPC15 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | Str.6387 33 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.6427 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | anapc15 34 |
|
OneToOne | |
| Dr.13292 33 |
|
- Species where no ortholog for ANAPC15 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chimpanzee (Pan troglodytes)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for ANAPC15 Gene
Pseudogenes.org Pseudogenes for ANAPC15 Gene
No data available for Paralogs for ANAPC15 Gene
Variants for ANAPC15 Gene
| SNP ID | Clin | Chr 11 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1025935979 | uncertain-significance, Nonsyndromic Hearing Loss, Recessive | 72,108,829(-) | T/G | genic_downstream_transcript_variant, intron_variant | |
| rs113912971 | uncertain-significance, Nonsyndromic Hearing Loss, Recessive | 72,109,802(-) | T/C | 3_prime_UTR_variant, intron_variant | |
| rs116397624 | uncertain-significance, Nonsyndromic Hearing Loss, Recessive | 72,109,526(-) | A/C/T | downstream_transcript_variant, genic_downstream_transcript_variant, intron_variant | |
| rs137853185 | pathogenic, Deafness, autosomal recessive 63 | 72,106,094(-) | G/A | downstream_transcript_variant | |
| rs137853186 | pathogenic, Deafness, autosomal recessive 63 | 72,106,165(-) | T/C | downstream_transcript_variant |
Residual Variation Intolerance Score:
42.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.19;
4.30% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ANAPC15 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- ANAPC15
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ANAPC15 Gene
Disorders for ANAPC15 Gene
Additional Disease Information for ANAPC15
No disorders were found for ANAPC15 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANAPC15 Gene
Publications for ANAPC15 Gene
- APC15 drives the turnover of MCC-CDC20 to make the spindle assembly checkpoint responsive to kinetochore attachment. (PMID: 21926987) Mansfeld J … Pines J (Nature cell biology 2011) 2 3 4 58
- Molecular architecture and mechanism of the anaphase-promoting complex. (PMID: 25043029) Chang LF … Barford D (Nature 2014) 3 4 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
- Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 3 4 58
- Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang QH … Chen Z (Genome research 2000) 3 4 58
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for ANAPC15
- antibodies-online: Search results for 7 available ANAPC15 Antibodies ranked by validation data
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Sources for ANAPC15 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
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