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Aliases for ANAPC15 Gene

Aliases for ANAPC15 Gene

  • Anaphase Promoting Complex Subunit 15 2 3 5
  • C11orf51 3 4
  • APC15 3 4
  • Chromosome 11 Open Reading Frame 51 2
  • HSPC020 3

External Ids for ANAPC15 Gene

Previous HGNC Symbols for ANAPC15 Gene

  • C11orf51

Previous GeneCards Identifiers for ANAPC15 Gene

  • GC11M071817

Summaries for ANAPC15 Gene

GeneCards Summary for ANAPC15 Gene

ANAPC15 (Anaphase Promoting Complex Subunit 15) is a Protein Coding gene. Among its related pathways are Cellular Senescence and Cell Cycle, Mitotic.

UniProtKB/Swiss-Prot for ANAPC15 Gene

  • Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. In the complex, plays a role in the release of the mitotic checkpoint complex (MCC) from the APC/C: not required for APC/C activity itself, but promotes the turnover of CDC20 and MCC on the APC/C, thereby participating in the responsiveness of the spindle assembly checkpoint. Also required for degradation of CDC20.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANAPC15 Gene

Genomics for ANAPC15 Gene

Regulatory Elements for ANAPC15 Gene

Promoters for ANAPC15 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ANAPC15 on UCSC Golden Path with GeneCards custom track

Genomic Location for ANAPC15 Gene

Chromosome:
11
Start:
72,106,378 bp from pter
End:
72,112,780 bp from pter
Size:
6,403 bases
Orientation:
Minus strand

Genomic View for ANAPC15 Gene

Genes around ANAPC15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANAPC15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANAPC15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANAPC15 Gene

Proteins for ANAPC15 Gene

  • Protein details for ANAPC15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P60006-APC15_HUMAN
    Recommended name:
    Anaphase-promoting complex subunit 15
    Protein Accession:
    P60006
    Secondary Accessions:
    • G3V1Q3
    • Q9CXK2
    • Q9Y269

    Protein attributes for ANAPC15 Gene

    Size:
    121 amino acids
    Molecular mass:
    14281 Da
    Quaternary structure:
    • The mammalian APC/C is composed of 14 distinct subunits that assemble into a complex of at least 19 chains with a combined molecular mass of around 1.2 MDa.
    SequenceCaution:
    • Sequence=EAW74842.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ANAPC15 Gene

    Alternative splice isoforms for ANAPC15 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ANAPC15 Gene

Proteomics data for ANAPC15 Gene at MOPED

Post-translational modifications for ANAPC15 Gene

No Post-translational modifications

Antibody Products

No data available for DME Specific Peptides for ANAPC15 Gene

Domains & Families for ANAPC15 Gene

Gene Families for ANAPC15 Gene

Protein Domains for ANAPC15 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

P60006

UniProtKB/Swiss-Prot:

APC15_HUMAN :
  • Belongs to the APC15 family.
Family:
  • Belongs to the APC15 family.
genes like me logo Genes that share domains with ANAPC15: view

No data available for Suggested Antigen Peptide Sequences for ANAPC15 Gene

Function for ANAPC15 Gene

Molecular function for ANAPC15 Gene

UniProtKB/Swiss-Prot Function:
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. In the complex, plays a role in the release of the mitotic checkpoint complex (MCC) from the APC/C: not required for APC/C activity itself, but promotes the turnover of CDC20 and MCC on the APC/C, thereby participating in the responsiveness of the spindle assembly checkpoint. Also required for degradation of CDC20.
genes like me logo Genes that share phenotypes with ANAPC15: view

Animal Model Products

  • Taconic Biosciences Mouse Models for ANAPC15

CRISPR Products

miRNA for ANAPC15 Gene

miRTarBase miRNAs that target ANAPC15

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ANAPC15 Gene

Localization for ANAPC15 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ANAPC15 Gene COMPARTMENTS Subcellular localization image for ANAPC15 gene
Compartment Confidence
cytosol 5
nucleus 5
extracellular 1

Gene Ontology (GO) - Cellular Components for ANAPC15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with ANAPC15: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ANAPC15 Gene

Pathways & Interactions for ANAPC15 Gene

SuperPathways for ANAPC15 Gene

Superpath Contained pathways
1 CDK-mediated phosphorylation and removal of Cdc6
2 APC-Cdc20 mediated degradation of Nek2A
3 Cellular Senescence
4 Cell Cycle, Mitotic
.61
5 Mitotic Metaphase and Anaphase
genes like me logo Genes that share pathways with ANAPC15: view

Pathways by source for ANAPC15 Gene

Interacting Proteins for ANAPC15 Gene

Gene Ontology (GO) - Biological Process for ANAPC15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007067 mitotic nuclear division IEA --
GO:0031145 anaphase-promoting complex-dependent catabolic process TAS --
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process TAS --
GO:0051436 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle TAS --
GO:0051439 regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle TAS --
genes like me logo Genes that share ontologies with ANAPC15: view

No data available for SIGNOR curated interactions for ANAPC15 Gene

Drugs & Compounds for ANAPC15 Gene

(1) Drugs for ANAPC15 Gene - From: ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
TAME Pharma 0
genes like me logo Genes that share compounds with ANAPC15: view

Transcripts for ANAPC15 Gene

Unigene Clusters for ANAPC15 Gene

Anaphase promoting complex subunit 15:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ANAPC15 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d · 7e ^ 8 ^ 9
SP1: - - -
SP2: -
SP3: - -
SP4: - -
SP5: - - - - -
SP6:

Relevant External Links for ANAPC15 Gene

GeneLoc Exon Structure for
ANAPC15
ECgene alternative splicing isoforms for
ANAPC15

Expression for ANAPC15 Gene

mRNA expression in normal human tissues for ANAPC15 Gene

Protein differential expression in normal tissues from HIPED for ANAPC15 Gene

This gene is overexpressed in Pancreas (46.0) and Fetal ovary (19.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ANAPC15 Gene



SOURCE GeneReport for Unigene cluster for ANAPC15 Gene Hs.38044

genes like me logo Genes that share expression patterns with ANAPC15: view

Protein tissue co-expression partners for ANAPC15 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ANAPC15 Gene

Orthologs for ANAPC15 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ANAPC15 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ANAPC15 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ANAPC15 36
  • 90 (a)
OneToOne
ANAPC15 35
  • 93.87 (n)
  • 97.6 (a)
mouse
(Mus musculus)
Mammalia Anapc15 36
  • 92 (a)
OneToMany
Anapc15-ps 36
  • 82 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia ANAPC15 36
  • 56 (a)
OneToOne
chicken
(Gallus gallus)
Aves ANAPC15 36
  • 94 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ANAPC15 36
  • 74 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.6427 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.6387 35
zebrafish
(Danio rerio)
Actinopterygii anapc15 36
  • 83 (a)
OneToOne
Dr.13292 35
Species with no ortholog for ANAPC15:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ANAPC15 Gene

ENSEMBL:
Gene Tree for ANAPC15 (if available)
TreeFam:
Gene Tree for ANAPC15 (if available)

Paralogs for ANAPC15 Gene

Pseudogenes.org Pseudogenes for ANAPC15 Gene

genes like me logo Genes that share paralogs with ANAPC15: view

No data available for Paralogs for ANAPC15 Gene

Variants for ANAPC15 Gene

Sequence variations from dbSNP and Humsavar for ANAPC15 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs588693 -- 72,113,222(-) TATTC(A/C)TAGAT upstream-variant-2KB
rs2276396 -- 72,112,859(+) GCCCC(C/G)CCTTG upstream-variant-2KB
rs3793938 -- 72,112,087(-) CTGCT(C/T)ATCCC intron-variant, utr-variant-5-prime
rs7102392 -- 72,113,762(+) AGGTC(A/G)TGTAC upstream-variant-2KB
rs57170589 -- 72,114,624(+) TTTTT(-/T)GACAG upstream-variant-2KB

Variation tolerance for ANAPC15 Gene

Residual Variation Intolerance Score: 42.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.19; 4.30% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ANAPC15 Gene

HapMap Linkage Disequilibrium report
ANAPC15

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ANAPC15 Gene

Disorders for ANAPC15 Gene

Relevant External Links for ANAPC15

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ANAPC15

No disorders were found for ANAPC15 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANAPC15 Gene

Publications for ANAPC15 Gene

  1. APC15 drives the turnover of MCC-CDC20 to make the spindle assembly checkpoint responsive to kinetochore attachment. (PMID: 21926987) Mansfeld J. … Pines J. (Nat. Cell Biol. 2011) 2 3 4 67
  2. Structure of an APC3-APC16 complex: insights into assembly of the anaphase-promoting complex/cyclosome. (PMID: 25490258) Yamaguchi M. … Schulman B.A. (J. Mol. Biol. 2015) 3
  3. Atomic structure of the APC/C and its mechanism of protein ubiquitination. (PMID: 26083744) Chang L. … Barford D. (Nature 2015) 3
  4. Molecular architecture and mechanism of the anaphase-promoting complex. (PMID: 25043029) Chang L. … Barford D. (Nature 2014) 3
  5. Recombinant expression, reconstitution and structure of human anaphase-promoting complex (APC/C). (PMID: 23078409) Zhang Z. … Barford D. (Biochem. J. 2013) 3

Products for ANAPC15 Gene

Sources for ANAPC15 Gene

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