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ANAPC15 Gene(Protein Coding)

Anaphase Promoting Complex Subunit 15

GCID:
GC11M072106
GIFtS:
45
Genes Participants
UDN Logo

Aliases for ANAPC15 Gene

Aliases for ANAPC15 Gene

  • Anaphase Promoting Complex Subunit 15 2 3 5
  • C11orf51 3 4
  • APC15 3 4
  • Chromosome 11 Open Reading Frame 51 2
  • HSPC020 3

External Ids for ANAPC15 Gene

Previous HGNC Symbols for ANAPC15 Gene

  • C11orf51

Previous GeneCards Identifiers for ANAPC15 Gene

  • GC11M071817

Summaries for ANAPC15 Gene

GeneCards Summary for ANAPC15 Gene

ANAPC15 (Anaphase Promoting Complex Subunit 15) is a Protein Coding gene. Among its related pathways are Mitotic Metaphase and Anaphase and Cell Cycle Checkpoints.

UniProtKB/Swiss-Prot for ANAPC15 Gene

  • Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. In the complex, plays a role in the release of the mitotic checkpoint complex (MCC) from the APC/C: not required for APC/C activity itself, but promotes the turnover of CDC20 and MCC on the APC/C, thereby participating in the responsiveness of the spindle assembly checkpoint. Also required for degradation of CDC20.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANAPC15 Gene

Genomics for ANAPC15 Gene

Products:

  1. Regulatory Element

Regulatory Elements for ANAPC15 Gene

Enhancers for ANAPC15 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ANAPC15 on UCSC Golden Path with GeneCards custom track

Promoters for ANAPC15 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ANAPC15 on UCSC Golden Path with GeneCards custom track

Genomic Location for ANAPC15 Gene

Chromosome:
11
Start:
72,106,378 bp from pter
End:
72,112,780 bp from pter
Size:
6,403 bases
Orientation:
Minus strand

Genomic View for ANAPC15 Gene

Genes around ANAPC15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANAPC15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANAPC15 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for ANAPC15 Gene

Proteins for ANAPC15 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for ANAPC15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P60006-APC15_HUMAN
    Recommended name:
    Anaphase-promoting complex subunit 15
    Protein Accession:
    P60006
    Secondary Accessions:
    • G3V1Q3
    • Q9CXK2
    • Q9Y269

    Protein attributes for ANAPC15 Gene

    Size:
    121 amino acids
    Molecular mass:
    14281 Da
    Quaternary structure:
    • The mammalian APC/C is composed of 14 distinct subunits that assemble into a complex of at least 19 chains with a combined molecular mass of around 1.2 MDa.
    SequenceCaution:
    • Sequence=EAW74842.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ANAPC15 Gene

    Alternative splice isoforms for ANAPC15 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ANAPC15 Gene

Proteomics data for ANAPC15 Gene at MOPED

Protein Expression for ANAPC15 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for ANAPC15 Gene

No Post-translational modifications

Other Protein References for ANAPC15 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ANAPC15 Gene

Domains & Families for ANAPC15 Gene

Gene Families for ANAPC15 Gene

HGNC:

Protein Domains for ANAPC15 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

P60006

UniProtKB/Swiss-Prot:

APC15_HUMAN :
  • Belongs to the APC15 family.
Family:
  • Belongs to the APC15 family.
genes like me logo Genes that share domains with ANAPC15: view

No data available for Suggested Antigen Peptide Sequences for ANAPC15 Gene

Function for ANAPC15 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for ANAPC15 Gene

UniProtKB/Swiss-Prot Function:
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. In the complex, plays a role in the release of the mitotic checkpoint complex (MCC) from the APC/C: not required for APC/C activity itself, but promotes the turnover of CDC20 and MCC on the APC/C, thereby participating in the responsiveness of the spindle assembly checkpoint. Also required for degradation of CDC20.

Phenotypes for ANAPC15 Gene

GenomeRNAi human phenotypes for ANAPC15:
genes like me logo Genes that share phenotypes with ANAPC15: view

Animal Model Products

CRISPR Products

miRNA for ANAPC15 Gene

miRTarBase miRNAs that target ANAPC15

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ANAPC15 Gene

Localization for ANAPC15 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ANAPC15 Gene COMPARTMENTS Subcellular localization image for ANAPC15 gene
Compartment Confidence
cytosol 5
nucleus 5
extracellular 1

Gene Ontology (GO) - Cellular Components for ANAPC15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with ANAPC15: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ANAPC15 Gene

Pathways & Interactions for ANAPC15 Gene

SuperPathways for ANAPC15 Gene

PathCards logoMore details on SuperPathways for ANAPC15
Superpath Contained pathways
1 CDK-mediated phosphorylation and removal of Cdc6
Activation of APC/C and APC/C-Cdc20 mediated degradation of mitotic proteins
.95
Cdc20-Phospho-APC/C mediated degradation of Cyclin A
.95
APC/C-Cdc20 mediated degradation of Securin
.93
APC/C-Cdh1 mediated degradation of Cdc20 and other APC/C-Cdh1 targeted proteins in late mitosis/early G1
.93
APC/C-mediated degradation of cell cycle proteins
.93
Regulation of APC/C activators between G1/S and early anaphase
.93
Regulation of mitotic cell cycle
.93
Autodegradation of Cdh1 by Cdh1-APC/C
.91
APC/C-Cdc20 mediated degradation of mitotic proteins
.89
APC-Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
.89
Conversion from APC/C-Cdc20 to APC/C-Cdh1 in late anaphase
1
Phosphorylation of the APC/C
1
2 APC-Cdc20 mediated degradation of Nek2A
APC-Cdc20 mediated degradation of Nek2A
.80
Inactivation of APC/C via direct inhibition of the APC/C complex
.80
APC/C-Cdc20 mediated degradation of Cyclin B
.78
Mitotic Spindle Checkpoint
.77
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
1
3 Cell Cycle, Mitotic
Cell Cycle
.83
Cell Cycle, Mitotic
.83
M Phase
.61
4 Cellular Senescence
Cellular Senescence
.63
Senescence-Associated Secretory Phenotype (SASP)
.57
Cellular responses to stress
.49
5 Mitotic Metaphase and Anaphase
Mitotic Anaphase
.94
Separation of Sister Chromatids
.94
Mitotic Metaphase and Anaphase
.93
genes like me logo Genes that share pathways with ANAPC15: view

Interacting Proteins for ANAPC15 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000227618%0d%0a9606.ENSP00000318775%0d%0a9606.ENSP00000349957%0d%0a9606.ENSP00000343412%0d%0a9606.ENSP00000346987%0d%0a9606.ENSP00000264552%0d%0a
Selected Interacting proteins: ENSP00000227618 for ANAPC15 Gene via STRING

Gene Ontology (GO) - Biological Process for ANAPC15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007067 mitotic nuclear division IEA --
GO:0031145 anaphase-promoting complex-dependent catabolic process TAS --
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process TAS --
GO:0051436 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle TAS --
GO:0051439 regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle TAS --
genes like me logo Genes that share ontologies with ANAPC15: view

No data available for SIGNOR curated interactions for ANAPC15 Gene

Drugs & Compounds for ANAPC15 Gene

Products:

  1. Drug

(1) Drugs for ANAPC15 Gene - From: ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
TAME Pharma 0

(1) ApexBio Compounds for ANAPC15 Gene

Compound Action Cas Number
TAME 901-47-3
genes like me logo Genes that share compounds with ANAPC15: view

Transcripts for ANAPC15 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for ANAPC15 Gene

(11) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(593) Selected AceView cDNA sequences:
(17) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ANAPC15 Gene

Anaphase promoting complex subunit 15:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ANAPC15 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d · 7e ^ 8 ^ 9
SP1: - - -
SP2: -
SP3: - -
SP4: - -
SP5: - - - - -
SP6:

Relevant External Links for ANAPC15 Gene

GeneLoc Exon Structure for
ANAPC15
ECgene alternative splicing isoforms for
ANAPC15

Expression for ANAPC15 Gene

Products:

  1. Primer

mRNA expression in normal human tissues for ANAPC15 Gene

mRNA expression in normal human tissues for ANAPC15 Gene
mRNA expression by BioGPS for ANAPC15 GenemRNA expression by GTEx for ANAPC15 Gene

Protein differential expression in normal tissues from HIPED for ANAPC15 Gene

This gene is overexpressed in Pancreas (46.0) and Fetal ovary (19.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ANAPC15 Gene



SOURCE GeneReport for Unigene cluster for ANAPC15 Gene Hs.38044

genes like me logo Genes that share expression patterns with ANAPC15: view

Protein tissue co-expression partners for ANAPC15 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ANAPC15 Gene

Orthologs for ANAPC15 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ANAPC15 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
 Mammalia ANAPC15 35
  • 93.87 (n)
  • 97.6 (a)
ANAPC15 36
  • 90 (a)
 OneToOne
cow
(Bos Taurus)
 Mammalia ANAPC15 36
  • 98 (a)
 OneToOne
oppossum
(Monodelphis domestica)
 Mammalia ANAPC15 36
  • 56 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Anapc15 36
  • 92 (a)
 OneToMany
Anapc15-ps 36
  • 82 (a)
 OneToMany
chicken
(Gallus gallus)
 Aves ANAPC15 36
  • 94 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia ANAPC15 36
  • 74 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia Str.6387 35
African clawed frog
(Xenopus laevis)
 Amphibia Xl.6427 35
zebrafish
(Danio rerio)
 Actinopterygii Dr.13292 35
anapc15 36
  • 83 (a)
 OneToOne
Species with no ortholog for ANAPC15:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ANAPC15 Gene

ENSEMBL:
Gene Tree for ANAPC15 (if available)
TreeFam:
Gene Tree for ANAPC15 (if available)

Paralogs for ANAPC15 Gene

Pseudogenes.org Pseudogenes for ANAPC15 Gene

genes like me logo Genes that share paralogs with ANAPC15: view

No data available for Paralogs for ANAPC15 Gene

Variants for ANAPC15 Gene

Sequence variations from dbSNP and Humsavar for ANAPC15 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs588693 -- 72,113,222(-) TATTC(A/C)TAGAT upstream-variant-2KB
rs602285 -- 72,112,482(-) CACCC(C/G)GTCAC intron-variant, upstream-variant-2KB
rs2276395 -- 72,113,296(-) GAGAC(C/T)ACTAA upstream-variant-2KB
rs2276396 -- 72,112,859(+) GCCCC(C/G)CCTTG upstream-variant-2KB
rs61889218 -- 72,112,770(+) TTCCC(C/G)GCTCC upstream-variant-2KB, utr-variant-5-prime

Variation tolerance for ANAPC15 Gene

Residual Variation Intolerance Score: 42.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.19; 4.30% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for ANAPC15 Gene

Disorders for ANAPC15 Gene

Relevant External Links for ANAPC15

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ANAPC15

No disorders were found for ANAPC15 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANAPC15 Gene

Publications for ANAPC15 Gene

  1. APC15 drives the turnover of MCC-CDC20 to make the spindle assembly checkpoint responsive to kinetochore attachment. (PMID: 21926987) Mansfeld J. … Pines J. (Nat. Cell Biol. 2011) 2 3 4 67
  2. Structure of an APC3-APC16 complex: insights into assembly of the anaphase-promoting complex/cyclosome. (PMID: 25490258) Yamaguchi M. … Schulman B.A. (J. Mol. Biol. 2015) 3
  3. Atomic structure of the APC/C and its mechanism of protein ubiquitination. (PMID: 26083744) Chang L. … Barford D. (Nature 2015) 3
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  5. Molecular architecture and mechanism of the anaphase-promoting complex. (PMID: 25043029) Chang L. … Barford D. (Nature 2014) 3

Products for ANAPC15 Gene

Sources for ANAPC15 Gene

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