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ANAPC15 Gene

protein-coding GIFtS: 37
GCID: GC11M071817

Anaphase Promoting Complex Subunit 15

(Previous name: chromosome 11 open reading frame 51)
(Previous symbol: C11orf51)

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Aliases
Anaphase Promoting Complex Subunit 15¹ ²
C11orf51¹ ² ³
APC15² ³ ⁵
Chromosome 11 Open Reading Frame 51¹
Anaphase-Promoting Complex Subunit 15²

External Ids:	HGNC: 24531¹	Entrez Gene: 25906²	Ensembl: ENSG00000110200⁷	OMIM: 614717⁵	UniProtKB: P60006³

Export aliases for ANAPC15 gene to outside databases

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ANAPC15 Gene:

ANAPC15 (anaphase promoting complex subunit 15) is a protein-coding gene.

UniProtKB/Swiss-Prot: APC15_HUMAN, P60006

Function: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin

ligase that controls progression through mitosis and the G1 phase of the cell cycle. In the complex, plays a role

in the release of the mitotic checkpoint complex (MCC) from the APC/C: not required for APC/C activity itself,

but promotes the turnover of CDC20 and MCC on the APC/C, thereby participating in the responsiveness of the

spindle assembly checkpoint. Also required for degradation of CDC20

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000011.9 NT_167190.2 NC_018922.2

Regulatory elements:

Search for regulatory transcription factor binding sites for ANAPC15
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search Chromatin IP Primers for ANAPC15

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ANAPC15

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13.4 Ensembl cytogenetic band: 11q13.4 HGNC cytogenetic band: 11q13.4

ANAPC15 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ANAPC15 gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11M071817: view genomic region (about GC identifiers)

Start:	71,817,424 bp from pter	End:	71,823,826 bp from pter
Size:	6,403 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: APC15_HUMAN, P60006 (See protein sequence)

Recommended Name: Anaphase-promoting complex subunit 15

Size: 121 amino acids; 14281 Da

Subunit: The APC/C is composed of at least 12 subunits

Sequence caution: Sequence=EAW74842.1; Type=Erroneous gene model prediction;

Secondary accessions: G3V1Q3 Q9CXK2 Q9Y269

Explore the universe of human proteins at neXtProt for ANAPC15: NX_P60006

Explore proteomics data for ANAPC15 at MOPED

See ANAPC15 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (11 alternative transcripts):

NP_001265414.1 NP_001265415.1 NP_001265416.1 NP_001265417.1 NP_001265418.1 NP_001265419.1 NP_001265420.1 NP_001265421.1

NP_001265422.1 NP_001265423.1 NP_054761.1

ENSEMBL proteins:

ENSP00000441774 ENSP00000437360 ENSP00000445212 ENSP00000439403 ENSP00000443645

ENSP00000227618 ENSP00000443911 ENSP00000446412 ENSP00000446383 ENSP00000440002

ENSP00000443383 ENSP00000440983 ENSP00000437683 ENSP00000389730 ENSP00000439362

ENSP00000440380

ANAPC15 Human Recombinant Protein Products:

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	antibodies-online proteins for ANAPC15
	antibodies-online peptides for ANAPC15

ANAPC15 Antibody Products:

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	antibodies-online antibodies for ANAPC15 (3 products)

ANAPC15 Assay Products:

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	Search antibodies-online for kits for ANAPC15

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:

ANAPC: Anaphase promoting complex subunits

1 InterPro protein domain:

IPR026182 ANAPC15

Graphical View of Domain Structure for InterPro Entry P60006

ProtoNet protein and cluster: P60006

UniProtKB/Swiss-Prot: APC15_HUMAN, P60006

Similarity: Belongs to the APC15 family

Find genes that share domains with ANAPC15 About GenesLikeMe

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

UniProtKB/Swiss-Prot Summary: APC15_HUMAN, P60006

Function: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin

ligase that controls progression through mitosis and the G1 phase of the cell cycle. In the complex, plays a role

in the release of the mitotic checkpoint complex (MCC) from the APC/C: not required for APC/C activity itself,

but promotes the turnover of CDC20 and MCC on the APC/C, thereby participating in the responsiveness of the

spindle assembly checkpoint. Also required for degradation of CDC20

Phenotypes:
3 GenomeRNAi human phenotypes for ANAPC15:

Cell division defect

Increased G2M DNA content

Increased number of mitotic ce

Animal Models:

genOway: Develop your customized and physiologically relevant rodent model for ANAPC15

miRNA Products:		miRTarBase miRNAs that target ANAPC15: hsa-mir-192-5p (MIRT026242), hsa-mir-215-5p (MIRT024289)

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Gene Editing
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANAPC15

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Gene Ontology (GO): 2 cellular component terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	IDA	--
GO:0005680	anaphase-promoting complex	IDA	--

Find genes that share ontologies with ANAPC15 About GenesLikeMe

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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Custom Pathway & Disease-focused RT² Profiler PCR Arrays for ANAPC15
Interactions:

Search GeneGlobe Interaction Network for ANAPC15

STRING Interaction Network Preview (showing 5 interactants - click image to see 22)

Selected Interacting proteins for ANAPC15 (ENSP00000227618⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 22)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ANAPC16	ENSP00000299381⁴	STRING: ENSP00000299381
CDC16	ENSP00000348554⁴	STRING: ENSP00000348554
CDC23	ENSP00000378350⁴	STRING: ENSP00000378350
ANAPC1	ENSP00000339109⁴	STRING: ENSP00000339109
ANAPC10	ENSP00000310071⁴	STRING: ENSP00000310071

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Gene Ontology (GO): 2 biological process terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007067	mitosis	IEA	--
GO:0090266	regulation of mitotic cell cycle spindle assembly checkpoint	IMP	--

Find genes that share ontologies with ANAPC15 About GenesLikeMe

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for ANAPC15 (APC15)

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for ANAPC15 gene (11 alternative transcripts):

NM_001278485.1 NM_001278486.1 NM_001278487.1 NM_001278488.1 NM_001278489.1 NM_001278490.1 NM_001278491.1 NM_001278492.1

NM_001278493.1 NM_001278494.1 NM_014042.2

Unigene Cluster for ANAPC15:

Anaphase promoting complex subunit 15

Hs.38044 [show with all ESTs]

Unigene Representative Sequence: AK311146

17 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000502597(uc009ytc.1) ENST00000543050 ENST00000538117 ENST00000543587(uc001orv.3)

ENST00000543015 ENST00000545680 ENST00000227618(uc001orw.3) ENST00000542531

ENST00000535234 ENST00000545944 ENST00000538393 ENST00000535503 ENST00000538919

ENST00000537644 ENST00000438939 ENST00000545333 ENST00000539395

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Additional mRNA sequence:

AF077206.1 AK222622.1 AK311146.1 AL080071.1 BC005156.2 BC005393.1

12 DOTS entries:

DT.91640431 DT.102824953 DT.120712088 DT.85105330 DT.120711959 DT.97843177 DT.120711949 DT.85105329

DT.95233089 DT.120712098 DT.121281162 DT.92473190

Selected AceView cDNA sequences (see all 593):

AI095684 AI149055 AI151518 CB853459 AI220889 BM740885 CK823821 Z24996

BU951805 AI375781 AW299903 BX361114 BQ689970 AA953741 BQ420503 BM717442

BU622870 BX108870 BM847310 BQ073364 CA394650 AI620143 AA654232 BM976521

GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for ANAPC15 (see all 6) About this scheme

ExUns:	1a	·	1b	^	2	^	3a	·	3b	^	4	^	5	^	6	^	7a	·	7b	·	7c	·	7d	·	7e	^	8	^	9
SP1:					-				-								-
SP2:					-
SP3:					-												-
SP4:					-												-
SP5:																	-		-		-		-		-

ECgene alternative splicing isoforms for ANAPC15

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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ANAPC15 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: --

About this image

ANAPC15 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

ANAPC15 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.38044

Custom PCR Arrays for ANAPC15

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ANAPC15

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for ANAPC15 gene from Selected species (see all 9) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Anapc15⁵	RIKEN cDNA 3200002M19 gene	--		7 (54.68 cM) 101881325
chicken (Gallus gallus)	Aves	ANAPC15⁶	anaphase promoting complex subunit 15	94(a)	1 ↔ 1	AADN03013815.1(21-2356)
lizard (Anolis carolinensis)	Reptilia	ANAPC15⁶	anaphase promoting complex subunit 15	74(a)	1 ↔ 1	GL343792.1(7520-21283)
African clawed frog (Xenopus laevis)	Amphibia	Xl.6427²	Xenopus laevis transcribed sequence with moderate similarity more	80.17(n)		48058459
zebrafish (Danio rerio)	Actinopterygii	Dr.13292²	Transcribed sequence with moderate similarity to protein more	83.5(n)		BI672822.1

ENSEMBL Gene Tree for ANAPC15 (if available)
TreeFam Gene Tree for ANAPC15 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for ANAPC15 gene

Find genes that share paralogs with ANAPC15 About GenesLikeMe

1 Pseudogenes.org Pseudogene for ANAPC15
PGOHUM00000241182

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs3750908^1,2	C,F,H	--	71822401(-)	`ATCCCT/CAAATC`	1	--	int¹		21		NS EA NA WA CSA	2347
rs146865224^1,2	C	--	71822475(+)	`CCTGG-/CTCCAC`	1	--	ut5¹		0	--	--	--	--
rs3750907^1,2	C,A	--	71822560(-)	`TTGTTA/GTTATC`	1	--	int¹		4		CSA WA NA EA	361
rs5024241^1,2	H	--	71822682(+)	`TCCAGA/GATGCA`	1	--	int¹		4		NS EA	408
rs188151392^1,2		--	71822809(+)	`CCCACA/CCAGTG`	1	--	int¹		0	--	--	--	--
rs56249089^1,2	C,F	--	71822845(+)	`TCTCAT/CGAATC`	1	--	int¹		3		WA CSA	122
rs117818925^1,2	C,F	--	71822952(+)	`GAAGAT/CTGAAT`	1	--	int¹		1		NA	120
rs180802445^1,2		--	71822953(+)	`AAGATG/TGAATG`	1	--	int¹		0	--	--	--	--
rs184273048^1,2		--	71822960(+)	`AATGGA/GTGAAC`	1	--	int¹		0	--	--	--	--
rs188657504^1,2		--	71822989(+)	`ATCAGC/TTTTGA`	1	--	int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for ANAPC15 (71817424 - 71823826 bp)

Structural Variations
Database of Genomic Variants (DGV) variations for ANAPC15: --

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing ANAPC15

DNA2.0 Custom Variant and Variant Library Synthesis for ANAPC15

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 614717 OMIM disorders: --

Find genes that share disorders with ANAPC15 About GenesLikeMe

Export disorders for ANAPC15 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for ANAPC15 gene, integrated from 10 sources (see all 13):
(articles sorted by number of sources associating them with ANAPC15)

Utopia: connect your pdf to the dynamic
world of online information

APC15 drives the turnover of MCC-CDC20 to make the spindle assembly checkpoint responsive to kinetochore attachment. (PubMed id 21926987)^{1, 2, 3} Mansfeld J.... Pines J. (Nat. Cell Biol. 2011)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)^{1, 2} Wiemann S.... Poustka A. (Genome Res. 2001)
Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)^{1, 2} Zhang Q.-H.... Chen Z. (Genome Res. 2000)
Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)¹ Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
Transcriptional intermediary factor 1I^ binds to the anaphase-promoting complex/cyclosome and promotes mitosis. (PubMed id 23160376)¹ Sedgwick G.G....Turnell A.S. (Oncogene 2013)
APC15 mediates CDC20 autoubiquitylation by APC/C(MCC) and disassembly of the mitotic checkpoint complex. (PubMed id 23007861)¹ Uzunova K....Peters J.M. (amp 2012)
hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)¹ Lamesch P.... Vidal M. (Genomics 2007)
Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)² Taylor T.D....Sakaki Y. (Nature 2006)
Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PubMed id 15146197)¹ Brandenberger R.... Stanton L.W. (Nat. Biotechnol. 2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 25906	HGNC: 24531	AceView: DKFZP564M082andFLJ20625	Ensembl:ENSG00000110200	euGenes: HUgn25906
ECgene: ANAPC15	H-InvDB: ANAPC15

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for ANAPC15	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ANAPC15 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for ANAPC15 gene:
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(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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ANAPC15 Gene

Anaphase Promoting Complex Subunit 15

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ANAPC15 Gene

Anaphase Promoting Complex Subunit 15

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